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<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HJ60</accession>
    <name>A0A922HJ60_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DERF_014710</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HJ60"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004465">
        <property type="term" value="F:lipoprotein lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="17">
        <location>
            <begin position="410"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="586"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="710"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="881"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="881"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="902"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9493986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="913" mass="106026" checksum="77A8D34E6C315D76" modified="2023-02-22" version="1">MPGLVIVSRRWNIGSDDIIVPASIYLITHLLWILIYLFICAKNGTLFLDDNCPLIITLPVFGQFISLFGFVILEIFMIKYCFIIEILWEIYGLLIMMHNKFDSYNDQCASTKGIVIGLKIFLLLIWTSFILFVWCAFDYAGKSWVKMKRFQESLNNPNSKYKYRRSNSFHRNWRHREALRKYQQSWLNRCRWFCCVKDRRDNSFTEIAKLLSEFFRDLDVVPSDVVAGLSLMRVQQKSQRKERMMNDNEEPKIFQFLSGAAITAETKFLDLTHVLVIREVYNLIHYLHYSLAIYGWPMYMVANQPSQWFHLLKHIKCCGNQSSRWAKCSRCCSGGHIDTDTIIDSDDQQFVNIYRESDNILGDNCCLCNRAAIRQTCIDHDYKIIYITYYVAIEKPPFFVAVDYDKMSIVISIRGTLSLYDVLTDLNAEYDLLPLTPPRENWYGHKGMVAAAAYIRSRLIEKHIIEIANEELKIRNLATNSHHQYPIIIVGHSLGADLAEYSKDFVISIVLGKDIIPRLGLHQMEKLRFDLIKAIKHCDMSKWPIIFKSFRIGSSDINHDEYVKKFKIKSDNIIISQTVTDSFVECKHNNNGNSQNISPSSSQTHHHHQQHQHHHHHLSSKEPIENISTHPNDENIQLTVHTPLYPPGSIIHLVKAHPNKSERIIGQKQFIIQALWAGYEDFDEILISPSMIRDHMPDRILEALESLLINTGPPKPKRKTEDSYDDDGVDNDDNNNNNHNNSIDDSIDNDSKYYSSIQDTNDHIYQQSHHHHHHHHSKRIMLETSFASAIPATSMTTTASEQLAAIRKNRRKKFDNHNNNDEVYNEERLRRLRSFIAKRKAPLATPETVSLTDDVCEQQQQQQQRQRQQKPVVIVSTISNNQFDTQIQTPSSSSSSNQYEQINDRKTSLPEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKU1</accession>
    <name>A0A922HKU1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_015941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKU1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21998">
        <property type="entry name" value="HMG-box_UBF1_rpt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21999">
        <property type="entry name" value="HMG-box_UBF1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22003">
        <property type="entry name" value="HMG-box_UBF1_rpt6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051762">
        <property type="entry name" value="UBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318">
        <property type="entry name" value="UPSTREAM BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318:SF3">
        <property type="entry name" value="UPSTREAM BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="186"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="273"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="372"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="186"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="273"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="372"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="694"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="721"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9491210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="796" mass="93178" checksum="5CE13E999AB25909" modified="2023-02-22" version="1">MEQQQKTIKEEILDSDANKSSDSSMNTKKKRKKSKLNSDETDDNSMTTLANYKSDNNDDNDEMSMMMMIMNDGVNNGVVETELLELSNDTVITDNFDNRWSTNDLKTLLENIKKCLPQNDLTKYSTTLEKTINWDQVKFKHFDANECKECAVNIINGLRKYRTLTEMLGDAFEWTNKRHLNHPNRPKKPCSLFLRYFLEKRPKLQQQYPNKSVAELAKILSTKFAKLSDKKRAKYRRDYEEDLIKYREQMIQFRTKYPELFSQRMRTGEKIGPEKPRTPFQLYRLSKMKKIPTDTDEDPKAIQDRIREQWNNISEKKHYKFIKKSLKDQERYNQELEEFMAANPTYTAPVIMKPLLTKNEQELRRRYQGMPMRPPNSGYMLFSQIMLKEFKDVPSKEKMVLVAKRWKEMTIEERSKYNEDAQNMMSEYIRKFDEYVHTLPDDEKKQLLIEQGHFKLPSEKNIFSSNKQFMPTSSIVSLAKEMQKKTAAIDQTAMIAYQMNEMQRLKPIYSDKTNAELMDMINEQWSSMPAIQKTEYLEVAESMQDFLPSNTKTKKSSTTTTTATRRKESSKDIKFKDVKESEFFLQTGLRKPRRCGFTTYCSSILSTMINKTTQERMRYASEQWKQMSVEQKQYYLQLQSSKCEMFEKLFNRFKKDGTLPSKKEMKEFNKAGTITATTDEMLELSEIKNEKEMKKVKKRKLDNNNDDDDSRKTIEWNENQTLSSTSSSSSPSLTLSSTLKSLKKASALSSSSSSTTTTTITPIESFSSTTKSKKKFSNCLYDDSSSSSENDDDVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLG3</accession>
    <name>A0A922HLG3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLG3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="116" mass="13575" checksum="BDA56E7F835076BD" modified="2023-02-22" version="1" fragment="single">NLLINQMILTDISLSYCMYRIVVGFFIFSFRVPSSSSSSSLRKWWAGWLCLGSVFCLFTRHEDFFFVPDARHLVSCDEKNFEFSLKKSNSFCPTDGTKCNNHEMNQNDYFNQSDHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMA6</accession>
    <name>A0A922HMA6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Strictosidine synthase conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_013465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the strictosidine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMA6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="5">
        <location>
            <begin position="204"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9497472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="525" mass="59959" checksum="0FBD455C782AC724" modified="2023-02-22" version="1">MDQLKNLLNLIMKYLSILLIVISSLFTTKNFVQCFRPYNYYAPHQYPETGPLSYNFPLIKAFRGELTPNNMLSQATHLCEGALMGPSSLVVYQHYLYTGTIGGGIYRCNLETGNATRIVKVANELCRTKYWDASLCGRPLGIRVDRSGNLYFIDAYLGLHQISFYGANQQRLRVKRLLSPDQVGSRYMTHLALDEGGGTNGGIVFYITIASTRHDLNEWPRMILEPDRSGRVVRFDMDLNQTEVLMQGLWYPSSVQLSDDRTSILVVEFTARRVVRHYIRGPQRGKTETWIQNLPGEGEHLIRSLDKYQETYWLPVVNARNVSSPSMIDWLSDKPWIREEIMQNFTALGQKIEMLGSKWSNSNLERLGFRLKNLHFFYDEAISNDYGMVLELDSNGRLLGSLHSIDGSNFRLSEVVEGPTENPYERVLYIGSYTNPYILKLTIPNFTQDYQQKNKQITSNNKVTENGVDFSLLPYGSTRRAIATNLDGTNTISLDDDNKAIFINPSTSTLNRRLRKDATRYSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMN7</accession>
    <name>A0A922HMN7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CD2 antigen cytoplasmic tail-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CD2BP2</name>
        <name evidence="3" type="ORF">DERF_013611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMN7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.40:FF:000005">
        <property type="entry name" value="CD2 antigen cytoplasmic tail-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="276"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="337" mass="39477" checksum="6357AED3A56FF0CE" modified="2023-02-22" version="1">MNENNQISDNGDENVDEKHNAFGKKFKHTLDSDEEDDEIGAEKYNVLDDDAIEGTERTTIEFDGDIKITPFNMDEELETGHFDKEGTYIFKKENDIRDNWLDNINWNVIKPTKTETIKKDEINADQDSSSDENEETTISQASIKEFYEQIILLVQPGESIRKAIQRYGKLCNPERKGQKRKIHSNEATTNQQSSDKNEAKEKMMKLISIADQILQTGDMDIYERTFEQFKLQLNKINDVESIRKQSSDNNDDMFSDDFDDKKQSTSKTVISMDETKTKWEYRWEDKDNAQIYGPYSSEDMLNWTNQGYFDQGVFVRRIESTDARFYSSKRIDFELYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN96</accession>
    <name>A0A922HN96_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN96"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="8129" checksum="258561DDDD8F87D0" modified="2023-02-22" version="1">MQIQERIIFFIWYKKIVFLYSLSFISIIFSFIIRYPDGDDDDDDGIFKCYRNRDKKNLCKSHHQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNK2</accession>
    <name>A0A922HNK2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_012966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9496945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNK2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="70"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="288"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9496945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="668" mass="75248" checksum="E8449E3DE5E2B042" modified="2023-02-22" version="1">MSTNFKRKFYHESQNETSIDDKKQIKNWSLPEKIIHYYGQMGINRFFDWQVECLELPGVLDDQKKSCIFCANQRKKAIIVLPFVSLSLEKVENLKPLFNQVGIRIDCFAGQTNPLGGIQEVDVAVCTIEKANNMINRLIEEREMYRIGLVIVDELHMIGDTSRGYILELMLSKLIYMKLNVDLRQLQIIGMSAIIPNLNDIAKWLDAELFVTDYRPVPLNEHVVDNKIIKISTNSIQSPYTQFDSLASTVVSSGGPSNNDNNGKIECIPIKTIDCNLLKLNTTFSKSLIYMAIETLVQGFSTLIFCPTRSIIHSDNILSYERIVSLINTLKRSSSGFDQNLERVLKFGCAFHHAGMTMEERGIVEQGFRDAPLKILCCTTTLSTGVNLPARRVMIISPYDYSSKLLPVGIYRQMIGRAGRKGIDTMGESYLFCTDKDINMARRLITTKMPSIKSNLITIQKLKNNKPSATTTTSVGQQIPTTSNKQWEPVVNDPILRAVLEVIANEMVKNIDDIHVYLGRTFFCNCPLNLLLASEEQQSSQTNMEELRMEKVEIINECIRMALDKLKTYEFISIDSSEEANNSSETKSVDSSSPINVTELGRAVISSGVSPSDGQFIYEELKCFRSNLSSPLPDLYMVYLLSKIVFELLILNSLQSLSVNDDPGTSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNM4</accession>
    <name>A0A922HNM4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_011925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNM4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03230">
        <property type="entry name" value="ABC_DR_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038:SF3">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 20 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="4"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="9">
        <location>
            <begin position="434"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9501057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="675" mass="76797" checksum="FA720D4A1824D669" modified="2023-02-22" version="1">MTAVQLSNVNFYYAKQRPILEDINLQVPYGKIYSLLGPSGAGKTTLLRLILGRIEANSGEIHVLGGLPGQNNRIVGYMPQDQALCRTFTVGQTLQYFANLYRLTGKEFRVRKQNLQKILGLPDDDKRISELSGGQQKIVSLSVTFLQRPKLMILDEPTVGSDPTLGDYIWKYLHLLCQQDNIVIIVVTHYIEEAVRAHIVGIMREGRMLEEDDPMALIERYEQRTLEDVFLYLCQNDPKPKIIDNDDNNNETDKIDEIIVKNGNHKTIDTINPEESTSNMYQTSNWSKIVLNLWILIVLVHKNLSRFFQLNITTLIFLIPAFQALILGLMYDVDEVAIPIGVCNNEPDPYYSVRLFDFIEKVDIYYLKPKYYDNEEQAMNALKYGHIVGILIFDSNFTDAMITRVNDPDSMTNETYLSSIIRIHMDNSNFLFANGFIDSLRQTVYNFLTMVHQEQNLTRFEAPIDLHDIIYAKDSKLSDFLLPGYLIAFIYLSQLTISAQLLVQERSEGLFERSLVAGVSHNLVLLSHFFSSFVASAIQVTLMLYVGLFLFEMINEGPIWLVFTMVMAQALSSVATGLLISSVVKEGSTATMFSIFITFSQVFTSGTIFPRELVPQNFQYLVDFSPIGIPSQSLRNVMLRSWPITHPNVYNGLALNIISTIILLIISGFLFKKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP40</accession>
    <name>A0A922HP40_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP40"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="581" mass="68159" checksum="C018E11B83CA25CD" modified="2023-02-22" version="1">MTIMMIISFVNGNVYWSCSWEKHQYWKSGGSSNSKSDDGDDNNIRLTFDKDLVSISSINNKRWYLFDSFAHVTIFDEMAGVHYYDDDGDDSLNQFNFRSTRYNGERKPFYSLAPTESSSDDGEFHVELNEKQLNQIKYTGGDSLLFPNDDDHHHRDRKKRNLKIWPPKLSVQTFINHEKIFHFHLRIYDYFIVIGQRTKYHHHHGGQKQQSDIVYEEPMNGESFIWISDQQQNHLYWIRKFESTVISSSSYDNFQLFHTRDKFPPNGGGQYLGSLCVQTNGSHQINRLITGECSGPLKTHRLLMALDFGFIHRGSLYLISNRKFFILKMDKSILTDRHQVHYQLLSWTSFFQCPLPPLYRHFSPLFFAIIIIEFLLFMMLFGCILLMIYKKFVRKNSHTRQKRKKFQYQSMLSPSTTVIMTKKQINNPWKMMNKRLPSPYCLCVRSILSMAIITNNDTTSIITIDNMIDSSLKTTIESSSSSSSPSSIYRKFTAIVLFTLFTLILTGYHILSRWLMSRSVVVVDKKRRRRRRCRRRHKTRRKRRSNHHPLSSSKSKRILLSSKTFKSSSSSIAVTTKIGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP54</accession>
    <name>A0A922HP54_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_012210</name>
        <name evidence="3" type="ORF">HUG17_8980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP54"/>
    <dbReference type="OrthoDB" id="10626851at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7637876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9501357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="302" mass="35227" checksum="50AC3E88B061A3CF" modified="2023-02-22" version="1">MNSNPSPSESSTTYYFILKPFIWTLTLLQFTYFFISSLILWIIRPLASRCQTFRLARELDKINEKMRKLRSDYEKATRQYHEQCQHIDQKRRELNEHKDRLVLQLAAIDQWSKQVKPKEPMTTIKTSTSDMKTISTYIKDYESIAKNVDTKSMAKWFDRQFSCGAQSNTVIKTSPLSSPLLRSPSRTSNAKKSEKILTKSLSLDPKSSASSSEIKLMKLKNQSKFVDSNGDGNQSEQSHPDKMQKSDDDKVLDQMVITTLNEFRSNETNSELNQTIRELYNDPEWKPMIDQLRNQYQLFSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPM3</accession>
    <name>A0A922HPM3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arginine n-methyltransferase 5-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Methylenetetrahydrofolate dehydrogenase [NAD(+)]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mtd1</name>
        <name evidence="5" type="ORF">DERF_014679</name>
        <name evidence="4" type="ORF">HUG17_6538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7644176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPM3"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004487">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000012">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="2">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="3">
        <location>
            <begin position="141"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7644176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9493955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="312" mass="35203" checksum="1B6DC141DD9C4D6D" modified="2023-02-22" version="1">MECQVITGARIAEKFLDELTRQIKDVDAQVKLVSFLANNDPSAEQYAEVTKKSCARSGIVFELRKIGREELEDAVIAANDDDTIHGILVYYPVFGGGHDQYIQNCVNPFKDVEGLCHLYRFNMYRNIRHIQGRKDLKSIIPCTPLAVIKVLEHCNVYDNDVPYGNQLRGKTITIINRSEVVGRPLAALLANDGAKVYSVDINDILLFYRGPDLELNKYKVQDTDKKLEEVLPISDIVITGVPSSNYRVPLDLLKDGVIAVNFACAKNFDDEIKTKASIFVPTIGKVTTTMLQRNLLRLYKYRTYGRYSNGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ43</accession>
    <name>A0A922HQ43_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ43"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="545" mass="63530" checksum="C9DD43C13EEB24C6" modified="2023-02-22" version="1">MKSRFCEEFEYQKQHHFHRTLPPEQMMNNIIFSVEVWPPFINLINLERNSSTVICGPLLGYLIELANRLKSNITYIPDLGNETLPFSDFKENGINVVLSPYTPMNLFNEHVQEHIHLSRIMSDVPMMSIISGTKKLKINWSVFNSFNDPFVHLYALYFIFIGIFILTFNRLIFGSMKLKIIYDMIRTLFGQPIPRLDYDKKIRFLLLNLIWLTFFLKLFLSYILLALNQFGHAYDRIDTLDDLVNHRNMKVFLFKGEPSQTILTAFDHPFYYDLENRFLIEDPPNEDIEDWENKIANEINDRKLAMISDEYYLDYFQYVFLNKFPNLYRSIRNDVVLPYFLPLSNKNSNEMDHSLNEMIISLSENGLYNYWVIETLNQNKVEIYTKMNHKHTINDFEVMSLSINDIQAIISIYCIFSIKSILILFIEILVKKISMMKNTMANSVSHLGSSDINLTESIGSSNIHVNRQRQSQGFSANRNTCATPGPALGKNGKVCRRFSDNKTSRSSGNFSKNSPFKLNAPPSINEMLHDDMINLDNCIGSFRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ66</accession>
    <name>A0A922HQ66_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PRP40 pre-mRNA processing factor 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PRPF40A</name>
        <name evidence="6" type="ORF">DERF_013771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ66"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000003">
        <property type="entry name" value="Pre-mRNA processing factor 40 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000002">
        <property type="entry name" value="pre-mRNA-processing factor 40 homolog A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="267"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="394"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="481"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="683"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="765"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
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        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="837"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="897"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="935"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9497815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="994" mass="113562" checksum="FD597B1AA98F5F83" modified="2023-02-22" version="1">MQNPSGFPTAPFPPIIMPSSSNTASMIPGAGVGQPIIPFQPPFNPFSAAAAAAAAAAAGIPIPPVTQLTPMPQTMLPTTTPMVTSSSSLSSNNNNWVEYKTPDGSPYYYNIITKQTSWTKPDELKSDIERLLDSCPWKEYKTEDGKIYYHNIVTKNSSWTMPKELEELKKQSNDNTTIQSASESINSQTSTLISTNDNNNNENNNDQTPTNDENIQNENVNSQLPSSSSYDTDSNDNSNSMPETPPPPPSSSKSDSLPDSLPKQPSKGDLLEMFKDILREKNISSNASWENTLKIVGNDSRFEKFRSHPERKQFFNAYKIQRAKEEKEEMKNKIRRAKEALASFLRRTDRMNSMIRYRHACELFRDHEHWKIVPETERREIFEDAVAELSRKERDEAKQLRKRNMSVLSEILDSMPKITFRTTWQEAQQLLLDNATFAEDSQLLNMDKEDALIVFERHIRQLESEEDEEKARAKRIQERQKRLNRESFIQFLDELHASGKLNSLSKWCTLYPDISSDVRFDSMLSQPLSGSTPLDLFKFYVDDLKARYEDEKIVIKDILQKATDFIMTPNTEFSEFVTILSKDTRSAKLDSGNVKLMHEKLLEKEREKYRAKKREENKQRKRMESIFLDMLSRISPSLDENSKWNDIRPLICNQEAFVSITDEQERITIFERAINSIVESCSHHHNHHKSGHRHQHQQQQQHRCRSSTNDDDGVSGGGGGSSERQIKRQNKEKEIIINTNKDKKKKLKKKSSSKHHHHHHRRQHQSSSSISESNESIDGGGGGGDDDDDVSISDHSRSPTTPITSSSSFNNDDDDENNSHYDRNSSGSNLQNNRNNNSRHHHQHSSQKRHLKSIDRHHRSQSPTSSPPPPPPSSSSSSKALNRYHHHSRSRSPIPINHHHRISSSSSYHRRSSSISPTRSRTKRVKHTSEYDIGSSTSSNSGRNRNNNNKRYDNDDDPNNHLIPLDSIGLNGSDDLEDLEKQRKLLLKQLENST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQC2</accession>
    <name>A0A922HQC2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013510</name>
        <name evidence="1" type="ORF">HUG17_1115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQC2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7645577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8287" checksum="A939991F1FBD8719" modified="2023-02-22" version="1">MSTIGKIPVVKTPLKCLVMKNMVTNRLGRSLIENRHRMSKNNAETGKMANYILLHYNCQLINDRIRFRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQJ3</accession>
    <name>A0A922HQJ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQJ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="81" mass="9420" checksum="5CB46B7BA9CE1DA0" modified="2023-02-22" version="1" fragment="single">THCSDFVVFIYENSIKIRKSGYESIVEGIILSYKWGFHNDFTQPITRYTVEGLKDLLPKCEIIVKAVFVLLNLIQRPIIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRQ7</accession>
    <name>A0A922HRQ7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRQ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6302" checksum="4018174E539F2485" modified="2023-02-22" version="1">MKTRSAGSLAASALSAQKFAVCRKCIRSLPAILYECGNVIRLKRFGDSTLRISTLLGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSB0</accession>
    <name>A0A922HSB0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Golgi phosphoprotein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GOLPH3</name>
        <name evidence="8" type="ORF">DERF_011079</name>
        <name evidence="7" type="ORF">HUG17_5866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSB0"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031985">
        <property type="term" value="C:Golgi cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000004">
        <property type="entry name" value="Probable VPS74-protein involved in protein-vacuolar targeting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7643504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9506341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="284" mass="32850" checksum="B76F38F483029AC2" modified="2023-02-22" version="1">MHRTDGLVQRRVASSTSANNINKENEDNNCYNGDYDSSSKETRLSLMEEVLLLGLKDKEGYTSFWNDCISTGLRGCILVELALRDKIELEKCPGRKRRLLLRKVVIKNSEPTGDALLDEALKHIRETEIPETLQCWIDYLSGETWNLLKLRYQLKNVRERLAKNLVEKGVLTTEKHNFFLFDMTTHPIINMTIKNKILKKVQDSLLSKWVNDPHRMDKRMLSLILLSHSSDVLDNAFMSLSDDDYEVAMKRTRELLELDMEAESQKPNTNELMWAVFAALIKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSK3</accession>
    <name>A0A922HSK3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_012629</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSK3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11405">
        <property type="entry name" value="bHLHzip_MLXIP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21739">
        <property type="entry name" value="NES2-NLS_ChREBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF37">
        <property type="entry name" value="LD38259P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="935"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="755"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="986"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9501816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1161" mass="131273" checksum="581A5760E45817DF" modified="2023-02-22" version="1">MYPSSSSSSSSMTTTTTIYSSISPTNEPLLMVNNTNKMDNNQFNTMTNMANINDGCMINVNSIRRIKPSPKTTKENRIHSGHFMVSEIDENEDNETKIENDDHDVSTTNNNNNNNNSNNNNANNDINQAQQQQSYPSSISMSLMEQKLVTKTKTYRIRKSTTTTRIVSIDQSLWKLFQCMTLAYDDDITSPKWKTFKGLKMNIKDKIRLNNIIWRAWHIQYISGRKPGVCQFSSNIDTERHKKTEAILLEGKYWKRRADVVKAEYNKWRLYYQHLSRSVAAAFSSNNLGSNASRMLPYDWENNLPRWSNNLSLDSLFTCSPSISSAAFNSSSSIIGCPSTINTGNNLTNNNNNNQAMISQNNQNGTMQIFNDNIPSIPYTNYFDYASSREIARSGMGADFMQPGLEQLQPNIDFIDTFEQDFFPLRGQPTLSTVPEETEPGYKEPQEDLLDSLFNSCPTTSTNSNNNNNDLSPKSLQDNNYCQFASANNSPNQQMNQQPLTAVYNPNNYGQPIFNINQPQQQLVQSSYKMEFESTMNTSNNGTSSLFPFHSNKLIQQQQQESNRQLIQMSANNSINYNPMNFAFNPSNTNDNTATIMTTNQQINPITMPLKKLIPNSSQQQSPQSSSTSPIMNLDLKELKNQALSLSCKNISQLQNSISTGDGTLSSSSSSYQIANEPNTLSNIGRSLSLPLDCGIQIPPQQQSLNHNKKFIKSIQQQQQQVTGPIISSMINTSAHNETSSFTNVQMVPATNLTIHKHQQQQQQQQQQHTFVQNQLSPSSSSSSPPQSSIATAAAAFDLSNSSHSQMNRKFPLINNGKKPYSINPRRNIDSNNNFKIRNPLLKNHTTATGSSSSSSLSSTLGSLDYSSFKDRILNGPVNKYFLANNNNNNTSPTHDEMMTTMASFGSYSFPANTISFIGRNEHEHRNLHREHRERRRVCHINAEQKRRCNIKNGFDTLRSLLPSLAQNSNTKISKAAMLHKAADYIRVLKNEKFEQQKEYELLKQQIDNLNHVISIFQNQLPTTGLPIADGPRIGRLKEQYIQYVRQKTNQNWKFWIFSIIMESLLDSYCRQIATNNFDELCKTLFRWLDQGCSLVVLRKDVLNSLRFVSTSTNILTNPELLHDEIIQAISMTTQTTTTTTTMNENKLQGRILPEQSSSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSY1</accession>
    <name>A0A922HSY1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Multiple epidermal growth factor-like domains protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MEGF8_1</name>
        <name evidence="5" type="ORF">DERF_012812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSY1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056737">
        <property type="entry name" value="Beta-prop_ATRN-MKLN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051568">
        <property type="entry name" value="LZTR1/Attractin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46376:SF1">
        <property type="entry name" value="LEUCINE-ZIPPER-LIKE TRANSCRIPTIONAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24981">
        <property type="entry name" value="Beta-prop_ATRN-LZTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Attractin/MKLN-like beta-propeller" evidence="4">
        <location>
            <begin position="273"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9502011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="629" mass="73111" checksum="4395D3C0680A4125" modified="2023-02-22" version="1">MKRPFIGKYNFILFSFIIWISFSFILDSYAISDYYRRIISSNDTIFGTITNDRDGEHEWLFKTNDPLSIIKFINIQFIWINLSTCNSTTDTIYLFNGDSYEDRLIGSIHGPFYGQSSQLKPFVGNRNRLLMIYHRQSSSYDDLPTFSLQYSFTNCPLNCTNNGHCINNQCHCNDHYGGDACDLDTRTEYDCPTKRIGSSCNININDVQSTKWFELFSNQHIFSARASHDSVYDRHTDQIYTFGGRSYESIYGDLLSFSITKNKWFNLTDCDNKNTYNNTNNNSTNQPKPRWGHTMNIINDSLIIFGGIGADGHQFNDLWIYNLTNCRWIQSIDNNIPALAFHVAIIVDNEWLHIHGGRFENSTYSSNIYRINLLSSSNYQWELVRSLNKGRTLAAHTAIVYNRSIIVFGGISGTNGKLSNAMYQYDIDHNYWSKLRYSQETKKNVVVPEKRAFHSMILVDDDDDDYLVIFGGFIQNNDCLGDGSLTYAFSLKSRYWTKLNDISEKFPFKSIISHTLVRRKNLLFIIGGYYGQIRNEIFVTQLHWNSSSYFHHHHHVDNKNSELIIWKYFNVPNISMPDVMTIQTVDQMTIPCQLLPNEQMIRIFGFIHPFGAQTFDKNSLRIYLHNDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSZ3</accession>
    <name>A0A922HSZ3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase</fullName>
            <ecNumber evidence="9">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">REV3L_1</name>
        <name evidence="14" type="ORF">DERF_012637</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="9"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056447">
        <property type="entry name" value="REV3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24065">
        <property type="entry name" value="REV3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase zeta catalytic subunit N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="12">
        <location>
            <begin position="66"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="11">
        <location>
            <begin position="497"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="10">
        <location>
            <begin position="772"/>
            <end position="1242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9501824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1392" mass="162972" checksum="F6FE0157424187BF" modified="2023-02-22" version="1">MNIIHGHNCFRITFFHIDSYITKPDLVLDETYSSFRKRNINLATIIRVFGTTDDGISTCIHIHQHFPHLTVRREDLFECYRIESAKESTVDHTAILDVFVKDLENSLSQFVDSRSQDEIQIINVEPHDSFSFYGYHDRPETFYRIYFTTYWMANQAKNSLESGMINGYKFVCYNFLEFLLQFYIDRHVYLNTLTFKQITFRKHRSSNVYEDIDCIRDRQFTTVAKILSYNDLIITSTCQFECDALADDIMIVEHQPLFPSNELFNPSMPGIISLWNRQFQRSSPEEFQSLLKCIAKHHIFDINPNIPQLDGPTDSEDVNYYLFNGKQIHFDPKQFQKGIVCAPRLNPQSGNFPILKFMDKSPGNIPLIMERSHLTTISNTDTKHEMFESIERKINTFHRTSDYMEKLKSRLKTYRLSNPILETDTDTDINRPKSTSCPLKLHFKNKCNVPKISLPESTITRKRRNPFDKNPAIQDIQLDNLITDSNLMMMANSFSTTVHTMNSSLMNDSNQFEMTKSNELSIRSNHFEWIQYPHLTIMSMELHARIRSNLTPDPNYDPIQMIMFTIHWESIHDSSSAQKPYMAAIIVNKPDVKNVEHCLNWKNRSINIDYVQSELDLFFRFSRYVQQSDPDIVLGYVVDTQSWGYLLQRAIILGFQIGPMFSRVINTFQSKGNSAGGQNESPSLVGRIVLNTWHLLRHELALRSYTIENVYHHLFGMTMSKLSNESLGQLWESASDLILEYYLQRTLGSMRILNHLNYIRRTFDLSCAFGMPFLDVIERGTQFRVESMLLPLCRQANYLPLRFSKHFIRLQRAPQYISLIYEPDIRIHLEPVAILDFQSLYPSLIIAHNYCYSTCLGRLQNIISKDDTFGCYKLKNQQQILDGLSDDQIHISENGVVFVRRNVRQGILPKMLEEILNTRILIKRELKNVDRKLKNPELSRSERKRLQALLNELDNSQLAMKLISNVTYGYTSANFSGRMPCIEIADSIVSKGRQTLEEVITFINQWGQKSGSKVKVIYGDTDSVFISFPGHSLSAAFEMANFFITEINRRQPYPICLKLEKIYQPCIIMAKKRYCGYAFDSATDQARFDAKGIETIRRDGCPLTGKIMERCIRILFDSNGNVESLKPYLQHQFDRILSGRISQLSDFIFARQFAGLKNYRNGDVIPACIIARKRMQIDPRDEPKIKERVAYVVIDDGDEKRRIADLVRQPFDLLADETLRLNGDYYIRSAIIVPMIRVLDSIFRQSQKCLNGWYEECRIRNKRNRQNLMVGQQLMQQLQQNHQEEFNLMMNNDYWQQQQQRRILTTNDYLEPLIQIMDSIRNVRFKLKNYEQQCCHCMQFDWNHQFKSNSSKHPCQVETCRSLYGYHQCKRDFHYLLFLQQALLNKSITNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HT27</accession>
    <name>A0A922HT27_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HT27"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6890" checksum="B79AECC0CCD1503E" modified="2023-02-22" version="1">MLQAKQIKANISIALDSCNRNLPSNEWDVNHLNFKLQEKVDLDSYTTSSVVTKHYGPKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HT96</accession>
    <name>A0A922HT96_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline/ethanolamine kinase-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_011592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HT96"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9506880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="53401" checksum="DD97010CA16858EF" modified="2023-02-22" version="1">MLVEQFNSCSNSSSSRNTINETNDNNNNNSEPTSESSTQMRDRAYEICRKYLSGEWNKISSDDMIFKTVSGGLSNLLYYCSLPATHTPVTGEPSQVLLRMYGQLLDRYDTKITDSVITMLLSERKLGPKLYGIFPGGRLEEYIPARAMVCNELSDPLYSAIIARKLAIVHHLNVPINKEPTWLSELFDLWLKQTRKLEKEISTTTTSSSSSSSEISKIEQELIRFDFENEIKILFRILDQCESPVVFCHNDLQEGNILLPSDDKHLSKLLNNNVSESTITTTTTATATTTKSDGDNVNDNDDNDNGQRLNGNGKQQKQRRSDFDDHIVFIDFEFCSYNYRGFDLANHFVERMFDYSNSEWPHYFAYMDRFPNDDEKRHFIREYLKQCSELSTPIPLLDNEEHLIKEVDFYALATHLLWTLWGITNARTSKISFGYMEYGKTRLEAYHMHKKFVLEKYCLKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTA8</accession>
    <name>A0A922HTA8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Nudix (Nucleoside diphosphate linked moiety X)-type motif 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NUDT8_1</name>
        <name evidence="17" type="ORF">DERF_012346</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTA8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="16">
        <location>
            <begin position="217"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="395"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9501502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="448" mass="51166" checksum="F00D18A12D996A63" modified="2023-02-22" version="1">MAKYLAQIIVIGAQAIGRAFTRALKQEIEASQRAAQQRNTNNSSAASAAANAKLGMSVQEAMQILNIESNQLNDLEFIEKRFKHLFEVNDKAKGGSFYLQSKTSMMVYETMTLKRMMMRMTMFGSKFFTTNNLYCCFHNNIRSTTFNRQKPFDNNNNHYNIHYIQQRTMATTTSTTITNEKLIEDIDRNINEQNLRKCIERMKRIRLGGRLRSDSTMKNASVFVPFCHDLTTNEPAILFTRRSFTMTKHKGEVCFPGGLEEECDESLIESAIRETIEEIGVNRSDLKVYGELNPIPFNDLALYPVLGYLKLHNTLDQFKLNPDEVQSIHIIPITRLLNMKFWFKTHWRSGWTTPVYKDDENPRIWGMTGSILYMLLANIFHGHFQFDSSYLNRGPTSPSSATSSSSSSSPPSSASQSADKRIDEELQTLQQQQQSSKKNGHQSKSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTC6</accession>
    <name>A0A922HTC6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTC6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="77" mass="9304" checksum="B892845CF89FA49F" modified="2023-02-22" version="1">MFYELPIDLRIEYLTNIYRINHSLPVTWLNDCRFQLDIIIIIFLLMVPKCLRCGRFSQFASILGCESEIFFRDRKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUB7</accession>
    <name>A0A922HUB7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BUD31 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bud31</name>
        <name evidence="6" type="ORF">DERF_011122</name>
        <name evidence="5" type="ORF">HUG17_5903</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUB7"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00997">
        <property type="entry name" value="G10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00998">
        <property type="entry name" value="G10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7643541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9506384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="148" mass="17581" checksum="86ECCCA7EDCD6CCD" modified="2023-02-22" version="1">MPKIRTVRNRNRQPPEGWDLIEPTIEELEAKMREAESESHEGKRRTESLWPIFKIHHQKSRYIYELYYKRQSISKELYEYCIKNRIADAALIAKWKKQGYENLCCLRCIQVRDTNFGTNCICRVPRDKLEEGRKIVECIHCGCRGCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV51</accession>
    <name>A0A922HV51_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IQ motif and S7 domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IQSEC1_2</name>
        <name evidence="2" type="ORF">DERF_010058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV51"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="377" mass="41340" checksum="C2D737C2E36A3FBF" modified="2023-02-22" version="1">MNRNSAINLQLSPTKTIATAPMTPIPSSPSTTTTTNLIRTQRITGGSQTSLSSNSNNNHNENINNNNKSSSSSSSIVAAASASALSTYEISQQLLDKKVSALERKYGGQRAREAAIKIQRSYRSYRLQKRFTSLAIQAIHFQQQQKQQKQQQQQQQQQQQQHPENLIINNNLIDNENGLYHYPHHHYYNNHTQQDSYNNQMIKSIRSSSITLLQRQSDGNYPQHPLSLPTLPPPSSSSSAPTPPPPPPPPPSSSSSASSSIYGINNHNKQMPPSIIYSPSSIDQNNGVIIIDNNNNDDVDNDETVKQQQQQQQSMILLDSRLKKKKQSSSSFSSISSNGSSSSSSTATSISALSSSVSTTATKTSITIKNIYNNGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW91</accession>
    <name>A0A922HW91_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW91"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="69" mass="8328" checksum="01AB792809EB1779" modified="2023-02-22" version="1">MTINFFSNGRFEREIELSNQKHSKELSRISTPLLFSHFHFGYFLFGYSISQPHLMIQKKFLQLKQLKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWL4</accession>
    <name>A0A922HWL4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_010164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWL4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="282" mass="33021" checksum="E010135D89D03DF1" modified="2023-02-22" version="1">MMATTSVYYMTCIICFLNIFIIQLIQMYPNNKFPAADDDYHTILAQSMNQDYHHHRYRPQQHRPIMIPNSNHRRPHIRSDVHKILVEKLSSPTSTTNEHRSQQQHHTQCNATVISSSRLLIPNECAPNGNHMETIQIYPVNNTNDKIIRRNGRTIFRLQRTKNSLVELNETIPGSNDNNRPEYRQEPQQQQYPSNAIDMINNNVNEPYYNEFGDEQLDGRQFLPPFIAPPFVAPPIISPLPIIPGFAYEYEYFEYQWCRPYAIEISICELCVWVPTVCPIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXC9</accession>
    <name>A0A922HXC9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXC9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9515793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="78" mass="9134" checksum="1B815DBC110A309F" modified="2023-02-22" version="1">MLCIIKKIVWQKKNKNIPVVMDNEAFTPPTLSNKLTKVKVGKKSFNNNNNNNEYIFDDDEKTHEHNERCENSINNNMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HY99</accession>
    <name>A0A922HY99_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HY99"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="195" mass="22483" checksum="89BF697C4F24296D" modified="2023-02-22" version="1">MFNLIRLAMRIYDQAINRQNSPEPSRPKPRMPFRRYNSCSILQNLPTKQNPVDSVSVLLELGPLSSSDSNLFKKPYPVKKNSKTPFVFKKPDKNKTPILLFQKKTDTKPINEVKLKKLKKLIKPIEPIKEYYYFPPTKTPEFVVEETIISEAPIQSNPDLHSDKLTTEMDYDSGDETKIGKEYCISSNSDVMINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYA3</accession>
    <name>A0A922HYA3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Programmed cell death protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PDCD5</name>
        <name evidence="3" type="ORF">DERF_009578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYA3"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="145" mass="16703" checksum="B7601AF917DD8FAA" modified="2023-02-22" version="1">MADPELEAIRARRLQELQMQYQGKGSGMSGPGQMNMQEQQRATQERQEREEELRNTILTQILSQEARARLSTIALAKPDRAKMLENILITNAQRGAIREKLSEEQLINFLEQVNEQTSKKKTVVTYDRRKTAIDDPDDDDDDNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYE8</accession>
    <name>A0A922HYE8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYE8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9512028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="399" mass="48353" checksum="FE636527F03434B4" modified="2023-02-22" version="1">MNKMIEIFRKNFLSIRIISIGIVRMISPLLRLDGLNYMKRYFDMYNDQQRQCKQFDCDQISKQFRLSWIGQHHHEKCSICQVIQYYLHRLYYRNQSVSILNAVLFQQDRQQFHPPYRYRTRMAGKVVKDIAMMMIKMVNLFMIITILIIISMELLLLKFILENLDYFFAIFNRPIFVSLNHAMWLMLMSFFWRLYEFFIIIYAHCCALFALCLLLFMMIFLINVWQTKQLLINLRWITIFQRLKRFQHFNTYNLKLIQWGNVYCEAVTVFIFVNIPINCYIVLYILSGCSNWFYSFILSIIACQQILCIFGVHLMFAICNNNFQESSTRFLNLLARESCRQSRVKNLSLLLKISNYGHAYHTENKYGFTYGKLQLISMREFLMFLLLYCQFIMFFFQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYY4</accession>
    <name>A0A922HYY4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYY4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="109" mass="12951" checksum="6B0A59220ADF8BA7" modified="2023-02-22" version="1">MSHHHCSMTQGNVFDHNDDRKLPELKIIFTFTNNDRSIHHHCDDLIDRSSFFYSIRRKKFAISSPNDEFYDDCVETATNPKTGQIKIFFKQTMITHNKDQNYPVEKEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZD3</accession>
    <name>A0A922HZD3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZD3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9512059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="79" mass="8876" checksum="62BE3A2809FF4C70" modified="2023-02-22" version="1">MQILHKMNEYNVFFLTADSLYSLFLIDSAQLLNALKKILYIQRKKNVPNGTISAPMILDSRILILDTNKGDSSSSSITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZE2</accession>
    <name>A0A922HZE2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Luc7-like protein 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">RNA-binding protein Luc7-like 1, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LUC7L_1</name>
        <name evidence="4" type="ORF">DERF_006943</name>
        <name evidence="3" type="ORF">HUG17_1463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZE2"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7645925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9516187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="325" mass="37658" checksum="FB03E3C6A8AB741E" modified="2023-02-22" version="1">MSATEQMRAMLDQLMGTSRVGPDDKQRSTKYRFTDSQVCKSFLLNCCPHEILASTRMDIGECPKVHEFALRADYNKASKTQHYGYELNAFEHLSQFVADADRRTEVAKKRLAETQEELSVEASEKLNRVHELAEAIGKKLAAAEAAGSEGNVEESLRLMEEVEKIKKEKNAAETEYKSSIPTSSYQQQKLRVCEVCSAYLGIQDNDRRLADHFGGKLHLGFITIREKLEELRELVETNRKKGVYKQLKRDGNTSHERGSSRYDSDRSGRSSRYDNDRRRRSRSRSKEYPERDRDRNERRSHQNRNRYSDRGGSSHRDRSHRNGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZH5</accession>
    <name>A0A922HZH5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-N-acetylglucosamine 4-epimerase</fullName>
            <ecNumber evidence="7">5.1.3.2</ecNumber>
            <ecNumber evidence="6">5.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_006672</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:20517"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="5.1.3.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="7"/>
    <dbReference type="EC" id="5.1.3.7" evidence="6"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZH5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003974">
        <property type="term" value="F:UDP-N-acetylglucosamine 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="12">
        <location>
            <begin position="9"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9515897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="436" mass="49536" checksum="8443D7FD5B6F34F9" modified="2023-02-22" version="1">MNNYNKLILVTGAAGYVGSHCLVELLNNNYDVVVIDNCSNSIQLSGENLPESLIRVQSITGRQLVKFYKEDINNVTKLEEIFTKHRFVAVMHFAALKAVGESCKIPLDYYRNNVSGTIILLEVMRKFGVKKFIFSSSATVYGHPDYLPIDENHQTGNGCTNPYGRTKYFIEEILKDLCASEKGWCVASLRYFNPVGAHESGEIGEDPQGIPNNLMPYISQVAVRRQPFLRVFGNDFKTADGTGVRDYIHIMDLAAGHSITLENVLKKEWTGWNVYNFGAGTGYSVLDVITAFEESTGVNIPYKICNRRAGDVDELWADIGKAQNKLNWKPKWTLRDMCAHSWKWQSKYPMGYRTLLNIQQQQHNTNEGNLNGNIKTINDIDDNFIQFTSQQQRKEHFLDIPMMDNKMTNGISLKTKIFKGKRFALEVNNNEEDIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZP4</accession>
    <name>A0A922HZP4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZP4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="35" mass="3817" checksum="2BF10A5CDF752920" modified="2023-02-22" version="1">MNESNESDIPSSSTPPLQSEMDALLLGRIKTNNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0V2</accession>
    <name>A0A922I0V2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein transport protein bet1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BET1</name>
        <name evidence="11" type="ORF">DERF_008382</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0V2"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9517743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="107" mass="12688" checksum="E55F7F9D8EFA4FE1" modified="2023-02-22" version="1">MARRYPHSNEDFFSTHIQGNENNDLISGLRNQVNELKSLSLDIGDEIKEHNRFLKDMDNDFDSTWGSLTNSMARLKKIASSGNHRYIWYLLLFSLFVFFIIWLIIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0Z9</accession>
    <name>A0A922I0Z9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Low-density lipoprotein receptor- protein 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LRP1B</name>
        <name evidence="18" type="ORF">DERF_007283</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000007">
        <property type="entry name" value="Low density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1220.10">
        <property type="entry name" value="EGF-type module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="26"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
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    <sequence length="5087" mass="579342" checksum="2CA159FB38DEA113" modified="2023-02-22" version="1">[encoded data, 5087 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1K1</accession>
    <name>A0A922I1K1_DERFA</name>
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        <recommendedName>
            <fullName evidence="3 14">Exonuclease 1</fullName>
            <ecNumber evidence="14">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="19" type="primary">EXO1</name>
        <name evidence="19" type="ORF">DERF_007115</name>
        <name evidence="18" type="ORF">HUG17_1582</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="14"/>
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        <property type="protein sequence ID" value="KAH7646044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KAH9516376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="26491at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="14 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="16">
        <location>
            <begin position="138"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="392"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="469"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="531"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU910737"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7646044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9516376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="607" mass="69804" checksum="A0B279F1F48CD09D" modified="2023-02-22" version="1">MGIQGLLPLMKGAETTVSLSRLQDTVAAVDTNGWIHRACYSCADRIYMGEPTEMFIHYCLNFCKILEKHRITPILVFDGQSLPAKSETKLARQKRKQEKREEIEVLLRKGRESEARWLMRQCVDVTFEMCRQVIERCRQKQIDCLVAPFEADAQITYLVNNNLADYAITEDSDLLAFGCKRALYKLDREFERGKMIDMSHLNRCFKNLNLRKFQLMCILSGCDYVSNIPGIGIGRARKFFESFIEDPTAENMHVILQKLPSVLKMNGKINVTNDYIEDFIRASNTFDHQIVYSPQFDRLVYLNPLKQNIDPNELKLYGGNFFSNGEEKLDNNLKFVTNYVLGNVCPKTLSILDSFIPQSLTIWHSPEFNERIRSQMSNRNLELIIQNGDKKEEKRISKISPSKVKSPKLKNNGNEIIDSGKSEKNENDTNRKTKTSIQRRYTRNVFRKRTVVDDGIVKKSKYFLHEKIDEQTDNSDAESYLPQPKKSRPESLQISTEELNQSFSSIEEEEVRTLQLLNSCQIDKPIAKSSYRQSYSLSSTQTSQSTSTSNSPTELQMSSSDLFNKLITLSNTPDRNVSKKNTRTKSSSSETKITATDIRKFFPKISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1Q1</accession>
    <name>A0A922I1Q1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1Q1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="244" mass="28383" checksum="185949073FAD5F9C" modified="2023-02-22" version="1">MPQKISIKNKKTKSSPQTSFHELYNDDDIDDEEPDSSPWSLDSDDDVDDDEDFDDEQTAKNRNDNEGGGGDDDDDVDDNNTSNNDDENNYKKLEKFQRPIPKWPVWNKMGIPSLAPLPMPPESSSSSSSYTNDPVTKPIINFYHHQYTSDSPELVSKNNNNDSERHRENIVHRIPTTSSNKNFIGNNNYNPHHHHHHHHPHRHNNNNEINNNPQYKKKKNREQNHSKSSQTKKFFKIVNYNIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1Y7</accession>
    <name>A0A922I1Y7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1Y7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="477" mass="55169" checksum="E74022A8FAE594FE" modified="2023-02-22" version="1">MVTIGEEKKKYRNQNQAGFVDSIRMNSTPQDLNSLLENLKKFIIFSNNNHDLNNGEMIRPITNDNNDDDDNSIGQQRKKSISSINLTNQNLDKSFTPKIIMTDNNHRRKCSKSSNDLSTIFNHNNQHKDDSDHDQNQSNNKEISTMNRKSANLISTPSLSASSSSSSTIKLPKSNDSDFFWPSTSSSSSWPFGETVATNYRRFARNRDPEFSIDDVEKKRQKAREYKQQLEQQMKEKCQKMNRVQQIERVENELLDQKIRLQQAKMREEFDKEHHTESVTKENNDNHHNHRRSLKSPSVQSMKMRRSSSVASLINYLDINNSDNDNNDVDDDNGKQNRIERKTLSSAKLPRLESRMAGSKRCNNRTVSTQTDISLLAALFDQINTNDRNQINQISIQSSSLSAKSVHSPLNHQSDQRTKQQQEQKNPPHHHYHHHHHQRRYNNNHHHRNHHRTLAKSLTNLNASSSSSSSLKDSQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I305</accession>
    <name>A0A922I305_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I305"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037020310" evidence="2">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9521071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="308" mass="30838" checksum="1940F63382DDAED4" modified="2023-02-22" version="1">MMFFIVLISAVLANASYGSKGSSGGGGGGYGGGSSAGYASLGGYGGGRGGNAAAFAGGMKHEHDCFRMSTIKIVISGIIPAAIQTSHNIEFREVPSTGSVQPAVIEVGSQSLPVMILFRSSSSTLNVQQMHDSAQGSVQESSSEGMLIDNEPHRLIHQVTKPVHEVITPFRKITQEIKPVEEEINTIIARNSGFGSGAAAFGNSGAGFGFSAGGGGAGLGLGAMGGGGYSIGGTKSSGLSLGGSLSKSSKASYAAAASSQAVITSSKPSPSSSASSSSSSSLSSASPSSSSSISIIHYQKMVKHHQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3A6</accession>
    <name>A0A922I3A6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_004183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3A6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF81">
        <property type="entry name" value="ENDOPHILIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="60"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="384"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9520475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="462" mass="52765" checksum="0FBF54DD281AF70D" modified="2023-02-22" version="1">MAFFCPVRIRRNKKKHVHLESDLLSGTRHHQSLPPMGRITGSVSIETLVRVGIEKENGLSPNSKMIVLHDFTPCVDDELEVKRGQIINVLYQENDWVYVISADQRDRNGQPTEGFIPASYCAPLLETNIDNLLMNFKKKMPRSGPNSLVDCNFNEINANETNSNMLNNNNNDDQHHHQIDFLGTGNYCNQIVQTQTVHSNRSVTDIIDINNAIKQQQNYQENDQHFMTFQSSLNYQNHHNNGNHHNRYSPTQSHHSFPGIESVSQQQNNSIMNLDLVMATTTNTNTPSTNQTGPLAISMTSAGSNNSQKNGIKSNSNVSSNHNEHLQKRSYITSEDFDSLTNAKSNNHHQANHDQYSKALYLASSNLSNEHSINNVEIQPFFKDQSGRYVMLYTFVARDENDISVERGEIITVLNKDDQDWFWVMRSDSQEGFVPVSFTYPIDLLLICYNCEMFSMLIMFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3C0</accession>
    <name>A0A922I3C0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3C0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="422" mass="48854" checksum="9F6B5F763EC45C9A" modified="2023-02-22" version="1">MDFLADSCLSTSVMDKSYKKPCQTSTRYHFLLAGRYYSPSSLSSTFYYFATQFFRYDQERPNRVVAIPFKEFNYEKYVGKLVKFMKRYRYYAMNLEMFDAVQKKVEALISSPEISSLIKESLRSKFDRANEIAAGFSELIPKRKLDENNAIVKSMHAIRRGEISSANCCSKEFCTRVSLYRHIVANHPNFYVDDGIPQNESPEKNLRKSRSTPSDLASQVNQRVESTGCMEKKSSPMCSTFGVDNHETNLSNQRSSNGEKITGTKIFDHNVNCSPQQQSSSIESMNGSSQALADSNDDNSSVRSLLQQEENRKLLKDYDYQYRCLDLIVKTLKDKKASMLTLHRLTQEVKRVFKDWLFPLNDNFYPLFLFDKDADVHFEFFILDPESPVNITNRSPCSDLRIFELSKLIYSFVYEYCKTISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3Z0</accession>
    <name>A0A922I3Z0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">E2F-associated phosphoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3Z0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019370">
        <property type="entry name" value="E2F-assoc_phosphoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15967:SF0">
        <property type="entry name" value="E2F-ASSOCIATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10238">
        <property type="entry name" value="Eapp_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9518192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38761" checksum="769E921A08F159C6" modified="2023-02-22" version="1">MDQDDCYYEDILDGISDAESSYSSDDDNDNIGNDDNDNRQKQRIVQLKEHLTKETYDILIGNNVNDDVVVDSNEQFENEMYNEARNHVNGVHVVDSNNIIGVIPSTSLCFNKFSEQSSTYNHGQQQTSIIPKDSFISNNPSSSNHNNKLENQINADEKEKILDELFYDPDEDDSNQQWIDKKKFQYESRITSLESDSNVDQDDKQRINKLQSDRRLKKPRSDATLNCPCCLSLLCLDCQRHEIYKTQYRAMFVLNCRIDFERKLFFKNKDELRKKFQKRKKRLQQENKMDEQSSSLTGDQYYPVHCNICNTQVAVYDLDEVYHFFTVIASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I475</accession>
    <name>A0A922I475_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I475"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7609" checksum="F4105E2164810E5A" modified="2023-02-22" version="1">MAADYIDEANLNSNWYWYYVFFLLLAIAMDRNNRKSLRLPPQHYINAKKPECVEQENRNNKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5C5</accession>
    <name>A0A922I5C5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5C5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="121" mass="13958" checksum="B806D888363E8076" modified="2023-02-22" version="1">MELLSSLSFIVFNNSTSVFKNDLTLKFVSHFIVKKIQENLSKTTKYQNPYPSKISPHLWPPPPPPLSSSYENEYINQLLTNIDCVLPSIHPSIHIPIDFVNNRLLLNKTPTIYTFTLTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5I5</accession>
    <name>A0A922I5I5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5I5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="8528" checksum="EEEF9B70180003AC" modified="2023-02-22" version="1" fragment="single">MNMIILINDFDDQLNVYENQHCYDYYYYYVSTISIQNMNQTKTNSFFKFIYYYYDYDNIFCCPQVRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5L2</accession>
    <name>A0A922I5L2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho- BTB domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RHOBTB1</name>
        <name evidence="5" type="ORF">DERF_005555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5L2"/>
    <dbReference type="OrthoDB" id="6020506at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18499">
        <property type="entry name" value="BACK_RHOBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01873">
        <property type="entry name" value="RhoBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000177">
        <property type="entry name" value="Rho-related BTB domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000014">
        <property type="entry name" value="Rho-related BTB domain-containing protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="541"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9521942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="780" mass="90552" checksum="9E24FD68B981F865" modified="2023-02-22" version="1">MRMDYEQSHQELVKCVVVGDTAVGKTRLICAKACNLILDLSQLMTTHIPTVWAIDQYRIHKEVLERSWEVVDGVNVSLRLWDTFGDHDKDRRFAYGRSDVVLLCFSIANPLSLRNCKTVWYPEIRKFCPNTPIVLVGCKNDLRYMFRDEQFQNLCRERSPFFRVNHLCCRFPECGRPLKECDILSPEQGRNMAKEINASYYETSVFTGYGVKQVFENVIRSALIARRQQRFLMTSLKHVRDCLLQEPFLPPKPQLPQLVVPASTYGLDIGSLLNRQAYTDVVFVNHTASKASINCHKIVLITASDMLNTLFTFPPYNRCKAHFGTCIDSVIASAPATTKRLTRCASDISIASSVDDLDKHEPKPFVDDSLLDVRWNHLKYVLSASLFPLLSFDASKLFKHSFSKQKLFSYNRFQQSKHRLKLFQQKLVTIYKHVRQARLDGTSLRSTRQSIISFGDNIPFEALNTYISLLYSFTTTTKPFTYGQLNDLYKCLSYLDFVDFDMSILSLDNFIPNMQHYIETSKYDIFAKRFAFFGIEKGLFSDVIFRLDDGTCYGHKAVLMARCEVMEAMFKGDFRESLAQIIVFPNVAKDTFYSMLFYIYTDMLVDCINHKNCLPLIELANRFCLTRLIGLIEECVVNELSCMCEKQKTDITPAVIRLLEPSQIHNADQLTEFCFHYITTHYNDICHNHTKLLRSLHPENQAYLNRNRWPPVWYLKELDYFERCVREREWQQNPKSYKRRRMSAGCFCFSPSKPKSNRNQLNKATTSTYSGLTYKIIGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6D0</accession>
    <name>A0A922I6D0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6D0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="114" mass="13212" checksum="DA001C4E48511CDB" modified="2023-02-22" version="1">MHVIQVVRAVKVGRLSSLSSSTTIMITKNRSDNITNRLILRVISFIHSSYLFPRNQSRECDDNDDYLKIYFFVFKQPPPTTTTITITITTRTNDDQKQLCVQIGFKKRTKKSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7C6</accession>
    <name>A0A922I7C6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LAMTOR5</name>
        <name evidence="8" type="ORF">DERF_005634</name>
        <name evidence="7" type="ORF">HUG17_3403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LAMTOR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7C6"/>
    <dbReference type="OrthoDB" id="76862at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024135">
        <property type="entry name" value="LAMTOR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13342">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13342:SF2">
        <property type="entry name" value="RAGULATOR COMPLEX PROTEIN LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16672">
        <property type="entry name" value="LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7639370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9522030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="90" mass="9955" checksum="6A9198E6461F95FD" modified="2023-02-22" version="1">MERKIAKICKETLSSESKLGIIVADTNGLCLATDGCGDKNLAPTLLKIIQSANKLDETKQESMAIRIDCVDHYINVKHHNNVIAAVYNHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7X0</accession>
    <name>A0A922I7X0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CB1 cannabinoid receptor-interacting protein 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Cnrip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CNRIP1_1</name>
        <name evidence="2" type="ORF">DERF_000695</name>
        <name evidence="1" type="ORF">HUG17_8454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7X0"/>
    <dbReference type="OrthoDB" id="5920443at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029204">
        <property type="entry name" value="CNRIP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15043">
        <property type="entry name" value="CNRIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7640985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="196" mass="23325" checksum="DD584477C55DFAFF" modified="2023-02-22" version="1">MIKNPAKSIACTIRINDESYSNQHKSIPLYFKEDGQRFLMQQTLKMLTSSPYNFEIHLERIHSQIQLVKVDLGIEPDVYSSTFVDFNLHRRGNHSRSITFIWDSSGKIRPENVRNKQRDFLTISIIFSDMSIIEIRLQIRFYIKPGKHYRWGEELDHCKGEIIYNIDNDRPCDMIIMPTLYAKPKYFHLLQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I877</accession>
    <name>A0A922I877_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Senescence-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I877"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13603" checksum="9A90A62C7F7289EA" modified="2023-02-22" version="1">MIGRADIEGSKSDVAMNAWPPQASYPCGSIGRAFAVRIRTGNQDQASFCPFTLREVSVLTELALGHLRYLLTDVPPQSNSPPGSVLDQDRAEYVPETRKGNRSRSLNARNVVLLRPVSFQSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9J9</accession>
    <name>A0A922I9J9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PFDN4</name>
        <name evidence="7" type="ORF">DERF_005505</name>
        <name evidence="6" type="ORF">HUG17_3504</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9J9"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7639471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9521883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="158" mass="18024" checksum="380009646DA7B9F8" modified="2023-02-22" version="1">MILSPAASETKQQIDVTAEDQQMINRFARLNLKSDELQNKYGELKRQEENLEEAENELMLQDDFGDDEDFGDDTNSGTKQDQQSIKPSSNIQFVVGTSFMAVSKTECERLIDQRKAEIKKKMKDLDDQLAPMKEEMNSIKSKLYAKFGSNINLDSEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA49</accession>
    <name>A0A922IA49_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 9">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_006323</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 9"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA49"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9522764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="585" mass="66739" checksum="7F2BF7E56E4BA5C9" modified="2023-02-22" version="1">MENKSNTQLLMFGPKGLIESGQRSSTVADNCLTKDPMFQKLRQYHDECANTMVMNDMFDNDPKRFEKFHLKLSTPYYGFLLFDYSKNLIDDTIMKGLLELAQSRGVESMRDRMFMGEKINFTENRAVLHIALRNRSNRPIMVDGQNVMIDVNRVLNKMQEFSQQIIDGVWTGYSGKKITDIVNIGIGGSDLGPVMVTEALKHYQKGPNVHFVSNIDGTHLHETLKKLNPETTLFIIASKTFTTQETITNAESARDWFLKHAHDKSHVAKHFVALSTNKEKVTEFGIDSNSMFEFWDWVGGRYSLWSAIGLSICLFIGFDQFEQLLEGAHFIDEHFRRAPLAQNLPVLMALLGVWYINFYDAETQAILPYDQYLHRFAAYFQQGDMESNGKYVTRSGQTVNYRTGPIVWGEPGTNGQHAFYQLIHQGTRLIPCDFIAPIKTLNPIRGGLHHTILLANYLAQTEALMRGKSSEQAEKELRDQGKNDEEIKKILPHKIFEGNRPTNSFLLDVISPFNLGALIASYEHKIFVQGVIWDINSYDQWGVELGKQLAKTIEKELQSKDLLIDTHDCSTNALINMIKNIDNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAA2</accession>
    <name>A0A922IAA2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_005820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAA2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000019">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038157912" description="Peptidyl-prolyl cis-trans isomerase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9522228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="209" mass="22792" checksum="ABE8CAE6FDE585E8" modified="2023-02-22" version="1">MFHFLTFQLCLSTIIFSITTLSSSLANGKQVDVTEEAIFDLSIGGKPVGTIVIGLFGRDVPKTVANFARLSSAQGFQGKTYRNSRFHRIIPNFMIQGGDIIRGDGRGSFSIYGGRFADENFNIKHTEAGLLSMANSGPDTNGSQFFITLVPTPWLDGKHVVFGKVVSGMEVVNQIAAVQRDANDRPLEDVIITRSVTRPVNARLIIPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAP0</accession>
    <name>A0A922IAP0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAP0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="387" mass="46443" checksum="C85901ED641BAD92" modified="2023-02-22" version="1">MKNYYNTTSIQKQQQNDRPSLRLNVNVDSSLNRRSKSSSSSPLTATRSNYSPFFSLNYNAERLFPLRKKIYIGKIKHIHNRTSDDDDYYDDDDDYPEHFKWIDYGNMKPKQIEAIKSFCCNQSILFILALIIYALWHSVFYKNLNDLDRQTIEFWFTDFNEIQTKNLIEQFKHQRRLSNDKIELFDSWIIMIVLFSSMIFIFGMVAMCYRSHNNTRAMKIYRWIVIPMLIIIIIALLVFTMFLFKFWIRFANGSSIRFIYDHYNDHDNHRWLMIYVHHTNQWLNCCDWFYLLHQQVSHNNNNNNSNNIQHGHSMNDTIPLSCCKELNHYDHSWNSLKYFFPQQQQQQQRQQQNNITNNSSSIENNNNNDDDNDQKSLVFGGKNSTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB35</accession>
    <name>A0A922IB35_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HMG (High mobility group) box SOX-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SOX14</name>
        <name evidence="7" type="ORF">DERF_001038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB35"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF324">
        <property type="entry name" value="SOX DOMAIN-CONTAINING PROTEIN DICHAETE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9526986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="357" mass="40314" checksum="F6FECF3F9800CC6B" modified="2023-02-22" version="1">MNHHHHDHVKRPMNAFMVWSRGQRRKMAQEHPKMHNSEISKRLGADWKQLSEMEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKPSSSSTSSSTSSSSSSSSVSNISSTASPSANNTLLNNHHHHHHNLKKDYITSPISMSNSYTTQQSNNNSPYNISAAAAAAAAFVDPLRGLSTNTIFTNGHYNNHHQHHGHHHGQQQQQQQQNHHLQQNNFLNNLNNEQQQQQSNESEKAVTARSFPATLHTQNHHQNNDIFNNFFNNHPGSFYNTTSSLLSTLSNVAAQNPNNPYNQIGTNYGLTATTTPPTTVTTNGTMNPSNPLTSFNDFRNNPFAAAYLMMKPEERLSSLAKLSPPQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBJ7</accession>
    <name>A0A922IBJ7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001994</name>
        <name evidence="2" type="ORF">HUG17_6948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBJ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7636742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="445" mass="54315" checksum="CFA46A9A9D8CB6F8" modified="2023-02-22" version="1">MDLLEFSPYKVKKINEIFHIFFNNSLFYVQRYYYSMQEYVKHNITFTWRRLLLPTWLAVNAWSMIIFFILVVFRKLPDYTFLVEIPLTVMKINNFDLLVYYVLLTYSLWEIKWMSTFRLIINYKLPFNSICLSYWRIRDCRLNRKNDEKYLINFFIKSSYTCGTIFRLSVFGLIPLWIMFLKYLSSLYMKQVISLRQFLVCSTMLIACYIKAVHIIGELIIEMLFLLFTAEYLKIHIQRTIKLLSLWIIFASRYRMLPQYYWRQYVIAFSRIGRFRVASKPFLMQIEMVTKISFTMAILFYWQQSQINIFNGFITLVFVSMFCFPQFLYLRLTMFPYYNECFYKLMFSLNARKQLRMQQLQTNRNISKRSQRVYKIMDRLNLREMIMRNLQTQIACKNEFGFYCGPFFFITRAKFAEMFIANFVFAIMVYKKICLYNVNLDILNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBN8</accession>
    <name>A0A922IBN8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_002052</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBN8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="9">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9528080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="96" mass="11073" checksum="FBC107CB787D9469" modified="2023-02-22" version="1">MGKHRNSNRQKNNDVIIIINDKCLDPISMECPYCHLNIVTRIRYMNGLLTYILCCGLLLVGCWYGCCLIPFCMPACQDVEHYCPKCGMIIHNAYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBZ8</accession>
    <name>A0A922IBZ8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBZ8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6997" checksum="BC8F152300CFAFEB" modified="2023-02-22" version="1">MNVFHKNGLRLIRLNVNTFHVRQTQQKKTSGHCQCYGQLAFEGFMLQIIDDDDDDDGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC14</accession>
    <name>A0A922IC14_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC14"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="21121" checksum="20C837C4D12652FD" modified="2023-02-22" version="1">MDDHHHHHHQLQHHYFSVQERVACCFWFDISRSTDDVQEKFQKRFGHGMKKCCPPSRQEIRLWYQRFIKTGCLIHDDNGNLDDDENVESMTNNNNGLHCPHNDHHHHHDCILNSNVVATTTKNGNSNTNLTIENGVIDKEDGKKRVTRIGRPRKCLKKSKQRPPLMTNGKKRNSKRKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC73</accession>
    <name>A0A922IC73_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">Cht6_1</name>
        <name evidence="17" type="ORF">DERF_002742</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02872">
        <property type="entry name" value="GH18_chitolectin_chitotriosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.140.10:FF:000005">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000007">
        <property type="entry name" value="Acidic mammalian chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000004">
        <property type="entry name" value="Chitinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF399">
        <property type="entry name" value="CHITINASE 6, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="16">
        <location>
            <begin position="73"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="15">
        <location>
            <begin position="552"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="15">
        <location>
            <begin position="1250"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="635"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="976"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1150"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="512"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="635"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1033"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1177"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1200"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9528826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1313" mass="146708" checksum="EBD9A13BA37178AE" modified="2023-02-22" version="1">MINIVSTLPLATIITIIVLAIFFNILQLSLAIDNNDDDGQQTTSSLSNTNVHNITKRSSSSSLSLSNDQNENVKLICYYSNWAIYRPGVARFTPQNINPFLCTHLIYAFAGLSSKYELKAFDPYNDINQGNYKKFVGLKKYNNQLKTMIAIGGWNEGSKRFSKLVANTDLRFNFIKSVLKFLREHDFDGIDFDWEYPAFREGSAPEDKEGYAKLIRELRFAFNNEKIPTGKERLLLSVAVPAGQDYIDQGFDVPVISQYADFLNVLSYDYHTSFDPETDHHAPLNSKPDIIDTEALKLNAEWTINYYLKLGAPREKLILGIPTYGRSFTLADENNNGINALAEGPGEPGPSTREKGYLAFYEICQKVEDDDWQLHRPHPHIEGPYAVKGKQWVAFDDIEIIQDKAKFIIDQGLGGAMVWTLDNDDFRGNCYGEQNPLISSLRTSLINPLLQVSPKPAASRDSTSSIRPSSSRENNFIRNRSRPVNFELSESGLNALNVNTRRNQRRKQYFSTSTTTTTTTTTTTTTTPAPTTALALLYTTPEPPTTPDPGIEFNCEDEGFFNNPKDCRKYFWCLDSGPANLGIVAHSFTCPSGLYFNSKTEACDYQENVSCRNKKDKSTITTRRPRIRPKIATTSSPITTTTTTTTTPPPTTTTTQMPITGPPPSSYERDNDEKMMMDTMRKFNDAAKNGNQDELVQLSNLIKALGGIDKLEAILKGFNNNNNDNDRKPLNSEQDDGSASNFFAYVTPKRTQEPITTTPAPARQDRSKPIRQRRPQFLDSEATATTMATTATTPIPPTTLSLFTYYEKPKSNGRNNNNNGGGGSNTNLEAESIDNFVKKSNAKPFEFNYNQPEGRNMMINAFNDMQNSRRLILEENKQKFSNESLTSAVLIDPNTRQIFKLPYQLMPSDNPPNNNRALPSDIIDNSLTARQKDPAMTISRRIRLPHPNTMHQFSTAVLVPDKAGVVYEDEFLFDHQSSSDNRMSGPQPPPSLMQPGQFLPPGSELPLSAYLRQFQPAPPPPYQLPNNDIGHNSQSSSKPKQSQHAQHQRRKPQNQFNIPLQQENPINLLINTPPRAAEDNKLPFNILHTTSLPLTTTPSPVPKFTNYNTLPPEFDISPFTSTSSLYNPIQANNFQKNRLSDLLDSVTATLSSSSSHPTTPIPTALITNDDPILHSLGPRRRIARPRRPLPGIHHHHNHHNQSPTTSSHATAPRTTTTTTTTTTTTTRRPYIAPSIDTFHGPSVYSNNDGGLGCSKRGVFAHPESCGMFVVCAPAGRGKKGFRTLTHHCPADQVFVEEVGRCRPGNKDRCEVYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICE2</accession>
    <name>A0A922ICE2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICE2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="203" mass="22967" checksum="4FF87C2C280852F2" modified="2023-02-22" version="1">MAAVEAQTKTEHYNEIMNCGHNDDYDEGYSSKYNLDLVDFMSNDGTSSLNHPSNQQMIDKDNLSSSHRSINNSSQINSYNPQYSMLSLSKSQIRPELYQLAFDVQMDHDDHDEDDDDQQASSSDWSTVIIDESPITSYPQPIKSSKLRNTEPRTLVVTHDPKIGQNRTGIWMTKATQFYPTASSFIRGTNMVTSQPVCCCCIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICH7</accession>
    <name>A0A922ICH7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICH7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7690" checksum="2F4E808BD14F348F" modified="2023-02-22" version="1">MKMFQICSDKKFSFSLIADAIWFLFVDDVYKYIILSLDRNIINMDNGKIFYHIQTLIVINKHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICJ6</accession>
    <name>A0A922ICJ6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002265</name>
        <name evidence="2" type="ORF">HUG17_10229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICJ6"/>
    <dbReference type="OrthoDB" id="6499963at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7636259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="202" mass="22651" checksum="B06B8FB8F6930D3F" modified="2023-02-22" version="1">MNRQINYPSGFKCRKWTLVILISIDLLVLILTTIALVQRNGSGDDINPDDRNTTSKIPTLSQITNAVNTVGENLAKLNITRINVDLGSIDNNSTRQFLDGILNKARENEGQTKWVGQIVAIVIGFIICLIGLIGVFMENYCLSMTYAVITFVGLLYTTVVGIYSEEPILIGKIIMYILFILLVAWFIIDLRAIRRQQKSQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEC7</accession>
    <name>A0A922IEC7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Partitioning defective 6 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PARD6B</name>
        <name evidence="15" type="ORF">DERF_002426</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEC7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06718">
        <property type="entry name" value="PDZ_Par6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000031">
        <property type="entry name" value="Partitioning defective 6 homolog alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000030">
        <property type="entry name" value="Partitioning defective 6 homolog beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051741">
        <property type="entry name" value="PAR6_homolog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102:SF11">
        <property type="entry name" value="LD29223P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14102">
        <property type="entry name" value="PAR-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="PB1" evidence="14">
        <location>
            <begin position="128"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="13">
        <location>
            <begin position="271"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="368"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="473"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="598"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="653"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="602"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="653"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9528480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="698" mass="77372" checksum="5D3F038535113AC5" modified="2023-02-22" version="1">MTTVPVNSSNTSSTSSSSSSSSSSSSTTSNNSNNIRHHHHHLNHNHGGSSGGGVNSFQHQQQQHTINIGTNKNSNNIGIRNSSAMANFSTTANSNHHHQQQQQQQQQQQTHSPFTNLTNNHHNHQQNLIEIKSKFEAEFRRFSIQRSEITNLEDFVKLIEHFHNLFSIPFCLFYTDPIHGDLLPINNDTNFALAIASAKPLLRLIVQRKGEKSESIDYLNNYGKKKNFLGNILPAVSSSSSKNRLAISAPEDFRQVSSIIDVDIVPETCRRVRLVKHGSDKPLGFYIRDGSSFRITEHGLEKVPGIFISRLVPGGLAESTGLLAVNDEVLEVNGIEVNGKSLDQVTDMMVANSSNLIITIRPANQRAHAAGHHNTLSSSYSSNTISNYHHHHHHPHQQHPGASASMGMNQSMTIDTRHPHHHYHNHQYYNHPHYHVTSSSGVSQQYTNSLERSGHRSKVSQVDYYGNMYNGPSTSNMPMKPDQHQISSSSSSSTTTKTFCPHASSSSYTLQSHSNYPHHHHHRTHSTSDMIQVIENDDDDDDEDEVRDHFNASMNSGTANNVTTTTATVTTTPPQIFTTNVYTISNPTMVECITIGPASSKTSNSNTNNNTTTIHNNNNNNGINIGHSPYVSKRNNSSANTTTTMLINNQQQHYHSNNSNTNGNGNHQQTANNNNNNNNNTNNRTSRQSSNDSDIVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IET7</accession>
    <name>A0A922IET7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IET7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="97" mass="11233" checksum="438996A7EF54ABA7" modified="2023-02-22" version="1">MDRLANLKQQQTSSTSKINLFDGFGPKINCTVVIINDIKTLKDNGIRYKNQKIFPQRMSSIDDEVIVVIKLYNRTLWQEISQNYGENLKIKMNINAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IHC0</accession>
    <name>A0A922IHC0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="12">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MAT1A_1</name>
        <name evidence="19" type="ORF">DERF_003736</name>
        <name evidence="18" type="ORF">HUG17_5619</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="12">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="12"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IHC0"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000011">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="15">
        <location>
            <begin position="34"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="16">
        <location>
            <begin position="146"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="17">
        <location>
            <begin position="268"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7642574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9529878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="433" mass="47758" checksum="CE7E74A895940D3B" modified="2023-02-22" version="1">MSSMQEDSIYLNGDSSPDQINGNGDGHDPHEDSFLFASESVGEGHPDKMCDQISDAILDAYLTVDPNAKVAAEVATKSNLICVFGEITSSATINIEDVVRNTVKRIGYDSIDKGFDYRTCEIKMALENQSPEIASGVHVNRREEELGAGDQGLMFGYATDETEEFMPLTVVLSHNLNKKIAELRRNDVFPWARADSKTQVTCEYRFHNGSAVPIRVHTVVVSIQHSESITLIELRKEILEKVIKVVIPSNYLDDETIYHINPCGNFIIGGPASDAGLTGRKIIVDTYGGWGGHGGGAFSGKDPTKVDRSAAYAARWVAKSLVHAGLCRRCLVQVSYAIGIAQPLSITVFSFGTSRLTQKQLVQVVNENFDLRPGIIIRDLKLNRPIYEQTSCYGHFGRKEFPWECPKQLNLKSVKSSLNGNYPTNGNGNYNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KX09</accession>
    <name>A0A922KX09_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KX09"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="448" mass="54007" checksum="B437F00B3B19B198" modified="2023-02-22" version="1">MEMIKHFNRKNSSLITNIFYHSIGLLFFIMKFGQNKNSNTQTDLKISSQKTWLEWIHQIHHLDHLHPLIRLFIPYKSLQYFNDYYNYVRRIHHHRQQTNHQLYRFYYTIIIVHMAKLIHLTFLYLSRNHTDDMIKIIQGDISIIFQVNQFEQLLTIFPMILGLKAFWQLFYSTISYWKSHDHPERRYFIPPYKIYDYSAVNCIKWTGWSCANVLHLFFPILREYNNFNSFIDNYRIYCGTFIMIVCQGLMILLFIWIRLWQARNYLRLISLKSNIDHIQRSLKKFIKFQRQTISLIILVDRFYSKSFLLIMLISLPINIFAIIELICGNAMKFIIIILALHEWLIIFALHLLIATINERIKLSNKQMFGILARTTTTTITKRIVTNHQPNSFYFNWNCNCYLQTMYTQIRPYGFTYGSISLVSMQSFVLLTVGYIQGILFFYKLFNHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KXR6</accession>
    <name>A0A922KXR6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KXR6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="78" mass="8309" checksum="12EFC78C154C4EAD" modified="2023-02-22" version="1">MNGCSSGDSNTNVANRMNQTIPIIPNQSNSPTILSTSVDPGHFSSEINENSSTIIVSFFVVDVLTIETMAILSTTLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZI2</accession>
    <name>A0A922KZI2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome non-ATPase regulatory subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PSMD8</name>
        <name evidence="8" type="ORF">DERF_011457</name>
        <name evidence="7" type="ORF">HUG17_10602</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD8, a base containing 6 ATPases and few additional components. Interacts with DDI2. Interacts with TASOR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000006">
        <property type="protein sequence ID" value="KAH7640122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZI2"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="84"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00078986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7640122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9506740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="276" mass="32250" checksum="74F688B446ADE19A" modified="2023-02-22" version="1">MNKKPAPALNDTVALSKMLQSEWERSNHNMEKIESYLSKLKLYLTKLQFLPIELGEQISKQELVVARDILEIGAFFSIETKNIPAFERYMAQLKCYYFDYSTDLTESTFKYQLLGLNLLCLLSQNRVSEFHTELELLPMKEIQNNVYIRHPVSLEQYLMEGSYNKIFLSKGNVPSKYYTFFIDILLDTIREDIAGCIEMAYDRISESEALRLLFFDAKDKAGLVQYAQRRRWTLNQKREYTFGHGKNRNDGAVAKIPAQKIAVQMLEYARELEMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZU1</accession>
    <name>A0A922KZU1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_012170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZU1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019311">
        <property type="entry name" value="Fy-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16525:SF0">
        <property type="entry name" value="PROTEIN C12ORF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10154">
        <property type="entry name" value="Fy-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9501316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="616" mass="71599" checksum="5A449E1F2FE9D5BD" modified="2023-02-22" version="1">MENKDKVEQVPQKTCPEEPIQQEQPKEKNNKVPLLLIPTGNTPILKKKNFKVDSNFTIGQLKVLIKKFLNLESNEALFVYVNQIFAPSLEQTVQNLFDCFGCDGKLILYYSKAQAWEFQFKYQTSSDESVFQHSIRLPLDTHVTPREYGFLLMKQYNVPEYFEDDLMEKLQSFIDENIDKIQCNHIEHVLQNQQKLASKSLQFIEKLKICPTLPDSKLQNQNLQKPKDNISEEKFYLMYHKIIHSGKLTQQLIQLENHNSDVIRSLINQKEEFLRGLSQEQNKKIEDILLSGKYSEKEINMLTKRNISLAEKTRNEWLEKIRNVRCDQKREFYTWIKNTYEDLMKDSCKHAKSNSLDLKHDSTSNVLTEDKENSFSDFVDISDELEMQESYTINLGSQLKTTHNLRLIAANMLKFCSNVSTPHRIQTAMSLYSNSLSAVVLLADESLTTDLNRLKPVNEQKQKNGQNYRLKTGDVYITRHSNLSEAHVVFHIVTDDSIRHSEINSRHPVILGLRNILKIAYIYDIANIYLPLLLLDQMYEDITIQWCLKRAELILKCVKGFMIEMSSLLSISDSENKTIQFVVPKGISQELFTALSSIFPTVFRLSNPLFLTKNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L278</accession>
    <name>A0A922L278_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L278"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="1">
        <location>
            <begin position="38"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="459" mass="52587" checksum="9E9E402C30EDB0B1" modified="2023-02-22" version="1">MDTAIYIINVWIKGDGISSYEKFFGRKPSYDHLKTYGCVAYYHQPKHLRNKLEETSVKMMFLGYTNSTVNYRLLDPVNLTVITTNDVRFDESELYYTESSDNRFIVQTTDSSSDVESIDLEERVHDIQSSNLFGYSCINSSIIPTSYENALKMSDVEQWKEAIQKEVDQLQKYGVFEKIPITDLGQVHDYLGLSITETAKSFDLCQSAYIRKLLKEFNMEDCKVTNEPMSNLYQQNNEEEVNESLPVQKLLGSLIYIANRTRPDICLAVNWLSRFIKKPTNSLWLAAKQILRFLVGTIEQKLVFGSLDSQIELFTDASFGQGETRHSTSGLLIRSGESILFWRSVKQNKISASSCESESKAILDGYNSVVFIKEILEFIGFKVRVKVKCDNKSANHIFSGSTMKKSKHFNLEIKKIVEIFSEDPDFEIEYVDTNSQLADILTKPLTKVSFERITNKIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2T0</accession>
    <name>A0A922L2T0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DERF_009677</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2T0"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Bumetanide-sensitive na-k-cl cotransport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
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    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002443">
        <property type="entry name" value="SLC12A1/SLC12A2"/>
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    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
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        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
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        <property type="entry name" value="SLC12"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR01207">
        <property type="entry name" value="NAKCLTRNSPRT"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="623"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="17">
        <location>
            <begin position="182"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="18">
        <location>
            <begin position="820"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="814"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023053"/>
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            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9511206.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1052" mass="118614" checksum="8D6B63DF993EA6DF" modified="2023-02-22" version="1">MNRDKESPVNNDDEDHHHHHENESIPLFKNNDGNVKIIKNESINEPIKNAKHLSVHYQTDQDNNKDPIEQQPQTPDQQIDDGNGTLRSNSAHGTIHYDTKNLKSFKNYTREALPRMEFYRNLMSIVRFHGHGHSNRPTLDELHGNQTSISLDNPNEKGMNVPTSPMDSIDPSKVIKFGWIKGVLVRNMLNIWGVILFLRLSWVGGQTGLIYGILIILLASLCTTLTAMSMSAICTNGEVKGGGTYYMISRSLGPEFGGAIGIIFSLANAVAVAMYTVGFAETLRDVLWPENDSINMIRIISCITVILLLAIVFIGTAWEAKAQVFLLIILVTAMFDFIAGFILGPVNDQQIARGYFGWSTEILHQNMMPDYRDGHNFFSVFAVYFPAATGILAGANISGDLKDPSKAIPKGTFLAIAITTIVYIAFHVIMTATVVRDANGLLELIISDNQTGQLLPNVFEAIQDCSRTNCQYGLLNFYQIVEMMSMFGPIIYAGIFAAALSSALASLVSAPKVFQALCNDRLFPYISFFGKGYGPNNEPRPGYLLAFAIALCCCLLGELNLIAPIISNFFLAAYTLINFSCFHASFSRSPGFRPSFRYYNQWLSLATAILMTLVMFITSWSTALLTFLIILVLYMWILYRKPDVNWGSSTQAQTYRSALTSVHRLNAVPEHVKNYRPQILFLSGHPKHRPDHVDLAHLIIKNSGLLICGNIVTDPISARTQIKLQNDSNQWLTKQNIKAFVDIIQEDDFHKGARALIQLTGIGKLRPNIIMLGFKTDWNNCESKCLLDYFNTIHTIFDHHLSVVIFRHNQQIQQQNGTDNNKTNADDPITDDMNSSSTNVDSENPKLESEILEPKTERLFLTKQSKGVCIDVWWLYDDGGLTLLLPYLIRSNPQWNGCKLRVFALANKQSELDIEQRNMAALLSKFRIDFSSVTLITDILKPPKEESKAEFQNLIAKYLQRDDEQQENEGNFPITQDDLEQFKDKSNRNIRLRELLLQHSKDSRLIVMTLPMPRKDTCPPSLYMAWLDTLTRDMPPIMLMRGNQTNVLTFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3G3</accession>
    <name>A0A922L3G3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_010364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3G3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF116">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG5065-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="7">
        <location>
            <begin position="38"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="6">
        <location>
            <begin position="381"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9511941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="514" mass="58880" checksum="E286B70D02ED3978" modified="2023-02-22" version="1">MMQSSSMTIDQQHNNNDNNGNRRRRYRFENFIMENPFSGFIGKVLIEKLLNSCPDIERIYLLIRSSRDGKSPQQRLEEEIIKSKVFTLRNKTYDFTKLVAICGDMTKPRLGLSDIDYQTLTDNVSIVFHSAATVRFHGPLKKFVNQNVLGTESVMKLSRDMKKLKIVVYVSTAYANCNLIDVEEKVYPLVDDIDSLINKIINEDSDETPGVGHPSLMGRPNSYTISKAIAECLVDAKYSDLPVVICRPSIVSHAYREPAEGWCDSLNGVAGALLLGGLGIARTMEMRCDYISDIIPVDFVANSLIVVGYHSCMYPEQRSKVVHITSGHKNPISWAQILNYSRMAAVKTPSVKMVRPIAQNPISAGTFVGRMNHRLTMFFSHILFAYIFDLILFICRQKRVMVDVTNKMHRVLEVLEHFTNHQWFFRNDNYSKIFQSLSDDEKQRYQSNVTAIDWTNYCNALWMGSRRYLINEDDSTCKDGIRRHKILKLTYGLLNFFIYTIILITFGYIIASVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3K1</accession>
    <name>A0A922L3K1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Death domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3K1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="399"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9510460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="515" mass="59199" checksum="8182DC3D1D7D9CD9" modified="2023-02-22" version="1">MSIRCNHITTIPTSTTSTSNGSIQSVPLISDDVEHLTIEIRQALENMLGKDTEIWRLLARELGYDEKHIVQFETKKQKIKCEEKYQRLIIMKKEIKELVDKFENNNIENQLFNKSPSPIIELNTEIGPQPQSLTQNPIVPSQENMETPSMIRPAIMYGYQIWGDKLIVKTKNKLNSIQHHILLKSIYAYPTVSCNIIQDKAIRKIVMALRKKHSINNYFNHVNDNFKRIMMMNIHFDFGHHTKLLPPPPPPPPPYNANNNILTSSIQTCPQHQYSYNIPTWLSSQTTDISPYQSPLPHYHHHNSVMPLFSALNQKESTQRKFHNHNNNNNRSTPLTTTNHYGQKTYNELLIGSNSPTSTTSTSNGSIQSVPLISDDVEHLTIEIRQALENMLGIDTEIWRLLARELGYDEKHIVQFESKATTITNGLKMIDTFKAIRLLLLDWSSQMTTSPDDHHQQQQQSTETEIAGPPSLATLSNALIRIGRVDCARVVVRQNYHQQQRQRQQQQNHTSTSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4B6</accession>
    <name>A0A922L4B6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4B6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="164" mass="18415" checksum="68A29BCCCD4498AF" modified="2023-02-22" version="1">MRKISDNDNDSNHSSMMTMATILPLNNNNQDYFVRNHQNHPRIITNENIQQQQQQQNIHHQSLVPVPTTTTTTPITTTITTTNHQSLDEETMSFQNKIEIHNTIKNKSASKNEINIPIGNMDTSSSSSSLSSTCDPIIYRDIQWPPTPSGTIAIRSCPHDTSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4V6</accession>
    <name>A0A922L4V6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4V6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="114" mass="13367" checksum="852683BFEB990322" modified="2023-02-22" version="1">MFGCDVLCIDEASHFLRDLSGSRRDRVQTECGQYPTCFRCLVVDNLRTNVEVNRCNQGWLNEWKLLVEHSRWLDAQEVSLLQIIDHFEGPYLEEVELGCPIRSLCEWFHVVHCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4X2</accession>
    <name>A0A922L4X2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Pgr15l_3</name>
        <name evidence="12" type="ORF">DERF_007869</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4X2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235:SF29">
        <property type="entry name" value="GH23382P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24235">
        <property type="entry name" value="NEUROPEPTIDE Y RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="233"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="639"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9517180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="715" mass="81164" checksum="AEF124CE09553ECC" modified="2023-02-22" version="1">MMIGFGEDLDVDIDDINITSITDLNTLPPPLSSSSSSSSLYNYYRYRSNIGIGGGSSSSGSTSNSIDTSTINLNQSKSMNISLIDSLQNFTNNLSSTIMYPFMTPTSYTTNISSSSSSSSLSSPSMMINTTMAKMVTTTQDDDNNGIFIPLSSSISYQHQQQHHHHHHQQQQQQDESISSSIALTPSMNLTFTSGTIDELQTMVDESVFSLWTFEYISIIIFYSLIILVGLTGNLLVCRVAFGTRQMRTTTNLLIASLACSDIVMIVFNIPFNVVRMLPISWPFWSALCILAPLIQYSCVYVSTFTMTLIALHRLWMVRQRSATNTEKNSWKKVALMVMGIWLIAITLSIPHASFNRVKEKRYYGRLLYRCSIQYPNVSFNFPLLMTVEVLITQYLLPLSITLIVYVKIGIVIARQGALICKLSDERKRRQSEAKRRRIFMLALAVATFATCWAPINLYILLVDMRSVKFNQVAFIMCHWFAMSSVCYNPIIYCWLNEKFRNGALQSLRTILEFAHIHFMAKNSNLTINNNDNNNMMMNANNKNNSNQIDLISQQRRQQSSILQHGQQQQQPITQINNNNNSISTMVVNIDDSNDDDVVIDDDDDGKNKKNVRSNGNVINMMMTTPTATTTTTRDRILHDKNNNNNNNEKFHNNDDDDDVNESFVDHDSKQTIITINNVNNNNNMAIVKKEPKNLHHFHQHQDVHLNNNNNEYQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5T0</accession>
    <name>A0A922L5T0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RWD domain-containing protein 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RWDD2A</name>
        <name evidence="2" type="ORF">DERF_007229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5T0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038021">
        <property type="entry name" value="UCP038021_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="1">
        <location>
            <begin position="160"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="270" mass="31729" checksum="CF676E24FF54C33D" modified="2023-02-22" version="1">MEQQQQQNSDDPRIAELIIISSMYPTQLQCVDDEIQRSIDEQNFHRFNHSITALFNVDTMLEIHLIMPVEYPNDDPNCLQIYCRITDTSLLNDHKNLQKQLNERVKNEIIDSGSLINVIPKIIEIWTEMKSSKCDSNHSNAEKDDDDDKIDNNSCINRCWIYSHHIYSSIKRKSIIDLCRKHNLNGFMLIGKPGFICVEGSDNDCDQFWTTIRSWNWQRIIMIDVEKMSKSQTQHLTFDSFVEHVDRSTVFRILEQKKCDEIIKNFLGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5V5</accession>
    <name>A0A922L5V5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5V5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="127" mass="14288" checksum="488ABEC9946DE2EE" modified="2023-02-22" version="1">MTEVSLSSASTTRRTIAAVSTTTTRAGKQRFKFVQIVQRQSASTAAAVTNTITYPSKKKKTVYIYALIRGAIKLIKPRLSVKNTFHLYMNTKYNTLYILMIQYQNFDTVAPPLLPVMGICVWLTMNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L643</accession>
    <name>A0A922L643_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L643"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="90" mass="10772" checksum="F2CB84EBFD97819B" modified="2023-02-22" version="1">MFHNNNNNNNAHHHNVYRSRYIRAQFFFVYFIASLIGTIYSVRTFESLLMLKLTMMILWLCIVETFYGFTSSKGSKSIVKKYPNHEFEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L682</accession>
    <name>A0A922L682_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane emp24 domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TMED2_1</name>
        <name evidence="13" type="ORF">DERF_004453</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L682"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="12">
        <location>
            <begin position="37"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9520763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="219" mass="24740" checksum="C796B2E42B00E401" modified="2023-02-22" version="1">MKNLTVKSKSIFIVAIILAICLNSVHSYFLVIDAHGEECFFERVASGTKMGLTFEVVEGGFLDLDLSIVGPDHKEIHHEERVSSGKYTFAAHMDGDYQYCFGNKMSSMTPKVVMFSMDVEEKAKHENKDGIGGAHHDSSSGSNDHNKLEEMVKDLTSGLSSVKHEQEYMTVRDRIHRQINDSTNSRVLLWACFEALLLVAITLGQVFYLKRFFEVRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6C8</accession>
    <name>A0A922L6C8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6C8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="95" mass="10692" checksum="1ED0186BF1B12D82" modified="2023-02-22" version="1">MLLERTIDLFLETEIELPPEILESSILLKVVVDDVTSFRMDFSGTLFTIFTDAFAFGCVLKSRPGHQICSCKINSTTKLTPVLQMQTIDKCGLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6Q8</accession>
    <name>A0A922L6Q8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6Q8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="114" mass="13284" checksum="17980F86311C1761" modified="2023-02-22" version="1">MLFILYSEIFPSFFKSLDLSSSSSWYGSRYLQMFSIAVIHIWSLSKIIISISIFHFVSRICSTTKKNEKIVILIQFGQPTKKKIALTVCKFIKNIVCKDVCHIRMNLLKHFNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6T5</accession>
    <name>A0A922L6T5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6T5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009991">
        <property type="entry name" value="DCTN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28360">
        <property type="entry name" value="DYNACTIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28360:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07426">
        <property type="entry name" value="Dynactin_p22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="228" mass="26943" checksum="EADC9B2CF521EC33" modified="2023-02-22" version="1">MVCYFFSIFMILINKIVRNFFQDKSIDLLSLRLADIEQRLYGFNPDFSTKISAEHQNAIHAVAPHNVNLIGMIAEIEAKLKSLTMGKDRFNQCYNELLRLQKWLREDDQMDLLIRTFGSHASVVKFEQVLAFEDEIRSDFERIGQIERLKPTLDQTHLSRMAELEPKLVRLKLQLLAAQQQSKELDHETKELIERFKIWYGDLMGNFQRIHENLCQLERQHDATKYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7F1</accession>
    <name>A0A922L7F1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein wntless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">DERF_008899</name>
        <name evidence="22" type="ORF">HUG17_4752</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Derf</strain>
            <tissue evidence="23">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">JKM2019</strain>
            <tissue evidence="22">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="22" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="23" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Derf</strain>
            <tissue evidence="23">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">A segment polarity gene required for wingless (wg)-dependent patterning processes, acting in both wg-sending cells and wg-target cells. In non-neuronal cells wls directs wg secretion. The wls traffic loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, and involves clathrin-mediated endocytosis and the retromer complex (a conserved protein complex consisting of Vps35 and Vps26). In neuronal cells (the larval motorneuron NMJ), the wg signal moves across the synapse via the release of wls-containing exosome-like vesicles. Postsynaptic wls is required for the trafficking of fz2 through the fz2-interacting protein Grip.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with wg; in the Golgi. Interacts with Vps35, a component of the retromer complex; wls stability is regulated by Vps35.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Presynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the wntless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7F1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061355">
        <property type="term" value="P:Wnt protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053936">
        <property type="entry name" value="WLS_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009551">
        <property type="entry name" value="Wntless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449:SF2">
        <property type="entry name" value="PROTEIN WNTLESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21883">
        <property type="entry name" value="WLS_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="422"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless GOLD" evidence="21">
        <location>
            <begin position="72"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="20">
        <location>
            <begin position="228"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAH7641707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH9518309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="563" mass="65272" checksum="8657222FD8BCB1C4" modified="2023-02-22" version="1">MPGTILENLSNRKLIVVLSIIFLIQTISFLIGAFISPAPSSPEQYIAIQCIPENPNEFSIPRDIGGRQKNCRQPESHEQNNITFAFQMPLPRGGIQLDYSRWMQNLLTLIVPDVLYDTRLSGGDDHSDQDQHINATVIMNVRLAVKNIGDKEWKQYYQRSNLKRTVTCHIEAHKRKQGINYDCDLIQLFELQSLYYDFYLINLQFIANEKSEHFGFLNNLSLVAIHQNGGFTKIWLSLKSVFFIITLMTFLWYLNRIQQLKRDTNLLEKCLILLGFGITQLNVPVEFLNLVMDVEFMSFLCDIRQGIFHCSLLIFWIIFIGEHLLDDVSRVGLSSYYKQLAIILIAYISLFVFESSERGIQVIDPFYSIWEVDSNFAMIFITITVLAAISYFFFLTYHLWLAFRNISTKQQSLPSMPTARRLIYQGVIFRFKFLLIATFVCATCTIIAYIMGQVSEDQWYWDDQRSFLNSLQWSSAMFTTVFALWNCYVMTLLILYAPSHKGMDSSDTDEMSVEFTRLTDNDLNDGQARINYSGTSGQRRNPNQKPQYEMSLLQELATKRNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7N6</accession>
    <name>A0A922L7N6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7N6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8562" checksum="E3819D3C61773B0F" modified="2023-02-22" version="1">MEQQTHGYNTGYFKLHNYFSCDKNLTSIMFGSKLFYDNDDDDDKRKLLILPQFNSKLSIYVFVVRNNNNNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L843</accession>
    <name>A0A922L843_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L843"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47589" checksum="D4318BAFDE9F585C" modified="2023-02-22" version="1">MMAYRGRTLPPAPPPPPPSSSQSRLSKISSNRYSQQYYSTTDSTSSSDNNNLLSNHNQNSIRSRSISNISRLSNSNHSTDSAPSRSSSISNSSANMDNDSNGTTPPHSLSPTTTSRLLDEFEQSKIEMFYRSHRTFVYVGQCLVTLLFTETELVDGGRQSRPKSKDWKQICHGVPVLLFNRGDTRSRDKRQIQICIAEHGTGFQLWTDIIDNLSNYHALKPTFHTMYLSMDHRKMAGFQFENQFAALEFFRQIEIITANPLNISLTGPKAGKKSGEKFRIFRKQRSKSVGRSNDIHHHHHHNVSNESSPFYDLHDQSKNNHSKNKRPPGKTDISTPCLFQHVTSVNLHNFNQFDSTITGQNGDENSNATTESDFNQKFENYSTRIRSDYSTPFPYHHHHHHHHHHHNHRSTTTSSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8I0</accession>
    <name>A0A922L8I0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_000280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8I0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="591"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="631"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="880"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9526178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="994" mass="110374" checksum="16BB101D02D6FB03" modified="2023-02-22" version="1">MSNNKEQLCNEDETIKYASDSCSSDDSSNSEEFYDAPEVIPLELVNDNDISKQIQSNNNTNHPVSSLMADSGIYSMNSSHVEPSQSPAIMETIENKIDSINSSDRIKNESLIVEPFSILAPLPPPRSRKKKNFIRKTKASDELGETNTGNHSSAESQSVTNSIESATHGFQIHGQNLSSILDDIASIKGDLSITECDKQSAFHDDIMANKATEKKLSKQDFIFSKEQLEEISRNLITKDNNLPSPSSSGSINAPEPECLMTESTQSSDSNQVVMMNTANNEEIQHIQSDDIMPKCLNPLSLHLMKLTNTEMSNTSMEKETSSTSLADSTFKSVTSLISSTLNDMKIEKKGTLDKKNKKKLLDSIENDDEFDINDDDDEYDEYDKNYSDYKDGKLKSKIRDLKRIGSGLIKGVKGVKATSAKRRSTFHVDPNEGDIIPPAPPRYKLKVNHKRGSADFEGLKLIQEINDCKGAIWCMKFSNCSQLLAAAGQDHLLRVYCSQKSWKYFTQLRNKASGQHVSPNSTRERSSNGDSFGRSQTQKSSSYSRNGSLNTCDSHNNSSSSSNSSALAKEFYKDEDNTLSEEGPLLLFTIYRGHTADVLDLAWSKNHFLLSSSMDKTVRLWHITQIECLCTFRHIDFVTTIQFHPRDDRYFLSGSLDGKLRLWNIPDKRVTLWNEVPSLSSQRGSGGINNASDSDMNPSHGLITASSFVQNGKFAVIGTYDGRIIFYTTDQLKYFTQIHVNSKNSIGSSAGQTGAGTRRFRTNKVAGIESIDANNKILVTTNDSRLRLYDLRDLSLTCKYKGCINQSSQIKASVSHDHKYIICGSENNSFYLWRTQDNSTIGQRRDRNKQYECIRLLNIPLQQTIPSAVFPATTTTTTTELSTSSGVKNDSNNSTYTIPNQSETTKEGNTIINKVNNVESSSMAKSKESFDLNIQQPPSIASSSTSAPMAKSIAATKIVTSAIFASVPGQIEEKARYIIAAADFNGYIRIFSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8K0</accession>
    <name>A0A922L8K0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein g subunit beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GBETA1</name>
        <name evidence="8" type="ORF">DERF_005316</name>
        <name evidence="7" type="ORF">HUG17_3640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8K0"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7639607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9521682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="340" mass="37328" checksum="F4268099905A9366" modified="2023-02-22" version="1">MNELDSLRQEAETLKNAIRDARKAACDTSLVQANTNMEPVGRIQMRTRRTLRGHLAKIYAMHWGSDSRYLVSASQDGKLIVWDAYTTNKVHAIPLRSSWVMTCAYAPSGSYVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIVTSSGDMTCALWDIETGQQCTSFTGHTGDVMSLSLAPDMRTFVSGACDASAKLWDIRDGMCKQTFPGHESDINAVTFFPNGYAFATGSDDATCRLFDIRADQELAMYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDSMKAERAGVLAGHDNRVSCLGVTEDGMAVATGSWDSFLKIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L919</accession>
    <name>A0A922L919_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L919"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9503" checksum="8FE37AB33EA84D5B" modified="2023-02-22" version="1">MFNTFTKVKVFFHILFGFYLRGKNPHAKTNGIILMKRKKKPKPTESSSSSSLSSSENLKIYHHQKQIRVYNNNNNNNKCTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L977</accession>
    <name>A0A922L977_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L977"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="153" mass="18901" checksum="6B768FC7706A1EE8" modified="2023-02-22" version="1">MYRNNSNNKMITTTTTTTKQMYSNEKAARKHNKENISQIYQNFHKPKFFNNKTKLYYQQQLFLQVIQTFFEFFFLLNNDSDSDYIYILFFSLYDHYLIHFGNIVIFTTLPAGFFFILKMNRFFCRRRRRRRCCCALLKWAKIKTIRREIREKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9W7</accession>
    <name>A0A922L9W7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_001700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9W7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037388610" description="Integrase catalytic domain-containing protein" evidence="11">
        <location>
            <begin position="22"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9527693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="68304" checksum="C652C5BCCE0E86B3" modified="2023-02-22" version="1">MITNVARRIIIIAFFNFLSETEYLFQGNSCYESTFSHNFGRIISTHELGPTRNNASRLPLMPSIGLPSKDICTSVNVASSSRCVVTTALLPRPKFDRLADRLASRDKVTMKDIVNAFVEEDEKAKADLLSNKSVDISMPQTAKMATTTKKSQRKSFPKQTNLKCSTNASSSSSSNTENSQPSRRMAKSAVLKPSSSEFTNIDSNSWVLNCSSPTHGTVDESNLINVRSEHNVFTDPDGRPIASNKIGDVIFHRDSKHQLILKNVAVGKFQCNLISVQQLLADGFHVNFDTDSTNPAAHIRKDDVSITAYQNSNGLWIFHQRPKLMSFSLRQKRLDHCGKSTSQQVNHRFPHVQGSNDRCDNHVSAPSSKQRPKSYVNDQSFNHLHIELWECPYPTCGDYQLGMLIVDHHSRFCFSIPLKSKSDATNALIRFIRRRQARYRKSIRQISTVSGDPFDNGVMLCHAVCTMLESTNTPHHLWVETMGAAIYLNNISVKDGDTSPYELFFGRSPSQYHYRSSGCVVNHQQPSSKCLSNRIYRNRSVDHLPSSSSSSSSSTFIRSVVSDSELNRIDSFNRIDRHDLGNSEWITVNRKSRKKQSSYYHSRKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAY5</accession>
    <name>A0A922LAY5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sphingomyelin synthase- protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SAMD8</name>
        <name evidence="12" type="ORF">DERF_001223</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAY5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047493">
        <property type="term" value="F:ceramide cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033188">
        <property type="term" value="F:sphingomyelin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290:SF25">
        <property type="entry name" value="SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="SPHINGOMYELIN SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="585"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="685"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="734"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="11">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="246"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="459"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="837"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="365"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="843"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="866"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="877"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9527187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="889" mass="102527" checksum="37BD5010BEB8588F" modified="2023-02-22" version="1">MSKSSTVNSIISYDVNVDDDNSNSNNNNNNNDKTTITYENNDNNNDTILNLKPNCIPVNDQTSSSSSSSIAMTVNSHSINNNSAINTETHTWNNNNNNEHFNGSKNRSSSMIVIPKYHRSNENKSTIMNNNHHQNLLQQRKTSMTNSMIDDRNNCALTTTTTMMNPSFKKSTNGFIILDNKNVYDWTVHDVGHWLEQNDFSDYRQLFCDHHRIDGRIFGDIKRFSMAFDYLRSIYLSSNNSMEDFNKNHNHQNTKSTISSQSSSTSTTSSSSNRHSLVQPKFSNGSNKSISNQMQPPLKQYSIHSNDQRQQQIQNQMENNNENIQEMEITFNGHSGNDDDDDGEIERMRIYNDHEEQQQSNLTILSNCSSSSSSSPTASIGCSSSFTSSSISSKASNRSEDNDDDDDYADANESESTMLLNHGSIINNNQLKYRNNNHQIRIVPQLTTSNDLAQMIAISHPGQKQQPKSSTVKNRNSSHHHQPQSSSYQRNNYQNITNYSSTSDKKHRKHHRKNNHNHNHNHHHHHHHHHRREVRQESWKALIALIYFFSSTWVTAIVMVIVHDRVPDMDTYPPLPDLLLDNLPLIPWAFGMAETCGLILFIIWALILIFHKYRFILLRRMFSLFGSVFLIRCFTMVITSLSVPGRHLQCKARPYGTWTERLHQAYLIWQGGGMALQGVRTCGDYMFSGHTVVLTMLNFFVTEYTPPSLYLIHTMSWVLNLFGVFFILAAHEHYSIDVFIAFYISTRLFLYYHTLANNRALYQSDRHRTRIWFPLFSFFESGVSGIVPNEYEIPFRRQKDKLINYLSRKICQISWIRAIFDQDDYYYNDDDDDCDHDHHNDYEQSLSDWPSDQSDHNSDNNPLLISSSSTTTTTTTQPQLAQNSKLKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCI8</accession>
    <name>A0A922LCI8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_000564</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCI8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000023">
        <property type="entry name" value="Pyruvate kinase PKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="34"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="15">
        <location>
            <begin position="404"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9526480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="512" mass="55696" checksum="DE776D6837094429" modified="2023-02-22" version="1" fragment="single">MLPIMDYQTRAIQADCRLDNLCALDIDSKPMNFRQSGIVCTIGPATRDVSKLVELIKCGMTIARMNFSHGTHEYHLGTIQNVREAAKIVGQEMNIANFPIAIALDTKGPEIRTGLLEGGPTAEIELVKGKTIKLTTNDEFKEKCSLENLYLDYKNIVKVVSKGSHVFVDDGLISLSVQEVGSDYLQCEIENGGMLGSKKGVNLPGALVDLPAVSEKDKQDLVFGCQNQVDMIFASFIRNGNGVKEIRQILKDNNCEYIKIISKVENHEGVKKIDDIIRESDGIMVARGDMGIEIPAQKVFLAQKMMIAKCNIAGKPVICATQMLESMTKKPRPTRAEVSDVANAVLDGADCVMLSGETAKGDYPFNTVATMAAIAVEAETAIHSKQLFVELCGKTPVPTDVATSLAISAVDASLKSNIVAIIVVTSTGRLAHLISKYRPRCPIIAIIGDERIARQAHLYRGIIPYIQSEQNPDDCSKDVQAGIQLGKQMGILRSNDSIIIVNGSTMRISQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCJ3</accession>
    <name>A0A922LCJ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metastasis suppressor protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MTSS1_2</name>
        <name evidence="3" type="ORF">DERF_003449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCJ3"/>
    <dbReference type="OrthoDB" id="10061327at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013606">
        <property type="entry name" value="I-BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030127">
        <property type="entry name" value="MTSS1/MTSS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708">
        <property type="entry name" value="ACTIN BUNDLING/MISSING IN METASTASIS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15708:SF4">
        <property type="entry name" value="FI21477P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08397">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51338">
        <property type="entry name" value="IMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMD" evidence="2">
        <location>
            <begin position="5"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9529572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="652" mass="74402" checksum="C546F5D86E5135FD" modified="2023-02-22" version="1">MMDTTTTTAVDRDGNALGGLFQNIIVDLRNGANNWDDLLLKANKFHLQLKSTISSSTAFLDAFQKIADMATTTRGGTKEIGSALTRLCLRNRSVEAKLKSLTSSLFDSFISPLQDRVDEWKKIISQIDKEHSKEIKRLKQFRKKHSSEMRVTSAFANNTFRMRKHLPRGKLKNDFPRIGSMYDVDKIIESVDCNNKEKYFMLEEVEKNYVRRALIEERIHYCLFFNLLRPVIEEEISMLQEIIHLEEILTTLTSLTNDPHKLPTSSENFLHSLQLNDSIVPILDSTYSEYGSHHHNHHSRKSSISSMDSLNTLSTDSVSFRNVKSLSQPNIIPGFRPKSIASQDSGFLSHDYNIPNIGRLVIYNGVNKINKDSTTADKDRICMLNGKSIRCLSTIESNDEKEIKEKVEYATSAPLYHSNTACPQPIYVNIHDACDRTRFTSEGSLTPTNHDINPIENSNYSKYYNTVNNSNNLQQQQQQQQQTNVESNHTCTKPKPIPPKPPMRHSSKLSTNTANNSLQFMTSETSKRSTLIFVKNTDNPDFPPPPPEAFIRPAEQCEKVADNLCCLYSVPSRNLVFCDNKECLQDYNRQTYRTPIYHSTSLNAFSMDSNQSSSSISQQEYHKNHDDNGCHDSQYDNHHHYQSSINLSSKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LD37</accession>
    <name>A0A922LD37_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA topoisomerase 2</fullName>
            <ecNumber evidence="6">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TOP2B_2</name>
        <name evidence="10" type="ORF">DERF_001782</name>
        <name evidence="9" type="ORF">HUG17_7599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="6"/>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LD37"/>
    <dbReference type="OrthoDB" id="6499733at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="29"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DNA topoisomerase type IIA subunit B" evidence="7">
        <location>
            <begin position="217"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7637393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9527785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="379" mass="43520" checksum="13D15788D12994C8" modified="2023-02-22" version="1">MDKQKVTKQMWVWDGDQEKMVYREITYAPLLYKIFDEILVNAADNKQRDESMDCIRIDIDVDRNEITIYNNGKGIPVFEHETEECYVPTLIFDTVLTPSNCYDDEEKKLVGGRNGFKAKHCNTFSTKFKVQTSSKEYQKLFSQIWKKNMTKIKDPKIGANAAEDFTRISFKPDLSQFKMNRLDKDIVALFSRRAYDIAGTTRDVNVYLNGKKLPISGFKDYVKLFVKDRQDEIGNDIKVVHQKVNDRWEIAATVSNNGFQQISFVNGIATTRGGKHVDHLTDQIVNKVAEVIKTENQVGINVEPSQIRNHLWVFVNCWIENPKFDSPKNETMTLKVERFGSTCSPSTNFVHKIYKVGIAEAVLSKELSKTGSIQQTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HJ26</accession>
    <name>A0A922HJ26_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HJ26"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="617" mass="71159" checksum="7C45A551BACF659B" modified="2023-02-22" version="1" fragment="single">MAETKLLVKMNILPFRRRPYNIIGPLIEYSFRSWKFLGIRLNYSYWQYYHQQIPLTFTVFQPAILITIIGLFTIIFYLARLQWPDYAFAINLEQSAHIMNIYRLDLAIIVMIVVNITVEILWIFSIHKVLNYDSGMNNLLAYYSFYGDIFEIFPQYRQYILRLIIISDYISIIMFTMLLLSIICWMSIFYIKIIAMYLQNQIGLFFMFYSMIMVIIELLRLIYLILAFTVPIKALIIMVEFFNIQFKQILFITKSLFNYRLNHHILIMMNMKKHWHRFHTKYVQLFDHTAKFNDDLKLILLAMETISKSTIICITIFYSRNVTDTVHGMMFIISLLTVFFIFNVIHSRFTHIPSYNKQCYRHLLPWNIHSSQRMMNFQSCRKNWLSFSYRYQIRTNLFIQTMNENPFGFTCGQIFFINKFNFVQIGFVCLALIATTNAYSNSGSGYSNYGSSSGSLSSYGGYGNVDGGGGGGGVGGGDQKSYGSSLDGMEQPQVIEVSPDQLPVQVHFRTASSRLNVQQSHGGQAMPQVEHASFQDDPQRIIHQIVKPVIQEVREIIQPYRRVTQEIRPVIEEVHTVVHKGENRRPGSGLQGKGAYGGGGGGGGGGQYAKSKAAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HJ53</accession>
    <name>A0A922HJ53_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HJ53"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="122" mass="14187" checksum="92C701748BE9421E" modified="2023-02-22" version="1">MFPEIGISLFNNNNNIKKSYRSSSTSFKVIIENISSKLGSRLANCGNTLELRVLTQLHHENIIINTLQDIYVSKWSTMAAKDKQARQEQDKNWFRQRKPNGNENEWGPMFKNKAHFSDMHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKA7</accession>
    <name>A0A922HKA7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_015936</name>
        <name evidence="3" type="ORF">HUG17_3901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKA7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276910" evidence="2">
        <location>
            <begin position="26"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7639868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9491205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="159" mass="17817" checksum="09B1BE56FDFEB117" modified="2023-02-22" version="1">MRWFQLLLATVVIVAIIYVNQQVEGKKLKKKELIALILLSKIPKKKLILPLPLPLPLPIPIFERTKKVIKKEPVVVKKVVKVPYEVPVKEPYPVPVPYKSSKYEPYDSYSAASGGDKYGGIEHGYPSRSRDYRGPGEYGGGYDGGDDGGAYNDDYDISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN02</accession>
    <name>A0A922HN02_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA (Cytosine(34)-C(5))-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NSUN2_2</name>
        <name evidence="4" type="ORF">DERF_013726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN02"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA cytosine-C(5)-methyltransferase NSUN2-like pre-PUA" evidence="2">
        <location>
            <begin position="50"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="RNA cytosine-C(5)-methyltransferase NSUN2-like PUA" evidence="3">
        <location>
            <begin position="160"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9497766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="315" mass="37278" checksum="68E5D8D0197E18ED" modified="2023-02-22" version="1">MIMKKRKKAEEEKGEQQTNEDGNNNKNEGDNKKNDQDKKQKYTGFREEPFYFIDENDEDWIALKSYFKFPMKFMANQLAHRCVQGKRRNIYYMTEKAADFIRMNKDMKIISGGVRVFNRTDVNRVCPYRITQEGISSIFPYFIANLDSYSPNNDEKSFTIVEVELNFFIELLKQQDIKIEQLDERCFIMYVRLRQDWQNEDSSSSRFILPMCVWRGKSLLRAYVAKNDRSHLLRLCGYEPISATITTTIADIKGENKRSLNDDHDDNGCDNNKEQFKNDHDDEDDDDDGCDNMEKTNENNHHQIHSCVEKRIRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNE9</accession>
    <name>A0A922HNE9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNE9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036849614" evidence="2">
        <location>
            <begin position="20"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9494302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="243" mass="24705" checksum="43E628F4CE704318" modified="2023-02-22" version="1">MFSKIIILCATLFVSQVTAYGGGGGGGGYSSSSGYSSSSRSGGYGGSTLGLGGSVGAAFGFGSTSGGVLASTAAASGPVQAAVRSRHVIEYVDIDLPQDEVVPQVIDVDAGHLPLILNFKSASSRIQVHQTHEGSEAGEIQETQSEDEPQLLRHNVVKPIIQEVREVITPYRRVVQEIRPVEEEVKTIVARGRGRTAGTGTTGTTGNAVGTTGRVGTGRGSYGGGTGAYGSSSFGSSASKSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNJ8</accession>
    <name>A0A922HNJ8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNJ8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="452" mass="51392" checksum="F369A9682C18D8BC" modified="2023-02-22" version="1">MKTIIASPLSSTMMKQQQQQQSPSPSSSSFVNDDYEYLMKDMDLITTCQEALEENSYNHHHHHHHQISSSSTLDYQQSELSLSSSSSCLKLNSLTNCQQQQQLHLQMSANNNHCDHHIQQQQQQSNDFTSMRSPSSAASSGLGLSLEEDFSLKYCQSDEEFSSLNSNTTNNNESMTINTTTSPTSYTAKALVAEFIEWLDYIENQLDSVCYCAKIAHDANESDDDDDENVDDESDDDFDESDHENDNYQKTHGDILNNNNNNNVQIDLDRTLIVNSDDSIDHHHHQRLLSNDKSQSDKTCCTQQQQQQQVIIDEDLVDDDEAEELMMSMKPISTTIHSMADQVINNNSQKQPNGDHHHHESLDSSKMKTIDEPSITITSTSSFQMSMSKTNLCLLPETIGADWSVILARHEVGVKNKNKNETFYFQLNMQAIIFVPEGFFWVRKKVDNVCYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ14</accession>
    <name>A0A922HQ14_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucose dehydrogenase-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_013701</name>
        <name evidence="5" type="ORF">HUG17_0956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ14"/>
    <dbReference type="OrthoDB" id="6487978at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF227">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7645418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9497740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="613" mass="68335" checksum="B3215AA61727BF6C" modified="2023-02-22" version="1">MATTASLTTQLLAISVISLQRQILHNNNVNRTELDTNNYDYIIVGSGSAGAVVANRLAAFNQSSLRILLLEAGGAQSVVSDMPGLTPWLVGSEMDWQYLTIPQTNIGQAFRDQRIRQPKGKVIGGTSTINWMLYNRGNRRSYDNWYTTYGCDGWDYNSILPYFIRSENNTSPKIVQENRGYHGTNGPMGVSPMAHPDPMLYVFQQQMNSFGIPTIDINGESQMGTMIYELTVNNGTRCSTGNSYIDPNPYANNLHIMANSFVTKILFEHNNQTNNITAIGVEFTSNGNNYTVMANHEVILSAGCIASPQILMLSGIGPRQHLESMNITVIADLPVGENFQDHVFIHHYYGVKNHSLLNEAVGPTVEQLYEYYINQTGPLTQLPNSITFFSTKTNDNPEWPNAVIDVNAYSVLRNLTETVSSYGINLQQWADFWTPYLGKQYLLVTSAIYRTYSRGTIRLATTNPFDQPLIDPRYLSDPRDLQALVDMTKILFYVTQTGEFPKYAEIFSQPIPGCQFCPDRPLYQCDSYVRCIIRQVADTALHPGGACRMGSTNRTDIVVDPRLRVIGVDRLRVIDSSIIPELANANTHAASVMIGERGVQFIIDELSSSASSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ45</accession>
    <name>A0A922HQ45_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Fascin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FSCN1_1</name>
        <name evidence="10" type="ORF">DERF_014890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ45"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055120">
        <property type="term" value="C:striated muscle dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23336">
        <property type="entry name" value="beta-trefoil_FSCN_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23337">
        <property type="entry name" value="beta-trefoil_FSCN_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000008">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022768">
        <property type="entry name" value="Fascin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06268">
        <property type="entry name" value="Fascin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fascin-like" evidence="8">
        <location>
            <begin position="89"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="8">
        <location>
            <begin position="294"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Fascin-like" evidence="8">
        <location>
            <begin position="357"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9494179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9494180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="611" mass="67075" checksum="6C0206A927D0201F" modified="2023-02-22" version="1">MWSGTVGLVNGQYKYLTAETFGHKINANGVALKKKQLWTIEPFPFGTSTGLSSSSTSSNGNGNHGGSINVRSPGMSPQSSIEEMDELENVAIKSHLNCYLAVDSYGNVTCDSQILHDGCRFTITICAMTQEGHDEDQISWAFRNISRGYFLGVSNDSGSIICNAKMPQSKAELWHVHLVPARGATMFGFKSVGRKRYAQIISSGNQKQIQIDSTNVWGPETLFQFKYFENGNYVLIPASTCIGSIKYISSDGICVDASNEKSSITNNNNNNNKLNGFANGNGLTNGSSSIVMPPKDCLFTIEYHGGFVAFRDKSGRYLAATGRQAVLRTRSTAVGKDELFVFEPAPLQVAFRATFNNKWISIKQGVDLSANQSEVTQHETFQIEYNDKYDCWYLSTKDGKYWSPGVASAVHVSQPNMSVKGRFRLSWNQDEGTCSLSLIDDDNDQLKPLCARKSGQLYTGGGESIKFHIKFMNRTNVCLRASNSSGFVGTKGQGSYKLESNKTMPDMFVIEYANADNPTISRDDVDAIDSSFNCCYLKLATSGKYLNVVDGQTLAADAPSMACAQQFHIELRTGTYIAIRAYDSNAYLNLTANGGIVFVNCPPEKATLWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HR75</accession>
    <name>A0A922HR75_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_010894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HR75"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="10359" checksum="DA9534E5F5CB5F19" modified="2023-02-22" version="1">MAKKKFNFKHQKQDQKPKKNLTTREFYLIFFSIAQILILMLNENHTIIITNDDDDDDDDGEDDNDAHHQHQHKMETNIWCVLKIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRE2</accession>
    <name>A0A922HRE2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA methyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TRMT1_1</name>
        <name evidence="2" type="ORF">DERF_010672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRE2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9505906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="100" mass="11829" checksum="C1E999F55B4A2453" modified="2023-02-22" version="1">MKTDAPNEFIWAMIQHLVKKSKESTSNNSKRQSHIQNILDKNFDYKINDTLIKEEPLSKSKNLLRYQWNPEQYWGPKSKPTTKRTNNNDEICTNKSMKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRK5</accession>
    <name>A0A922HRK5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Regulator of telomere elongation helicase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RTEL1</name>
        <name evidence="17" type="ORF">DERF_012148</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRK5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090657">
        <property type="term" value="P:telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057498">
        <property type="entry name" value="Rtel1_ARCH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23109">
        <property type="entry name" value="ARCH_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="6"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="757"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="848"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9501291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1007" mass="115978" checksum="CCD5D5128A9E8719" modified="2023-02-22" version="1">MDNEIEGITVIFPFKPYDIQIDYMRSVIKALNSRQNALLESPTGTGKTLSLLCSTLAWLENQKFKELDSQRIGNGAPKNIVFSDDLIISDDNGSKKEKNKNGKKTWKQDNPLRIIYSSRTHSQLNQASNELKNCYYQFCPSVTIGSRDQLCINPDVMKLENITAKNQICRHKVKYDLCSYHHNYKRIVSDLSFCGSKIYDIEDLIAFGNEHKSCPYYMSKELADYNTALTFMPYNYILDPSIRKTLKLNIKNTIIIFDEGHNIERVCEDSMSTELKSEMLALFLRSFDIVLKSLKELNDGTYEGINDKELSDLDIHDVAKVKLIISNLEQELDHLVNKDKHKKDAHDTQEIFNILNEVNLTYENIKLVSNTCEKISAVVMSSTPGFMSNQSIAALGAVCSFLEIVQPFTQIEEGESMSSKKREFVKNYKLYTEIDRENGYQKTWLTHSVPNNWTVYLWCMSPSVAIQSLKREGIYNLIITSGTLAPLESFEMEMGIPFHVKLQNSHVILSDQLSIQVVAKDPNGNLLCGSYDKRNDIKFTSGLGLTILEFAKKVPKGIFIFFSSYSLINQCIDVWKSSMGFNLWASLSSVKKIFVEPRNKREFNPMIEQFKYACDETPEGAIFMGVSRGKLSEGMDLGDDYCRAVMIISLPYPAKYDPKVVLKEQYLNENKCRLSGSQWYMLQMKRALNQSVGRVIRHKNDYGMIVLCDSRFQSLREGFSRWIIPFFKRENASLTFPQRIQQIDSFFKRSTNVHRDIENKNSKPLRLPPLPQSESKIEQSNHQDDNEIQAIFNNLASDYTKIKDKFPAKPKIEQQNDKLSIFDSFGEKQIIPKRKQYLTGEYYNKKIRPVSEENAPNENKTDDDSSSKQKRSISDRTSAYFEKLPIETPMESNKESIKSIKLPNIFDLNCADIIDIKKTILKSEQNIQAFESIIKQIINQPSKCRQLCETLKVYGKKQNTVYLAMRLNFILADIRNEKRNFILKDFSIIIPEKERKLFLQTCNVKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRM6</accession>
    <name>A0A922HRM6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRM6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="7825" checksum="77CCC882A5DB2236" modified="2023-02-22" version="1">MAMAAKITIMIEFKQKASFNRQSTAYIRLIGLAINTGYSNPPHFKLMTNSSAVALLLLVYISTNIYARNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRP6</accession>
    <name>A0A922HRP6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRP6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="111" mass="12826" checksum="EC6E2C7639EE55F2" modified="2023-02-22" version="1">MTPFCWYLVAIIFVFAAIAFYCYCYDDDHSLLLLPVVVAVAAAAVDDDNRNEIENKKRKLFEKVANSEKNTVAPKQKFSNFFGKFISELSEKKRKQRNQEAGFSELFRISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTG8</accession>
    <name>A0A922HTG8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTG8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="7970" checksum="796B85130BC52044" modified="2023-02-22" version="1">MANCAVSEISVLSSSAIENSLKLAILAFKLFSFQSVEQACSILTVHHEKILVVGATYSDDSDNGALRKDIRISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTT5</accession>
    <name>A0A922HTT5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTT5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7535" checksum="8091F92C1A90BD1D" modified="2023-02-22" version="1">MLLDYLHFDYEIYHSENVFVEYNDERNCGLAPRAPITGLLHAIFILGYRMNERTQMNPYEHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU74</accession>
    <name>A0A922HU74_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH domain-containing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BTBD7_2</name>
        <name evidence="11" type="ORF">DERF_009047</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU74"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000006">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9510525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="185" mass="21615" checksum="99ADCC461EC3A38E" modified="2023-02-22" version="1">MQTKLFATLDGVKNMFKVDDDLFLMGEELIRTVNEDLPNIDQLSMNKKEKFSVGSNKFERCRYWPSCMNGNKCDYHHPSIKCNMFPNCRFGDKCLYIHPMCKYDSVCSRKDCPFFHTFTANIKRCQLVMNPNKNKVTCKYFPKCAKPNCEFIHPKIVCKYGSACKTINCSYVHPDQNHIPHPHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU85</accession>
    <name>A0A922HU85_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GAG-pre-integrase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU85"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35204" checksum="D346F498BAD09AFB" modified="2023-02-22" version="1">MFHSSYPIQPNLSSSSSSILSSAATTTTTTATATGINHPLQFSSSTTCSTLSTSTISTISSINNNGHQSLLYNKQVEFELASDETVTSKKIGNIIIQPKPDCKLLLKDVAYGGFSSNLISVRKLTEDGFKIIFEDNIAYISKNDISFTAKTDENNLWIINSQPKNIVLNLWHKRLAHCGQNQIRSKILHPKPIIAHVGNKFKHNSIAIQSESLTKSMDELAISNCLNTEWMARINRSLSSPMISIDFSTIMVNLISKCKNQMVPSIKAILNYDFNANYILKSFLDNLKNNFNYGDIKFNDGAFHKSTCNISNCFTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUH6</accession>
    <name>A0A922HUH6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP:AMP phosphotransferase ak3, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AK3</name>
        <name evidence="7" type="ORF">DERF_009659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUH6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="6">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9511187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="219" mass="25516" checksum="7481508154C32068" modified="2023-02-22" version="1">MATKFFLKLVILGAPGSGKGTISNRMIRDFKLTYFAVGDCLRDHMKQQTEIGKEAKRYIEQGKLVPDSTINQLVINELREHGYPRNREQTLELWRQPDEFRPNAVINLIVPDDEIIERIKHRWVHLPSGRIYHMIYSPPKNPGVDDETGEPLTQRNDDKPDVIKARLHEFHKQNDEIVKLFREKKIVHDFEGRESDIIYPKIKTFLEQFIRSNTAASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUI1</accession>
    <name>A0A922HUI1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUI1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="118" mass="12753" checksum="E4207C47FC7816E8" modified="2023-02-22" version="1">MNGDLAGRHRPSLRKCTFSMATPRLILALCSNTYISSTDIFNLPTANACCLRSAITVTIVSAGNPSVIMAPFDVNPGHIIFAPDKTNVMAPSSTCINGHMNGSRLVMNMLCREIRIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUZ9</accession>
    <name>A0A922HUZ9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUZ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="188" mass="21243" checksum="578BD00410F65940" modified="2023-02-22" version="1">MYRLNKFGPPSNNLLYCRGSKKFAPYANFWLHCGTLDTTSDTMVTPHYTHKSTAEQSLLERPTGIRQHHLWTLNTTSDCQGNNETTTIINHVHHLPVPEEVYASWPVGNSNIVKQFFSAKPDGSTVDHNNILRQPICNRHQLHSLVDTRCDTGHFDHQAQQQQVALSLDATGIDTTTLVQHTQHGHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVY4</accession>
    <name>A0A922HVY4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVY4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="758" mass="87482" checksum="F1D8BAF4BAFEEB59" modified="2023-02-22" version="1">MKRSDESEKQHEMADQQMPSFSQSYHSESFLKKVQRRNEKFSTFVNKVLNRNAQVSDSESPAGSSAETIINKYHVEPGIIYDDDDLQKYASDSDDGDDEIVHQESTIEFENFSRRIEMNEMERIMIILLHQARFNTTNKEIEIFSKSLNNMAYRHCCTTGGEPIVSCSDWDTIITKVPNSFTPTIYKYFYSQCGDIIGPVNELNIPTTCCYSHESCRIIPSQKMKSDSSSFFCYIPLSKWLHHQIPLYYSKLRITRPKESKFFHDLSNSERYRQLVTSSSSCSIPTLTLTLTWDGVAYTNDGSQSMWPLCAYLNELPFQERINNPMLIALHSGSCKPSSDIVIKPLVDELVSLSTDPIIIDVDDAPARAVLLNSTQFNGYYGCQCCEIKGTYDNDFKSMLYIPNRKYDNSLSFDFKLRTNISWRSIASNNRGKSTMGIKGNCQLMKLSYVDMSIICPPEAMHSQYLGTVKSIINRWLDDDLATKRWYQVLPNEKKNELKTTKLNKTQLSIVDERLSSIKFPEGVLKAMPQLSQKRNLKSMDYELLLFYGFICFEGIVERGRCENFKQLAFILSKLSSRMISKMTDLRHVDSEIAKFFTSFDQVYSSKERFMWKINVHFLAHFLDMVKNYGPLPVQTAYFTENTMGLIAKRVKTGTNVTQQVMKKFLTYQSIISSCRNNTSHMSEMFLKSLYNYMPKLCPNNTPIKVFQEVYKPIGAENKLLGQGTFQSQKRIRIKEKIKLENIISWKKSSKTIEMKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWA2</accession>
    <name>A0A922HWA2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATPase AAA domain-containing protein 3-B</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Atpase family aaa domain-containing protein 3-b-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ATAD3B</name>
        <name evidence="13" type="ORF">DERF_010011</name>
        <name evidence="12" type="ORF">HUG17_0069</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
            <location evidence="2">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWA2"/>
    <dbReference type="OrthoDB" id="199596at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19512">
        <property type="entry name" value="RecA-like_ATAD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000470">
        <property type="entry name" value="ATPase family, AAA domain containing 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021911">
        <property type="entry name" value="ATAD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF0">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12037">
        <property type="entry name" value="ATAD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="360"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="586"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7644531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9511560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="612" mass="67733" checksum="58D1B181AB7B23E5" modified="2023-02-22" version="1">MSWLFGYSNPQRPPQPPGMPGSPDGGGGGVSGGSGGGSGSGGSGGLLNLSGSGGGSGKMNPYQFDSSALERAAKAAKELEQSRYAEAALDLARQQETTKQLELQKTMKEYEQAMASAQIEAKKQEQEHRRRMLAEESKQAQLKAQYEDQLARKRFEDQLAQQRAANDENLKRQEESVAKQEAIRKATLEKEMELRAAADAKRIEAEIRGQAQAERQNRDIRLEQLKAKAAEERTTLLEAIVTAGDVFGKGFRAFISDWERVSATAVGVTLMAAGIYTAKHGIGLAGRVLEARVGKPSLVRDTSRLNMIDGLQHPYKTVRRLALSRKPADALRGVILEPSLEERLRDIAIATKNTKKNGGLYRNVLFYGPPGTGKTLFAKRLAEHSGMDYAIMSGGDVAPMGRDGVTAIHKLFNWATTSRRGLLLFVDEADAFLRKRASETLSEHLRSALNAFLYRTGEQSNRFMLVLASNTPEQFDWAIHDRLDELISFNLPTLSERERLVRLYFDKFVLEPSVSRRSRLKLDVFDYDSTCTDIAKNIDGLSGREIAKLAVAWQASAYASENGILTHEMMMAKVNDAIEQHRRKMEWQAEEERIKRSYPPSSSSSSLSSPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX66</accession>
    <name>A0A922HX66_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPS24_2</name>
        <name evidence="7" type="ORF">DERF_009557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX66"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9511078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="158" mass="18538" checksum="B19FE393972742F8" modified="2023-02-22" version="1">MNCLKIDQIITCILDQIFFQKHFPNKMVETPCTIRTRKFMTNRLLYRKQMIVDVIHPGRATVSKQEIRDKLAKIYKTTSDVIFSFGNRTDFGGGRTTGFALIYDTLDYAKKFEPKHRLQRNGLYSREKTARKQRKERKNRMKKVRGTKKTKVGSGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYH9</accession>
    <name>A0A922HYH9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_010213</name>
        <name evidence="2" type="ORF">HUG17_0216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYH9"/>
    <dbReference type="OrthoDB" id="10051804at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276933" evidence="1">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7644678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="241" mass="27418" checksum="9661D55CC5E4CDA0" modified="2023-02-22" version="1">MKQSIAIVILLLIGTTLALKKTKDCDVEKPIRECLKNGLLRYSDGQKINQFPDSIEDLNRACEELKKSETCARNFIDTCTETSYEKRSLDSLLDGIQRVLKRLCRSQSKKEQLLQNVGCANSVVQDTKLCLKNYRMLVFAANKLNDKSKIMRILCCKSRKVAPCIGEAMKSKGNAVCSAKNIDYFREMHQNIKAEMTAVVCSDFERDQCENVEVPAITEAEYKDQNIFNPLRDLYKKVILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYR3</accession>
    <name>A0A922HYR3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYR3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9512126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="515" mass="53680" checksum="EA0E5F6F293720EA" modified="2023-02-22" version="1">MTAKSISNHHSSHLTNVHLHHHHHNQQHSTTPMMTNGLLPTALIGLNRNLSSSSSSTSSSSPFGGQQQQQISGGLQPPPVVTIPPPPPPSHTLLNPLLAFSHFADLQNAATWSQFAAAAASGGGGGGGGSNRSSSGVGGGGGGNGTFPHHHHHHHQQHHGNIGGGPAFPHPRSYFAGLFPGSSSSSTTNLPTTTTTINSSNNGNINSHQSSTINGQRNRNLSPSPTGTAHHHPSSSMNHVGHFNHNHHHGMIGSGSSNMTINSNLNHPQTLAESAWTAHLTSHLASIISNHPLNQSQQQQQQQQTNHHGSNIQTTSATNNRSTPSSTTTSTTMINTTTKTMTTMNDNGNREGQLSSSSSSPLQSPLPLPLPISRPDSRESPSVDVITDINDENSQSQQQQTSDNNNNGGNSTPSPLPSPSSSSSSSSSSSSTSSSSSSNQHQEQQHSPEPLSLINRSRTPSAFRRTSTANSNHHTNNVSSSSTATTTAAAVISTTATATANVATTSLNHLAITNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ65</accession>
    <name>A0A922HZ65_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">UQCRFS1</name>
        <name evidence="17" type="ORF">DERF_006816</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ65"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rieske" evidence="16">
        <location>
            <begin position="216"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="539"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9516052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="623" mass="70916" checksum="20A6BD8C9B2FDBBC" modified="2023-02-22" version="1">MIQSRSIGIGQFAKAVTQACGGQRITSSFPSLKRDWETRAVTLPELVPAFAMNMPLHKINLKPTFNLNVHLFRNKSQAICGVGVSHQYRLAHTDVSIPDFSSYRRPSNKDLSRRSAESTDDRRAFTYIVTAGVGVGGAVAAKHMVQGLLNMLSPARDCLALSKIEVNIGNIPEGKNVTVKWRGKPVFIRRRTQKEIDQERAVDINQLRDPETDEKRAPNPEWLVVVGICTHLGCVPIAGKGDFGGYYCPCHGSHYDASGRIRKGPAPANLEVPDHVFDGDTLEKIKISVQSNNYSQEMALKKICLEICFYVVLNCLCTASRNYYFFQVILKMDHENHVMSCGRPQKMPIKSQRLRNPFLLKIDPESLKVDNYIDGIKLNIVCECSFWLFSFWAVKIKEFHEKLAYDWMTIRNLLIDNQFNNDHFAYHSNDPELYQDEYNKIIHKIKAPDQFDSTFFTTTPRDRYPLAIILLLNDRELEEQLNSNDIVMLASIIHLRDSLVPLSTSVIGQYIKRQSGIVLNLQDLYICSDQSNEDHMPNCIICLDNHITRAILPCRHACVCSNCFEQINTCPLCRSPIQNFIMINQPIQTAMSDEGDDNLRSENVIDTHQKESLLHKIQKFFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZI5</accession>
    <name>A0A922HZI5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SHC3_1</name>
        <name evidence="3" type="ORF">DERF_006939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZI5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01209">
        <property type="entry name" value="PTB_Shc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000377">
        <property type="entry name" value="Shc transforming protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051235">
        <property type="entry name" value="CEP152/SHC-Transforming"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006019">
        <property type="entry name" value="PID_Shc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337:SF11">
        <property type="entry name" value="DSHC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337">
        <property type="entry name" value="SHC TRANSFORMING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00629">
        <property type="entry name" value="SHCPIDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="586"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9516180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="899" mass="96567" checksum="9A45BBB6614A233E" modified="2023-02-22" version="1">MLFCLGASVPKEDEYHFLSEEDDEVDDEVVVVDSIGHRLIGHHHHHHHSKACDIDLECDAANAGQLIDLAAVAAVAAAAVSDSKSQEANDNCINAGLLAAAVQQQHQQCSCCKSSSSVNCSSLRHVHQLNYRRKFHKLSCSPHHSTTSKFVDTNSSLPSSSSSTSSLANRQSGGNTSSTTITSTSAPSLPTGNTSSGGNSSSAASAFLSKLGPIQLGRKLSQLRNSALNNSSASHSSAVTKGTENLQREALRKSNELGQYNLDNSQRYIRLPPSPHSKKFSTAINVSQRSTSPIGEKCSHKLKCNNNSNINKSGCLPAKQSPASNIIDSLFMCDVLASPIQSIPTQFNNHHSNSPSLASHTASTQLISNRSCTSSPSSSSLSSSTISLTPAPTPPPPLPPHNHLLSNSSVSTLVPRSANNNPPPRPKADKPNKHQHQPLSNMSSTSATTNMNRSLLTNNVAVLSSTTSLVSSIPSNVSGNNVHHSHDTTNGIQIESCVPRSCTCSPSSLISSSTTTQPSLNQCATCSPSTGGNPVSASGSSNASNNQQTTSNNLNSHHHHQQHQQFINKPPRGWLHPDHKLTDTDGPGVTYTVRYIGCLGVNTSMKSLDFQTRSLIAKESINRVCESAGLKTVDKKRRIDKRIVGMLADAPNMEHAGVDANLSITISYLTLTLAETGEPLAKHEMPNISFASGGDTDTLDFAAYVAKDTRFERACFVLECEDGRAQEVITTIGQAFELRFNEFLKRNPLSTERLEHGHLGTNNNNNGHNHKTAMANNNDNCQITPAQRIEDREYYNDLPGKIPPDIMAINNGSSDRMNKMIPPLAAPRSKKSAITTTTTPNNPQEEQINLIDLNDDLKPPLTTTSSAYNSNLFSKQIRPTDSQYVNCGASDTTTTHFHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZR9</accession>
    <name>A0A922HZR9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZR9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7599" checksum="F403B4DECB0A9C96" modified="2023-02-22" version="1">MVAWHDLYLYIVDHHHLHHVVIVGVGSRPDRHQSTTNDDSSHGGKCYKRSEPLVEHHHLDFRQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0F8</accession>
    <name>A0A922I0F8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0F8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="89" mass="10433" checksum="AA7AD77E3D1323C5" modified="2023-02-22" version="1">MAIEWSSVNLGQQATYIMTNNIGTVQHLKRTDHRKTQRLANIITTMANNNITIMWHKVDRENRWYRNLKQLARRTASTGTGIMITTEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0G7</accession>
    <name>A0A922I0G7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0G7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="7304" checksum="261CBFFC2A4A8972" modified="2023-02-22" version="1">MPKTEKENAAQKECGCSAAATRVGDNGVGFVQSVAKSGTTTTPTLLTGKCLCGSDCKIAIREGDCDRKMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0H3</accession>
    <name>A0A922I0H3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Glucosylceramidase</fullName>
            <ecNumber evidence="5 12">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_007017</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a beta-D-glucosylceramide + H2O = an N-acyl-sphingoid base + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:81447"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83264"/>
            <dbReference type="ChEBI" id="CHEBI:83273"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:81448"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + H2O = an N-acyl-15-methylhexadecasphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:34755"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:70815"/>
            <dbReference type="ChEBI" id="CHEBI:70846"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:34756"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="5 12"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0H3"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000030">
        <property type="entry name" value="Lysosomal acid glucosylceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="14">
        <location>
            <begin position="113"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="15">
        <location>
            <begin position="466"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9516263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="533" mass="61937" checksum="E03F39CE581C4227" modified="2023-02-22" version="1">MKTTKMFSKSKYFMIYISLFMILFVKINYANIECQRRYYDQDSFVCVCNEKTCDTFDQLKKTPIGVVQVYETSRDGFRFQSSHINFTNDDNILSNNDDHIRINVDKTKKYQKIIGFGGAFTDATGLNIATLSEKLQSKLIENYFGSNGIEYTLGRIPIGGSDFSSRPYTYDDYNDDDTLSKFSLQMEDHQFKIPYLKMAQKISPNKLYYYGSPWSSPRWMKTNNDIRHGGLLKGQPGGKYYQLFARYIVRFLQEYEKQNISMWGITIENEPAAGFDSHYQWNCLGFNSSLERDFIKLDLGPELYRNGYTKNKLAVMIYDDQMPQMKTFTETVMSDEEAAKYVSGVAFHWYHNDEADRRDMDKLNAQFPTIFLLATEACEEWKNYPKKVHLGSWHLMNRYANNIIQDLNHYATGWTDWNLALDLKGGPNWVGNMVDAPIIINATANEFYKQPSFYAMGHFSKFLPPNSTRINFKIESNHVHAIDATTFLRPDGSLVMVLLNSNQQTIPIQVYDPERGHFQLVMKSESIATLLWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0J7</accession>
    <name>A0A922I0J7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DR1-associated protein 1 (Negative cofactor 2 alpha)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DRAP1</name>
        <name evidence="5" type="ORF">DERF_008529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0J7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9517911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="364" mass="39897" checksum="8BE88D31B201A3D9" modified="2023-02-22" version="1">MPSKKKRFNARFPPARIKKIMQKDEEVGKVAQAVPVIIAKALESFAEQLLTISSEVTRARNARTLTPNHIKTAILNKTEFHFLSELAQSIPDVNNTADDDPPTASSSSSTTITTTINPVLAHQQPQQQQQNPTSSTPSSSVMVTTKNSSSIITSEIPQIVNNNNGCKVYQATPIPTTTTLAMVLPQPPIIQKNSSKNHKTRGRGRPRKYPLDQQQSCSASASTSLQQQDNGQHQTLKNKQPQSTTTRGRRGRPPLSAKSGRKRRKAETSDDDDDDDDGESDDIMDDEDLVDDDDTEEDVGDENGNNNDNDNDYDDKDNMSNNNKTISTIKSSNLANFGTLATPPLPATSLDGTINDDEDDYDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1F1</accession>
    <name>A0A922I1F1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1F1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="9561" checksum="11D6B0306493C0F6" modified="2023-02-22" version="1">MPIPKGIYHLFNITILYRVALLCLLTINSFSSGSKERNYNSKNQISKIKNRISMRTNDSNTAGHLEIDYKFLFENTFVLDSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I276</accession>
    <name>A0A922I276_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Abl interactor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ABI2_2</name>
        <name evidence="13" type="ORF">DERF_008339</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I276"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098858">
        <property type="term" value="C:actin-based cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11826">
        <property type="entry name" value="SH3_Abi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000002">
        <property type="entry name" value="abl interactor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028457">
        <property type="entry name" value="ABI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028455">
        <property type="entry name" value="ABI3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012849">
        <property type="entry name" value="Abl-interactor_HHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10460:SF0">
        <property type="entry name" value="ABELSON INTERACTING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10460">
        <property type="entry name" value="ABL INTERACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07815">
        <property type="entry name" value="Abi_HHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="471"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="337"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9517695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="529" mass="58827" checksum="D1DF6EB8E9B9CCEB" modified="2023-02-22" version="1">MVMETVINPELNEHLNSNGQSSQQQHTTNLEELCSLLRNEVPESRQTLLDTQSNLEKVADYCSTAYIESDDKRFAFENTKNYTTHSLASVAYQINTLAFNVLHMLELQTNQISEMESQMNYISQKFQFHNEKVARRKIALLTSAKTMVRQPKVLMPANQEKQSKYIRKPIDFSLLDDIGHGVKISNQSNFLRSLNTTSNSGRMSGVQTLGPKSSMSSLSHYHHYNTLSGGSGPAPTTKPPTPPQAIRSGFGTLSRSSQNKEYRALVPPIAPPQVPKNYESNYPIGHPKSAIIHRQPSITGSTGSGTGGGYATGHHHHQQNNQYMAGYSHYHPGSSAVSLNSNMYGHTTNNNNNNNNQQQINTSLDNNNNNDNNNCPPPPPPPPLPSAQLDPNDSSLPDPPSPSNIQQQQHHHHHSNYDGRNTTASPPLPPPPPTIDNVHHGINHHPMMNKQHSIYGTSSMRQNVPDWVPANYIEKVIAIYDYSADKDDELTFQENSVIYVTRKNDDGWFEGVMNGVLGLFPGNYVEPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2C6</accession>
    <name>A0A922I2C6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_004870</name>
        <name evidence="4" type="ORF">HUG17_7792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
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    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Acyl_transf_3_dom"/>
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        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
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        <property type="entry name" value="O2_lipid_transport_reg"/>
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    <dbReference type="PANTHER" id="PTHR11161">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="6"/>
            <end position="25"/>
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        <source>
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</entry>
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            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
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                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">Derf</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="EMBL" id="KAH9517875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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    <sequence length="106" mass="12298" checksum="674D4B77FE63CFB4" modified="2023-02-22" version="1">MEMYKMSDSSCRLRTTSSVIKIFTADGPIIQNLLRYVHFGFVEFEDNIVAINFDCSSLTMDNFDLILFQCNALYNRIPSVRPQICMRSSLDNIKKSKPEKFSNIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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            <taxon>Astigmata</taxon>
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            <taxon>Pyroglyphidae</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
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                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
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        <source>
            <strain evidence="4">Derf</strain>
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        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="814"/>
            <end position="835"/>
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    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="204"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="337"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="440"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="539"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9520847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1010" mass="117155" checksum="B7C3BA8477001C75" modified="2023-02-22" version="1">MFITTGRFNRFIYGYQKHNNNNDNNNVRPFHHHHHHHHHHQRHYGGSFNHHHHHFKSNLQKSMTDVVMLIFWFKGLNSKAPFLTIDTRDHYISGGDYQQMTTSAKPLEMIINKQAAISRVNFESKSNFLKFNFSNVSNEAMFQTNGVTDSFLERTTYRIDYQQQLAYLFIERILAEDEGIYRCRVDFRHSRTINWFIHVELIIPPTKVFISDHNHTLITDGGLAGPYLEGQYIELICETKQAKPLPQVLWYEGSTLIDDSYELVSDSDSRHNNVSTESSDMNTFNYLYKTLVRARNRLKLIQPLIRQDLFRQFRCIAMNSEMIEPVASMVQIDLILPPINVEIVLDTKEAFHKGQDAQILCRSYGSRPVAQIHWYRNGQRILSRIEDYYDIEQNVSRSIMNFVPDENDDGIEIVCQSINIRLDQNQAVQDQHRITVHYMPIIQLSLYETNEQNLLAENSSIRLWCRINANPFPNKSAIWFFNSTRITESNDRFTILDNNQLLIDCLRSEYHDGYYYCLAENSQGRNRSNDFLLQVSYVPRCRNSETSISVAINQTKAIVCEVDARPSLVYFNWHHNNNNNNGTSITVNRLKYTTRGSTQSILMFTPRDHYDYGQLSCVAQNSVGKTVKPCIYTIRPYGPPEPIYKCICQYNYNSGVDGGSGIDIYCQLEIYRSIDNILIWNITNNVEQIDSCVFDFPISWLMANISDHGENRIQINVRTFNQQGSSKPYVFHTHLPIAPSSSSSSPPSSIFTTSQSSNSLIPLILNHISDLNDTSSMNDDDDDANKLVPFVWDLSNIQHKGQKLFKLLTDNGNWIFAFVFLLLAILMGFLVRTVVRIQQLKQNNHHDEHIIRKRYSLPITNSNDDQPQDRTFELEMITSLQQQQQHQQQQHCLIEHFDHCPLYDRQLQTIIQSRNNSQHVHFTSNDNDDDDETVIPTKKKTLSLSSSSGLVIVNYEHVMTLKTLDLDVLLGGQLNDTQQQQQQQQTPFTSFGQEDHQITRQTKSPMTLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3G9</accession>
    <name>A0A922I3G9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3G9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6944" checksum="0279E7695F15CE50" modified="2023-02-22" version="1">MTNNDIQVHNDDDDDKDDGGDKNFFLAIHFQMTKTMIKIEDIYRALQSSSSSSYSHQVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3I9</accession>
    <name>A0A922I3I9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3I9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027854">
        <property type="entry name" value="STMP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15054">
        <property type="entry name" value="DUF4535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037220045" evidence="1">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7217" checksum="DF7EF08659521F16" modified="2023-02-22" version="1">MLRGLLIFAAGVYTGIYASQNYDVPQVDKPQELLNRVKIWLNDIDRQYRKSGPSKKIFIIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3J7</accession>
    <name>A0A922I3J7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3J7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="75" mass="8904" checksum="DBFBA8B88028304C" modified="2023-02-22" version="1">MDPDGYYIPVIPKKKEILNRMLPLIQQGKARGRRGQYFSSNVTCKFRYHEDNVVAIIFEQVITQRTTFVFFKFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3W1</accession>
    <name>A0A922I3W1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_005641</name>
        <name evidence="11" type="ORF">HUG17_3398</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3W1"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7639365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9522037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="336" mass="40797" checksum="AD10B23086CAAAD0" modified="2023-02-22" version="1">MWWKLSQLDFLFEYVGMTPDYRIKHFLWINVSPVLSIWAIINFVVFAKVLGPELMRGLPAFDVRWLMFIYNVTMSICNCFAVYKTITLSDYFRVLWNFDYPNRMDSSTKTLYLIHLGYLYWLSKLLDLWDTSFFVIRKKFSQVTLLHVYHHTVVPLFGFILMRVNPVLPCVFLFSLVNSTIHVIMYSYYGLAALGPWIQPFLWWKKYITILQLYQFVLYGFYGMAIWIFGQNYPVYWLYIGLTQPPLFFWLFLDFYMKAYNRNAMDIWRALLMYRRRRQRQQDQILQEKSMKRTHDQSFVMNDKNDDDDDLYLKKDKSNHQNMIENNGLKQRIIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4L1</accession>
    <name>A0A922I4L1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4L1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9405" checksum="7BD7855DE09785B7" modified="2023-02-22" version="1">MKAAANNDFIFKDDDLDWDLDFIILFTSINLMGVANEILSFNLTLKAIPFIDDVDEDDDHDLNIIDIELFMTFTQAIMCNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4T2</accession>
    <name>A0A922I4T2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4T2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6910" checksum="D467F469971880EE" modified="2023-02-22" version="1">MFRSVFVFVFASTFTCQTFGLFDLVQLPPPQPLHFGLFNFQISKIHSVWSVIDFVKQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4X0</accession>
    <name>A0A922I4X0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4X0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9518041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="98" mass="11824" checksum="CAB156E5037D18C5" modified="2023-02-22" version="1">MVCIWPKKKVKERDLLHITVAGLLPFEYTNIYDFVNQISTTKISFNDYYHHVDNNNPEQQQQQQQQQRQQRSFSSFDGRLILVKDFQILLLYVRTFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I505</accession>
    <name>A0A922I505_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_004451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I505"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="965"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="560"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="774"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1028"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="1105"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1153"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1227"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="70"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
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            <begin position="621"/>
            <end position="644"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
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            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="895"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
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            <begin position="1114"/>
            <end position="1139"/>
        </location>
    </feature>
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            <begin position="1160"/>
            <end position="1179"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
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            <begin position="1180"/>
            <end position="1192"/>
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            <begin position="1227"/>
            <end position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9520761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I522</accession>
    <name>A0A922I522_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_008713</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I522"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="EB_dom"/>
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    <dbReference type="Pfam" id="PF01683">
        <property type="entry name" value="EB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037542133" description="EB domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="EB" evidence="4">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="368"/>
            <end position="427"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="470"/>
        </location>
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            <begin position="303"/>
            <end position="319"/>
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            <begin position="320"/>
            <end position="335"/>
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            <begin position="368"/>
            <end position="403"/>
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            <end position="427"/>
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            <begin position="442"/>
            <end position="470"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9518116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="512" mass="59170" checksum="F38AB247283FF9ED" modified="2023-02-22" version="1">MSSSWFLLLWLLMMMKNGLKTLNIQSSSSSSSSINLILIFIIMQSIILSSTSLFKCHFYCDAFSIQQQSKTMNKLSILNNNNTLPSSSSSSISYNNDNQSTIIEQLLLFRHKRDEEPAPIYGKGIAFWLGEHCENTCNRILFHVWCNSTTHRCECLQEYPVNVENKYCLKALQINDRCEYSEACRYLNPNSECNEQGFCKCLKGYFVKYDDEKESRICMAYDSPFFIRIGSTTFDFINKIEFITLFSLIISFILILILSMMVIKLMKKNKKLAKNDQPSFCDMIPPPPPVIMNAQPDRYNNQHSHHHHHHHHHPFHHHQTSSLQSTPSRSPFHQDYSLQEKTPISSYNIPPLPSNLNDFRRQSLSSLRSQSSLKSLSSFRSQHSYRVNNNNNNNNHSNQHQQHPMSSYHRTIHCQQQSKLRPPSHQTSYHDLRYTRQPLMASGSSPLDSQTDQSGFQLSNHLPTNPITSTNTIDRSRIKCANHRCGTGSKVRSEVCLVHNMPEMLQQQQQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5W8</accession>
    <name>A0A922I5W8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5W8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="139" mass="15341" checksum="F6911DBDF9E5BE44" modified="2023-02-22" version="1" fragment="single">NIQLFRIARLGEQDLHEQKVQLFCFITRLSPLKTIHSMSMNTDADATNDDDDHHNIPQQQQRRPNGAGEDDDIDGGGGGYNHVDDDDDGGGGGDHQHHHNVDSSIDDDNDGNDDDDYDDDGHMDAGFVSPQLMSRLSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I657</accession>
    <name>A0A922I657_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_006399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF6">
        <property type="entry name" value="ZYE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037895399" description="ZP domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="32"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="880"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="304"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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            <begin position="1639"/>
            <end position="1726"/>
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            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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        </location>
    </feature>
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            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <begin position="494"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="513"/>
            <end position="525"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="541"/>
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        </location>
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            <begin position="1371"/>
            <end position="1388"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1406"/>
            <end position="1445"/>
        </location>
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        <location>
            <begin position="1488"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1527"/>
            <end position="1550"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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        <location>
            <begin position="1590"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <begin position="1642"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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            <begin position="1652"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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        <location>
            <begin position="1709"/>
            <end position="1722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9522841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1815" mass="197951" checksum="AD53CE1B32EE7336" modified="2023-02-22" version="1">MILRLFICAILQFCIIGLTFGVVPQITRLNVQCDRSGMKVMVEFDNTFNGIIFSKGHFSDPNCRYVNAAGGQNIYEFSVSSSSCGTMANELIATTKGGNDQIPQGFKNVIIIQNDPDYQEVWDSARRLSCDWVTRLEKTVTFAPFGVDMLGVKELRFPGDTVDCWMDIQRGHGPFAPTIGGVVPIGEKLTVVIYVRDSDKSFDVHVKDCYAYDTPDYRNPNAHAIKLTDENGCPLKEKLVQGFFRTRDVRNSGATIIAYGIINAFKFPEKMDVFLACNVEVCKGGCMENVCQPIVDVAGQDSVASDDMASSDDGGTELATVDTTSTDEATTSTESPAEDGDDGDSATEDEEKKEETPSDGGDEEETTPEDTDKGGDDEEEEEIGGGDSENGKDVDEESNGNDGGGGGDDDEEKPDSESSTGDEDDEKSEDSVSSGESDSDTNGGNGGDEESTTSDDSEEKKEETTPDSDEESTVTTGDDEDEEKSEDSNGTDAGDSEESTGGDGGGGDEEEEKTTTDDEETKAADDDAEEQIVSEEKSEDVTGDDGEETTNGDTSLSSTAVAGKKGRNNEDEQIKEGDEAEITNGDGDDDETEEERKKRRISASLKLKAKKSSKVLKSAKKSGKVKKLAKSVASKPSSTGKKPKVTATASTSSKLVRKPQKSLAKKPLAALRKQSTTTTATSSAKKIVKKKSTTTTTTTNGKKPTAAKLVKKSASKSSRSSSSARLVRKSNKTKGKVSRPIVNKKAGQLKARKASLPANRTAKIRRPSSSSSAKLIRPMRQIRQASSPTAIPIELRRLSATLQHPNAGIVQEGRHVRTRRSVLINDTSIMNATFAPMIHSIQIISPIEDFDEKELNAWEKLMQLEGSVEEEVVDNNNNNNDDDDEIHRIPSFTIATASITGQHRQTSLAELNGHHSYCFSRIHLITASFYIQPNTSTQSLEFQIPVDQCGTNTLDIESENGEPAKRGFENIVVFQNDPIYQEQWDHARMMVCRYSMDDDFDSKDKRVIFKPIIIDMLDVVSIPIEDEDGTQSRVDCWMEISKGRFPHTMDIEGAVKVGSPLTLAIFVKDPRKRTDIRVKDCYAYDDPKVAESNGPALLQLTDFDGCPNRPKLIEVWKRTLDTGDTGATVIAFTTVTAFKFPDRPDLQLTCNIELCREKCSSRCSSEMPEPTSVGAWTKTTVDDGSTNTATTTDTKDENGGTDAGETDEDKDTDTATAEEGDAEDGEEEKTTDEKEGGDEGEETTADEEESSSDNGDEESKTEDDGDDEEKETTADEGGDDESSKMTASEETPAEEETSEKDGDEEEESTAEEGGEEAEPAAEEDEKEEASEEMAADDEENEQTGTDEETETTAEDETPAKEETDSSGEPTSTEEETTANDDETADLGEDENKSEQEIEPTGTAGSEDGEEEQQASGEDESENETTSDDEEQDETENGTEDEEEEDEKKKARLQAAPTTTTTTVARKKISNVVTASKSTNKSKSKSKTKPTTTSTTTTTTSTTTTTTTAKPISKIRKSSKKPKEASQRKSSTQKSLNNAQRRAQIMDTSENSVDEIRSSSTKLQQQQQSPKTAASGNKKISKATRLKDILPSQPQQHPQSMMMANHMSTTTLRPLKELANSSNTSNQNKNKLSKITAAANAAKKLKSKRQKSKTTTTTTTTTTTSTTTLPPKPMKKMSKIKSSNQKASVDTKSGNLKRNTRHNSAEQIEMNDNNQNQSSMMMNGSPRQTSSLIANRRQSPYYYGIVDDSPYEMDALRSFYAYSNFQPQRIRRTRRTIRSVDPIKWSHSNGHNNNNNQKGATISLGARVISGLEITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6X9</accession>
    <name>A0A922I6X9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_000614</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="12"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6X9"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000002">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="14">
        <location>
            <begin position="190"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="11">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9526537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="363" mass="42736" checksum="ED36ADB71EEDF38C" modified="2023-02-22" version="1">MDKFGSIDYPHNRYNPLLDEWILVCPHRSKRPWMGKIEKNEDEQNDHHDSLMINALSPGGVRSNGNQNPEYKSTFVFDNDFPALIDDDCPADHTDANDDDNQLFRIQSARGRCRVMCFHPSSRLSLPLMSIDEILAVINTWIEELKKLAPIYRWVQIFENKGAIMGCSNPHPHCQIWASRFLPTIAQRKDEQQRNYFKKYDRAMLWDYVQKELVNEERIVLKNEHWLALVPFWATWPFETMILPHHRCIQRLNELDENEKQSLAVIMKGLLTIYDNLFETSFPYSMGWHGAPTGGGDDWQSKQQYQHWILHAVYYPPLLRSATIKKFMVGYELCAQSQRDITPEKACEILRQQNSNKHYKHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8P5</accession>
    <name>A0A922I8P5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">HGH1</name>
        <name evidence="6" type="ORF">DERF_005662</name>
        <name evidence="5" type="ORF">HUG17_3382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8P5"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="120"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="298"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7639349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9522059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="377" mass="44444" checksum="E89F198763543534" modified="2023-02-22" version="1">MNSTFEVLIKAIMANDDLEKREKFIRRNSAKIVPLVHWLCKTICSLETNDCNDPERKKSHNEDESNSNDLIRFSLDCVLIISSAAASTMDSDKQTSEQISQAVMSETDFLHHLNDHITNEQITDLDRHLGILVNFTRHISFVQSLVTNVLNPFPLDKFISGFQTKFQSKECQKSRPLMVAYLNNLCQCEEIRNRLIDGKVLHSLMIIYDYHQEDTNDHIELRLSIIELIRNCCIDYRYHERIISEEDPELLVRLVMPLAGGEVLTDEEMESLPLDLQYLPDDKQRELNADIRRLLIEAIHQFCSTKYGREIIRSTNIYYHLREYYRWEQREDLREVLMRLIDVIIKKEDEINVDNLRELEIPDDLMEKFERLDHGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I991</accession>
    <name>A0A922I991_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I991"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="174" mass="20392" checksum="8F5669120B66C4E3" modified="2023-02-22" version="1">MVILLTSRLETIESTNSRSNNNGNNIVKNNHENFALNQVVKYNGSNIKIWLSTVKSAFRSCGYSKFLESEILPNDPQYNSYENCLGTIRLMFESNKLEIIQRQLSNGNQVRVKFTKGNIFKNQLLIGFWFNNDITNFFRFNCFTTSCFKLNFLKFRINKIFIINCESFKSLYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9N2</accession>
    <name>A0A922I9N2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CDC25A</name>
        <name evidence="10" type="ORF">DERF_005541</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="7"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9N2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010256">
        <property type="term" value="P:endomembrane system organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009794">
        <property type="term" value="P:regulation of mitotic cell cycle, embryonic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000036">
        <property type="entry name" value="M-phase inducer phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="277"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9521928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="441" mass="51179" checksum="60C6804BB33A91CB" modified="2023-02-22" version="1">MDESLMSIELNQSNDDHFDDDEFIQETLNFSMNQNSSISEFKIPSPVSELINNEITTTATTTTVTLPKCRLDFNVSDTETPRNSLNVVRNRKRTNFSRRCLSTDLNSGDHYETDQMSFQEFRFSNQTSNDFKSPLILSSIENKISPRTTPKHFSHQQHMTLELTPEFNNTKQLSSSLKPFDENDIIPKAKCMKSSLTNAVKCDGGGPSNVPLQKYFSENHASIMRAVQRSSDDSSLIGDFSRTYALPLMTNSKHQDLRSITCHVLAELMQNQRYSHQIRSFTIIDCRYPYEYDGGHIQMAINLYTQEQILNRFIKTKPKEAGSKDSSNDEDDDDDKTANDKRDILIFHCEFSSERGPSLCRFLRNNDRVKNSRVYPKLHYPEIYLLDGGYKEFFQHYSHLCEPCAYKPMHSKNHEEDLKKFRTICKSLDYKYSTRKRNLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA69</accession>
    <name>A0A922IA69_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine rich trypsin inhibitor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_006355</name>
        <name evidence="5" type="ORF">HUG17_2922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
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            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA69"/>
    <dbReference type="OrthoDB" id="6490487at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
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        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276960" evidence="3">
        <location>
            <begin position="21"/>
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        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="27"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7638889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9522794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="94" mass="10546" checksum="AF66721D6DCA2756" modified="2023-02-22" version="1">MNMKIATILIVTLFVAITLADPIQQTCHDNEEWKECGTKCPDTCLNRDIKNRACIKMCVTGCFCRDGFIRLGYDMTGGIGHCVPVDYCDLIPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAD6</accession>
    <name>A0A922IAD6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Pyroglyphidae</taxon>
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            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAD6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="153" mass="15510" checksum="90369BF8DA58C070" modified="2023-02-22" version="1">MGLGAAATNNSTGSSGSPLISDTESRGIRSTTLSTPASSANIAPQSSSVTASSPVNQSPPGLNLSSLHHHHLHQQQQQQHHHHQHQHGTSPTTTATTMTTSTTNPDTSAVTCDESLTAAFGQAAVAATHLLDIKDVIGAANGGSCDQQLNGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAL9</accession>
    <name>A0A922IAL9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="78" mass="9548" checksum="B3ADCC8B5A1E0177" modified="2023-02-22" version="1">MDVFECIIYQKNSKHIESFFYTLQQQRRYIDSKFSIHKSIHYHYILCFGLAVLLKLFFFNLKTSAILRFKKKLHPMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBC3</accession>
    <name>A0A922IBC3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001889</name>
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    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
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            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBC3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="50" mass="5226" checksum="BD9AA3E6F142E835" modified="2023-02-22" version="1">MDFQSMMETFAEAWVAANTQTPLTEAAAAAAAAATDHSMVDSGNEKYTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBU5</accession>
    <name>A0A922IBU5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_001899</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBU5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9527912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="228" mass="27128" checksum="1F4C7F43227E8EE6" modified="2023-02-22" version="1">METKKSQTRQQSPPMVKHYLAIYNAVQFIGWAYGLFLTIRFLLFSPERHNYRLLWEHCSIIITIFQTYQLIEVFHAMIGFVRSNPFTTFTQIFSRLMLVWGILIPLSEARYSIGVPMLLIAWCIAECTRYAYYALNIYDAVPYICTWLRYTLFIVLYPIGVSGELFTTYAALRPIRQQKFLSFDLPNKLNFSFHYDVYCIIFMLSYIHFFPSALSLHVWATKKDYWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBU8</accession>
    <name>A0A922IBU8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosylphosphatidylinositol anchor attachment 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GPAA1</name>
        <name evidence="2" type="ORF">DERF_001936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBU8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036762">
        <property type="entry name" value="GAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="661" mass="75725" checksum="46E2AB7E7CBAAAF2" modified="2023-02-22" version="1">MYLESQSEERMSILTSDDNNKALTFIKKLVRFNVIISLISYLAGWSFFAYLIHEPQKTSFHDNSLLPGLASREFVAANQAERLVHQLTNLSAEFHEKYFPVKFLRKQFEDIGLEVYEHKFRFTYPFGYEKPAVEGLNLYAIFRAPRAASTESIVISAPYRSPSNPNGSTLPSIALMYSLAKFFKTKNYWAKDIIYLISGNELLGIQAWLQSYQGLENRFDQYLQSDVLLAKAGAIQAALNLELQSFSPPYVQVKLEGLNGQLPNLDLFNVAVELCNREAVPVVYHGESFYMTENEWENWKRKARTMVSMMATQATMLPTGAHGLFQKYAISAITLEASDRRAKYVMVNGLQLGRSIEGIVRSLNNMMEKFNRSFYFYLLASTRRFISISSYMIVFGLLALPLACRSLFYYFQSYNSIGQHITGDNNFDFWASFKPCVLAHLFGLLAVGIVPLVLTRLNIFNMIMFDVPVAILAYVIFIILAIISLNLPGLMTAHAKKSINQYNLQSMVTLLNTLLLLTSISLINISLAIALASIYVPLLSIFSIQDHHRSTKSSTLLRRICNLFKTITLLLIHPITLHLICLFGLSIWMDPDFKSLRKLPINDLPLLLLKHLKRSFQSQPRTMMNFIEDWYLFDNWAFPIVSLFLYPVWLQLWFQSFTIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC34</accession>
    <name>A0A922IC34_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase [NADP(+)]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AKR1A1_4</name>
        <name evidence="4" type="ORF">DERF_002656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC34"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF14">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9528739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="305" mass="34638" checksum="53E1696CD73C1D08" modified="2023-02-22" version="1">MATSPVWSVKLKDGVQIPILGLGTYQAQGDDSEAIITKAIDNLEPIGEAVKKAIADGKVSRKDLFVVTKVWPTWYGPDRVEASVRRNLRESGLDYFDLVLLHWPTVFADSDTEKFPMEPGTDNVIFAKRNIVDVYRDLENVQRKGLTRSIGVSNFNAEQVERLMKSPVSIVPVTNQVECHLYLAQFDLQNVCAKHGIILTAYCPLSRNRPGEQSVLNDKTVESIAAKYDRTTAQIAIRWLIQRGIIAIPKTVNPERLKINFTVFDFEISDDDCKILDSLDQGEKGRRVWFDMRNNLREHPEYPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICJ5</accession>
    <name>A0A922ICJ5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICJ5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="116" mass="12907" checksum="F2500FE8AF0B50FC" modified="2023-02-22" version="1">MSSTPPKIDAPNFERNGFHTRYSIFCPFSTSTDIRFSPYTDSPGTKFLVTKASSLPRATKMPANRAPRPPPRPPPLPPRWPNPPRPPPPPPRPGLFPKPPRPPPRSPNLPPPRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICW0</accession>
    <name>A0A922ICW0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICW0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7629" checksum="BB422D3F7D8ACFFB" modified="2023-02-22" version="1">MPDVVPPTFSWWLSHKAYPGSWPIRQFYSDSISDDQPGNVATISHLSSPTIDCHSRAATFSISNHDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICY0</accession>
    <name>A0A922ICY0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multiple coagulation factor deficiency protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MCFD2</name>
        <name evidence="7" type="ORF">DERF_003123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICY0"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052110">
        <property type="entry name" value="MCFD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104:SF17">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23104">
        <property type="entry name" value="MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="126"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9529231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="216" mass="25401" checksum="6AA8DAE41A7E8FC5" modified="2023-02-22" version="1">MMNNSVLMLSYTIVLSLILLFKLPYNIAHYNQPQYGIPVQQHQQVYHQQPPPQQQYQQQQIPIQQQQQQQQQQVVYQTPGQIPHYQQVPQAGQNVLHDDSRIHDKEHLKEHLHEALSDQDVSKMSEEELQFHYFKMHDNDNNNMLDGSELIKSLIHWHVEESRHLGKNASPHGTTKIFTDTELEQMIDPILQMDDKNNDGFIDYPEFVAAQKNRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDT9</accession>
    <name>A0A922IDT9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Retinoblastoma-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RBL1</name>
        <name evidence="11" type="ORF">DERF_002779</name>
        <name evidence="10" type="ORF">HUG17_4891</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the retinoblastoma protein (RB) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDT9"/>
    <dbReference type="OrthoDB" id="844594at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002720">
        <property type="entry name" value="RB_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002719">
        <property type="entry name" value="RB_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028309">
        <property type="entry name" value="RB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024599">
        <property type="entry name" value="RB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742:SF17">
        <property type="entry name" value="RE32990P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742">
        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11934">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01858">
        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01857">
        <property type="entry name" value="RB_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01367">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01368">
        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Retinoblastoma-associated protein N-terminal" evidence="8">
        <location>
            <begin position="65"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Retinoblastoma-associated protein A-box" evidence="9">
        <location>
            <begin position="383"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7641846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9528872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1179" mass="134042" checksum="373CE84CF06B7624" modified="2023-02-22" version="1">MDSDDQYDEEELHSFLLTEIRSGLNLDNETLEESWKSFRSISVKYILEGDKMDWLACALYISCRKCTTQTGRGQTRIEGNMVSLTRILRTCNISLVRFFNKIKNWIDMAGSSVDLRKKIDQIEKNFNVTSVIYKKYKPIFEEVFKCPVPPCRFSPKNRKIRKQPLNSMDIFTFCWTLFVFVKSRFAKIGDDLVNSYHLLLVCVDYCFSSVLSFDNYRDIVNTNFYDKLTKELKNDLRSLNNDERVSIIDTLCEKFNGIPVEVKHIRQHWFKSLLNRLSDNNNLRKRTNGIIDNDAIDFNFKYIKKEYEDFVLTIGDFDECIFLNEEASKELGTAELQSQFDIEEKLFQQQVSYDTSKDTLVPATPLSSRQYLASRTPVNNILTPISSATTSISRLHSILQNHKNEPSRDLQRIFEMCDKDPQTKIKDIIKKMGNVFADAYAESNQDQSIIRSNEEFQCIMTSGREFANKRRVFAETFFYFIFEKILKGELSKRIPQSNITQSLSKMVSSELLIRSLYACSLEIILFSYNICNRVFPWILQIYDDHPQLKIPPFFFYKVIEPIIREEQGLSRDIVKHLNTIEEKILDCLAWTKDSPLWILLSKTPSPTYAEVSLDLFNQDGGENTAPFMKSPVIRSDSNNLMNAVYTGFSESNVKRQLFTNGNADASKSISPQTQICHDVSVIRSAKSISQTNTPVKQEIDENLVPSPKSSILSTPVNKNQRNSQIALFFRKVYSLASHRFHDLYKRLQITSDDVKCKIWTCFENAIQAHTYLMCEHHLDQIIMCCIYALSRININGDRSIQFGNIINEYRFQPQGSSIIYRNVLLSVLKKPDANSEQQQSETAASSSPETNGKFGSVIDFYNKIFLPNLTLTYILQFSSEEKNLNVKLSPMPRDKFASSNIQSPLRCVPNYPVFVSPLRKSKCASPSKNITYRFQNNLTTSKDLEQINNMMKSSTAAAAAAAHNPHISSLTLPSSNFGNHNSHHRNIKASIATAMISMSSLGGGAKRSVSKRILQDDNENGDSLGASPKKVPRRINLKIREIFSERRIMSASSSANASTSVSGDESNDSIQFNNTSANGNVNILASKMEISNKVDGRHHQESSHSTFESDDHTAISQIDPSMVQPAQKQQPILQPVVAQIIQQQSNGDIGSTASTATIVHHQNVIVPVTTITSNLIRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE04</accession>
    <name>A0A922IE04_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE04"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6736" checksum="25B3FB15A16297F1" modified="2023-02-22" version="1">MDPKLAECNRHHHNLMMGTNTFVSVFPLLYSNIAHRSNKFIRSFLSTTPSIPAYTIAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE28</accession>
    <name>A0A922IE28_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <ecNumber evidence="5">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PCK1</name>
        <name evidence="25" type="ORF">DERF_002282</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Derf</strain>
            <tissue evidence="25">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Derf</strain>
            <tissue evidence="25">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE28"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033993">
        <property type="term" value="P:response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07865">
        <property type="entry name" value="STKc_CDK9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000203">
        <property type="entry name" value="Cyclin-dependent kinase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000227">
        <property type="entry name" value="Cyclin-dependent kinase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.20:FF:000005">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="89"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="408"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00058806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00072283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAH9528330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1121" mass="125523" checksum="86EA4BE472726107" modified="2023-02-22" version="1">MSNNLPSHGGTINSIDSSSSKNSLHNHMRNITGSTTSNMPGNLHNPTSNHQQPPQSSSSSSSLASSSNINGPLPDNEYEFPYCEDVNKYTKMNKIGQGTFGEVFKAKHSKTRKLVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTSSTDSNYKATFYLVFDFCEHDLAGLLSNISVTFNLGEIKKIMQQLLNGLFFIHKQKILHRDMKAANILITKNGVLKLADFGLARAISDIRSDRYTNRVVTLWYRPPELLLGARNYGPPIDLWGAGCIMAEMWTRIPILQGNTELAQLQMITQLCGSITPEVWPGVEKLELFNKMDLGKNQRRRVKEKLKPFIKCDCALDLLDKLLILDPTKRLDSDSALNHDFFWTDPMPQDLGKLLSKYTSSMFEFTTPRRRAAPQAQQGGGPSAPGPHVYHPGHHPGGHQRGPPGRMGAQNSGGQYIDRLDGSYHPSSMINTDNVPSTVVRLTDLVKHRTMISVAYQKGHFEGAESLGCQTTKTSFNTVSSRGLTNLSAATLSDSVKKFIEDKARVCKPDQIQICDGSETENQQLIDLMVKQGMLEKLPKYENCWLARTDPADVALNKRDTIPIPKEGVEGTLGKWLSPEDLQKALDERFPDCMKGRTMYVIPFSMGPIGSPLSKIGIQLTDSPYVVASMRIMTRMGEAVLKTLGEREDFIRCLHSVGCPLPLQRPLKQNWPCNPEKTLISHIPDRNEIISFGSGYGGNSLLGKKCFALRLGSILAKREGWFAEHMLILGITNPQGIKRYVVAAFPSACGKTNLAMLTPTLPGYKVECVGDDISWMRFDKNGVLRAINPEYGFFGVAPGTTNKTNPNAMKTISRNTVFTNVAKTSDGGVYWEGLEDEIDPNVKITSWLGEEWTKDSGKPAAHPNSRFCTPAGQCPIIDSCWEDSQGVPISAIIFGGRRPEGVPLVYESFDWKHGVLVGASLRSEATAAAEHKAKVIMHDPFAMRPFFGYNFGHYLDHWLSFAEKPGLQLPKIFHVNWFRKDKQSGKFLWPGFGENCRVLDWIIRRVENENITMDSPIGYLPKRDSFRAEGLDIDYDKLFDVPKDFWKQEVTSIRKYFDEQVGEDLPKDMNEQLNKLEQRLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE91</accession>
    <name>A0A922IE91_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Metal ion binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">INSM2</name>
        <name evidence="12" type="ORF">DERF_003709</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE91"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001329">
        <property type="entry name" value="INSM transcriptional repressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042972">
        <property type="entry name" value="INSM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065">
        <property type="entry name" value="INSULINOMA-ASSOCIATED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15065:SF4">
        <property type="entry name" value="LD18634P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="646"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="370"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="578"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="692"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9529849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="729" mass="82623" checksum="AA340D9D9BD8913C" modified="2023-02-22" version="1">MSTLSHAATNGLNLSSVYERTSGHLSSHLSSILYNTNPNGISSKLFDSSKSKLQANRIDINDGADDDDADEEDDDEIQLNECENDSSVSNHSSITTTIEHHPNNHYQCPLPSSASDLIKSFSIKPMFDNHCFSKQQQQQQAPMVKRRNQTSVIVSPGHLKQENNSNGDNHSVKQTIVDDIYKTTIPMQNAISYMLGQANIDTIQQQRIEQTQRDCSLNAALCFAKNNILEYYYKSSNIITEELIHSSLPNGTSLSLKIKPNNFGDEDENVDQEDEEEKDRIADDDDNYDDDDDDGHGYGNHNNSEGNFNDEALDLRCHRKKEEPLNIRIPNRQINSEQNSSSLNEILFRSNTVICSPSLSIQSSLDSYHHYHQKEKEKSSFSELKKNHRYNRKSSNGKKRLNDSSNNDCGSGGKKMTINHNNNNNNNHKRVKTLRKFKFDEHKSSPVSGTFILDSDNEEEFTALMRQDCAVKRSGDIDPSLNIVIITPEARAEIAKIDNKIGDYVCALCKEYYVDAFALAQHRCSRIVHIEYRCPECDKVFNCPANLASHRRWHKPKSLSSLSSTTIMVTKNSLQISNHNHNHHHHKSSPRNQFDHCKSNNDNGMSEKKSKKIMVKATTILDNPSMANINTTTTTNKKVINNDESYNCNVCGKKFRKQSYLRKHQQQQQHGSILSDYDDDHFGSLKINSILTTTNNNDDEKNDNETEQSSSSLSMDGMINNNDDVDECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IED5</accession>
    <name>A0A922IED5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IED5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="305" mass="35481" checksum="45E3524DA96091A8" modified="2023-02-22" version="1">MKTVNECNKIYQQKILQPIGQYCKEANDLDLIRNVLEPRPKRQIDIIVKGIKLAYDNWGKILHVRQSVMGFASNWINSKRMKKLTETKDSNICKYEYGGPKYMIFNLAKDCVKELNIAPHQESQSFFINQPETCDESGTFTQKYWKQTSCQPIGLVDETDPDEIQIHYNDEFLYAYCYNQTTITIFNVTTKSEYQRKFGTLKIKVYENEILNNFILGKNQKYKSSSKDLEMLLENNGSTTSEENSSVILLIYSITITLIIIGILAGYLFYYYKKKIKRHPAVESHIETTKLRNFPSALAIAEKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEF8</accession>
    <name>A0A922IEF8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kazal-type serine protease inhibitor domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">Kazald1</name>
        <name evidence="10" type="ORF">DERF_003841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEF8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005520">
        <property type="term" value="F:insulin-like growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011390">
        <property type="entry name" value="IGFBP_rP_mac25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14186">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14186:SF19">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037251021" evidence="6">
        <location>
            <begin position="19"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="101"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="159"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9529996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="272" mass="30758" checksum="2D30655A31DBB2B2" modified="2023-02-22" version="1">MNILNLLLPLIVALFVTAKEITTEISVENSFEICPDECDPNGCPVPNNECLAGLVKDHCDCCFGCAQREGERCYEEKFKDQLPDDYPRYSKCGDDLECRIRTDLESTDKPEAICYCTMNEPICGSDGVTYENQCQFTEARYKNRNKLFEVDNQPCKSRPQIISPPEDTTNNTGSSVSFSCEATGWPLPTIEWRLERDGGVEIPILLMDEAHYEILTNQSTDYANISWLQIMDAQREDSGNYICVAINTEGEDKAGAYLTIGNFQKRFDIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEG3</accession>
    <name>A0A922IEG3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_002479</name>
        <name evidence="3" type="ORF">HUG17_10410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEG3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276983" evidence="2">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7636440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9528540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="133" mass="15293" checksum="501363237B9D79C6" modified="2023-02-22" version="1">MSFMASLLITAIIMLTINQNDKNTLVLCNPMMNLKDLNEESSSTLQTTLSNNQQQQEQYTAENDEWKNVLKKMTEKNPCGSNENYTMCSQCGQWTGSEDAFYLCCLNLDGVREYCISFVNYDLDVEQRKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEM1</accession>
    <name>A0A922IEM1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Group XV phospholipase A2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEM1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="46329" checksum="377CBDB1C5884335" modified="2023-02-22" version="1">MVKFFFAGCVLQFLVPGDGGSQLEAKLNKSSVPHYFCDRQTMDYFSVWLNLELLVPFIIDCWVDNMKLIYDNRTRTTHDNDGVQIRVPGFGNTTTVEYVDPSRLPISGYFGRMVEHFVVDFGYERGQNIRGAPYDFRKAPNELQDYLKSVKKLIEQTYRMNGERRVAIICHSMGCLVMLKFLNDQQQKWKDHYVQSFITLGGPWGGSVKSIKAFISGDNFGVIVAPSLTIRDDERTFPSLAYLLPNDNVFDTDRVLVETKQRKYSIKNYQQLFHDIDYNVGYNMWLDVRNITYDLTAPGVEVYCIHGIGHDTINKLIYDKNQFPDQQPDRIEYGDGDGTVNEESLSACKHWHHKQKQPVHYLPIHDMDHMRLLSDQNIMANFHHALKSSKKNSEKKEKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFY6</accession>
    <name>A0A922IFY6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">T-cell immunomodulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ITFG1_3</name>
        <name evidence="9" type="ORF">DERF_002609</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFY6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="8">
        <location>
            <begin position="350"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9528689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="501" mass="57617" checksum="9D84B741A306A760" modified="2023-02-22" version="1">MDVLVITQPESMEQLFKIWILRGNKTHLECKSTKKPLLDNALGHPLILDFNGDMITDFLIETRDCPYELWLMNSKHFRGDCRRNQFGDTSLRLPHSNAFVNIRNCLPDSLDYTTDIVITNKNHIEYWLNREGFNVENRINIRYPDESLYTIGQSAYIDLNIDGCIEHIIAACKKVGFFHTQCLPQILWYDNKQNEWINIADFTNHSKLYFETIDTQFGIQLPIAIRFGDVDSDGYVDLITVMKNKTESGRIKQIAVILRNIRDDDHPNRRKFVLFWTSEKLIPDDDVELVSFLDLQENGKLDIILTTKNSSNHYNIQWILNTFVDNSCFLKILVTSGLCSESSCPNEKVPYGTNQAGPFVCYETSDVNGHLMKGCSAQLSQSSYFALQMPYSIFGLGETPNFVETVIASIPSGDNQPTRKSKWTQIVPDAQVVLIPYPPNETMYWIGKLFYTPSNMISSTLAALAILCAVLIVIIFILHRKEVLEDLTEHEEYKRHWPESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG60</accession>
    <name>A0A922IG60_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sal-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SALL1_1</name>
        <name evidence="13" type="ORF">DERF_002822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG60"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001818">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000708">
        <property type="entry name" value="Sal-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000341">
        <property type="entry name" value="Spalt-like transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="278"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="419"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="483"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="483"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9528914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="619" mass="68795" checksum="F9F6428B1B54FF4D" modified="2023-02-22" version="1">MAAKHLNQNSNSLPLHLFNAANFPRISSNECSNVDLAEKDDDLATTDSDTSKDKRKTDTDDDRPNKVSTTVDDVRSISDTTEIEEEPLVSPIKKKKIDDKEKKNEENTLSALEHHVIKSTAEISPQSHRYHSSKNGHKITHDSTPTTDINDEQSSKTNDDTTNPYPTTPFAGLPYHPTGRPNTTCRICLKTFACFSALEIHYRSHTKERPFKCEVCDRGFSTKGNMKQHMLTHKIRDLPQELYSTISPSDNTTLGNFLTSNSITKIIGKQMNIQHHQNNVSTSSNNSNSSSRVASPHTPNGNSMDSDKFRNTESPATESSNNTTPRSSSSSSNKHMCNICNKPFSSGSALQIHMRTHTGDKPFKCQVCGRAFTTKGNLKVHMGTHIYTHSNPSRRGRRMSIDLPNLKLCENIVQNNSSSMAEHYQRKKSTEIPSSLPPVSTAASTATPPSLTMAISPTEMTTSTAANPEASQLALQQMMLMKMMSSQHQHQQQQQQRGKNDEGNNENKSYGNESKELVCEPEIDLNNDNTSRINNSTFNQRVDNENEKADDEDEMENHSFRSDQAIDDWSNKPLKCTLCSQVCHSPTEFEEHIKAHLHAAAVAANSMSATIKTTADVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGJ5</accession>
    <name>A0A922IGJ5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGJ5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="128" mass="14724" checksum="C0BF224C59C8AFB3" modified="2023-02-22" version="1">MFVHGEILDHLWLFLLIFGPLCASLHSIHNECTSIILLMCSLTNFHLLKIIIIIIIISLFVKTYSFVQNESDLIVLIYGCEFFFIIIQFLAIGSNQLVDLLNDEEKKIPLFARFAQHDALQILNFANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KW69</accession>
    <name>A0A922KW69_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Stomatin-like protein 2, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">STOML2</name>
        <name evidence="6" type="ORF">DERF_013304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KW69"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000008">
        <property type="entry name" value="Stomatin-like protein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="55"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9497309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="366" mass="41241" checksum="40BA5C4A175BD9FF" modified="2023-02-22" version="1">MNSATRYLTRILLKPDGFVPLRRPNRLALQFHSEQQPWNFQHQQFRLRHSARLNTVVVFVPQQEAWIIERMGRFNRILDPGLNVLLPVLDSISYVQSLKEIAIDIPQQSAVTSDNVTLHIDGVLYLKVNDPYKASYGVEDPEFAITQLAQTTMRSEIGKINLDSVFREREMLNIAIVESINLASNSWGLTCMRYEIRDITLPARVQEAMQMQVEAERKKRAAVLESEGIREAEINVAEGKKKSRILSSEAHLMEQVNEAKGLAEATRLKAEAKSKAIHIVGQSLRSIEGSDAASLNIAEQYIGAFSKLAKTGNTLILSSDAGDIAKMSANALQVYKTLSRPDRIDEELDEEDPEEYYSNQEDGNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYC5</accession>
    <name>A0A922KYC5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome maturation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_015963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYC5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9491232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16917" checksum="15DDAE46389B597E" modified="2023-02-22" version="1">MDRNNLHEQMIQYGHHANKHEFDRLKNPLKSTFIHGYSIIDSSIELWWPSIGTNGKTRLAREEYRDLQILRSVQGIQAPLRQLSERKAASNVGRLPFLRSSNLMSDVLLGHDELIMPENIFDQPNEYCEVNLPPHMVMERKLNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYG9</accession>
    <name>A0A922KYG9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 13D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">VPS13D_4</name>
        <name evidence="2" type="ORF">DERF_010723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYG9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF141">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="972"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9505960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1047" mass="117402" checksum="8189C0FD32728673" modified="2023-02-22" version="1">MVGGSMFGYNGGYMDDDAEQLMYMMMAGPDLSFVENDVGSKMLVLDVPDFDIPNSPMSDTFPIGGGGGGGILESDRPKPVFLGRKERAKRSQLWRLDQLNHLIHEGSSPPTEPPGFQDLDVMDDEMDNSSSTSANIVSIPLAVRKLNQQRSSTQTWYFTEDGRLRCLKYWNMFVQPIVLTTTTSTTTGLNDLFQTGTMAVIAIGPTESSMTKTTIPKQQAVIKQKMRKGSGVLNVSILADGPSRVLRIKDNQLTANGRQLNLIQFNRSDHGSNTSNGGGGGTSQLNELLNTTNTMAEQSFLIRMLNKTELELQLQVDSIGISIISKTNEEIVFLFMKKIILELLCNPAECRLNCVVEDFQVDNQLLDSEKEVVLYVTNLDSQHQQQQSDQEPSSPSSSRSISTITTMAGQRIIIERPAITFNLHKLFLPNVEINVFKSLQISINDLVLNIEELVLLKLLEFIQYDPVDSEMDEISSSSSAAIAAAAASTTATNPSLLYHTSGNVVSSSLSRSAQYFFAFLLIQLRRVKLSVFTSTSTIGRYLNELKKKAGIKLIRFEEALIQLKPFHKVYSLMTRRFLQDSIHEHYRSELRSQAAKILGTVDFLGNPVGFINNFVEGLNEFYSDGSIRGLIMNVTHGISDSTAKVTSVLSESLGFVTMDDRHQEIRRKIKQQTGGIGGQRSHLVVGAFGLAHGILGGITSVITQTYDGIVNHGGVTGFLSGLSKGVLGTFTKPAVGMLDFASGAATAVRDSSRKACFGINGRQVRRVRLPRTLTIDGRLTRYQSQQSQWQSRFYNTTDFGTQREYGEQFVHVFPLSDRHFVLLTTERLYFFHAPIRKCQLPSEDVWDDDDNHDHHGEFRHQQDLILMNCPIQQLQILLLDSFYECNHHRMMLNDGEYFLKTQSCCTDLTSMIGTQLELDNHHHHHTTAVDESSSSTSTTAIICHFIEFRQTPPTRSMSNCMSPVHYHNDGIGTQQSTATKLRRNSNHEDSHHHHHHHKQNFEYPSHLNPCYVYCDSPRMIQRIIQLVNEAKHLQEERKFEVSNLDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZA1</accession>
    <name>A0A922KZA1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZA1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="88" mass="9530" checksum="AA20BAF6F2725B1D" modified="2023-02-22" version="1">MNKNKNKISKTKTNSTTSGFSSISQSPSSSTSNSPGSSPTSTTERLLANEKKIKPSVANIGQHLSNRISAGYNISYFFQYISHVSLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZF3</accession>
    <name>A0A922KZF3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TCF4</name>
        <name evidence="8" type="ORF">DERF_011399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZF3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18943">
        <property type="entry name" value="bHLH_E-protein_E47-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000001">
        <property type="entry name" value="Putative transcription factor 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051098">
        <property type="entry name" value="NeuroDiff_E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11793:SF13">
        <property type="entry name" value="PROTEIN DAUGHTERLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="520"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="605"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="636"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9506680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="685" mass="74904" checksum="9321098F6A64A826" modified="2023-02-22" version="1">MKKVDKSQADMPSYTMPSYGSNGGQSQPQPTMANIVVDNVHLATMSHHHHHQDDINSAGIMGVVTTPTPSTYHQLNNPDHQQQQQSSQQPPSSQQSTHYPPPTNGTNSGAAAVANTATAPDSSQYYSPYCDSRGTLFGESSNNYYQLDASNDWNTAASQQYGSHIVGATQPPPPPQQQQYGINIHTHPQTMDQLVPQPPNTASLYDTVSSSPNNNNSLSSLPPMSTFATNRPNEMTTGDYPTTTTISSIQSPIQTIDIKPDITSLYPMTNNNEQQQQQQANQQWSQLTTSTQPPTRRSPTTVVTPLQQQQSFQSTDIKSSNTNEITHLHTMQTVNATNVIDDHHHQFDDPTNTTMHLMNDSNISGEHTRGVNVGERLDDAIDILRNHAEGQQLLGPNSFLSPPNNTELTTLEGHVQSPNGLISSMRTIVPQSTSATNSTLPQQQPVAVTSPLLHNAVAGTVSNAAPTSTSQNVKNKNSRSSSSSPAASKPKRSRGRKMLPFVSSADEDEPPEIKHERERERRQANNARERIRVRDINEAFKELGRMVVMHLKCDKAQTKLNILHQAVDVITNLEQQVRERNLNPKTACLKRREEEKSEETVHAKYMSNTQGQPPQMATTLSPPMMTGGGPGSNNPVTNVIQQQHITPQQSSNQSTVSAGPSNVSHSHHLMNAGASMSIVTSSNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZI5</accession>
    <name>A0A922KZI5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZI5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
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            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="507" mass="61007" checksum="66FA1B06C606AA12" modified="2023-02-22" version="1">MSGQFFISGTFFLFFLILFREKIKRLRNLSSSLLQYHANVSQYIVKRIFWNQFHFEYIILYGKISRLNESAKVILLAMEMIAKSAIMISCVFYSQQIKMVEANTFLVTIFIIVFLYVNIMYLRIAILPTYNEQCLRSILRWLIRSQWRHKFSDVQQNKQSTFYARIVQRIRWRQTLKSNLFIQATVNNRLGFTCGHMFHINKFKFTELIMLNIPYILMLYKHVTHYRHRTIPWNYSTFKMAIRIILNAWISMTFLTILGIRLNNRFIINIIFLFGTLILYRDGHIDLIQSIITIILVGLNMLTIWEKFGQIFIAMNFLLFLVEYIKIKLQQLSCLKQTVNGLQKNNPTVHIMMEWRKKLIWNRFQSRYVRYYAETIQLNGTVRIVLFYMEIISKICIMISCIFYSRQKHLGWSNTALILSLISEFFFVTGMIARSQWLRNKHRNRNNRSIHYWPYSIKSNLFVQTMTNNGFGFTCGRIFQITKYRYIELICWNIPIIIIFYKKICYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZL1</accession>
    <name>A0A922KZL1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4209 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZL1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025209">
        <property type="entry name" value="DUF4209"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039635">
        <property type="entry name" value="ERMARD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31701">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31701:SF2">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE-ASSOCIATED RNA DEGRADATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13910">
        <property type="entry name" value="DUF4209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4209" evidence="1">
        <location>
            <begin position="155"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="673" mass="80197" checksum="B39C101D851153E9" modified="2023-02-22" version="1">MHQTIVPIDQYHQSDTFLSNNVGNLFEKLFKIQSNDNQECLHPNLTIIDQYLDDFQVDFNQSFDSIDNVNRIGRFIRKIDSYFCPLLEHDDAIDEIQFSVRSNIEWCGPHWQTYILDAIDIGLRNEISAIPFTNPGQFICMNQILSLLLLTSGIEHCIGDVLRLKCRQIPPLMKDLIDMPELNELIGSDLIRPLKVLLGPPTTLNIRNILWHGFINCPVKQTSIEMRPFITTLIAIISTIGYRLSQHSESSIHSTDWIPRSPLYDLSEFANKHFPIVRDQSGDHYEQIFKCPLIHRTMRSAWAYMFHLQRQEKLHRRNQYWICLLFPLLESSMRYLYCHVNHLEDRRLLTAIARQYYVTFREIFGTLITDLDYWKIDTIEEQTLPRNRLLQFLPIGFIHAFNDLIIHCHGPHLRDRLSHGQIRFDHVDSNVVRFSADVTFEFIRWTTIHQMNDGQQCCSEKLSLLSYETQFHKIYYVRNRLITVIERLMIWQNQSSTSFNGIDLINRLRTIRPIDTGILYLSKCFTIVNFLENIVNLFENFFNILIQYLRQKQSLNQCQGRRLRSRQRENFQNFSHHFNHKYLKLICDNTWWSMMVMIMENLDQIIESGRFTNDDDDDSEWRQTVWEKRYQRKLQSNIQRLCKYSREHQWHRIEEILISNQAIAISITHDLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZT5</accession>
    <name>A0A922KZT5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZT5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9620" checksum="387CB87154905328" modified="2023-02-22" version="1">MIQFEFEMKLRNLISVIITYFFFSFHKIVVNLFFLLFFFVVVSNNCLLPLSSSSSSSSFWLIDLCSNEFVNDKQQQLFELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L040</accession>
    <name>A0A922L040_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L040"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="452" mass="48581" checksum="6AD24FA856355790" modified="2023-02-22" version="1">MQQQSRNQNDVVGSGVVDHDNCYSDDSNGLAQCNDHHHQNMDHDPISPQSMESTSKGSSNYMASNSPPTPPTTPQSANRSGLHRNSNNNNDNQQQQAAFTLKKYEFSPYAHLVSPIDKIEDGIDCIKDHQSVSPPTTTESTTSIIGLHNSNSYDNHLQHSVGGGNHNPHHQTNHHLVNDHHHSPGSNWSRLVESSHGPTSFYHPHHHHPHVGSEATSLISGNADSNTSNTLLGPSSNTAAVAAAAAATMIGQYGGAASTTTPFINNMSAYHPGSHGHQSWSRFVTDNHHHPYGHHHHYATTAETAANYAPPPPPPPAAPSSFHEYYVATTKRNNMTNYSASQIGNSSTGFITTTSTMATTTTPPETLNDHHHHHLAASSLWNSKASSPTTAAAAAAATNVYHCSKLDPSFETNVHQNSLLAMNSYRMMSSNPSSSITATITNTATPETINLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0X2</accession>
    <name>A0A922L0X2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COG1</name>
        <name evidence="8" type="ORF">DERF_010678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0X2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9505912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="788" mass="92818" checksum="4DBC8CD5F3373359" modified="2023-02-22" version="1">MESTNVDHLFRNYLVSDVILVQQKLKNDVEKKQNDLKQLIGERYNELFRATDSFGNMNSSINQLIGSLKKLSTTVLDNKDGQRPVIVEQKHEKFQLNANYFANATVCKFLFDLPLQIWNFLHQENFLLATYSSYYGDRIVQYLADQQSFQCSDICSQQLYSIHNLKSQIIRNCWQQIADQSLENEIDLDKFACKFSYLKILKNCSTNKIIEDFLNNQANNIDTIINETDRISILIQRILNITCNTIKCAKIFHHQSDSDEPQDCSLQNHLKEICKTNHVSELIQASHVQRIRWPEKLLFYTINDSIAIDLDEKFIFDKASLVQWIQTIKTRFYEKIEQKFKSVGSIRELFEEITSVEQWLMENSKLENLPIVDVNQSIWNGWFMAAFETRVYEITEIELKYIQTTFITSLPMIEQNLLNCELNIVEFVWKEPNQPQRINDFNGLVQKTCDMINQRLSIFYEDIIIFKRSHQTFLIRIYSSIAEFLRSLQIQIDSVNDKRQKSLLLFCAVLFQRIPDLCPSISQIFSICDQQQTNGLSWKQISSELRQMNESYLQNLFDLTITEHFSRIDPTSFVDLSQFLKNFSLWETITISNDQEDQSKTIIEVPIQLSLETYQVLHDISNDINRFCAHMVTRQVLINILHLIGRHIMKLYGDALKLLAKLMDPVLKSPKQIISIQLYFDLFFLKKLFIQTKHDDQLRREYLEPINALMAELESNIDPFDMHLIHPHIESNVYRLQKSYQITFGFLLFERTMNNSNPKEWLNKENVHNLMLIHSCNGEDFKTMLLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L116</accession>
    <name>A0A922L116_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L116"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="8104" checksum="051D87A81A17D8A0" modified="2023-02-22" version="1">MAMYAGGGGGGGDTFYNFNPAISYRIENEIASLILPFLISPMLCKLYWIIPSWNINFNIAGHSKCMHSAYQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L260</accession>
    <name>A0A922L260_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SMPD2</name>
        <name evidence="17" type="ORF">DERF_013277</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L260"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="16">
        <location>
            <begin position="15"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9497280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="600" mass="69026" checksum="C4E7E43F7803E3DF" modified="2023-02-22" version="1">MSAKKLEIDNLKIFTLNCWGLRYVSDHRQVRIKLIAQHLVDQDYDVVFLQEVWIQSDFEYIRTKTKSKYRFAHMFNNASLLGTSGLVIMAKWTPQFIHFHPYSINGSPFRPFHGDWFSTKGVAYVRIELLGLNLHLFSTHMHAQYDLNEKIIDQYSIHRICQAYELGKFINLMSCNCTNTGSKDLIILAGDMNTSSKELPYKMLIELTDLNDCYKLLQIDQQQKRSLKCNNNNNNNSMDLTTKTSTPNKRINKMKIQESSIDHESSDEELTTCGHRDNTFTPQQNLKPDEKAGKRIDFIFFKLRDSCSPSVSDHHRILHNRLNDNGISTMDILKNNMETILPNDVIPSNNNLIETTPFLMCLPEKMNIVAKDITGLSFSDHQPVVAKLHFTWKTIQDIVNESKDLGNNHHHSDNKQFMNNNMDEELNSSLIETTIGSSSSSSSSSSTISSLSAAMKTTTNDIKCLTSSKLISKFRRKECYLALREHQPMYKKIKDSALIQEIETLLTTYVDKFRPSFNYTLITVLVMVIMFILILMLFKFIISLTIIETILMSLIIMIIASIGLLLKFITHRTEINAIKAILNDIQRKKTFHPDYGLCNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L353</accession>
    <name>A0A922L353_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L353"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="125" mass="14673" checksum="D5AE27A821114608" modified="2023-02-22" version="1">MKNHNLDRPEQHVFDKTYITDYQIALIYNPRHWSQARTNNFSGTLLSLFYYIHEFALSSKVSIDVDSSYIVGLIRFLFVRSLFLISANFVIDYHLIRPKFDDAFPLSPCEVLFKKIEKLAFTAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L396</accession>
    <name>A0A922L396_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L396"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="138" mass="15053" checksum="CA5800D16209BD2A" modified="2023-02-22" version="1">MLLPSLNSCVNPWIYIYFNPNLITLFCQFFKRKSSSDEPLSKSGALLNNTACGAGGGVGGGSGSGSGLNAKFYTKRHHQTSESPECSLSMTDNTTLSRSPRILSRNNNNNNNDNNNMMIVDMNKPGAGFRYMATNLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L557</accession>
    <name>A0A922L557_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Neuropeptide Y receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GPR83_6</name>
        <name evidence="13" type="ORF">DERF_011828</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L557"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="287"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="585"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9507129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="770" mass="89191" checksum="1F9E8741D4D73AB6" modified="2023-02-22" version="1">MVITTNKLINNYGTCAILVPTTKMTNGAAISLANTSTNTTTTSSNTNRIDVGNGNYKESMVTYNIRCRLFNVHDGRNDTFVNSKNFRKKRNLLNNQQQQQQRQRQQQTTTNLIEHLGNLLKKFHQQQRLLRTSDNQSIKTLSSSSSSSSSSIENQYKTNEMSIINGQQVFVDHIHKMSTILPLSLLSISTAATTTTTTIAYPLFDYPHHNHQYSLKNHHIKSLSSENNGHIDDGIQNFENNNSTLNELYANEIIRLAMEFNRQRPLSIRDCSVIIMYGLIVLVSLFGNLLVCKVILFKQAMRRRITHIFIANLTISDLLMTIFTIPMNTARQILDDWPFGEFCCKLVPFVQAISVYVSALSMTMIAIDRYQALVRPLQPRLIQRLPRWIWITSIWLFASLISIPFAIFNHVVNVLTIHPYIPFGNNEKLFRCKALYPGNDPEYYQRLITCLAFVTQFCIPMIIVAYCYITIGMKISKRSCIGETIDGGQQTYLKQKRKTIKMLIFVVATFAICWLPYNLLFIVEDFFHINFSLTIHYLIHWLAMSSICYNPFIYFWLNRGYRQGILNILKYCYCCRYYHRHHHHHHDHHNDHHQHRNSATNNENNENENRINNTDYVNDPFSEMDTINMQINHNHHHNQNEIIITNKQQQKQQQNLKCENESNPIIISNGNGNDNGNHRRDENAIATTPATTMTLPPSKTIIKLTKKPMSLKQTIVRIIPSNNNHHNVKNNNKMSITMTEITSLKHCNQNDDHHYCDDDNDNDDDDENCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5M6</accession>
    <name>A0A922L5M6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein gpi1 isoform x1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004538</name>
        <name evidence="2" type="ORF">HUG17_0615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5M6"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7645077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="659" mass="77661" checksum="A90816E892A2C4D7" modified="2023-02-22" version="1">MDPLQWINIFMSDRLMVNNVDHSNDDGGLLVFGHYERSIDGHGLNVNITATLRQRFNSSIKQSLMKNDEIDNLVCLGQINILNDCSNLTDHINNGDDNEMQMFGSVYLQLTMRQSTNSNNNYDDDQSLPYHLKSIRFMGKQFMNLDKVSIILYDAYRLMRCQSFDLYTPGNRIEFLNFVLKSLYDTSILYENGYHPKWSTKNDNNDALNDNDIYYDYMIARQLSTTFIYYYGQAKRYNNQKSAICDDFATTLTSEQSRSSLRLPYFILYLFWLLDLLTFHKSLFIAQLKFRLLQIRYILNLAKQSPNKQSLSLCNLLFAIIFDHILGVMAILLVFRYTNHSHLMQLVHTNVGLLLNKIYNLLLLLQSMPAGLKLNHPFNQALSQVMFYLIYLWQNYMLIFQKLFPAMTIFACYFGIFGITFTISLLSDLFKMITVHIFLFYGYTSRVYNFQTAGIISLWRLFRGKKYNPLRDRIDSYSYENVHLFIGTILFTVFIFLLPTVLMYYVVMLIFQLIIIAIKQSLFFFIDFLSTLPLYTGWLWLINSNIVSGRIYFRRMITNNNTSKRHESEISNHRKPAIFRMETLPDSFMNLFNGHSDFVARQLKQFLLNNSYRNVPLFKWSTFFGDVILGRNVGENLPYWFSFLLMSISLFLFYQFLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L732</accession>
    <name>A0A922L732_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L732"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="286" mass="32966" checksum="72FAE29BBA121D31" modified="2023-02-22" version="1">MVKFIDNFPVIKLKIFQFLSNMKRSSPLVLMFLSLSLITMAMALNDDNDHRSFTIKFDKESTISKNRNDNGEKIENSSATAAFPIKIISFKVKRPPTPPPYVSGSNSNDLIKIKIINHESRYMKRLTYQMIQWIMRQRRRQQQQQQQQRNDYRMQPKLKISNVNINRIYPSSSSPPPPPPRKNDCPNCRYRRQNVNQNSGCGDGYGDCKKQKPQYQLSGCGDGYGDCKKQKPQYQLSGCGDGFGDCKKQKPQYQISGCGDGFGDCKKQKPQYQIPDDDYIENLNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8E3</accession>
    <name>A0A922L8E3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NPC2_2</name>
        <name evidence="8" type="ORF">DERF_001154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8E3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00918">
        <property type="entry name" value="Der-p2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF68">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037273418" evidence="6">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="7">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9527111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="146" mass="15784" checksum="E10A8206C838434A" modified="2023-02-22" version="1">MISKILCLSLLVAAVVADQVDVKDCANNEIKKVMVDGCHGSDPCIIHRGKPFTLEALFDANQNTKTAKIEIKASLDGLEIDVPGIDTNACHFVKCPLVKGQQYDIKYTWNVPKIAPKSENVVVTVKLIGDNGVLACAIATHAKIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8J0</accession>
    <name>A0A922L8J0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">E3 ubiquitin protein ligase rin2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RIN2</name>
        <name evidence="8" type="ORF">DERF_000644</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RIN (Ras interaction/interference) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01776">
        <property type="entry name" value="RA_Rin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23268">
        <property type="entry name" value="RIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="966"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="7">
        <location>
            <begin position="1963"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="6">
        <location>
            <begin position="2163"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="729"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="898"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1259"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1501"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1690"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1789"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="531"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="867"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="917"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1141"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1152"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1186"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1218"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1259"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1271"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1515"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1795"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1817"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1831"/>
            <end position="1842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9526569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2262" mass="253064" checksum="C78C9AA7ACB77D43" modified="2023-02-22" version="1">MSHADKTADVNHPPSSSTTNNYRPPQPPPPPPPPRSVFHYWKHSSQQQQQKEKQLKKYSSSLDETTLNICGNSGGYNKHSNQRNIVNRRPITVQRNDNFEIFYSSSSSSSDENDQNLNHHSINHNQHQRKHHSLSDNPRSSRNQQPRNIRHRSKFCYQINPSTTTVTNTKEKNIENSNQTLHSELLPREPSTSSSSSSSDSESSSSSLSSSTSTSTSTSSLSEASFDLDQIESAIIQQQPITESIYRQQPHKEQHTNNLNRFTFSSISANSFPSSSSNQRQQNYKQQQQQQKTPRNSSTFWDLITDVAKDLDLKLQDLSPDSEIFEQPAAHTNGGNGGGTITKTKKLSSINSKQKTIGISKNDNVFRIVNESKQSPSTGAEIANTTDNNDIINGCTIKTDTYHQNDNIDESKSSTNNNIIIINEMQQQQQFQFIDQITESSSSSSDKNIFNVIIINNEQQQRQQQQSPPSPPSPFANRTQQKHCIIQQQSATSSPAPAPTPPEPYNDYQIDNRQKQQQPKQKQKQHRIVGSSSTSDYQSTKSSTSKITDNNQQQQQQQQQNSFFNTTIQQQQQQLKSSDIVTAAAAAAFIANDGNGGGGGGSFSSTKKPSINVATIDDKMMMIDRFKKSSVSFSLSSTTSTSTPPKMVTSMKKILNKKNLTKNKSKPISSINRLPMNNTFTTFISNSNIPITNPNDSSGFQLALDKETLSMTTETSELTKPNIVVKQMSLSHNKNNDNDDRKSDDNYDQHENDTTTATTVDVLALLPEGNVDDDDELDHEEEDDDDDDDDDDGREIAYEVDADDEQSNDMLDDNTDDEEEDEDDDGPKSTSPGPVAAGSIVTKIDPSTKSMVQVISIMKNHSHTHQQKNQNQQQQQQQPKTITSFINQKMLKDEIMRPAESEDSAADVSYERTSDLAESDDLEGEEEEEDATTTTLTTVDTNNVNNLDSVKELSYDQRFRMTQTIWYLPHINRATVVHYLQGKNVGVFIVRQSSKPNTMAVSVRLPQGRGPHVEHYLIEKITKAPVSSSTTKSSSTSSVFRLEGSEHYFNSILQLVIHYSQCQDELPVQLNLPSVLLNSGRSQLTSLALLGQEFWQSKFVSLKQLPKNSLNNETLAMINQNQNQQQEPPPQQQQQQQPTKHYNRQKARRHNSNSSESNQSKSSMSMSPMPPPSISIRSRRNTSDSASPTTMPSQSNAVSPTPPPLPPKNLSMTCGGDHQSNSPLMMINPTKTINEDSISSPITATANTTTIVEVHNNPTIKNHNHQNNLPKLPPRIPNYVPPPIPPRNRNSPNGGGSTTPPPLPANGPPLSSLRTKKPYQSNQQSKPAALQDLLSPMSMTESEIEMAKFSLTHKITPNILEVEEYNDDDDEISNNLSLQYRNYYNQMIQAPQHHHTSSLSPVPIMIGEEEIKNQQTPSPAPLPPQHSLAAVTELQPSIDAQQPPPPPSSSIKCDVCTQTYDTNKQLLLTPNQSQMGRITRANSSLSCFYMDPIDALVAIHQQHQQPKRHSDPELASNSQNTMDMESSSLNPTTFTMSHSLESLLENFRNRFATAVSGSDLNSIRETLMNERRNQFIHHHHHQQQNQGLKSFNPKHDTAFSTLDSAWQWHSGIGGGDQCHHNGRIHRSIQNQLAMKMSLAQLEHLKRSSITTNGSMKSDITTVEDLISAKAPELAVPKITHIDSMNLINKKHRQQQQPLQQDSSDRERKLTAKSVATDVCTEFSEPWNMDVVESLFISELHHGGGQSSTNHCGLDLDDDDSTNSTRQLLNNDLINFNSFLLNQEQHPHGLVVPQTNEDDYDSVAEDESDEQTLNGHFIKRDDSEITLKEKNPQQPRNSSSSTDDGIKLNIAYNISNYVFELAARKDNTFAKSIDNFIECTKETTDPNPSVILGYVRQFMNGMKNYLIKHGEGDFIKIVQNERSRLKPNQFLNIDSILEVSLQKLIIKPLKNFLYELFIRSHTMSGSLKILSTNIKLAQNKTPEELGIRTELLPIDPRIMAEIQKNLRRLQQSYSPIKKLEHLLRCIAILNGNYKEKITSKCSSDKQSKYNRAFSGDDLLPMLVYLIVHCGVISAEIESEYMLGLLHPSILNGEADNARALEDIITLNGVGGGGQSMFSMLKAQPSENLQRQMNSSTTNGGGAMISSGSTCAPLALPSIANMQAYMKIMIPNELTSSITCKTVPVRHNMTTKEVCRMIAHTFRITNPEDYSLYRIKENGLEEIQLLDNEYPQVIKSELMARNESTMFAYKRCDAKFIWPITSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L956</accession>
    <name>A0A922L956_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparaginyl-tRNA synthetase, cytoplasmic (Asparagine--tRNA ligase) (AsnRS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SYN3</name>
        <name evidence="8" type="ORF">DERF_000941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synapsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L956"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000008">
        <property type="entry name" value="Synapsin III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000059">
        <property type="entry name" value="Synapsin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001359">
        <property type="entry name" value="Synapsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020898">
        <property type="entry name" value="Synapsin_ATP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020897">
        <property type="entry name" value="Synapsin_pre-ATP-grasp_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10841">
        <property type="entry name" value="SYNAPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10841:SF17">
        <property type="entry name" value="SYNAPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02078">
        <property type="entry name" value="Synapsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02750">
        <property type="entry name" value="Synapsin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01368">
        <property type="entry name" value="SYNAPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Synapsin pre-ATP-grasp" evidence="6">
        <location>
            <begin position="69"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Synapsin ATP-binding" evidence="7">
        <location>
            <begin position="173"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9526883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="560" mass="61876" checksum="7C093CDECC6A0D96" modified="2023-02-22" version="1">MILNFKSSNITSAPVSPHSTATNVTNVPSARGVSGLLSRATSLTGSNIVTNTVQQIARAATSQVAAVIKDRHKILLIIDDHLVDWSKYFRGRRLIGDWDIKVEQAEFKDINLSSDSELGALVTIYTVDRNGFRIARTFRPDFVLIRQHIQQDGNQNYSDIIVGLKYGLIPSINSLQSFYNFQDKAWVFANLLAIQRKQGKESFPLIEQTFFQKYKDSSGVPKLPCVVKIGSSSSGLGKVKVENINQYQDIRSVLMITNKYCTIEPFIDAKCDFNLQKIGTNYKAFTRKSVSGNWKANIGSALLEPIPFNDRYRKWIDDVSDLFGGLDICSLEGVIGKDGREFIFKVRGSDMALLGDTQEEDRKNIVELIIQRMNAICKNILIKQQSRASISANEPESIEQQSKRSSITSMNQPTSAAVPPPIMNRRSSKDSSFPPSSGNRPLPPKPPPPTSSSFAANPPSKPPPPPPPPSSSSTHSSNTVPSSVATTTSTTKTINENPTNPFASSFNPNAINNDENEQMTKQPPPLNKRDSQTTIGEIKEEVDDTMRNLRKTFAGIFGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAI8</accession>
    <name>A0A922LAI8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAI8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="49" mass="5790" checksum="8EDB21AEF53E05B5" modified="2023-02-22" version="1">MEPDPCWWTNDAYWSYRYLIAFRLNLFIMITLIMDTTTTSIATSSSNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBC9</accession>
    <name>A0A922LBC9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">ATG8</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Gamma-aminobutyric acid receptor-associated protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_003246</name>
        <name evidence="11" type="ORF">HUG17_5249</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBC9"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000037">
        <property type="entry name" value="Gamma-aminobutyric acid receptor-associated protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7642204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9529357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9529358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="117" mass="14049" checksum="6B8E14E4E29D811A" modified="2023-02-22" version="1">MKFQYKEQHPFQQRKEEGEKIRKKYPTRVPVIVEKASGARIGDLDKKKYLVPTDLTVGQFYFLIRKRIQLRPEEAIFFFIHNMVPPTSSTMGSLYNQYRDEDFFLYVHYSDENVYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBL7</accession>
    <name>A0A922LBL7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBL7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7296" checksum="0E8E01C7CB9D2634" modified="2023-02-22" version="1">MLFLIQLSHPNHRNCPYLYQNIHEILMLYDVLASNDICSAQSFNIPDDFSWEILLLLALTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCH9</accession>
    <name>A0A922LCH9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ sub B member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DNAJB5</name>
        <name evidence="4" type="ORF">DERF_000516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCH9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000026">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9526420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="376" mass="42379" checksum="1E48244C829CA41C" modified="2023-02-22" version="1">MSVSIYGVLFIIEIPIHCKRFYQTKPPLKYHPDKNKSPEAEEKFKLIAEAYEVLSDKKKRDIYDQFGEEGLRNDGGMSSSGGFNSNGNAANNFTYTFHGDPRATFAQFFGTDNPFDIFFNFGGLGGNSHSVHHHHHHHPSSFIGPGFSFFNGFDDMDDSFFSFGGGPGRSSNAFRSQSFTHGSPGNERKQPRKQDPPIEHDLYLSLEEILNGCVKKMKISRKILQQDGKTYKKEDKVLTINVMPGWKAGTKVTFQREGDHSSSSIPADIVFIIRDKPHPHFKRDGSNIIYTAKVYLRDALCGCKIKVPTLSGVTIPIQMKEVIKPTTQKRIPGEGLPFQKDTNKRGDLIVNFDIKFPDHLNEPTRQILYDCLPAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCW1</accession>
    <name>A0A922LCW1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCW1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="724" mass="84624" checksum="F5D335DEF539802A" modified="2023-02-22" version="1">MIGHYYQSFAMLQREIHDYNQQLKRYLSVIFTLITVTITYIHMGTFVTLSVLIIGCNMIKQNNVKHCDYNFETITSIQLNQPSGFQLGNGVTITSYTFVTFLVNIKIKLWKKLMKFHYYRKFHNQFFYIYFYDELLQKQIIENNYPIDKKPIGKIMNPPHHHPIFFIPLVVVMFIAYSYMYLFEWVKNYQFDRAYIGLLPKDGINYLMVTAILWGINALFNGFYASSRYYQHFHFLLPILHQRYCELNTNDSNKYALIRNCLLSLIRIGSSIMCILLVLGIITMSIQHSTWQISIFWSFTWIFTLLLYSIHVVAAIYHISSIIFLAQYYLNLRQKSHGRTLQRFYGQLSRYERKQRIHQNSRQFLFGKIIEYYYQSFAMLQREIRDFNQQLKRYLSCISITIHCDSKCTLYVIISIDHWLQYDRKNNVKTLRLQRKCLTLSSTCKRKLFHNYQLFKFETITSIQMNQPSGFELGNGVIITSYTFVTFLVNISSFFFLISQVHSVPDISTQISGTRISTFDFGNIRYQFGNLEYDKELAVESGAAMAQLRHPTRLATIASSEDGRQSMTVTTSATDLRVIRHATNYENGHDHEESSCTRYLLDSSEYDGELAEESGAVTARLRHPTRLATIALSEGMRQSMTVATIATDLWSRQSTKVATIAQVPRRTRTFHRSGDDRIAMDIRQTRKVATIALNQWRHSTRLATIAPSENGRQSMTEATIALNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCW6</accession>
    <name>A0A922LCW6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCW6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037737496" description="DUF19 domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9530322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28834" checksum="A7C3BFF7D2CEA630" modified="2023-02-22" version="1">MVRFVYPKMFHIINIIIVFDFSLLIIDTATGNNNNNNNIRCDRFDDMFNDFTMVSSNRRQFPTTIDEFVKYCNDLANQIAQSIKQCFNDSSMRNIASLVLYSYRSRTKSLCKNRNSKRAREYRDAAPCLNQYKHRLSRCIDITANKIGAIQSRPNNLKFPHLCWYVDFENLQFQRCIDKISAGDCKQKIMVFAESAQSIMNGFIDRSCGEYNADTDRCDQLEPIVTAELNKSSKPSFVRNVAELISSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDI5</accession>
    <name>A0A922LDI5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDI5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="7365" checksum="8E949477F3CC4DED" modified="2023-02-22" version="1">MYLSDPKDREHNFLADKTKQNKNKNYDALIAKQTFFLWCFTCNFTWRQIIIDHRVLIELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HH90</accession>
    <name>A0A922HH90_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HH90"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="117" mass="12560" checksum="6473959BC2D296C5" modified="2023-02-22" version="1">MHGRLRTIAWSTTSGIRVWSAGSRIHSGSSAGSRIGQYTTICSDQRYSSLVDGDCLATCVQFNASCCSDCIFDDADVAFVVALGDFNRFANQIQIVAITTRSLKTLSGHWRTATGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HIT9</accession>
    <name>A0A922HIT9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HIT9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="96" mass="11049" checksum="263A2379A1861AC6" modified="2023-02-22" version="1">MSILIYPTMAINVSILTKIHNSKESKSTELNILTNHKFQSKRSEDKPNQIMKITAKKGGRSLLHYWHYHNEISNNNHDPGTGLGSSFSKSIHIYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HK31</accession>
    <name>A0A922HK31_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HK31"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="50" mass="5675" checksum="79EA134AF45E8000" modified="2023-02-22" version="1">MGTTGRFGGGGHGLTGPKHIWLNTFELYSTSLFIEKIVVVELIKFENYEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKB3</accession>
    <name>A0A922HKB3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKB3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7934" checksum="3CCF869E87AE0C4C" modified="2023-02-22" version="1">MIDDDDMNVEKIKFTFQSKTELKRLDFEVFFIVIIFLNYHSVKKNLKKRFCKYDFSIFSSNFSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLP2</accession>
    <name>A0A922HLP2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">TATA-binding protein-associated factor 172</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_013232</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001793">
        <property type="entry name" value="TATA-binding protein-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1370"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1769"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1060"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1668"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1938"/>
            <end position="1958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1060"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1668"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1684"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1941"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9497227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2001" mass="226884" checksum="252F465ABE96E56C" modified="2023-02-22" version="1" fragment="single">NQQTNKTKTMASRLDRLFLLLDNGSTPLTRKAAALQLGEVQKLHPHELNTLLVKVRQYLHSSSWETRIAASQAVEAIISNVPNWFPIGSLLSTNDDNDEQNDANDDECRMRFDRYDIMTVIKCGHNLLASEGKDFDAPTADSSSSSNTVVVAADATLDSREKIAQMRQSLNQKLGLSFAEKIGLKMDFISNADLIATADVESKPIVEKNLKLEQIIPNVKTSSSIVKRKTSPDIKIENSNDPSMAKKIKLESVDDENSNEQQQRQQQQQIDNNNIFDGDEWPLAWFSDELMSDLFNAQWEIRHGAAIGLREIVKLQGRCGGRIRTASLSRQDALNQQWLEDLSLRLLSVLALDRFGDFLSDQVVAPVRETCAQVLGLIIKLLSTNGVHNVLAILLQLLQCNEWEARHGGMLGLKYLLAIRQDMIEQLLPKVFEPIFAGLKDPEDDVSAVAAAALVPIKDQLMCLMPEKVPLVIAFLWEALLVLDDLSSSTGDLLMLLSSLLTFKGLTTTDFKTDNNDQQLAILIPRLWPFLSHSLSSVRRSVLESLLILSEKNSNEWLNQSSLLSDALRLLYQRSLIENHTIILDLLYKVWLNLISKANYQCLIESTRNYVTSWICLMMQPQKMPIDVCNTPVWLEIKHITHSLPSSSASHLKNSRPSTSQQQQQLLSSLPAENYFIGGSESLGETSEERERCAIRARYQCARLIGALAFYLTEENGTPSLNGAEQSNVESSTIIQNPLDSFASLLLIHLNTKSAIQRMCSAWIIREWATAKVNRQGEQQPPWIITMKNDDNDVEEYGVDQKRNSLQLHKGLADRCNESLEEQIFFDEISAYVSRVQYNFRDLLATTRTNKVQFNDTELAGKTVYTFPQINSVIDNIQHRSLMEMRQKLIEIRKPNDKLKSLIECLEEKISLTRLTITELNQLTNSLSIGVKSSLASALIEWRFLPDRLSPIIKPVMDSIKQEDNEQLQRGSASSLVKLLNIFRERTYLNSVQSTPTAKIINNLITYLCSDRNFTPEVRLSIDNDNSDDKTKRSDAQYGILALDNMQKIAELNIALRRSNSMNMKNRNNQNQPLDDSNNGNNNGTSTIMNEQQQEKQGEIQRRGATIALSETCRAFGQYLPEQLPSLWEYIAKISLESQSPPAFDENGLKSCRDLIQSLQVFEIIGPYLHQQLHSSLKATFNFLGECLQNPYITVRHMAARCFGMLSSINLNVTMDYVLTKVLDMLEASDSELKRQGSVETIYFIIYRLSLKIVPYIVLLIVPMLGRMSDQNESVRLLATHCFAQLVQLMPLDNDHHNHHQQKNNSIKMNALLLNNENLHFSDELLRRKENERHFLEQLMNIKKLDDYPLPIPVQAELRQYQQDGVNWLAFLNKYKLHGIVADEMGLGKTLQAICILASDQYYMKQRFINGESQNKPLLSLVICPPTLTGHWMYEVEKFVDEKYLNPIMYHGPPFERAKIKQQIERAQHRIGAAATTTTTKSERTKNHHNLIIASYDLVRNDIDFFSAINWNYCILDEGHVIKNGKTKLARSIKTLRANHRLILTGTPIQNNVLELWSLFDFLMPGFLGTERQFMSRYSKPILASRDAKSSSKEQEAGVLAMESLHRQVLPFILRRMKEDVLKDLPPKIMQDYYCELSPLQAQLYEDFYKSRARQTIKDNLVDKVQELSSSSTTSTNAKDARLSSSSSSSSSSMDISKSHIFQSLQYLRKVCNHPKLVLTSTHPNYEKIMAKLKSEHTTLADINHAAKLIALKQLLQDCGIGVSQTTGQDQTAAEPVVNQHRALIFCQLKSMLNIVEKDLLKTHMPSVTYLRLDGDVPAASRYSVIHRFNNDPSIDVLLLTIQVGGLGLNLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRYKRKIMGLQKFKLTIANTVISNENSSLDSMATDQLLDLFELTTTGNEKKELANNNRNGNSTTSKEYAITGGSSGQVSMKMMLETLPELWDTQQYENEYDLNNFLQSLSNFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLV1</accession>
    <name>A0A922HLV1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear condensin complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_016015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLV1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="627"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="987"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1045"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9491286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1069" mass="125901" checksum="9A360721F95909C1" modified="2023-02-22" version="1" fragment="single">MAQNSINCNVESLRNELAKIFNESQHLKNSKKNVKEFMKIYKSWFIDNENFENFMATFIEIMKNVLVCNNSSPYTKRALDFIALIFKEIIFFEEEYERKRIDNVIARGDETINSEINNDASDFDDEIGEECFDRDKTIIDTRFISEPTTVDLFIRNYLLKFIKADDVFVRRNSVLLLRKTIDSLEEVDENTFAEVLKELRKRSIDKDKCVRSLIMLCLRKLQNINNDDNDDDEAIKILKFHLQYDPDSFVRSVAMKTIGLYSNTIEVIYNATRDIDDVVRRLAYLKIAENSCANNFSANDRLQLLINGHTDPSNQINNIIIKKLLPTWISDVNDDIIRFLEYFDIRNETDFFNTLLDDYFQSLLKIVERDDITEFHQLVFRFKQKCMNEHKFPSIILPKEECVYLWYRLCNFSKENNITYKKSMPISQNNDYDDDNANGELSQRQNFIINDLLDDIFPDIPVYCDYIESFVNNTISLHSQQKNDDQSQSSKIVFRHKELNFIFQQSLNIGKLYKISDTAQWNRIERTFRSIILNDDLYTMLNDYIEPIFIIFNNYFQNDWQQLLELALDLINTINLPELHCDRIQTQSQSQPMNSDYQSQTNEQQLIPSSQLNPQERIETDPKILERCINICNSFLHVGGPKNCDTLSSLRGLVNKLVLRNLAHPESEKIRLLSVKALGNYCFQSVVTINSFLKVFIEILKEENYLDARVEALKYIFDFVGFYGLRKINFVDSDNSSIRNQSNSMNNSHDVSNRYENFFEFFSEMLLDFLVEPSMEPAIMKKRPKTRIEYDLFDIAVRGLCKILYIGRFSSSDFLAKLMIIFITYKNITTDTKYFLRIFFHRYSENIEAFFDHFKTKNSPFNDAYVQCFKMLMENDVTNLNSYEMVVDMVDACTNDDQRNNLVSKAMEIFTLTSEKDLIHLNLKFIDRIIDYKCIEKLDLLDLIKQFDEYRQRYQRNNNTVRSRQDKCILLFKKIIQNLQLASQGKNQSIVENDDENNPRTQRSLSSITTTPIQQQQRKRHSIENVNTNQEIDVTIVDDNNVANGDDDDDNHGISDLDDDDEDNDYNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMG0</accession>
    <name>A0A922HMG0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 181-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_013499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMG0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040416">
        <property type="entry name" value="TMEM181"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054077">
        <property type="entry name" value="TMEM181_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21885">
        <property type="entry name" value="TMEM181_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM181 GOLD" evidence="7">
        <location>
            <begin position="100"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="6">
        <location>
            <begin position="216"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9497511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="64418" checksum="9E2A50AA1B10056A" modified="2023-02-22" version="1">MSFLYKARLQVNDMFSQFNRFIAPMYYHDRCERTLQMYVYVMHKREVLLSLSALLSAYILLLFIGLAGPNVDKINSVMAKEMISESNIQENYTAQLLSYGPFVVITPALSTYSQQLSLHLTFSLKNEESSEAFHKEFDILIDLDGISSNNNKTLLSRGRLKSSLYCGGRKCEPIRVIRLIEIQFQHYRINLTFNRLQSVNEKYTIDDILFEFRSVNISFTKLSIWFRFFFLMVTFMVMCFYMHHLYRFSIIDWSLEQKWTAAQLLLLILSNNPFYPIQFLLGSEFPYLLEVWLHTSLQTLIMFFWLCFFHGIRQNNRSLSRFYGGKLVIIGTIWFTVIYTMSWSLRNQISNPILDELYVFNHSIFLQLLSVFFHIAFVLYFLYLIILVMAAFSELRLMPYFDVRLKLQTFLMLFVITISMLTILISTTSNPSTTNMISSIPFLRLLPFTHFSSSSATFLSIFSLVNIYICSCAYYYRPSLNQSNECHIVRDNPTLSMINDSDEEVLYGSDTEELLSIQANNHQQNDHSNCNNLNNIVPNLIDTRTDEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMK3</accession>
    <name>A0A922HMK3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_015780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMK3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9491043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="158" mass="18261" checksum="A21089B072985C2B" modified="2023-02-22" version="1">MITSTNRPSLSSPPPQVPLLLLSSSSSHSTSPIQMMTSNLKCPPPSPPLQPPMPTMMTSIIHDPHYHHHHHYYHHQQQQQQQQQQQQQQQQQHHQSAYRSSPTPSSSSSLSMDRAAFLLIRIKRVFQKKKRKKQTNQKKEEKISLIEKKGYNTHIHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMR5</accession>
    <name>A0A922HMR5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LIM domain only protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LMO7</name>
        <name evidence="7" type="ORF">DERF_013648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMR5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032034">
        <property type="term" value="F:myosin II head/neck binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15551:SF3">
        <property type="entry name" value="LIM AND CALPONIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15551">
        <property type="entry name" value="LIM DOMAIN ONLY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="929"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="889"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="451"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9497682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1002" mass="112652" checksum="A6E79343BED0A38B" modified="2023-02-22" version="1">MLTMSHNASERGSWKESYRSSDSVESSEDSDNSSTNSSLNGSSNRQNSNSHLPPPIGCITTHRVSAVIRPEIKIPPIDPLQFVKIQKNELSKTAVEQIKLAEEEKITKEKIKEVEEEWQNNLMSWKSKRKLTKNHSEDEALPRNPNRKTKTFSEILNEKAKSGARIGYNLHKYIDPDLEDDFNNSQITEFMSTKEEYLDEMTKTNGESNVSRPNMESSRSKNSNSTVNEQSKTKTNLDRFMEMNNSTDDMNMDKMSRNGLGEVVVFNTSLLEEFSVKSEQQQQCDIQQQQKPNKSSNIDKDDHHSKGIQKASPYSVTDSGKNDSPVHSDKKVHVPINDWKSSHQNLQQQQLARKYSSSNEDDVPNTQNSSFEIDDEEELDEELEKLRIDQERSFKAKLHTFEILAKQEEEAARRAAEANLKRQQNRAKLAAERSKSLSNINSQPKHGLAASSSVSSSSLQNKNANNNGNNDSSIKKSANNNKPIQNVNKPVNNINNNNEDHYYLTCKNQPTNSVVYNFKEKLETNTLTTIDQPQPQSSSSPTITATTKATIGQKSSQPLKIQTPKTQSSQPNQAMKMNEQPVINNKTTMNDSVERSQREQSSMNNIYENVPSLATNQHQHPTQLIHSNTASSYVHQQPPNVQSQTILSNEIIADPDAIRNASQKLLQQQQQIYQNQPPLQTTTTTTSIKHPSMVAPYPNDHYSNITSLHGNFDSSSKHEFLMDNKIPMTTGKTGSYLHTISDDVGLPPIQITKSIQTTMPPASDDHHPVYQNQIITTSQTFHNYENSPETMMLPARDDLVSFYPPPEPIFQTQPQPSHYPLNPLYVNSQYLYYPKPYLGSTGNAHMMKPVPVSKQSTMPNNATRLPTTSRYGANGYNPNHWVIQEAELRQSTQRMHQPPPPPPPSSSQVSNMAANNKNCPGYLSVSGKKKCSKCGDELGKGCAAMVVESLSLYYHINCFRCSVCNIQLGNGTVGTDVRVRNNKLHCQNCYSNDEAGLKFSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMT4</accession>
    <name>A0A922HMT4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMT4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="272" mass="28385" checksum="8D2A4E8FF8DC2A2F" modified="2023-02-22" version="1">MVCDERAKFAIDTYDCNAAASAEPGDVPDPIGILATAVRTFALANAANCLLISANAGYLLQMSHFHLLPTQLPPEAAAALLPPPPPPEADADDVDDDDGTLDERTLLLCFFGGTISTVVPAATETAFEFGNFIRLLFSLFIRLLSFPLVEPVEYGGLNVRRLFCCDEDDCDDDDCGCVCCNGDENDGIIVGSASTSIIHGTCGANGDGTIDPNACAECMLVGNFCLRLLPPPDDEIEEFDESKRLFTEGGGGGGGGTILLLNKANAAAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN55</accession>
    <name>A0A922HN55_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">N-terminal methionine N(alpha)-acetyltransferase NatC</fullName>
            <ecNumber evidence="13">2.3.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N-acetyltransferase MAK3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NatC catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NAA30</name>
        <name evidence="18" type="ORF">DERF_013867</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-isoleucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50524"/>
            <dbReference type="Rhea" id="RHEA-COMP:12713"/>
            <dbReference type="Rhea" id="RHEA-COMP:12714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133379"/>
            <dbReference type="ChEBI" id="CHEBI:133380"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-tryptophyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12724"/>
            <dbReference type="Rhea" id="RHEA-COMP:12725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133386"/>
            <dbReference type="ChEBI" id="CHEBI:133387"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.256" evidence="13"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN55"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000010">
        <property type="entry name" value="Putative N-alpha-acetyltransferase 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="81"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9497934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="229" mass="26754" checksum="D25CBCA713A908C6" modified="2023-02-22" version="1">MNNDNSDDVNIVIKHNDNNDDEQSSSTMATMLTNEFDQIKISNTSMMKLYENPNNLHNDNDDDQLPESNSSSSSSQSSSIEYICYKNETQMPDIMRLIQKDLSEPYSIYTYRYFIHNWPQLCFLAMDQNVCIGAIVCKLDYKKRKILRGYIAMLAVDERYRKRKIGSNLVLKAINVMIELNADEVVLETEVTNRPALMLYENLGFIRDKRLFRYYLNGVDALRLKLWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPE9</accession>
    <name>A0A922HPE9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Charged multivesicular body protein 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CHMP2A</name>
        <name evidence="3" type="ORF">DERF_014578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPE9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="217" mass="24665" checksum="59B95F801A48A4C5" modified="2023-02-22" version="1">MEWLFGKRKTPEEMMRQNQRALNKAMRDLDRERGKMEMQEKKLISDIKKMAKDNQMDAVKIMAKDLVRTRRYAVSLKIQTLRSQNAMAQAMRGVTKAMQSMNRQMNLPQIQRIMQDFEKQSDMMDMKEEMMSDVIDDVIGDEEDEEESDAVVSQILDELGVQLNQKLSDLPTANSTLNAEKSKAKQGPVPAAEGAGGAPLDDADADLQARLENLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ61</accession>
    <name>A0A922HQ61_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_013434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unkempt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040594">
        <property type="entry name" value="UNK_Znf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057295">
        <property type="entry name" value="UNK_Znf_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057296">
        <property type="entry name" value="UNK_Znf_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045234">
        <property type="entry name" value="Unkempt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493:SF50">
        <property type="entry name" value="RING FINGER PROTEIN UNKEMPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493">
        <property type="entry name" value="UNKEMPT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23261">
        <property type="entry name" value="zf-CCCH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25427">
        <property type="entry name" value="zf-CCCH_UNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23035">
        <property type="entry name" value="zf-CCCH_UNK-like_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18384">
        <property type="entry name" value="zf_CCCH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="585"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="625"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="826"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="585"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="625"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="826"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="904"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="956"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1032"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1266"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="956"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1033"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9497441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1386" mass="153888" checksum="E9C2DCE647969B77" modified="2023-02-22" version="1">MSSLNLGISSTTTTIATNINTTTKEQQLLFRNNNNNNNMNILQAAAVAAASSAATAISNTNNSQNNGNGGQQPQSQQQQQQQQTQLNQMNNFDFSPMIFRSMSDASAIRRNQQQQQQQHQQQQQSMNQSSLYNNNYRQQQQQQLNSLYGTSWSTNNNTNDQPYPDLMTIISPGSSSSSLFTTTGSRMISLMNRNSFLQQQQQQQQESNNCDQLFNKTTTTMNGFINTSSTSTSPTMVTSSPSVSSSSSSSSSSSSITATTTSAAAAAITTTTTIINGQRLTNVNNNQTATTTTDDDDYDLNLVFDEIGALQHKGLNEPEDDNSTAPLQLLSPSSSSTVKTDQTQTIKQQQQQQQLTQILAQIEIDGKIYKYDTELYDPMDITLANEKYSMNARVAATTAPAAHHHHYYHHHHYGGGGGQSRQSHCMIQLDQNHQNNSLKTIIHHQSSSLSSSPRSSSSSSSSSNRSSPFNGSTTTNGSNKFVDSTTMSTTTTMATMMMINGNSNISNGGCNNYQRKNRLNHQQTSTLPTEKLSHYNYLRDFRCEQCPLFLQHKCTQHKPFTCFHWHFANQRRRRPLRKRDGTFNYSPDNYCTKYDDTTGICPDGDDCPYLHRTAGDTERRYHLRYYKTGMCVYETDERGYCVKNGAHCAFAHGSRDLRMAVFDIREQQQITGTNSLTNGGNIHCDGIGGGINGVIGSHDGLINGDHLINGGTGCCQSSSTSTQHMFDKDRCAIHEDPRWQNTAFVLAYYKTELCKRPPRVCRQGYACPQYHNNKDRRRSPKKFKYRSTPCPSVKQGDEWGDPNNCENQDDCIYCHTRTEQQFHPEIYKSTKCNDIQQSGHCPRGPFCAFAHSENTDEINMAKEFATNPNTELLPSSIINNASTATNQNNNNNNTSPMEIVRANSYSRGSSSSAASNHNTAAVNNNNNNSSSSSMMIASSLPEHVEFGVFDLNNAQQQHQMAQNELTASQNNSQPQQNQNNNQNILGPIARPRSFSTSNTMKTSTSSALMTNWLENKNSLLHHKAAAFINKNLQQQQQHQQQQQQQQQHQQQQPQQSLFSTASSCSSLFPGTNSIEPVLSNGGCGPFSTNSLYEQQHQQQQSAVATAFDSMLNNHDLSFDELDNFVPKTANVIDNCHSSTTAMDSAAAAAAVQSSFGSMLRRGSYSFNESEPINIPPRGIMANTNGELHHRSTSASGFNLSPPNHQMNAAAAAAAASPILGSTFLATRQHSLPANQSLFDQFAVAANLNNVNGTTAATTTNQTQQSVVAAIMEMQRLKEENNAAKNRFFESQETMQQVIQWCQLQLNEAQKREKMAEKQRDEALSRLDIREKELEMMRTNESNAFQKRKQDLSTMPRNQLLQLKQKLSQDLSCIEEALKTMSTGNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQJ8</accession>
    <name>A0A922HQJ8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQJ8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9498010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="145" mass="17141" checksum="0A4A11B151387884" modified="2023-02-22" version="1">MDYGVYMHEVPVYFIARYRQIRQQQQQQQRLIDQIPSLLIDCYMFCILSKQNKLIVNDIDGIFLKELRDQLDVVVDDVCNCRKTRESCANNNFFTRLLTVCNIECINVNRRFNPNNRRLFSSISMARSSSQLWPPVLVVVNIRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRG3</accession>
    <name>A0A922HRG3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP-binding protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GTPBP6</name>
        <name evidence="6" type="ORF">DERF_010699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRG3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000886">
        <property type="entry name" value="Putative GTP-binding protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="entry name" value="GTPase HflX, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229:SF0">
        <property type="entry name" value="GTP-BINDING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="GTP-BINDING PROTEIN HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="5">
        <location>
            <begin position="237"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9505936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="464" mass="53583" checksum="2FECD8074D942CF0" modified="2023-02-22" version="1">MIPFLSSISFGRLNSKILYNVLASSFHNNHHIQCRSIHQDDSMNDSNQDDDHDLLNDVFQYNLLVDLSPKNVVVIMPRMKKGDLYRMRLILKKFFGSTNRNHLRDYVRQESADAVVFAINVLRPRQHHFFRNFFDVEVYDRFSTVLKIFRERCSTKEAKLQLALAELEYVKKNLHHLQECDFSQFSFSKSFGGNFDTFYQIKKQIIQERESRLKRSLSTVTNAYEIKRKNRTTMEIPTVAVVGYTNSGKTSLIKALSHDTSLQPEDRLFATLDVTTHQITLPSKMKALLIDTIGFISEIPTTLVHCFRSTLREICTANLIVHVVDASHPNRYEQINTVHQTLKEIEVPEKLLQTMIKVSNKVDKLSIPIDNIDGIAISATERIGLDKLARQIQKGLIENTERLAFEMRVANGGEQYQWLYREASAIVEMKPDPHDANFLIMKVLITKSKFGKFVKLFHANLNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS39</accession>
    <name>A0A922HS39_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_010978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS39"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="105" mass="11450" checksum="C7CA1955935E27A7" modified="2023-02-22" version="1">MVLDCFYGPFNQNNRSSPKLSATSLLYFATGVISFVFYGNEWSSVNLGQQDNRTAPSKDTRWLTSSPHGQTTTSQSCGIKLIATIDGNRNLKQLASEPASTGQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS70</accession>
    <name>A0A922HS70_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS70"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="110" mass="12123" checksum="08FF66DB8A17B066" modified="2023-02-22" version="1">MIDTARTTLQLGYTCGRESAKNKGARITIWFSMLYERARFSGFRLLRCCSRASDYGDSLVLAEDCLVGSALSDLMTRRFDAEDGCGSFGDEPFTGGRSSLRRNAALVVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HT97</accession>
    <name>A0A922HT97_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HT97"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7676" checksum="E74A5E6CD274BD8C" modified="2023-02-22" version="1">MDYSHHCFPDPEANKLQIWFEIRSICLGLELLSNSHFIRREEKITADASCILVAAKHCNCHIIHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU15</accession>
    <name>A0A922HU15_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALG8</name>
        <name evidence="12" type="ORF">DERF_009467</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU15"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9510980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="613" mass="72355" checksum="5C354520F1CF5B50" modified="2023-02-22" version="1">MTATDLRSKSRSSITRGSDDHKRIKEKRSEYDSGTIWFMFYSTATIVTCIKFLLIPSYYSTDLEVHRNWMAITYNKPLSEWYSESTSKWTLDYPPFFAYFEYILAYLAKFFDKNMLQIRQDPYMSPETLFYMRLTVIISDLVYYYGVYQWIRLMYKRKPHIFTSLPAMCTRSNFFQSSTSFSHIVLFIFNIGHLIVDHVHFQYNGFLNGMLLISMANICNQKIYWGSFWFAVLLNFKHIYLYMAPAYFIYLFIEHCLIRDSRGSITMKIRLNILLRLIAIVIGVFVVSFLPFIINGQFYNLINRLFPFQRGLTHSYWAPNFWALYNGYDLLMARFYRTTDRQSPYTGGLVQQSEHLILPTITPAITLAIIVVIIITISATYIHQQQNNNRTKTTTSRNQNQNQNSVAYAPEIRFLHLILLSSLTFFEFGYHVHEKSILLVIPSLIPLIFVNIDYAQIFLLISIAGYYSLFPLLYKEAEAMLKVLLMAIHLLLSFGTLNSRYRIVKRWVIEKITTYVDSDDDYGTEHEVMREIKDEFRENPPFSFLKLPLLNVLESIYILGFIFIHSVYTFGPYIFPDAFERLQFLPLLLISIYCSVGILYCYNWLFTMFFFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU67</accession>
    <name>A0A922HU67_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ecdysoneless homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU67"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="61386" checksum="9A045ACD7714F56F" modified="2023-02-22" version="1">MNQKKSFDHRNIIDQQYLFGQCNYGENIEDEWFIVFLLKTLTEFDENLFVRIQDEDGEFLLIESAEHLPGWAQEPHRTIDRVFIHRGNIHLVSSKYVKKDSNALNKFSLDCIDFIRSNPNKTECNESIQQCIRNRIKIFSHNLDKLHHNARCLLPISLAILLDHHPELIAAAVRAFYYRTPDDVKIIGTHQFYSSDNQTATIITNVRFNRCLYAQLVSQDVTDVRKLLLSSLSNEDRIHQNGAKIIAGFEILLKNYQHMKSSLDSENLASAAKHVHEFLTITLTDELTSKFLYNREQKSLPSEDDDDSWLNIDEEQFDRLLSVKFNQQKQPSSSSSSATKEEIVKNIPETLMKFFQNQNAGLDGVEPPPPSPLQPKAANESKSTKSFDLIKEFNEKEFVEFMEKMAILESEDYSDKSENDDTDTDDDDDDDDDSNKLPEMEAYIAKMDSELAQTILANSFERAPKELDSDDDDDDNEENDLKYNAVSNILKSLNEEVETADSDVVGPATALFAYMNQSLPELKINPSDKKNLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUF1</accession>
    <name>A0A922HUF1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-dependent RNA helicase Ski2/MTR4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUF1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase Ski2/MTR4 C-terminal" evidence="2">
        <location>
            <begin position="440"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9510630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="628" mass="72833" checksum="19CA0BA28FD78FF7" modified="2023-02-22" version="1">MYLRSGKSKRTAPESKKSFQIFEIEQNIDEISSDESTGINSENESCESSMSSDLEESNMTESDGESTEIDESTNEDEDANDDWLDVEKIPEIFDFNGCEGVKQNWPSNIAPFEAFSLIFDNVLVEKIVKWTNHKAKILRSSRTSRQSTMRMWKDTDAQEMKKFLGVCIVMGNVKMPSLRHYWATNFIYNHPFFGRFISRNRFEAILRCLSFYDNTDDTSNRLHKIKNVVEHIVTNIQEIYSPGRNLSLDEALLLWRGRLFFRQYIPNKAAKYGIKLYELSTPNGFILNILIYEGKGTVYNQSSSHAHGVVQKLMDPYLNKGHVVYIDNFYTSVNLAESLLQQKTHIVGTLRKNRKFNPKEVINKKLAKGESVWKRKGNVVVGKWKDKREVCMISTYHEFKMVNWKNSRGIESMKPNIIIDYNQFMAGVDRADQMMSYYSTPRKTVRCADELLLTEMLFDGFFNDLNVYQIAALLSCMVFEEKTEILPKLSEELSKPLKTMQEFAKKIATVSKETKLEIDEKVYIEKFRPNLMDVIYSWTKGKSFSEISKMTDAFEGSIIRSRAPGSSDEESPNSLKLSNNRYLTVSEFKNKVDIRVYYRNDEDGEQKPGKKAPVYRRMNGKKLYPTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUS3</accession>
    <name>A0A922HUS3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_011551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUS3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9506839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="512" mass="58440" checksum="F745BAAAB63EC2DD" modified="2023-02-22" version="1">MSTKYCHRFQNINTVCARNHRLFNYRFIIYLSYIFCLSTTSTSISIMANDQFLIAQSSSSSPPLQSIMLARTLPLVQSYGDDNNSTTPICPLYIDSGGNGDDHNHNMTLNPCHCYGSIIMGIFIECTGANIRQINHTLNHLRSSHSQQSKSAVHSLSIYRLNTSSSTPSLPDHLFNSFTLINELHISSTNLTRIGTIQTYNGLEESLNSLSFVDSQISMIPKSTLSKLTRLKSLDLQSNHISNLDSYAFYGIPLRALNLQNNRIKNLQEFAFGGLENTLEELILNANLFEHFPLFALRRLRKLATLKLQNNQINQIPDDGFTRFTVLETLDLQSNHIRHLNSRSFMTMPKLKILYCSNNLLTVVSDSSIFQQLPLLETLDLSLNRLRVVNLDGLESIRTLDLSYNHLHDLRLQSLTGLRELFASNNNILQLVNETFMNTTNLEVLYLQHNAIHSINYNTFYHLQQLRILDLSFNQLRRLHQSLFKNTNLLQSLYLDNNLIDDMGIEPVMTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV97</accession>
    <name>A0A922HV97_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L14, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MRPL14</name>
        <name evidence="10" type="ORF">DERF_010959</name>
        <name evidence="9" type="ORF">HUG17_9471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7642780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV97"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000018">
        <property type="entry name" value="Ribosomal protein L14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L14, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21037:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7642780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9506218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="148" mass="16435" checksum="3353EB8B943A5D36" modified="2023-02-22" version="1">MFRRLSINLVPTRTAPPSVNLHTTGSMQWVQKQTRLRVVDNSKLGREAMTEGKQVKCIHVYKKNAKVHDGQLGDKVLVTIKGQMKRGYVVGLVAEQRPMIAKFDTNNVVLIENNGNPSGTRVVVPVPNYLRSKGAELAKIVAISSRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVA7</accession>
    <name>A0A922HVA7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVA7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="195" mass="22327" checksum="D80999FCE0161555" modified="2023-02-22" version="1">MEKSTRIFKPGGWDARSDMVLDKIIKCYMTRSDTTDIDISEAGHLIPIRVDSVIYCPPTAIADIHIASSHQIPGKCQLAKIEEIHRMMVGYIARSCFDDYREGKERELKEQIAGQPLFDRGFHISQDHQKNHGMAAAHVCDELDIDDQQMVQIEKSAVRILQQPRVQLRKDSDVCGHKKKVTSEKYCWPHVIKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW63</accession>
    <name>A0A922HW63_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ANAPC4</name>
        <name evidence="9" type="ORF">DERF_011824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW63"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="8">
        <location>
            <begin position="326"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="938"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="940"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9507125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1063" mass="125149" checksum="3E924845C24DEE97" modified="2023-02-22" version="1">MTNFRKVGERLLPLEVSHIRINPCMDIVALSLSSSDIAINRLFSWQRVWSIAKPKIHQNDNVEIIKIIDMVWSIDGKILAVAYNRPIDGENRNKNSKNIDENCTTKPEYHSSIAMYLIETNQRVCVHNLSFNITCLCWQVKSHCPDVESSTMKAINIDDLNLPLDSINIPYVDLCICDDELLNYPFNTTTQQLGKNSKLPAGDSNKNSSSKKFNSILPPLTRINRQDEFVSYDRMNLLQNKTINILTIGTEQNIILFYLFGYYQILNIDLKQFIHNDRQLRIDRIWISPDLNSIQVYFKCNNNNDKQQANSNLMLFETRLFGNLWKEIFLVNRVRLNIDIRVEFLHDTIKEISSIWSDVIVDIKSRLSGYQLIPEQTFDVSNSQQMDQNRIQLKLKDFIDMLIFGNISLNLERFLHDLNRKETSKLYHSFEHCIDDINRLIITRLLNTLTQILSYLDNLRGMILNDLLFGDLGLSIENVNQFRCEITWMMDKCNRLMTTMNDLKCKMLAVTRLIYKGIFMAHYSHDHNEHEYSKYCDDHLDIGRMTLQDFHLIMDFFNDGSFTNGFEFHRIERMLDPNSQSSKTSVEISKNDDDENIRNPYKTYLEERYLKNFLNILNDHKGKNFNEMSVEDLFRLFSGTFPSSNDSMMKFDNLPDKDSDETRKWFEMLMNDSNNIDSISENITSDWSLSEHHERLSRIKQRLFGDSFEHMNELQSKLIEKSVDKMTFEFHHDFDCTKELYEIEPISLDCHSVLCYHPNLNEQSTRYLYVGKFNQNHHDDNQTTMMTIFRFQQPLHNQIDLIQFNLIGNCHSSCHCVDKIGFYIEDCRFYNSEWMTLIITEYHRFNEQQPTTSSSSSTMENNESNRKQYLLQCRYSKMFDSMNDFIVERITKQNRKTFNNHAWKIDIGTIMDRIWIDEQPQQHQQQQEQQHMQIDGNDYVAHDKGNDNKLDDDDGDGETPLTIDSFFKLRLLNDMMNNNKHYQQKSLSVSGNRNLACCCDSSHCRITTFEMDICEDDDDDDNIQDQDQQQQQQQQLSDIIEDCNIEVAQLIEINPNGNDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWD6</accession>
    <name>A0A922HWD6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RECQL5</name>
        <name evidence="17" type="ORF">DERF_006679</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWD6"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000444">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF152">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="124"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="359"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="649"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9515904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="764" mass="87111" checksum="B2BC4BEF6B4B2398" modified="2023-02-22" version="1">MSFSKTKITDFFQKTNGGLNGLAKRPNNSSDFSFHKKSSQSMNKNKAKRKKLEFTSSTSYQLSIVDFDSNDNDGATNEIDSSISESYPIKMINPSKSYSNAKEVLEIVFGHRSFRNTSQESAIKKAIEGKSDIFVSMPTGAGKSLCFQLPAVFDNTKITMVISPLLALISNQVSNLRKLGIACESFNSQTSDAEKQRIKKDLISANVSIRLLYITPEMAASTFFNEVMNHLVRTNQLARFVVDEAHCVSQWGHDFRPSYLKLGVLKSNHPSVPWMALTATASSKVMNDIITILKFRQPVDKYIMSNFRSNLHYDVHYKDSTNKTLEDLKNFVIKELGSNDQNLFNKMSTTESIFDKAAKLSKAANNNENKDENVGIIYCRTREQCEEIANFISRAGIKAHAYHAGLTANKRRECQEKWMKGVIKCIAATISFGMGVDKAQVRFVIHWNLPQSLTGYYQESGRAGRDGLPSICRIYYSTDDRDAIAYLIRQDIEKRKTFKSSVKHGGKDSYDYEITMKNFEKMIGYCENFQKCRHSFILSEFVGDENIVNRGCGSCCDICCDPRTVQKRFEKFQAIRMKNLFNSQRTNNEDDDSFFLPKLDETKDQDEFRKKKENRAIDTVKEEFKKRKTTIPPPKSTFKSASTIVLETAIKKSSGKNEKSDRNQHPSEKNQNTTKKDSIDDATRQMFRDKMIAEIKIHLHHVNNSNNFTDSTIEQMVLQEESKVFSSKSPNRMLYRASIANLLKQIRDSTKSQQLNATIKQYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX00</accession>
    <name>A0A922HX00_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX00"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="192" mass="22322" checksum="FE9FA6653DB9876B" modified="2023-02-22" version="1">MMIDTKSIYHCGCGIELLKHAAISIEKKNFLSHSSSSLLSKEIMMANNDYRIMNGLFWLKNAAIFMINYGQNESDSNDHSIRSPSQSIASEIEIDDQSFDDSTSEYYGVYAEKLESHRDDKLTLSNNSVSHLVDCSHDTVTNLYNDHAYAKRPCCYKCNCQRERKILSKQNRKLLRFQTLFETKWKQNQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX92</accession>
    <name>A0A922HX92_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase makorin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MKRN1_3</name>
        <name evidence="5" type="ORF">DERF_009409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX92"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9510919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="237" mass="28454" checksum="67B69B541FB0B7F9" modified="2023-02-22" version="1">MFSNQSNYHQIYDENRKKYLFENGDERIVQDSPLPVNDHSEDELIRDILRNFRCPILDDGNCRHNNRPEDCNNGEESNKRLPTFVCVYNLMKKCNNVVFGDEPRCIEGFHIKASYLSNLDKFEHDNQRSITGFFYRYCVQECAVCKEKICDKRFHKQRRWALLENCSHFTCLPCMGKYRKISHNCSMCRVHSDRYIWSNWHQIHDENRKKYLFKKGDRQIIEDRPMCVRGHEPIDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXU4</accession>
    <name>A0A922HXU4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thyroid adenoma-associated protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_009706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="4">
        <location>
            <begin position="421"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="3">
        <location>
            <begin position="817"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="5">
        <location>
            <begin position="1133"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9511234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1622" mass="189842" checksum="3947C38DF622D6C0" modified="2023-02-22" version="1">MLNLPGSRKYDDRKKLKSLITKTKRLTLIYNENFKQILSSFQSFFNNKSSMKNVENTDLNQCIRQLLSSLRSIPPPLLLEIDDEIEKYVIKSLNRLQKIYCDDSVFPETAILSAFCTPFILMSFLSLKYRSNIDHDKICRISFVLYTQMFAQSIEDDEFVDKIQQIIGQTNPIVIVEHVRQQIDRIESTTTSFCQATFYYGILNCVPFFNVLIEDSIEIFAEIFMKLIRLCRIETKQTFQIYRLLNQYLKLLNDHQHVIENQILNNKNLKNFLSNIVQKTLSIVDSEWESPINGAITLMKENYQFLIRFIIQTRLEDEKFIEKILIEQIQSASQLPFTSKAKYKKLAVLTEFLSVQTKNDQFKLLPGSPFEMDSNFSDKMIKHLSITAITTSIADYYKCTISWILSSTRIDNNQRNIQEKWSQLWLRPITQIFRNDQIQFMIVHNIMMASILPATLQHIPQSMSLMMEKLSDCPYGQVCLIRIYLEKYSQITESSSAYKLPSINWLITILTNQDDMIRVEGLALLADEKLIKKNRPIVCDLILRFLRNNLNVDNSSFRQRMIRVLERFFFKIITCLCDRYGGGVGGHSQSINQEHKPLVSFISNTLRLLAISLSPGSSFQRKSTALNLIAAIITLIKSGDYHLTIRRLLTNDDHDQQELIEPIPIRFMLLYGIIDKDDKIRRSTNEILIQYSKTSLVIGQDDRYQFFSTKSVENLSIHYGRSFRHQECHIGGLLCRYLIQINPVENIHHIFTLVRNANKLFYSDSFRKQLLQSSQTNPLHGWLLTLNQCLDFDNLAHHLLDMNPSCQNGPINIRYKIVEPTIELCFDVLEYFLALLTPKNGDEDVDFEYPADDGDEMSESIRQIVQKETEFDNEKDFTMTNEFQLILSMCWLNMKESCFLIANLSKLSADLLYCMINRTDYKDIRDFLLLSAEKLCQSIIRMVNLMQRCRHRGVIEACSVSLTKFTRSLLRIYYYLHQMVASNSSVLQAYRSAMEIFVQEIFAVIARNDKSRSKISITRRSAGLALIIQSVLIGEAESFQKDKIKLSNNNSCPRTLYEQFIDLLIQIAQSPITNDDDDDVTMQEKIDLPQANAMHVLRSILGTSVLSQMNYKTAEILFPICLNGFTSTHWQIRNASLQLFGSCITRLLGQKKRTKSKPMDNDDDDNDVVVVEEESTITLNEFYSRYPNLLKLICQHFEQSSSYENHRPEIVPVLALIASFTSFAQFHSFHDDDDQHARLIEMKNCLKKSFIQYVEKNRCWKIRMLAARSLANLSTFEEMNEFLHNSFESTHDHQIESLSWTFIFQDEIEFYRQKLYNRFKQHSQSVPAFHILRPLFLSIFNEKQDKQNNNLATKIDESNNDDDDDQLEIVSQDLHWILERTSFKNPDNIRFIAAKQMNQWLRQNNNADHDIKTLILIAEIVLTLLEDEDRHVRFEALKIGEIIFHDDQRILSTNITINMFIDWLIKSNHNGYRALFELILKRFAQSLSYVEQQSDGQMQNDVLFEKEEKNVFAEPYLMNIRLLNAFLHHQQSSNEIIHMILIHDQYESYRNDIMFKGIWRLPKYFLFLVDHLLFMRLALSLEPENGDYQKQESSIHKHNPFYLQELLTEFHPNKMDLIHFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HY45</accession>
    <name>A0A922HY45_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="11">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CDKAL1</name>
        <name evidence="15" type="ORF">DERF_007538</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="11"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HY45"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12160:FF:000003">
        <property type="entry name" value="CDK5 regulatory subunit-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000002">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="13">
        <location>
            <begin position="80"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="14">
        <location>
            <begin position="216"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="12">
        <location>
            <begin position="447"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9516819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="535" mass="61915" checksum="2BE2347DB819C0AD" modified="2023-02-22" version="1" fragment="single">FLSNFVFKIYFSAMTLEDIEDIYQNIDTTTNKNDNHSHEFKVKLNHRIYRKENEESNVVDDYNDDNSSIEPYQNFLPAKYSIYVHTWGCTHNSSDSEYMMGILAQNGYQIVQDKEKAQLWILNSCTVKTPAETQFRNEMKKALSKGKKLVLAGCVAQSDYRLPYLKSMSIIGVQQIDKVVEVVEETLKGNVVRYLTVRKKDGRKTGGASLHMPKIRRNPLIEIISINTGCLNECTYCKTKHARGKLGSYSIEDIVERAQTAFNENVKELWITSEDTGAYGKDIGKSLPELLDQLIKVVPNDCMIRVGMTNPPYILEHIESMARILSHPRVYSFLHIPVQSGSDQVLSDMKREYCIEDFCTIVDFLKQRVKGITIATDIICGFPTETENNFNETVSLVNKYRFPVLFINQFFPRPGTPAAKMKRVPTLEVKRRSRIISQLFNSYYPYNDRIGHKYRVLVTELSTDKKFFVGHNKFYEQILIAKHQCQLGEWIDVEIESVGKYHMMAKTLWRRWLMNRIRTTLLMGNANNDNDDQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYT6</accession>
    <name>A0A922HYT6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein llp-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_009274</name>
        <name evidence="3" type="ORF">HUG17_7221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the learning-associated protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYT6"/>
    <dbReference type="OrthoDB" id="6257894at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001099">
        <property type="term" value="F:basal RNA polymerase II transcription machinery binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097484">
        <property type="term" value="P:dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018784">
        <property type="entry name" value="LLPH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34253">
        <property type="entry name" value="PROTEIN LLP HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34253:SF1">
        <property type="entry name" value="PROTEIN LLP HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10169">
        <property type="entry name" value="LLPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7637015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9510766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="117" mass="14100" checksum="E29FBD02210F6E26" modified="2023-02-22" version="1">MAKSIRSKQKRKMRAIKRVRYGQKELKRLVEMVKKSEQNEKQAQEEMQAIAVKKFQIDVDENPNQNSDYISMETDQNERDKKTLLNKFGQYPDWMNGRRLKRQKTLVKKLKKKRSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZH7</accession>
    <name>A0A922HZH7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">METAP1D</name>
        <name evidence="8" type="ORF">DERF_007695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZH7"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="83"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9516993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="319" mass="36427" checksum="D01A7718FEE100CC" modified="2023-02-22" version="1">MLLSTRGTLKIIRDVLGKFNLYQASQKCSTTNVLSYEIIEPKYPKSHVTRYFPPDILLPDYAKHGQPSKHRNSVYVKDQKDIEKIWNSCKIAKTILMTTGDRLKIGMTCEDIDDIVYDLCLQHKCYPSPLNYSRFPKCVTTSVNNIAVHGIPDQRPLQQGDIISIDVSIYHDGFHGDCCHTFAIGECDQQAKHLMNVAELCLYEAIKICRDGQLISTIGKTIENIARKYEMDVVREFCGHGVGQDLHENPQILHYDHESNEMMVENMVFTIEPIILETPGNVVMFDDGWTVASENDCRSAQFEHTIWIRKQDAVILTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZM9</accession>
    <name>A0A922HZM9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STAR protein homodimerisation region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_010224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZM9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032377">
        <property type="entry name" value="STAR_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16544">
        <property type="entry name" value="STAR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAR protein homodimerisation region" evidence="2">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="255" mass="27992" checksum="9346DE79957ECB77" modified="2023-02-22" version="1">MPVKNATKQIFDMMIESSSSTTALCNGSGHINLDENMTNNRNDDFNHTSSSSMMATESSSSSSSTTTITTAAAAATTTTTMAIMYGEATIVESSSSSPLQLANDNDNNNNNIDGMIGLNDKNDDHNHHQQQQQQQPQLQQSQQQQQQQQQHHQSDDCHNPMSNGNQIPNSPATSCILSSSSSSSSSLLNHNNHSNNHNNNDNQTVHSLAEYLQQLLKDRQRLAAFPGTFLHIDRLIDAVMIDQFRLIKSSVTFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZW6</accession>
    <name>A0A922HZW6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_008411</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZW6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="59"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9517779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="183" mass="22060" checksum="AD702B9BAB669D4C" modified="2023-02-22" version="1">MFFRNHHHTNLIVNHFFRTSQLLQNSIAVSNYFKQQQFQIHSSQICFKFIPDKSRLPVLNENDIEEQFVQGSGPGGQNVNRLQNCVILKHLPTGIIVKCHQERLLQRNRKLARQLLLQRLDVHYNGTDSIVEQKKRYILSRLEQREQRFSDLRMKKLQYQKIFQQQRQKQQQQQQQESDYNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I082</accession>
    <name>A0A922I082_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I082"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9512082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="344" mass="39747" checksum="6078B0B610990CAB" modified="2023-02-22" version="1">MNNQSVVRNNNNEHHESSSNELIDLMIEFHSNRSKADDEFHSKRSKLDDEFHSKRSKLDDEFHSKRSKIDDEFLNELLKIQMKNNYSINEMKNDQQSSNAAMSSPNKTIPTTTYEKNESRQSKLTTSIDRNSTANNNPIENVQSQTNRRQQQQKQQQTNSIVRQTTTQKQSNQTAIPNNNGLKRKSGHHYVVSNDNNDFRLKKTPKISAQQTIVIANNLNMNDKNDSIVVDDDDDDDDDYENSRSSAHIPLYRFPCSHNGCQYVTNNNKYMNNHVKHHDGIMFCWSVASQELGNLFSCCSFYLFLKFSDDFGVWQQSVCPSSGARRSCSDHPFLVRFLPAQIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0T3</accession>
    <name>A0A922I0T3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_007307</name>
        <name evidence="2" type="ORF">HUG17_1730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0T3"/>
    <dbReference type="OrthoDB" id="6513953at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7646192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9516572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="167" mass="19302" checksum="0EF71DDEBEB926EC" modified="2023-02-22" version="1">MSKMTYFAPCVKRSINRRDDEDNHINGKIENNDNNEFMPVTKRMNYLSIENTNSNDTLISGSSSSSNCSTTSSLPNEDDSNDSGYQYQGPMKNEKTLMMMNNNGDHNTTTMPIINNNNHENQLMNLEQLYRTYNPSLKLQQNPIYYDANRILFEAHQMRLLRNIKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I124</accession>
    <name>A0A922I124_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1183"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1367" mass="132567" checksum="A1ED3ACE5D34C4BA" modified="2023-02-22" version="1" fragment="single">TNKLEPRTVYGSILGSNDDVEVKAVGTTDGSRPVTDIPAASWLGSLVVGSATITPLGELVSPLGSREDGSRSNLEVSIPGVTAAPSPLGSRPDGSRPKPDVTNSGAETPETSPLGSRSDGSRPNPDAVSIPGAETPGPNPLGSLADVGSRPNPDAVSIPGADTPAASPLGSRADGSRPNPDAVSIPGADTPAAIPLGSLADGSRPNPDVVSIPGADTPAASPLGSLADGSRPNPDAVSIPGADTPAAIPLGSLADGSRPNPDVVSIPGAEIPAAIPLGSRADGSRPNADVVSIPGAEIPAAIPLGSLADGSRPNPDAVSIPGADTPAASPLGSLADGSRPNPDVVSTPGADTPAAIPLGSRADGSRPNADVVSIPGAEIPAAIPLGSRVDGSRPNPDAVSIPGADTPAASPLGSLADGSRPNPDVVSIPGADTPAASPLVGSRPNPDAVSIPGAETPAASPLVGSRPIPDAVSIPGAETPAASPLGSLADGSRPNPDAVSIPGADTPAASPLGSRADGSRPNPDVVSIPGADTPAAIPLGSRADGSRPNPDAVSIPGADTPAASPLGSRVDGSRPNPDTVSIPGVDTPAASPLGSRADGSRPIVDCSPNSAVSRFFLISISISKSRPIIPRLPSCSEVSRPNADGSMPGAEIPPVKSVCCCIIAASGSLADGSLPNPDVVSIPGADTPAASPLGSRADGSLPNPDAVSIPGAETPAANPLGSRADGSRQNPDAVSIPGADTPAASPLVGSRPIPDAVSIPGADTPAASPLGSLADGSRPIPDAVSIPGADTPAASPLGSLADGSRPNPDAVSIPGADTPAAIPLGSLADGSRPNPDAVSIPGADTPAASPLGSRADGSRPNPDAVSIPGAETPAASPLGSRADVGSRPIPDAVSIPGAETPAASPLGSRADGSRPNPDAASIPGADTPAASPLGSRADGSRPNPDAVSIPGAETPAASPLGSLADGSRPIVDCSPNSAVSRFFLISISISKSRPIIPLLPSCSEVSRPNVDGSMPGAEIPPVKSVCCCIIAASGSLADGSRPNPDAVSIPGADTPAASPLGSRADGSRPNPDVVSIPGADTPAANPLGSRADGSRPNPDVVSIPGAEKPAASPLGSRADGSLPNPDAVSIPGADTPAASPLGSRADGSRPIVVVPVSCSRPSVEGVPISDVEIPPANRLWSFSTDASIPGADTPAASPLGSLADGSRPNPDVSIPGAVTSKSIPLVSRADGPRPNPDVVSIPGAETPAASPLGSLAEGSRPNPDAVSIPGAETPAASPLGSRADGSRRNPDVASIPGADTPASSPLGSRADGSRPNPDVVSIPGADTPAAIPLGSRADGSRPNAEPGSRAVTVGTFNKIQSQLESSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1B8</accession>
    <name>A0A922I1B8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1B8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="7718" checksum="4D55DDF27AE93395" modified="2023-02-22" version="1">MCVALTLTLFGSTITATITIFTAITATIFTAIAITFVRAAIAATIATFALHSHLLQRPMFAFFFEKFCLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1D9</accession>
    <name>A0A922I1D9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1D9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="131" mass="14918" checksum="4A72630FA9719DB6" modified="2023-02-22" version="1">MVKGFEIVGMVIAISSGGYRLFLSLSLSQCQDVQSSSRHPTGKLIYNNNRSNTTMNRTILLFVIVAFVMMATDHAFGSPGYTAFRMSKNGLRPRSADWNTYTDDRSDYDNFLNYRQKRNFLPLPPPLWVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2U8</accession>
    <name>A0A922I2U8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_007721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2U8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036767569" evidence="2">
        <location>
            <begin position="27"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="614" mass="68294" checksum="048963E647803B98" modified="2023-02-22" version="1">MFVISILMMMMMVSVPSTFFIGTIDASIPPLALRTTHNNNTLILHSDNNNDNNNSSSSIATSTVYFHQYLPNNINNDSEESVIIPTATTTTTTAKELNLNSSESRNFYNSYDPWTLDDPGNRHGYPPIPMDVVRNNPRDDDGQSDYEGDYDDDNDDIDSDDEQRQPPHDNQGDGTVTNTYNNDQNANAQKIIDEIDGDVDRQEHDGNDDGDFDIPWNNDDTTEFDQDNSASFNVPMVEALKGCKTVYKEISASLPGQSNTDGGGMGDDDFRRRRKKRSIEDGKIKNGAKRGSYIMTRECHFIDGDKNKQKNNPTSKGIHHKGTRTDESRFVPINADLPRYRNNGMMMKSPAHQYHNLPFPHHHLYYNHHAPTSSSSSASTSAFNGDENDGNIMTSNRRRRTPNYMDSNRVDPFFSSERRPTMNSYPVSNKYNYRHTSAADGSNVPTSIGKNGGGNGGITKRYSTRFNYFHQKPTTKKSNLDTMNHDYNTVPDPNAAQMAEFTGQNVNDFRTDAPDDPDDTDPEDLLLHNEASHDFAASSSPSKLRTRKGRHLLLADDGFGDGYDDGGDDHSGGGTNDDDYSDHDDHGQGDNSDGGSADYDGDGGQGDDYSGDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I339</accession>
    <name>A0A922I339_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="9">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_008381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="9"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I339"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="11">
        <location>
            <begin position="88"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9517742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="198" mass="23180" checksum="02008916A9B949F7" modified="2023-02-22" version="1">MSSFVTNIFQSMFSSSSITTVTPITMLQQSHDGDYEYGIGSGLRHQRPCRACNDFKTWIQTNQNQNQQVKHQQKNDDDNNSNATRSDCPLDKNELGHNTWSVLHTISMYYPEKPTNDEQELMKNFIKGLARFYPCETCAKDFQQEIHNDPPQTENRHSLSLWWCRQHNRVNKKLGKPEFDCRLLEQRWLDGWNDGSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3Q3</accession>
    <name>A0A922I3Q3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3Q3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037600949" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12861" checksum="62E376504C5CB09E" modified="2023-02-22" version="1">MYKYLLIIMLQLTVDNCLSRVACLKIDAILAAIEMNRQQFIDLSIEVDVNNFHHEQCIYQCTAYTTSGSHNGQHCQRIQFPLTIELDQYNGLDNATISLGHLRLIGCIQNQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I519</accession>
    <name>A0A922I519_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I519"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8705" checksum="3DF07D43B6AABAAF" modified="2023-02-22" version="1">MPIVFDEDSSIMVWIGQMFTKNLNIRIQKSFNYCCNVLYDRNLNQILAWHTVTMRSSCCIVHDMKCNVSLRAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5B6</accession>
    <name>A0A922I5B6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5B6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="265" mass="31165" checksum="2F93D3D44C51219E" modified="2023-02-22" version="1">MADNNSNDGSLFFGNNGLLSALLDRLNRRLTNNYESTNNGNKNKNVNNNNNDDDDGEFIRTNYVDSFFRRYGILSVFMNDNKNSKFQTIPTATTRRPRNFIYRSRSNRPRTSFQDPFLAEEKLCQSHNHKSHKFSPIIFCQCHFKLYVNSVCDCLEFTKFLIVWIVHENPFVDIDHHHHQHCGHLKNDRFLNYVCSEIVNKIPIINPRKWKVQKYQIKDMRQEKMKNDPVNMINQSMIVFRNMIDKFLSDIRHGGGATTFTSGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5N8</accession>
    <name>A0A922I5N8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_004768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5N8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF2">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="118"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="216"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="303"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9521091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="724" mass="81306" checksum="66F8CA94EF5F733B" modified="2023-02-22" version="1">MSSSSISVVKSQVSSSDLNYDDCSTTNGTITFELITGFVFTSSTDTVTMMIPGVLHLAECLDHCRQNQTCNSLNFETGLCVLLSSSALQLPDALTPSQFPVFTIYAQKICLKNLSTSCANNGWAFERVSGFELREHEKRLLQAPTSQDCMQACVWEQKFQCRSINYESKTGECWLSDMNRHTVNINTEIRSQKYGPSSGNIDYYEFNCVQEPKRLCDFKPIHGRILKTVDSVYQNITTIEECQRQCLQGPYKCHSYDYGDPSNPVCRTSHLDKISLAHIDNPYIEIAGASTYELQACYDVNIHCESREMVAKVRSSKIFDGKIYAKRKPYHCMTDVNESLEFEIHMGYNDLECDVQQTSRGQYTNDIVIQHHDMIVTTQDLGLNINCKYDLSNQSISNNVNLDITGNLQPIGTHSAVVDSPNVTMTIVDMDGANVRAAKVGDQLVLRFEIVDQSTPYELFVRELIALDGSDMSEFVLIDSDGCPTDVAIMKPVLKSRESAKTLETSFEAFKFPSSDIVQFKALITPCITNCEPINCNLNLPNGRTSQSISYGRRRRRRSPSNADDNNKSDINDPRQNVIVVESLSVTDKFAVKDGKKRNKIEQNNHSEVYADFEDSISINGLPRMEITSPCVNVISLMIFAVAFLVCQTILIISWSYIWSKKRKNSLLENELIYGKASSASTQWSLVPSTKSINRMPITKRTCGPLQSSSIVYSVPSRQHGYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5Q0</accession>
    <name>A0A922I5Q0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5Q0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9525892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="126" mass="13527" checksum="EEC6AC9B76AB034E" modified="2023-02-22" version="1">MIFVLFAIIGAVSGHFYGYYPGYYGRGGFYRYGYGGYRRGWGINRWGRVYVATAAAAAAAADAFIRIILFFIVATILAITDAKLRWRKGGYGGIHNGRIYGGGFGHRNGGYGSIGPGGIYGGGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I688</accession>
    <name>A0A922I688_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_006438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I688"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041686">
        <property type="entry name" value="Znf-CCCH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15725:SF14">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 11A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15725">
        <property type="entry name" value="ZN-FINGER, C-X8-C-X5-C-X3-H TYPE-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15663">
        <property type="entry name" value="zf-CCCH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="130"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9522886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="479" mass="54702" checksum="45AAFDCF02FE490C" modified="2023-02-22" version="1">MNTMDKNNDCYFYFYSTCTKEKNCPFRHCDLALGSEVVCELWRVGRCNDRNCPFRHMEPNIKRSTTQCWFETQPNGCRKPHCVFMHTKPRPSITDLQSNIAEWILPTGHNINQQQLTTNTKQNSQQIKPNIVNNNDGNHQDLSNNSNVQNNNSKESHITITKPQLQSTEQLSISIDKDEESDDNNEIDTVPDDDGHKQPEQPAIKTLEQIKMEKILHSSPNEHLMDATNNHSLTKSSVINKIDMKFDNLTTKHSPSSSIAAPLRAEIKRSMPIKQQENIQPPSQSKPLHEERPVNVVVKTLEQIRKEREESEQIAATAVSKENQIPNSYKRTLMDNNNDTDDQSSSSLIPSKPIKIRRNRLTTSTLIMMTNNQNSNSSIEDNNELESQQNYSRQQQQQQINSSTTTEKSSLNQDDIITHGQQSTKLSNNDYNDDDLDLEFLHGGDHVEPAVAINSFSAEFTNIDDDDELMREINQVINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6V0</accession>
    <name>A0A922I6V0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Vesicular inhibitory amino acid transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 32 member 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Vesicular GABA transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DERF_000576</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Derf</strain>
            <tissue evidence="21">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Derf</strain>
            <tissue evidence="21">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4-aminobutanoate(out) + n H(+)(in) = 4-aminobutanoate(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70979"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>beta-alanine(out) + n H(+)(in) = beta-alanine(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70987"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70983"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6V0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060077">
        <property type="term" value="C:inhibitory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140800">
        <property type="term" value="F:gamma-aminobutyric acid:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051939">
        <property type="term" value="P:gamma-aminobutyric acid import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000062">
        <property type="entry name" value="Vesicular inhibitory amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF689">
        <property type="entry name" value="VESICULAR INHIBITORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="20">
        <location>
            <begin position="105"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAH9526492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="530" mass="59696" checksum="29C38CB8034AC2F0" modified="2023-02-22" version="1">MNDKVSNLFNTWSSLKERVRSKIPESCTEAVEKIRNRRGDEHEMGTFRTFEQTNQTGGLPYGSQMTMEAVTGYGEYQDGVPNGYYDGQQQPPPHFVDPHTGTSGKISAWQAGWNITNAIQGMFIVCLPYAVLHGGYWGVFVLLFVAYICFYTGRILVHCLYEPNEQGQMIRVRDSYVKIAEACLGEKYGGILVNTAQIIELLMTCILYVVLSGDLMIGSFPEGVIDQRSWMMISTMLLLPCAFLTNLHSVSTLSFWCTVTHIILNVIILGYCFIQIGDWQWSKVSLRLDMGTFPITLGIVVFSYTSQIFLPTLEGNMQNPDEFEEMLKWSHIAAGLSKALFALIGFLTFGEETQDVITNNLPTRGFRGLVNLTLVAKALLSYPLPYFAAASLIESALFRGRPTEQRPDGEGDQPFPTCWGRDNELRVWAVTLRVLLVLFTMFMAVSIPHFVLLMGLIGNFTGTMLSFVWPCYFHMKLKWYTLDIRHIAWEVFIICCGVLCGIIGIITSFTALVETYHIPLPYPDQNAMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I729</accession>
    <name>A0A922I729_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_004892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I729"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="75"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="525"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9521219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="627" mass="70480" checksum="8AA82868421A176D" modified="2023-02-22" version="1">MLKFITSAANHGHCYLFGVLTNRFNTRINTFGLRSCRFIASMVQDLNDSNLSYVHGCPPTPIATYSPLTIGELLKRSVAIDPDRIGFIVAHQNISKTYSQFDADVDRLAKALRSLGCRRGSVVGLWAVNCYEWLLIQFATAKLGAIMVAINPAYKERELLNVFRLIGIETMIMNQQFRYSDYGKVMENIAPGIFASAQHGSARVHSEQLPQLKNLIVIDQTDGEIVPLNVCRFSQLMQSSFPEKDTHKSDENNDTQFDDVINVQFTSGTTGLPKGSMLTHFNIIQNGQFIAPILFEDLNEPPTVCIPNPLYHAFGCVVGTVASVFMHGTLVLPGPIFNADTTIQSIEKYGCDYLYGTPTMWSDLLQRPLHQYNLTTLKRGVMSGAPCPSVLLHKIRQTIPSLQNILIPYGSTEIGPVATCTRINDSEAHKFESVGLPIPYVEVKVTDIKSNRTVRRGERGEVLVRSHGTFPGYMNQPDKTDEVIDDNFWYHTGDVGWMDQQGYLHISGRIKEMIIRGGENIYPKEVEELIMQMTGESIEDVHVVGIADTRLGEEMVAFIKLRSGKTNEWTEKSLKDHLRNKMSHFKVPKHIHFIDDFPRTPTGKIRKIDLKQMATQMFATESDQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I792</accession>
    <name>A0A922I792_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein polybromo-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PBRM1</name>
        <name evidence="14" type="ORF">DERF_000766</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05517">
        <property type="entry name" value="Bromo_polybromo_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21984">
        <property type="entry name" value="HMG-box_PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000006">
        <property type="entry name" value="protein polybromo-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="200"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="372"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="560"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="694"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="13">
        <location>
            <begin position="971"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="13">
        <location>
            <begin position="1190"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="12">
        <location>
            <begin position="1490"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="9">
        <location>
            <begin position="1490"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="462"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="467"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9526702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1946" mass="220034" checksum="E25C973D5B89A79E" modified="2023-02-22" version="1">MPKRKKSGYDDGIDGGKRRKYDLSEQLQELIESLRNYKTSQGKQLCETFMRAPKRRTLAEYYEKVSTPIDLLRIQQKIRMDEYDDLEQFESDIKLLINNTKAFFKPDTTEYADAIKLWDVYVDLKNQIFGSSSAASSDESSSVAAESKNDSADEKSEAETSSIIGVDQLSVMCVSGGGGADDEDLFEELFGAIMSAVSDDGRQLSTMFELLPSRTAYPDYYDIVTEPIDLKMIASRIQNHEYNSLNDLEKDLILMIRNAKMYNAPGSQIYKDANALKRTVQQKRSEIETRRSTPAAKSSERIRAKRQNPFGQQNKWSTIAAALKYDEDGQGTSTAGDDDFDENDLNFSDSEHDQDDGTRDSNPHWMLYNAVYDTPHSEPFIRLPSRRIYPDYYKEIKHPISLGQIRNRIKTNQYDRISDLLDDLKLVFDNALNYNRPDSKIYKDAAKLKKILQMKAREIMSVYKDEGGEDDDDYDDDDEDEDVADTANDDNDDGDSNSMIPSPTKKSKAGQRPSRSSKRSMVNAMSQELKNVRRSQKAINSQQKSRMITLYRTVLHSDDNGRLLIDPFMEKPSRKMYPDYYDVIERPIDMKTIESKIRNNLYESEASLVNDFRLMFSNCRRYNEDGSLIYQDADRLEQIMDSKLLELGPPPNATISQLDSNGQRMKKERVRPSSAIQLKMKQLFDAVHGYTDARGRQLSAIFMKLPSRTDFPDYYEVIAKPICLEKINQRIKNCVYETVEDLLSDIILMLDNACKYNEPDSQIFKDALTLQQVALQTKIGLNVDTVNGIPDVKIIVQDLLTNLFISVYTHQDEEGRCFSDSINELTETNPIEFKTLNFDIIKRNLNLGRYRRLDRFQHDMFEVFERSRKVSRTDSQAFEDSIELQSHFIAMRNELCRNGELLSSRALNYNLNALQAHIETLRQEKVPKELSEEESNRQTIDTDKDIDPVVLGIGGPMQTINEDEAVFHQDLMLKVGDFVYVEPHDKNLDPHIVYIESFKKDNTGQALIHGCWFYRPPETFHLASRRFLEKEVFKSDNYTNTPLSQVMGKCCVMFVKDYFRCQPINIDDKDVYVCESRYTSKGKSFKKIKIWPCLQNTPYIMRANLLPMTRVPSVFAKNRPNITVCDGKSGIAETGDEISDNDMLASMAEGSDCSVLDVPRPNVLCPSPADCPVEPGVQIQFYEQFTIPAGTFRVGDCCYVRTDQERNLICRIDRMWVDQDGNPYFHGPWYVQQAELPPTTIGSFYPQEVFLSSIEDTNPLLSICERCSVLDTTDYCTQRPTEFLEKDVYVCEIRYLEHEKKFEPLPECGLKKIHYQNPSIVADEIYRFRKPLVLTKANHQLPQVIEDPNHPLYQKLIAQQQQHSQQQGSMTSTIDPAQLIVSDSLLSSIHDDSTNDTVTGIAITPSTSIMPPPVVPSPAAAAAMAVSTTPMTVGIQMNVTPSSIATTNGQILTGTPVSTPIVTPTAVISASTTATPIASSGTNSKKKPATKRLVTGYIIFASEVRRSVVEANPECSFGDISRIIGNQWKLLTPEQKNEYEQRAAKQNAEVKEMVAAEKALQESLGPSSPAPQPGQPMENCVFECHWANKCDFQFEDAQDLFEHLTAEPNGHVWISYADTKDKEPGEFQCMFHGCGRVKKGATPFPSVQRLIRHCKEVHINKQIPKYVDPEKRSKNYVPSSKLAAAIINQNSQGSIMQTGPLGVIPKTGTTTTIVQGGQSFQTINIQHQPQFTLSQHQVATSTIPIMTQQGNQTIVTTHPHGTAQLVTTTGQAGQTFIAQHPLIATQSGQTIQGVLHHHPHQSTVVQSVPQSTIQIQASGQQIQLQAAQNAAQSVPTPIQKTSIGIQAKPAEPLFVQPPRTNRLVHSQAYMKYIENLKPDRRFISAWDRQLQAKRPENVYSTAKQNYAALSNWLENGPVTNHGTIENALWALRNFMHKDALNLAQNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8K5</accession>
    <name>A0A922I8K5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Motile sperm domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MOSPD2_2</name>
        <name evidence="3" type="ORF">DERF_000285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8K5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053012">
        <property type="entry name" value="ER-organelle_contact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384:SF1">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="116"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="330" mass="38906" checksum="BA432500DEB42525" modified="2023-02-22" version="1">MKLLRDLNVDQEILEQLRNKIYDYVINHQDVDIEDVRNRITPVFNSTNNSNNIDVNNNNDNDNENDDNNNNNNNNNNNNVSDWMLKRFIIAGHRNVDEGFEKFLDFYRFRHEYNVAKLTLANALPTEIFQLQAIQKPGIDKQDNQILVIRLKYYRKISQLDWLIKRALFYYFEQFDLDYEARRIDGVCIVIDCQEFGISNVDLDLLQFLVKQIPFGYYGLVRNVLVYELPFLLSYIVKIVESWLPTYIDKNGNKQKFFSVIGKKNIDEFIDNDQRPENLNGKLVLPVTLPAEAHPFAEFVKQFNGQIKDANVIKISQHINQMTKEQQQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8T4</accession>
    <name>A0A922I8T4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8T4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="116" mass="13750" checksum="2F6799B386F537AA" modified="2023-02-22" version="1">MKLTATLLLILTLSCSVFMIFKSFTTDFFWTIFILKTVDANPRFKRDNLDDVLNEAEELIERGEDVLEKLPDSDLKDEITEKLETMKYYKHELEYAYNPFKIAHFELELLTISSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9D4</accession>
    <name>A0A922I9D4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9D4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="81" mass="10098" checksum="34F74EACBA6D1B8D" modified="2023-02-22" version="1" fragment="single">LPIQFKDWIYAQGNNRWDEPESELEFYYQYNLFCKRMCIDTNEKIIFSTLFTYCLFCIIHDIELKNHHSLMLIDFFTYFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9E5</accession>
    <name>A0A922I9E5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_000160</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9E5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007366">
        <property type="term" value="P:periodic partitioning by pair rule gene"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000958">
        <property type="entry name" value="Odd skipped"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000254">
        <property type="entry name" value="Odd-skipped related transciption factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000318">
        <property type="entry name" value="Odd-skipped-related transciption factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000311">
        <property type="entry name" value="protein odd-skipped-related 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000148">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF0">
        <property type="entry name" value="PROTEIN BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0562">Pair-rule protein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="299"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="655"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="846"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="994"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="722"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="792"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="846"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="887"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="934"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="959"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="998"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9526041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1013" mass="115067" checksum="C5CA35DEA6CE0489" modified="2023-02-22" version="1">MVHATNLANPTAAAVSGHPHLPLGPTSRHHHHHNHTNSHSHHLGHLTNHNHSHQLHNLGQHHPLSPPVEIPGLFQGKQQPPTTAVPIVTTGQFSLTNGSNVGGVSHRNGSRSFVQTHSQPPPSSQPSSMNVTNRTSSMPPNLNDSLAIQNQLLTMLPNHLASFLPFLPASFGGNNVSNVVGNGQPSHPLSTMIANPKTNPFAPLSSPPFASSAADFLTPPPPPPTTTTPPTATTGQSNMNNFIRPIMPLPSSQQNRSLHSDIKTKEFKMNHNHHHHHPHQNGYNTINGRSKSLTNKIEKHNQHHHQAQDLSQNNQKSKSIHSNSKNDNNNVKMKSKFDFSRLAESATEGKKDTEEKTETKCRDNGPIVVTHKSFIANPNAFEHANKMLTLLNSGPFATLSQDGKSQTVNTASPFFASANFNPQTLLSTLQHQSPHLADYFSRKLARVNRISSRPKKEFICRYCQRRFTKSYNLLIHERTHTDERPYTCDICNKAFRRQDHLRDHRYIHSKEKPFKCTECGKGFCQSRTLAVHRILHMDDSPHKCPTCGRSFNQRSNLKTHLLTHTDIKPYNCTDCGKEFRRNCDLRRHMLTHSFGIVANENNNNNLTTTATMTNTNTTITNTNTNRLSVGEKSTTTNITMMNGEILIGANDINNHHHHHHQQQPNSQNPVRGRPPLHSSRQYYQQQQKKLESKSPTTISTLNVDDDDVDDDDDDDDIRIKKTPNSSKVLLNHQTPTPNDNDHHHRSSIMNTPNNKSDDDDDDDNNKIVRHNGGNDNHHHHNDDKQRQISTTKSKRQRKRRKHYQQNDDDDDNIEIDVDEQQQQHLIDGDDEIVVEMEEEMVDDEVMAEEEDEIDEVILEEEEKEDEEEEEEEEDEDIDIDVDDDDEKLWNEKKLNENDRERICAIMNAAVKAASSVQDRQQRRRQKSNIDRQNQRQSLTTENNGQHGKLKQQKQQQQQQKHDNINDNGDHLLAIDKNQHPSNVDDDILTTTIIKSTIDEYDDDDDDDDIDVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9Q8</accession>
    <name>A0A922I9Q8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Selenoprotein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_001023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the selenoprotein M/F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9Q8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.50">
        <property type="entry name" value="Sep15/SelM thioredoxin-like domain, active-site redox motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038219">
        <property type="entry name" value="Sep15/SelM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039992">
        <property type="entry name" value="Sep15_SelM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014912">
        <property type="entry name" value="Sep15_SelM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077">
        <property type="entry name" value="SELENOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077:SF6">
        <property type="entry name" value="SELENOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08806">
        <property type="entry name" value="Sep15_SelM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038116813" description="Selenoprotein F" evidence="7">
        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Selenoprotein F/M" evidence="8">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9526970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="145" mass="16855" checksum="015D9905C5B6D14E" modified="2023-02-22" version="1">MNPMYLFGCFMSVIITSIVGEKLTDNECNQLGYNPAELFCSRCLELTKFELDNLKDSCMKCCRQDDDSNSKKEYCECNIANFPQIKAFIRGDKSKKYSNLKIKFVRGILPILKLLNEHHDVVDELNIQKWDTDTIEEFLDQHLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAB5</accession>
    <name>A0A922IAB5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAB5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="6948" checksum="E8404E60114212C5" modified="2023-02-22" version="1">MFMFIYVASSDSIMFDFIDSDTATLLSSAISVETLAVRNISSNSTNCPIKFKLGEMMGLRDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAT6</accession>
    <name>A0A922IAT6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAT6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="84" mass="9549" checksum="8F1ECD9B34450891" modified="2023-02-22" version="1">MKIETDFSSLFQCNKGRQTKHDSIGFCTMLVFLAQTLIEIKYSFCVLQKKQPLLSPCSFRAKIDTVLTCATTRLSSLELYSMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBG6</accession>
    <name>A0A922IBG6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_001763</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBG6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="11">
        <location>
            <begin position="204"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="734"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1028"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1043"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9527758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1056" mass="121195" checksum="E05AD0B2268CF714" modified="2023-02-22" version="1">MYNNVSNNHHRLFIVDKSSGKHILIDTGSDVSIWPTSSKYLNVFNNNNKKSQRCNFQLFAHNGTRITAYGLERITIDLGFGQPFTYSFIIAESGYPIIGADFLSHFHLLPDLKNKLLIDPDNQRTVKAYTKSTDIYGVSTINQDIDPRVRELLSKFPSITRTKLTPEVKHSIRLTDENETVFAHPTRLDPIKLKAVKDELNKMLESGIIQTSSSSFASRIVVVPKANGQLRLCGDYRMLNRITIPDRYPIKHIEDFSQSLRNTKIFSTIDLLSAFHQIPVCEEDRFKTAITTPVGLYEYIRLPFGLRNAPSTFQRFIDQVFRELDFIYCYQDDLLIASENDQQHINHLEKVFNKLNEYGLTINIEKSKFFQTEVKFLAHIVDKNGIRISPDKLKAIDEFPQPDSLKSLKRFIGMANYYRRFIPHAAKIMSSLHSMSKTDFEWTDERLKAFNDIKAALREQITLSFIDPKAKLVIKADASDHAIGGCLEQITSDNKVEPLGFCSKKLRPEEFQLAPFDKELRAAHHCVKHFEHLIEGRQFTLYTDHKPLVNALLVRTNVKRSPMQMRLMSYILEFTSDIRHISGTDNVVADCLSRVEIEAITSSDPSSSSTESSSIEPISLQMIANEQHNQLEEMESYRTEFGPRIKLQRIDDQLILVHVDDKSPIRPVIPSSLHKRIFHLCHGHDHKSANKTRQIAADRYFWKSMNADIKQWCRTCQNCQKSKIHRHTIVPPKQIDIPKIRFSHINIDIVGPLPQSPISGNRYLLTCIDRFTRWPEAIPMSSISAENVANLFVTHWISRFGIPDVVTTDRGTQFESQLFHELTKLIGTKHIRTAAFNPRANGMIERFHRTLKSSIMATGQQWEQVLPMVLLGLRTVVKDDLQSSSAELVYGSQLTIPADLVTDHTDILPAHEFVRILKEHVAAAKSAITRPSRDSRCYIPDDLTTAEYVFLLKENRRTLERPYTGPFKVINRRDSTYEIETQNGLESVALHRLKPAYIERDDQIDLPRKRGRPAKKVQFAENLTEEFPIPARANKPDVQPAIIKRKRGRPRKVQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBM7</accession>
    <name>A0A922IBM7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_001129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBM7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="561"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="592"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="622"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="651"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="358"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="804"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="825"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="895"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="959"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9527085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="994" mass="111964" checksum="722E23D96CD04516" modified="2023-02-22" version="1">MTTKVSNSTGIDTVPVGPSSSSSSSSSSSRQQQHQHQQQSSQITDINLRHHKLLQNIVKILKMNNVLEEYRLVVQQIQQQCCCKRTRQTWERLNVLESKYKELNSDLNVVSTLNQQQQQQRATCSSSLNSIRRISNTQKINSHNMDDNHHNHGHQQRSQIIRRELIDQSSDQISSNKKIKLRHSSSIKMIPIRSSNNNNGDDSSHFIKDHHRSSNGSSDHHLQSPSTNKQQDTKTKNSMLRSFMVIDDEDDEDDDDDDDDDEVNLIEEEEILDDEEYDDDDAEEELDIEEYVALSEILEKENPDKFVKEIDGKNDLILVVRDVNTKEIICYECTVGDQCGFLSRDRTRMVLHIGKHYQQDAEAEEAMEDDDDDDDDDDDDDDEDNDNRKMSLNTSGSSLRRNQNRTNNVSERKNLIDISIIPVNSAADPITTTTSNSTSTSSDSSITLLPIAGSKNQDPQTSKLSSTSKFLNNQQQQQQQQQQQQQQRLTTINQPAQVSMNRPIQQATILIPIATTSAINNRTFSIASSAKQLSQLSPTTITSTINATQQSVTNHSNQKPIKCEWENCAFMCDQNYKLRTHIRQVHEKVRPYLCDWPGCFGAYKTRSNLASHRMVHTGERPFICDYPKCGAKFARKYDCERHRRIHSEKMYPCEWPGCGKRLCDPYNLERHMMVHKGELPYRCPISNCVRGFRELRYLRDHMVNSHKFLPDTNQLRMACATSSSLSSQSSSRIMSIIGYNLNEGSASGSISTPPTFTSSIGNDNSNSMGSTIATTMDSQDNNNVVVATSFVTAIVANNNSIVTTPSSLHNTTSINKSDDVKNSIKSDCGQQMAKNGNDMNLESKKSNTNNDDQQTKETSNSQQTTHKTRTISTRSSSKLIDVSNSNANDCHKTENDDDDDDGEQTDDKTDNDEEEEEEEKMVITKVKIEEPESPSPITEQQSTTSNEQRQRTPPPEPPTTRQKAAAAAAAASSSSSSSSSISTLNKRSSKRNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBN9</accession>
    <name>A0A922IBN9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside diphosphate kinase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NME7</name>
        <name evidence="1" type="ORF">DERF_002981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBN9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="441" mass="51995" checksum="EFA88BB503B7BDD3" modified="2023-02-22" version="1">MTVHGSYNSYILLKSGTSVGSQSCPKRMITTRSSSDKIAWSTCHPLCKCCNMRCSTLEQLKDHSILDRLTKSSEDVASFIRFNRIIQPIDIERFRELVADSKETELKIRLICCEYEYLCRLNSRTPSKISIENMKIMLNMKSSEQRQILLVKSYFRETVKMRSKAKKLIRRKLKEQQSTSELSTDLTGIFDSSHNDAQIRYGLWKNCLFSRFTKSPRLILQSGINSQLWGPTLAFDWHLPEQVLIENNSEKKFIANREQNIKKLADSIFTICNHNLKSFQSSFNVVHLNLTKDLPIRILPYLQKSLEQSLLDRTFFNYNHNSYQTFFGDKIVFYIDPYASKILTNEDLKIQQDLIFIFNPYSELKGLKLKFIENMFEYKKNESNGDDRIRFRRLPLHDLVVAPKQRYLILSFYIECLRQVIFDQIDWIEALYKNVPKKYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICT1</accession>
    <name>A0A922ICT1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICT1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="514" mass="59053" checksum="DB1FCD8293424C78" modified="2023-02-22" version="1">MNKPYVQQKSSTYIHIFLVANHKNDHITSLIAITLYIGILFIGLLFLIDIYSIFDWLADWLMATQSSSYHHINTHPKQIFNEHLFCWIATFKQQKQTVPPSPDAIIIGGNVCVNMKTSMENGDYHRQSDRSLSKMKSPTMDKVNSFEIIEEEPDADSCSDDNDDHTDGSDQQQKENTATLTDDDTDNPSISLFSNPDVRSSIRKLSLDQNSFSSSSNDSGSKIQSSNDEKPLLKTQQPSRLVKIPWSPQPQAPKVHLQVVNKIFSPPPPPSQPVIGVSQQKRHSILSWTRKRAQRFMSTFGQSLDQSIQTVQSFLSPPPEVVSRKINNHTTNTGISNNRVTSKTLNATSSSSSSSSYYRNLNYHLQLQQQQQQQRQQQRYVPKGDPFWYHKSYFNNSNQTNDDLLNNHTINNQSHGFNGKTQQSTTSQVHYPQMTHRTNHHYQLNGHHQHQHQQSLHNQQLHYHHPHQHQQIAQQPMIKNLSQNLDHFYYVYENGYIKKIMSLALNPDVIDFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ID20</accession>
    <name>A0A922ID20_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ID20"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="136"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="225" mass="24830" checksum="F5AC9D76AAC74FC9" modified="2023-02-22" version="1">MYPLQLTALAPQLRISFGTNIQIDSIREGSDVYMECHVKANPPVKEVVWLHEDRPIHSLMSGDPNMLPDDPTLPTLSSSSSLSMAIGSTVIMTNQSLVIQKVHRSHRGRYQCVAFNEQVAPSCKPGQKLQYGVSRNEQIRIRCEVDAEPSTDLTFRWTLNTSGSGETSVEWASFTVNATTSIATYRPESSLDYGTLSCLAQNSIGIQNKPCIYSVVPAETLYSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDD1</accession>
    <name>A0A922IDD1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2314"/>
            <end position="2368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2319"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2346"/>
            <end position="2368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2626" mass="297186" checksum="61FA371B71DA1B90" modified="2023-02-22" version="1">MEQPISHIEIPTTSAQPIMSNQTKQQQPTTTNGDFQMSSYQIPPNFNPGVSQYQPTNQLQLFTSATNNFPPQQPPPMSQYTTTAYSYVPLQQMQFQFPQVSMPITTGHDPNLTIVRPPPTNPIINRSQHTTAIKTPITTTISRTNTPVGDPNKQYQKEDEVSFINDTLNMASGLAGSISTIKKNQIIDALTRALRLLAENMELKEQLITASKRKRNDDDMDPRDVMMDDDNDFVTKTEMKQYFGDIKRSINSLYTVMHQHKNNDTTSNNNKQNKPVSFAEILKETRDTATPKHQTVVYIPENEDTAVTRQTLARLIQPAKEGIDMTDAKSLSKGKMIIDFKDQASKSKFDLLAKATKQLATEPPRKLTPTILLKGVRRDIDKKEIPTMLNSFNFPIAYYVETNNLDINKLVEVVSERKNFRSERLINYSLSVDPKIREIIINELNGKIILDYSLVHAEDASPLRQCFRCLGYNHKATMCQLKPEQQVCFHCGLQHKFDNCPNKTFPPTCVNCLKLVQYILKCFTEWQTKFNTCTMDKENRPIAQQEYIKIAQINCNKSPSALQQFLSFCDKLKIDIALISEPPIRKNIPNIDKKYRPMYATNLAISSISTIHQSSNNNSTFSANHVFSAPQVTNNNQMPSNQQMLNSQQVPNNNHMPRIVHHPPSSAQQVHYGLVPNNQQSHVQQIAAVHQSQIMQLNPSIINKQTHQHPIIPVRSCIVILNPLISPIIISSVSNVDFLVIEINNFVIASVYSQPVGPIDTTIKDLDNLTVYARDKRMLIGGDFNAKSSFWGPLNDDRGEQLLSAIIHNDLTVLNDGIKPTFDTTRGNQRLISYIDLTIVSQNILDNISEWSVRDDIYNSDHRPILTTINNADITSTASRTTVRWNTNNVDWPAWSAAVSDKLSEFNISDSEINIIDDQQQLDLTITMFTNVIQLCCDNFCTKYIDKRARSGNWHKDTQLQQIVTKQRQIYRKIRRCHNQLALQRYQQIYQQLRHQYRTHLQKLKSDAFNKDINGDGPVNCFQRVSRLIKNSGHMIFKTIEGTSDPVESTIKLVDTLFPNDDPNNDSDDQKSTRIYINRWLQKNNNLSAPPPITIQELHNAIIKFKDGKAPGYDGSLAKNSEKFMALASNDNVALISLDIRGAFDHAWHPSIIQRLIDYRTPKYLIKMMANYQKDRRICVNHGGVSCYKETNRGVVQGSMLGPLNWNIVINDFLTKNLGDDTRMQAYADDIAIVVSSKCKTYLPIKINNILKMAFEWGQKSKLTFSEAKTQIMYVTRRINRPIYSPVAMNNIVIKPVEQMKILGVIFDHRLDFRPHVHHAAHKAINTYRLVNGIARKTYGLSPQVLQLIHHSIIEPIITYGAVVTRRATRYQHVINFLRQLLKPLAQKATKAYRTAPIVATSAIADFPPFELLINFRATIVESRVTKCYNHLGVDIPVDIEEAQEPATKCAITFIVREPTAITPARIFIKSILTNRGIGTAFMAFINDNRLTTKSYRLPNYGTLQQADLFAIKMAIDWTRTNLGHRTTYIVTNNIGTVDRDSEHYRKLKQVARRTGKHRNRSYDYDHIHLKVVKKIEYRNMLSKWDDKYKNDRFGTNIKKICQHVGDARQFSKEINRFLTHTLTGHGQFGSYLARFGISNDIGCVCGFPVQDVPHLINDCPMSNLERRRHGTTNFAYRNTNNIGTTDHVQSNQATTTNNNKWRLSNVIVSNPAKLQSCLNPVLRNKWRLITLLQHHNYNNKIRSCINMVSQLSPQFSNTSVPTSFNPGLFYSQNAAATSAAPASFNFLPPTTNIATTATTTPITTSISRSATPVNNMPSANNNVEFLKETLKMASKLGGNITTARKEAVVDALNLALSLSQENNVLKEQLTNAYKRRRTDTDLCSRDDPMDDDDSNYVTKAELKSYLDDIKNSINNLSNIISKQSNKATSNKQNPPLTFAEIIKENKKSSTPKHQTVVFLPDNEDTLVTRQTLSKLIHPAKEGIAMTDAKSLSKGKMIINFKDKASKSKFESLAKATKKINTEPPRKLRPSIMLKGVRIEVKKEDIPSMFAAFNYPIAYYVETNKLDITKLMEVVSDRKNFRSEYLINYVISIDPAIRDLVINEMNGKVILDYALVHAEDMSPLRQCYRCYGFNHIANTCQLPPEQQICHHCALTHKYELCPNKACAPRCVNCRKTVLINHARFTSECYNVWQTKLNIITMNNQRQSRSQLDTTKIAQINCKSPSALNQFLNFCDKNKVDIAMITEPPIRKGVPNISRKFKPLYATNHYSSDHHPNTHQQNQLHVSVPNVQLPSSFQPYVQQVSAMQHVPSAGLGPINHSISNHRSASNNQQASVNQPNTNNQQVSSVLQPPLNQQPSNNPPSSTTQTPVRSCIIIFNPSLSPITISSVSNTDFITIEINNFVFASDYSQPPSELCLHLFTGGQPLSIVEITATSYANIAIFTDCHRTTRINRAVTGIARKSHGLSPQVLRMIYHSITEPILSYGALITGRAVKYQHIQKILRQMVTPMAQQAVKAYRSSSYISVTALADFPPIELFIGFRAAIATARTTGQYKYNDLPITVDINDDLNNNTTSKITTIIKEPSASPPFRIIIKSIKTTMGVGAAFMIFNNENIIGVKHYRLPPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDE0</accession>
    <name>A0A922IDE0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDE0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036904385" description="DUF19 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29758" checksum="5A22C3F9D59C5539" modified="2023-02-22" version="1">MMRLQTILLPLFFFLFGFSICAAKKSLLLDKPECTQKRLQEVDRNFLRLIAIGEFGRKFPEKHSDLPKFCKETNRLIDSMIKFISDCYPPDEQRIFKIYFFSAKRTVKPFCTKKRTKKLQQLLELGPCLNTIINQIDCLDQLTNKTRELIPYQIGRDKINYACCYYVDALKCAENVLNIQCMTNNAKDVILDLVRSIGGDMVNFACGDYTESTDRCDHIPPLPKNKFDKSVKVDKKLRSIAFAQIGMVESMEGFSAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEB3</accession>
    <name>A0A922IEB3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">METTL2A</name>
        <name evidence="6" type="ORF">DERF_003209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEB3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="5">
        <location>
            <begin position="102"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9529318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="291" mass="34627" checksum="4CC84A153EB63363" modified="2023-02-22" version="1">MDNDKRPKFGNRFLDEKSDIFTHNAWDNVMWDEDFKKDIVEKVASNSRDKVSDEKALEFETNAFKYWDNFYEKHENKFFKDRHWILTEFPELTPNETRKNILELGCGVGNTVFPLLEIDNHKSLFIYCCDFSEKAVKLVRDNSLYDENRCNAFVLDITGDWKSSPLIPQSLDIITMIFVLSAIDPKCQKQVILNMIPYLKPNGIILFRDYGQYDMAQIRFNKGRCIKDRFYVRGDGTRAYFFEENEVDLIFTETKILTKINLHVDRRLQVNRANKKKMYRVWIQGVFKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEG7</accession>
    <name>A0A922IEG7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcitonin gene-related peptide type 1 receptor-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_003856</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEG7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15260">
        <property type="entry name" value="7tmB1_NPR_B4_insect-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF32">
        <property type="entry name" value="DIURETIC HORMONE 31 RECEPTOR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02793">
        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="39"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="225"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="318"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="620"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="665"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9530011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="79364" checksum="F9598006863F8EE4" modified="2023-02-22" version="1">MTELRKLSINNADDDEINDEKIMTTTTTTINNNSKRNSETDNNFEIESTATTTTTTNCPADCDGITMWPETKRSNVHYIFCYEILKNLHERTAFSVVGGDGGNLISDETNENSENHHQNNDWTLLSDQNDFAHHNHHPRQQQQQQQQHHHNHHSSSSAVAAAKVSRYCNDDGIWESSANYSTCGLDNDKLFLLTTNQLQKIFEIRERMIHSKFTQNKESEQAFIDCIDNVLSLPPSNQLAKPFCERTFDGWTCFNDTPAGEVSYFSCPDFVYGFNPQNQAHKTCTKEGKWRVHHETHVPWTNYTSCVDIPDFHFRNMIIKLHIVGYSISLVALLISLTIFVSFKTLSSQTRIRIHKNLFVSFIINNFMWIVWYLVIRDGNILFENGFPCQALHVVLHYFLVCNYFWMFCEGLYLHTILVIAFVSEEKILKWFYMIGWAIPIIFVSAYATFRAFSSDTKNCWIDESPYLWILNIPVIISFVLNTFFLINIVRVLVTKLQAVNTADAHHTRKAVRATLILIPLLGLHFILTPFRPETNDSAARAYEIFSAIVLSLQGFCVSILFCYFNGEVLTVVKKKWNQFLLVHGYSSNNNNQRITSHHGTEISINLSDYEINENFHHHHHHHRNNILNNNGNNNNNNNNNNELMHLAEKNNNKNNGEEMDGNYSSSTSKSTTTTTTQQQQQQQQSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEK9</accession>
    <name>A0A922IEK9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEK9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="6826" checksum="C3D9784798A68459" modified="2023-02-22" version="1">MVGGHGSSGGGDGGVGGQSVSYYLDEENYELLLVEEEEEANLIMNPRDTYTDDDDDGSVVLRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEN8</accession>
    <name>A0A922IEN8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Large neutral amino acids transporter-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Y+L amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC7A6_1</name>
        <name evidence="11" type="ORF">DERF_002595</name>
        <name evidence="10" type="ORF">HUG17_10549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEN8"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF240">
        <property type="entry name" value="LD25378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7636579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9528675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="546" mass="60372" checksum="679F6B6D94F65D03" modified="2023-02-22" version="1">MTIILLSESNDHHQTPSYGTMDFHSDSSLARKRTIINDDDDSFDMQNNNIQRKKNGGSFMNNSNNNDSPFSSSSKNEQIALKKELGLMNGVAIIVGIIVGSGIFVSPRGVLQEAGSVGFSLIVWILCGVLSTIGALCYAELGTSIPESGGDYVYIQKAFGPLPSFLFLWVSILIIQPAGNAIAAMTFANYILQSIYPTCSPPANAVRLIAAIVIVLLIFINCFNVKWSTRVQDSFTFAKIIALLIIIGCGVMQFFNKDNANQIDQTLSYPNSFENTSTSPGHIALAFYSGLFSYAGWNYLNFVVEELRDPFRNLPRAIYISVPLVTLIYLLANIAYFTVLTPEEILTSNAVAVTFGDRILGSFAWIMPLSVALSTFGGLNGGIFASSRLFFVGARRGHLPDSLAMINVKYFTPMPSLVFLGLLSVLYLTTTQVYVLINYATFVESSSILASIGALLYLRYHEPERERPIKVHLALPILFFVICLFLVLLPFYVSPMEAGMGIIITLTGIPVYMLTIYWKSKPRTYNRFINGITIFIQKLFYCVSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFV0</accession>
    <name>A0A922IFV0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFV0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="389" mass="44629" checksum="A12BB505C04EBA4F" modified="2023-02-22" version="1">MRLNTCKAFYRTFKTLSNAHEVFGLFTTHRLLNPVLINQKSFVVMSTIADNSMKIIKIGTHNGTFHCDESLACFMIKKLPSFENGIIIRSRETNELNSCDIVVDVGGIYDPNSKRFDHHQKTFDKTLVDIFPAKNPKIGNIKLSSAGLIYAHYGHEILARILDWNKDEQRTDIIFDMVYENFVKEVDAIDNGINMYQGEPVYHIHTHLSQRVANLKPHWNEKETHEILYERFLKAVDLCGQEFVECVNYYGHAWYPARQIVMEAFNKRFEHDPSGRIVVLNVGLPWIQHLIQIESENNVDGQIAFAIFPDHDGWRIRAVPISESSFELRNPLKAEWRGLPSADICRISKIEGCIFVHSTGFIGGNQTIDGALQMARESLQCKKMKNSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG44</accession>
    <name>A0A922IG44_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">deoxyhypusine synthase</fullName>
            <ecNumber evidence="5">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_003951</name>
        <name evidence="9" type="ORF">HUG17_5795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="5"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG44"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7642748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9530121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="378" mass="42528" checksum="CF988F1EE2482ACA" modified="2023-02-22" version="1">MDDPMLKSIQEAVLKKTSISKKLQIESPNITDDSGGNILLQQKVGGYDFNKGINHSALLQTYLTTGFQATNFALAIKQIEAMLNARQEPFESDEYEDDPFIRRQTGCTIFLGYTSNIISSGIRETIRFLVQHRMVDCIVTTAGGIEEDIIKCLAPTYVGDFHLSGRQLRQNGINRIGNLLVPNDNYCLFEDWIIPILDEMLREQQTQKMIWTPSKMATRLGKEINNEESVLYWAYVNRIPIFCPALTDGSLGDMIYMHSFRNPGLILDIVGDIRRLNTISMKARQTGMIILGGGVIKHHICNANLMRNGADYAVFINTGQEFDGSDSGARPDEAISWGKIKMTANPIKLYCDVSLIFPLIVAETFAKYHHYSLSKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG72</accession>
    <name>A0A922IG72_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG72"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="142" mass="14446" checksum="8CEB244DA6B9E543" modified="2023-02-22" version="1">MDNTLNMIIINKVYALTYLPICLYTYEYANFVHTVGGGKNDAADCNCSGESGKNGSLPAEPGGGGTTELGGPVAVNDGVVVVDVVLLVQAVAVVVVDDGTGVETDVCGGIIDEDDVDDDGGCDCVVNVFIDVVVVALTTKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KTF3</accession>
    <name>A0A922KTF3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">General transcription factor 3C polypeptide 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GTF3C2</name>
        <name evidence="6" type="ORF">DERF_014629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KTF3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="174"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9493903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="959" mass="111127" checksum="43391F38C66D0449" modified="2023-02-22" version="1">MGRTTKDEPFGIAKADKYCCSLCGFVSIKLNECDHHILVEHQGQALINDDRPMTQAEIKQGYRRALSVLKMLNCTICSKTFRSFLGMVLHAEVCGKSEDELFRDCEICGKRLRIHSLALHLRSIHSNVDPSIQIVDNDIEMISQQEEVVEGKRGKKRNSALKAINKFRSLKLAGSDGEDDDKNKKSKKARLKNDDNDFSAKSSSSSSSSSSSSDEELEASISNETNDLNDKGNQDNKIQQETTKTLNDRDLDRIISIIVHHLIREDGNDNSDGFERTIIESVPVNRNGLFTCYNSLCPTQFKYRFELENHYRRCRWKKFWFRCFLNECQQNDRNRFNWLDVNVVEHFFHKHNELFNNAVKAEFDIFIKKKQLNDVVRSGPSSSRKPRYLKPLLEWHKQISLSLKANTVDNGNPMFSNMLPSHDDYRIIDENFQIQNCQSPYFKTTRTMDSGDNEMKKLSAFESIRLDNDNLMFNVGKCVSAISWCPLPFTTESTRFDCKSQFDRILMSEVNAKRDQYLVLATSDFDQILKNERSDQICLQLWNLGPLNQMKKGESEENIARLALNIDWTSYGDVLEMCWCPWGVSYEELKPSNERLQRLGLLAIASEDGHVRIISLPHPHQLNGSYKTTYLFQVKPVLVLQDRFPRYLNCNSIDWYPYAPFTMIVGAFNTGFACLWRLPIDNDDEKLLTKDKHLLPCDQNGNLKCQPLLSIRWINKYMYVCVSLNHSFIYHIHWDGLFRQLECRPCQKIMTYSPLWTNAMIQMAMVRKGSLIGFILLDRPIDSGADIRHTIISNATDDYTDMSLSPWMYTIAFGSECGRLCTTKMMKKPGYSEKSKSINYILYSTKLASIDQDLKNNLESIKKSITINEPLDLDYHIDDFFDKYFFIYEDSRKPDTILKGRTASTTIRLLTKNDLYRYYAINKCSWNPNLATYTWIFSCNKSGLCRLNNYPLINPKQMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVF9</accession>
    <name>A0A922KVF9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVF9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="574" mass="62522" checksum="F5F7E4C984A8A619" modified="2023-02-22" version="1">MSSIGNIDMMTLQQKPATNASALAINSATISANNNSMLNGNQSSSASNNNNNGINIGHQRLDDTRLELIRLRRTNDYFRETLATNEHLIRLLEGIRECLERRNDDLMEICTCKNFLRPEFSQELDSKDLLKDLYTQYYQAKHGLPVNLSLTNVSSDLSSSSSLSSSPPSSLSSSPTNKLTNGYHGRKSPSSLKLSYSDNKRTTPPRVDTTQSLSTSPSSTSKSSPTTTTKTNNIHNNNFHHAHMMHIPTSPCGSSSSASSSSLSLSPTTTTTNTSSCSTTTKQQPLYNQRDIESINVSSLSPSAAAILTISAALAEMANNGKSNGQKNRSSLYEQAKNATAVLQAAATSSSSSSSLVNISKNDSNLNSIQNDDSNSSHSLQDNLVMTTDGGTATNGCRSNYRNNIDDDDECCKENNENHNVDDDHHHNNADDDDDDEDQKYSINGKSLVIDDNSLSLENGINHGHRNNNHNNHDDNDDEEDDENVEIEIDDIVDDGDDVRKKVNGTIECSINKNEDESNDATTTTTTTTITADADTDTDIDNQTITRPTRLPILKSMLSPGDDDTMMTEEKIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVL9</accession>
    <name>A0A922KVL9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_016727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000010">
        <property type="protein sequence ID" value="KAH9490529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVL9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9490529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="193" mass="21560" checksum="3DD136463C50FB97" modified="2023-02-22" version="1">MKLRRSSSFDSLFNVSMLSTSSSSSTTTTSSSSSSRIPAVSSLIHDTNDEHQLSITTFTATNMDNNDDNKNGTATMMMTNDGNNENNVNNNNNGFNYYKTYCGRSMIDQTTQTPEDWRTNSCSIIASVVHHHPNGHNDQHYQQNHVLMVNNNDDDDDKHCHRLDASTTTTSTNTTMTTNEKKQQQQLPIILVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KW39</accession>
    <name>A0A922KW39_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">26S proteasome non-ATPase regulatory subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PSMD3</name>
        <name evidence="6" type="ORF">DERF_016061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KW39"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="229"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="430"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9491333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="465" mass="54038" checksum="0B33CFF6352346AF" modified="2023-02-22" version="1">MVENKKDIVEDVDMKSPGETSTNTDSSAIDEAAKKMERENFVLEELREHAKQIEKGVSAKEQRFILRVLRSLNATRKNINAAILRRVISIFYQSVPEQRQTLLAYIEEPMDTGTVLYLLDLHNYKSAITCSDSLMAKICKHNRRTLDVLAAKAYYYHTRCYELNGQLNETKSFFHSRLQTATLRNDYEGQAVLLNSLLRIYLHYNLYDQASKLVSKSTFPESASNNEWARFFYYLGRIKAIQLEYSEARKNLLQAIRKAPQQSAIGFKQIVHKLAITVDLLLGDIPERAIFRDPTLHRPLSPYFQLTQAVRTGNLKRFNEVLDKFGTKFQTDHTYTLIIRLRHNVIKTAIRMINQSYSRIYLKNVAEKLMLDNVEDAEYIVSKAIRDGVIEATIDHEREFMQSKETTDIYCTSEPLNAFNSLKAMRFPPRSYNKDLESAEDRREREQQDLEYAKEMADEEDDGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYY3</accession>
    <name>A0A922KYY3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trafficking protein particle complex subunit 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TRAPPC9</name>
        <name evidence="6" type="ORF">DERF_013691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="3">
        <location>
            <begin position="210"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="4">
        <location>
            <begin position="672"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="5">
        <location>
            <begin position="1284"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9497728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1414" mass="161385" checksum="0A2BA6012986E15E" modified="2023-02-22" version="1">MSVPDYDQFSEDHQSLLIVVKPIDNDWGDFQAHRKLIGLITVARSFNRNEIESISELHKTIHDTYNNTLFDSKCFIIQSFDSTESSSTAVEHESEYQTSNKIDGSSNDSINDNDTRVSGETIINNNNSEIDPLLDFDIGGQLYITSDHTCFTSRIIEESMNYSLPPLTDDVILTANRPRTHSRNKSLDSKLLSITTNNNNDSQNNVSQIPSNNLSSAATITHKRAHSSTTSLSTTTNNCDSPIFSHSSANEFIQYESNEQCCEQIKSKAKDFLNGLFWTLESKRLDKTREKKDKIPLLMAPCEKKDLVGLDTDTRSFRRKCLGRMQKHIADLSLMTGLPQESFLNYLTAIEYLKGVNDKLWLASAYEGLCSASLVLLFPKRWHHIHELRYRFFYTKGLVNDLLSRKDYEIARMELGQSMKQIAMEDSQFDQQIITNKTLMKSILTIDQFYEKYKEAASNYALYRGAAVLEFECSFKATKTLTFFRRYLKASDFIQNAVFISLNQPIEDQIERLLRISQLYEAIGFFRKAAFFKRFAALKSVSQAKNLDWEKCYFLLLPALYGYGLTLNPNEYDERLKLGNVNCSAIHVQLLQEIITTSLKMQKETLAIRHLSFMLQCLFTHITPSQRQEFATKLSSLASKCGEGSPVPLRLSNGATIPSVNFTKFPTVVYFKIEPLKPYLKLYKLRHKSLNNNDEENEYKYSGPFIYTPLQLNRSLEKNDYKNPDSVTKMNFYWAEGHTGCVSLSLHNYLPIELNISSIIMMTDGVAFEPKHDTSLKILPNSTCTNISLTGIPRSSGVLDILGYKIHTLGIKSDCRLKQLPNSKKLKLPSKFTVEIVPRLPLMCAQCMADDLNEEICLAKNIVTHKDRFTDCYIGNQNFISLFEGQCKSYRIKLTNISANNDELIDLINMKVIYPKHNKKTATTMANAQKSLIDIEWDIDSINNLLPFGPGLSVEFDINFTAKGDFILFKSNEENHHQNDKNKLFTNNESSNGGVGVGGGGGPSIQPKKLQVLGSKKLANFINELQSRKSSNDLSLSMNTNVNNPSMTSVAKPDDEMDFVEEISRPKLIELCLQLEYSGGPGLNSGFCRRVHIYFVIEIKSSILITHWDVIQAEQMDECYLVFDTLNATDQEINLIYSSNKEMLIEPKEKCRIPVSIKRCPLSLDDMNNDYDDDENVGDIIDMNQQNYCETIRKSSNNCKYTKSADFLTHIFPTDQKLEAILSQCRLHLLRQINLKWTMPNADIDGMVCVEKVPYSKQLLKSLLIPPIQSEIELNSMIFRSSFGEMNLKMGEHLSIVIRLFNNSDTNLQFLRLYLVYYQDYQNSTLTKTRNYNINDKMIVIGCESLCINELQTKKSYIHPCGLIFLYAGVYKLEICCLPEERYQQLLMEKGGTTNTTSRFDININNDMMMIMMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZC4</accession>
    <name>A0A922KZC4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZC4"/>
    <dbReference type="OrthoDB" id="6424180at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="221" mass="23960" checksum="53C18E3C6FE9E124" modified="2023-02-22" version="1">METTTISLGPARSIQSIPLSSSSSSPSSSSSSSSSSKQSIGQSWFSSFVIIIGIVLLLLGCGCGPSLQIAFAPKLITRFCYNSPNLSTINSQCVLCNYYMFDATVLGCTGSTALTMNITATQAFCVISQCLGQIRQQPVFLGRRKRDSNSNMIMEQLAPIQRYKDSNLDMINQSAISTLPVEYRIEKEVEADIVPDDDIDNDDDDDDDGYEISGKDLDSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZZ3</accession>
    <name>A0A922KZZ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_012284</name>
        <name evidence="7" type="ORF">HUG17_9042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZZ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="136"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7637938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9501436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="291" mass="34872" checksum="8534AA776CF0182F" modified="2023-02-22" version="1">MLLQAIDNIDHIFEPYRKSIENSYDDWFRKRFENDPLKRDLYLTFMSLFVVHWIVGAIFTMADYCALKWPSIRRYKIQPKELEKSFNLERFMNLATMATVNLFFCFMITTFIHFIPSLHRSATNVPTFTRFIFEFIISIIVVEAGFYYVHRGLHYPSFYKHVHKFHHEWQAPISLTILYVHPIEHFLVNVIPILAGPWILGSHPSFTWFWIVFSLVVGMSNHSGWYYIVNLLGPPLFHDFHHHLFIGNYGLMGLFDRIHRTDLYFRQSRYFQNYRIILGMVPKEIDDKKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0A2</accession>
    <name>A0A922L0A2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0A2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="657" mass="78829" checksum="07E2DCEFE8FED05E" modified="2023-02-22" version="1">MIISNVQNIPFINRELINFEWFPHTYDTCESTSCQKSTMNCSSILSKKFILKTIDIVMIDDQIYQFINNNDDDNDQYMNVIVYDIYNQISCEHDCYRRFYLDGGQMIHMKHIQELMNEYGMYNDYIVSNKKGLTHFLLYKKIDSKTKKILYNFDLHLMNVRLYERYSFLLHNNGITYRITSHEKHPSLFMVKSINKKINTFYWCIEDHMDYAYIWTRNTQSVKEHPTCSHDEHNYPLNFQPSYGFCFNNYIYLISYRWQRIAIVNVEALYSTGHHRISIIFFEEFFLCQFNEWTKPNFHWFPISQQSSGGKNHHGKQNPKHQQQQQQHHHHHKHHEFIKCRTFVNDLLKHTIGISMMNNRLYISIQDNLNQIMIWENFNETTINNIDHFTLGRYGYWVKITDSGFYTIWNKMSFVKQYDPHNNNSHHINPIAISMLNTTVNCDDEYDVGSKTYFAGHLLCQQFGQLIDLYWETTKQPECTKFELHYTNMTHNDDHQQQRQNNGHNYRFVEISGQNELYTIVMNANYDKIETLKSPVNVWRRKPGNTHIEYMGKLCWSIDGNEIRLINTGNNIDHNKFNVDYDDNECGITAYFTSTISYGFIGKINKLYLVSLKQFEMIIVDAKLLYDYHNQNNRWHTVRRINLHFSTIFKCQSKHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1B2</accession>
    <name>A0A922L1B2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009280</name>
        <name evidence="1" type="ORF">HUG17_7227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1B2"/>
    <dbReference type="OrthoDB" id="6503778at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7637021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="221" mass="24497" checksum="5ED20BB1A276A96D" modified="2023-02-22" version="1">MVIILAVSDAATIHHSMMNTDQLHNTKTIMTNSLAVETNPILNNPYLIDQKAEKRSGEFFPENFITTGKMATPDFDNIPSQFIGPNYAFGNSRLPLMASGLSGIDKSSVINNLPAKDETSNLFGSALKRYDMKKYLLKKILGNSHDLDEDIDDGFFSNKHLKRHGTAGVAAKVLGELIGIKIRESIEGFGKSFSEYAKDFTARNFVTMGQLFGRLFRISQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1B9</accession>
    <name>A0A922L1B9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 8">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CA14_2</name>
        <name evidence="12" type="ORF">DERF_009294</name>
        <name evidence="11" type="ORF">HUG17_7238</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1B9"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00326">
        <property type="entry name" value="alpha_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5039740184" description="Carbonic anhydrase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7637032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9510787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="320" mass="35872" checksum="5009EC9D4684D111" modified="2023-02-22" version="1">MAKLFAIIILLSCYYISTAIASDWSYSDQQSWANGENQCDGSSQSPIDINTQEVYYNGTLKLDFINYDHPLISYKVTNNGHSIQFDYTGDVGSAPAITGTVLNNEIFRLAQFHFHWGSAKHIGSEHKINGRAFPVELHLVHYNHAKHDTLSKALEARDGSVSVLAVFFEIKKMNPGFEVVADMIDKLQEATPEQSQFMRETITLQNLLPKNSEKLYRYHGSLTTPPCTEGLVWLILNQPNEIGRSQFEKFLGVIDSHSGEKIANNFRKIQPLNGRKVESSFKPDMVNKGFVHMATSSTIIVSLLMIFLSIVGISPLLSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1N0</accession>
    <name>A0A922L1N0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_011454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1N0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="326" mass="37910" checksum="DAB54EE24404C496" modified="2023-02-22" version="1">MSKNFLQKSSKQKLIRWSMYLLGSITIISSITCLMVDISDNDDAVRNDPLATSKTFANIILAIYMFSTVIPLIIHFSQPRLMYIVIFTNLSILFLIIRWAFSRWFHLEFSIATILNIPVSIAYIVHVYSETPKTTKSTISNILQIMMSDEIEINTTINTKKLSSSSSSKRKSSLQVMSKQRHQKSGSGSGKMVYYPIRYEKQTATLVGLHNNETGHYEFGIFFCESRPINIYISKLDSVEIKCRNLNQIKIIYPEEMATKSIRIEFLKPTDRKDFIESLMDARMIEMNQPTSITCCLLPCIAYYQRHYKFVRRRNHRIQAHRILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2Y9</accession>
    <name>A0A922L2Y9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">MED19</name>
        <name evidence="9" type="ORF">DERF_007288</name>
        <name evidence="8" type="ORF">HUG17_1712</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2Y9"/>
    <dbReference type="OrthoDB" id="10044050at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019403">
        <property type="entry name" value="Mediator_Med19_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536">
        <property type="entry name" value="LUNG CANCER METASTASIS-RELATED LCMR1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10278">
        <property type="entry name" value="Med19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7646174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9516553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="352" mass="38586" checksum="A55DB6DB100D1B76" modified="2023-02-22" version="1">MMSEIIRRPSEQCSPKTSPRGNRSPVVIPRQDSTGTLKTTISLGKTPAIVHSGPFYLMKELPPPSELTGSTNLLQYHNLEHSFNKFCGRKIKDQLSAFLPNLPGNIDIPASQDDSSLRKMIERPPITSIEIVPLNKQQLDSAFRLHVGPVPDQYRFMNQTVQRKKHKHKKSHKNRSGPNGPGDSPLGGPNDHHSAHLLSDSNMNSDLLSSLSSNRDRDSHEMMMKKHKKQKRHDDEKEQRRKKKKDKKKKKRHSPDSPPYDPNASSSLPIDDSPMMSSSVPSSVMIGGGPGTPSNPTGNNGLTSTSSNHQSSNASITGPQQPSSASSITTLQHSSSSLNNNINGSSSGRPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L348</accession>
    <name>A0A922L348_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L348"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="284" mass="32738" checksum="C576F70013C86294" modified="2023-02-22" version="1" fragment="single">MGALLMTKVSIQIFIQSPWIIAMGALSMTKVSIQIFIKLSWIIAMGALLVTKVSIQIFIQSPRITGYKQTEVCLSYQLSIMLDSRNSKSNLTVRNRENDKSKLTRPVQDSKFTIDKMATSPTNSELVVLGWICHFLDSELVVLGHGFFKSYLYRINVNLSSECECGGIDLNLNNFIEKIQFAMSKFFVLKNHIKLQRFISNTKIGRIITIHNTKHPIHIELIKCNKHYLTLNLEKHNSSLKIIFNKSKKRNKRKNISVLQNDHIPKLNVKIIRKRIIFNIFVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3F3</accession>
    <name>A0A922L3F3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">WNT5B_1</name>
        <name evidence="12" type="ORF">DERF_010335</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3F3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19337">
        <property type="entry name" value="Wnt_Wnt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF77">
        <property type="entry name" value="PROTEIN WNT-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9511911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="453" mass="50128" checksum="A7796E30822DEF8A" modified="2023-02-22" version="1">MHQVHATGGTWINLGMQGISLTNNELYPTDLSSYELNTLGNINSGSLSPNSYMLVNGDNNGGNNANNVLSTNNFGSSPTSTSTGSGSHNSIFGHNHYGMDSSEINSGIMGNVGGNPVPYGSNGNNNSNNNNNNNNNDYNYNYNKQQKKKLFCNELKGLSKGQTQLCNLYQDHIPHIGRGARLGINECQYQFKNQRWNCSTVDDSSVFGHVLNIASRESAFAHAISAAGVVYAIARACRDGQLSHCSCGRSARPKSLNQEWIWGGCGDNLDYGYRFSKSFIDVREKEKNLPKGSRELARKLMNLHNNEAGRRAVIRKTRATCKCHGVSGSCSVVTCWQQLLSFREVGDFLKDKYDGATEVRHPSFTRPTAEDLLYIDDSPDYCDHNNKTGAYGTQGRYCNRTSKGTDGCNLMCCGRGYNTQKVTVKERCNCKFHWCCYVECKTCTRTIDLYTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3T0</accession>
    <name>A0A922L3T0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Ubiquitin-conjugating enzyme E2 C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UBE2C</name>
        <name evidence="7" type="ORF">DERF_007598</name>
        <name evidence="6" type="ORF">HUG17_1962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3T0"/>
    <dbReference type="OrthoDB" id="10253686at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7646424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9516881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="167" mass="19320" checksum="0767A9AB49273A78" modified="2023-02-22" version="1">MSLTNLDIYSPKSKDMNVDRSAAVKRLQKELMELMVFGDKSISAFPDGENLFRWIATIDGPKDTVYDKLSYRMIIKFSAHYPFKAPNVKFLNHCFHPNISPMGDICLDILKENWSALYDVRTILLSIQSLLGEPNLDSPLDQQAARLWGHQDYRKYVLEKVKLEIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4C0</accession>
    <name>A0A922L4C0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G protein alpha-like subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpa2</name>
        <name evidence="7" type="ORF">DERF_010955</name>
        <name evidence="6" type="ORF">HUG17_9474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7642783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4C0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051427">
        <property type="term" value="F:hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000049">
        <property type="entry name" value="Glycoprotein hormone alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052680">
        <property type="entry name" value="Glyco_Hormone_Alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31129">
        <property type="entry name" value="GLYCOPROTEIN HORMONE ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31129:SF2">
        <property type="entry name" value="GLYCOPROTEIN HORMONE ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DAN" evidence="5">
        <location>
            <begin position="44"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7642783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9506214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="141" mass="15860" checksum="66951955C9CAE36C" modified="2023-02-22" version="1">MDHQHRSAWFEYSLWSSSHHQCWSSLVIIVTFVLISHCCSGSVWEQKGCHIVGHTQKIDIPGCINFELTSNACRGYCVSYAIPSNQETLLVNGKQMITSVGNCCAMTETEVMSVRVMCRNGPKDIKFKSATKCGCFHCKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4M0</accession>
    <name>A0A922L4M0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4M0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="205" mass="22888" checksum="387A132CD31489EA" modified="2023-02-22" version="1">MVKCFSLVIGGGGGGGGFVQFFFLGQTNKQTNNKYLIAQYPSIWPSIHPSMHRSNQEFDQTNHPLLTHPILTPLLVVDTRDERLLFPVLFLRPPPLLRFDRFSCCFVVPLETVVDLIVDFVDGGGGGESNAPDACIFSIALSTAICTRSSHSSRDLLRIRNLDTRNTMNNVNAMENIPITLTNMPIKRIFVNDSIESEFSDCKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4S9</accession>
    <name>A0A922L4S9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Toll-like receptor 2, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TLR2</name>
        <name evidence="16" type="ORF">DERF_010212</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4S9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF80">
        <property type="entry name" value="FI21465P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="300"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="650"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="725"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="693"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="725"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="763"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9511780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="788" mass="90349" checksum="9C03499DC95C5D36" modified="2023-02-22" version="1">MKFPKKNCRDLSGNQISIIKNTTFTRRLRHLKSLILTSNNIHTLQSDAFGNLTELTHLHLIGNQLEVIVDFVFHKNKKLRLLNLSYNPIRMIGLNAFNGLNGLIELDLRACQLIRLPARQFFPLNQLQILWLQQNRIWFINNDALVHLNNLDTLSLAHNQLNELNEAIFIDLIRLKSLSLAYNKLTFITENQLNQMTSLAKLDLSFNQIVTIQSHAFNNMLQLRSLALQGNRFQKLPQDIFNELKELTHIYFSDFRHCTYALNVRVCIPRGDGISSVQHLLDSVILRIAVWIVAMIALIGNCLVIIGRMMMHELNVVHSFFIKNLAMADLLMGIYLFIIAYYDIKFRNHYILYEEEWRMSWQCTFAGIISTISSESSVFILAIITIDRYLSVMHPFSIKRHSMSFAIGAMFMVWALSIILALLPLIAKRYFTNRFYGNNGVCLGLQLHDGTGIGYSTFLFCGVNSIVFLFIMHAYMKMSMAIMNSAIGLRTTQQHDRNIAKRCAFIVATDGICWLPIVLIKLAAISGIPINQDLYAWVAVFLLPVNSALNPVLYTLTTKLFKQHLNRFITHNFSSQNRHTPPMMDHSSGSSSFCSLNHNHINHIKENRDSDPSIHLNLKNNLATVDLHHYHHNNNQRYHHCQHHHCHHHHHHHHHNCHRTSTSSNNVTNNRSFPNRFNSKRSVMTILSDGSPAYTTGPSPTHTDQNIGGTMEIVRLEQLFENNKNDTSQTATDDNGSNVANNNHQQQQQQKNKITVNPLSLEKQNETTEIESGRKKDVAKLSDDHSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5H6</accession>
    <name>A0A922L5H6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Autophagy protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ATG7</name>
        <name evidence="4" type="ORF">DERF_004409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5H6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="2">
        <location>
            <begin position="449"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9520719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="861" mass="99884" checksum="722EA2AA9ECFED15" modified="2023-02-22" version="1">MATNNDLNSSNNNKKSIIEFLPFSTLIDSSFWFEIKRIKLDVLKLSTTPIDICPSFSVHTNIPGIVTLNYEAFESYDKLCTRREHTDLDEDLFYLNGQLIIYNTRDEFETTDKHVLINQQGKLIWDALNDETLCSKVDSSLEYYLARFFMIVYGDFKSYDFNFWNAYPSLSFPPHCFRLNSPNNIKWNHHFSYEQTNRLWQSFKNIPMKQRLFFVILLKPTNNNNNKTNDGHNNAVYFQNYDPEIVLFKNLWSLDFIQNLSNTKQQDVKIIFTFSDYSSYPNYPGWLLRNYLAYIHVRMAQLLKQYRNNKTILWFVQQCLYNTNLLIGSLSISRHYECESTLKPQWFDKISSRSFIHKIAMLPWNYKKISSDQYIQGFIEDVNKFYNSNSSDITDCSNDRINKTYVPNAVGWERNKKLNNRLLPNQVNCGNTLKPEIIATDALYLNLKLMKWRLVQNLELDKIKNTHCLLLGSGTLGCNVARTLVAWGINHITMVDNKNVSFSNPARQSLYTYQDAIGGVQSKAQAAAIALRLINPSIESKGIDLNIKMPGHLFEKSFEEEMNEIENLEKLIDQTDVVFLMTDTRESRWLPTVIATAKHKIIINVALGFDSFLVQRFGLRLRLNNSIDQQSKWLDIYSKQTKVYNQLFPDNNIEQTSSSTLQAPILLGTQLGCYFCNDVFAPSNSTKDRTLDQQCTVTRPGLSMIASGFAVELLMSILQHPAGPLAPSMTRFHEQYNIKKRMSELNDEQLIDMELLDVESLLGIIPHECRGFLSIYEQMTPSTPRLEYCIACSDKIIDKYRMDKRKFLYQAINDSKSLETITGIEIFHNVNDIDVKEFDIDDNSYDEDDNDDGNDKQFVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5Y4</accession>
    <name>A0A922L5Y4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_004172</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5Y4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037826462" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="88"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="414"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9520463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="668" mass="75730" checksum="6AE4850CB47EE9AD" modified="2023-02-22" version="1">MFFKFGIIFAIATVALARPEPEHVDFLSDEYIEHLNSLKTTWKAGRNFDRDTPMEQIRGLMGARLEIPAEMASRIPVVKHDHISDENIPENFDARKQWPNCKSIQQIRDQGSCGSCWAFGAVEAISDRICIASGQKTQVEISAEDLLTCCKSCGYGCRGGYPPMAWDYWVQSGLVSGGLYHDKNTCRPYTIEPCEHHVEHGSRPKCTGFVNTPACVRQCQSGYNGTYEQDRHYGQSAYHVHHDVQDIQKEIMTHGPVEATFLVYADFLSYKSGIYQRQTNSMVSGHAIKILGWGVENGTPYWLCANSWNTDWGEAGYFRVLRGRNEVSIESQIYAETIAANVTDVSINQIEDFLSDKFIDLLNQLNSTWKAGRNFDPKVTAKNLKCLQGSIEETMEEYQPKIRNRRQSIINEYLPDFFDARQKWPLCRTISLIPNQGQYCSSCWAVGVVQAINDRICIGSNQKINVEISAQDLLTCCKECTNNGEGCQGGFPSRGWRYWVTNGLVTGGQHGDTSTCQPMTIPPMNLATFIPYLQEPYIIPTPVCQQQCVNGKNYFKDKYYGLHYYRVSSDEQSIRREIFHHGPVEAHYRVYADFHHYKTGVYQHLLGTESVGHSIKIIGWGIENGIPYWLCANSWTPLWGGMGGFFKILRGQNHCGIESQVYGGWPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L614</accession>
    <name>A0A922L614_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L614"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="136" mass="15734" checksum="152BF625E4527416" modified="2023-02-22" version="1">MIIIVMIWEKVVSFFCITFWNECHKKSVKVSTSCMASIHSSMTILYFKNKFFPTLTTGSGVRPLFFDPLKNEILAILIFARGDLDQRVKIHLTTQCKFHMSWELKKIMGVILPQLIRFQGRIKIRSAAISHCVIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L740</accession>
    <name>A0A922L740_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L740"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037311631" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9515802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="17122" checksum="8066376FE7D4CE1A" modified="2023-02-22" version="1">MVFGTFFFLSSLLISIDDDDENGTIGIFFMRSTFFPPISRFSKLSTQYFSHKIYIQCRIYCRMVKRISLEFIITNFISYHGSFHSNMSVKLSLSPQFGSTRKEKKTTRREMKLFELNFIRNYARNTYEIQEKKSEHDNKNEKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAB5</accession>
    <name>A0A922LAB5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U4/U6 small nuclear ribonucleoprotein Prp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PRPF3_2</name>
        <name evidence="9" type="ORF">DERF_000581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAB5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9526497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="596" mass="69140" checksum="43502B9F30CDDFB1" modified="2023-02-22" version="1">MQLMIEQEFNHNKTMRPTPLILNAEGRTVDQTGKEVQLIQRMPTLKANIRAQKKEQFIKLNHEKQSSLSSTEQKFIDTRLESKAPVRARKTFRFHDKGTFESIGNKIRIKAQLELLQKDIAQKAKRTGISAAARLALLNSIVPKKQAKEDEIPSVEWWDSFIMKDSCYEECIQNTQPSQEKYDGITQLIEHPIQMKPPHEPSKPQFLPVFLTKKEQKKLRRQNRREAWKEKQEKIRLGLEPPPEPKLKISNMMRVLGQQAVQDPTKMEAHVREQMMRRQKAHEEANASRKLTSEQKKQKKIRKIKDTNTGVNVVVYRILDLNNPAKKFKVEANMKQLLMTGVVVIYKNVNVIVAEGGPKQQKKFKRLMLHRIKWSDDVVTHGDSNEPDSSNDSDLKRKRENKCLLVWEGSVKNRAFGEVKFKNSPNESFAREIFKNHGVEHYWDLAYKQDIDQYRDCFYLMTKTNGGLITRVDELKHIMRSLGMSPTEPELNDFFKQKGSDFQGKITFADLLDIMHIHSVREKIPAEILDGFRAMDPNHTGKISLADFSHLLCDCGEKLTTKEFQNLLKEANVRPGQTWINYEDFLEIIAAPAPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAM2</accession>
    <name>A0A922LAM2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAM2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="10001" checksum="42D7BD554A5A72AE" modified="2023-02-22" version="1">MEKLNIHSNQMSMMSSEEKRIYFNFNVMSSISFHRLSRDGERDGGVLGRLRDVERERDRLGVRLEYRRRGGDLKNGPKSISIQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAQ6</accession>
    <name>A0A922LAQ6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAQ6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8172" checksum="5EE82197765098DF" modified="2023-02-22" version="1">MFSSSSSSSKNIELNDELKPPAELMKMMIMLNDQNKESAKNRRSSSSYKLHNKLSAMFLSKYRHRMSNNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBW9</accession>
    <name>A0A922LBW9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_003942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037732730" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="333"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="829"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="1288"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="784"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="965"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9530108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1346" mass="150205" checksum="FC7FD335A8E9C7D6" modified="2023-02-22" version="1">MANFKYIVCSLFEFLLILTIIVNFIRAQDIDRENRCSSEGFFRDPNDCVKFYRCTRDEGADFFRVYEFACGPGTVFDPTISVCNHPGSSPPCENNGQQQQQQLPEYNAANQPQQPEQYSSQPQQQVPSTSSDSYPNQQTSPNNYYEQPSIIAAPYPQSQPSEQQQSPNNAGYPSSQQPGSTYNQQPNNYNPDEWSSAYGQPYSSDQSPTNQYPDHRDYLPEQFVNKNNNNQNHQQQQQPESPAPQQQQPESPAPQQQQPESPAPQQQQPESPAPQQQQPESPAPQQQQPESPAPQQQLPDQPEDDVEQQLTNMDEDEITPEDEDCNCKPVSSVFQCKQEGRFADRKNCKNFYRCTNDGGGFIADQFECDMGSAFDEDTGKCVPESQSKCKSDAGKPSPNGTKSKSKTSPQKESISEEPEPVEKSSDDQTTTAATSDETEATTTPASVDDDTKPTEPSEDSSESTESSTDSTESMDKTEPTTESSTSETSEQTDATTESSEKTESTEEPSTKPTTESADKTESTTPSADKSDETTTQPSTDKTETTTEPSDKTESTEESTEKTESTTKLSEMNTETTEPSSDETEATTEPSSDKTESTESNETESTTTPSSDDKSTESTTMEPDAEQQSTPESTEKTSDLMESPDEQKSEQAPDEEEEKPEDQTEQAPESEESPQEPQQPEQEAAQEQQQPEEMPESEDSPIEQESQDVPADEQIEPRAQAPATKTPANDNDLQQPIEQESETNYPNEPQYPQTSNDPSYMDRVQQQQPIEQSITDDNSLGGNINLQYNQPVQQQQQPLPQENENFNENDPYSGGEAANQFYPQPPSSDGIQCTKDGFFRHPNNCAAFYRCHEGTRFDFQCGPGTYFDERYSVCNWPNQAYPPCPSDGGQGDAPPTDQDQSQQLGQFPPQSDPNQYSSDSPFPYPPQEPTQQQKEEQPSQNDYPNQAEPIEQQKQEIQNDYPPPENYGGQQQPQQQQQPEQFQPMIQPPTKNPYPQEQQPQQQQQPEQFQPMMQPPTKNPYPQEQQQQQQPEQFQPMINHLPKIHIHRNNNLNLKNIKSPAKSPSQPVKSPNQSQSPAPVKSPKPSPLKSAPLKATPKAQAKSPTKSQKRSPAKSPAKPQGKTPPKSQAPKKSPVKSAPLKQARPPKPKSPAKQPAKPKSPPKSPAKSAPIKQSPKPKSPAKSPKSSPLKQNPKKNSPSPKSQQSKPPQKPKSQASPPKAKPKPQPKSPISPAKKARLQNEKPKSEQQISQQRKRQVSPARVLPLKPFAKPKPNQLRRQPKQINNQPTMFQCPTANGFFADPSDCSMFYRCADYRRFHFACPQGLFYDASLESCNWPNKIQPPCRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LC28</accession>
    <name>A0A922LC28_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LC28"/>
    <dbReference type="OrthoDB" id="6515568at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9530333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="298" mass="35338" checksum="13EF22143D97ED49" modified="2023-02-22" version="1">MSAISIKPKQSIHLLLNQTYNMNNPRLSIRLEESVQNDYDDDDDDDNVTVINNGNHHHQHHDSHHYQQKNNHRQKCINCDSLEKMLCLRDRTIMKLIEDRDQLKIKLTRTMNENIELTRQLLRYEGSSFRKNNNAATTNNQKDKNHQLIDNQKQQKELQFYHRRCQELEEQNQQMKFHLYSLRNVFVELSQQQNNDHHYDEHGNEDDDDVDNESYQDLPSSVSANKVENIVENDIGNHHQQQQKQLPSQNVQTDEHSTAKLMKDTATTTTITNDDTINRYDSIINEPIISNFDRWYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LC67</accession>
    <name>A0A922LC67_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell cycle checkpoint control protein rad9b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RAD9B_1</name>
        <name evidence="2" type="ORF">DERF_002738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LC67"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="632" mass="73755" checksum="7BAF05AD04AAED94" modified="2023-02-22" version="1">MNLVMHSRQGPYYWLGENIRRNKNPADIFTHHDGIDYVQKDKRNIFFAERFFLLYLQISYAQKPLFIGSEYLSMDSFVMSFPKHSPLLKPFNHQIKWLKKMGLFDIWMAKIFMTTKLANPKAYSQASRFRNPSNDIEWSQLKLYHIFYLDFLHNIFDHNSCRRDHQQRHKKQCLLYIIHSILIISKYIHLLIILLEFDYKLNVIIMKSTVIGLNLRTLSKTIRLMAKYSEEIKILVIDDFLILQSVNSDSTLFCQVTFEKNFFTSFQNDDDFECKVDIRSIGFVFRVASLDKMTNVCKIKMDNSMDHIIFHMECPNRIRRNYRIPIMKNNDQRCPVPLSQQLSNPTLRCSAYTMNELIKPFPLSTDEIIIWTFCDYLGFKTYFETNYEGPMTEFCVSSTYFRVIDSVYNYTNDMSIAFNLKELRSFLDFAMHRNQVISAYLQSDGKPIEFMFKNSDGCSASIMMGTIDLKNDSQPAIPPAFRITHQITDDSSSGSVLQNVSLDSRAISHEIPMNHSSMGKESIHHDVSTFIGNVTNSSLPNQSIGQQQLSLLDQREQSMDTASDHPIRDEFIPQNIDQNDDDNNIDIFKEIYQEIENSDNELTSSQSHFLFGDQSFEPCATLAPYSDYEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDB3</accession>
    <name>A0A922LDB3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDB3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="651"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="812"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="846" mass="100633" checksum="34C4E5169BEA7131" modified="2023-02-22" version="1">MFSGTVYNLKSRTYDKKRNIRPTISSRMMAIPNLDSCNDMDKHNNDNNNQFQLILDMGREYGFSIFGHKIDEEYSCHYSCWNGFYQNFRPIPSTSINHKICKLISKELCEHLRNVKIKLQSIRLIFLLNKTFYYFLHYIRLLLIDYQKHYHLMMIKLLTKKYSVIEWINEHLNDYHIKTAILIQKQQQQQQQQQQRQTFVWFTMETANSERLFEYHLNTKNLSDTKRKFLMEINKHEINNDPINQIYLSSYNKLDYDDDNDEIMLKNGQLLKMINFDLYLFQQQSYTPIKFCEYCSSSSSSLQFFPPLTTLPLKTFSDCPLHLCIWPMVDSIVYSYSTHQYLIFQGRYLFAYNVDNNQLQMSVNPLSFDVRIIQSFFKRKNVELFQIIYMIDNKLHRMEYNFKRKHATHQSVMDLRLDIDDKHYRLVTGLIDRNEEIYVFIFEKFNNDNDASGSTLLWNIYRRQNLIESKSIQTTMLPLTAMFINKYIHLLIGNQIFIMNTASLIELTMMMEQDRLNEMDCIRMDFFHYFDCHIHKKNDEQLIKSAKQQRIQMHKWFQYFIHNEISTIIDKNFIQNCRLFIDNGGNKKSIKDQLSTSKKVLENLNFHNNGIVVDFNQSLSMNLINYYNDDDNDDDDQRLSPQNDAEIYFPIYRFVSFGMVITLILCIVYICYYINRLICNGMKKCWKFLCCCCGRKNIDYNSNIRRQQQQQLKLQQQQQQQYQQQQQQYMPGIQQRWKELMVMKKFDELMIKSRTMSDTISTVVATEPSTTTSSSIITPPPPPLQPSTTTTPPPSLSSISSISTGMKMNDNSQSQEPKSTSTTTSTSTLSQWSKYRQQSIKRNGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HFL9</accession>
    <name>A0A922HFL9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015899</name>
        <name evidence="1" type="ORF">HUG17_3870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HFL9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7639837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="190" mass="22266" checksum="5A58F2292857BD6D" modified="2023-02-22" version="1">MDFKFPLNLERNQINSHFYFVINKLCESLIDTNQDNEPTIEPATKTICQILVHDLNDQCEEYRKEVLRHIKDIEFRKAIEHGIAFNSALNLPGNNNAHIIRMDPFSSMKIDTGVGEYFYLLLLYNEMHVIHQRTKSIMKNVPKLIAGEWMFIPNNRHLRLLNRDVDESYALIMYPSCIHLGFIACNLRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HJN7</accession>
    <name>A0A922HJN7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HJN7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6625" checksum="05F7D4829E00823D" modified="2023-02-22" version="1">MTISNDQIKDARHMMSDYCENVSFVLTTDPLVNVKVALNQCQVDDMSKYTDNIITGLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HL29</accession>
    <name>A0A922HL29_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADP-ribosylation factor-like protein 6-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARL6IP1</name>
        <name evidence="7" type="ORF">DERF_013045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HL29"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052114">
        <property type="entry name" value="ER_autophagy_membrane_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057282">
        <property type="entry name" value="RETREG1-3-like_RHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20952:SF0">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20952">
        <property type="entry name" value="ADP-RIBOSYLATION-LIKE FACTOR 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24456">
        <property type="entry name" value="RHD_RETREG1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="RETREG1-3/ARL6IP-like N-terminal reticulon-homology" evidence="6">
        <location>
            <begin position="65"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9497031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="164" mass="19537" checksum="5B22DED001AE696E" modified="2023-02-22" version="1">MHRALSCWSLFIFMCLWLVQVPIISKICFIGIIATLIDYFLPFLNEIFALPKWNDSAEQLFNDECRLIAETWINVKEFYQLFCSWKYTKTKLYYSTLLTTLMAIAWIGTQIHNLLLLYMATMFIVLYPGLSHYNMIEDFFLAIQRRLRSLFSKHRPMNPPKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HL35</accession>
    <name>A0A922HL35_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_016043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HL35"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9491315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="33" mass="3920" checksum="C14FFD214F6FD410" modified="2023-02-22" version="1">MVDDSTMRSYTISVKRVDNLENQREKKCEDVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNG8</accession>
    <name>A0A922HNG8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F-box only protein 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FBXO32</name>
        <name evidence="7" type="ORF">DERF_013921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNG8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040394">
        <property type="entry name" value="FBX25/32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13123:SF7">
        <property type="entry name" value="LD30288P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="363"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="621"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9497991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="670" mass="76663" checksum="18C17AB10C27335A" modified="2023-02-22" version="1">MPFIGQDWRSPGEVWIKTFEGWEPMKLLRKSHFVRHYRMDNDLDHHHHHHEDCLPSSSSSSPPSSSPSPNFDHYQEVVVLPPPPASSSSLSSSLDSNSSSSTTDYDSENELLVIGHHQHHIKSSDPVPVPGKRRHESGDSLTTATTPSTGSSSCSSSSSSSSSLMNGSSTTPEPISTTTKQQHDLNGFSIADIIQRLQRSSSQPIPIDILKESSEQIEIYHTQPYYRITLNPTREVQGSNIISDAFYKLDFCNAIRDIRRFAYVSKLLHLLITQNLTSLSGNATKALFWMLEEIAKQVASNKQNIHIIRKLLIELREIVDKYLCWGRPLGSTSLWEQHLRTMERICEMTDAIEIIPPEPGDGKPSWSELPEELIREILLRLSDYKDLERSAQACQRMNSLLNEEQHIWKQLVKYHFTKDQLRWALRMTITSESINFNNNPPINTTTTATTKHKSTPTMMNIEIDQNADPIIEQNKSIIIDWERLFHLLRKKFGLKEEYADCLFLMSLLSLSFLEENPDLTRQVLVTSPITGFKSTQHQYSTKYPSNSNNNENQQQQQQPLTAILRSRSLAFNHNNTNNNRRPPSGHRQQQQQQLPNGPVMVQNLPFFEHPLVIQRQRLNNHQQPDNNHDQNNEQNANAQQQQQQPSQTSFQKAPLHVPITPQAFLKFFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNQ7</accession>
    <name>A0A922HNQ7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNQ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="225" mass="24932" checksum="2F9D70B76DE524DC" modified="2023-02-22" version="1">MLLKSLQFYQSIRTILSLLIFGCWLSIILRSFIPIIVIDEIIVHYEYEQQRQNDDNKNDDDELKLQEMKDSMLLLTISFIIFTSIISIIGIIGVIGELTVHCLSRDNDDDERFVFHVDDWIGTGECVIIGGFIIGAAIETIPATGGLLLLLLSFDGCRICDVSVGLGLDACDICCCCCGGGCGSGGTCCWTIFVLCRNISNFSISTFEAQHICPLVEHLKCLFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP74</accession>
    <name>A0A922HP74_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Geranylgeranyl transferase type-1 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PGGT1B</name>
        <name evidence="9" type="ORF">DERF_012235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP74"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="15"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9501387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="353" mass="40442" checksum="1DFD0F6D1583FD81" modified="2023-02-22" version="1">MTIKIDERKRELLIKYMIKKFDKIFPIDDNNRLMLIFFLISGLDLINSLDELSDTKKCEIIDSIYEHQLHPENDSDISNGKFGFTCHRSAIGRTEYKYDYSNLSLTYCALISLIILGDQLDRVNRNAIISGIRHHQQNDGRFIQSLIEEESDIRIVYCAVAVCYILQDWSSVNRDTIIAHIKSCQNYENAFGQTIGAEAHAGSTFCAIASLELMGQLNDVYDQRKRQLIAEWCLHRQVTGFQGRPHKDPDTCYSFWVGATLTMLNSFQFIDDQLHSEFLSTTFDYDGGGFGKYPDTSSDVLHTYFGLAALSLRVYNRINTEMDVQSIYPALNISQRAYKHLCSIHSEWNGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP97</accession>
    <name>A0A922HP97_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acetylcholinesterase</fullName>
            <ecNumber evidence="2">3.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CES2</name>
        <name evidence="13" type="ORF">DERF_012107</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetylcholine + H2O = choline + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17561"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="3.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037416233" description="acetylcholinesterase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1564"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="12">
        <location>
            <begin position="29"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="12">
        <location>
            <begin position="627"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="9">
        <location>
            <position position="821"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="946"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9501249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1715" mass="198611" checksum="E7D6FBC4A3CA9E7E" modified="2023-02-22" version="1">MNSCKLLTIIVAIVLIIHQCLANDDYYVHVNTGLGEIVGKRLTIEQVNRYVDQFLGIPYAQPPIDEQRFRRPQPIVDGYDQKPLMALNWPSNCRQIAVPKFNEYSVYLNQTFQEDCLYLNIWSPSSLDNTMSSNDDQCDQQNCDNQQQQQQQKLRPVFVYFHGGCFLYGGSSLPLYDGRIFAAMTDALIVTVNFRLSTFGLLYADHMNDVNGNMVLWDQIMSLHWIRDNIQHFGGDPDQITIAGNSAGGWSVSAHILSPISRDLFKQAIIMSGSVQRQIMTAEKAKKFWLDNIRHTECANDQDENIDTAMIECLMKMTPEQLEMIPYYTAYLVVDGELIPEHPVEMLRKGNFKKNFNVIISTVDEETSGLLQFLAGYLMGEEIGQKFAFENADSLSTDDAIKVIAKLSGQYVTKSPSLDDISKVYFNGIRKDEDENVLRKMVGKAFGDVWLACPTIEFGQEMAKNSHKNDDIRVYQLYSTFKLNEKPFCPKWAGTCHMDDLFPMFGMPIQYPDHHHQRERDISREFLSLLHSFLRYGQPNQSEQPEWKPYSMIGHDNDRQLVAPSYELSNDYPTYQNYHLNLHTVQSEPTSSFDNGDNDGFEKIFHFLFSILSCLSLLEQTLANEAVQVSIESGKIIGKRQQDEQGRWYDQFLGIPYAIPPIGHRRFRRPEPIEKLTKQPYEALEWPSICLQSNPWENSSSYYNFNMDEDCLYMNVWSPKVDVHDENELRPVLVYIHGGGLIIGGSTIKHLEGRTLATMADVVVVNFNYRLSIFGLLYSDEVEHIKGNMAFWDQTLALEWVQQNIRYFGGNPKQVTIAGCSAGSWSISAHILSPISRNLYQNAIMMSGSIQNQVLSREDFIDLWLRRIRAAGCATDSDHSISQKLIDCLNQMNENELLKAIDADNLIFNGYTVVDGEFLPDHPIKMLRDGNHKKDFSLLLSTDKDEGSAFMQMFLTLLNRVDDGRKFSFVNPEPLDSLDEAKDLLATTIEPFLSKKYPVPTEQLAKIYFNGLNPKTDQPDLLRQTVGIAFGDMWLACPTINFGHHISHNDGHANVYQLYHSYYPIKTSEWCPKWSGACHGDDEFPLFGDPIRHPSKYNQRVRDISMELISFVHSFTRNGQPNQIEQPEWQSYFHVDDGESSQKVVVEPYYELSNEYRTHQTVLLLWPVAIVLARTFNEPKELELKSVHVLMRHGDRTPTHFYPNDPFQDVEKYWPEGLGELNDRGRLRIHFAGEYYRKIYDKFLRQTNGWPQHCLSSPAHRAQETAIFLNDTKIACEIYTDGKMLSTGEKCPLHDRVWLQQMNTKMVKNYLDSKRDYIDYLSTKTGQDYWSKESYTLRNMEFLATTLEIERDEYRLSVPDWVQNQTIIEQLNDMKHHAFWYDWQPHEIQKLRIGLLLNNITEHIRTLMMINDDDGGEKNDHQRFFLYSAHDVNQVILLQSLGLYEQIDRQPPSYSSGIVFEHYQTVSSSMTKETKHFIRIIYRQILNKNPILPNNQTMTFNVSDQILTMDYCHSSSQMKFNNIDDHNEFCPFEKFIKFTQPLLITNENDWYNECYESNHIVDHIMANQSMIIITLIFTIMMTKYYSRQEIRNSKILIIIPSLLDYSKHTCLTQSIRFLKIELRIVVVGQISVKIICITILSYTTLIGELMGIDQEIHCIVSTYKNKIDLEKKIRKIVIRTLITYNVHTIDTILILWPPPPPPWFKRFTSSQILAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPK8</accession>
    <name>A0A922HPK8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPK8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="92" mass="11602" checksum="F3DB546400202B7E" modified="2023-02-22" version="1">MAYEWLMSYNERRANRIINYIRHIHNGDERIILNRFDRDCLIMFHKIIDDLYRWSILIYRLFTINHEQLMEYKNIHGGMTIIDKERFENFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ68</accession>
    <name>A0A922HQ68_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Unconventional myosin-Ih</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MYO1H</name>
        <name evidence="11" type="ORF">DERF_012766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ68"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000004">
        <property type="entry name" value="Unconventional myosin ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF679">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="11"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="10">
        <location>
            <begin position="850"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="104"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9501960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1035" mass="122209" checksum="1FE9A1FE27DF06F4" modified="2023-02-22" version="1">MENLHQRDRVGVDDCVLIDDYRDCELFLNNLRKRFNEDIIYTCIGQVLISINPYRELPIYNDSYKQSYANFNFYQLSPHIFAIADASFRVMVDEARDQCILISGESGAGKTEASKKILEYLSSVTSRSEHHIKEINNKLLFSNPVLEAFGNAKTSHNNNSSRFGKYMDVEFDYLGHPLAGHINIYLLEKSRVVYQSKNEQNFHIFYLLLRGSSDQMLTEFSLRRDPQNYFYLNQNADDDYQVDCDQFDIIRNALKMFDFSDEDEQGMFAIIAAILHLGNVGFFDEDDGKTIISNMKPVMTISKLLQCDVELLKQALVNRTIEARDEMMMTGLTRDQAIYARDALAKAIYQRLFVWLVSRLNNSLHSKRRQDKRKTVMGLLDIYGFEIFERNNFEQFCINYCNEKLQQLFIELTLKQEQEEYRREQIEWEPVEYFNNQIICDLIEEKHRGIIAFLDEECLRPGDPTDLTFLAKLDENISGHPHYCTVRQYHSKNNRQNGMIGHEMHQFRITHYAGNVDYEIDGFIDKNNDLLYRDLKKTMCSSNHPIIKQLFGHDELSIHRRPTTTATQFRQSLSDLMSLLSSKQPWYIRCIKPNNFQRSKFFDDQIVRHQIQYLGLMENLRVRRAGFAYRRNFNDFLERYKCLCPKTWPYYRGSFRDGVQELVDHFGFKADEYRMGLTKIFIRSPQSLFRIEDAFQQHKHVLATRIQALYRGWHTKEQYKKIRKSVIALQTNIRRYLAIQNYHRRRHAAHQIRAFIKGFITRNGPPNQFNQKFVRQVKIHWLTTLSESLPSSIIKHRWQMAPICCRETSRLLCNMHKQWLARRYCLAITPKRKEVLQEKVLAESLFKNKKQSYVVSIPEPFESNRLDGRMDEMRRNIFEMKFKVDDEKTQYCTMVNKYDRRGYNCRPRMLVITNKRFYLLEVKKTTLAMKESLSLSMIKVVTSSHSDGLFIVRIPIMKKEKGDLILECHPRLIELLTKFSAFAGQDKLSIDDGHMIEHQMSNGKKGQIQFVDGHRYEIMKRKDGQLQVIATSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQH3</accession>
    <name>A0A922HQH3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQH3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6965" checksum="96D5AEDFD0008C75" modified="2023-02-22" version="1">MPVSSQDVSIPNTNFGACRQFCRLIIDRFKKNHKLNSMLGVVHIQHDDYGNNFFLELKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQW0</accession>
    <name>A0A922HQW0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sorting nexin-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SNX9_2</name>
        <name evidence="10" type="ORF">DERF_013281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQW0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06862">
        <property type="entry name" value="PX_SNX9_18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11763">
        <property type="entry name" value="SH3_SNX9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000004">
        <property type="entry name" value="Sorting nexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="222"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9497284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="570" mass="65744" checksum="53D8E2E5D47AEE4C" modified="2023-02-22" version="1">MKVIALYDFQAQPDTGEISITKDEMITVTRQDIGEGWWEGINSRGQKGLFPAEYVSPVADPIPATNDAWIAPSKDPKPTMLSFVNPTGTAMNNNNNNVESTSQPPQQFNNVDNNYDQADDADWGDDDWDDDDDSQTSEFTADYSPTNPPQNQIAPIHIGNNGNHHGNYGNKIGQPSIKKSINRFSHFVKSGGEDYILGLKTYNVNQNDLIHIVFDDDGQLKWAPTYFNVTVRVEEPTKRNFIAYRLTPSDTGIPVKRRYKHFDWLHERLQDKFTTIPIPSLPDKQISGRYQDDFIENRRKQLQSWVERICRHPVLCQSTVWKHFITCKDEKQWKNGKRRAEKDELVGGMFFLTIQIPENATIDMNTDPKVEQFARFIGKLDESMKNTYNLSQEMIKRYQSFYKREFSKMSSIFSTLSEAFETCPTKDGTANRALIQAVNNTSETYETIGKLFEKEDCRGFVPLSNLMHEYRGILTAWPEIYQVYKGSINKKREHKKARDEGRLDDKSLMGIEKRADVVTYATIAEMNHFEQERINDLNKVMREFLTGQLKLYQEIVVNIENALQMFPPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQX3</accession>
    <name>A0A922HQX3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQX3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="53" mass="5634" checksum="4DCA92AF02989A82" modified="2023-02-22" version="1">MNSVLHLADSSSSTSDISSSSGNAFFHISSSMSTWNPGTVFKMKYNDQGSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HR38</accession>
    <name>A0A922HR38_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HR38"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="950"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1071" mass="121717" checksum="78A724390545B306" modified="2023-02-22" version="1">MSSASTTNQQVRKPLVDRFSYLLRKCSSSTSTTTKAFPIINRRTLIGSGIAANLRIRDPANVDMIQAEIYQFHDPNTGEKSNELKPISMTKPTFVNDQEIFGDTLLKHMDRITFGTTTTTATEMKRHDFIFEIHKIQHSTTSTSTPRTTATMKSPSSSSSTSLISLNKSLTRNGTKSKMIQKQQQQKLELRVETLRKNHLVATTSLKASEIVNMKQQQQQHRPKQLSLNENLTTNSSNQQVTNNAMNNDDKWQYHDDQQVQEQQQQSSLMMDQSSKTMLSSFNERFYSESMPSIFVMATPSSIISTPFSQHNKRKWSTTTTTTAGHFDIDPSDDNETPKKSDQCNNNRLLPMSLLTLNLNLTPTTIDHERKTNLTTFKQQQQQQRIRIMDQTGVLGLGQKQREIVVKAHETNDGIFEIQINDVIDERITKPSFPSTSTIDNKQQHEQDNSNNVIINNDDDEEDPKTIKTLETKSIESLIENECQSPIITAENCHRRRSSNSFQLQIEPIEEIDTQPSTNDDDDEQQQQTSESIDLHENEEEKEVDDEEDDQKLEPRIEIVQDSQNSFDSETEEDEEQQVVEEFYRKRSKSLDLITTTTTTNMYNELVSFHQHQNDDKLNVMMSTKSCSSLSSSSLYSSSITTTTTTSFHSSILPSSSDTNDDDDVDNDNDLLTCLQSKNLNRTTTTPPSSTSINNYDRLSHNDDDDNDSNDHDHYAEEKNNNRLLLSFDSNRLLQLNDNDDCSPKQKQHFSIYTGLIRQLFQPKTPVADYVTYVDQLVEMFDISNECEQQQSPQQLLQQHPDYECTSDDDNADTDGDDYHKDNGTGGNNRDKKVKVSAAKKKIIKKRKNNIGEEKQPQEKTIQKYNLRKRVVNTKIFDSKLASQIKSLSLLVKTTLETSSPAKKESSSQAKDVEIVKIMNKRKKQTKKMKMKKRKIKAPKRNRMIEENSESSSSSESLSNASIKKQQLPTTISITSSIIKKGRNSDNNQKNSRYSLSSSSSSSSSTSTTAAIIRTTIIVEPQQGDEEEISKKLMINNKKKKKVNNRKILNNNNNNNRPNDVVKTSSSSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRR9</accession>
    <name>A0A922HRR9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasomal ubiquitin receptor ADRM1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ADRM1</name>
        <name evidence="12" type="ORF">DERF_010860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May function as a proteasomal ubiquitin receptor. May promote the deubiquitinating activity associated with the 26S proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRR9"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="11">
        <location>
            <begin position="15"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="10">
        <location>
            <begin position="290"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="208"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="410"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="412"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9506115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="448" mass="47840" checksum="49A7729C70610116" modified="2023-02-22" version="1">MMARPFFFGGNQSSQQSQYLVQMKAGKMVKNGNMVSPIKDRKGLLYLHQNAEDNLMHFCWKDRTSGQLEDDLIMFPDDAEFLKVPQCTTGRVFVLKFKTSSRRLFFWSQEPKDDKDDETVSKINEYINNPMAATNANRNSSSGVGGGSAGHGLMSANDLGLGSDEEFRNLFSNANMSAQQLMSMLDAGLAVGPHGGSSRLASLLGSVQNASNNSGSTTRSGTNSNGSSSTIAPAPPTQTPNTTPALASSETSNTTTGGNNSPAATTTTGLKLSDLQNIISGLSTTGDMNQSDNDLNVDLSTSINVEVLRPLLSNDDFMKRIGDMLPQQQSTALDSSSSSSATTTATKPLSEQFLSTVQSPQFQQALNSFSHALQSGQLGPLVQQFGLPESCVVAANKGNFEAFVKALQQVNKNDDDSSKDNNKKKDDGGNAGGKKDDKKFDDDSMALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRU0</accession>
    <name>A0A922HRU0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein C-ets-1, variant 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ETS1_2</name>
        <name evidence="2" type="ORF">DERF_012421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRU0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="192" mass="21476" checksum="FA8EB11C8743BC46" modified="2023-02-22" version="1">MTTKNSIHKNNSCSRIILKELNILPSDLDTEGITDGLTSQFFFSVSDSIFMITFLRIGFSLGPSSIHLFNLDEDGDDDDIIFSDLMENLIQKDVFNNSNDRTGNHEQQRKRPQSARQPSSSSTITKTTITAKTSMNEILLNQHQPELSSNKSNISNKRTIMARTNTATSLEAVFEEDDEDGPTDEPQNGRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRV8</accession>
    <name>A0A922HRV8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRV8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032053">
        <property type="term" value="P:ciliary basal body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903723">
        <property type="term" value="P:negative regulation of centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033207">
        <property type="entry name" value="CCP110"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13594">
        <property type="entry name" value="CENTRIOLAR COILED-COIL PROTEIN OF 110 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13594:SF1">
        <property type="entry name" value="CENTRIOLAR COILED-COIL PROTEIN OF 110 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="337" mass="39193" checksum="760E0A766A095F1C" modified="2023-02-22" version="1">MENPSIYYDHDDDDVQTNDNESFYSSALNSPNLSIRSSSPSSSSSTTTIIEQQNSFSAASDDDDSYESSIWHSFNNNQDNLDDKNDSIETLVPSFQKIQTNFPEKFRIIYEQLLFLQNDCFSRMEHYEQQLNELSRQLSDYRMEFSEKYQTIMTMFEQLSDAIIGNVHHQQSSSSSQTNQSSDIRAMVCLDDDGDDRIQHKLRRLPAIVRGYLVRRLLSTGKIRNLRRTIRDTSAILVNFKKNLQTNTDDGRLIVTEQDVLFHRQLCAQLEKSCHEFYRIFFQLSMAKRMELIRNDREHSLNRSDSITSQYSTSLSSSSSSVFQKINRKKILNKILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS63</accession>
    <name>A0A922HS63_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS63"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="121" mass="13727" checksum="B8D66354CEF62B7C" modified="2023-02-22" version="1" fragment="single">IVFLANDAMDSFDHSSNFCHKSGFIRLLASQLALIAAFECCTTSLNPRFNTKISPGHKIVDKTSSIWASFILALNGPETSRMKPSLVQTVNGLHNVVFLCMEYDFRWYILLELFLVQKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTE6</accession>
    <name>A0A922HTE6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTE6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="77" mass="9448" checksum="6E6FAAEE710C2CDC" modified="2023-02-22" version="1">MIDQYKQFLDVEWLASKYKTVIIMFDLIKSFETKLNIFNRDIFSNSYKYFPNTKNFFSESECHEKPIKESLTKNFQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTM3</accession>
    <name>A0A922HTM3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyridoxal kinase</fullName>
            <ecNumber evidence="5">2.7.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pyridoxine kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_011763</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyridoxal + ATP = pyridoxal 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17310"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10225"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyridoxamine + ATP = pyridoxamine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57761"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25105"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>pyridoxine + ATP = pyridoxine 5'-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25108"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16709"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:25109"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTM3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="15">
        <location>
            <begin position="96"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9507060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="305" mass="34307" checksum="ED390191E5615D97" modified="2023-02-22" version="1">MDIDNDHRVLSIQSHVVSGYCGNKSAVFPLQTLGFDVDFINSVQFSTHTGYPRWTGQVLNEQDIFELIDGLRHNNLLCKYTHLLSGYARSASFLKQCIRLLRNKIRSSKCFCDPVLGDDGRMYVPHELLSVYKEKIIPLADIICPNQFEAELLSGIKITGMKTALEAIDYLHSLGIKTVVISSTETGFDGTNEQLMTIGSSQLPGANNQGRQLCKLVIPRIPARFTGTGDLFAALFLAWFTKTKFDLKITMENVTATLNSIIRRTYEYANNKPNGLELPFNRELRIIQSRDDILEPKIQNSAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTT7</accession>
    <name>A0A922HTT7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Eukaryotic porin-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Voltage-dependent anion-selective channel protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">VDAC2</name>
        <name evidence="12" type="ORF">DERF_012615</name>
        <name evidence="11" type="ORF">HUG17_8803</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTT7"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000001">
        <property type="entry name" value="Voltage-dependent anion-selective channel protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7637699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9501802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="284" mass="31206" checksum="D2E7CB2C3A8EC313" modified="2023-02-22" version="1">MAPPCYSDLGKQARDIFSKNYHFGLVKLDVKTKTQNNVEFAVNGVSVNDTGRVNATLETKYFFKDWNCTLKEKWTTDNTILTELQFDDQFIKGSKLLFNGNIAPQSGKKSGAIKTALKGDCFHANADFDFDSLNNGTIVHGSLVLGQAGWLAGAQLSFNPQQGKLNKTNFAIGYLDKDFQVHTNVTDGKEFSGSLYQKIAHNLESAITISCASADNTPNFNIGCLYRMDEDTQIKARVNTKSNIGLALIRRLRPGITFTLNALIDGKNFNQGGHKMGMGIDLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU43</accession>
    <name>A0A922HU43_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">IVNS1ABP_2</name>
        <name evidence="5" type="ORF">DERF_012446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU43"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18502">
        <property type="entry name" value="BACK_NS1BP_IVNS1ABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18306">
        <property type="entry name" value="BTB_POZ_NS1BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF26">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="47"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="749"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9501611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="803" mass="90096" checksum="E05FB7B286B1F92A" modified="2023-02-22" version="1">MASIDWNDETIVIKDNKGQKIHLFNDDQYRSAMLENLNMLRKNRQFCDVILQIGTNHQDIHEIYAHKVVLSSSSTYLFEMFMNHEYQPNITNNGNMNGSLQSINTLNVPQQFRLVSATNFESDPEAFSLIIDYAYTATLKIPESKVREIYSIASRLKMTNVANKCGQIILSMLSAKNCLEIRNMKAVLNDASLLQSIDVFIRQHFEQIVESSSFIDSQLTQIKIEFLLNSEQEEHSINDRHMLNEVLVWIRSSLEHDVFDLDRFKDRNTMLMLHYDKTRNEIQDCCQIESNSPEESEMIEDYKKLNKRIALIRKSWSQDNIPNGLVKSSVPSSKPRQFLFTRSDSESSLCSSATDGIGGTGDDDVQDHQHDWKVLANCRLGSGNHTLVGLVSITAGQLCLLSITLRIKESTSKQNSLSESGQCDQDDITQQYCLIPPMSSARCAVGTANFKGKLFVCGGYDRGECLKTVELYDTVENRWQLLQPMQVPRGRFSVAVVDNCVYAIGGCDGHDELNSAEVYDKSQGEWKSIQSAPVARSNAGVCSMNGKIYVIGGWNGNRGMTRCDKYDPRNNQWTDMAPLNIGRYQTGCCSLDSSTIYSVGGCDSWSCWNTVEQYSSYTGQWRLVAPLQTARRGCGVASIGGKIFAVGGHDGIHALCSVEIYDPEEDQWTYGKSMTMARANVGVAVIDNRLYAVGGFNGKAFINTIEYFDMENDQWTTSVTILDSICSVNYLPKNGCDNDKQEEKVKKIDTNGGDSMKDTNNNNNNNNNQINSKNKFVKKMSGNTSFNQSLGSVMEVEETLKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU48</accession>
    <name>A0A922HU48_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU48"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="351" mass="42666" checksum="F4FF17F0FBCD0BD5" modified="2023-02-22" version="1">MPRSHGKLTTTSSSAQTIHPWYYVPGDKYSTEKRLAYKHESNSNRQIQNERINKYYRSTRLNPISISKWNQETKLLDNWDQNKSLVKHHRSMQNLTDPPFYIEDDIQIEFDRKQYDNHVQKVATIFRQYHQAAKDYRTNFIDTNMAVDYLLRQAELDELIEEKRNIFFSQWNRYVIQCNGGSNYNYQSDPLRQICFAIRELLHFYKSLVDDNLKRLNSIIDEKLFTATERNELGQLNDRCLQIIDMYLNLNESRDGHFQTMFCEEREKQWHEQCDRWSEEIQVWDTLFIKLFDSNYQLIYDRLDKFLQRQRSLLHDRLIKLEQLQHLIRDIEHDDRLQSILHIDIDQLLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUE3</accession>
    <name>A0A922HUE3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUE3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="170" mass="20097" checksum="469BD76AB13AB031" modified="2023-02-22" version="1">MYGEKITTTTTTTTSIILTIVLSLLLMVMTSKQQQSTISSSNITDKEFYTTTTTTTNDGYNIIQYVGNWLLPRLRKRINSIWKKRRQILMEHLSHLKYCYNPHYGDEELNLFNTDIDIHYVVEKFFNQSSIFDDIPKYQIPLRILSFVHNMVNLVHMIHECIHQTNEWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUJ4</accession>
    <name>A0A922HUJ4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009748</name>
        <name evidence="2" type="ORF">HUG17_7588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUJ4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7637382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="80" mass="9168" checksum="EA711B3094256FEE" modified="2023-02-22" version="1">MISECKIKCYAKGLAYFTIGFSLPYLLLSIKVKKTNPQLFRKLLIIPTIVAFHGLTYIPKDLDKCEQNQQQQKRMANSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUJ8</accession>
    <name>A0A922HUJ8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009257</name>
        <name evidence="2" type="ORF">HUG17_7207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUJ8"/>
    <dbReference type="OrthoDB" id="10599466at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7637001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9510749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="150" mass="16888" checksum="7899884DAB13CFD4" modified="2023-02-22" version="1">MAIKIVMDPKQQQNIEDSNIQFNQQQSYHVRNINDSYTIILARALLLFLLTFDIFLNAYVMMSLDRNDLMFGAATIIVGMVGQFAAITGQFGLQIADLLLHIFVVTDSLVVVLSFLMAQMSHNFMTKISFSLSMLSFLVGIFILIRNGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUS9</accession>
    <name>A0A922HUS9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaoptin-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Leucine Rich Repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GPRNNB1</name>
        <name evidence="5" type="ORF">DERF_012750</name>
        <name evidence="4" type="ORF">HUG17_8679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7637575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9501941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1481" mass="169277" checksum="0B6B964254DE6EE3" modified="2023-02-22" version="1">MIIVTIIESLELSPTSVNQRNENNDDDGGGGNNNRRRRLGQIYCDLNRMCLCQNYTAQYMDVTCVNVPFDSLPDLSRMMNNESNTFGPHLYRVRIHGARQLTRLNDRNSFARLITLASLSITNTRLSYVDGNVFRDLAISRTLTTLDLSYGHLVDIPIEALDHLEQLQWLSLKGNQIEVIKHRPLHRLQKLRTLLLNENRLFIIDDGSFSQLTSLEQIDFASNMIERVEGNPFPPSLRSLSISNCLLRKIPFDAIEPLAKLEMLQLQGNLIAHLSPFKLSVRRIQLIDLSHNLIGQLPDNLFANFQSPNRIADQNLKRNENNSTRFTTGHLGKYSSWNNDVDDSRTNLNESIDVDEELRIEQLYLDFNFIQSLGPDLFRSIRLDKLSISNNRLSSAGLSHTATFDGPTARSLKVLDVNYNLIDKYPIAFRELIGLRQLLMKNNRIQTIDPPDAFGASSKTLEVLDLSQNLIEQMPTAAFNTLRNLVKLNLHDNAISRLDSDDLVGWCGPRLKSLTLSKNNLVYLSADAFRACRQLNELRLGGNRLLQIQPVQLAQYMNRLQFLDLSSLANVDWTDTNTSETKFSHVKWLQFDFNELRWIPSHLIHLFPGIKHLDLQNNHIDSIAANRLSEAKHLQSVIVSYNHLTRIHRDSFARLAKLESLTLYFNRIERLDSGAFNELPRLQSLVLSRNQINYIEPGTFVNMANESNSLTLLLDGNRLECLSIDPFLQIRQPAAFSTNDANDDDNNVGDGDDGDQFALYLNVSNNQIKTLANCQNSAITTTNNINSNNNKNWANTAHHHHHHHRNQREQTLAVRVLDLSANQIEQLRPRFLKQFCGKTLSMLANHNLIRRLPLHLFGVGYCAQLQSLSLNHNYIVDLQLDPDDDDGDDVDDDNKTLTTTVDNNNNSRKASFVIQTLSLQHNLIKDLARFYRLFVRCSRLKSLHLNDNQIQWIPANLWDRTSIVTLNLANNRLTLDDDKGQSPIDRCFGIGTTLKYLDLSNNLLRTLPERIVYCDNLNELILSNNQIQSFDYATAIGTSKAARLISHLQRLDLDHNPLNIHVNGRKTFDWLSTDSPSLSVLRLSHVNNMATSLDELNLGELNLPYLHTLDLSGNNISHIASRLLSRSRNVRQLNLAINQLREVPKHIWKYVTRLQWLSLRNNPIDILDSLSFAGLKYLRHLDIRGLNLQYIDSRIFIYQSQILSLKISTYPQIRSFRLQDILSKCDSLQTIVVDVREPTLSHQIQWAFGGKLRELVITGHNLAVIVPDAFQGLNNANDLIVRITNTSVRHLPDSLLRYLADIRYITIDLRGNLLRTVSPSVFFTNIDNYRHSWKTWQSRQLLGGIILENNPLVCDCNLLWISQWMREVFTEMKSINVEAAIHAKAKLSLSRCARPSCYHHPERQQQQSSSKNVVLSNITSISSSVSIIDLRNEDLCNQNCQQEAMTVWQRSSSSSSSFHHYINSIFVLSITFRVMFIVAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV73</accession>
    <name>A0A922HV73_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NDUFS7</name>
        <name evidence="7" type="ORF">DERF_010915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV73"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="6">
        <location>
            <begin position="103"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9506173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="256" mass="29164" checksum="906035DE2BC1E5F7" modified="2023-02-22" version="1">MFIIASTIGSKSYRCVDATLKTLSASRSQCLLQLRKNDIHESRINANKQDAIEKQQSAVVERKRYSPFVNTSNTAEYVLARADDILNWGRKNSLWPLTFGLACCAVEMMHIAAPRYDMDRFGVVFRASPRQADVILVAGTLTNKMAPAIRRIYDQMLEPKWVISMGSCANGGGYYHYSYAVVRGCDRIIPVDIYVPGCPPTAEALFYGILQLQKKIKRQSLAQMWYLQNKKMKEILFGIQIQSFEDRNKETEKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWX8</accession>
    <name>A0A922HWX8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWX8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9695" checksum="55F95DD315611182" modified="2023-02-22" version="1">MYRFDDEFILFVTTDIGGQRVLRLYKIMAPLIIKNFLPQSLSYGFMGYSNCVGSLIRFEYNVNILIINMPGEHFCSFWIREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX56</accession>
    <name>A0A922HX56_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX56"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9627" checksum="61D7E5F7FB8CECAB" modified="2023-02-22" version="1" fragment="single">MHIGDKRSITLGLDRELFGVRRIWFTKESGSPRYESLYKIRLGFITYIEVVKQMLKVGSIKCFMPQTAIPNLKFVYIDIELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXD7</accession>
    <name>A0A922HXD7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glutaryl-CoA dehydrogenase (ETF)</fullName>
            <ecNumber evidence="11">1.3.8.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TYW5</name>
        <name evidence="18" type="ORF">DERF_007168</name>
        <name evidence="17" type="ORF">HUG17_1624</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="11"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXD7"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="16">
        <location>
            <begin position="50"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="15">
        <location>
            <begin position="165"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="14">
        <location>
            <begin position="276"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7646086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9516429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="423" mass="47367" checksum="1BF2189705965725" modified="2023-02-22" version="1">MLMNRFHTLRHGFDVKFVKNLFQKQNLCTTTIVHEKFDWQDPFRIYDELTSEEREIKDQMRYYCTKQLMPRILQANRNEHFDTNILKEMGALGALGPTLEGYGCANVSSVAYGLITYEIERVDSGYRSSVSVQSSLVMYPIYAFGSKEQKDKYLPKLAKGELIGCFGLTEPNHGSDPSGMETNAKYDPSSKTYILNGTKTWITNAPVADIFVVWAKCDNKIRGFILEKGMKGLSAPKIEGKFSLRASATGMIIMEDIRVPEENILPKAEGLKGPFMCLTNARFGISWGAMGAATSCFETARNYVLDRNQFGKPLASNQIIQLKLADMLTEINLSLLSSLHLGRLKDKNMLQPEMVSLAKRNSAGKALAIARVCRDMLGGNGISDEYHVIRHMMNLEAVNTYEGTHDIHALILGRSITGIQAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ97</accession>
    <name>A0A922HZ97_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-protein coupled receptors family 2 profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_006874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ97"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="2">
        <location>
            <begin position="167"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9516112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="271" mass="29774" checksum="4FD412C421D88538" modified="2023-02-22" version="1">MIQDSRKASFNTRNWSKIVNDENNVSQTLNDSIVIDQVFSSVSMSLSSSTPAAPAMNNGNNNDRQDVDRPSSSLWTTRILTNNNDTVSIQCSQLFTNSAADLAVNDTSIMVNVTNIANITTNTGGASFKFGQLSQQLSNQSQLLFNETWLFSNLAANVHEDGINATSSANSIVMSENSSSFYCDTVWDGFYCWPMTASGTILMHSCRDIFDSVGELPKDQIDESTYNNGQSEICGSELSSQEIFIMIVDMMFDNACNLMMILPGEEMVSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZA9</accession>
    <name>A0A922HZA9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZA9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7308" checksum="CB592B47F8281E35" modified="2023-02-22" version="1">MGKKTERYLGIYRLVKFTVAITFSFCVVRKNLFGHRLSNARSTGIWWNIGGLGFRTEFTTNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZD4</accession>
    <name>A0A922HZD4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZD4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9515837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="93" mass="10974" checksum="6DCC4E1809F549C6" modified="2023-02-22" version="1">MNVQIHNEFVHWLLTNGQHLDSMSLSIQFINVSCLAKSSAKEKKIVPDLNKKKQDKRNSYQIDSNQKKLFTFHSISNYNEMFVRCKLYQIIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I094</accession>
    <name>A0A922I094_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TXNDC15</name>
        <name evidence="4" type="ORF">DERF_007393</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I094"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042418">
        <property type="entry name" value="TXNDC15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14684">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14684:SF2">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9516667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="231" mass="27038" checksum="0DB2D734F6531537" modified="2023-02-22" version="1">MNHSSNENNYPEEKTSTIDNETATTSNMTTSSNETGQCAIMIFYYNWCRFSAAAAPQFNALGRLYPQMYVMAIDAYYHYSITIRFGVSGVPSMYFLYNGRAVAKYNRTDITMDGLVEFIRSLTSLEPIKPNVTDHHEVEEINNDEENVNNGNKTFSYDRIFWNITDNDRNGPLVIHLENQQNYLLIFCWKFCLIVLFYHFFRSNLFAMIKDHVRGMWNEWAQTVQHHEHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A922I0J5_DERFA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="2" type="ORF">HUG17_2248</name>
    </gene>
    <organism evidence="3 4">
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        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0J5"/>
    <dbReference type="OrthoDB" id="549243at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="219"/>
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        </location>
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            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7646710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="233" mass="26419" checksum="E5791F874138CA4E" modified="2023-02-22" version="1">MEIDEDCNSNVFKKPTTTGLSFQNFVRPTSHTTSATISSSSSQTATTTSFSQMNTPSRSSHCRRGSSGIFFNTMFCMSHHFRHLKRLHMESMEGLNIIKQPPARAVFRSSLPATPIATPIYRESFPFFTEQTLMERLCRTPSPRRSYSRNSSQMDTSECEMQQPQHQHQPMEICSPTTIDEESLSISSNSASSPNKERPMDEKQNSIDNTTTTDIQSSLNDIYYKISDQFNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0T0</accession>
    <name>A0A922I0T0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cyanamide hydratase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Rings lost / dna-damage inducible protein ddi1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DDI2</name>
        <name evidence="13" type="ORF">DERF_008075</name>
        <name evidence="12" type="ORF">HUG17_2337</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0T0"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA damage inducible 1 homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057273">
        <property type="entry name" value="Ddi1/2_HDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24669">
        <property type="entry name" value="Ddi2_HDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
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    </dbReference>
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        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="10">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="386"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7646799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9517399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="452" mass="50369" checksum="C933EADDB0E78DB6" modified="2023-02-22" version="1">MKLTITTLTDLIIHLDVSGDMELENFKALCSLETNIDSMNMSIFFNGKLLQESNKTLSFYGVQDGDMLLVKDGRGGGGGQTMMNNAGFLGQQQQQQQQLPQLDFSSIQVPNHLVQNERREAENIFATLRSNPEQVATLRVNNPRLAEAFDKGIEEFAKTLRIQQEARAKEDQRRIRMLLADPFDSEAQRMIAEEIRRQQIDSNMETAMEYLPESFAEVAMLYINCKVNGFPIKAFVDSGAQSTIMSKACAERCNILRLIDNRWSGIARGVGTQRILGKIHLVQLEINGVFVPCSFTILEHQPMDMLLGLDMLRRYQCSIDLKSNVLRIGTTGTETPFLSESEIPKFARLNMNEDLAQDDVQKAIQESLKESSPMTNSSGGSAQTPSTSGHQSRSGSNSSTGSRHSEADIQELVSMGFKREQVIIELDTFNGDKNQAIAALFAKSIIVPDNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0Z1</accession>
    <name>A0A922I0Z1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0Z1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="53" mass="6098" checksum="7276A209D78E5DA0" modified="2023-02-22" version="1">MLEEDKSNGCNMNGFFFGSKMHLPFRMADGLGKNGSNFEILKQKKMDEQMDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I130</accession>
    <name>A0A922I130_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">eat-18</name>
        <name evidence="6" type="ORF">DERF_004255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053207">
        <property type="entry name" value="Non-NMDA_GluR_Accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537:SF6">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47537">
        <property type="entry name" value="CUBILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="918"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="84"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="268"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="411"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="546"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="685"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="840"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1221"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1343"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1426"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="843"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1227"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1267"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1360"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1387"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1434"/>
            <end position="1444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9520552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1450" mass="161144" checksum="4BE695257D445872" modified="2023-02-22" version="1">MTTTINGLMIQSITMKSKSQSKSSSLNMKSLLAAAFMFYQVMVICLLSFAYASPSSSMDDNQFFLPSHHYDIVHSTTFSSSTDCDQVFISTTLNITHGTRNGTFVGPSFMIPMPATTVSSIISSINDSVGDQSSSVNPLLGSNNESNRYTRQCIYTFIAGPYERVRVSFTKFSLRSELPECLDEYVDVYAELKNPDSDLLSTPFGGRYCDLVIPHDRISLFQTIVISFYTAKLMDGTILNGSDIFEGTYEFVNATPYVAGTPMPNEICSYTIYSEVRREGEFMSPTYPGVYPKNITCYYLFKGVKGQRVKLEFMDFDLFYGGSHCPYDYVKIYDGETTRAPLINTYCGQQRQLFVFSSGINLLVQFTTLKRISSVNQNRGFSGYYEFSEKFVNLGFILNNENSEHIRGTECDQKIFSRKESNGTIYAPNYPFLYHSNIMCKYFLYGLQDAQNLERINFHFEMLQIPTKDVNECTDAYVRLYTQLQAMDEFDYVFCGETIPPPVVSDGPLLLVVFNSGSTQGQGFKAHYWFETDFKIMGTQASPGQCHFSYVSSGSKSGEFNSPRHPSNYPSNTYCIFEFFGEPDEQVKLVFNQFKFSDAEVSSLSIPGYNEKCTHDWLEVYSVESGSGREQFYGRYCGFTAPGPILTETGVSQIKVIVNTDENEVSSGFSATYRFDRASDRVQDCGGNFTNLENGIIQTPNYPNNYPATMQVCNWFITVRSGSKVLLYFDEFSVEGDPPNRGCPGAIVRVWPDLNQKSIELCGEKLNLRDKQYISDNNVMRITFLTAQKAVGALGFSAIWTEIDMPSDNNDVRVKNMTAFGPCMASTAISNPSTNQQQELIQSTSSLSSSSSSSSSSSLDIPINTMPYQCQKHGYCISGKLHCNGVQNCGFDDDSDESDCIHEVKINIVELVGGMTGLLMFIFFAIGIICLTIILIINWYRRSSGDEKNVGHIIDKTCQHYFAHPTAPDYSTYYQSDMATTMGIGTPHRLIDVMTVSSSSTTPGATGTGGGGNHNQMIKNVRWPSVSNSADSGHVTTAVTSEQPDSMFMETTNPANTITDEPIGDPNSPPIPPPPPPPMNRSLLNLRQSSLINFNQYGDNIGTNPTSTNCGTFKSDVNAGTGHHAHYQSSTLARNNFTASANGNNNNRTTMTMTMNRSMSRQTDSRISTFTAAASTPYTPYCTLPDGGGSSKLSIQQKQQMHCPSQSTIANRNNRISSIHHHHDNSRQNTSPGNTHQIESMLPPMDSLDSGCGAGQLSSRATKITIDDDDDNDVMNDDDHEDNDNGIDGDDDTMNNNMMLLMDVDNNSLLGNKDATGNGDYLMMTDHEERTLLRSLNNNHNYGKSDALATNGEESDSIHETQPSISVSSLRKYQISRLQNTGKNTLSTSSESKQSQQSSSHPPSTWHHPTDVFTIATPNANYHLHQHQHEQQHGHHQHHHHHHSSLIVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I194</accession>
    <name>A0A922I194_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sarcalumenin-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_008862</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I194"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051943">
        <property type="entry name" value="TRAFAC_Dynamin-like_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43681:SF1">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43681">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036702295" description="Sarcalumenin-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="4">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin N-terminal" evidence="3">
        <location>
            <begin position="252"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9518271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="69709" checksum="AAC2DC5D6E7064C5" modified="2023-02-22" version="1">MKILHSLATLLFVLILLIQLDLNPIVEATDGSSKSVSKATKGLQKVKCKEKVDEALRQYFKDEDDDDNDDNDDVDDDDADDGNESDEDALENDRTDNQDYGDDDNDEDNDDDDDDDQSGEKASDNDSNDDDDDDDSKESAHENEDDDDEEKNQVKKASVNKKSSQNDHDDDEDDDENSDQPRRSRAHIDDILKVYEIGSQDDNAEQNLIQSIFRDVKRVYESTVKPLETIYKYRQITTRLITDSEIFSKPMILFLGGKSTGKSSLVNYLLGIDGTSWQIPTGAASQTKFSILTYGDNYTHLSPIELAADFTFSSLQRFGEQFIADYIDARRLPINILQKMVIVDSPGLIDMVPTAMAKQTIDNDVYQWFIDRSDVIYIVIDVSQLHLSTSLRALLDQLKGREVRFIIAKADMASHSQIISMFGQLLWVLSPIMSHERPPMVYALSTLPQDNFDEFVDSQETSWLKDLSQQLSGISRIESHIAEVRRHAVRVRNHAKLIDCYLSTFYKNKGLFTFGSSSRQLAADIAENPHQYRIYSGAFMGQLQNVSRYDLPDPGVYREFFRSNPLIDFKPLTSTCSYFRGCPIDRLDVAIAYDLPELVGKYKKLTKTKFEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2S2</accession>
    <name>A0A922I2S2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2S2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9518047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="90" mass="10455" checksum="33101008F58F32E0" modified="2023-02-22" version="1">MIKNQTYCKEFVIVTILIFTCIATWCSCLIIIHFIIEILSDRCGYMHVNKTSGSGKEINNRRIFCLLMFQFPNIEVNTNAAFQIPMILIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2T5</accession>
    <name>A0A922I2T5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitotic cohesin complex, non-SMC subunit Rad21 (Kleisin)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rad21</name>
        <name evidence="9" type="ORF">DERF_005112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2T5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21792">
        <property type="entry name" value="Rad21_Rec8_M_NXP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049589">
        <property type="entry name" value="NXP1_M-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="7">
        <location>
            <begin position="700"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="231"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="504"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9521452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="761" mass="85184" checksum="E8CBE17104A531F9" modified="2023-02-22" version="1">MFYSVFVLGKKGPLARVWLAAHWDKKITKAQILETNIVESVDSILQPKIKLSLRTSSHLLLGIVRIYSRKALYLLQDCQDAAFKIKSAFRPGVVDLPDGKTEAAISAITLPEMFDFINDFDLMAEPQLHMEAPPTTTANIRNITLVEDISSLHVDDPLMMNDVRDWSEIGSIGGGSINIKDSADHTLNDSGISLKNNNIDLFDRPALDDGFGGQLGVGIVDDVDADDVFNMPMPDNMNKDGLNIENGLGNEKDNNLENNAVGGGGQSQHDEPMERPHSVMSDTSDQSFGAPASFGGPSSPDSTLGDIDPFNSIAADNTLVGENQLNNDDIAADANGQNQNDQADANQLSQNTMVLEPIDPQIGVLDKKRKRRKKIGMVIDEVKTLSGEEMKAQLSDTSDIVTNLDLAPPNKMLMNWKKTGLSDKLFTLPERSISAKALYHYYSRNLITNRYDEMKQEDDLLDERNNIYPYQQNDDEFVRQNHHQTLNGISDPMMEPLQPIDEYEQQQQQLPLDSSPQPPRTPRISMKNMQSPAPQRKRKKMEDKENKDIGGGSAVKRQPAAVATNNNESRSQTPAAVMDSSNLMMMHDNSSIPGFRDHTISGGDLHGASWNPIDNNQHHYNGNKNLDPNFFQQDQQSEENNEEEEEEDDIFDYAAPMSVGPAEEMLPDETVDQYEERIRTKRSNLLLKYMAVQLEDNGHIQFTNLVRNNKRKLVAQKFYALLVLKKQMAIELYQNAEMPYSELIVTKGQKYDEHMVSTTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3W3</accession>
    <name>A0A922I3W3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3W3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="153" mass="18443" checksum="26841B07262E027E" modified="2023-02-22" version="1">MNNPNNTVNSQWRCIITVAMDKKHIAMYHHYQWCTEQRENVVKRSLLQLYSLWIFDQIMPALHNCNNQMHLKMSSRHARRNNDRRLLIQNRRIQRLVEHRQRIRDERISLRQSFCGIRTLTISILIIILIALIINFIFINHSIKLPENGNFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I478</accession>
    <name>A0A922I478_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I478"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9518228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="8268" checksum="9A853086D741C133" modified="2023-02-22" version="1">MIQLSMRELLKQRNSLLQYGQRKNRKKIIDISRNLFAVNVYMIEIMISTMQMTIVTITMELIVKSCMEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5A0</accession>
    <name>A0A922I5A0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_005407</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5A0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050906">
        <property type="term" value="P:detection of stimulus involved in sensory perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="666"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="894"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="10">
        <location>
            <begin position="124"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9521777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="938" mass="111357" checksum="2CD72706CCC3E892" modified="2023-02-22" version="1">MRLNLQGKMIKIGFFNDHPPYTSANPIRDSTSPVIGLEPDIIDTMAEYFNFSVHYIHCHNRSIMNQMLMDKVIDFEIGGLMMTYHQHLRMNFFFTHWMDYITFGTRWSMKNSTSFTLLLKPFSYQVWFLFIVVFIVFIILNKFKIRIIIPIRIVQHRNRFNSQQYRSSIELNLLWINLSLLFRQPYHWLRYLDTSIKICVIFWTFSALILTTFYSGFISSILAIPIHDGITTVHQFAEQCESQNIIPLIRNNTSWANVFSHSKIDVFQTIWRNSRLINDTEKELRIIASQSMMNGDDRKFAMITARETLRYFRFLFGDGSIYTPPDGDDSTFYPILVSIPVRLSFEYDHQPFNDLIIHLQAAGLLERWRNRQLIRVQYLDESIDSFIDIYNDYDNNGDDGDKIQSNRNPYHMTNFLSSSSLSSIELNMICYFYLWCIIIAIIIFFTEILTKYSLFSFGFLNSINNIIIDKMRLNLQRQIIKIGFFDDPPYTSKRGSISPIIGLEPDIIDTMAEYFNFSVQYIRCDNISEMFRMLHYKETDFNIGGIMMTYDRHLRMNFFFSHWMDYVTFGMRWPERNHNGFNLLLKPFSYQVWFLLITVFIVFIILNKFKIRILIPIRIVHHQNGLNSQQYRSSIDLNLLWINLSLLFRQPYYWLRYLDTSIKICVIFWTFSALILTIFYGGCISSILAIPIHNGITTVHQFAEQCHSQNIIPLILNNTSFVRVFNYSKLDVFQTIWRNSRLIEDMEQELRIIASQSMMNGDDRKFAMITARETLQYFRFLLGDGSIYIPPDGDDSFYPILVSIPVRLSFEYDHQPFNDLIIHLQAAGLLQRWMNQELSRVRDPSESIDSFIDIYNDYDYNGDDDNKIQSNRNPHHMKNLLLSSSSLSFIELNMIFYFYLWCMFINAIIFFMEIFIYKRLLLCKKIIHTFKISFTNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5C3</accession>
    <name>A0A922I5C3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5C3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="115" mass="12571" checksum="D441A77A89BF8681" modified="2023-02-22" version="1">MSPRYNKSQVSTSELSMTPPIATQVSRSVCDNGQHIVRIENQVFHCSNKNTDNDPSAGSPTETLLRLLLPLDVQVWSSFRPNMATTRMATLACPKTSLKHPIGSSDGRCVQRAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5V2</accession>
    <name>A0A922I5V2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5V2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="79" mass="9430" checksum="56520807278F5461" modified="2023-02-22" version="1">MNEKIDEYRKKSIFFRPTFLYKFHFVIVYVAVHIQLKTHQVLKHQNLKHLGSTVPLLLLLMTLNEIKESYVAKQITESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6Y6</accession>
    <name>A0A922I6Y6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6Y6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="104" mass="13025" checksum="2747C4F496D28E00" modified="2023-02-22" version="1">MECDRLFKQIIHNYGHQLRYECRTIRTKLKYIFTNIINLRQLIQLIHRDYRRSKCIANKNPNQCRRYLQLANQLFYYRPSSYRKCLKYYHKIGLLENQFKYNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I728</accession>
    <name>A0A922I728_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I728"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="79" mass="9114" checksum="AB00564422BD3CF8" modified="2023-02-22" version="1" fragment="single">ILEIATSNLTVRNRENDKSKLTRPVQDSKFTIDKMAIQNRENIKSNLTRPVQNRENNKSKLTQSVLNSKFKIEKTSNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7A1</accession>
    <name>A0A922I7A1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase Q</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Plasma glutamate carboxypeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">DERF_000407</name>
        <name evidence="24" type="ORF">HUG17_8216</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Derf</strain>
            <tissue evidence="25">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">JKM2019</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Derf</strain>
            <tissue evidence="25">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="20">Homodimer. The monomeric form is inactive while the homodimer is active.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7A1"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000036">
        <property type="entry name" value="Carboxypeptidase Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000009">
        <property type="entry name" value="Carboxypeptidase Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053:SF3">
        <property type="entry name" value="CARBOXYPEPTIDASE Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PROTEASE FAMILY M28 PLASMA GLUTAMATE CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 24" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 22" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="17" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276942" description="Carboxypeptidase Q" evidence="22">
        <location>
            <begin position="19"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="23">
        <location>
            <begin position="279"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00025833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAH7640747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAH9526309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="481" mass="54429" checksum="D181593AEEFDB890" modified="2023-02-22" version="1">MRFYSICTIWATIVVATATDSNSDTTFIFNGDGCEQNHLFQTRYRPQIQQLASDVQRIIDHVMSVNESGRTYRQLAEFVDRFGSRLTGTKNLEDSIDYMIDLLRQEGHDNVHGESVQVPRWTRGNEWARMIKPREKKLNILGLGYSEGTNGQTIEAPIVVVRNFTELEQKSRLIPGKIVVYNFHYESYGKQAIYRHSGASRAAEFGAVAAMIRSLTPFSIDSPHTGMQTYDVNVTRIPAISITAEDADLFQRFSDRNEEVIVQIYSENRNEKEQGISRNTVSDIRGEQYPDEIVLVSGHIDSWDVGQGALDDGAGSFISWRALSVIKQLGLRPKRTMRSILWTGEEFGLIGVFDYVKKHQNELKNYVLAMESDIGTFTPKGITFSGRNSTSQCTLWEILQLMHPINATTLTISTEGSDVQAFYENGVPISSLDTANDKYFYFHHTQGDTMTVEQSDDLDKCQALWTSVSYALAMLDDRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8P6</accession>
    <name>A0A922I8P6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhophilin, Rho GTPase binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PDCD6IP</name>
        <name evidence="4" type="ORF">DERF_000450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8P6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="3"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="713"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="783"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="436"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="555"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="612"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="783"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9526352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="809" mass="91657" checksum="274F0ED41C623394" modified="2023-02-22" version="1">MEFLVAIPLKKTYEVDLVKYLKVSINAQYGNVDEKSKDNLEVMNRMRNNATSRNIESSQETSLEIIEKYYDQLVLLNNKLPQANVPFKWKDAFEKGGIFSSSSMTVSNLSFEKVCIMFNIGALMSTLGAYYCKEGAFNDNSLKQAIKHFQGAAGIFQALKHTTSSSSDGNELTFDLQTEVLNMLQHMMLAQAQEAFFFKAYNDGMKENSVARIAAQCVEFYGEVEKQIQSINFKDKSFLPEWVDIIIQKHNAYKGVAEYYQAMVAKDKKEFGEQITRLTKALEFFKSAETRVAISMAEKFKDIVNKATLALEEVKRDNDFIYHARIPDYKSLPTISKALLAKSTELPNLFFPNESDLFVNLLPLVMHQSISRLENRKQELVNGEIGQLRDMTQTLSGILASLNLPAAIEDTQGVEVPKSIEEKATAIRQKGGIEEINRLINELPDLLKRNREILDEIERSLNAEEESDSKLRGQFKEKWTRTPSNKLNQTWRSHISKYRTIIEKAVEADKKLKVNYDNNIEKIKLLSSPATALASAIPSNQASGSSVDDSAVQSLRQLMIQVDALKRERESLENELKNIEFEELRKQFLNYLNVNTGVDETSVAAEVIGSAYNELQKKVRQSKEKQERLITEIQEANQKFVVQRGSSGSKRDQFLKDCAAAYEAYTQLLSNLKEGNKFYNDLTQLLVNLQVKVNDFCFARKAEREELCKDLQNDIVSKPNDPVPKIPDYQKPDSGSSSSVPPAAPYQQFNPYQAPGYNYYPPPPLPQGFNPFVMPQPPPVAYYPAPNYQYPPQGGHPQPGSYPYQPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9S7</accession>
    <name>A0A922I9S7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat protein 39B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TTC39B_3</name>
        <name evidence="3" type="ORF">DERF_005592</name>
        <name evidence="2" type="ORF">HUG17_3436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9S7"/>
    <dbReference type="OrthoDB" id="6490153at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7639403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9521988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="660" mass="77360" checksum="BE02F33314E2CE41" modified="2023-02-22" version="1">MEQQQQQQQKENEPPIRHLMPLDESIMKSKKCVELLVDNRYMDAVELSSQLSDQSLYHSHCHSMLLFFKVYMSLELPEVKKAEEASQKTIKFCEEIRSLTLRDNFFVKMFFDHDYNQFNDEELHAELIRAEQTVFATLMEFCVDQSIFVLMKVSYRLRSVYMMFKSFAKILDTKEWSSETSASTFTTGVKLGLGIYNLMFSMVPERLMSILSMVGFKGSKYEGLALLREASDANDIRSFVAQMLVSFYECYLDQMWNVRSTSTVNTINYIQHGLKTNSLSIWYSLFKGKISLIENNLEQAITDFEACVRLKNCIDIKQLTTLYHWELMWCYALKGDWKKAIQCCHDLRNICVWSQSTLCYLEASFRIMYLETKLLDDQPPSKPLQRQRNNNGKGKRKQKQVQQQQQQHSSTNDETIQQQRDKIHELLTQVPEKVKRYAGRRLPMEKFSCEKFIKYQQEGRLTCPTYELFITWNHMIFIYGQEQYLLPIINHVDKYLKKFSSDLSDESYFLLMLIKGACFRQLDRLDEAKTCLLEVVKNKKIIKHDRHLYSFACLELGIVLMGQELFDDCQQKLLDARQWIKKEDPMELFVQFRVGKALRMMRRLRDNESSITTTLTNGNDNIPIANGNGDHHHHCNNVTDDINNGHSQIQAEIAVNGNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA58</accession>
    <name>A0A922IA58_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-1 angiotensin II receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_006339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA58"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038166">
        <property type="term" value="P:angiotensin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009436">
        <property type="entry name" value="AGTRAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16521">
        <property type="entry name" value="TYPE-1 ANGIOTENSIN II RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16521:SF3">
        <property type="entry name" value="TYPE-1 ANGIOTENSIN II RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06396">
        <property type="entry name" value="AGTRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00805">
        <property type="entry name" value="AGTRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9522779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25912" checksum="399A8FE5FAD23C8E" modified="2023-02-22" version="1">MDTFDNQVQSFSRSLNRLFLPIIMDPFNSFQRSPIKGTFFLHFILFTCSMLTVNWLPEICFLYNLLFFLTLLWALESKENPEPIQFAAIINLLAILFDIIAMSTNFNHNHYREGFGFSIFLLICNILVRPFTTFVLLRIYSDRDIRQTLYGGGTTTTSGSGIHNPNHDQFNVFGNRTGYQDLDSQPQQSNGPSSTATTTAASAIVNMPYQSVPEPISQQQLIDTTPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB68</accession>
    <name>A0A922IB68_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB68"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="220" mass="25057" checksum="A94178A79803487E" modified="2023-02-22" version="1">MSDVMADNLIIRKNLRIKITKASRRQIALSLDELLNLQKDYDNISAVCLESNPEDFDEQKAKDDLYKQQIEALISCERSVNQLEAITIDDDELIPDLSSIPRLIPSSSHITNNNNFSSSIHHQPSTSSNLLMNVYPATVRASDLLTFDGNVINWLPFKMSFEDEVINNPNLLESKKRKCPLYGGRQLHPLLGRTERLSVLFRWLSHACLFTIRNAVPSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBG2</accession>
    <name>A0A922IBG2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSXT protein (N-terminal region)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ss18</name>
        <name evidence="4" type="ORF">DERF_001942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBG2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007726">
        <property type="entry name" value="SS18_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05030">
        <property type="entry name" value="SSXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SS18 N-terminal" evidence="3">
        <location>
            <begin position="105"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9527960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="643" mass="68310" checksum="50F321646963F689" modified="2023-02-22" version="1">MASTPSAAASAAVPPPTSSSTTSNIGPLPPPTPQGQHHPYSSSMPPPPPHHHHHHHQQQQQQQQQQQPPQGLPGGKSGGHHHHGGGHHHGHHGHRQHPMPQGPPPPISSAQVQKILDENNHLINCIIEYQNRGRVQDFYPLQQALHRNLVYLTSAAETNPNLSQILPPPMFPPPPTTNGPPGPPNHNSTTPGAGYPPNITATAAQVPPHPPPPTNHHPPISTSTTSHSQRTTPPNILENNNNNNTINTDHHNNVNNNNKSTPETGGENAGYPPRSATPSSSRREQLQSQESIPPRPPSVSALPTSQSSNVSNSNPSRPSYGGGKSQPSGQQQHPMYPPASHSSTWMPPTSSQQQPNSPYPHTNQYGQYGPPAVGPSYPPQQQQQQPPPPPPPQQQQQQQQQQQQQQPTAPQQYPGHQNYANYGSNYGPPPPHQNHHAPHHYPNQYGQYPNYPPQSGQWYGSGQAGGPQSAGQQTAGQPTPPNQQYPPPQGGYMPNYYQGYGQPPPPPHQSYGPPLPNMYGGQPPYASTQASNGSGGGGGGSQQAPTAVSQAGSGQPNRYPIPPQQQGYPPAGQYPQPPRGAPPSMHPGYGPPPSSGGYPHNDQSQQSNQQQQYPPSTAAAGPPVSGAPGSVGGYSMPPPPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBW0</accession>
    <name>A0A922IBW0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBW0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036770110" evidence="1">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="105" mass="11487" checksum="816FE84F73957633" modified="2023-02-22" version="1">MNSNKFRFILATIFIISLMANSLVEARSGGDVIILGGFGHGHGHGHDFGHFGHILTLGSLFGAFGDGNVILGRRLNDLFIAIANDSYSKYETWEKNAIDFTDTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC48</accession>
    <name>A0A922IC48_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil-helix-coiled-coil-helix domain-containing protein 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Mitochondrial coiled-coil-helix-coiled-coil-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CHCHD2</name>
        <name evidence="3" type="ORF">DERF_001593</name>
        <name evidence="2" type="ORF">HUG17_4690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC48"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="162" mass="16856" checksum="060D286115BD9E6E" modified="2023-02-22" version="1">MARRGRSSLSSSPTRSSFGPARPSQPRMAASRPMSPPAPSQSLPMRQQSAAVAPAQAPSQGPGLLGQMAATAGGVAIGSAVGHTIGHAITGSGGGQSAETQAPAQVPAQSQYGSEQQQQQQSPCQFELKQFLDCTQNYDLTLCEGFNEALKQCRLQYPSARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICL5</accession>
    <name>A0A922ICL5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exportin-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">XPO6</name>
        <name evidence="10" type="ORF">DERF_002296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040016">
        <property type="entry name" value="XPO6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21452">
        <property type="entry name" value="EXPORTIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21452:SF4">
        <property type="entry name" value="EXPORTIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="9">
        <location>
            <begin position="152"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9528343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1344" mass="156688" checksum="154C2A1CC546F46D" modified="2023-02-22" version="1">MAEINNKSSLLINGQQQQQQSQLLSQHQISDNFILKDSSCQWNNIQTFQNIDTESLLRLESLINEFFLPITGNERKRQIEQSLAEFSNTSNSWQISFIYFERTSNEYTKMYCLTVIESFINQRWHTLSNDIRQSFRTSLWKHLFENHANITPAIRNKFCKILVTIARYDWPYQYPDFMSNILELLTPDPGQNILHSATLILLGLNLLGTAVEELSSNKSYHNHFAGTIELVRILQSQLPNMLQALTLLLESIISKHVNYYSATPPPSPTSIHNQNSNSSSSSSRSNAGSPPNILSHIIKSNDTLGNVFQMSLKKGLLHSIPEMDQEFVHLTSQIFVCLSQIIDFMPVSYFQSINSTLLSALYVLATFGSINSSYNSSKLGLISMNCINELISKVSTFDSEANEFIYNVFHNTFLILQLIVSSSLKSPNDGETRFDEIDEDYLKKFIDFLKLFIGNHLGRFEKFISFPTKDFLQLLFEFTTKMCHSYECYLMLLDTWSVYFDYLENYINQIAASKQHKDKRNVRDEKFESIKEPILSFLLFILRSIQYSCNQDYLKHLDDQTPEDDCRTELENYIYQSIEIVAKIADIYPEETINYIDNYYNEKLQNLYYGLEFLVNNNNNNKPTPSSMMINGDGKSYHCSSPTNDHHNHVPTEQLKLRLEDFIITLQVISRFANYFIDIQFEKYFLRIKMKFDKLCEILHFIEMHKFDNDMYGQTTATNPFLSEFLMLKAQIIATFKAYIVWYQQVCCASDKHSIQIAQAIDHITIIINTCCSIICDNNNCTHLSTIDHHHSITANVDCQSPRISKCLDSKKKMFHSAALTLNTFSANVRPSFVFNLQSVQRLFDQNFQSNLLKLNVTDKGKYESILPSLVDKILISQSISNFLILPWFQLSNEQQNWERRSICLNMFIGNFLHLFNDLDLSDSNRIIATAMQDENIEATKKCPNVYCRSLYILKQVIKSHSDSPLKSKQMLLISLNSSLEAFIQLLTHNQLLNSTIVGCQITEHILSLFIVVFKVLFARIHMDFVERTIQSLLQIINRHNFMVPISRDTSLSNSNNNNSEAWPGLRVIIKFLKLLILVIGQQSLNSFIRTILPDIIDFAVIRIQTTMINVKSPMTIYFKNSTGFHYDIYHKMLKVYYGFLYELLLNNCRYFFPQRLNSIQQQCVVPTTSSSPIKTQNGHHHNHVIDSQQQRHFDSIMEIIGESFLQPENIHLFRQNVDALESMNQKLKLYERLNFREKFRERYLFLFMQTLLDHSLDLLQESLFTIIYHLAQVDFPQFYESFMPKYISNLSLLNDQQRLELMTDFKMEHHHHHHQQIQIDFPTFSSKLNQLLCNVRFFYKCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICT7</accession>
    <name>A0A922ICT7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICT7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="634" mass="67464" checksum="7EEFBF26CD44899B" modified="2023-02-22" version="1">MGLKLSTKRRRGRSYSFTEKDKPTSEVANDSTVTTNGGGGGKGSKKSKRSVSSAAKFSSTARETYVPKNSDTQPPSSNGNIIAAADTATATETATKIEEPSLTEEVTAAANAAVAAITAQASSDVAKESQPEQQQQPPQPNDSAAAPSQPEIAKETVEPAAQPASTESAKESETKSTEIPEPANAEPVKEPEPQPTTVSEPETAAAAPSEPVKEPESVVEPVKEPEPVVEVSPVAAPVAEPEKEAQPVTETAPAAAVVGDEPAKEPVVVEAAKTPEPVESVKESESIAPPVNQQEPEPVVAAAASVVPENPPTTAEPEVVKNEEQQTPEIVEKVEEKQAEQSAEQQPSEISNVEKSEEKVVTEELASQPTPTPVKTTEEIESQPEQQQQPQPEVVPSSQEAISADNKPIEQQQPEQVATESEKPAEMIGENKENESQQQVNIDNVGEKIVADPIATTKLNEQQQQQQSNDNNENVLKNIPCNGDPVANDVISHQENGHATAESPQPEVPVFYSKNKPKGGATAILFNDFFDFFKMFFNVGLSVPVVSNAYMTMCSCFGYPLQQRCCRHCYQMNLAVVPAPAIVPVPAVMPAIIPTATSISIMSSRVCVPPAPVVAAQRPCSSSYRRSSVCSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDS1</accession>
    <name>A0A922IDS1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDS1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="7435" checksum="5B1AC5B356DF93E8" modified="2023-02-22" version="1">MIITITEAGDKKGGDLFIIGGKSGCGPALLYKSNVMYHIPMYSHGGGYSHGGGYSHGGGGGGGGGGSYYHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEH2</accession>
    <name>A0A922IEH2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001827</name>
        <name evidence="2" type="ORF">HUG17_6834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEH2"/>
    <dbReference type="OrthoDB" id="6510531at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7636628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="337" mass="38745" checksum="FA70358CEC8E35D6" modified="2023-02-22" version="1">MESIEDCFVKFFLRQAQEIEPDTIQTLIDHDYRTKLSLTAMDLERDLPLIKEISLAQRSLLRRYLAALQESQPFQVTLTKDPPVGTVCYDYQMGIPIKKRKYDVYIADQSFSYSQDNDRDNPENMNRYGTNLSETPSKKVFDSIVQRINKRKSQIGSHASPEMQTNTEQDQQIGTSASTLRVHSPDMIESSTRMAHDFDNMRPSINNHRNAQEQKLSQLTAMEASTVQDSEMIEEQNVSIRSKRGRKSLVSRTPSQLRYEKIRQSIAAINNNSDASVSPEAVGKTRRSKYTAQSKSDSENDEKKQTVMTPAEREILARIEAKKQQVKVNTKSRRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEJ3</accession>
    <name>A0A922IEJ3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AP1B1</name>
        <name evidence="10" type="ORF">DERF_003894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEJ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000002">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1150:FF:000001">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000003">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="8">
        <location>
            <begin position="702"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="9">
        <location>
            <begin position="821"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9530056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="932" mass="103339" checksum="4F73F3878DE41547" modified="2023-02-22" version="1">MTDAKYFANTKKGEIFELKSELNSDKKEKRREAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDLAIMAVNTFVRDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLRDEDPYVRKTAAVCVAKLHDINAQMVEEQGFLDLLKDLLSDSNPMVVANAVAALSEINEASSSGKSLVELNMQTINKLLTALNECNEWGQVFILDALSNYTPADDREAQSICERVTPRLAHANAAVVLSAVKVLMKFLEMIAQDSDFVGTLTKKLAPPLVTLLSSEPEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANINQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVATLLELIQTKVNYVVQEAIVVIKDIFRKYPNKYESIISTLCENLDTLDEPEARASMIWIIGEYAERIDNADELLETFLEGFHDENTQVQLQLLTAIVKLFLKRPTETQELVQQVLSLATQDSDNPDLRDRGFIYWRLLSTDPAAAKEVVLAEKPLISEETDLLEPTLLDELICHIGSLASVYHKPPSSFVEGRSGYQRKTLMSRNGSGEDNNNAADQAQPTVIPAADSLIGDLLSLDINATGSTNVYPSASTGGSNVDFLGNGLDTLLGGGGGSSDQPSTAAATASTAGLSTTGLLGDIFGLATSETFYSPPKQVWLPAVRGKGLEIEGTFSRRNGQIYMDMTFHNKAMQAMGGFAIQFNKNSFGLAPAQPLQVPTPLQPNTNAEISLQLNTLGQVQKMDPLTSLQVAVKNHVDVFYFSCIVPVNVFCSEDGAMDKRVFLSTWKDIPSQNEVQFNIENVTLTVEQISQKLQSNNIFTIARRNVEGQDMLYQSMKFTNNIWVLAELKIQPGNSQFVLSLKARVTDVATPVHQIYDAILHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF19</accession>
    <name>A0A922IF19_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="25">DOMON domain-containing protein frrs1L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">FRRS1_2</name>
        <name evidence="25" type="ORF">DERF_002808</name>
        <name evidence="24" type="ORF">HUG17_4916</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Derf</strain>
            <tissue evidence="25">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">JKM2019</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Derf</strain>
            <tissue evidence="25">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FRRS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the insect defense protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF19"/>
    <dbReference type="OrthoDB" id="6488868at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF9">
        <property type="entry name" value="CELL WALL INTEGRITY AND STRESS RESPONSE COMPONENT 4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="8" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 20" id="KW-0732">Signal</keyword>
    <keyword evidence="10 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324722" evidence="20">
        <location>
            <begin position="23"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="23">
        <location>
            <begin position="9"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="21">
        <location>
            <begin position="289"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="22">
        <location>
            <begin position="425"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAH7641871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAH9528900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="681" mass="77077" checksum="78E8A27982B10C11" modified="2023-02-22" version="1">MFISYLSMLIYMMMTTVTIIDAYSNGAPNGEACRTLYPGHGVDKQYGRSSYRINASHRFNDSKIVVTLYSPSDTFLGFIMQARLHSDREMLVNGQFSTDEHTQALDCLGGYQNTLTHTNSFPKYKIESVWTAPKNFISDIVFRVTVVQSKNVFWTAIDSDMIELSPNPLGVQYNPNSFNSFNTPNDSPQVPSGFVMNKDGGHHHHHGRSPYHVALSSSAITPPSPFLTVSHQPLVQNSPKHDPSHSTRDLIYYLDYNVCSRKLCFGLPHGCLRRRNCIMLLTAGFVPYTDSTVEFEIIADHKTAMSSKRAVAFGSTSPIISTSAYYSMALSHDKIMGNDSVTDCILSNGRPQIMNSINVGKSNEELSESEFHGVTLMNATYHNGILFCKWRKRRRFTLRGTRYNLRDDKYHIMLAFGRLSSFSNFRRKEPHFDKIVSDSMVDFRMTGSISAYSKTFLIKFHAFFMIVAWVGFASIGIITARYLKPLWLSHSLFGVRIWFAIHRSSMMASLIFVCIGAISIFLYVDGFVFGYHQILGLIAIICAIGNPIGAVFRPECESSKRWIFNWIHWLIGNIGFVCAIGALFMAFQLNAIHLSTPYLWSIAFYLFFNLTVHSLLQLYFCNCHHTKESSDISNGSLPSASNTNQRIDSLADTSFLRYFFILYVSVILIFVITIISFVLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFA1</accession>
    <name>A0A922IFA1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">XKR6_1</name>
        <name evidence="9" type="ORF">DERF_003316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFA1"/>
    <dbReference type="OrthoDB" id="6420233at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF28">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9529431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="446" mass="52357" checksum="3E094459F2EAF440" modified="2023-02-22" version="1">MEIQDVPDSERPLQPNRTSTRRKNMGFWSRTLFQRIFLQSLCRLIIYLNKIYQDFGAVNTYHSEHALYFEIISLLCLILPSMIFAIYQSFAEFIKNENFNAKAIITKFVNGLLLIPWQMKRYLDGLYFSSQNLCSFRQAKDDEKENFFFVNRNAETLEFFEDFYAGFIQVVMQIYILSVETNNKYSFIIGEVIGSALSIFSMLIAIRRRDDGILTGFLSLVGWTSMFASRILVFALAAIIIKQWIVVLCLVHVIGFTIWVYKIAMEALEEMDTQADRSKKRGFSTAVLIFFFFGLPSLVMWPYMFYLKEKQRPMRFLFIVFIENTILVSLWFGLHSTKANTDIYWLMAVIVTTVVATLFLSLYFCCKPSKVDQVVLYDMRYSDTESFGIYFEFCDIVFNLKVEKEVKELLDIIREKPELTHPRYRQQQQQQQVAQPTAPEIDRQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG30</accession>
    <name>A0A922IG30_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG30"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9530327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="240" mass="27788" checksum="47FDB83F1FF8921C" modified="2023-02-22" version="1">MSSSPLTDDLRFFRFFHIALHFLFILIIIRSFFDSILHYQLLDESIRQTLLHHDGDSITVCENYSLIIEDFIIKKNDSARSIIFFLVLTMFIFVSAMLIIGQNWTIITLYTIFQLMLLTLNLFIPFLLPFTSVTIVVASTCLNFTCIIFKIRLNLGRSSRQIDDNDDKSEIIPTDRRLEISDPIPLDGRSIVQFQQQHQHISPFAIQHEQIPFLRSNHHHRHIHGGGVGGNADEEGRTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGG1</accession>
    <name>A0A922IGG1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein RACK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GNB2L1</name>
        <name evidence="8" type="ORF">DERF_003165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGG1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001252">
        <property type="entry name" value="Receptor of activated protein C kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9529274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="310" mass="34486" checksum="E01F6ED642F96D98" modified="2023-02-22" version="1">MATVSQPPSEELVLKGTLIGHSNWVTQIATTKQYPDTILSSSRDKTLIVWKLNHDEANYVLSQDGHYALSGSWDKTLRLWDLNLCKTTRRFEGHTNDVLSVAFSPDNRQIVSGSRDKSIKLWNTIAQCKYSIEEANGHSDWVSCVRFSPSSTNPIIVSAGWDRMVKVWNLANCRLKTDHIGHVGYLNTVTVSPDGSLCASGGKDFKAMLWDLTEGKHLYTLDHNDIINALCFSPNKYWLCVATGPTIKIWDLEGKNLVDELKPEILASKGKAPQCISLAWSHDGSTLFAGYTDNQIRVWQVVPASMSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KRB3</accession>
    <name>A0A922KRB3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_016687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000010">
        <property type="protein sequence ID" value="KAH9490487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KRB3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9490487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="208" mass="23888" checksum="EDA685411B8E8577" modified="2023-02-22" version="1">MSTDLMNSPSIRRSNSYRIALRKSGVPKELLENNDYQSNADNNDYQSNADNNESQQQTQSTTSASISKERLFKKRKQQGINPIFSSSKISSRDSNEKEMILMAINGDNDGGNAYYKQKSHDDDENDEDSNDETLTLKPLSLDTEFETQIDNVQRESIVQNGQHSKIKNDQIIEKNINDEQNIYSKCKHLFCLFCCCNYCCCLLRDYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KSK1</accession>
    <name>A0A922KSK1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KSK1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="138" mass="15367" checksum="AAA3165A6296A1F9" modified="2023-02-22" version="1">MATISHYIVAIVVIMVVYDDHFHHRNSSMAASILLLPPTASLSSSTLIRNNEADTALLLDLPTTNDDRTKLVTHNNDNHSILLFPNSPSSSSSLTQSNVFALYNEILLTKFIFSLPSKMSITTIQLFSYCTKTTRYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVJ8</accession>
    <name>A0A922KVJ8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_016684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000010">
        <property type="protein sequence ID" value="KAH9490484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVJ8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9490484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="61256" checksum="975A42CFFEF94747" modified="2023-02-22" version="1">MARNSFSRISDYLCEEILMYLPPEDKIRLEFVSQQFKRTIFRRQYRFVIAPSCNEWSKVKNVLLKRFVGDFNVIHKIDIQLFDKILSKFRYIDDFAIHYNLDTSNMDEIFECLMRHCIRIRRMDANFFNVSEKTLDAFGKRFGHSLRVVKSSIVSNTKIPNSFALLRHCSNLVSLNGSEFLNEKLWNNVFNTMLENDYTNEEDIGEDDEAEAVMQDCNEFCLEKENFNEVVLPNLKSCYLKVTNEEGVNHLEKFSDVFMNRLEKIKVELVDYIARHHYMVNFIFPLGICKFRNLRECILTLKYNGGYDADFLWINNGLNGIAQDCTKIQHLGIDFIGHQDFFINHVLQALTCFKTLPHLSISISMYNKGLNFPVMPSLNQLDLAYPRLYQCTHLKQLVYSFPNIIVLRLHRMYFFNDVLLNSLIGLKKLQTLRVGGLCPPDVSTIGLKTFLNAAQQIRSIGFDTRPKIDTKTFEMIIDFVQKHENIYYDFDFCLEDFDPNEKKEFEQFFNKVQLPKNLSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYU3</accession>
    <name>A0A922KYU3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ceramide synthase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CERS1_3</name>
        <name evidence="10" type="ORF">DERF_012741</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYU3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="100"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="414"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9501932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="669" mass="80856" checksum="71A42BB45E7E8817" modified="2023-02-22" version="1">MLITITMIRLLEQYWHIINGTHYGLAIVYPHYIQEKIFPPFFDDLIQNVQELLIENHFYWQQLLWISFTVLIISNIRHYFCRYIVNFLIENHYLLERDRKRFSGNIWDSVFYLHTVLLARFICIRLQLLNDENDTKFLWLNNEETVGVDSFLIRLLYLIDMANYLHSAHYIIFIDQWDKDSPMMIVHHVIAAFMLTISYIIHMERIGVVMIYLLEICEVCYFIRCLSKLQIHLLQRHLNPLRLLVFSVLIIVWYYNRLYRYPIIILQSSIEFGFNQLINMKQVAIYILLYYLTLIIQLFNIYWAIQLIRVIIRIFRKGLENIEDFPDYWNMINDSHHLLINVYPEIYDHQPSSSLLFFLQSYWQLFVLNNYCLSEIISIILGITIISIARKLLLINIIDKLLQRRLLLRQDYNKFAIYSWEFLFFTMTVIISGKIVLIDNQWLQQPELFWTDLSIDNNHHKQMATMIKFLYIMDISNYIHSAFIIIFKEKTWNRDSPLLIIHHIIACLLLITSYMIRSYRIGVAMIFLMETNEIFYFIRCIIKLQFTIIQKYSNQLRLIGFSLLTCSWFLNRLYLYPLILIKSAIEFGSTIECKQSPWLIIYVFIYYLMIIILCFNIYWSIILINSIIHIYRNGLTRIEDIREYDYNCNDNNNDLDDDDVDDDIKNKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZ72</accession>
    <name>A0A922KZ72_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear transcription factor Y subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CAAT box DNA-binding protein subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Nuclear transcription factor Y subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_013861</name>
        <name evidence="14" type="ORF">HUG17_0816</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZ72"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="13">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7645278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9497923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="295" mass="33379" checksum="B572A2D1439CBFEE" modified="2023-02-22" version="1">MESISKNVSAEAIQMLETFWKREMVSVQNTTCNDFRNQELPLARIKKIMKLDEDVQMISAEAPVLFAKAVEMFIAELSLRAWINTEENKRRTLQRNDISTAISKYDQFDFLIDIVPRETKPVNRKSDTRGSNTITNQDQYNYLVQIPQTPSTIHHHTGTGQPIQILQTTPNQSNQFSLSPQIIQVPIQSSSSSSTNHDATTHIINQNSQVQQLPITLSSQQYQTLIQNQNSNQQQILLPTQYLATNTHGQMVQTLISTSSSQALNNSTNINNNNNKIITQQTNRSHSTIAQSRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0S5</accession>
    <name>A0A922L0S5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Origin recognition complex subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ORC5</name>
        <name evidence="7" type="ORF">DERF_013653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0S5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC1/DEAH AAA+ ATPase" evidence="4">
        <location>
            <begin position="36"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="6">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="5">
        <location>
            <begin position="324"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9497687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="470" mass="55864" checksum="8A68159501694A11" modified="2023-02-22" version="1">MSTNNIVANVETKFLCRHRQIRKLSHFLKLNDIHNIILNGPKSTGKTCITKMLLDQFEYIYLWFDMINLDNSNRFFYDKILQQFKDYLNEKFSNTDNDGDDDDSEFVSKKCLNPIQFIDYMIKLLQIYRQKTSLHDNNKIIIVIDNADILIEENNENLIYLLNNLDQLTGHICPITVIWIFKHHLERLFRLTTDFKMNALQISFEPYEQEELFQLLTQSSLLPKNDTHKLYRTFVNLILKTLTPFENDFPNLNFICHKYFEKYTTPLNDDEIALYNKSGHLYVKFQPYLQEIMDQISGMVINGLNKNVRQFIESMSPSLCYTYVSAYLATYNSTKTDIRFFVRNQRNNRSKKSMNIKDNEIKCPKWFELERSYHIYRAIIDLNEKDYDLRMNLLINDDCEFLRQMANLYDSKILSSKSTQQQWSCSGDSKFQLSQVITDDMILDISSKIDLDINAFLVHRIERSNKQIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L167</accession>
    <name>A0A922L167_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prohormone-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_010953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L167"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053103">
        <property type="entry name" value="IDLSRF-like_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20967">
        <property type="entry name" value="PROHORMONE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20967:SF0">
        <property type="entry name" value="PROHORMONE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22879" checksum="AAF8EF88E559CD0E" modified="2023-02-22" version="1">MNCVLLRASHIPILVFVFFGLARGAYLVDFSNMMQHRNNLANVKRDDPERCHPTQPFRCPGNSLICISIQYLCDGAPDCPDGYDEDTSLCTAAKRPPVEETANFLQSLLTNHGPNYLEKLFGKKARDALAPLGGSHQVAVALSESETLDDFASALHLMKSDKEHLRNILIAVESGDLGLLKSMGIRDSELTDLKLFLDKLVQTGFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L280</accession>
    <name>A0A922L280_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DERF_010118</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L280"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="14" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="480"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="229"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="761"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9511672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="872" mass="99486" checksum="56E1DFC8D5F62A4E" modified="2023-02-22" version="1">MTQLNPKNVQFLNLDKVPYHHWYESIKECLIAMECDQFIDPKFDYKPKSGLTKEQKIGINSSKNLIKSSLNSMDRETVINCETPLEMINKLEYKYRSSHTRNVFDLFRQNHKIKFEGDISKLFSEVKRNSLQLAEKNLKLPDSCIVAKIIDVLPNEYKDICNQVELLNIKDESSITSDVFESMLLRRERELKDNESESTGVTLVTAKNRKKSNLKCNFCGLNNHLEKDCYRKNPSKSKNQKRPFYRQSNQQAKKKHDKNNDDDDNNLDVATTLVLAASLVATNSQSPKFLADTGASYHIVNDKSLLVNHRHAERMIRGLKHSTKINVIGDLKCEFFNGTMWSSGLITDVAYVPDQPFNLISVGQLCRKGAKINTNKDGMVISRFGKPIIVANWSKDYENLFDLQIRVKQNVIASAASSIDSMALWHERCAHFSTKTISKMMNNKLVDGVPSNIGNNISFCVSCKSGKMTGTSHLKSSNHQYLKPGLKLHLDIGGYTTRSIHGNMYYLVAVDEFTNYIKIAFMKNRQETLEKFRKIVNEIKLDTGNDVLSIRTDHGSEFLSKDFKSFINSRGILHELATVKTPQQNGRVERAIRNIVDHSISMLSSSNLPLSLWDESTNCSVYVINRMLNSRNEIPFEKYFGRRVDLSNLRIFGSLGYALIKNDRHKYSSKTKKVFMVGYHSSNTYRVYCPTNRRIEFACDVKFNEQAKCHISTNSSNIDKNLNSINNDDQNLSFSSNESTDLNHHDQTVTNPNIVIVNGGSDIDSINNPTGGSDENVTDTDLDDNDSEHVETTNRRSVGRPLGSSNQNWDNIRDMVPQLPLYPLVQQELNSIARRIIVVEEIPTAIQHWYRLYGNSPRYITFRITSSYVKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2B4</accession>
    <name>A0A922L2B4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DERF_009205</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Derf</strain>
            <tissue evidence="21">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Derf</strain>
            <tissue evidence="21">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 18"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2B4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000003">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAH9510696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="228" mass="26662" checksum="90EF4203D6877469" modified="2023-02-22" version="1">MNEQQKTQKNFKEENIFLFVPNLIGYARIILALASFYTMPNRPITTLVLYFLSAFLDVFDGYAARRFNQSTRFGAMLDQLTDRCGTMCLLFVLGTLYPAYLFWLQLSAVIDIASHWMHLQVSLMCGRTSHKMISLEDNPILYLYYNSRPMLFFMCFFNELFYVSLYMLYFFEGPTVLGFGLFHLATYVSMPIAGLKALISILQLITACYNCQQLDLDERRHYQMRKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2D6</accession>
    <name>A0A922L2D6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_010694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06667">
        <property type="entry name" value="PDZ2_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06791">
        <property type="entry name" value="PDZ3_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06669">
        <property type="entry name" value="PDZ5_MUPP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000070">
        <property type="entry name" value="Multiple PDZ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
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    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF92">
        <property type="entry name" value="PATJ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="303"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="456"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="656"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="852"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1081"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="1450"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1287"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1374"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1587"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1374"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1396"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9505931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1656" mass="183711" checksum="0EE40D6CA104B902" modified="2023-02-22" version="1">MKMMTNTNNNNIVNDIKKLQDSLEKLYNTSSINFNGNVVGQQQSSTHQLLKDDIRILLDVLECPVFESILNVQYSLQQLREQFQQHPSILPVDVDIDTTTLELNLNLPNDDNNNISINQQQPQQQQLNKHHHQQHTHNNDNERGEAVIAVGGIGDHHNNQFDYDNRTIPSKFSLQQYMYDYDNQEQSSIGGGSGGGRDYCEPDYVNISLQDEAFRKGINELAQGRMIQTVELYKPEGKSLGFKVVGLNHPSSSSDSLFGNNGTTNNNSGSNSNGQQQQQQPEQEKQQKGHHFDDMLNNNKKLGIYIQEIHENGIAARSGLLKPLDQILAIDRHLFTNDLSHEDAINILQSAKGVIRLIVARPNTNNNNNNSNDVIDDVKTSSISTTTTTTTLPTTIIAQSTNSKQITTTLSDVKRSPSNASDSSSSNNSSIANNNNNNCNNDNNMVLNTEWIQIDCIELDQENENGLGFGIVGGRSSGVIVKTIIPGGAAAKDNRLQIGDHILQINGVNMRGMSSDQVAQILRQTNGQHIKLIVARPVDPSLDLQVIQNTLTIVPTKSINDPIELEKQIHLLSIQQQQQQQCNQENINCFNQQSNDYNMIDVQQQQQHRHINDNNNNLKFSNNNNNNNNLVANVSDILISSTNDPKFQSDQMETFEVELIKDQQGLGITIAGYVCEKVAEEISGIFIKSIATGSVAERSKMIQINDQIIEVDKRSLYGYNNLQAVDLLRNTGKIVRLKLARYIKGSKYHDQIQQGVMNAEQQQQITAVAAAAATTTTTTVRGGPTVIQINSSNNNNNNNSTSPSMNLITSVPSSSTSLAHRSPNDLREKWSAIVGPDFDIIIASVTKFCHDGGLGISLEGVIDIENGNECRPHHYINSILSNGPVGRNGLLQKNDELLEVNGIRLHGLKHSDVLPLLKDLPIEVQLVCARPKPTTTISANNMTTTINNKNPFVVQMPTTTTTTTQQSNIDIAKFNNTTISTTVGSGDDGGYPLSPSSSFNQVHLQQHLHHHLDPSPMTSTSFIDRLVKAKSDGSLAMMTTPIAGTFTGLDDDVSSNELSKIRSRSLEPLTGLAMWSHEPQVIKLMKGERGLGFSILDYQDPMNPNDTVIVIRSLVPGGVAQQDGRLLPGDRLLFVNDQNLENASLDKAVQALKGAPKGVVIVGVAKPLPLPESALHLAAVAASSSLSTTKNNNNDPITQENYYSTTITEMDDEETLLIVNDDDLDIHHNYNDDHDGNDDEIDNEKQNMMDARLLLTLVPQQQQQQQQHNDEPTTNINANGIMDMMNEKHDDNDHQQQLQNKQDKISTTMTESSSMMMMMNNTTTNTAATTATTTEDDIYSEKFLPSNIVVDHDDDDSNTCMATATTTMILPLSSSSTTTTTFSNDKNDISKNNYSQQQQQQQQHQQQQQRKTLTSSINYMNDNQCKTLNNNFTSSSSSSRLLLPTTWERTIRLTNNKNRTNTNTTTTTTYYLGMVLALADNASNGYIVKSLDPNGVIDQDGRINIGDYIVTLNGKSLRGLSKTDVLAILDDCEQRQQQQQQQRIRRCKIDTKNDDDIDDDDIMYIAKCLATTMKPEIIATTKTTAAYDDDDDDKHLNEKKSGHHNKRINDDDNDEKIDESSASFSEDRNENLKTNKNLLRSSNFNCSSINAKQQWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2T7</accession>
    <name>A0A922L2T7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Endoplasmic reticulum resident protein 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERP29_1</name>
        <name evidence="6" type="ORF">DERF_006651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2T7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1150.12:FF:000001">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016855">
        <property type="entry name" value="ERp29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012883">
        <property type="entry name" value="ERp29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12211">
        <property type="entry name" value="ENDOPLASMIC RETICULUM PROTEIN ERP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12211:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07912">
        <property type="entry name" value="ERp29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037978044" evidence="3">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ERp29 N-terminal" evidence="5">
        <location>
            <begin position="35"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum resident protein 29 C-terminal" evidence="4">
        <location>
            <begin position="159"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9515876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="273" mass="32084" checksum="CD04AE99B389C313" modified="2023-02-22" version="1">MISFNVLLILSFILSAKIVYSQEDELLVAKLSYFNAKKIISNFKAVIVKFDESYSVNPDKDAEYKILAEELRFSMDIFVGHIVVPYQADDMDKNEMTEEQKLAKQYNITGPENMPVIFLYREKNFENPIRFNGKQFDSYTLRDFIRTNVPGLSFQLKSCIPEFDNLAKDFIRDNKSAEKRKKILKNTEKQMNNMRNEDHKNSAKIYVKIMERILERGDIFIESEFERIRNLLNGKLSDQKKVDLKNRLNIVDSFRSLSMTKIGKDEFFITKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L325</accession>
    <name>A0A922L325_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G-protein coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pdfr-1</name>
        <name evidence="10" type="ORF">DERF_006878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L325"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15041">
        <property type="entry name" value="7tmB1_hormone_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF15">
        <property type="entry name" value="DIURETIC HORMONE 44 RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="45"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9516116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="494" mass="56757" checksum="F2E3A35177D73028" modified="2023-02-22" version="1" fragment="single">FAYRICDNNGTWINNWTNYTECLLLIANNESDTDASKYQFIRQLVIFIMFSCSMLSLILLSITFFIFTYFRSLTSCRLRVHRNLVLALILHSLCLLLIASPHLFNPDESLSSYWEIEWLCKSILTLKLYSTLASINWMFIEGFQLHSRVTVSILRKDAPFKLYHFLGWGIPLVLVTAWALQMSLTMDTLCWNGYAHSLYIWIIVGPMILALSVNCIFLVNIIRVLLTKLRLTVTIEIKQIRKAIKATALLFPLLGISHLLFCINPDDNGRLEDAYLIFNAFLQSSQGIFVSILYCFMDTDVQQALKLTYQRTVFKNRSFPTRWSRQTATTTAAKTPTIRDRNLGSFKFVRQPMINNIVRTNSLNEINIGMEIANHANRSLNDKTHDKDETNKHLARQNNGFALNTTKMVINSTAYGHQMDVREILSQQSQSQRSAGKTISPSTTRESQTLCIMYNSNGEMVRFKPKIQYSNPKPYSMPDTGIIAIEIDPKTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L392</accession>
    <name>A0A922L392_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_012217</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L392"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="10">
        <location>
            <begin position="57"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="848"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="506"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="656"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="848"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9501363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="876" mass="102064" checksum="F3759E9B71978C3C" modified="2023-02-22" version="1">MACTFNTTSMMESQQDSTYDSSSENIIQKNLTFNKCDSSNSIVHDETFDESICNEQIIKTFLRIRSDVEIDSRYKIIDNNLSIDKNLKTTDEYRFDKIFYQEYSQYDVFKVCTLPLLKEFIVGKNSLIFTFGVTSSGKTFTMKGNVKNPGIIPYSLVILFQMFAEAMEIKLPTYKPICFSDRKRLTKNDQNYEDEIRKYIVHDSMGKNDGKNFQITENLIYNNHLDLIEQLQKMFKSMSKEKQEVCIWISYFEIYNDTIIDLLNVRYKDEMEPKIMFIKDNKEQYYVNGIRQVFVESATDAYMVYLFGQNNLKKHMAQTALNPSSSRSHSIFKITLIRIDHSTAETFTSNINFCDLAGAERIAKTGNVGNRAKETNKINQSLCLLNQCISSLTGKKDHQNIISFRSSKLTHVLQPYLFSNGGSFSTIINLNPSTKLFDESIYSLNFCDNIKAVPISQMPSYKRRMTMAFSHNLEDVDEDSESEEMEDDDEENESEIINNIKNPCNCDKLKKEKLLLAKEIEECRQEYNELIDELRDQMNEQNENHEDDLKRNDKLWLMRIDCIQDKYHTELDTKIAKIELLENQLFDVQSELVESQQIQSELIKAIKNCEDQFDRKMKKIDIELKQYELIYGQKLEKINGYFKLSVKESAKTRQIIQELRTTNEANESENKSLQKENELLKDKLRTTNEANESENKSLQKENELLKNKLRTTIEANESENKSLQKENELLKNKLSKIVKANESENKSLITIFDKNASLEYKSSTIVKEQESEKKILRQVNENLNNESELLKKSYDAGTFSDKKKKRAAIQQQMSSTTKKLKLTKQDISSPSDLISPDTMLSEFKSEQKCTQSNNAYNTRSKNNAYNTRNKNRRKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3H3</accession>
    <name>A0A922L3H3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3H3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="8050" checksum="4EEBE2D1C444DD03" modified="2023-02-22" version="1">MTRLCLAWIEFFRPFDCFNFLSLLNHQKVLYELNHKQAISAEKKIFYQKKNNLEVEDESKRENNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3R5</accession>
    <name>A0A922L3R5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Exocyst complex component 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EXOC2</name>
        <name evidence="11" type="ORF">DERF_007554</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3R5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000196">
        <property type="entry name" value="Exocyst complex component 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IPT/TIG" evidence="9">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="10">
        <location>
            <begin position="128"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9516836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="849" mass="97997" checksum="999BD42C92C86480" modified="2023-02-22" version="1">MALAPKVTGISPKEGHPRTKLTIRGENLGINQFDLSSVKICDIECLVFTEWITPQKIITKSPNCVETGPVIVTTKSGGTGISMIQFRALEQPIGLTTPSGVWIDENDIFPFDSGVSAAALVSNDGHTKVPMKSQHNDILSDSFNPSMYLVENHNKNRSEPKNTLDSNTFLKANIVSIMDCLNALNNLYLSFKKDRQEFGSDLTVKIDDYIKSANDEAHAIFDNIISRKDDADSMRNALNVLQRYRFLFNLPSNIDKSMQRKDYDVVINDFFRAKNLFSDSSVSVFRKVFHEVEQRIQSFILTLRELFKQCALNMEDNNIDELKKLIKYLSALEENSDPAWDAILLIKQSLFNKINNCRQQYLSSQATNGDADNNLKTMPPDPDNPQKPPQILFVDKTSRLFDRIFNDLFKLGCAYLNGDLYNKNSIDDLKKKREIFEKDLLTQSIKLLCNEYRSVLLPDTNSFNYTSNQALNEIDQDFVLWLPYCLRGAVQCYSNLLKLDFNLIHMQNSGLLKPVQTFIFDLRLYTLTCLFTHKSNDVKNLYKKEVWNIQFDDIYGVRTNLPLAIRNENSVIQIRTADEVDIFTQINVKGLVKQLIQSLINSFLYALERSAANPISNNRNITEDNRSLIVLCNCSYTANYVLPKLYEIFEKYGYPDMSQVIQLTQKKFKDLENKLLETFIERKRDDVIGGIETSMRFFDENWFQEKEMPKDVSYYIKETILNLIYVQSEIYKITPQLVYKTMFEILLATVIEIERLCASYSKQLSDAARVQMLIDINAIEHVFRKTGNNFHLQLQPRIDNCRDLCQISIQDQTIRKLIDDVTNRFCTYMRLQISCFNFNYDNGNINLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4A7</accession>
    <name>A0A922L4A7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">VPS41_1</name>
        <name evidence="2" type="ORF">DERF_008415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4A7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="1">
        <location>
            <begin position="17"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="213" mass="24909" checksum="A2264350E4BA7B80" modified="2023-02-22" version="1">MYVLNIEGVNCSNTFNNLHRSSINQLSIDEKADFIASCSDYRVCIQEFYTTGEPHYTTTFERPVKALAIDPQYGTTSARRFVIGEADRLIFFEKNLLGRYRATCLQQARGVVRIANWFGNFIVWASDLCLKIYDSQSKTIITHLDRDKENDYRIKLDLYQCSFTWRDNRTLLVSWGNSIKICSIRQRNFDSELSLTQAMMVQERIRKYYVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4L0</accession>
    <name>A0A922L4L0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4L0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="105" mass="12204" checksum="34FBBE794D142627" modified="2023-02-22" version="1">MKRSGDWSPLLKSNRQFWRPKTSNLETDDIDNDQDGHPIQQSMATKMAIMNRHQPAIMIDSSSSILSSNDSPNMMIMSPQLQHHNFQHHQQQQRNIIHVTKNDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4W6</accession>
    <name>A0A922L4W6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4W6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6698" checksum="F0CB2ECD35E51106" modified="2023-02-22" version="1">MIDDQVPSDMLYADNLAEHVHFVVVDIHRTATAPIVMPAMAAGPNSPNFQYLIDKSEPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5E8</accession>
    <name>A0A922L5E8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5E8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="489" mass="56660" checksum="55A2BD6BE4BF20D8" modified="2023-02-22" version="1">MQCRVIVQRYIESALNGAALSGVLLFHGLYKDKRVHIGKLKPYHPKKSNHYISTQLIEADILIHLESPCDILDQITTTNDSNIIGLMADYDWYDCQRSYARITSPLIFYCPAPSQPRNHNIGKRNVLSFAYSVVKVASSMVFNFLQPQTSIQVTPVEQLKKVLENQQLATMLKTKFSETGRLLNAMLDPDNKDFTIQLERLFPNITLGPNAPKRYWHLEGCQFEKLFGANYSNLHLRINGLRIDKDYSLLQADPFYIGIAENQTKIEQVCLAEYIGPKFLAYQKRTGCAKKVLFDPIKDQQAKFVFHSKSCSQMITSMKDQWRKIWCRDKSKIKPEEIVQIKTDNDHAYYYCFMQNRTVNGESMPCENQIYQTKIGNNITINRRTIYVKKYQSEQLLDFDPNVTEKLNDRIFHEDKGKIFEDLEFLVEKEHKLLSQIVISHISHVRYYAIGAAIAISNYRGSFDMAEYDCQRSNKGIQNNFPVTYDIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5G5</accession>
    <name>A0A922L5G5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZDHHC1</name>
        <name evidence="10" type="ORF">DERF_008426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5G5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="149"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9517795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="431" mass="50302" checksum="5D793191DAA1152E" modified="2023-02-22" version="1">MTIQIHPKENQNHQSSILLDTTTTTTTKTTNNQQQQQQQQQQQEFVRYNGWNRPFHYFQLIGWTIYIVFGFINFLLFIPNMSSSIDHHNNHNNVLPFLIYNLFIYLMHFFTHIIASTINPIDNNVLAKYSEQKQLKPKKFDRNKHEHVIENQFCYICESNVDMKSKHCSICNKCVSNFDHHCKWLNNCVGGKNYHWFVLSMITALIQALTILVTAILLIISLHVKDFMQTSKLVIVHYEFDNEGTIKIIWSIILYITLVVSTISTLLLLHLCIFHIFLNIIGESTYEFVMRQRSLLKQARQSPSTTMGKNESTSMNRQSQQTKINIGHDEQPLQRGNKSSLFTMFNKFCIFFNQHTHRNNKIKIDITNNNNNNNLEQKLDNNNSNKQVVKKDKIRSTIIMENQIAESQPSTAATTTTTKSNGYNNENQMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L674</accession>
    <name>A0A922L674_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L674"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="104" mass="11964" checksum="6CE37233028F0509" modified="2023-02-22" version="1">MVYNFIPSIIFLHIFSIRRTTERADELISSNFLIFSGRISLTAAKIHFLIYSPSITQMTQISMTRNESNNGNDALKIVGNKPGWLIMTNSMTRMTNGYQHYDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6B2</accession>
    <name>A0A922L6B2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6B2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="53" mass="6449" checksum="F06D013C31E0CB33" modified="2023-02-22" version="1">MTIMSFCNYCMTNLRRHLLINFGNYYWRIDKRFNIVHRCPLFSTLLDNLSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6P5</accession>
    <name>A0A922L6P5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6P5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7783" checksum="EB22E34B353A1122" modified="2023-02-22" version="1" fragment="single">MMTIRKQKENYYHSENGDDDSESGKNILDAICHVYVCSIQSLCTNLISRNQTEKKPMNKRCITENNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L715</accession>
    <name>A0A922L715_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Doublesex and mab-3 transcription factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DMRT1</name>
        <name evidence="8" type="ORF">DERF_010523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L715"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF70">
        <property type="entry name" value="DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9512123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="86" mass="10440" checksum="E748C5C90CFA9ACC" modified="2023-02-22" version="1">MLNHKRFCPWKDCHCAKCDLTNQRKKIMAAQVALRRQQEQEEELGIAVPEIISPEQHQQMIQQAQQHNNNKKQRPHHHHHRHHQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L736</accession>
    <name>A0A922L736_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L736"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7278" checksum="F9FACADF3E9985BF" modified="2023-02-22" version="1">MYIHKNKNVLPLVPEITCYKKRATTTTTINSRGKKVMMVMFHSLKTESESLKLERLRVFSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7F2</accession>
    <name>A0A922L7F2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_006175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7F2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0193">Cuticle</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9522609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="428" mass="46952" checksum="52577B1366FFB06D" modified="2023-02-22" version="1">MSHIYRNIADLGTWLSSSSSSSLSSPVELDSIGMDTRTQTIRLKKSLIKSKVFASIHRSTIICILIWTLLAIEFCSAYYYTEPQQQYGNGAYQFSYQTGTHNEPDLAQSFREESRDEYGNVHGKYGYVDPYGQLRIVKYRAGSDGYYAEGDVGVDQEALRQQRLLYGNDPATRTQQQTWQQAGQGSSSSAAAAVAASAAASASSSAAGGGYYGGTKPDWTTVTDNSISQQYNIKGGNSKSRNIYSERIVAAPIPSPVKTLNYLSNQYNQRQVLTNNQYQLPVVRQYTHTTVHQVPGAIQPTPFIPTAAARYYQTKSYNQQQYSGALKSPAARYTEIQHQQQQPAITPFKSLTSAYKSASSSASSASASSSSSAAYTSDGSSIKGGYRQQQQQQQQRSSRYSIPGTGQAHAQVNFKQYGPAAFQYSYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L809</accession>
    <name>A0A922L809_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L809"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7284" checksum="1237E933FAFD36F2" modified="2023-02-22" version="1">MSIQSTEISTSGLAYFPKQKSGQFIDQYFSTIGSPSLLLTSRYRNKICHFRMNYTITLSNAVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8X2</accession>
    <name>A0A922L8X2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ER membrane protein complex subunit 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EMC10_1</name>
        <name evidence="9" type="ORF">DERF_001720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8X2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037554519" evidence="7">
        <location>
            <begin position="26"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="8">
        <location>
            <begin position="197"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9527711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="609" mass="70458" checksum="7D8632746BF3FD59" modified="2023-02-22" version="1">MPQLHHNHWIKLMLLALIYLGQTSCDHHHHHQANIIINNNNNIDDIQSQNIMNNNQINNLVIIRLYHAFNSEQNYQYRGLLTIQNNVPIIKQDLINDEQLQLLRESAKNGDNYYLKAEAHQTLVFEHEKPYQITKTFIPACALLESSLNDQLWISLDVKFSILKLSSLQAILLTILLAITNGQSMHEDDPDQHRTLVELIESRGFQVEEHSIETNDGYILLAHRIVWPKNSTINSQDLKPVLLQHGLFGASSDFCINSPFLRTKRSLYGDTMAFALMMTKRYDVWLGNSRGNRYSRRHRTRSPANRDFWNFSWDQMATEDLPATIEYIRNATGRKTLAYVGYSQGTAIMFALLSLRPEYADIVQPFIALAPITFVKNIQSPMRYFSPMEPLLRLIGGEFLPSNTLIDNLVDRFCVYPDIRPLCANLIFLFGGFDKKNLNETRIGVYLHFTPSTTSTWDIAHWAQSVNRGRFQRFDYGSSARNQRHYNQSTAPDIPLENIPTSAKIALYQGRNDILSTEPNVEHLKQIFKKSGVTLIRDFIVSDPKWTHLDFGFETKTYLLRVEQQRQEKLRGNKQDNRSFLAKYWIYIVPVMFFMILSSSMNPEAGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9Y4</accession>
    <name>A0A922L9Y4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">1,3-beta-glucanosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GAS2</name>
        <name evidence="8" type="ORF">DERF_000179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GAS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9Y4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21204">
        <property type="entry name" value="CH_GAS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF13">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="181"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="7">
        <location>
            <begin position="575"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="676"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="902"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="532"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="697"/>
            <end position="706"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="904"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9526062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="937" mass="104219" checksum="4A4FE58A1489D1D2" modified="2023-02-22" version="1">MPSSSSSSVTSILPSSTSLPSSCTINGNNHQLDQQQMLTISNDNGMDVEHPINTNDVKMSSNGHSVNNDSPTTTTTTTSLQQSQSILQNDENNDLDMNTLTSRLIERSSYRNSRRRNHNGSSSSSHRQCFATTFKHDENVMTNMVPISRKFVDCSPTTMTELTTDKDYLDYIAKLQMDSLIPLKEDVADWLNRTLNLDESINIDNFMERLENGVLVFKLIRVIEDQICAKHHSDTNMMIDGTPIMINDNGRKLDGSQSVTKKFITMNKMNGHHQLIGTTNSLNRRCSLPIGNENVSGSQPMFNSIGFLSAYHMKCWENAKPHTFFARDNVSNFLEWCRRFGVKDAVLFETEDLVSHVNQRNVVLCILEVARIACTKYSFSPAPGLVELEQEIDREIERELQLQKQAEHTRVTSNDDRKNCQKPEIPDKPATLRTKTAQHHSRNICRQLWPNNENDATIQQDDIDSIDSTRSSFANTTPLTLVNQQSNGSINRECRDDDDEEDITLISAQNDSKDVGFVDADSGCSYSSSNHSDSVLPRSPSSNSVLSSTSSSAASATYFGDHGGCTTETSSTCSSTPTPMTSELDHKVMQIAKTYYGKEARQGVQRLSEGKYKIANRIVFVRLLKARHVMVRVGGGWTTLSHFLARHGGDPNQQILPDELLPLDTKSSQMNCPNGGMNSQSRTANANRHHHSHRIHNNNNNGSTTHTLVISTTTKTTTIHNPNNNVGSARKSSMTSDLLKLTNNNGQQKFISTNGRNVGMMSINSTPVSRRNSVSSTADSPEPSYHSTSATNSVLSTIAPLSSQTKIPILRQTSRSRLPSMIGNETTPSSKQLLRSTSSIISISPSQELSTYLKQQQLRQQTMTNGKIQYTQHSMIPRSTTEFGQMRRYANYLRSSQHITNKESIANSNTSINSQQSQTPTIRPNHRPSTAFGQKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA21</accession>
    <name>A0A922LA21_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Syndecan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">BAG6</name>
        <name evidence="19" type="ORF">DERF_001850</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Cell surface proteoglycan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Membrane</location>
            <topology evidence="2 15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the syndecan proteoglycan family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021925">
        <property type="entry name" value="BAG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027789">
        <property type="entry name" value="Syndecan/Neurexin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030479">
        <property type="entry name" value="Syndecan_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204:SF0">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12057">
        <property type="entry name" value="BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01034">
        <property type="entry name" value="Syndecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00964">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="18">
        <location>
            <begin position="465"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="124"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="532"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="599"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="787"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="923"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1341"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1431"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="207"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="791"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="923"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="969"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1344"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1378"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1397"/>
            <end position="1414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9527858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1470" mass="163567" checksum="423BB07620BF2C57" modified="2023-02-22" version="1">MEMSSNLYESTSMSSTSRLKWKCLHRSKNRPGYSLKPTTIIHKQQSLNSDSSTWTLNGSIDKRHTHHCVRSSSSLSMPITYSKCSSQSILLSDRRLIWQFIAHYDNYPSMIGRSSSIRRNHHHDLNIDNNGESFSSFLPTSTDFRNKNPNEKRGGHNSKQDDPFLDIAEGSGHHRNPNNPNEDEEDDDDDLEIDGSGAADSINDKQSSTTTSTSTSTTTSTTTTTTTTTTTTTMKPIVTSQKSSTSTTVYSSSPMTPKSKVCKTPIDDEDLEGSGDCVDNNDDGIEGSGASNIDQESVVVPSSSSTTESSIVEIPSWTTSTIRPLTTSSSTTTTTTTSQPPPMMTPSIDDVEFPDYVTPPKYIPPRTPSASASFFARPGILAAVIGGTVVGLLCAILMVMFIVYRMRKKDEGSYPIDKTTITKTYRAAHNHHHHHIQIIMDHSTTSGGDEKAPSSPSDAIISDLITVTIKTIDSKNYQFQVENDIKIRAFKEKISSTLNIEPESQRMIFCGRVLADDKTFKDYKIDNGKVIHLVKRAPPPKNDTANNSSNGQNNNQQQNERNRSRFQSFRSDDGSSVFMGSFPTEPSNIINQVMRQLFSQRPGSDSSNESNASDSAVGATSSPSGAGGRNAASSNIRARFNHIRQLLGYVETNFQILQDPSHLPRGNQMNAFGDNQSITLADYARCFSDVISYMDRLKPYLETWIRSLTPEEQNDSSTNNIDRQSQNNFSIIMRIVHHLSHVFHSLTDLSINPNDANSPITLNVLGSPHQQQQASNVDTHFTITASASNVNDDPNASATATTNTNQNQNNSTTETDSENVQQRNSNSSSPSNEFVSPPVPSGDNRLPTNAAPSNNNSMFRSLGSIPGSVFVAQSPILLMEVDATIDGHSTNLGTRAIRNFSISDLNVSFNDLINNASNVAFNAMNQNPNTNPIEPQSQQDSANGINTTAQFSNPPVDSDEAPTGESNPNSSAAATTGTINNNGSSNQNNSNNPMVNPLQLFSARFDPFLNCNSTYTMPEIRSATNFGTMPFSQPLMQMFGQNNIMGDIPNNFRSSALNGEDNDLGILNSMRESLLNLTQLDQGDSPTSDESREFFDFIDYLLRRINQLPSQAGLQFQSGDHQQSPRIQDYIRNLNLLNSNDESMLSNMLSYLFQSLNFQDLYQMINSNFRDFARLRQHLQRAIRVFLMNNHDGTDVRTDIETMIANHPTLLTDIVAKMRPATGVDHVESFRNFVQETLIKFFNKIMQSNNDETFGDDLTDAVKYLMNAYIHFCDACFADPSNARSTLIMRFMTEYADIADQRFRDFLTQIITQRINNWITTDFVKDNQLDAEIQSYIVRRSCRQQEQQPQPNSDGPSNSMDSLEDMEFSDAYSDMPPSTSTHSMHATSSEPQRLHPPTTNRITNNEQESADWQSVVPNEWVPIIKEDIQKQKNIENDHQPPFSDAYLSGMSKKRRLEHDQQQQQSNKQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA80</accession>
    <name>A0A922LA80_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA80"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7271" checksum="BA8B9A8BD7C9C5D1" modified="2023-02-22" version="1">MCWGGDKSAMDFEDDVENTEKKWLMVPRLLSLFFFLSEKVEEVEKRDSAKCNGLRHGGDCGGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAR7</accession>
    <name>A0A922LAR7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAR7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="9752" checksum="615BA99D9BEE0DDE" modified="2023-02-22" version="1">MKLKIATDNGKKWQDYQNESMENRFIHQLKLKRVGPYEHSMDTQALDFDILIFADGLLCLINNNSNIGKKDENFYKANRNCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBN6</accession>
    <name>A0A922LBN6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_005826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBN6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037643031" evidence="2">
        <location>
            <begin position="28"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9522235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="590" mass="66586" checksum="3A83DD0AF2B9BBDE" modified="2023-02-22" version="1">MKHQTIHCLMAMLFITIITIVIDQSNTSPITITKILAGKKKFKTYSLGISFLPTLVKVKPNKLHLTIRQNQYIRPKKFKMDGSLPLKVPTILMAKRNPYAEPPKDVVINADIALGPEKYSKKPSYGYASSSAAAASEPEPIIETIPSSQPQQPLPPLEIPIPFPMENPPPTSIQFDDNIGQPRLPPPIDSNEQKLLLQHAAESNQQVSGYDQNELMLAPPPAPLPPPPVLRPLPSKFPMEIPHLPLPKEYKFQGMSKQSSKDKPLEIRRSSNLPEPYHHHLINRQESESSLLPPPPPPMFFPPPPHLPPPLLMAPIHQPPMFQHAPVSPSTIRRIPWGPRRPDQHMFHDSSPVSSASQPQSSISRQMAIELTDVTSIDDPIGSTNQQQIEKEHRPMKINIGEHYDPNMIYVDEQTIPSQSQIDELTNNPVPMHDEDMDDDSFGSNPVGQPTKGFIPELITGDDLSDTAMAESSIQYVKKYGGKNKYYKKKKYGNDGPDDFRIEFNLSGPHGGPMVPYGYGDDQDQLNKQLNQIQQYIPVGPHAKSIYNYYLRHTFTEPIRTWPYSYARVKKLKKLIPERQRKPMPPLHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCM7</accession>
    <name>A0A922LCM7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_000769</name>
        <name evidence="6" type="ORF">HUG17_8510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7641041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCM7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="16"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7641041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9526705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="300" mass="34774" checksum="1C7C7BCB54CDAE52" modified="2023-02-22" version="1">MIDDDGKKVKKKLIIKTWFNEIATLHHDDLIISTRINQLIHRQRSDYQNILIFQNQIFGRCLALDDAIQCTELDECAYQEMIAFLPMNIHRHPKRVLIIGGGDGGVARECCKHPLVEQVVQCEIDKRVVEASKRYLPFMSKSFSNENKLIMNFQDGYEYVQQHPLEFDVIITDSCDPKGPAQLLFDAKYYQQLFQCLRPGGVICSQAESYWFELKFIQSLFDKVDKIFPSISYATTSVPSYPSGQIGFLLASNEANFNFVEPKHRFNEQDCERFGLKYYSESMHKASFVLPRFVRKALNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HFQ6</accession>
    <name>A0A922HFQ6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="9">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_015938</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="9"/>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF609">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="599"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="713"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1100"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1196"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1294"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1396"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1212"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1224"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1302"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1319"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1332"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1404"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1428"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9491207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1437" mass="166812" checksum="D1AE057DE2928F09" modified="2023-02-22" version="1">MALNEGGKHPHCYWMRKLLLLLSSYNYGGSHRGKIPRSTSSTLLLSLKLYYIRIVSTWILLLLLLSTLIDGHQSIETLSSSLTATTTATTTTAATETETIMMMNINENNNDDDQKMETTTMNNVPNLSIVNENNLLPSETVTTSTSTSTTTTTLMTTNKSNLIVNQSKIIVDSDENNDCFNYEQIVKEYPRDQNCQINIDIDGRRFNKKLPNNNNDDNFTKIISQYEHCHIITGFVSLRHFYFDKNDSLLFNNLVFPNIEYVRDFLLVHNFRSFNEDNDDDDENVNITLGHIFPRLRRIYGYRRIDNIALSISDFWTSDHISFDSLQQVCGTIKVLSSRPYFRHSPTYWHLVDKYRNRRLFTNMTRFQSDYVIPVRSIIDNHNESNFIGIESQLRFDKLISTNKRRIYKILHVSIYEIDPTFYSFVETGIEPLSSSETFFCNTSSRIVILSDLDYSDKQFLFPYHTNSFDQERFPYWKMNDVYYQYRNESHLHPEHFLYNNRIDNIDICRLHNIYYDDNNNNGDNDNDNQSMMITNETYPFQFKHYYVIKLELCIERRHEKCIVHQRYIFNPKFEDFEQILLKFSEKQQQQQQPLDGQWIFSTILIIVIIVIIIMLSIIGLFICCIRYIRPYQLFRLKSFVNMDVVSVNPDYGIVSNHHNDNNNIDQLNHFWSSTTFHYNNNDNNQPLSSSSSSSINNDNIVTCEINRQSLILYQQKMIGKGEFGFVFEGRLLLDHDLNCSYHYLAGKNNNMMEETSTLSSCNCSMIQSSPNNNGNGSNDSIPSIRVAIKQLKDSGFTGNGVTINKEKFIQEAKFMKTFNSNFLVKLLGISTVEEPILVVMEYMEHGDLKRFLRTRYQDYLKCRNNDLLPSFDQLARMAIQIADGMHYLHSKNVIHRDLAARNCMVAADLTVKIGDFGLTRDLYEKDYYRLSEEAPMPLRWMAPESIREMIFTPYSDVWSYGIVLWEIMSFGEQPYRGRSDMEVKQQLLTRNAQLSRPIYYFEPLWEIAQLCCRKRPNRRPNFGEIIEMLYPHLSTNRHQFDNLSYYVSSRMGSYVKYSTFGIMINHCLSFVWNVCLSNKSSSSSSSSLSSRKRKSSMFISSSTSAASTSTSQSTRPLLSNNQDQQQQQQRRDTNSSQQSASTIVDCGCTKLPLTFQKKKSNQLKRLQRQFSTCSSSTTTTTATNNNNMDQMIMMNVVYPSPPPPPPPTAPPSGQSQQPPLSSLITCSSQTSQSSHPPLSNLWNNNHQMSNNPTTFLPITQSSTATIPYGSWIQMNSNNNHSNFFPIIAQQQHHNNNHHHNQQQQQQYSSIESLSNSSNTDVQTEITTLTSGHHHHYHHPHHHHHHPHNQLFHNDYHYQHHHHQYPHQQQYDEQLQMDDDDDCHYEIMSAGVGLDRTVVNTNNSDDDTDTDTDNDDDDDMISKEKNNQESSTTKPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HIS3</accession>
    <name>A0A922HIS3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_014497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HIS3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390:SF79">
        <property type="entry name" value="ASPARAGINE-RICH ZINC FINGER PROTEIN AZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24390">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9493764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="465" mass="54168" checksum="A43640BC479CCEDC" modified="2023-02-22" version="1">MMILRPFLIVPTSSSSLSSYQILNENQQQKNGGLANRTNTNENTNVAQQTSKSHDHSNDGYQYLLTKFIEMEKRIERKFVNCSKQFESSIKMDKANEYDKCDEKFISVIEMGKRFDKFESKFDKFLRQFESLTKNFIHQQRRQSFNSQVEHGTSTQSNVVSIDHDYYNANYNSLNEISSSIKTFDSANQSVSLNQIKSTISDDSIITISDDDDDLMGQYSSIDEIPFSIINNDNSVHSIESHSDVQNSSSSSLSNENSITTQIMDEDKKFPCPKCSYRFNTQHNLDIHMKTHKAANKYICTICGARFTRKFSLDRHLNIHTGDLFKCDICDSFFTQKDYLVLHRRTHNGDFPFKCNQCHYVTIHKSSFIIHRRIHDGVEPSFKCNRCEYATHHKNALVYHRRSHTGERPYKCQKCELAYTNSSALLRHRRANHPDDIINSFQCQYCDSKFTRSFLLIRHLRKHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKA3</accession>
    <name>A0A922HKA3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKA3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="115" mass="13504" checksum="C86E1857A6EEEA9C" modified="2023-02-22" version="1">MDQEMDLSQCLFLMSCILTQCMGMFGIHYVCTQYSKRIHTNGIRRLILVDTVKSFASFGSHWKLCSQIEKFHTKNRYGVSYGKFGVISVTGFVRFLLIYCKLMMMIFKIQMHTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKK2</accession>
    <name>A0A922HKK2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane metallo-endopeptidase-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MMEL1_3</name>
        <name evidence="12" type="ORF">DERF_015855</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKK2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF241">
        <property type="entry name" value="GH26575P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="522"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="690"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="1037"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="646"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9491120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1243" mass="139938" checksum="4CEE1A6085057F2D" modified="2023-02-22" version="1">MAQTQTEQNRKQPPSSSSSSSSTTQNGHQILNISSPPQQQQQSTQNPITVPSFDYQLINVNITSSSPPDSDENNHQQEQQQINHNHYNNNHHHLINHPNSMIDTNDDRSSDCSSSLGEHSIMITTPNKLTIIRANSAKNPTYSSGYRRSNLSSSSSGGGGGGGRTSRKSSTIMFQEPHIIKRPNSTIGIPTSMRDSFLNTTGTKQQQHQQPQQQQQQIRPTKTTIIAPLVNNSHQFPIEQTLTTTMTTTTTTTTTMTITPESDISIAQGFNPVIREKASSLTLPDLQLQFLRKGSSNPFITTTSNASDVKPSLLLSSTSNINNNHNLHKYHHHHHNNDWSTNQLSVYEYPNNNNNSNTNPLLANNIDGIGSCGSGGAGSNSGGGVGGGCGGGRLLNSALKTRGSTISLMTNHRSSYIGEEEHYHLQQHYFATTGRKDTIISIGKNFQIQFKSPSTHCLSWRYRTGLEKFLIFLLFASIIILLAYIYIPYLYGNSNEIQVCTSMECVKTSASLLSAMDLNADPCEDFFQFACGNWVKKHIIPEDRSSLSTFEVMADDLQIILKDLLEQLPNSADNSATLKAKRFYQSCMNIQKINQIGVQPILDALQEVGGWPVLDRNWNEKRLKKTTISMTLQTKSLLLASASGVISSSSSPSSSATSSSSSSSSSSSSSSSLLSTSTKMTTTNDQYMDLTLENLLGKLRGDYNQPIIVEQYVGPDDRNSSLNIIQFDQTSLGLPSREYFLKEQPNKEKDAYLELMIDIAELLGADRDYATEEMTKVLEFETQLANSSMPEADRHDTSAIYNKRTIKQLKQLVPEFDWMVYLKNFMPIDIDSNEEVVIYSLDYYQQMGKLLKRIMSEDRRIIINYAVWRLMKSILPFLDNEFGVKRAKFRKILFGISADRTRWSQCVELVNKKMGMAVGALFIRDNFDPKSKEIAIEMIHNIREAFNELLNFNNWMDNETRQVAKEKADAINERIGYPELLTNPIQLSKEYNFLEIHEDKFLQNILNVFRFEAYKNLMKLGMAVDKDSWTTDPAVVNAFYSPNKNDIVFPAGILQPLFYSHYFPKSLNYGGIGVVIGHEITHGFDDRGRQFDKNGNMKQWWNNRTIKRFRERAQCIIDQYSSYVLEDINANVNGRMTQGENIADNGGLKQAYRAFKKWEKRNGIEPLLPGLNLTHDQLFFLNYAQIWCGSMRPEDALNKIRSSVHSPGPIRVLGPLSNSYDFSNAYSCEIGNRMNPIKKCTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKL1</accession>
    <name>A0A922HKL1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase 2</fullName>
            <ecNumber evidence="7">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TOP2B_22</name>
        <name evidence="10" type="ORF">DERF_012965</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="7"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9496944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKL1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase type IIA subunit B" evidence="9">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DNA topoisomerase type IIA subunit B" evidence="9">
        <location>
            <begin position="117"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9496944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="431" mass="49878" checksum="5CA1E080CD02D516" modified="2023-02-22" version="1">MIFIEAFIATFRILSKTLNGECLSVCGFQSYIDLFIKNKEDKNNEPFKLVQYELINDHWEIGVALSENGFQQISFVNNIATTCGGTHVVAILFSVSFQIKNNKPIIIILKIDKIKFYISENGFQQISFVNNIATTCGGTHVEYITNKIIDKLNETINDKIGKTKVNIKPHKLRNHLSVFVNCLIEKPTFDSQTKEAMTLQSKNFGSECVPSEKFFQSIMKIGIVDSFANWICIKKQFEMDNKLCPKKTIDIKGLPNLQDAKKAGTIYSLECMLIITEGVSTKNLVNAGFIFIFSFFHFQQYLEYRQLEENFSTIVNHYHFCEKNIPNCKEQLDKYTDTSIDIYTNPFWKILQNCIHEKDRLKHKMEQTKEMMKQTRSLLQMDELKCHKRVLRRLGYCLSFQINIMSTHMAAVTFVHSIGDFRPNKFSSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMU5</accession>
    <name>A0A922HMU5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMU5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="230" mass="26754" checksum="232371BBF3D693DC" modified="2023-02-22" version="1">MDALKKKLLKDFNSIVYRIKKNQEKNKILQDYMIFIDNLNRYVNQTKWSQFSVGEERWQALSCYVEKNQSNASSSSEIIDQAKLLETQNCWRFSAKSSVGHGNEPPETRIQRPRRMCHPPKEIQKRIKNEGAFENLSSVKVYVDTIDPNEYEYDRKNVCQILYVPVATIKDENMSPNCAKEKPKIPIITLSSDDDNGDNKESIDQNQNEQKKEEMEKINGQSTIKIISKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMU8</accession>
    <name>A0A922HMU8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMU8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="599" mass="66854" checksum="CE30044054CE3BA4" modified="2023-02-22" version="1">MCQLKKMEIQQRSTMTSSSSLTNVTTDSNANVYNGIVIDNKDPLEVDAQQQNPFLANRMSGGGGGGINPQIAMILRNNPRLQLLAQQNPVMAQQIMRNPQLLRDPIIQRAIQSQLSPGQQQGLLGQIGQLGLNGLNGLGRALNPLGLNPLNPMNNNNNNNNNNRNNINRMNQMNNRNQQNFGLPQQRHPQNFGQVNPNHQDRLNGGYYGGNDNYANQTPAPETENEIDDGSSHGDEDSENHVDPGQQDYGGGGGDDNGAGAGDDSQQNPADDPDIQQLQNFGGPLNDNFPEGLFPPGLLSKEDIAEIRRQQEKQQQEEMERERRRQRQPNHQSTSPDYDNSGSGENENGDGSEHQDAEYPEGAGDGEQQQHNDHDGENSSSNENHHDDDQSHNNNDVNGGHIIDTTPLPPAYKNAYQPIQPQYRNHPHRNHMQPINEYHSVPGQHNHHSKNQFNQQQPPNVEYDPNHGQYHHGHPHHHHNYNHQHPMGYSATTFAPPITTSNPGVHYDETDDFNDSNMLNRGGGSGGGYHNRQPFNGGYYRNQPNIHNNQKPLISRSKTLQQQWPGSQQQYPLSTLNNNDDELRRSSLLQNDDDVNESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN61</accession>
    <name>A0A922HN61_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spliceosome-associated protein CWC27 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CWC27</name>
        <name evidence="9" type="ORF">DERF_016070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this complex as he matures to the spliceosome C complex. Component of the minor spliceosome, which splices U12-type introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN61"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000007">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CWC27 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="591"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="591"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9491343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="731" mass="83526" checksum="B5F586DD0BA5E6C2" modified="2023-02-22" version="1">MSNIYIQEPPTCGKVLLKTTVGDIDIELWSKETPLACRNFIQLCMEGYYDNCIFHRLVKGFIVQTGDPTGTGFGGESIYGRPFKDEFHSRLRFVRRGLVAMANGGEKDDNGSQFFFTLESTPELQNKHTIFGKISGKTLYNMLRLGEGEIDRNERPVYPHKIRSIEILNNPFDDIEPREKRLKVKEKSKEDRARERLKGSKNFALLSFGDEAEEEEEEITKISAVFKNKSKSSHDLLKDDDKLSSIPVVDPNELSNDPNDDHEQRHSNENDSDRQKRLANVKAKLDKGTLRKNDDDNDDDDDDGGGGELDFFTEEKLEKKAKEIEKAKNEFQKLKKQMLKKLRKEEQAAAATTTTATASDNDQSKPIINDAVAEFEAESKKFKEINQKIRKKGNGREQQCLDLLQKFKDRLHSTKKDKDHEEEKIVDNDNNDDGGGPLVNFKTSWLSHRMQCTGDDEIVLARDANIRNEEDCPQSPHSPIDEIKSNDTMTDYHISKYIPSQLTTNDLIVKQIDLESIFKSKVRQQQQQQRENSITKQEQPQQQQQQETIVLDKCSKTLMMNNDEQQQQQPIFETPVMPITQCSSLNRLKQCTRRKPHQHHSHRHHHHHHRENNQSKKRIGKEKTVTSLRHQRNTNDPSSLQMLPLPSLQQQQQQQQSPVIINSQKLRFESLKSPTATMPAATGGGTIQQKDTTTTTTTVTELRHYKGVGGGGGGIPKTLIKAIKNFLNNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNQ4</accession>
    <name>A0A922HNQ4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNQ4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9498081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="111" mass="13020" checksum="1DFDC43E6B1CBED9" modified="2023-02-22" version="1">MYTMVCMVSPDCNTLVVCCFMYNSLNNTRNTIPYRYLIFVTEVGGERAIVFEMMYRLICFTALTLGIISSTDFRASEYISRKNISHKQLHFNETTSCILPRFLLEWNKNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP98</accession>
    <name>A0A922HP98_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_013010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9496991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP98"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="82"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9496991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="328" mass="39406" checksum="1327B5355087D4FE" modified="2023-02-22" version="1">MEIVNVYVDIFNGTYQLFNQIDGHTFFNDFFNCLIKLFYRNNFFLIEIISLSLAIWIHSIGRHLFTIHIIDKFVKNEIIHEKYRKRFIRFGWNFIMIMLSVAISWKFNTDTGCLKNLSLLWSDYNKIDESLPFIYIAGILIHISYYLYSSYALIYHDERDKDLIVFLIHHMIVIIIATTSYMVGKTYLTSAVGFLLELNELIVSLKILLKLQLQFIKNNVNQIRLLLLSILAIFWFQNRLFIYPYIVLESLQFLQQSCGQSEWNSIYIFIYFLYFFIFTINFHWTWIIINATFRTFQNGLTNIEDDREIVAEGENENFRFHQNVYKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPL8</accession>
    <name>A0A922HPL8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS16m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">28S ribosomal protein S16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MRPS16</name>
        <name evidence="8" type="ORF">DERF_013175</name>
        <name evidence="7" type="ORF">HUG17_6185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPL8"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7643823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9497171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="146" mass="16628" checksum="3B22471EE1D5775D" modified="2023-02-22" version="1">MVWPHKSGFGIKLVRMGCKNRPYYQIGAMPSRRRTGLLPDEVIGSLDPVPNERNEIVAAVDLSRLSYWMGRGARLSVGMQTLLGLAGWTPVPPHVYIKAKQERDQMFKKIQQQQQQTGENEHESDDGDNNEEKIEIESVLPKRLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQS5</accession>
    <name>A0A922HQS5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AN1-type zinc finger protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ZFAND6_2</name>
        <name evidence="8" type="ORF">DERF_010691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQS5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF149">
        <property type="entry name" value="AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9505926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="256" mass="28023" checksum="F53386857584750E" modified="2023-02-22" version="1">MKIFHSFLHKNIEQWNLFLDYDPGTFSVLIIKKMESDPNQMSQSAALCRSGCGFYGNPSNDGLCSKCYKDALKRKQAAPTTTTASTNGTSSSSSQTSLENVAADNIKTLIASSSSINNNNNNNNSSSNIVTSNSSSPTSNISAISAQDSSHSSNSEAKVTDQPNLTTTSENNTSIGADEQDGDETPTKQQKKKKLRCPICREKLAIIRFDCRCGLSFCGTHRYAKMHNCTFDYKEYGAEEIRKNNPQVIGEKVQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQZ6</accession>
    <name>A0A922HQZ6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQZ6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="79" mass="9359" checksum="718FE83780F44B92" modified="2023-02-22" version="1">MVELRAIIKSNLFVQTMTNNQLGFTCGHLFYITKYKYNELILMNIPLILMFYKLFSRNLKKIGIVQPNQIGLNKLTFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HR72</accession>
    <name>A0A922HR72_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HR72"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="10067" checksum="0EF195B3F44D6827" modified="2023-02-22" version="1">MKKRAIQINVIISPNEKHHQFFAYQIIVGENLNTFDYANYIGSINNNNRSISEKENYNEIEEKRQKNLNRNHYYYVTSMNWNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRZ9</accession>
    <name>A0A922HRZ9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRZ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7575" checksum="4317F0EB214C459B" modified="2023-02-22" version="1">MFDAILVFPSTLSSSSSSSSFIVSDIVILIDAIQKKNKQTNTQNIYSFAHSLQPPNHHQDLYFLKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSF5</accession>
    <name>A0A922HSF5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">N-acetylneuraminate 9-O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CASD1</name>
        <name evidence="10" type="ORF">DERF_012564</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSF5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="721"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="806"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="9">
        <location>
            <begin position="324"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9501741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="874" mass="102456" checksum="B1C45E7F5716883A" modified="2023-02-22" version="1">MKSEIFTYGFSDHWMIRNLLSSNNIKKVAFLLTFILIGYHGVLHLTSGVKSCKWLLSDGSFHGFGSYRVWQPYGCMLHTYSKIDTRMCLKYIAYWGGRNHIVFMGDARIHQLYEQFVQSIGVDPPPSSTTTTTIDHHFGDSGYQDKDLNLNIRFLWRPVVNRSMIDQCKHWSSIKDHLKPNIVIMGSATNSIRSSNGSVEALEFYHKNLTIMLPCMESLNRTTRFLWVLQDPIKQQHSGFLRKEKPKTTMITNEQIDLYNKAAMEALRFAKANTVHVWSSARLVAQGFSGEDPINGSNDELRIDPHSLRFSIQILLNLYCNDHMNYNDGTCCSDPEKITAIQCVVLMVFTMIIVISATIYIYSRYFSRQNYFRLRRRQYKWTRLKNDDCEFELIEVNGIFDNNNTEINNNHNDDQQNNDTEEVRIITDQEQQSSTNEKNVPVMKRDLFFPLARLGIIMLYFYLCDRTNFFMKENKYFTRPNFLLPIAYVFALGLFFTDESSKTNVLHTDQTNEMKGWMQLVILAYHYTGASQVLPIYMSVRLLVSLYLFLSGYGHFTYFYTTGDVSFTRFWKVIFRLNFLAVCLCLCMNRPYQFYYFVPLVTFWFIIMFTTFKIIPHVSTQSAESNSSHYFYLVLKIVTLFAIVSLLYTSEVFFENIFLIRPWKALFVTTDDSIKEWWFRWKIDRYSVLFGMVTAFGLQMLRKHQLIWENDTYPYLFTFRISIFTIFAALIGLIFYIALTFICNNKSECNELHPYVSFVPIISFIILRNTSKWFRSRFSLLFAWFGRISLELFLCQYHIWLAADTHGILVLIPGYPVLNVVITSFIFISIAHDIHIITDCIVHCLITNDWRHTLRNLSIICLILLPVGIKDGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSX8</accession>
    <name>A0A922HSX8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSX8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9507126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="373" mass="42506" checksum="806B972DB8B51BD6" modified="2023-02-22" version="1">MVIVDGQLRPPPPPPPTTTTTKPKLSPQPHQITIRRAGNFPIPPPIGSLRGRGSFLLPSSSSSSSSMISTRFLEIIERFLTASATKTTTTTTTTTTTTTTTTTTTTTPKPMIQSSSKLILPPSRPPTTTTATAAKLVINNDRMCKQSDMDLCSQRMLMITDRNFHYPVTMAEMDKRCKELKPIEKCIHHYSERCFESNIQQKSFSLIIYGVTKTNRALCRNNRRRRAFVEFSKQCANRLQRTLITYVEDMYKAMFAILKYPIRKLRIPLSCCNYYRFKNRALTMYQEQCPSHLQQMDRLLSGFTKDSFTFICGRYQENSDRCHRIMDKLPSSNNMTTLLMLINNNNNNKNAALKLSTESFITTYINMIHSIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HT15</accession>
    <name>A0A922HT15_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uridine diphosphate glucose pyrophosphatase NUDT14</fullName>
            <ecNumber evidence="9">3.6.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nucleoside diphosphate-linked moiety X motif 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NUDT14</name>
        <name evidence="13" type="ORF">DERF_012663</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.</text>
            <dbReference type="EC" id="3.6.1.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.45" evidence="9"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HT15"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008768">
        <property type="term" value="F:UDP-sugar diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18887">
        <property type="entry name" value="NUDIX_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000035">
        <property type="entry name" value="Uridine diphosphate glucose pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004385">
        <property type="entry name" value="NDP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00052">
        <property type="entry name" value="nudix-type nucleoside diphosphatase, YffH/AdpP family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF15">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="55"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9501854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="238" mass="27130" checksum="99E904E6B33163B1" modified="2023-02-22" version="1">MSNKNENKNMNAEQENTLEIIDIQSLVNIESPYLKPFRLQYRDHDGRIKVWDCVRTHDSVAILIYNKSRNVLVFVRQFRPPVFLATLFNKFNCSISDLKELQRKSKEMKHDCGYTIELCAGIIDKDGLSPREIAREEVLEETGYNPPIDALELITSCRTGVGSSGSLQHLFYCQVDDSMRVNSGGGIDDESIEVIELSIEAAKTEMFANDEQTGLGRTGGFRFAVCWFNFIKYPQINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HT19</accession>
    <name>A0A922HT19_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HT19"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="8602" checksum="C8EDBFE3ACC63A5D" modified="2023-02-22" version="1">MDHKIFVRFLFDNNNNNNINVKCINFGILFTQTEKKVTKSLNLIYFIVILINLGKRRPGTEKKQRKMTATNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTM0</accession>
    <name>A0A922HTM0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPS17</name>
        <name evidence="7" type="ORF">DERF_011703</name>
        <name evidence="6" type="ORF">HUG17_10014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTM0"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7643323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9507001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="127" mass="14782" checksum="EB762BFBBBC923A6" modified="2023-02-22" version="1">MGRVRTKTIKKASRVIIEKYYTRLTMDFHTNKRICEEIAIIPSKRLRNQIAGFVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALENALIEVDADTYVMLEDLGLTFKKATTSPGDFRSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTY8</accession>
    <name>A0A922HTY8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neurofibromin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NF1</name>
        <name evidence="6" type="ORF">DERF_012686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13313">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05130">
        <property type="entry name" value="RasGAP_Neurofibromin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054071">
        <property type="entry name" value="PH_NF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21877">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="1209"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="5">
        <location>
            <begin position="1534"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="759"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2431"/>
            <end position="2486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2608"/>
            <end position="2690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2874"/>
            <end position="2916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2936"/>
            <end position="2990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2434"/>
            <end position="2456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2608"/>
            <end position="2635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2645"/>
            <end position="2654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="2657"/>
            <end position="2689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2891"/>
            <end position="2916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2953"/>
            <end position="2974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2975"/>
            <end position="2990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9501877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2990" mass="339874" checksum="40F5F79F8A0A8BE3" modified="2023-02-22" version="1">MANQKPVEWVTSLLSRFEEQLPYRSGPQTSQTRVNVEQIKETLIQISKTKFSLVISGLTKTLHTVNEMFISQRSQIHGPIQPEFERNFYESQLLLLDTLEKCLSIQPKETTRYDETMNVKALLKEICHFIESSNDNIMAAQLKVLASKVLFSLSLNNFNAVFSRISARLQELSNTSEENMDFIDIELIQYINVDINRLLKLLLEINLKFRSLKKNAHYILLNNVEKAIWNWIETYPQEFMEYQCRPNEELSDCCDKLFEHLDSYAENNNKRKNFVWPLQILLLLLCPKILEEIVNADSGAPFSSRHQRKRNFIENVKKSLVPHSSSKQLTEAAAITCVKLCKASTYINILDSNNVMFTLVQSVINDLKLLLFNTKPLIRSPSNLYNDVELMIECFVSIFRITPHNNEALKVCLNPNCPSMYHYVLVCSLFRIIVQPRLSWWPKIDIIYNKAPELRFMFTETLIKATQGCISHTPLRMIQSFTLKEKVTTLKFKDKSSEEGLNFKNLLLWMVRLIRVNPILMLNNQGKAGHEIQSNTLELINGLVSLVHQPSMPDIAQEAMEALLVLHRPENIELWNPEAPINTFWDVSSQVLFSISQKLIQHQIVNYTEILKWLRDILKQRNYFLLRHKDYANIGSHVAICKQAHIKLEVVLFIYLWSIDIECVLVAMSCFALLTEEADIRCGQDDLTDTYSLPNYHVYLELTNASTILTTGRAALQKRIMALLRKIENCTQGCSQAWEDSFLNWDSTTKFLVSYPKSKLGDSEQSDGLHRNVSKRRASHQSTEHELEDQINEWANMTGFLCALGGVCFKKSANKSSSFAMNIIADTNKKNLVLPNCHDSLQYCPVTQFVGVVLKLLVCHNEKFGTQIQKHVKDLLAHEMSPMLYPILFDQIKILIEKFFDSNGQVQLTDTNTQFIEHIIFIMKSIFENKSEHTTENLGQTTSIEHIMLAIVRYVRHLDSNNNHHIHIKNKVCQLVEAMMARRDDLSFRQEMKFRNKLVEYLTDWVMGNSHQMQPTVYTDLTSLLRDLDQSCMQAVAALLRGLPLQPEESDRGDLMEAKSQLFLKYFSLFMNLLNECSEVLSTEDTVSNNSGEATRCTVAAARFQSSTSTKLSELRTYTIQAMSNLLSANIDSGLMHSIGLGYHKDLQTRAAFMEVLTKILQQGTEFDMLAETVLADRYEQLVQLVTMIGEKGELPIAMALATVVVTPQMDELARVFVTLFDAKHMLSSLLWNMFYKEVEVSDCMTTLFRGNSLGSKIMAFCFKIYGSSYLKNLLEPLIKPLLDSAPNTSYEVDSARFDDNDNVETNRNNLMALTQKIFNAIISSAEKFPSQLKLMCHCLYQVLNKRFPNFPHNISAVGTVVFLRFINPAIVSPFELGIIEKQPAPKIKRGLMLVSKILQNIANHVEFSKEQHMLCFNDFLRTNFDAGKRWIYQIASEVEIVEYQANHNISFISDANVHALHRLLWNHQEKIGDYLSSSRDNKAMGRRPFDKMATLLAYLGPPEHKTISESQWNSMEMTSTKFEEIMAKHNMHEKDEFKSIKSLNIFYHAGTSKAGNPVFYYIARRYKIGETNGDLLIYHVILTLKPFCHKPFELVIDFTHTCADHRYRTEFLQKWFVVLPEIAYEKIVATYIYNCNSWVREYSKYHDRLLVPLKGSRKLIFVESAQKLSEYIDIEQQRLPGATLSLEEDLKVFNNALKLSHKDTKVSIKVGPTAIQITSAEKTKVLGIPVYLNDVYYASEIEEVCLVDDNQFTLTIANESGPLSFIHNDCDSIVQAIIHIRTRWELSQPDSVTVHTKIRPKDVPGTLLNMALLNLGSADPNLRTAAYNLLCALTGTFDLKIEGQLLETAGLCIPSNNTIFIKQISEKLAMNASHLTLEFLEECIQGFRSSNIELKHLCLEYMTPWLPNLTRFCKQTDDNKRQRVATILDKLITLTIEEVEMYPSIQAKIWGNIGQISDLLDLTLDSFLKRSVTGGLGSSQAEIMADTAVALASSNVQLVAMKVISRLCRVIEKTCTSPTSTLEQHLMWDDIAILGRYLLMLSFNNCLDVANHLPYLFHIVTLLVHIGPISLRASIHGLVINIIHSLCTCTKPSFSGETQRVLRLSLDEFSLPKFYLLFGISDVKSAAVTAFRTHPTLNYNRHYCTDRHYNNLTQDRAIATMNENYDRLPLNSLETITDALLEIMEACMKNIPGCDWLQRWTEMSRSFAFRYNPALQPRSIIVLGCISKFTTDKEILGLLRILVKALESFQDLQLIESIIMCLTRLQPLLNPDSHIHRALFWISISVLQLDEISLYASGLALLEQNLHTLDSSTTFELNTLKSVMMATREPLEWHFKQLDHSVGLSFKSNFHCALVGHLIKGFRHPTPTTVSRTTRILNMLLEIVAKPHKRDKFEVNLESVPYLAALLPVSEEVQSRVHLRHRVTRMILDRTSSKNYPTTNEIQQNQTTHNPPHTQSSNVNGAGSGGSNTKLLNISSSSSSSSPATMMTIQQTLAPSPLSSPSTLMNLPLSSYITQPHKVMFAQTHQQYYTTTSSISSSNPNTPTIIKTQLKPNLSNHIAATVLHSSVSPNSSINSNCTSSLDVDDKHWKSLDSESLTSSVYRPLFRTQRSSSMPSPKIANNSKNGELFDNNNLFDEQSLKDSQEQQQKSSSSSNHDHHKHHHHLVDIHHNHHHHHSKHDPKQTNRKSRLSVSNENNILLDPDVLIDFQNQALILTILATLVRNTTDESEMRTLYEYLAEASVVFPKVFPVIHSLLDSKITSVLSLCHDKVILSAVQCIIHNMVLCNEEPQQQSHCLQTFGFGGLWRFAGPFLKSESNLDNAELFVNCLEAMVETCLTVDENENDINNEYMSEYSSTLSLTSTMNLSSSILSVTPPNEKDYHQNNNHHHQPNNNICDNNNTTNTSTTTNTSSTSTTTTAAAVVATKEMLATANSFNNLSMNKDRKESQPPPSQTSSSSIIKHNSSSTSLTNVLSPQNSLKFNKSNPLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUT1</accession>
    <name>A0A922HUT1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_011128</name>
        <name evidence="9" type="ORF">HUG17_5908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUT1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="35"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7643546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9506390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="223" mass="25413" checksum="C2F0B8A53E20E9A5" modified="2023-02-22" version="1">MKSFHLILRRHLSSQSWMQRHVRDTFVKQSRYQNYRSRAAFKLIEMNKQYQLLKPGMIVIECGAAPGSWTQVIVECLKLKPPECHKTGAVIALDKADFATIPGAICLPKTDFTSHISQARILSALNDRKTDLILSDMSPNVTGQHDYDHERILQLVYSTVRFASISLKDQGNFLTKIFNGNQTEKLIEDLNLIFQKVQKIKPEASRMDSTELYILATGFKGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVD7</accession>
    <name>A0A922HVD7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010115</name>
        <name evidence="1" type="ORF">HUG17_0143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVD7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7644605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="118" mass="14035" checksum="B4C713B6443A255E" modified="2023-02-22" version="1">MSFHVFNVPMYRNKSSSKFRWKIGHGSDELVVMIDIYGKLRNNTMWIVKFPKEMSAKYPTNTEFIYRDLQRTGYSPIVEEKLQELRNQIQIVSERDGVPANRWDLTAYYGKPGFEFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWG4</accession>
    <name>A0A922HWG4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWG4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9510514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="349" mass="40285" checksum="9E5C835C1E6704BF" modified="2023-02-22" version="1">MKGLSTNRTPVSSSSSSSSNGSMMMVPYFRISKNSRLQKSNQIHIRQSRSSTMMICNDSNTNNINSTFIQQQQRCNRLFCLMIIILTCLLFLLLTSSYSSSQHLANRYNIDNSPNNMDGDLSHAVDVLGSSATAVAAAAAGAIIKNHHDDDQQHQTKSMINSNNKSRTVDMTASHQHQQQQQQPNDRSNRLRSRTHDDGYHNQNNELIESVKQFSHFKQQQQQHHHQPQQTSNISLLSKESFWHQQHQSTQSQMKDRFIDLQQMLRFVLEEQLNRTERIRRKHRKHHHQQQQQQFSLPDTAMVNNDDDYNTINDDDNNNDDDNDDENDNKINRLIPTSSISTNSLDSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXU2</accession>
    <name>A0A922HXU2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sestrin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SESN1</name>
        <name evidence="5" type="ORF">DERF_010050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sestrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXU2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070728">
        <property type="term" value="F:L-leucine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016684">
        <property type="term" value="F:oxidoreductase activity, acting on peroxide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071233">
        <property type="term" value="P:cellular response to L-leucine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990253">
        <property type="term" value="P:cellular response to leucine starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901031">
        <property type="term" value="P:regulation of response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006730">
        <property type="entry name" value="Sestrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474">
        <property type="entry name" value="P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474:SF0">
        <property type="entry name" value="SESTRIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04636">
        <property type="entry name" value="PA26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9511601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="500" mass="58038" checksum="253501FEAFC6E0FE" modified="2023-02-22" version="1">MFVNLVDKNKNKKQDKMSNKYRQQQKEDYLEKTFTEYIGCHPTYTIPLIRAHNFIMRDIGPINPAVRYYVAIMAASRHRCSYLVHFLRKQFLIIGGDADWLKGLEYAPIKLQSLNTINKILAHQPWLLKTTHIQVLFGQSLTKNINSWTLPELTHAIIIMAHFHSLCSLAFGCRFGYEPPECNGEEDGEYEEIEIEELRFDGDSGSSTIKKIVKRSPASRLIVERCRQLEQEDANLAKIMNSFTLATAATSGAGKRKHNKYHHNNNKSSSNTVTTETITKHNDNDNNDGTSGSNSTTKIDSKPMITVLDNGEFKPNTWSEDEWQKHNFNVYIDDPEFVYIDFAKRGRTSESSTYRIQDYQWDDQGYSLSNYLYPDVASFLDEKFKVGYNLTYYTLGPKTNIDTSPFRRAVWNYIQSIYGIRHDDYNYREVNILLERQLKCYIKHLACFPQLTSRHDFRSVMKGFRASEKVHVIIMVAEARLQAEILYAMRTLMEYMKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HY09</accession>
    <name>A0A922HY09_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HY09"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7393" checksum="79AC9828E4EC1DE2" modified="2023-02-22" version="1">MIKFSIGSMSTIVTTIQQQQQQQPNRNGMTTSLSASNYKFSIIKKSPPTTTATTTFATMTSMNNASIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYB8</accession>
    <name>A0A922HYB8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Epidermal growth factor receptor kinase substrate 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EPS8_2</name>
        <name evidence="6" type="ORF">DERF_009064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYB8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF23">
        <property type="entry name" value="AROUSER, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="50"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9510541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="404" mass="44018" checksum="83BF057E589B02D4" modified="2023-02-22" version="1">MANKIYTDQEEILTSRSLSMQNNNNKSRSHSHPTSFDDSDYEDQQNNNGDNNPRIIAHHHQHHKHNSSTRTNNNKELTVTRGEILEILDDSRKWWKARNSRGQIAHVPHTIVGEIESNICFWYRRRCSAVVKVEVVAGLFIADLAVVVVVFDAVVERFVKAVRVGLAAAAVVVPLVVLLDAVGRFVKPVERLVAVDRDDNAVLVTGFLSAVLVIAAGLLPVVVFVLFEDLVAVVKRDDIAGRVVAVIFGAKVFVPATVLVFDVLPVVAVLIVAFDGTVLLTGTVTGATEEDKDLLTRLTSSSLLPLISITSDDDSDMSILESSISLTILLSNLPNKSPLGIDLSVIPLIISSLMFRKTGALISSVFCNEIFDTFSRISFIFSSWLVVFIDCSISSSLAVATAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYQ4</accession>
    <name>A0A922HYQ4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_007830</name>
        <name evidence="2" type="ORF">HUG17_2138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYQ4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7646600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="86" mass="10034" checksum="A948C37825130671" modified="2023-02-22" version="1">MVTSSEDIDDDDHPTPDGSKTSRKKVFMNWVSTASSNFISWFCFVFYSLNLPKEEEEVVNIKVKVRPNFEQTTNQQSILIHFILYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ94</accession>
    <name>A0A922HZ94_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_010415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ94"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9511999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="79821" checksum="CE9E83E114B64189" modified="2023-02-22" version="1">MTNHRQWYRPIIFRILSNAKRILIIIVLTSMLTSWLLYCWVYSNPLDVTTESSSDLDHRNNYYYFQYSSYNNNRTSPFSFDGYDNDSFVFDTNSSLSNTNPILRTGRLVTYNNRIQKSIINIENDSYNSTVAIQNWITKCQPYIARYFDVCQKTEQSISDDDGDDSKTAELNTHVQLPDYSDHSLPINGLSDRLYLYQAYERFEQNDKYSVVIISIVNRSIYCPDDDNDQLQQNDENQLYCQLQINGNVILSKANLQCLPEHHNYLYTAAVIKCFPSSSFISSFDFVRIRENLEQSKWLPIHNRQKYSNKSIQSVVCVRPLFGSINVLNLFEFIEFYHNQGFDRIIFYHYANGNFTGKAKRLLFYLNETMSYIVQMKSIPLPRFIWKQIHSGGQLVTINDCLNQYPNAIQLHVDIDEFVSLSNGESERNYNMTIMQMIRKYWYESKTSYIALYIANVLHCHEFNLAHSNYYEFTAARQKYPFGSIKNDDQCYDNDQTNQNGHKNLMLAQLLDNHVTNMTIEEMKSLLLVPNSIFFQATLWPYQLRSKVIILRPWLIDLMGIHHVWKFRHDYDIIGNSFVDQLSYMLRSKWTIDDKQILFTFKNIDKNQLLLRHFRWCCHLKQPYWLQLFQFDSLDDQVIRWKQKNLADWSTIGHKVFQHYNQFRFNHNTVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0H9</accession>
    <name>A0A922I0H9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0H9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036919832" evidence="1">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="131" mass="14760" checksum="A2C8D3A559566F59" modified="2023-02-22" version="1">MTMNRLILTSTFTMIIFELIMAMGDSTNKFGGPLFVEGSLNDVNKLWKCADVISNPAAVRGELVNRKMKGDQKIRRFIENCIKWGDGWRFKKDGTSLNFRFPSSSLSMTDYNDNANGSLDAKIESAINDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I181</accession>
    <name>A0A922I181_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I181"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6738" checksum="5886BE4F8169DC8D" modified="2023-02-22" version="1">MIEFDRFCCNLSEVSINFIKQHFQIDYRSLLGPTVAESMGLHKSINENKTLTSEAAFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1T7</accession>
    <name>A0A922I1T7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylmalonyl-CoA mutase</fullName>
            <ecNumber evidence="3">5.4.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_006659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methylmalonyl-CoA mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1T7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019678">
        <property type="term" value="P:propionate metabolic process, methylmalonyl pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02071">
        <property type="entry name" value="MM_CoA_mut_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03679">
        <property type="entry name" value="MM_CoA_mutase_alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.280:FF:000002">
        <property type="entry name" value="Methylmalonyl-CoA mutase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.240:FF:000001">
        <property type="entry name" value="Probable methylmalonyl-coa mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.240">
        <property type="entry name" value="Methylmalonyl-CoA mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058549">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006944">
        <property type="entry name" value="PRK09426.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101:SF4">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="Cobalamin (vitamin B12)-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="8">
        <location>
            <begin position="603"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9515885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="743" mass="82964" checksum="124D4BF788D287FA" modified="2023-02-22" version="1">MKYLNYNFHYKKVFSALINRRSLSSNVMREEWKKMATKQMKGKDPDTLIWKTYENILLKPVYFSEDRAQDPQNELPGKYPFTRGPYPTMYAQRAWTIRQYAGFSTVEESNRFYRENIKAGVQGLSVAFDLATHRGYDSDDIRVQGDVGMAGVAIDSVEDMKMLFDGIDLKKISVSMTMNGAVIPTMAFFIVAGEESGVEQKYLSGTIQNDILKEFMVRNTYIYPPDESMRIIGDIFSYTSKNMPKFNSISISGYHIQEAGANSLLELAYTIADGLEYCRTGVKAGLKIDDFAPRLSFFWGIGMNFYMEIAKMRAARRLWAHLMTKYFQPTNSKSCMLRTHCQTSGWSQTEQDPYNNIVRTTVEALAAVFGGTQSLHTNSFDEALALPSRFSARIARNTQIIIQEETGIPKIIDPWGGSYMMESLTDELYNDALKIIEEIEQMGGMAKAVAQGIPKMKIEECAAIKQARIDSGQEVIVGVNKYRLEKEEPIDVLMIDNKQVREAQIAKLNQIKTTRDEEVCQRSLDALTEAARGDGNVLERAVECAKNRATLGEISMALEKVFGRYTAVDRLVSGAYYNAYSESEVLKKIQDKIKEFEAVEGRRPRILVAKMGQDGHDRGAKVVATGFADVGFDVDLGPLFQTPEEAAQQAVDADVHCVGVSSLAAGHKTLVPLLADALKKLGREDIKVIVGGVIPPQDYDFLYKAGASAIFGPGTPIPHCAIKTLEVIQESRNKNDKNIAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1W7</accession>
    <name>A0A922I1W7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_008567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1W7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF148">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9517954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="181" mass="20726" checksum="8838F800D368D133" modified="2023-02-22" version="1">MQQINKSTGQSKQNKKKMTELTISEPGFKDVWLRKFQIFINKFIFILWTGILIYAVGPYYSIRELFRHLQIFGFKKLDYSKEFGDIDLHGKICVITGGTRGIGMEVCRYLVGKNCQIITATSTLKDDANDMMIEQAKRKLITKIDPSLLSSNNRNQITLLPLDLSSMDSVAKFATQNQDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2J9</accession>
    <name>A0A922I2J9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2J9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="371" mass="41794" checksum="1B3DDF284EC093CE" modified="2023-02-22" version="1">MFHSFFIISFIKEKKRKLFDAAKQRAENLDKINLVPTDINNVNSEQQTNQSKSIRKLKNNKRSTNNNNDNDTAATNGMKNQEALQRMKARTKYKPTPPGNNNNNDKLISRSKSITTLSSTGSTISSTSSTPSTSTIRSTSQDNLRRPQQQRQQQQQHPTNGINHRRNNAKILSKSTDNLPNAIKKGKTTTTTTAMNNSKISNNNNKSPSMSRRTTTTTTTTMNNKSNNKKNIDRNNNQKFTTTTTKKMTTTSNGYNPKLSVSSKIDSGINPDRNQSRNRNNNHHEKSAPIMKFKEKFPNHHLNNHAKSIIDQFHDIEHILRRNSMAVYDDSPKTVPGVRTGGISPIKKSNNSNSHHDDDHHHGTILSKIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2K5</accession>
    <name>A0A922I2K5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">A disintegrin and metalloproteinase with thrombospondin motifs family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_008130</name>
        <name evidence="4" type="ORF">HUG17_2379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2K5"/>
    <dbReference type="OrthoDB" id="6511864at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF249">
        <property type="entry name" value="SOL NARAE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324698" evidence="2">
        <location>
            <begin position="23"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="3">
        <location>
            <begin position="247"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7646841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9517457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="510" mass="58916" checksum="82067ED4E484EE68" modified="2023-02-22" version="1">MLTINAIFLYLNIFFLANSINSIQIFTSKHRVPTIVIYINDHHDGTETISHNVRNTSNQRYGRNWHSKQIFVRLHHHVSIRHDDDENYQLRLVNGTNRHRTIHVRRFNLSNSILHFPSSTFQTIESKLATNQSIRMIRFQDTNVTTNQTSQIYTSRDYSTFLLVTIDNGQNVNNGNDSECMIRMYGLIDSQMMIMPLQNQSSTSNFHRITNGEQFGSLFEKSIVTSSNNLLWQSLAILKQPQPIHHIYPEITLLIDYRIHRMAHEKNVQFTWRYGVMFVQMLQSLFFRTIINQNFQIHLHLKQILVAEQPWPFESIRPQLKGSLASNNKTANRPYLNALHALRAFGHWIYNHTADVQSDLILILTGHDLCLDDDHDDHSCSYSSVKGQAIVGGACRHHHHHERRRALNLAIVEDNDLKMVDGLHAMAHEVAHLFGAVHDGEWPLTTIGGPGGTNCRDDDSFVMSMDHGSIVDPTTNQLRTEWSKCTLEQFQHFFSKPHSICLFNEPTINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2L2</accession>
    <name>A0A922I2L2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2L2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="84" mass="8972" checksum="9685CFB9CC475C34" modified="2023-02-22" version="1">MNRADQIYKQQQQQINQSINKSINFQHLCTHLYVTGISATLELAVNAAAINVAGAACCERLLNAVIMGNAVNDAAAVDVASNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2N1</accession>
    <name>A0A922I2N1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ovarian carcinoma immunoreactive antigen (OCIA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Ociad1</name>
        <name evidence="4" type="ORF">DERF_007056</name>
        <name evidence="3" type="ORF">HUG17_1538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2N1"/>
    <dbReference type="OrthoDB" id="6513616at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040187">
        <property type="entry name" value="OCAD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009764">
        <property type="entry name" value="OCIA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13336:SF3">
        <property type="entry name" value="OCIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13336">
        <property type="entry name" value="OVARIAN CARCINOMA IMMUNOREACTIVE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07051">
        <property type="entry name" value="OCIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OCIA" evidence="2">
        <location>
            <begin position="80"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7646000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9516305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="267" mass="30556" checksum="A252351E257A38FE" modified="2023-02-22" version="1">MSYPHGNRDHSYQNRDDPPDLIHDPYGTPSMYRNPGTQPNVSDQQHQQQFIQQRPFSPKNNQIVAKNYNDFLERQGIPAISPEDIRILRECGRESLIYRSFPITAALCTALIYTARTRQIQPRFYHYLGAAFFGFFAGKLSYRSVCEDKLIKSNSNSPFVQSIRKRKGLFFEGYYENVPQGFDSSHPSSASPSFGKPYVDDSGSHTGIREFDDHHSSSFNQNKDSYIHDPFGSGQPSLDFPTDIGDNRGSISYDDLRTRNRSEFKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I335</accession>
    <name>A0A922I335_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I335"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="134" mass="16376" checksum="AF09B05E1F4BA027" modified="2023-02-22" version="1">MDQNSIDANGKSWICPTFRSIYERYAYLMAPYITPNDNTGFQQRIEQSIMESYRVERDYLHTIINRLECKINILRIEQNELIQWICYHLQTAEQSSRYNDAVKYYRILYTREFYRYQVFGTFYIDQNEIQSKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3N5</accession>
    <name>A0A922I3N5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dgcr6-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Protein dgcr6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DGCR6</name>
        <name evidence="3" type="ORF">DERF_004378</name>
        <name evidence="2" type="ORF">HUG17_0500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gonadal family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3N5"/>
    <dbReference type="OrthoDB" id="21617at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010849">
        <property type="entry name" value="Gonadal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054">
        <property type="entry name" value="DIGEORGE SYNDROME CRITICAL REGION 6 DGCR6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13054:SF2">
        <property type="entry name" value="PROTEIN DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07324">
        <property type="entry name" value="DGCR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7644962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="201" mass="23282" checksum="BBA53C8B47771839" modified="2023-02-22" version="1">MATTTNISSSDTNINNQLAFDTANSETHQYYLDRLKSMVENDNSSHMKKYINDQLLSDLATSLLDQTVINILIMLRLQQVNNERELMQQRDSMIAKLDAKRNSKIEQVEKKFANGEITSFKRDDLLKEMKKHYEEKIVSIDMHLLNLVDKNVREQQKTLMDAEIPGFHITNNSHEIEAQVKLLNFIEQIINLSDESKLAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3W7</accession>
    <name>A0A922I3W7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008746</name>
        <name evidence="3" type="ORF">DERF_008758</name>
        <name evidence="1" type="ORF">HUG17_4868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3W7"/>
    <dbReference type="OrthoDB" id="6536468at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7641823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9518149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9518162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="102" mass="11321" checksum="0A8599F8A0B60447" modified="2023-02-22" version="1">MVQQQGPKIDGDEPQSLLIDISSNTDRSISELEQSVKQMSIKEESPSMKTCHDSVIQTGGAIDKNLLQPNIMTTSFDSSLMHSTSPAGMAQQPQYYQQQIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I507</accession>
    <name>A0A922I507_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TUBB4B</name>
        <name evidence="17" type="ORF">DERF_005278</name>
        <name evidence="16" type="ORF">HUG17_3673</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I507"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7639640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9521642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="446" mass="50088" checksum="09B16B262A533BBD" modified="2023-02-22" version="1">MREIVHIQAGQCGNQIGSKFWEVISDEHGIDPSGSYRGDSDLQLERINVYYNEASNGKYVPRAVLVDLEPGTMDSVRSGPFGHLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEGCDCLQGFQMTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLKLTTPTYGDLNHLVSVTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQLYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFRRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATAEDEGEFEEEEDPQQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I564</accession>
    <name>A0A922I564_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
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            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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            <taxon>Dermatophagoides</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </evidence>
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                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
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                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
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                <person name="Malainual N."/>
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                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
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            <dbReference type="Proteomes" id="UP000790347"/>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1" key="1">
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                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
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                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
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                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
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                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <tissue evidence="1">Whole organism</tissue>
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    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="768" mass="91597" checksum="CF77921BD142B997" modified="2023-02-22" version="1">MYLKIRHLCYNHAKEIFEQYHTTGYRIKHSIEITITNFWLIRMSLAIFSYRRQELNYWLYDPCTVLFHYLNPNLHIHYTCILAFILLTTIIETYFIFFYRTNPSVYQYLYDLVVVNTKQITHCYYPQDMITQMVEKTYRINLKIFQCNNMIFSHTSPLHHIGQFYCWHMTKIQFKLQLKHLNRRKLSSFKLKSLPYLSIKSRSMLQLGLYCMDTIDFFLVIALIFYYYTIWNIFHLTHWYHHLLLLVEIAIILYDTFLTFQLICIISTLNILVIISFCSIQLETINNLLKCIHIQSSNRLKSQTLNLLSSLYLEHGKICQFYMIIFTKLYGKMIFIFLSFTLPMNVLFLIVFCTKNLSWIEKMQIIAIFCFHSFILIQSQLSLAMQTEVIHRPEKYLVSIIQNVTRLRLKMKLADLHYRLTQGPKYGPIISLFGAITNRIVLEVNHSSPLHHIGQFYCWHMTKIQFKLQLKHLNQRKLSSFKLQSIPYLSIKSRSMLQLGLYCMDTIVYYFHFFIGFFAMPAMIFYYYTICDIFHPTHWYCHLLLLIEIAIILHNGFLIFQLIWIISTLIVLLVIAFCSIQLEAMNNLLKRIHIHLSNRLPIYSKSRTFNLLSSLYLEHGRICQFYMIIFTKLLGKILLVFLAFTLPMNVLFLIAFCTKNLSWIEKMEIAIIFCFHSFILIQSQLTLAMQTEILHHPKKYLVSIIRNVICLRLKMKLSDLHYRLTQGPKYGPILSIFGAITNRIVLQMVIIYIGFLIFILSNFQNIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I788</accession>
    <name>A0A922I788_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I788"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="36" mass="4092" checksum="471E78F9D421A322" modified="2023-02-22" version="1" fragment="single">IQQTTIFCLFINDDDDEHQQTSCVAGFSCIRSLTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7A0</accession>
    <name>A0A922I7A0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FAM63B</name>
        <name evidence="5" type="ORF">DERF_000390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MINDY deubiquitinase family. FAM63 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7A0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140934">
        <property type="term" value="F:histone deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="4">
        <location>
            <begin position="182"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="581"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="632"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="656"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="698"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9526291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="733" mass="82456" checksum="C40BA02B2DFD2E66" modified="2023-02-22" version="1">MSLPTKKISTITNDDDHKIDDNIDQQQQLIEIVNKNENEKESVIETVNTSIDKTLLPDNDESLCTDTVASNNPTTAFNIIDDLETSLVNNFTVADVPKTASTSEISSTNNNNNNNNNNNPVDSNDSNSISTQESNIESSDPNEDHLKPELSTSTTGLDPIATESTISTTQTNSVSNLSSQEYHLKWIKWKVGNSGSNGSNNNNNNNNGNGNGNNSQPQQQPQKVPIVTQNSNGSCPLLAIINVLLLRKNITFPPIIEIVTASQLMDYLCDCILTYVPKNLPEQDKLNYEQNLQDAMSIMPRLQTGLDVNVKFTGIMDFEYTPECIIFDLLRIPLYHGWLVDPQQREISRVINNQSYNQLVDRIIGSKTTNSNDNEMFLAEEFLNQTASQLTNYGLSQLIRHIKDEEISILFRNNHFITMYRHKGKLYQLVTDQGFLTEPNVVWESLNNIEGDDYFVDADFQLVPPKPLTIPMPLSSSSTMTTQLPNLNIQQQIDQDYLIALSLEQEQNFEDQQQQQRNVKSRNFADNNNLNKTSIIDDNQKTLLSDEELARKLQAEEDQYYEQQQLRQQPKKLPTTHENKTYASVVSSSQQQQQQHTMKTTKDSKSGNCLPNHYQISSSSDIATCNTNAITTSSCHHPQSSTTKSSSTIPLSGHYQQQHPRTSTSSSSTSSHHHQHKQQQQQHTNPSHYQRSTSTEQSASTPVTPTTTTSRTIPDDRHSVSSRRSQNKNCTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7I1</accession>
    <name>A0A922I7I1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_006295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7I1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9522733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="95" mass="10128" checksum="E6EFCD028648AA91" modified="2023-02-22" version="1">MSENEGPVVTDSAGTIQDDMMDGDNKQYSRYNDRRGGGGGGGFSRNNGSRCYNCGQFGHLSYDCRKPQMSGGGGGGGGNGMMSFRSRNNQQKLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7R4</accession>
    <name>A0A922I7R4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7R4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="10279" checksum="2D2887A34A6564B2" modified="2023-02-22" version="1">MKRKEKNRHGSSSYNDDDPCCIIWFCNSGLRHYYYRLYRWYRFCSGNSTSNKREIINDDIYGCHLVTFQHSLIHSLTQLTYTQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I807</accession>
    <name>A0A922I807_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid phosphatase det1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DET1_1</name>
        <name evidence="3" type="ORF">DERF_000003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I807"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019138">
        <property type="entry name" value="De-etiolated_protein_1_Det1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374:SF3">
        <property type="entry name" value="DET1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374">
        <property type="entry name" value="DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09737">
        <property type="entry name" value="Det1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9525868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1068" mass="123088" checksum="2A0CC9AEB920E2F5" modified="2023-02-22" version="1" fragment="single">TVNEIAQIAIKPTGKPTPTKILVNRRKTLRRSLSYDTLPKMKNKMIICQPMTIQRRITVPPTNKIIFTTHKTQHLVLICLAFISFTSMLAMAIIAPFFPTESAKKGMRESVNGLVFSVYAFVFMICSPIISLMIPFRNIHSILFYCANIRSSRCGTAFSTSTYTILMEEFPDNVGTAFSIVETSVGLGLSLGPAIGGFLYNIGGYGLPFYVLGTIMLVNIPLCYNISLLLLIDCERLKSPMNAYFRLLSIIKVIINCCVIVVVAQSLSYLDPTIEPHLRSIGLGTNLVSLIFLILSATYTLSSPFIGWISQMVPNKFQIMAIGLLLMGLEFLFLGPAKMIPMETNFTQTAIVMALIGISYSIAFIPTFETLNNLALKNGFPDDVTTYSLVSGFWTSFCSLGEILGPMFGGFLTENFGFKQSSTIMGIIAIIMAFVCGITCIYYDELDTHDHNHKNRGNQRQKSLPQNRIISNRHHGKQSLARPKNILTNNGKQYESSEMIPLFPKRKRPRNNIVHRLFDREYNLHPRFHPFVFNNKLHQNVVPNFSIERAEHPNCFLRKFTYDGRYLMAFSSDITSVELYEYQGAAAAAQLLHLIPSGDKDYLSYGDENAEIRRKIFSCFFKRRHTITVAMDGGQLSRECSLFTDDNRFLIVASISSTSEATTSFHDRYQTNESIPMSHRSTYEDYKFHIIDIDAGRVVDSIEFKTDKIQIANNHGIYLYKNVFAILSVQHQIIHLYYILPNGEFIFNRKIGRFCSEEDRLLFEDSLIQSMYRRLNQPIPVSHRPVAAFREIPFNALKHRIITFAFLQAKRQSIEYGSPKPLCQFYHDFDYLVNLRMLKMQLLDEEHLLIKYEQEYSLVTYNQFIISKYDTYNQTKLWNLFVVYNWKTTEVINIYPQHSQTLLYAYENFCNYFRHPYGYYPCSPSNNYYAHVAYEVFKQSIIENRNGNYSEAVRCILSLLPHHAQLLTPSPYLDLSLFSYDEKVIGLNEKPRHTSDEPIRFFNRNTDRLSFRMHTGQPQRLPPLLIPLPNNRRLIAFIFHPTDPFIISVQRYNSQYLLYFHIRHFNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I875</accession>
    <name>A0A922I875_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I875"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9525973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="89" mass="9292" checksum="E201BAABC826BF78" modified="2023-02-22" version="1">MTKFFSAQFQMETTENSTRDLVLLFGITDVDDDDVCDCVFVRIDNGGGDGVGVDKWTTKFDFLVDKKVAGGGGGGGGGGGIGIEVKGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8F5</accession>
    <name>A0A922I8F5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8F5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="94" mass="11019" checksum="D88049885200A88A" modified="2023-02-22" version="1">MVIILHLPSKRIDSYQLTTTMTTKILPQINLIKLKKIDVIFKRCYQVNPRKRQEKMKNDPNCATLLRTILLFRLFIIVDDDATGLEFIISLDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA98</accession>
    <name>A0A922IA98_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_000493</name>
        <name evidence="4" type="ORF">HUG17_8296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA98"/>
    <dbReference type="OrthoDB" id="6510547at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324716" evidence="3">
        <location>
            <begin position="22"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7640827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9526395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="310" mass="35771" checksum="BCBF0266D0800FFC" modified="2023-02-22" version="1">MNLNFWSLSSAFYLFIKFTAAHLDQQCNFSMCLNSFMVPIQHAYCDNNNRCRCKDGYVPVSHHQCVETQYPGKPCENDNVCRFKDENSFCDTNRRSPICECKKSHIYDSEQKKCILYVKKPKKSTPLFPMTAIILIACIGIFCGCGIICHNFRRQPELSVSVDHIDRYASERRQTLNHHHHHLPHHHHNHYDDHTNLAGSSRMNNNSHNDLSDSDLAITNPPAPLLRSDSHSTSSKYDSLMYDDPPPRYEDAIKEYHDSIVNESPTNNNNNNNNNNTFMDQQQQQQQQQQQQQVQQTTIGFCTVMAATKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAF6</accession>
    <name>A0A922IAF6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_005890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAF6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF116">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG5065-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="7">
        <location>
            <begin position="110"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="7">
        <location>
            <begin position="347"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="6">
        <location>
            <begin position="508"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9522303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="777" mass="89857" checksum="671B6EF33497ADB6" modified="2023-02-22" version="1">MSPNNHPNDKQQQNEIMMNFMHPSSSSSSLSSSSSSSSDPSASIMSKPGLIKLKNNNHQNDYGDDDYKEHTATITSESGIDDDYESSSSEQCPTLVPTLEEFYDGQSVFITGGTGFVGKVLIEKLLYEFPTMGNIYVMLRPKSGQLIRRRLEKLTECQVFDRIRQQYPERLQKLKAISGDIRYPGLGINPIDLQTIRDNVSIIFHSAATIRFDEPLKYALLINTLGTKRVVQLAKKLTNLRSFVHVSTAYCTVDKRKIDECVYFEPISPDKILEMADWMNDDTMNRLTKTLYRGRPCSYHYTKSLAEHLLAEEVANGCFYQSKTKNTTTTTIMDDDNIESNDTKWRPFPAAIVRPSIITPSWNEPFPGWVDNYNGFTGFLVVSGKGILRSMNVQKDYLCDLIPVDVVINTCILSAWYIAVHHYKHSKFPRTLTTSATTMSDNRQCSDNNEIFVVNCVTGAHNPITWNQLRNISMPLMCRYPSMEMFRVPNVRFHRSKMINQINVYLEHTIPAFVVDFLFKFMGFSPILNQVYQKVHRVTDALEFFTTNEWTYTGMNMLRLIEAADYAYRNNQRKELINKTLYVDGEKQLQKLHEHQQQQQSIMDVSERFPIDIRKLNWPDYFRDYVLGVRRFLLKEDPATIPRAQNQLFLIYIGTMMTKILITGTICYQLVYPRSIARQSFKMLNTTTTMTMTNNRKRLPFTYNILSSIQSLFSSKIEFRTASEIAKYNTISILYFVSKEPKHVWHLITTEFSKYKIIIIIMMDQRMSESEKENGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAJ3</accession>
    <name>A0A922IAJ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAJ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="54" mass="6001" checksum="1ECEA0C1F0CE4057" modified="2023-02-22" version="1">MAQEGVVYSHFQKNSSNIGSPSIAANRKPEDEKNRTTTATTQGQGLWTFNIQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB56</accession>
    <name>A0A922IB56_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox protein unc-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SHOX2</name>
        <name evidence="12" type="ORF">DERF_002216</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the paired homeobox family. Unc-4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB56"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000057">
        <property type="entry name" value="Short stature homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="144"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9528259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="447" mass="48774" checksum="E4730815857077E0" modified="2023-02-22" version="1" fragment="single">KNGSPDPKQQSDDQNDSNDTINVQHDVKRESPSSSINETINVPDQMMIMDMKNSNSRSIHSHHTLDLIGNHHHENNFKENDRVQSPASLSLRLAAAAAAAAAAAAASQHQHQHHHHHPHHSLINGTTSSSVNHQHNNGSNKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKHESQIHKSTIMMSPHSITGSIAEQSRATINNYLMNNNAATTTNANANTVAGLSSSSPLSILQSQTSAIQTSTITPTSNTISSIGGNVHTIGSQPPLPTSFNVAHYMPYLSHPINFLQHYAALAAAASSSTSSASSSLPFASNSLFNNGNSSSSVSSASSNIHLFGSSSSSSGFGLSSRVPMTMIPATSPLLMTTKTAIKTNVDEQSESEIFTRINQTEKEHFFPKQSTSPIDNDRMTIDLDQDSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBD6</accession>
    <name>A0A922IBD6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBD6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1127" mass="130135" checksum="449C2EC38A376FC7" modified="2023-02-22" version="1">MVLTRAGTEYGDDINPEMLRNEVKDLVKRIRINNISIFHQGVKAAIKTGKVLYDEYYKYSKLIIEDGNFTSEEEKPFDEMKSMVDLAFKYAQSMDVIERNSERNDLTKFERQLTEDKCNEISRIAEQYPCIADHVINVVNRFHELNVTKNRTKTIETNPSREGATQNNQSYDTIDVTPPDATPILMPQPSTSSNDNNQPLYTIYHHQKQSTSNSESEQQQQSTSNDNQKQQQPECTVPYWWDYNQYQTNWSGGAKVAAKKLEKFNGDPLAYHTFRKTIQHYVVDNPQIRGNANKIMEIIDLLPHKDRYIIECFNPNTCTMVSIMAELDEHYASPNRIIPALVDRLRKAPFLSLRPSERDWEALVEVTILIRNTLSSANLASEERSLVGVLLQKIDRAHFMHIGDKRAITLEQILQYFKTGLDRERTAISQIASSDLNVKSTNRPSMVANRTTNNVMMTTSTNTCMFADGNHKTENCPLTIQERRQIAIDKRMCFRCGGFRHNSKDCDRRFKCDICNKNHITYLCNDLKPKSFPPTTTNEIESTNNASNDQTVPKQIAESSASNVNQSSKQSVTNNLLTQNSTSLYKTTMATINGRNVRVLFDDGSGSSFISRRLAELWKLRTDEVEPICMETLSQSTPTITGSKVVSLSIPICDGSNEHLKFRINDKINTLRFDCVNHEQQLLIRQQNIPFYDEPKMVDILIGLDNINKIQLEDEKRLSIDLVAKRTTLGWTVFGLSRNLNGVLSSCKNIGNEIGPEHNVDKESKLIMNKVMTNYCKTEDVKYDDSSKQYSIKVPFIINEKIDPNVNEIKEVMNHMLMQMNVDRRKQYRSMMNDMETKEVIEPTKIAPNISYRIPHFVISRDDEKQPWNKAIFKEIILWDIVRPLLKFCMKPIGIINGIQSVFHNIEIDKEHRDYVQFLWLNLEDNSMCYRFIRRPFRISSSPFVTIGIAVNVSDDEIMSLIYEKSNLIQRKIVIGELIALSYGAIRAKSIEGMIRPKHLILYSNVTNNVKRSERNINQFQCPVAVRLYTIKSKVTDIDLERKCYNEWLQQIDVPPDPWKRSINEEMSNRIPMLMTKIMFRIKSMNDRCRQWRTKPVSVNIDNWLSWKSPKNGGGMLKKYRSIGGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICF9</accession>
    <name>A0A922ICF9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_002443</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICF9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276980" description="Ig-like domain-containing protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="27"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="128"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="238"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9528500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="493" mass="56116" checksum="7B939893AAF48E22" modified="2023-02-22" version="1">MDTSIMESLSIISLLTILLIITGSIEAKVSIRPEPNGEVGIMSGESKYFQCIGSSNKEKLYWINPQGQEIVNDPNNGIYTVHIVKKNTIKLELKNPTKQDSGVYKCVSRNEQNQEISSAFFKLHVFNPTVVKAPKESYQVNEGDNVRIDCMVTADKDATIEFMWSFGQYDLSQDPRYRIEINRDRSPNPDEIRTISRLEIRNVSKEHDGNYVCAVDTTNRFISDSKELKLTLRVQYKPRFDEKTPSHIWVSEEAVQQGGPLSVNISCIVYADPVATIGWFTADNRPVDHNQPRGGVKTKIVDSINMSTLMLTFRNIDEIRNPRPNSRIKYKCRAENTQGADSRLFEIKIGRIPDSPMVVGLDYKDGAIILELNETNVEPPIDIYRLEISDEQAHLFNKSNAKDNTTYVIETALPRGEHKVNIYAHNPVGWSEQPYSSYFLQVVSAGYRPSSILSSQYWPCYLFILVINIISLMQLQSSIHFDHHHHHQTAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICG0</accession>
    <name>A0A922ICG0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICG0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9308" checksum="96AFEE728F187032" modified="2023-02-22" version="1" fragment="single">IACLTSFLLPKQKNKQQTKRLKGKSIKFFFFGHKPTNQPNKKPTNQIIKTLATKAVSRSDCHTIFINRIITNSSLNLSGYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ID54</accession>
    <name>A0A922ID54_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ID54"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="75" mass="8731" checksum="1343671BF83E7A78" modified="2023-02-22" version="1">MNGVSVLTKKENKVLKNKMLINDKIIPMDNEKTPSERQKNINGDEIVMEESSPNDHLKCQHEQQQQQNENDHCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDD3</accession>
    <name>A0A922IDD3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">NSD1</name>
        <name evidence="24" type="ORF">DERF_002247</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140938">
        <property type="term" value="F:histone H3 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15565">
        <property type="entry name" value="PHD2_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20144">
        <property type="entry name" value="PWWP_NSD_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05838">
        <property type="entry name" value="PWWP_NSD_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055198">
        <property type="entry name" value="NSD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055197">
        <property type="entry name" value="PHDvar_NSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22908">
        <property type="entry name" value="PHD_NSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23004">
        <property type="entry name" value="PHDvar_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
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    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
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    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
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    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="21">
        <location>
            <begin position="201"/>
            <end position="265"/>
        </location>
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    <feature type="domain" description="PHD-type" evidence="18">
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            <begin position="1"/>
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            <begin position="1"/>
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            <begin position="450"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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    <sequence length="1451" mass="166138" checksum="594BFBB6DDF723E2" modified="2023-02-22" version="1">MDSSKTNDKEQSTEIINNNLNVEQSSSSSTTTKTDMKISEDHVDSTMKDDDDNSECNDEDNLADENEQQAEEIKKEESNQDVKNTNDDDDDNDVEMADDDNNDNELITRRSLRASTTANSNNESMASTMKQEASSTTPSDKRGRKRKSLSSTDSPSSKLPKYEFIPISLEAKTIVLNDNPKYIYDRQKLISVPPKDGCISVGDLIWAKMQGYPWWPCMVTVDPCTGSHNRVSRTTFKTEYHVQYFGPEPSRGYINESNIIPFEGYQQFRDKIEDELKDLDKKKRAKSEQKYIVRGSLLKKWNESISEAEEAMDLNREDRLELLNFNYVRQSDLQISNRSQHQQRATPSSNEDVYAFDDDDAFGDSTLPTGFVFRKRLPKGDFNVYLKRHLEEEIENNSDLSKSEVIKKLKEKWSGLDEAIRSIYVERKAIYEDESNMLVSKRSNFDDDYFNDDDSDYDYNDSDSDRNGFGFNDDQSGEQFNNDQKSAMTSVKMKSRRTKSRKSEKLFDKIKNQDHSTEDLDNEEEITKNDDNDNIENNDKSSIVDNGDDTKPGPVKTMKKTPGRKSRNNKKQSDLNESQQNDSEQMKTKSLSKSNDENSTSSTNKKRKSTTQNLNISKSSTSEKKKSTTISLSKLSESNSSIEKRLCFEFDHVEEDDSTQSDTSEKPKKIKLIRRYCHHCGEEVKKDDKLVTCKGDCERMFHLKCNKYIRMIALDDGDYICDECQMGKYRCFACKNPDDLDTQKCEDKRCKKYYHLSCLEHYYPIRVNEQSNSFVCPLHSCITCHLLTLDDDEYRHSNRKLMKCILCPVAYHANEICIGAGTMQLPDSHIICQDHYEDFNTNRNNRHINVNYCMACIKVGNLICCERCPAAFHEECLEYKFDHEKNFYCQNCLVHKHIHYGEIVWVKLGQYRWWPGRIVHPNQLPDNVSNIKHSDCEFPVYFYGSHDYYWVNKGRTFLYMEDDNKLLTSNSVSKNSSKLIKSFNIAIREASEEFEKWKKDKVTKNLSQIANKPPPYQHIWTNRYVSKSHNNNNSESNYHVCDCKPENPCGDSHNCLNRISLIECDPKKCPTGEKCQNQRFRKLEYVKCKPFRTASAGWGLRTLEDVEKDRFVIEYCGEVIDEKECRRRLETKTNKNFYYLTLDRVNIIDAGPKGNLARFMNHSCDPNCVTQKWMVNGATRCGIFALKDIPAGTELTFNYNLDCYGFEQMECKCGSDNCTGFIGGSRPNGNGNGSNVNKNGKRITNGSSSSTTVVSKSKNGNGTKSTNNNNGNKSKQEMNESNDQYSKADASGDEQTLGVVHENVCFKCGENADSDDPSPIIHCNHRESNCTKTYHLKCLNKSDKSDLIGSTDADIGVGLDPNNWICPRHICMKSQLPDNSCNEPAFLFCSVCPNSLCKQHASTMTDNLQLPDNQFLCGDHRISDVEGGLIVENEFIDNDGDDVEMINGVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDI0</accession>
    <name>A0A922IDI0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DDX3X</name>
        <name evidence="13" type="ORF">DERF_003900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDI0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000397">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="258"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="459"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="630"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="680"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9530062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="706" mass="80265" checksum="9F071B78099B8162" modified="2023-02-22" version="1">MSYPQNGNSPLDQQFAALDMNQNNAPRFDATAAAPMQARGYVNSNENFQNPEMYNRRAYNNQYNDGARDSYNRPRTFNNSGDRGGNRNFNDNRYPRENGFVNRGYNNNNRFFPRSNANLAWRDLPQPQQPQMEIANGFQAENQNRNFYPRNNVNGFANNNRVSSGNFYPRGPPPQQVNQDWTNPLPRNEEYEKHLFAGVHTGINFEKYEDIPVKVTGECCPQPIESFDDSQLKLTPIIENNVKLANYDKPTPVQKYAIPIIMAGRDLMACAQTGSGKTAAFLLPILNNAFISGPPAPPPVRRPGGFRARHFPLILILAPTRELALQIYDEAKKFSYRSRVRPCVVYGGSDIGAQMRDLDNGCQLLVATPGRLIDMVERRKVSLEKIAHLVLDEADRMLDMGFEPQIRQIVEQCDMPETGVRQTLMFSATFPKKVQELATNFLENYIFLTVGRVGSTSENITQKIEWVNENDKRSYLLDLLNNDVHRSGPDSLTLIFVETKKGVDYLEHFLERNGCHVSSIHGDRNQNDREDALYSFRAGRTPIMVATAVAARGLDIPNVKHVINFDLPNDIEEYVHRIGRTGRVGNLGLATSFFNDKNKNIAVNLYELMVESKQTIPDFLTNMVKSINAESRSSWNRHKPGPRRYGAGSFMSRDFRQSYDDHGESPRYSMAPPRQMNGFVSYNNSNHNNSYSRPSNPRNNVPSCWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDJ5</accession>
    <name>A0A922IDJ5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Transmembrane receptor protein tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MST1R</name>
        <name evidence="16" type="ORF">DERF_002334</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDJ5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037518164" evidence="14">
        <location>
            <begin position="19"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="277"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9528381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="612" mass="72344" checksum="8A58F026C431996D" modified="2023-02-22" version="1">MLIQLYVLVKFMFMTVFATTNDSSQSSNEFWSIINHPCFDQKNAHDCQQWNYMNNSEQCMWCEYWCIHQLNASHDCEHYSYRLNYLFEKPKIMTIKPRAVFSDVPMMITISGQYLAQSDKFSSVYNDIDNIMFTSHNKTIDSPYHCKIDRKTFESIRCIIEHIDHTAKEIKLHLEYTKTVFQIKRSGIKFETNISLSVLPHHNFDSIDSTNIDSIAYEFKIVISIIGGMMLISSCWFLYSRRFYFQHHYEILKLKFYLQKMQQYLRQKNLYLEYESVEFKRKLGEGKFGEVYLARLTTIDQQQQKQQKNVAIKRLRKESSYFRMKMFITEGIQMSQYKHDRILIPLAIFIDRTNNMPSIVMPLMINGNLCHFLQQRQLLPITELLKFSLQISDGMRYLSSKNFIHGDLAARNCLLDENFDIKIGDFGFSRQLYKKDYHIIDGTYRPIRWMSIECLQSKKSKFTKKSDIWSFGVVLWEIFTLGSYPYENLSDNDLCRDIMNGYRLPPPSSCPDVIYAVMIKCWSEDSTKRPNFECLCQEISQILAAIKRQQQVDEMENASVAGTDDQQPITVICKYNNYTSLAQRFIRPNNHLNNDDEDEDFFECSIDVDDNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDZ0</accession>
    <name>A0A922IDZ0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDZ0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="54" mass="6229" checksum="0C0D41156A4BD8F2" modified="2023-02-22" version="1">MITTTNITVDGDGVDDEKDIKAKKKCDGSLLFDDPRLHIQSLMVAWYWYPILEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE99</accession>
    <name>A0A922IE99_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE99"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="80" mass="9178" checksum="B193498B49C5DE56" modified="2023-02-22" version="1">MNPDIFVVVLFLCTKKELRMKNKIFLSGPLDLSLVSTFLLKIFGNYFLPLLSLLLPVRMCKQLALPSDQKKTHNFHCKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFF6</accession>
    <name>A0A922IFF6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RCC1 and BTB domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RCBTB1_3</name>
        <name evidence="5" type="ORF">DERF_004143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFF6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="145"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="194"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="248"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="365"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="584"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="632"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="686"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="809"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9530330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="970" mass="111086" checksum="537E4C87425ED9DD" modified="2023-02-22" version="1">MARLPNENIDIELFKDDFKNIDQEFLPSVVSIFRLFPFIDNGKEFLLMTKEATYAYGKLICSWLSLELDMTRPQRISCLDDMKIVQVDSGWNFIAILTDDGRVYLVSNNSNFKTNNTFRLINTGNNRFKMIACGWFHLLLLRQDGQVFAMGDNNCGQITGNKSSYRRMIHIKNLENVKLITCGGDHCLAVTDTEKVYSWGRNGCGQLGVGDVENRNTPCLVSLPSADTTRIKDIVAGDRHSLFLFENGQLWVCGSNDNGELGLGDKNNRSNLTKIPIENVQQIACSKFHNFSLAHEGSSYYAWGKNGNWSSPVKLDDSHSSFASASVQVLNSPHTFGLTSTIYAFGSNDSIYKSILLLFDNQDSYDVEFIIGKKRIKAWKCYLKSASKYYAGMFSGHWSENDQVIINYYSYETYYAYLRMLHTDFGFLFVCSCLLRSNLSIMHKSRDDVIEIELFKDVFKSIDQEFFDSIILIASLFNDNGEFLLITNDYNVYVYGTKICSYLSFEHDQERPQKVAILNGFEIVQVDSGENFVALLNHDGQVYLASNDLNWKTNETFRLISNDDNHFEMIACGAKYLLLLRQDGMVFKLGDNEYVQSTCGLLSYETMIYIGLENVKQISCGRFHSIALTNTGEIYSWGRNEYGQLGVGDKNERITPTIVKFDTTIDNQIKNIATGENHSLFLVENGQLWGCGSNCDGQLGLGIDKKDIRVNKPIEKPIKIPIEKVKKMACSKFHNFSLAYDGTSYFGCGQIRNKSFWRSPCKLESKSFSAASVNMISFPITFGLTTTIYELEPHYSISTIRLFNNPDNFDVEFIIKGKRIKACKCYLKMESDYYRRMFSGAWKENIEVEIKDYCYNTYYIYLRMLHSGSIRINQQNITELIDLANCYCDGRLMQYCRTFIQNDLNKRTMSTYLSLIIKYELKEMHAKLGQLAIDEVLPKITDNILQNGDDSITKFLDWFFNQQSFLKNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFI0</accession>
    <name>A0A922IFI0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFI0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="122" mass="14172" checksum="0B5C6BDF1CE38FF2" modified="2023-02-22" version="1">MFSDIIETREDVYLLDGCVDDGCLSTLTKNFRLVSKCFEPLHETLSTDDEDYSIKLCCNIVKYERCLFPYIIFLCGMDSLDKFEAELRSVNSLCSLTTLQWNKCEVNKTLTMEENEVELREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KRC3</accession>
    <name>A0A922KRC3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_016701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000010">
        <property type="protein sequence ID" value="KAH9490502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KRC3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9490502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="321" mass="34538" checksum="0BE3CAF76DADDB4E" modified="2023-02-22" version="1">MRSVKSLFSQLSCGSHRSVKIDSPNSGSDKTNLSANHNIENSQEISGNHSSLPLMQVTTEKMSNRNRDFSEKVVLITGSSGGIGLATAKYFARCGAKVVINGRNPVAIAKAAEECQCISPKKYRALQMKADVTKEDDCKRLIATTIDQFGKLDILINNAGAGAFGSIYDPKLLETLEHMINLNVKSIAMVTQMAVPHLEKTNGVIVNISSTLSFKPNVHFMPYCVAKSAVDMFTKCIAMELGPKGIRVNTVNPTAVRTNFQAATGAGEILDGVLKHLEQTNPLRRIGTTEDIVNAIAYLTSSESSFVTGHSLVVDGGSVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KU40</accession>
    <name>A0A922KU40_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KU40"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="8423" checksum="D4D966A5DB3C82DD" modified="2023-02-22" version="1">MVSSSLFFQQEKKQQDLWSICGDVLQSVMMNCFLFMYRLRLLCFISNSLNGSLLWPMLIYQWHKKKILNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVB9</accession>
    <name>A0A922KVB9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVB9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="116" mass="14261" checksum="B4471B4B9C84A7FB" modified="2023-02-22" version="1">MKISKTDRIFNTTKKNYISENTTIDRKTINELIKIDRLIDFIDDNDKTFLIFHLVIDFRINRIDFFLVEIIMLYEEFLCFHCRFDLTVNKNDDNRQTRKKNISTKHKRIKFSIFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KWG0</accession>
    <name>A0A922KWG0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 17">Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="17">GNT-I</shortName>
            <shortName evidence="17">GlcNAc-T I</shortName>
            <ecNumber evidence="14 17">2.4.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MGAT1_3</name>
        <name evidence="19" type="ORF">DERF_013466</name>
        <name evidence="18" type="ORF">HUG17_1145</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 17">Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11456"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="Rhea" id="RHEA-COMP:14368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60625"/>
            <dbReference type="EC" id="2.4.1.101"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="17">The cofactor is mostly bound to the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Golgi apparatus membrane</location>
            <topology evidence="1 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.101" evidence="14 17"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KWG0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003827">
        <property type="term" value="F:alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000252">
        <property type="entry name" value="Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.20">
        <property type="entry name" value="N-Acetylglucosaminyltransferase I, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052261">
        <property type="entry name" value="Glycosyltransferase_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468:SF0">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10468">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1/ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 2-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7645607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9497474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="438" mass="52512" checksum="8D7AF5697331A360" modified="2023-02-22" version="1">MARLRKYFFFLIISVPFYLFYQSGYLKKSSRPLSNMMMMNEKFKKNKIFNQTENNNNKDVDDNNKVNTNICVLLIVCDRLSLIQSTLNQLKSIRNKTIVSFRKRNVGHDILQMMINMPIVVSQDCNKKSVYKMIEKFVNDSIVQKHYYFPFHNEHIDTKLKRFQGYVKISRHYRWAIEKTFQTYPMIDKLIIIEDDLNFSPDFFEYFLTMSTLLDNDDSIFCISAWNDNGKDHLIDQSSTSLLYLTDFFPGLGWMLKRSLWYEIKDRWPIAFWDDWLRQPEQRKNRLCVRPEVPRTSTSGMKGVSRGQYFKQHLSFIHHSKGYYSFYENRKIILDQLYSKNYDQKFLYQVYNKSQDIHPIALKTMDPIYVHGTNSTYRITYFTKNEFIDYSSMFGLMNDFKCGVPRTAYKGIISFMYNGMRIYLAPPVTRKIYLIDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYN0</accession>
    <name>A0A922KYN0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYN0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8854" checksum="5B3C9FEDCE4CB115" modified="2023-02-22" version="1">MFSIIFRYNFPDIENDKLIDSNNVRVSRHIHQCKENLLFYLSKWMDHSSVDIVNLDYHHWIDHHHSYDNHCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZQ3</accession>
    <name>A0A922KZQ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC protein, sub ABCG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">wht-4_24</name>
        <name evidence="12" type="ORF">DERF_012087</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZQ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF78">
        <property type="entry name" value="ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="722"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="793"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="840"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="872"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="933"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1027"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="282"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9501226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1057" mass="118585" checksum="A2FD1E8C6E34853F" modified="2023-02-22" version="1">MSSLSSSSQSLKSKRDMFLFGTSNNNNNITSSSDVNGLGPSSSSSSSPISTTTTTPPPQPPQLSSLSQVTIMKSSNDGGSGNSVGDGESSSGVGSIRSSSSPPSSSSSSSSSQQQKQQPSPQPPRYLETFPNVNHLNQSHQQHRRYLDQTIDTNHNHHHDDENQSLIDKYEKPKIVESSSRQNGQLYSSPPPPPPPPSLPQLPLSSSSSNNWHFEKNNNNVMLTNMESIAKNKLQMNNNGDSIINRSNQHRQQQQQLQQQQQSTKDGVELIWRNLSYHVSRFQWKTFIKKKGRGNTHKRLLNTISGSMRAGELMAIMGPSGAGKTTMIECISGRRRRGVTGDIVVANCTKRTKLAYMAQDDAFMPCLTVYETLLFASKLRNYQRNNRCKVKLIDDNENVYNATTYPDSNLVIRSVDSYEKNAINIATTTTTTTASVIDNDNNALFDDETGCCGRAGGFACLPDGTYHRNLVNQIINKLGLDQCRNVKAENCSGGQQKRLCIALELIHSPTILILDEPTSGLDSVSCLQCVSLLRELAHNTEQPMAIAASIHQPTARILQNFDRLYVLAYNGQFATGDYGHEVIKQLVNDQTTQHQKGCLMIKYSNTISSTKNKHLTSMDSNHQTSKDSTIITVVNDGNNSNIDDNNIETTTITTTTMMMNDNDGTLISDEVRLWPENWNADTVSINKICQRSRKQIKRREFYKTMLLWMRCMLLSFRDPTEYLLRIFATVSIILLNIVLYNDSKMGQADGCSQDTIMHMVNTIRSDYDGNQSFSLANSFLEGPGAMAILNFGYIFFAMTFCSFLSMMPTILTFPLEVGVFYKEYFNGWYSFSSYFLAKNFTNLLPALILPILYGSTTYLITNQYWETWRFLYFIALLIMISLVADGLGLTISAIFVHNVNAASIFAATSQIPLLLFTGFLVQIDQLPRIIQPLTYLSYYRLFFESTVITFYGFNRCPEPEPFDLKRIRSIMGDDAEEMMDCVWQNTNFFDSSSGPSLTDRLERILSASENQNPSLILQNFHLHEKDLPFLMCLLGSYAIITRVLAYIVLYRKANSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZW2</accession>
    <name>A0A922KZW2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZW2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="121" mass="14485" checksum="AE057D7B98E2FD0C" modified="2023-02-22" version="1">MNGTMSPMQQRDFHNDKKKEFSDSEFLNENRGCFHHHHFVWVDDSLLTRFRRSSSSSSKVKKTKRKVMYSWLLGILKRNETRPTNGKKQSNFNNKSKNDTDESIFLVVRSEHQHQQQRQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0Q1</accession>
    <name>A0A922L0Q1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0Q1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="8438" checksum="42D3DFA5AB02BAC0" modified="2023-02-22" version="1">MKNLLLLSNNNNNNQKTYMIDDCHNDLHEDFNYCQFICMKQQQQQQQESITLIASVAAIATATANGSNIWFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0S8</accession>
    <name>A0A922L0S8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA topoisomerase 2</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA topoisomerase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TOP2B_32</name>
        <name evidence="14" type="ORF">DERF_015946</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0S8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="13">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9491215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="202" mass="24093" checksum="3DA9DBEC4EDE40EC" modified="2023-02-22" version="1">MRSTTKKKFKMMIPWYDEFTGTIKRLDKQLFMIYGEAAILDEETFEITELPIGVSTQSYKKTILEPMLKNNPPYIKNFKEYHTNASVKFVITMSKENLQQSLNNGIHKTFKIQRSMSTTTMMLFDYNGNLKKDIKTAEEILTEYYPIRLKYYKKRIEYYNEFFKVELKKLNNQLRFISDNDNIPNINKTCKKDLIAILVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L196</accession>
    <name>A0A922L196_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DFP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L196"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="20231" checksum="BA4148A51A77D310" modified="2023-02-22" version="1">MIVCSMAGGYGGGGSSSYGGGMSSRGSSYGGGGGGGGYGGGGGFGAGGMGVIQAAIQSRHNVQFYDVPSSGMINPTTIEVGAQAIPVNMIFRSASSNLNVQQMHQGAAGSQQESQSEDEPHILRHTVKKPIYQMVNEIITPYRKITQEVKPVQEDIQTIIARMSGGGYGGGGAGGMSGGGYGGGMSLGGGGGYGGSSGGGRKGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1J0</accession>
    <name>A0A922L1J0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1J0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="101" mass="11882" checksum="8947C3B26A709AAB" modified="2023-02-22" version="1">MMMILYAQIEVQNILLQPFINWMPNILFINLQILIIYNHHVDYHIKLDLNPASHEFIYLFGNIVINLISDCDCVLLVVDWLVGWLQPGNQNQMAMRVLMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1S2</accession>
    <name>A0A922L1S2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Secreted beta-glucosidase sim1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SIM1</name>
        <name evidence="8" type="ORF">DERF_010197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1S2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000007">
        <property type="entry name" value="single-minded homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF36">
        <property type="entry name" value="PROTEIN SINGLE-MINDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23171">
        <property type="entry name" value="bHLH_HIF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9511764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8023" checksum="DA8EE80CB9018860" modified="2023-02-22" version="1">MKEKSKNAARSRREKENAEFLELAKLLPLPAAITSQLDKASIIRLTTSYLKMRAVFPDGQGRSFIHSFIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1Z7</accession>
    <name>A0A922L1Z7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1Z7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6870" checksum="A6635526FA1697C4" modified="2023-02-22" version="1" fragment="single">TQQSGSKKIKKNSQLKKHIESPLAPINKAIVVDVDVCMYFIYILHNDDDNGNKRKRNMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L229</accession>
    <name>A0A922L229_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_013179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L229"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037389597" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30693" checksum="4E032DC83AED2A4B" modified="2023-02-22" version="1">MATSFGRHFIWIIWTGWIYNIQCRTIKTSITKFSFIYAVSGRAKIESLDCLNRFLRRPDRCDRLPAVRLRSSDLLYDPLDMHRMDVSSMISYLQRFFSSFVIIVVRATTLGNLILLLPSTTVFASPLMIIKFLYASRLLVDQYPCPPVLKLVFGLFRIVLRLVAERNNGVLPECLPRLDVVDVDDHNHHFRSLMVVAVVDVDVLQDSSLEQTILLNDESVSLKPVIGGKNPVVTVVGSFVGTLVVVIGSSSVIVLTIRVVDTTRTGIIYCGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L512</accession>
    <name>A0A922L512_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L512"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9512035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="50821" checksum="02B2356D043ACCE8" modified="2023-02-22" version="1">MDDKKKQRANLRNKVTKKHGDAVLNLLDKDETTKTEIINLIKDLNAVETELLEIDFDEEKFESYNRKCQVLINYFSVTTTSNTERAIKYQRRALPTFNGDIIQFNLFFREFLRIVDGDPALRIDEKFFTLKSMLKDEPLRLVANLLETEDNYERAKDILKERYQDKRRISDIIINRIKMLPTINVNDLDGMQKIVDEMACLHREAVDHGLDSYVIEEVIRPTILSKWYSPEAARHGSTCSGLIEFLVQDVKIYMRNRDIMTTNQVNVSTRANCVFCRRNHKSIYCNDNMTNKDRKDIAVRKKLCFVCLQGNHQSDQCKSNYSCKKCGRRHSLVICTDSTTKSAENVVAQTIPKKRAWRPNGLIYFNCLVNNKPIRAFIDTGAEITCISKNLFDQLKLQIIKNSIINIRQLDNLTQSLGRVKINLQIGRITRCVEAHVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L514</accession>
    <name>A0A922L514_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DERF_004331</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Derf</strain>
            <tissue evidence="21">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Derf</strain>
            <tissue evidence="21">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF527">
        <property type="entry name" value="PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2186"/>
            <end position="2207"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="100"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="221"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="644"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1181"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="20">
        <location>
            <begin position="1902"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="2275"/>
            <end position="2553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2625"/>
            <end position="2646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="2625"/>
            <end position="2644"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="2304"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAH9520631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2823" mass="325345" checksum="44C785723A98503B" modified="2023-02-22" version="1" fragment="single">CKNGCHYWHLSPSACFQVCRGGGGGGGGGSSGGGVDYYNENKNRWQVSQQLQQQQRQQSSIMIENGFGDQDNYCALGCNHAHTVYIDHIKLLLETNGSLRPPRLVMNSLTNDSLRIEWNSLQESIRSQVNISYRVQWKYQNLPSQWMYIGVAGIRSFIDNTGSNNNHNGDRTNILHINGLNAYTSYLFRIEWIIASSLHGSIVSESSEPFTTLPYGVPKSACIIVSCMAISSNQISINWRAPAFPNGPIIAYSLYLYNENNGHRTVKDIHTHWDPFRTSNLAIHSYVFNDLQSGTNYTISIVTHNNFGEGIRCWRQISTPEHQSNKNNNDDGVDDELDMNENMHYKLYLASTKSVARRNVDFLLDEEILYHLTDYVENGDITGMAVHVNRRYLFVADSSGTIRRIWLKENSINQVLRIINGSNQPSHLSIDWLNDRLYWLEEPANRVMRSNLDGENVESIYISSFQPNQKPIDFKVDPYNGYLFWIQSNMFNRTAIYRLDLYHLNGSIRSGSSNSNALRSKIELIYQSDSWISTFAINYLNYRLLFPMTHTASIHSLTIDGNDETTIRDNAVIAGANRMDISPFAGMDNMVIYNQRLYFSRAENITWEEYHMDEQMYYHNTYTTESQLISLAIMDQQSQPIPVPLTPVEAVEAVFLDTSARISWQKPALFGTSGRGAWQQWRYEVAIQESDNPQVVHTAKVNNITQCDAVELQPDTGYEIRVRAFTSAGNGAWSNKFVGRTLPSMESMTNRPYALIATKDRLLIRTELDGKFKQQLLPKSKLDTLGVNNITGVHVYKDSVVLNTDQHILHYGSLTVEHSSLNVVVNKSNAHSIAVEWMAPKIYWSNPLERMICRCNMDGSQIEILPIISYAQELAIDSINGFLYWSTSSSLRIARLNGMKNSQRLLLRTQQIKSFSIDQKNGKLYWTTVRSLDSAETVESDENILDQDENIVMVLNQIDLFETLDQIHEIDSDSNRIHSIRLARRQSNNLIGPISSFARRFWWLNIEQNRMVVSDDHGQTFATIRQINGEISTFQIVTENDHHHQDRRYEIVVVPKPVDENSIKIQGTWENFTIKWDPVTNINYGQVFYDLSLENDNVKVISKQSKTADNNLNHFILNQTEFILPEHLKPSKPYAKIRIALRSFTYWASSRQVVVTLHTPSSIPSKPRSVRVFTYVMNDSDKLNPKRTKQEKRFAAEARWLEPENPNGLIQSYTISLWTMDTRNVTKVTSIINKVISNQLWYRLEDLKSNATYYFEVRATTDVGEGPPSQVIQFKTYRSEPPMRLLLAERDSIYEADMDLKQIIRSVIKSLSPSLMDYNFAENRLYFVEDGNFLKCSKLINGNDNVDDDDDDDDDEIVRPLRSSNQVQSGQSGNYTILAHFSQSITSITMDWLGRRLYISTVDFFRNHTTIWCYVEETQSTRVVLTITGYHINTMRIDPYRSMLIWTQQPIASKISGRLNHESTSYMITAHRCRLAINGSVCDEQLNYFQSPSRDRLCNCTHRPNISGAFQLIHSLDQSTMNGQRMIYFDRNGQTFVESIDGCYCRRITSFVETTNSPVAIELDPILSKLYWKNDSFNGFIYSTELDLEHDSDFRQPIKMINMAKPIRNMIQLSRQPYPYSLECLIPPSNIHLDMRMLKHTSTSLTLQIDLDRMTSNDIRSSNNCPSPIMSNHHESIDWQPSLASIRFRIRYGINCTDQCTTIDTFNQTITIDNLEPFSNYSFTVEMDNFYLELIRNRSQHQLELAYNASLIIPPILKRIDYSDSIYRPYLYWDGFIFTTSESRPAPARNVHAIVESPERILVIWDRPERLNAKQVVYEVRCHSHNDSFDLQSWRLDDKLGGHHQFSNGSYWIHMDKIKPDTIYNITVRVYAVEKNKQSKDFYVDNHQFQDSVPITIRSFSSPSELQLKYLSARQIDLEWQAPSGESVIESHEIWYNSESDIDENKHIDQHLNDEKINWTKFASDHTQPEQKYQYQFKNLKPYQWYKFRLELIYRPSRLRYEWPRPSKIFHIRTNMTVPDGPENLEIQNVHSKNKDSKEIVETTNNNGMNIYKMIWKSVRSNSNSPVYYQLYRWQISSQDNNNLIDHRINSSLQNQIVTNQPQQQQQQHSWTLVYNGTDNYWIISGLQTGQQYHFRLYASNQLGVNQREWAQTIRPFWLGQPADIDGDINSLITYQTSFGHGESHLFIIMFAIFCAIAVCLVIFSVCSLRFYKLNTKDVDSNNQSIISSSTNSHQIELIPWQQRPHPHLPNALYVNSSVQDIDLTDIEVFDYQTITLIKSLGKGAFGEVHEAILHKTEQRVAVKVLNKNSTKDEDQCNFLKEAKFMSKFKHPHILQLLGVCLNHHSSSIVIVLELMEAGDLLKYLRSNRPGSNNHSNKQPSTSISSSPLTIDDLMSICIDVAKGCEYLEQKQFVHRDLAARNCLVSSADREKRVVKIADFGLTRGLYQQNYYRKEGGLMPVRWMSPESLSDGVFTTQSDVWSYSVIMYEVMTLGQQPYQAYSNKEVLEFVKSGGILERPSFCSPQMYSLMKQCWNYEKELRPSFAMILKHLQQLRQTLRIEFEQLIQQQQHAMKQRNRLTTVHNQNYQPIIDSIIIPNSGINPFHHHQLDLAAYCNGHVGLKQQQQQQQQHPIIHQPSSSSSSSIERTDPLLYSTIGATTTSTGYIATTSNTTLTTLDDHNSMIDDLIPISTSSSTMTTITANNNDGLTRILSMSPTLVLDPLPQTAKQLAHLSNNNFHIRSTSDNYPNINKPIIMANHSNHNHHHHYHHERIPSIPLTGTTASTIYLKMAKESNNKNQNSFQMFNELMDQHVDLDGYQLPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L620</accession>
    <name>A0A922L620_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_004918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L620"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="50"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="207"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9521244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="288" mass="33039" checksum="9DEA0D5329864CA0" modified="2023-02-22" version="1">MAMEKHVMVNQLKMAATTTTAANNNNKTTVANENCYVTQTPGTILESLPYYYGCITREDAEWILYDEGCPDGMYLLRESGNDFVLSLCHHNSVLHYRINKLSNGNVVLQGLPNQTFQSPMELIETVDGLACKPTRPLRAPFGKCLPPIHWKMNVETIREQLLQRAPNWGLTIDEMRENIDCDLHFSPTFSPLIRSLIIKSMHELQPWYHFRLSRLEAEKRIESSGHLDGKFLVRERDESSYAICLSHDSRVKHYRIDILPSGNFAIQDGPKFESLIAVSDFFLSIFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L625</accession>
    <name>A0A922L625_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L625"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="327" mass="39202" checksum="326B96A831F9B3E1" modified="2023-02-22" version="1">MTSDKISNKNDRKIIVEEEWQKLVQSINQPADYNEINKRYDRCSKLINEHLHLRDELKKTFDDNIQTVLRESNLEFNDDDPIPTLPQLIQNQKQTFDRYQQSKQTLNDITHEQLKSEEQLKSLQTEIETLRKKRDQLKQTIDEIVNNIRVKSKNIYLQTHNNELIACLFNHNDGHLQDCLIENKENSTKEDFWRDLKQDLKFMYGCPFKKLYECDDYYYTLKTKFNNDYKANEKTELVISVLERIMLAEGNLSMIYEPRVLPSFGLHICTRRPCDCYVQNCFTYCAWNWCHVQPLNDEDDSWIYIPCITDYNLDSCLNLEWPCQKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7I4</accession>
    <name>A0A922L7I4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7I4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="132" mass="15659" checksum="F5A6C7622FBAA9B2" modified="2023-02-22" version="1">MEQLQLLSSLSISDIKKFDGTNFKFWLDEIKLWCDGCGFSDLLEITSIKNVNADKKKKLKMLRARILCFIREDIREAFLEYDLPSEIIDQLKNRFDKQNHICVCMRQHHQYFDLKFDCFNSTVLTLIESILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8C6</accession>
    <name>A0A922L8C6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8C6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7217" checksum="439155635AFBF722" modified="2023-02-22" version="1">MIAPTPPPPIIFVEGRFQITSKILSSPSSSTTITTLLIVSFATEMNMNISKIKRSTETTYVTILVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8V6</accession>
    <name>A0A922L8V6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_008141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8V6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9517467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="652" mass="72737" checksum="ECF6619D13771DC6" modified="2023-02-22" version="1">MLPATASMTVMLLTVAYYALRRQTDHNYFVNVPIPVNGSYFDFIIVGGGTAGCILAHRLSTRLNASILMLEAGGPQSVITDMIGNTQYLIGGEFDWNYHVQQQHYAGLAYPNFTISRGKVLGGTSTTQWGIYNRGNPNDYDNWSQRYGLTNMTWDMVLPFFLAYENNTDSSLRFNGYHRSGGLVSVSTETEPDPVLLNFRTLMNTLGFSTIDLNGGTQNGTAIAQMFYNADTGIKSTTANSYIESINQTARITITTRAFVERILFTNNTHASGVVFTRNGTEYHMFANNEVILTAGPINTPQVLMLSGIGPRIHLQELNIPVVRNLPVGNNLHDQVFVPLYYRVNNETLRQVDPYPRFDVANLYGYFHNASGPLAHHADGVTYYSSSQNSNATSWPDTMIISVVEFFNNLNATVSQYASNTEQWRRYWTPYANDGYYLAIDPVLARPTSRGTVRLNATDPRSAPLIDPNYLSNQTDFEALLDVTMFVVRALQRYPLPGVMQFPPIPGCPIVGCLTETLCEMYLRCHIRQLARSYYNFAGTARMGLANDTAAVVDPQFRVIGFDNLRVVDASIETPSNGDMASIMVNIPNSRYCSSDAISLDNLALIETDTRLVSEPNKYERQNAVTLMIVPLMKFCAIIDNSPMTRMDESDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9Q1</accession>
    <name>A0A922L9Q1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger MYND domain-containing protein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ZMYND19</name>
        <name evidence="7" type="ORF">DERF_002503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9Q1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.75.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032978">
        <property type="entry name" value="ZMYND19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46831">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46831:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13392">
        <property type="entry name" value="HNH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="347"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="234"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9528566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="434" mass="49816" checksum="CB8E7214BED298F7" modified="2023-02-22" version="1">MKDPLLRDCRYLNPSSSSSSSLINYNNGMTRSTISTSESGQELWPIGVKLGIVRLGYSAGKLKYTLVDEQDIVLAREYTFEARLEVLNHGNSNNSNNVSGGGAVVFAYAYQTNHHSTSIINDDNRQMILLQDLIWRRHYGPIPDNKRVVHRNHISMDNRLDNLCLLDLGSNDDNVTTHVWYTMANQVHHHNHHHHHSHSHQNQQQVVIHHNSNNQRSTTRGHHYHHHHHHHDINNNQVDGQQQQQVMPVVENQPASSSQQQQQHFQPPKSSSNDLHLTLYWAAIQQLPPEHLQQQQSTSNNNFDSQAEVNSASRCFDFRGNSLNDQESSSESSISYFECHYGPCVRIERCPREFSICGRCQETRYCGTTCQQLDWPYHKRYCRYKARRQLLAPYSYRSSSSSSSTSNSSSTMTTNTTITSPLSSSYSPRQRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9S8</accession>
    <name>A0A922L9S8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Myelin regulatory factor-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_002579</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10144">
        <property type="entry name" value="Peptidase_S74_CIMCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051577">
        <property type="entry name" value="MRF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025719">
        <property type="entry name" value="MYRF_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026932">
        <property type="entry name" value="MYRF_ICA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030392">
        <property type="entry name" value="S74_ICA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13029:SF18">
        <property type="entry name" value="MYELIN REGULATORY FACTOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13888">
        <property type="entry name" value="MRF_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13887">
        <property type="entry name" value="MYRF_ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13884">
        <property type="entry name" value="Peptidase_S74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51688">
        <property type="entry name" value="ICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="941"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="NDT80" evidence="10">
        <location>
            <begin position="417"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S74" evidence="11">
        <location>
            <begin position="764"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="7">
        <location>
            <begin position="417"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="392"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="908"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="988"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1147"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1147"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1157"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1178"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1228"/>
            <end position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9528656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1412" mass="159936" checksum="8BF342273DD30155" modified="2023-02-22" version="1">MNQKQKKNSRPRRVAEDDFGDTITTTTTTTATTVDNVVGDDDDVDNGIDNAGLDFSQLEEYINQVDDHHHNHQQNENNLYYQDQSNVLITSSTSSSSECTTSSPPPNILQQQQQQQQYHHLQQQSYETIVNNNCNNSNSIVTLPDSPPDSGSEPPFSPKSNGERMIITQETSTTNDNNSQQQDNNMENSMKHFINNDYSNHHHLNNNHHHQHNNNIKLETTSLNHHIPQPPQQQHHQQHSFHNHHGPPPPPHHHVQHHEPIIPANHHHHHSIHHQPPIPQPTIPSSNTTTNTQLSVLESHQMVTLGVATGTVVPSLTGPLTVNSVSMIHHNLSSLTTTGGGNNQSTTMIPTTNHHQNNNIYGNQHNPQSTPMIIDPNNGYLSRIAITPPDCHHHHHYTTLTTPHQQQQQIHSTPPPPTQSNNSVTPITVSMGNNNNSSGKKRKMSESKNNNTNTTNIYIKQEPNGLSPDSAAVSHPNGSNDNGNGSGSHNSNNVHSTQQCESTDDFYGDYGPDSQMYSDSFYQCIRFTPFNTNLSCPLYDLNFKEIPTISYRVDADKGFNFSNADDAFVCQKKNHFQVTVHIQIVADPFYVKTLSATDVFQKIDNFYLHFYGVKVESPTQTIKVEQSQSDRSKKAFHPVRIELSCDHVTKMTVGRLHFSETTSNNMRKKGKPNPDQRYFYLVVSLCAHVGDQIYQIAAQASERIIVRASNPGQFENDVELVWQKGVLPETIFHTGRVGINTDRPDESLVVFGNAKVTGSIMQPSDKRAKTNIKEVDTREQLKNVSNMRIVRYQFKPSFAKEVGIDHNELEGTGVLAQEVQKILPEAVKETGDIVLSDGETIENFLVVNKDRIFIENLGAVKELCKVTDNLETRIDELERMNTKLSKFNRFDSIKSSASGSTITCVSNNYRNNNNSHRQSHRHHKSCSNSTQQVPSGCNNRFFQTLIMILIFIMAFCLASIATLYILEYHRRHHSSSATSIHQTTLLSSSNDHHNNYHSQSSQPSFDLKHSPYLNVNNNHHHQQQQQQQYSNNPNSLINDNKQYDDDNRLDRNQQHPRPTAIPVLKPQVVGAPNGCYDYLSSSSLCPIHCCNDENYHVYQLNSNIDLVNNNNNDLKDTNKSHFIDHHHKFQINDPAEESSLMNETILDNNSLNGTTMTNSSDSESTITINSSSNPNHSKFNPTESNSSNNKKKRTDKRMSFGDGKYSSHSSSSSSIQDIHNLNDFHDSKFRRKRRKRRETGKSSITQNNMYSAYPKKDLARMVEMIKLLELNATIDYSYCTKLQCTQGFGNRFHYIIPISKYMELEYVTLQFGLNQEMKVDHCEMKEKPVSCSSGYYGVENLPQSYKKAADHILLPESNPHWRLPIGIYQRSSYMFRILARDVIADSPCNLPESQAGSSFVEYKFEFIRKCDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9T2</accession>
    <name>A0A922L9T2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Disks large-associated protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DLGAP5</name>
        <name evidence="4" type="ORF">DERF_002592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9T2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF1">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9528671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="384" mass="43546" checksum="D5FB59BFFEF6426F" modified="2023-02-22" version="1">MTDVAYYRQILKDQTELLDSNIEKYLKILDEELDRLPESVVGQIRLVIGQSRLFINERFKQFSGLVDDCELKRGEKEIKVEDLAGFWDMINYQIDDLKSKYAELEQLQSNDWQPIDEKKPVVKKITKNQTPTIRKPLQTVINNGGANDGGNRTTTTTTNGFANKSNKMNGHNNHHHNGKDSIDGGSSNAQVMKKAPIKSNFREFLKAKKQEKLNTKTMNSNDNKLNNENGHHENNATTSKNHNDEDIQIMILVNHNNNNNNHHDHDDEDDVKKNGHVTNNVKSDDDDNNDECSTTTTTENNIVINGDDNGNDNTKSDESNESSSSESKENRNSIQVSSIIIIFIVHFVVILEFFSPLLIDSQHSWHVSSFLLLLLLCSLIISSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9V3</accession>
    <name>A0A922L9V3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9V3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="187" mass="21649" checksum="E9543A065F2E954D" modified="2023-02-22" version="1">MVPVANFMENIFNPFVQEMEKFESDVIVLIDGTKTHVTLSKVVCDNLAQYEILGLPLSFGKSSTCRECLEKYENYPTTRCHSIINSSGTNIEKFGHHYNYREPKSCLVTKLNGIFFLSCFTSKINHGQIFNILVKDRDALQAMVVDMRNERHSINRLKHFIPKIYKYLRFDLRESTIIHEITDGAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA27</accession>
    <name>A0A922LA27_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA27"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="163" mass="19015" checksum="7E9BA17576BFCF11" modified="2023-02-22" version="1">MDQSNASTAMGTSLIETFVCNNVQKYDGTNIKTWISTIQAAFQTSDVLHFLKCDINPDLKEYVDFQHFFGLQKFTFLSNTKERVNHYESVQQIWSNLACSDKDSYSTTVRKYIVPINTSNVCDQLRTWMEYVRLADLLTTCLNLKFYYKYWTNRGRCCSNVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA87</accession>
    <name>A0A922LA87_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA87"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="165" mass="19028" checksum="45BA03CD85F2F32B" modified="2023-02-22" version="1">MNGHIFYIFPIVIVIGVLLTLDMAIGQPNRNQIENFANLAEKISDRQHTKYCERFGNLLSEKSEIIWPQVNSRCIERMVRDGAELPSNFPKIDADMRKKIVTIFERCGPIVHNPCIPQEWVAIKHCIRDQAFNTKLLELNGTAPFAKECTINQSWFGNCSSRMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB64</accession>
    <name>A0A922LB64_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysosome-associated membrane glycoprotein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Lysosome-associated membrane protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LAMP5</name>
        <name evidence="22" type="ORF">DERF_001441</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Cell projection</location>
            <location evidence="17">Growth cone membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasmic vesicle</location>
            <location evidence="15">Secretory vesicle</location>
            <location evidence="15">Synaptic vesicle membrane</location>
            <topology evidence="15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB64"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="21">
        <location>
            <begin position="73"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAH9527427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="302" mass="33204" checksum="CF731BEB0A136E12" modified="2023-02-22" version="1">MNIIHYNSVTSYNCIIARASLVAIIFILLQLIMIITAQSSMLTNRKKPISNSTIKSPGGNLVLANKQAAPKFSYVVWDEQGMVCILAKFEATLTITFYTPSGAHQLIEKIPIDAKAKGRCDYLLDEKPVLDVSWIGGFTFRIIFEKVNDGEKWGVNSIDLLYNTADSLFRGSVQGGKKVARTKEGSLGMFTTMMGKSYFCPSPPIINLYESKTGKPSVVVRLTNVHLQAFQIEMGKFAPISRCSQVSFGSGVAAPLYVSLEQDDSVPVVVGTLTVIVSILVIVGYAVYKSWVFKPVDYDTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBN4</accession>
    <name>A0A922LBN4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Harmonin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">USH1C</name>
        <name evidence="7" type="ORF">DERF_002046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBN4"/>
    <dbReference type="OrthoDB" id="6021951at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002142">
        <property type="term" value="C:stereocilia ankle link complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF36">
        <property type="entry name" value="HARMONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="110"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="377"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="502"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="786"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="951"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1005"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1057"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1124"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="739"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="841"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1033"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1064"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="1125"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1139"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1167"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9528072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1275" mass="138749" checksum="2226686B8E004CF7" modified="2023-02-22" version="1">MVVMPHKLSPAKSTSCLLTAIDNGIHHAVSHHNKDHLINNNLNDGGDCAMCCWSPIPGSSSSMMDICCNGDSSTMCTRNNSNNNASNPNICSSYNSTNTSGTLFIGKCRNVRLRRTDQNQSLGFSIRGGWEHGIGFYVSDVQPDSLADKQGLCPGDQIFRINGFPLDRVIHDEVVALIRMSANDLTLRVRSVGVVPFKGRGPGDKLTWKRLCAQRSMTYSCNGDNVVEMSAINNAGARTMMAATHSSGSSSEVSSFVYHQHHHHHHNNNNHHRHHTHHPTRPRSASSLTTPASSTISSTSDDHLSSSDDQSDLLIHPPPQPPPPPPPSSHNHHHRPLSPPSMPLLHSTLPSNSSSSGSTSPSSTSRPIYCANYNEQHLYIQCHQPGSSLGCSVVNGPASCPGIFIQHVKEGKLAQKCGLEIGDQIVRVNDLDVSVIGFDGAISMLKSLTNISLLVRKGVARHIFECRDHYSTINNDASTSNGGSSQQQTTLNKCHYLSPTKHQQQQQQYFSSTSCSSSKSSKSKSKSNNIPSSRISTTSTNNKKHGSKSKVLYSVPHPPLPVPVPPPVPPPPSTSSTLVSVKTGNKSPAKNSPTYQSHQHYKTASTNLSTFQGTGTTSASSSSSSNYCSAYSSVQISASSINASPGSSSSLSSSSLNSCEKNRCCCKRQRSKDEYQQQQQSICNRPSTFPVDNVSYAHPIPSSSIVPVLPPVVPPVTLFTNVHHVDQVTNAVANSIRILQEVREKEEKLVEASRKLNEEHEKLCREKEKLEIEKKELLLNKESIYHSHHHHHHSSAQHQIADGNHLHNNGSHHYHHPSQSSSSSSSTMTTTSSLLQQHHYSTIGSSTSSISSSSPNCPSSSLSSSNVMIQQPPRPPSSPPMGTINSAINGQCMPQFSFLEEIKAMGENGRRRHLRPVNSIESNNNSSIIDDNNHLDHNSSSAISTVDKNKLLRRPPFGGGKDNGNSSNGVGCSGVGSKDASDNKKRQHELLMEEFRIAHQKMFGRQNRQHPHHNRLNEQQGDVHDNVDDDVGQDVKDCIDKNDKHKDVEDQHYRLSSINNNKNNVDDHKSSLKLSNHQDNDNDSLDNMIPVESSLNKLNSNSSITNTISAPTITTLLNVFPRRNFPNQTMSNQHVKQIPSSSSSLSTLKSTSSSSSSSPSNDRPILSSFSTTKTNTSTINNNISKNRSVEMDHSISLSAAKFVLKKSTSTFALSAPQQSQLSSFKTSTYNKTSKAIDDHRLLSTTTGSNLKSSTASTSTTANRITIKVLSPKIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBW7</accession>
    <name>A0A922LBW7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBW7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="9277" checksum="1D39A6A502D5806D" modified="2023-02-22" version="1">MIHNKIAMYDEFGTIVCLDSGSGYFLYNGWNYCIVKLCGRNGDGGGGGFLLQHFYIIYMLTAAAAVAFIGTWGGCTEIVENYAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCA8</accession>
    <name>A0A922LCA8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCA8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="69" mass="8017" checksum="63F14CADD9B8597A" modified="2023-02-22" version="1">MTHQPICSGAFVVNFLLMIFDLLYKLTYRHLDVGVVCEKRFDDEDNVGRNFNFVSIVQVYALKTLRAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCD9</accession>
    <name>A0A922LCD9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCD9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="334" mass="35078" checksum="10941B88D559B804" modified="2023-02-22" version="1">MLVRSSRSSQSSIVTNRSTYLQLMAKSISTKIIILILALSIVQSMVMVKGSSMEKSSSSMAQLKQNPTSGSSSTSSQSLNGKPSGSSMNSVNTINSGSSSSSTGALLKPLMSTFMSTTSANGVPNPYPFRTMIGNLMFRLRQHRTQMLLIPSVIRIVYQYRRPIVDGLSTAYQSLVAASPALSASAPAAASSSGARISGSSDMDDSESSNSNGGQESDPMMTSASNPYLQMLLASANSPDQQAHRLIQNQVPSTNHHQHQQHPLAMTSGATLYNLMAAAAYQEALQQAAAYTAAAAHPRPASPLVTTATEAFSPVAAAAAALYHPSSYAPFAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCK5</accession>
    <name>A0A922LCK5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCK5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="69" mass="7876" checksum="382CCC8DEA89881C" modified="2023-02-22" version="1">MSTMVSRRSSKKGDDRPLTMLMMRMASNKGHPPSSTTNMNTSSANNVPYEEEKEKKMKEKLCQDHQSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HL96</accession>
    <name>A0A922HL96_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_013102</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HL96"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF7">
        <property type="entry name" value="GTP-BINDING PROTEIN DI-RAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9497091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="440" mass="49014" checksum="0E61B72576881EA2" modified="2023-02-22" version="1">MQNASSSFSSSSQPQQQQQQQQQQQQQWSPLSRPMSSQAMTKRDRYQSSPSMSLSANTSPQPQLSPGKTTTSPLMMMMTKSPQTNVARSPTDQLLVNYQCGILNASTPPLSRRRRHSKLHLRIASELSVDQSESTSHAAIRQEDSQESGQNSAQSNNNNNNRPMKERYRIVILGSSAVGKTAIVERFLYGSFADRHCATVEELHKGEYEIPGGGCIPLEILDTSGSFEFPAMRRLAISTGDAFALVYSIDDQSSFEEIKNIREMIKEVKGNQQPMSPIVVVGNKNDLDDDDDNDDDHSDSDDNDEKKKSKQSLKRRQVKMEMAECECIDWEYGFVECSAKNNKNIVNIFSCMLIQARLNGTLNVIPKYSSKGHHHHHHINDQHGLSTAGSGNRFQQRRRSSLPISELFHRSSSSRSNDRSSGGGSGHGHSSFTKNSCTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLP0</accession>
    <name>A0A922HLP0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_014214</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLP0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF158">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="47"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9493470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="490" mass="54472" checksum="AD2DB550E234F61B" modified="2023-02-22" version="1">MDNDDYDYRSSPPKIRKAQQSSSTPSPTSSYYSLLYPVNDNNLGTNPKQKSSSSLQNNRFFAVLGEPGHLECLVESVPSPIAITWIHNGQIFTSGSANNIPINIDIHEETLKEEMVVQRTSFDIRQTFENDFGYYNCVVVNSYGSDWHLVSLEEKTSFSTIVIFVAIAILILVFVVLTTTILLLSIKHRNLVKQQQQRQNQETESDGEKDSKEHYMGSLDNPDNHNIYSTHSTRTNSSSAHYFLDKNGPTETGTIITRSGSTGSQRSSTSSSFPVYLDQPTSSSSPGPNTGIISRTINSLHNHQRRSPHSQLMNNQAMQFGTMNGANVSHHPHHHQRPTSPPFFANSVFDTASELNSPMISNNNMAKSDQIVAMPPLSSTNYSTLTRHLASIPNSNRNSYSPYLAQQFYQQQQQQQFDNNIQMAANQNPISSPSTIDMYQANPYSVHSSQPIGIAVNNNRVKSTPMPTPPPSLAKELDNCISKISIATHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLQ1</accession>
    <name>A0A922HLQ1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CHSY1</name>
        <name evidence="11" type="ORF">DERF_013250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus</location>
            <location evidence="1 10">Golgi stack membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLQ1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000004">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF11">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9497247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="763" mass="89006" checksum="BB4B9E4EB193D12E" modified="2023-02-22" version="1">MMMKKNYGKSFRTLKQAIHIVIGIIIGSWITCQFRLINYENFKKDILYQLCSYRSSWLYDNDNDVIHVSTKNDLAHTFHSIHNMTSTNHQRKLLLIGVMTAKSFLDTRAQTIYDTWGRDLPGDVLFFTSSNQKTNSNLPFVALPQVDDSYPPQKKSFFMFKFMNDYFGDRYKFFMRADDDVFVNVERLKNFLESLNSSESIYIGQTGVGNKEEFGQLNLDSHDNFCMGGPGVIISFKSLAKIASNVKYCLQNLYSTHEDVEIGRCLRQFAGISCTWSYDMQNLFHHNSSIQTSILNDMIPSKDLLNALTIHPIKNPNAMKNLYRYFKSIDHQNLNFQITKLFRRLNILLIATTNLNYDWKDLLSMKFKTLINIKRLANEAENIGFYPSLKVLFTKTLTNPTWKFFTQKLYTEKSLNPKKNIEKDIVQAFNQNIEQIMNTLNHNSFKKGTLFDYHSLHYGYVRSTQSIGTQFVLDFLMMYRKYQGKRLTIPIRKHVYAVQTFSPTRLLRLEDKPVDIVNVIVPLAGRILTFKRFVRNFIQVYRQDDRLTLTVVLFPNHSNQTVSEIEIIMKEFSGTKNILQVDGKFSRGTALQQSSLLFNNSSLLFFLDVDMLFTEQVLHRVRRNTIFKQQVYYPIVFSQYQNSLKKLITKNESIDDQEFGYWRQFGYGIVSVYNQDLISVGGYDTNINGWGMEDVNLYDRFIASNLTIFRSADPDLIHIYHAIHCDNKLSSIQYEMCLGTKFFSLDSINTISTFIQQNHLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLT1</accession>
    <name>A0A922HLT1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLT1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7267" checksum="D33D5C2A64FCD435" modified="2023-02-22" version="1">MLRKRLVNDERRPPIGDDIGRNMDMNDDGLVITIEDQLVGKVIHDEEDGDEDEDGAACANAWSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN53</accession>
    <name>A0A922HN53_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_015996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN53"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9491264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="88" mass="10123" checksum="623F29C662FD484C" modified="2023-02-22" version="1">MLHELITSIWKEKMSSSRSIKIAKLFLAISIIGSLALILNVHQQQIIDRQRLHEGVLRDQERQRYKQMLRDLSNNNNKSSSSPPPSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNU9</accession>
    <name>A0A922HNU9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lachesin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_014330</name>
        <name evidence="10" type="ORF">HUG17_6796</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7644434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNU9"/>
    <dbReference type="OrthoDB" id="10010359at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008046">
        <property type="term" value="F:axon guidance receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000005">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF33">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324696" evidence="8">
        <location>
            <begin position="26"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="29"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="132"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="229"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7644434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9493591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="366" mass="41504" checksum="8EA0376DA6A5C2AE" modified="2023-02-22" version="1">MFTMFTTIPVLIILAWFDSFSLINAQRNPTISFISKDKVVNIGDNLELKCQAQDAESYPVAWTKLSPSADQEQVFISKGQSIIIPSNRHQILYDDRDSTYTLLIEKIQEIDVGIYRCEITTAVNTKIWADVPVIVRIPPVIADNSTRSVITAVGERVTLKCYASGYPTPMISWRREKNRLLPNQMAFYKGNNLTIDHVTKDDRGTYYCVADNGVGQGARRNIGVEVEFPPFVRAGRSLVKQALQYDADLHCHIEAFPSPSIQWYKDGQVINDNQHYQINTFVRTDEFIDTTLRVRRIEKRLFGIYVCQANNKLGTNQTMIELSESVNIVCPPACDVGFYISGAASYHHQFLSSSIIIFISVSIVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNZ2</accession>
    <name>A0A922HNZ2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase SHPRH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_013185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048686">
        <property type="entry name" value="SHPRH_helical_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21325">
        <property type="entry name" value="SHPRH_helical-1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="640"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="1358"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="1433"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9497180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1598" mass="185515" checksum="29D64EBA55545547" modified="2023-02-22" version="1" fragment="single">NNQCFTSKYDWSKEQEFVDVVEHSSVNDVSSQTTTTTEISEDQNENLQRLTNGHFDNINQQMLKSSGHFIPPWPSNSTNIRSSMSNDQSNWQTSPPPEYCNLLVNSDNSSNCSSLINITRKLYTRIDSIPENVSLDSNSKSSQETDNSISLQSPSTTKNERQAQDQPRPTKTANLTAVKSNKSERIHAEFETFEFQQYQNSLKCQLNDVDYQPNLYLNFLNLFCNSVEELDFDLEDPLKYGYFEIELFENEESEDSNDNMFAFASMCFDVQDSWEESSDYDHDNKYNHLILTANKQCYLLESNGSKQILHRLINSQELNVPDDFHRYFTHHMAKSRQFCRVKAIRHSNTSFVINWYLSLKIVFTEMATLEVAMATSKNDLTIALMAFTRGNQLFESNSRHEFGNNTEIENFYQTIAHRQKSDPCYEFETIVIDSKNLRPKLWRHQQMALKWMLMRETSKENVNFDLAIRFEKIFNVKSGENLYFHSTMGHFLTEKVYHEYLNHLKQSPTKGGILADEMGLGKTVDVIGLILNNPKPTSNTDNMNFLLTEQNLFQRSKNPLTGEVRCHCGILNRNSSVQMEAIDLEQLRDQCLRQQYHLMDNLIQCLMCGNYQHLECSCYPIEQSQQFGYVCSHCWPHIDPIDSPATLIVCPTSILSQWIKELSIHINKPDVKILKYNGVKCKDYKFPPELANNDIVITTYEILKSELDFVAPHDYSHLRNSRRYYTPVSPLCSIRWWRLVFDEAQLVEGRTTRTFRMAKSLHSVHRWTVTGTPIQRNIEDLFGLINFIGERPYNEEVVWKNDLYNPFCHDERDTLINVMARCFWRTSKASVFDEIRISKPIIVMEPCNLSQIERDFYLQEASNCQQSMMAKLAKTSSEMKISHLGSTVQSVIFNLALRLRQICCHPQMCLKVKLGDYCSIQDVLVKMIDDAKYDCEKNHREKIASINGMAACYLLQNDFKTAINMYKEALASINNVGDDIRTDKTQTYHIYYNLSQILEFVGCTQIDSNEQPMDPFNGSQAILAPGDSKPCLPSSDELSLEPDDRYLRLKAKQLYQNYLNSAQLSLLTADRYRRELINKCDQLKQKFTLKGWWLVYALQELSQVMNVNEMIVSLLEILSDRRQLIDPIGPRSIESIRWQLCEYLNSFEEVRQQIRDAFTRLDHESLSGNPDRYIDCHIRPPPVQSKPDRQERCNLCKTESVIKNFEKIIFQFNQSRSINTEGEDENEADNWNENLCLVAIRKVGIWFKSRTAGSARDYGVTVADIDNFSQYIDECKKEYKAHRKCWRESSELVLRIDELNQAQTRYEHGVDSLSLFHRDSSAKEMAEEKLCSNQQRLKYLNNLKNTLKDKDSIDSKVCSVCWSDLIRYSVLTCGHLLCIECMRNISKHSEILSRCPVCRSPFDHSKICFVDSNLLVNKSSVMVEGNWSSKIVAIIRCVKRIHQESNDEKILIFSTWLRMLQLMEKALQKNHVESILISGSGDDKFAAKIDQFRQSDSCRVLLLPTRFACKGLNLTEASRVMFVNPILNKRDELQAIGRVNRIGQTRQTYVHKFIIKDSIEELIENYNKDCNYRSNFTNGEFTDLTVREFCALFNVYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP22</accession>
    <name>A0A922HP22_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TRMT10C_3</name>
        <name evidence="8" type="ORF">DERF_012010</name>
        <name evidence="7" type="ORF">HUG17_9202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7638097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP22"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="6">
        <location>
            <begin position="97"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7638097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9501144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="276" mass="33076" checksum="2E245F8896117104" modified="2023-02-22" version="1">MIIRKYSDLVRAKRKLIQAEIEWLRYSKPTIVPMNISIENLHYLEQMFETKKYRRLCWLDISYRARYNYLCQLQQIESFDGQSLIAPICQAKIDRLEWRRRLSMIPFVPNIAFDITFDNYMSSLECKNLAEQLIRIIRQNRQEFKTNWFNLHITGLLQSESTRNFLDQYFDSSHRHNYPNVFFHNQSFDNLFPHEQIIYLSPHASETIDPLTIDPDTIFIIGGIVDRRKIIELTVSKCKKLGLKTKRLPLDLSDRKQIKSLDDVFRMIFTMINNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ59</accession>
    <name>A0A922HQ59_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">tRNA (Cytosine(34)-C(5))-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NSUN2_1</name>
        <name evidence="8" type="ORF">DERF_013725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ59"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000271">
        <property type="entry name" value="NOL1/NOP2/Sun family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="88"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="193"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9497765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="388" mass="44178" checksum="4D2D8DA05F1DE24F" modified="2023-02-22" version="1">MDTKANVNKKHKLRKFKTKRQKRLERANRTDDRDTIPRKNSYAEIIKKNENFEDYYRKQKLLESDIEFAEFLRVLAEPLPTTFRISSFCQGQAQRMRDIIQSDYIKDCQLENNVELIGGKKLDISPIPWYPNKLAWTINLTKTEIRKSRTINLLHKFLICETETGDISRQEAVSMIPPLLLDIKPGQTVLDMCAAPGSKTAQIIEMLHQESGSTFISGDCKTTNDVKYLDGLVVANDVDNRRCYMLAHQSKRLSSSCVVIMNHDAANLPDFYKNDPEKGKTVLKFDRVLADVLCSGDGTFRKNYDVWTKWSAGNANNLHNIQIKIAKRGLELLAKDGIMAYSTCSLNPVENEAIIAALLNMAQGDLELWMDPPFYLNLNVILVSIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQF7</accession>
    <name>A0A922HQF7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BTB/POZ domain-containing protein kctd5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KCTD5</name>
        <name evidence="3" type="ORF">DERF_012618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQF7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18362">
        <property type="entry name" value="BTB_POZ_KCTD2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000005">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958:SF29">
        <property type="entry name" value="INSOMNIAC, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="197"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="367" mass="40898" checksum="736A917FEAA53070" modified="2023-02-22" version="1">MSQNNNKQQLDSTEFDDTTSPKSVGDDDGDGNDPNPACISVTQKSSRIIYSTSGKSRSEEDNQTKSLSSSKMMTATTNLTMKNDINSKSDDQLSSSGSSSSSSSSSSSAIIADICSTSSSSPSTSSGCLLVENCTIETNGSSGGGENISYHDCQSPTTMMMNHHNHNNNNNNCQRTMNTIEFNNNNNNNGKTKNSNEWIKLNVGGTYFQTTRTTLCSDRNSFFYRLCQQDDNKNSLASEKDENGAYLIDRDPSYFAPILNFLRHGKLILNKDLNEEGVLEEAEFYNITSLIKLLQQRHLDRTMNHNPSPDSSKNQNVYRLLHCRESELSLAISTLSDGWKFEQLLPNFPNWTTDYFVVVSREYPIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQK7</accession>
    <name>A0A922HQK7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Mitofusin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MFN2</name>
        <name evidence="15" type="ORF">DERF_010590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQK7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09912">
        <property type="entry name" value="DLP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002843">
        <property type="entry name" value="Mitofusin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006884">
        <property type="entry name" value="Fzo/mitofusin_HR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF3">
        <property type="entry name" value="TRANSMEMBRANE GTPASE MARF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04799">
        <property type="entry name" value="Fzo_mitofusin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111479">
        <property type="entry name" value="Fzo-like conserved region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="103"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="573"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="712"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9505818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="765" mass="87424" checksum="9A26E394124EFE8E" modified="2023-02-22" version="1">MASIINRSLTIVSNGLSSFSHTATNNNNNIMTLDFNSTGDDNPLRIFVSAKKDINDLFIKAEKFVKNVDQFYRSYDESMFEQNNINFIENSIEKISGIRDVLARNNMKVAFFGRTSNGKSTVINAILQNKILPAGIGHTTNCFLQVEGTDETEPYIVLEDQRHNIESVKHLANALNTESLGDSTLVKVYWPKSKCSILHDDVVLVDSPGTDVTANLDKWIDLYCLDADVFVLVSNAESTLMQTEKNFFIKVKEKLSKPNIFILNNRWDASAHELDSLDLVRKQHLKRDKDFLVNDMGVLDENNAQNHVFFVSAIEVLRARLELEEGKQINISNYAHGFESRFREFIDFEKKFEQCLSKSAVQTKFGQHTLEVIKMTDDFNQFLMEISTKTIDVRNEKRNQIKIMKERVQKIKQQFQIFTNEVKLQICNLVKQVEQKVSTALNDEIRRLSTLVNDFDRPFNTDEISLNLYKKELHTHVEQGLGSNLKSRLSSALSCNVEATQRQMIDGVKRFISEMNFDQLLLNQVSSQQDFKLIYRINCESLCSDFQEDLEFRFSYGFFQLVRVLTGAGGGGGGSSNGMNGSKNEMDKSNLSLSQKPSNSLSHNQSLIRTTTDHLDLLDKLASSRSTIIVLAVGGSLIRVIGWHVIAITSAIYVLLYVYERFSWTTRAKENAFKKQYVAHATKKLRLIIDLTSANCSHQVQQELSSTFARLNRMVDQFVEQMQKEIQKLEQEVQLLNHQEQMIAVLKNEVRTLTSELQNFSEKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS00</accession>
    <name>A0A922HS00_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS00"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="181" mass="20971" checksum="49615BC697D8ED89" modified="2023-02-22" version="1">MVLSVTTLILNETLTGSDEFFIYSLTIFILHDHIIIGSIAIQSNSLHRPAKHLYHYTGITGKNSICMKTNYEDLYSRLICGPRYGPRLAHDWCHYTLVIFNTDRFYLLLYLFQYNLVYITVNDISLMNDNGRGLHIKKTKQNRLNDWYSQKSSRKKHGTTNVIDDHNVSNCVTSASMFLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSB2</accession>
    <name>A0A922HSB2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphotyrosine interaction domain (PTB/PID)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">APBB2_2</name>
        <name evidence="4" type="ORF">DERF_013769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSB2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01271">
        <property type="entry name" value="PTB2_Fe65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000034">
        <property type="entry name" value="amyloid beta A4 precursor protein-binding family B member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039576">
        <property type="entry name" value="APBB1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058">
        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF8">
        <property type="entry name" value="PROTEIN FE65 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9497813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="212" mass="23371" checksum="3E209F0F821BA8A4" modified="2023-02-22" version="1">MMDNFEFPTPIEEPKKCIQALYIGFIPVTKPMGVDILNMAIEEIINSLKMSLTNENHDEIELMRPVLVNISPSNIVVECQETGATLVECRVRYLSFLGISLDNVKRCGFIMQVNEKEFVCHCFQVEPSAGALCKIIEAACKLRYQKCLDAHSNKQQPKQNNNSVATSKSTTTTTTTTTTTNSSPVAALKSSISGVFSKILNKTSTATTTSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSB7</accession>
    <name>A0A922HSB7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RCC1 and BTB domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RCBTB1_13</name>
        <name evidence="4" type="ORF">DERF_012324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSB7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="134"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="317"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9501479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="435" mass="50137" checksum="9D44766BF7259BFD" modified="2023-02-22" version="1">MFSSSTMARSPIESIDFKLFQDDFKNIDQKFLQSVVSIFIIFNYEKSKLKKEFLMMTEKATYAYGEEICSWLSLKHDMTKPQRISLFNDFGQLGLGDEEDRDIPYLVAFSDPDSTRIKNIVAGEDYSLFLFKNGQVCGCGSNYNGVLGLGDTEIRSTPTKIPIENVKQIACSKFDSFLLANDGSSYYAWGKAKYRKWSSPKRFDDHPTGELGLGDENNRSILTKIPIENVQQIACSIFNSFSLVYDGSSYYAWGETKHDPNWSSPRKLNDSHSSFAYASVQVLDSPLTFGLTSTIYEFGSHDSLSYKSILRLFDNQDNYDVKFKIDNDIKSGKFYLKSVSKYYRRMFSGNWSENDQVIINDYSYEAYYAYIRMLHTGKIHINRQNITELVDLANCYGDERLMEYCQTFIRSDLNAQTMTTHLPLIIKYKMKEFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTQ7</accession>
    <name>A0A922HTQ7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_010798</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTQ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="25"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="692"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9506052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="935" mass="106785" checksum="5DC9265387147D79" modified="2023-02-22" version="1">MMSNETDVCCEFKKSISLCWKNLRYEVDEWFMVDGWQPRRRRKVILNRLNGSVRINSLNALLGPSGAGKTSLINCLIGNVPAKNISPDTEIYINSEIITKSSNSLVSFVPQFVHEIILGRFTVLETLYYAFCFKNPAHYHGRAYQHIQSTIQELMLNPKVLQTRFENCSGGEQRRVAIAQELMSIESKPQFLFIDEPTTGLDSESALVVMKCLQRLSTQNGITVLVSIHAPSSDILDMFDQLYIIAKGGVCIYSDQPGRLRSHLNQITGIALNEDDSPIQEYLRIASNGINDEQVRKLTQESVQQDHQQLTAQFSIPHYSRKFRSSDLWTQFRRLLRLTFIADVRHIIGILILIIITLITYTSITNKDMVIPRGCIPFNIEHLNQTCQNKLKEDRLIGTLIMLLFLIILLTFSLGIAMYSLMTVNFMKILRHEYRTGWYSFSSLIHPVHANDLITLIFIVIISVVTYYVTSGILYIDEYRINWYRFGPLYLFNIVSFLYGQSFGYLLTSICIDQFEILLILCQVVVVIVNINNGLIVISDLMDKPFYRTISHLLGSRYIADGYLYTYYGIDRCDPQTEYSQILKQFFVDTDYVYSNLEKPMIVIIVIRIISIIVMRWTFSNVNNGKIVSATKQETLTKILTPAIEIDFHEKSTFVQILDSNNNNVEPQMTKNEFQQFCTGRYIIGWRQLTLFATDTIYEVRPTPESLDDLGDKLILRNLSGQFQFGTLNAIMGSSGSGKTSLLKVFNGKMKTKLTGSTQFYLSRFVPIRTCYIKQEVSKHLIPGLTSKQSLVYASKLKNCHETQTIDHEQVADNLLNELDMTNTANTLVQNCSGGERKRLALAMELTSVRMPNLICIDEPVSGLDSNSALLVLRCLRRFIARHPDITMLVSIHQPSTEQLDMFDLCYVLAFDGLGIYSGQPARIKSFLSESIFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU62</accession>
    <name>A0A922HU62_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU62"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="75" mass="8054" checksum="304A0CE661BB4BA6" modified="2023-02-22" version="1">MKIIKIECELCMKMAIGIDVIIDVVILITDTGNNKFIGVSTIGKKLYHMFFSPYESNISCYGHLAATAAVAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVJ6</accession>
    <name>A0A922HVJ6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVJ6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9507014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="210" mass="24175" checksum="1E1A06B805BD0C8B" modified="2023-02-22" version="1">MNTMVIEFMKMMKQSFCSFYTIMINTFDYNHDIKQSMMKRFIVHNHDDNDHDHDIENGGHSLLFDNENYNDHDDYDDGEMTTENNEESEAEYSDDCNSESTDGTTNTSIKTSLSYSNDDYNNEILKSNSQPESESESGSSLLLSKQQEYEKNLPNQTTITMCSLSANNNYDRQLIDNNNEWRTIFLGNNYDSPPELSFSSTSTSTSFMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVU7</accession>
    <name>A0A922HVU7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVU7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="98" mass="11637" checksum="45EEF29D1596E6D2" modified="2023-02-22" version="1">MINGRQYLMENHMNFSIFMNIIAMKMMMMIMAVCIDTTKKIECMEKKNSFKNSINVLGNIRLNQTFWKNINLNEPIIQVYLERITKKIIKIYILLTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWB0</accession>
    <name>A0A922HWB0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette sub- E member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ABCE1</name>
        <name evidence="6" type="ORF">DERF_011545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWB0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="80"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="635"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9506833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="782" mass="88509" checksum="D44914FC4BAAF408" modified="2023-02-22" version="1">MAPPKHKQQETQESLTRIAIVNHDKCKPKRCRLECKKSCPVVRMGKLCIEVTQNDKISKISEELCIGCGICIKKCPLGAITIINLPSNLSSETTHRFGPNSFKLHRLPTPRPGEVLGLVGTNGIGKSTALKVLAGKLKPNLGRYGVDAPDWQEILVYFRGSELQNYFTRILEDDLKAIIKPQYVDQLPKTIAGTVNTLIDKKNERKNKEEICELLDLTDAILERDVSELSGGELQRFTIGMVCIQNGDIFMFDEPSSYLDVKQRLKAAEAIRSLLQVNKYIIVVEHDLSVLDYLSDFICCLYGVPGVYGVVTMPFSVREGINIFLDGFVPTENLRFREASLVFKVAETATDEEIKRMCRYEYPRMIKRTVRMLLHEKIRDFFTHPHFQAEVVKPLQIDNILDQEVRHLSGGELQRIALILCLGKPADVYLIDEPSAYLDSEQRLVAAKTGFIVEHDFIMATYLADRVIVFEGTPSIKTVATSPQSLLSGMNRFLELLNITFRRDPNNYRPRINKLNSVKDTEQKRGVKGFKNAKFKKFKTKSEAEEFIHIHHKSTTSSSSISNSNLVPKILPTTSTANNSAVRINAMSMPRSSSHQPSKLTSDDKKLTTGIFSSLKCPKRPRSRKSDFLTIRRNHLGDPIVYTDGACCNNGKRNAKAGIGVFWAIDHKDNVSRLLVGRQTNNRAEIEAAIVAIQTALKNNYRTLDIHTDSKFMIVSMTEWLPKWKRNGWKLSTGESVKNKHEFMRLDEEMNKMDRLIWTKVRAHSGDYGNEMADQLATNSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWV4</accession>
    <name>A0A922HWV4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWV4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="9557" checksum="34481DD5BB4A3E28" modified="2023-02-22" version="1">MSMFKLLPGSKLFHYDVISCLKLNLKKTSSFLGPTFFYSCHCSIKPMLTMSKRLTRDIINLTIKLLISGLYHHFLANNCEKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWZ8</accession>
    <name>A0A922HWZ8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWZ8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6785" checksum="5A6C0F02040EF662" modified="2023-02-22" version="1">MTTIIIENSIENNDGDDVDDDDNNNKQKTMLNMSTKIFKKTIVSDHDHSTSIIPGEFTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX53</accession>
    <name>A0A922HX53_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX53"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="134" mass="15973" checksum="FF2332B71E2BE5E6" modified="2023-02-22" version="1">MMIQLSIEDGELITRIKSVSDELIELSRMNNQSDNIDCNQRKSFLNRTISMLIWPTSKIDETVIILYTLDHKLIIYPKAKTWMRDLFKVFQLTNGYELPMSIFVTKLSQQFDDWFQLAEHELRYHGVFAMKFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX65</accession>
    <name>A0A922HX65_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_009836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX65"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0799">Topoisomerase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9511368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="182" mass="20799" checksum="EE047EF0BE32F962" modified="2023-02-22" version="1">MLIITEGVSAKNLVNDGFSVGLDKFGIFSLRGTMLNVRDASDSQIMENDEIKNLATILGLKYDLKYTIDEIKSLRYGKVIIVTDGSHIAGLILNFFHFMWADADKLDTPEKIDRYISAQIPPDNPDYEFVREIVLKHMVHTCMPNRCLNEDGECNKKFQKPICNDTNRCIKGFENERNSPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HY19</accession>
    <name>A0A922HY19_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taspase, threonine aspartase, 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TASP1</name>
        <name evidence="4" type="ORF">DERF_006798</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HY19"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9516034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="358" mass="38576" checksum="14AC3EC893896F2A" modified="2023-02-22" version="1">MVFVAVHTGAGFYQSGKRKKFLEVCSQACETAIKGWKNNSTAIDGVVEAIAYLEDQMITNAGFGSNLNSAGYVECDASLMDGRDLLFGSVGAVQSIQNPIKVARLILDNQRLKPPLGLIAPNFLAGEGAKKFAVSHGLEDYELISGKSLNIFNKYKRQLEECETASIDDKHKKYDTVGAVCIDDNGCLACGVSSGGLILKKEGRIGQASILGSGCWSEGNVAVTTSGIGEYLIRTSFARKTVENLNGKNDDTQNIVEKLVQVFNDNFFESPLMKNVPREDHLAGILGLSTDTDNIEMFWGHSTKSMCIGYMDSTFTSGKSFISDLDCSVKPGISLIETVALPRLAGFGCEGCGFHPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYJ4</accession>
    <name>A0A922HYJ4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYJ4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="8935" checksum="752020087463E4F6" modified="2023-02-22" version="1">MLTIVVDDDNDNGGGVMSSGNDNDVATFPVVVAVVDVDVDKDVDKDDEVSAIIDPEAALFDPFCDDDDDDDDNDDYLAPDFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYT0</accession>
    <name>A0A922HYT0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_010553</name>
        <name evidence="15" type="ORF">HUG17_9818</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYT0"/>
    <dbReference type="OrthoDB" id="6514465at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF8">
        <property type="entry name" value="PROTEIN TWEETY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7643127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9512156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="481" mass="55284" checksum="4A1CFAC02E347610" modified="2023-02-22" version="1">MDFDTVPLTNGSGYNISTLVNDFHSISRYGLDFRRSVATIRDHDLQEYGYQMATFAIMSGIVFTLLTFILLLLCCCTCFFRSSAKIPMNNYQYQRKRNNCCQFSSIIIILITILTMVTYIIGFVGQQQFNDFTLKTCDTIDLFVDKIKDVNKTTIIIDKVEIIFNDIDKSMAKIKNELDTINIADIKEKFESIKSEYDKISVKIRPSLNDIENQIQNNGNLEEILNQLDKSHEHCHVYQSDIRKALLITLIVLSLFTIIFIIGLFHGCLRGCSCVFGYIFMLMIALFGTISFIGLVAGSDFCLYSKQLPQTLEMDVSLRKNFDYYLYCQTQRPLFVQAYWENLTLSSSSSNDSEDLQSLFAKIHQFMIDARQQLKNVDENFVNIIDECQQYESQIDNVRQLCSDLKQLKPTVQQLKPITIEVDNVVQTVECESITPIINDMLTNLCTNFYNSFFLFFLNSISATIGYFLLLCITICILMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYT9</accession>
    <name>A0A922HYT9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="3 14">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PLCB4</name>
        <name evidence="18" type="ORF">DERF_007163</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:60648"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:143891"/>
            <dbReference type="ChEBI" id="CHEBI:143892"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="13">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="3 14"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYT9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000024">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="17">
        <location>
            <begin position="516"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="16">
        <location>
            <begin position="633"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="849"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="951"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9516424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1053" mass="122561" checksum="15DED33B1915FFE4" modified="2023-02-22" version="1">MTKAYEFNWCRTVPSELLNGNTFDVWEEVFIGSKEKGEIIYEQDALVQVDKFGFFIYWKSEGKEGQVLELCQVNDIRAGGVPKDIRLLAELQNRYKYNLEEISLTICSGTDMVNINYTHIVGPNPEIAKIWQLGLRSITNNNKANNVCPMICLKKHWMKLGFLSDSNGEIPVKSVAKTFASGKTEKYVYQCMKEVNLPFEKNDTIHPDDWTFEKFYQLYHKICPRSDIEELFHSITQGKSNYINAKQLIEFLNERQRDPRLNEILYPIYDEKRALEIMATYEQNPDLTKQGLLSQDGLIRYLMSNENAPVFLDRLDEDNLVGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIYAIRDCAFVTSPYPVILSFENHCSKKQQYKLAKYCDEILGDLLLREPLINFHLEPRIPLPSPNDLKYKIVIKNKRLNPEDEKVELELWKKGQLAQDEDEENEDPSAILTTEDIALDKKEYAEPEQIAMANYRYTGATQHIHPYLSSLVNYAQPIKFQGFDVAEEREICYHMSSFAENTALGYLKTQAIEFVNYNKRQLSRIYPKGTRADSSNFLPQVFWNAGCQMVALNFQTPDLPMQLNQGKFEYNGGCGYLLKPDFMRRKDRIFDPFAESPVDGVIAAQCSVRVISGQFLSDKKVGTYVEVDMYGLPTDTIRKEFRTRMVPANGLNPVYNEERFVFRKVVLPDLAVLRIAVYDENGKMLGQRILPLDGLQAGYRHISLRTEGNFPMSLPMLFICIELKIYVPDGLGDLMDALSDPRAFLSAQEKRIAQMKAMGIEETDIQNLALIKQQRDDEIRREEYKIDNITIDMVKDDKFYVRILRKLNKEMDNLRKKHQKERTQIQKNQCLAIEKLMKTAKSVDCDDMSQDPTMMELVRQQIKQWSEMIDRHHQEEWELYKTNTISESKILRKLFQQLQILQVKHLETLFEKENKEMKAKQAKISVETAKEVANDKTLRNKAEKERRLKEKNSNNTKKFIEERKAAAVRQNKEREKIKKIHEKQCQDLEKFIENVCNQVKFDKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZC9</accession>
    <name>A0A922HZC9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZC9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="851" mass="95434" checksum="5C5ECCC38045BAB5" modified="2023-02-22" version="1">MATLSPFIKTVPSSSSTSMITNHSGTITKTSPSGCLSLLSSDIEEDLGILDLNAREFNYICRQEYWLLNDDEYNPETNFSYDIVLEWIDGYTPMKSDEDYKKFFHVTNNDNNHHRFQHNLSINGHNSHRNHLTPINGYNRFDYLTKSSAISRTATITKRKIENINNNNDNQLNTPTDSSSMNTTVRYGTITKGMIARPFLTNNNHTREINRTFDIFESKVEFNESPTISSSDDNEQISTLNINTPSNNHNPINTNTITRTKSSQCDLSNLSTSETDHGSDSNQVNNLMTTSDDVVEEFGLSSDSGLTDNNDLKRPSLKSQTLDASDRNYPTISRNTSSTLFLRREASQGQINNNRINNINNRTISRTPQPMKQVYLVSSNDDLLSSDCSTLSLRSSTMSGGRSEPNLLDAQKRTTNGSAQLSIHNKNQQQQPKPRLSQIQVIQAPKFQSRLMGPTGIAVPATNGNRISRIALPSTNGVSSQPSLVNIRSSGIPGNKTTSIRSTNSFGSMGSIRDQQLRQNHPSQQQSNQFQMPRAVSQIEMNNDDDGQQQDFNGNNVQQQRFGMGLDRKSTFRVTNRTSSSPSSSSTLMAMTTMLDGQQYLNQKPVMNNQQTNDHFYISNWNGNHHTSNGSRKQQEVDDVIAIQSMPYLSSNNNNNHRSSSPSSLSRNKKLPHSKQSSIVATKSAIAYRSLMPNECSNHNDDNITSICSDHTNNNNISNAAAKSIVLSSRIPGLMNNRLSIPVYGNNKGQLQRPNLINNYEQMPNQIKDSRMLNNCMESAPHVMVMPVVNIDKSTNLCRQQQQQQQQQHQQQQKQLNRTIITATAHHQPSRGFKINSCDGYEDNSWQDDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZE3</accession>
    <name>A0A922HZE3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LGALS9</name>
        <name evidence="4" type="ORF">DERF_010482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZE3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF147">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="31"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="231"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9512074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="370" mass="42105" checksum="B15CE30E237F9673" modified="2023-02-22" version="1">MALLDNLKLVEIIDRTRLISDVPQPTLPACCPMPNGGHLRPGSLITVYATCPSNQGRFRIDLYASNCQHCRSNDDGKTSLYDPNKRIVALHFNARFGEALDGSSYIVMNSFHQGKWDQDERSTVFPFQPEQSFCIMILTEEDRFRIYVDGGEQPHYQFKHRFPISDIGRIHVEGPNLTVELIEFREPGIEPSQSLSSSDAIKPSDDDNNIVRKTRDVMVTTTTTNVALSIPFFEHNTNLEKPCDIYINGMIMDPFNKYFVINLAHTGGDCEMKKQNIPIHISIRVDQSKIVRNSLINGEWGQEETNMEGSFPFTIGSMFEICIKNRLESVSIIINGQSCFEYNHRHDPKTIDTLEINGSVRLDSISYRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I038</accession>
    <name>A0A922I038_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I038"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9512022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="81" mass="9578" checksum="6076B4CC00AD04FE" modified="2023-02-22" version="1">MNNNNNHHEPHQSQQTINVIKNQQQTPSSLLWYHHRNHTKINPLPQHYQTFTQPSSSSMIQMSQNKQTINDMDFNVLIKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0M8</accession>
    <name>A0A922I0M8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Malvolio</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_006671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0M8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF33">
        <property type="entry name" value="NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9515896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="67364" checksum="D8C501F5F2124782" modified="2023-02-22" version="1">MIIMSQSDNQLHPLEIMNSSSSNENVVSNAIRSDSDNQTQRESDHLQKDTNVTKYGLISDAGDNDNHLIVNDDDSVDTVGQTIDPYLHSYVSIPAAQDYSFSWRRLWTFTGPGFLMSIAYLDPGNIESDLQAGTATRYYLLWVLMWSTIMGLIMQRLSARLGVVTGLHLAELCHRRYSFLPRILLWIMVEIAIIGSDMQEVIGTAISLYLLSNGKIPLFIGVLITISDTFTFLFLDKYGLRKLEAFFGFLITIMAITFGYQYYIMKPDELSVLEGLVIPSCHNCDSDTVLKAIGIIGAIIMPHNLYLHSALVKTRRIDRQKKEEVKDANRYVFIESAIALGTSLLINIAVTSVFAQGLYGKTNSQINKICQNSTVPDKVFPNTNDHVEINIYKAGIFLGCTFGMEALYIWAIGIFASGQSSTMTGTYSGQFVMEGFLNLHWSRWKRVLLTRTIAIIPTLLIAFQSMSQLTRMNDLLNALMSLQLPFALFPVLTFTSSRKVMGEFANGPLTKLLVTILSVIVISINLYFVYDYVHNHVVSHILVYTFLFLFFIFYILFVLFLCGSYLAVLGFEFVYNIPYFGPWFKESDYNEYRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I150</accession>
    <name>A0A922I150_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein 62</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TMEM62</name>
        <name evidence="5" type="ORF">DERF_008802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I150"/>
    <dbReference type="OrthoDB" id="27234at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056229">
        <property type="entry name" value="Ig_TMM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056230">
        <property type="entry name" value="TMEM62_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795">
        <property type="entry name" value="HELICASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14795:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24384">
        <property type="entry name" value="Ig_TMM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24394">
        <property type="entry name" value="TMEM62_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="606"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="120"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 Ig-like" evidence="3">
        <location>
            <begin position="374"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM62 C-terminal" evidence="4">
        <location>
            <begin position="517"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9518211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="750" mass="88795" checksum="95B1B21302DAD134" modified="2023-02-22" version="1">MISNCLMILLIGILVILLSLAVLFMLISPSRYNIIPDNRISKFFYHLSLLDNFHLNSRQKMLTKFTLIFLLAFILVAIFVSSFLHLINTEDDYNNHFQINQTQILNDHVQIDDKYENLFWFIHISDTHLSYFRDHDRKTGMIEFCRSVIPIIQPSVLVLTGDITDARTKFPLGSEQYREEWIMYKDVREQCLKANPNLKWLDIKGNHDTFNSYKNHNDFNNFTVQSNMSADGRSYRYEYKASDGNFYSFIGADACLKPGVRRPFNFVGQFEESELNKLSKFKEDSRESTYTIWYGHYPTASIYNRESFRKIINGPYLCGHYHTIHGLVPNMITTQQQGYLEAETGDWKDYRIFRIVAIDHGLFTFSNYYYRPHHQQPLIVITNPRSILHQMEHLEPFWRTANSTHIRALIFSHRQIIDAKAYITKQQKFNRDEVLETFELKQIRDSLWVSPWSPNKYSKGLYFITVITSDDHYSNQLTVPFSLDRSKSEFSFLARLILRFDFRTITMFLYSWGFFMATLPLIFLRIFTSNDDNYIKYMCNLSRRRYIRKVIFKLFLLSHQDKLFYPIIILPFYSLVGPWFLAFLVSDYVGIVFAWGQFIDGTFLPVGFTFVFAAIFILIFHLPFMVGLSIVVYLRYVEIEKNDQNGNEHSDDSPRTMRISSNRIFKKMYFYAFICVILTAFQFFTALIFYTSYGFLAFITNFYVWSCLVYLMLVKFALNLDGHNFKLMAKKMTYQPCSQTRNNINDDEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I253</accession>
    <name>A0A922I253_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I253"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="123" mass="13227" checksum="DCCB5414EEF40365" modified="2023-02-22" version="1">MKRCLTLFSAILIINNNNDGGGHNNEFTHSAVAESIDNAAFNDSFLFSATSSGNIGRNERHSSNIRCSNCSVWPGIKRNSETNTRSCSSFSQSPNSDCNENEANVAATSSVHGNFPLNTSCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2M0</accession>
    <name>A0A922I2M0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">ROCK2</name>
        <name evidence="30" type="ORF">DERF_004560</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">Derf</strain>
            <tissue evidence="30">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="30" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="30">Derf</strain>
            <tissue evidence="30">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072518">
        <property type="term" value="F:Rho-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901888">
        <property type="term" value="P:regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd20813">
        <property type="entry name" value="C1_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01242">
        <property type="entry name" value="PH_ROCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000017">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000047">
        <property type="entry name" value="Rho-associated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000308">
        <property type="entry name" value="Rho-associated protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015008">
        <property type="entry name" value="ROCK_Rho-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF73">
        <property type="entry name" value="RHO-ASSOCIATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08912">
        <property type="entry name" value="Rho_Binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103652">
        <property type="entry name" value="G protein-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51859">
        <property type="entry name" value="RHO_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 21 23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="20" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="83"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="28">
        <location>
            <begin position="345"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="RhoBD" evidence="29">
        <location>
            <begin position="864"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="25">
        <location>
            <begin position="1098"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="27">
        <location>
            <begin position="1216"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1335"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="472"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="704"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="780"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1347"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1362"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1383"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1452"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1481"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="KAH9520876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1510" mass="174082" checksum="BEA5AF77F9EAE152" modified="2023-02-22" version="1">MADDQMIKIAEDNRDKRVTRLEECLLDPKSDLNIDGLLDCVQAMVIDCNHPTLRRIKNIDLFLQKYEKYNDLIANSRMKPDDFNVIKVIGSGAFGEVKLVRHKYTKKVFAMKVLSKFEMIKRSDTYFWEEKFIMAHADSDWIVKLHYAFQTTTHLYMVMDYMPGGDLVSLMSEYDIPEKWAKFYCAEVVLALDTIHLMGFVHRDVKPDNMLLDHRGHLKLADFGTCMRMDDNGLVHSETAVGTPDYISPEVLRSQSGKECYGRECDYWSVGVFLYEMLIGDTPFFAESLVGTYGKIMDHKNHLHFPDDVEISVEARSLICAFLTDRLNRLGRNGMTEVKIHPFFQNEQWTFDNIHQCIAPVIPELCGDDDTSNFNSNRIDIRKDNEHFPEPRAFAGNHIPFIGFTYSGDNALLCRKRRHSQARKQSVDSDSDLMASRMTDLSDPDKRSLAMDTNVELDHKFRLTIIEKDRQIDSLQNDKAYLEKHLNSLRQNLIKVRATLDQETENRQAAEKSIIDFRKKYDSERTQRIQTQNALNEKNSTMEKKLAMLTEMLQKEKENFARESIKMNDLQHTIRNQELVIGEMKNKIAMFEKISDSKEKDVSTTREELNIATNLLNNFKAKVKQLESQIIILTNELHELRPMATNNNKANRPMAIVTPDQNDNSIVTTTNANDDHNTEVLIHSDQFQDVSALKSMLEGEIHKRQQLETVVKEREQEIDCLKIDRQQLQQQVQSLEKDRSFIIDNDDNVDNEIKQYLSDNRNLSDVKILAQKLAFSDSENQLIKSQLEEAKKVYKKLSIDYSDMKIRLDTEHCFSEIYKNQLNEISEELNEKTSELNTLTREKTDIVQENEYLKNQLKHDTNYKERMTTLESEKSDLENELDELRKQLANVKKDSHTAIETLRCNERELCDYIQELKKKNKEFEIKMRELNNNVDSIATVQQENQTLAKQLQQEKLLKEQAVNKLAEIMNRRDMKMNDKKAKSSIVMELKKKEKECRKLEQELNSERDSCSQKISKLQKEFNDIQAILQEETQQRLRLHMEVAAKDAELEQFRSKNTRLSEENLSTTSSTSSVVVGTSSSYLQQSTQSIPNTVEEVDESRLEGWLSIPNKQNIRRHGWRKQYVVVSSRKIIFYNNENDKAKSDPTLILDLWYIKLFHARSVSQGDVIRADAKDIPRIFQLLYACEGESRKPGGDSSSHLDNHFHHGKDSTTIEHKGHEFIPITFHMPTSCEVCLKPMWHMLKPPPALGCKGCRMKIHKEHVDNKQENSVTPCRVYLKNSAKELLLLAMTSDEQQKWIHFLCKRIKQCGYAASNHSAHQRHQSNLSFQSNYSSDSIASVKTTPDKSHLGQSRSFTSSHDLHNQEQQSIQQEKSSQQIHDHHDSSSSVSVNEIHPTTQFTSSSTSLSSNRSAGKNRCSSSVSSNRSSNHLSHSGLSTSLTKSATLPPLNGSNSQQQQQQMMIMMMGQQQQQHQQQQRSESDLTNASSTSSSSSINSINNNTNNTNQPMNGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I357</accession>
    <name>A0A922I357_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_004390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="771"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="1285"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1574"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1584"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1602"/>
            <end position="1616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9520697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1616" mass="185507" checksum="99805772B8188FCA" modified="2023-02-22" version="1">MATTRSMTRDLIKTAKTKVDYVHTTLLKVEEVVTGELNSDRLQQLYIQLKELRTMLVDTMAQIERWEKVGMSGLPNRDLATICLHKIADLLSEIESRAAIRASSAPIRSDDDGQRITSIFGTGSVSPRHFRRDPGISGPVTTVQAPSVETANSELFAIPKTISNTLSGTAGPSGSAQYTAGLSGSAQYTAPSFIDYMTPKVIKKLDFNFLEQPNVTFANNPEVPIMHSTINPLSAGFTFPTTSGQPQTGLDRIVMASSYRKPFNMKWADKVQKFDGKFENFHTFINAFNQFIHQTDAVDAGIDGPQYQQAYQILTKFYSASFPLQQKLKAKVEALPRAERWHQTEIMRSNLAVIKDVYNTLSTSGNNRSFLETDFFYTVAAKFPDGAVTNIMQRYGSELTISKYLNDLNSYIEQSEQQRIILCRTDYVMYLNKPKQETLLGLEVFQTGVILVNQIRLEDQRPTNVYNTPSTSNNNFSNRNVQGASRTSGTKQCFFCKGNHIPSQCPRPSGEKIRILNTLKRCVRCFSSAHMINECIHSFNCRTCNGRHNTSVCHTRDNNNNPITSMMTSEPTKLEQIKISLNDIEFEGLFDTGSTHSFISYDICDVLNMNPEPCDTLLKQAVTWTSIMGKTTLKTKIGQMTKEHQFYILPQTHYLIIGIDIIDRFKLMRKPGGKISQLVANEEIPIQAIKIKPTTSSANVIELQDFSQIKGPLKEVIRKFRTVFTNSGEIGSIRTDTCRINLLNEVPINLRPYRISQVDQKRVDDQVKLLLEKELIRPSKSNYSFPVVLVDKKDDGKKTRLCVDYRKLNDITITECYPMPLIQDIEDRMLNSTIFSTFDIASGFHHIPIEESDKYKTAFSTMTEHFEWNVMPFGLKNAPAIFQRIVYNILKHNRLTNFSHNYIDDIIVFSENYNQHMEHLKRLFAVLKDNNIILKFSKCKFGLPEVCYLGHQISFNTIRPLKSNKQAIVDFPPPKDLKSLRRFLGKIGFYQRFIPNKTELLTPLYQLLKKDQAFKWTALAETAFNKVIEVLSSDLVLHIFDPSKAVILITDASNVGIGAVLKQKDTELDDDQDMVTVGYFSRKLLPYQVNYSATEKECLAIVESIAYWHHYLYGKEFTIRTDHKPLKYINSISKPNTRILNWALRLSQYNFKIEYVPGSENVEADFLSRNPDFEVNLLTLQEISEIHANIPAIPPGCVLFNGCYVKYTGNRRRYYLPDNIAIEIVRKYHEEQGHIGQKQTALHFSQKYYNSNQNKFIQNCIQQCEICLQAKKPRRKLGLLHQLGPAVEPFSFIHIDTIGGFREAFSQLRYFHVAIDSFSRYVWGITSKTQNVNDFRQLYDKISQDGHPHYIVCDRYPALNSSSFREFLLANHTQIIYIPVTHPSSNGMIERFVQTVVERLRCKRLSMPNRSWARLAMETLVEYNSTIHTVTRYAPSFLLKGDDPDEYYEGEDLDEARSMAYERSCQDHNRNKRYYDRRRINRQFEPGDWVFAKIADELNRRKLDPRYEGPFEIITRYSSVVYGISVNNHEVIVHIENLKSANTNNRVLVPEESDEEEQNIQHEQSELEENMIARNSDVDSTPVSQIYSSTSTSITNQISSRRSQRNRHRQIRYSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3P1</accession>
    <name>A0A922I3P1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone-Lysine N-Methyltransferase ash1l</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ASH1L_1</name>
        <name evidence="9" type="ORF">DERF_004318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3P1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="145"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9520618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="305" mass="34539" checksum="1FEEC4C8CCC4B7F1" modified="2023-02-22" version="1">MNRLIEKGEFNILTTRISVKSKRQVYVKANGYEPKWMDVSSLLKKPSNVAIVNEFKSKFDAGFSTTSIDSQDPFYGLSPITRNHGNMPDETTIPLAKLCNFVTHEEGSCVSYYCENWRAGVECPINCPLGDNCSNQLMQITNNESNLKIFRTKHGNFGIKSLIPFRANEYIGEYKGEIRSINDETISSVYCMDLTENSVIDSSYFCNSLRFVNHSCMPNACSNLWAVNGQWRLAINAVRNIAAGEEITIDYGENYSTQKETCFCQSPNCAGEFKILNFQCDDNDQKIKDAKYVLENKLHETIGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4D5</accession>
    <name>A0A922I4D5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_004668</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000021">
        <property type="entry name" value="Toll receptor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001438">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1314"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="1398"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1362"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1665"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="186"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1371"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1673"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1694"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1715"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1742"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1774"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1787"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1801"/>
            <end position="1832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9520993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1832" mass="201504" checksum="6B26EDB66490D642" modified="2023-02-22" version="1">MKSKISPTKEMATSTKNQLKMSTNRHRPPDPMLSDGLLPSSSWHHHDDRQQSRNLPPLTNVDCSTTRCQINKSARMKAAKYSSLLPHSCIIPTVISLKNDSTISSLSRMMTRTKDYHDHGRNTQQSSRRFQSSSKVMWLWSILILLIVMHSCPMMMIMPNVNGVLISSNNHQSVTPAGCEWRPLRSSSSSHQQPSTSATGTGHSGSHSSMDDSSSSLSHLSIQAHSHSSTHSLSATTTMGTSSSSSSSSSSSLSSSSSTSSSANQLLQCHFRTLNGALDSGVNLSLIPGDRTHALRLQCEDLLFQSQLPERAFRSLHQLRELYIERCKLSELPAHVFIGLQELRHLTIRTYNTDWGDLSLRLSTSTSSIFSPIKNLESLDLSENGLSQLPSSILCPLNRLQYVNISANSFQDVASLGFSAKSSYEASTTSSSSSLSSSSSSASAQTATGSMKNDCRRLDSILNLDASHNRIKVLTDRGFSRLHYLQVLNLRQNLIARAEETSLAGLAELNRLDLSNNQLVALPARFFQAVKTTLAELYLQNNSISVIPPGLFSGLSQVTVLDLSNNEVTSHWIGPTTFADMSRLLSLDLSHNKLSRVDATVFRALYTLQSLSLKNNIIESLAENAFISNRNLHTLSLSGNRLQTLDAASFTGLEVLNALFLDDNRLQIVHVSSFANITSLMELNVGQNRLQTVPQAIQTLHSLRSLDLSHNQIGDISNASYRGLEQLYSLNLEDNIIGNLSRGDFLDLPSLRVLNLANNSIGSVEQGTFDNIPDLHALRLDSNKVADINGLFVNLRDLLMLNISANRIQMFDYAMIPVGLQWLDLHDNLIENLGNYFEIESELKLRTLDASHNRLVEIDSKLIPDSIELVMLNRNQIRKIAAFTFLKKDNLTRADLSDNRLATLDLNALRLSKPPPTRRPSPEFMIAGNPFVCDCNIEWLQRAALLSTPTLMLAAMPPPSTLSPSFPSLIGSDPSRQLPRVVDAHQIQCRLAFGRGQQPMMTTLAAARQSQFLCSYRSHCFALCHCCEFDACDCEMTCPDNCTCFYDQSWNTNIVDCGRNGHYLVPTRIPMDVTDLYLDGNNIAELSPHTFIGRKNLRHLYLNASHIHTINNRTFNGLKSLLVLNLADNQLDTLYGYEFERLTDLRELYLENNIISTIANRTFSALRSLQTLRLDNNRIVEFELWSMLASSLPSLQQLYLGDNAWSCDCQFVGQMMEWLPARQDIIRDLARVHCQYNESYALPLGAVAAATTMTNLYKLTEIEQARANISAACSLYAKRESIAASSSSSSSVGINGGVSVNGMTGNGTGNQIEMFIPILALIVFSTFGVLLLLASIVTAVLYRHEISVWFYARTGIRLGGGSSTGSGAKGGHGRRGRHGRGGRHGRHSDPYDADCGEKLFDAFVSYSKKDEQFVQQMLAPELEYGTSPMRLCLHYRDLPVASGFVADAIIEAMAASRRTILVISEHFLRGEWQHFEFKTAHQEALRSRARHKLILIFVGPVAGKDLDPDIRVWLKTAGNTCLQWGEKMFWEKLRYAMPEIPTASSGGGSSVNSSSSSTTSSLYGRKALQLSNNQQSKNSTLPLSLSSNQQMLNCGTNNRNFDSYQHHHQLHHPLLGGAQTTTTTLGRQQLSYGHSPMMDHPPSMAIGGHPLYSPSSIHSQQSTYAYPTYHPTGVPPPNVAPPPLPPNQLNGPPQSTPPPLPPSHPLHQRLFHNHSNGSVSGVSTSVTTMESSSGSGASGSGPLSTHQQQQLPATSTMSNIGHHFHQGSSSSTSGRHHGHHLNHPHHQQQQSASQNSNDSSLMLTSNGSDISGQSTMPFVPSASSTTAVAVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4X6</accession>
    <name>A0A922I4X6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4X6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7957" checksum="0822C7313C82CBEF" modified="2023-02-22" version="1">MYLGDRPPSPIRQDEHIMKFNEIRQHEEVAIKVTVNHRMDPKGLLKFLKDSYMVNQKPAMCPLVCRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5E8</accession>
    <name>A0A922I5E8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein fam98a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM98A</name>
        <name evidence="4" type="ORF">DERF_006080</name>
        <name evidence="3" type="ORF">HUG17_3079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM98 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5E8"/>
    <dbReference type="OrthoDB" id="512356at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018797">
        <property type="entry name" value="FAM98"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353">
        <property type="entry name" value="FAM98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31353:SF1">
        <property type="entry name" value="PROTEIN FAM98B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10239">
        <property type="entry name" value="DUF2465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7639046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9522514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="453" mass="51462" checksum="B31F4CEFA0E12E7D" modified="2023-02-22" version="1">MLMSQDLIDIFGELNCPLINDIDLDSLSLIDFARLLNWISLQLNFFSKTDSLVNLIKDESDLDSLRIELNSLLSELGSIHMNTSVDDVANRHMILHSLAGDLLAARANYVKKFDENLDVFTDRLNPKNDMQIINNCLSIPKTPNQTKDIKTYFQTVRQRLDKSPLKYQDEDSLLLPNNARLTTTQWAELKLLNEQLANEYALRREMLLRRADMTVGSFYWNREKTGDTDEKIIKQIYQEKRKGWSSKPQVTLSHALAARNSDCDSLINKRISVSHANCIIEAKQIGKANTGLQQRLQLHKFLIGAVPDRGGRPYEKPPPPKETFSQQQSQRENRGGRGGGGGHRGGRGGNRGGHDDNRRQQQTYNNTNQYNQNQNRYNDNYGGGRIQNAGWQQQQQQQQQGGYYQDNRNYDDQRGGNSYHHHHYRGGGRDGYHRGGGGGGGYHRAGGRSGGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5M4</accession>
    <name>A0A922I5M4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5M4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="161" mass="18900" checksum="831986B6A60D42BE" modified="2023-02-22" version="1">MERLEVYVQELDDNMKNVTSPLISKLFIRGRYDRQQRWNKQVVLHKSKRPFQFIIRGILNYVKTRTAIDDLSYGIECIHQRMPTRPPPTMGPITTENPPYIHNSHHHGVGSIVAGIMIPIFLLIGIMFGYYRYRSSYRHDQSNRTFVTMFISSKDSVQLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I696</accession>
    <name>A0A922I696_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SLC6A1_1</name>
        <name evidence="14" type="ORF">DERF_006453</name>
        <name evidence="13" type="ORF">HUG17_2838</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I696"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005332">
        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11496">
        <property type="entry name" value="SLC6sbd-TauT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF265">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="13"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7638805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9522901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="643" mass="72624" checksum="8F745D9D649C14A2" modified="2023-02-22" version="1">MAGNKVEMNSFDGNTGGMGIHQSNNATTSGIGGGRTNASGQHSLTSGTAGGGGGGVATEVKLTNTKNIPERGQWTGQLDFLMSCIGYAIGLGNVWRFPYLCYKNGGGAFLVPYLCCLIFAGVPAFFLEASLGQWLGIGGLGVWRICPVFKGVGYAAAVMAFWLNVYYIVVLAWALYYFSQAIDVDVPWKGCNNWWNTERCRSEYDLADEERRCYIERGPQDFTCKMNTSLFTSPVKEYWENNVLQITTGMDDFGEIRWPLALTLFITWAACYFAIFKGVKWTGKLVYFTSVFPYVCLFILLLRGITLDGAWEGIRYYLTPNLSKLTDAGVWNDAATQIFFSYGLGLGAWIALGSYNRYHNNVHRDALIISCVNSGTSMFAGFVVFSIIGFMAKAQNKPVEDVATSGSGLVFLAYPSATLKLPFSPLWSMLFFMMIVMLGLDSQFCTMEGFFTAIIDEWAHILRPHKEMFIMFVCLVSYFIGIIFVVKGGMYWFQLFDYYAASGFALLFLIFFEVVAISWSYGVNRYYGNLSQMLKFPLPIWWKLCWFFFTPSVCFLVFCFSLYQYKPLKYMNYEYPWWGQAIGWFLALSSMVCIPGYAIYLYIVTPGTFSERMKALFRPDIPEIEDEIRRRSQDDIDTSVTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I789</accession>
    <name>A0A922I789_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ionotropic glutamate receptor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_005610</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I789"/>
    <dbReference type="OrthoDB" id="6497895at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037940868" description="Ionotropic glutamate receptor C-terminal domain-containing protein" evidence="13">
        <location>
            <begin position="25"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="33"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9522006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="348" mass="40295" checksum="0F94CC304745C569" modified="2023-02-22" version="1">MPPYSSIILIFIAIAMMTNMSIWAQPANQNRPTLRGLTTLRPPFVEKDLNGKLTGYFVDLLNEMAQIGNFNYTLTDSVNQDSTNDGFQSRPTGLINEVFRNRVDFAIADYLYRTASQQRYVDFSDSYMESNLSALIHKDRIIQNNIKTIDDLLDQRSKPPAVIPVVNQQQQSYQSQQSNQQQQQQPEEIIQLGTVRQIYRDLSVGTDPLSRRIYEQLHNNPGNMAENRQIGIERAMKTPYAFIQESINNELAMDENCELKHIKLESTNFPMADTHYEYGIIGQKYSTHLEIMNRAIRELKANGRLDELKRRYWNRKCNGGVNSFEQYRYMLTVVTTLFSLFLSLFILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7E4</accession>
    <name>A0A922I7E4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7E4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7414" checksum="541EBAA8C89B894C" modified="2023-02-22" version="1">MCYLIVESQTGLNQYSHNQASAIVVIDEGFKMIREVLNKNGLELNVSVLIINDDLDAAVQAVQTCFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I809</accession>
    <name>A0A922I809_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_005954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I809"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="541"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="570"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9522375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="828" mass="94235" checksum="33668886618FE750" modified="2023-02-22" version="1" fragment="single">PPKCAFKSPSTKNPSSSTTTMSLSSTTTSTHVTKIDSVINYPANLFCQVDATMPSSSSSSMMIDDRLWIYWQLPNNHYILTIDHHGKLLRIPMKRFDQFRKLREKFSPPILSSYTNDDENRLFDEQVADLLDLHDLNDDDNNNDNVGYDEQQQPDINDYRRITLASNDVRSRLTIIPRSNIDFGLYQCWAENIFGSNRYEPCLFNLTNNDFDVDGNQQQRNHQKSVWKNTTTNIRNVLKQKSKLPHPVTNCTTTFLIASLLSIRCRHYNYSSYSSIFHRTTTKINHQSSIGHEVDTDDDDIADRNLQFHLILKELSSSHDSNQLKKDMKTRISKNRWPIFISNQSNPIEPIFLLSNLRANSVYEAIIYVSNDFGFSDQTRIIIKMTANTTTTKTLKMSKTSGMNGFYSNDVDDYNHHNTFEWPSPYSPSLSSYDDWPDMNSFDYPEYDDADGDDDVDDDSLISSPSMTMGKADLHQQQNSHHNPFNGPFSTTVSLSSSSNHHHDKHHHHHNDHHSNIDDDILNNEFGLGIGQNSTTSQNRFVLIIIIIFTIVLIAFSTLLSIAIGLCLYRRKRNKLIELHQRQLQEQQQQQQQQNQSLFDQGKLNDNFSDDDDGNCNNGSDNENKIDGEKARILDSGFTETFPLDDYSTGVFILDTTRSNTSNNNNHHHPTDSILSNNPIHHHYQQQPTRHQMMIYRDFVSSPPSSSTSPATSMIQQQTTTMNLLNPLIQQQQQQQPPMTTEFLYQPATPGTSGFLDLAVDRGNVQLIPSSTSPPLPQSSMASYLTFSNIEQQQSGTTSPSLMLTTTDTATFSNNLAGINHHQSISEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8W5</accession>
    <name>A0A922I8W5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8W5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037825159" evidence="2">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="167" mass="20322" checksum="B453DBE041DC0B82" modified="2023-02-22" version="1">MFNNHYLLIVPLLILVIAATVDLRPPRDYGQILPAEKHNVTTTTSRPNRHRDRNQNNKNNDRDRYNNNNDRDRYNNNNDRDRYNNNNRNRNQNQDGNPQSYSSGDSYGDNSYSSPSSYDSYGNNNSYNNDRNDNRNRDRNERKREREERRDERKREREERRQQRRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I950</accession>
    <name>A0A922I950_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PGM1</name>
        <name evidence="18" type="ORF">DERF_006514</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I950"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="13"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="193"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="326"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9522960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="563" mass="61678" checksum="B950B97CA537BB1F" modified="2023-02-22" version="1">MIKVVETKPFEGQKPGTSGLRKPVQTFQQPGYLENFIQSILDVSLADVKNRNAVQLVVGGDGRYYSSQAIQTIISMCAANEVGHLIVAHNGIMSTPAISAVIRARNAHGGIILTASHNPGGINGDFGVKYNCANGGPAPDQVTNEIYARSKQIKQYKRLDPSMPDVDVGRIGQHVVKHSGGEMMVDVVDSVDMYLNLLKAIFDFELLRKFVSSKRLLIDAMNGVMGPYVRRIIVQELGASADAAIRCDPLPDFGGHHPDPNLTYAADLVDKMRNGPYDLGAAFDGDGDRNMILGAKGFFVTPSDSLAVLGENLERIPYFRRDRVKGYARSMPTSRAMDQVAKKTGLKCYETPTGWKYFGSLLDAGLVSICGEESFGTGSDHIREKDGLWAVLAWLSVMATMPDDQSNSVESIVRQHWRTYGRCYYCRYDYENCDARSCETMMSTLAAKIAANQLPKTIESDGTTYHVDEAFNFGYTDPVSGEQASNQGLVIQFNGGASRVMFRLSGTGSTGATVRLYIEQMEMDAEKAINGNQEDYIRPLAKVALQLSCLSEFTGRQQPTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I959</accession>
    <name>A0A922I959_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I959"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="80" mass="9280" checksum="31ECAF527E434BC0" modified="2023-02-22" version="1">MHALDDEVAKFFISTKIISTFTNLCYNLKMVMVLKTGHHAMMMSMNLVNHTVIYCHYYSGCLWLFSLFLLLTFLAGHIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9D6</accession>
    <name>A0A922I9D6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="9">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">IMPA1</name>
        <name evidence="11" type="ORF">DERF_001821</name>
        <name evidence="10" type="ORF">HUG17_6829</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="9"/>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9D6"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020552">
        <property type="entry name" value="Inositol_monoPase_Li-sen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00378">
        <property type="entry name" value="LIIMPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7636623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9527827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="286" mass="31711" checksum="57D2153C84CB9523" modified="2023-02-22" version="1">MSSSSSLLKEYLDFAINLARQAGQKLIQWQTNGFDVMEKGIHFGSMKDLVTDADAGIENFIFTQLRHRFPDHDFLGEESDGNQMNCLESNRPTWIVDPIDGTTNFTHLFPWSCVSISLAIDQEIVLGVTYCTGQERLYHAIKNGGAFCNGYPIRVSSNVEKLSEAMIQTGIPIGYTPAEFPVNFSSDLFNTIIWPSKAFRCVGSCCMALCMVADGSIDASFMIKIKIWDMVAGYIIIKEAGGYVFNIHGDKFDPNGGNILATGNLELANKIGKLFRKCSQGIIYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9F6</accession>
    <name>A0A922I9F6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000173</name>
        <name evidence="2" type="ORF">HUG17_8029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9F6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7640560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="137" mass="16220" checksum="FAB6C6288FB1BF3E" modified="2023-02-22" version="1">MFYINSIESYLDSFQRKIQQFRHWLLHSRWALLAAFIICSFIIICSIIIVWSIVEQKNFQKAEQDEIMLITSETTTTARRRILEHTTQMFMTTEFDLNNNHFDIKKLCDNLCKHDPELGGQLCDCDEPPMNGYHAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB80</accession>
    <name>A0A922IB80_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ACP7_1</name>
        <name evidence="6" type="ORF">DERF_001604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB80"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038164424" description="Purple acid phosphatase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="5">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="129"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9527597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="379" mass="43720" checksum="4F3B3ECF8E2EF13A" modified="2023-02-22" version="1">MFQLKFLIVCFAFTKLSFAYQEYLSHGPEQVHISYGAGPSQMYVTWLTHEQPSGPPVVEYGIQSGKYELKKHGNMTKFTTAYSRYIYRVALEDLKPNTTYYYRCGFEQELSNEFNFRTRPQDQENWSPRIAVYGDMGLVNGQSFPFLKQQVSKNAYDAIFHVGDIAYDMHSGNGLYGDLFMREIEPIAANVAYQVVVGNHENDGYNFTDYDGRFTMIDENSGKMNNMFYSFNIGPAHVIGFSSEFYYYTEYGVSQIHNQFEWLEQDLIEANKPENRAKHPWIITMAHRPMYCSTADDDDCTENESILRKGIPIVNAYGLEDLFYKYGVDIIFGAHEHTYERLFPVYNRKVYNGSNNDAYDRPKAPVHVLVGSAGCARKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBF6</accession>
    <name>A0A922IBF6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBF6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="35265" checksum="2260A3045CA3C0E9" modified="2023-02-22" version="1">MSTNSSGSSSGSTSQKIVKSNRSPIGNRNNRNYHRNRFQNNNPNNQMAQIKELLHLIPFAAQFFGNNNDNNENAERIRILDERLYNEQQQNASLVRQNLAAGSLAMVQDGEIKNLNRINDQFIHDNDNLHEDQRIDRQYIRQLQSNEQTFRMWATIFSVLFIGLAFYYWNQTNQMQQDTRRQIEIENKFAQLTGLIRNDKHYHKEQKFLEIIKQREQEIQMLRNRRHKSDKMTEAKNRHVIHQNDNDFEHQNYDDDTMNIDDDDDDMINRNIEQIQADVIDQIEKELNKMRNKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC84</accession>
    <name>A0A922IC84_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Embryonic skeletal limb joint morphogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OSR2</name>
        <name evidence="13" type="ORF">DERF_000157</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Odd C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC84"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000090">
        <property type="entry name" value="Odd-skipped-related transciption factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000294">
        <property type="entry name" value="Odd-skipped-related transciption factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000318">
        <property type="entry name" value="Odd-skipped-related transciption factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000311">
        <property type="entry name" value="protein odd-skipped-related 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF0">
        <property type="entry name" value="PROTEIN BOWEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="147"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9526038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="466" mass="53461" checksum="680324A488824C95" modified="2023-02-22" version="1">MINDTNIMDRSMINMKNHQISSSSSSTSQSSSLANMILLQHYLLAQRQQQQSIDKLLSHPIQHQQQSVEILNHLHPQQSTNLYSSLLMASFNNHIHNHNHHQNHHHDHHNHETNQCQSHHLVASMNPFTSSYPHMMTAAAMFNHHHHHKQSLMETTSSNLLLTPPHTPGASSMENGSSSSSSVSAMSPPPLNLTKIKQNPDKQSQLHTEPMKKRKFDFANLAKSATEPDNDDDVLYSKINTNQQIKNLNCDQFTGENGERKIANNSNGGKRKKKKFICRFCQRQFTKSYNLLIHERTHTDERPFNCDICGKAFRRQDHLRDHRFIHSKEKPFKCTECGKGFCQSRTLAVHKILHKEMSPHKCHLCGRGFNQRSNLKTHLLTHTDIKPFNCDKCGKEFRRNCDLRRHMLIHSMSNTIQCQQLLLDGQKSLIKTTTTTGTTTTSNQSQSQPSTIHQYNSIESLVARNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICP9</accession>
    <name>A0A922ICP9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="6">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ACSL4_2</name>
        <name evidence="10" type="ORF">DERF_001903</name>
        <name evidence="9" type="ORF">HUG17_6878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="6"/>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICP9"/>
    <dbReference type="OrthoDB" id="6495156at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="127"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7636672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9527916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="744" mass="86252" checksum="40D1BEBB679D46A4" modified="2023-02-22" version="1">MWKRLQYLWKKVLPQQVIRIVILCIATVTVVFDIITLPIYLLWHKPWRLWHLIYRNRSLQDVDYPDDLVRKSTRTHLPEFYLDDCQTLDEAFEKGYEIFGPQHSCLAWRPILQRESNKQNDINIPYRYKLGEYQWMTWKTLIDSINQFGSALRRMLSAQKGDRIVIYAETSYRWFISAQAIIKNGSVVATLYPTLDNQGVYDAIKECETTIIVTTNQLLKKLIEHPRKSEIFQQLRYLIVLDQKEGQYESNKDIERFNLELNNNNQNDVQIITYEQMLQAGEKNFNFTKNDPDDLAVIMYTSGSGGRPKGVLMTQRNIIGLFKGCIGLLEFFLHETCRHVYIAYLPLAHILEFGVETFVILLGARIGYSSPHTLTDLSAALMPGCKGDATLLRPTVMACVPLVLDRIRKTILTRLNQRGLLAVKLFEFIVEYKYFWMAKGFQTPLLDHIFLRKFNELLGGNLIGMLSGGAPLAPDTQKLIRACMNIIFIQGYGSTETVGGGLFMDTHDYSLGKVGGPQFGTKIKLVDWTEGGYTITDKPNPRGEIHLSCESLSIGYFKLKDVDRKAYYEDHLGIRWFRTGDVGEMFPNGSFKIIDRKKDFTKLQFGEYISLGKVETKLKTSYLINQICVLADSMRDHLIAIVIPNQKAIERIWTRQIANKCQNNERENLNLNNQKLLQIFRKKMIIHARLNGLRRYEIPKHYLLVQDEWTAENGLVTASFKLKRKQIQHFYQEMIEQIIVENCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDZ9</accession>
    <name>A0A922IDZ9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase neurl1b</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Neuralized-like protein 4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NEURL1B</name>
        <name evidence="9" type="ORF">DERF_002241</name>
        <name evidence="8" type="ORF">HUG17_10207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDZ9"/>
    <dbReference type="OrthoDB" id="6078042at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16647">
        <property type="entry name" value="mRING-HC-C3HC5_NEU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000005">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase NEURL1B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF6">
        <property type="entry name" value="PROTEIN NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NHR" evidence="7">
        <location>
            <begin position="31"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="7">
        <location>
            <begin position="235"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="545"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7636237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9528285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="596" mass="68308" checksum="00EC2BA26E1BE4C6" modified="2023-02-22" version="1">MKLLKKIRRIASQKNLSCTTQQQIATNNLTPIGFHSVHGENIRITGNGMIAERVGSYCRGICFSNRPVRYNEHISIRIVEMSDFWSGVLRFGFTTKDPSTLRNSLPKYACPNLTNCGHTFAKALPERYSHKNCILSFYLSTNGNVHYSINNVDKGIILENVKINNGPFWAVIDLYGNTQKIELIDPRYQPNNSCNKNMYIEPERLYTSVSMMDLPNEMSHEPSPQIYSNKFLEQSIQFHRTRGCNVRLSSNKCVAERNSNHYSQGYVFTQRPLAIGEKIVLQILRTDEMFTGSLAFGLTSCNPNFLNVADLPEDSHHLLDRPEYWTVIKDVANSPMAGDEIAFTITESGEVIMTKNRQRPITLMHVDISQNLWGFFDLYGSTIKVRLLGSQTINHHKSQMNLANHHSIQSNRPLMNAISMYNVYKSSQMEYSIALNHNHNHNHHHHNQHQSYHTKQKPTIMTTQQQQQQNWPYVTYPTIQRENKANANKKAYHQHNYNYKNNDYHHVDGKLYNQISKSLTNSTSLSSSSSSSTTSSPSTTFGNECVVCYEEPINSVFYTCGHVCMCFKCSVKQWQTSGHCPICRAKIVDVIRTYWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE25</accession>
    <name>A0A922IE25_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE25"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="7294" checksum="EA565FD89AE3F2DC" modified="2023-02-22" version="1">MKTPKIYLYGYSIFKFIYHANDSCPDYNDGHHRHHLNNDQMQINCQKQKQKTLHLLIMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE31</accession>
    <name>A0A922IE31_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE31"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="119" mass="13709" checksum="A8859E4A4B9265C1" modified="2023-02-22" version="1">MANQKSEQHSKAGIQFYFLAIVVIVSNQTTLLKRTNTLILKDKISMNETPKLIDRIHIDTSTPGSMALITGYEMIHLFRILNHEFNSFDQTKIYQAITEQLIDINMASVPKLFFDNLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IED0</accession>
    <name>A0A922IED0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SPF27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BCAS2</name>
        <name evidence="9" type="ORF">DERF_003765</name>
        <name evidence="8" type="ORF">HUG17_5642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IED0"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7642595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9529909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="217" mass="25663" checksum="BFA91CEEC9D33DE3" modified="2023-02-22" version="1">MYSDLVDALPYIDNEFNNSEVRLAVAQMVEDETKRYRPTKNYLESLPNLPTLDVNKFETDILRKEFERLNNGQSMEQLNMKRYELPSPSTGKLNDIWAWQECLENSFTQLEHQTIRIQNLELLTEYGTETSKMYNSIMTQLLARSKAHLEKIRKQIQDINLLRKNSQTQAGEQIKILEENWVSLVGKNYEIERACLQLETDLIKLQQQQKQNFQQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IET6</accession>
    <name>A0A922IET6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Phosphatidylserine synthase</fullName>
            <ecNumber evidence="22">2.7.8.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Serine-exchange enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">PTDSS2</name>
        <name evidence="24" type="ORF">DERF_003766</name>
        <name evidence="23" type="ORF">HUG17_5643</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">JKM2019</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="22">Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:41496"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:78263"/>
            <dbReference type="ChEBI" id="CHEBI:78264"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:41497"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:41604"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:78342"/>
            <dbReference type="ChEBI" id="CHEBI:78343"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:41600"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:78340"/>
            <dbReference type="ChEBI" id="CHEBI:78341"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41601"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:41488"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:78261"/>
            <dbReference type="ChEBI" id="CHEBI:78262"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:41489"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:41484"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:73007"/>
            <dbReference type="ChEBI" id="CHEBI:75029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41485"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:41492"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:78265"/>
            <dbReference type="ChEBI" id="CHEBI:78266"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:41493"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:41500"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:78268"/>
            <dbReference type="ChEBI" id="CHEBI:78269"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41501"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:40795"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:75038"/>
            <dbReference type="ChEBI" id="CHEBI:78260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:40796"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:27606"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 22">Phospholipid metabolism; phosphatidylserine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Endoplasmic reticulum membrane</location>
            <topology evidence="1 22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the phosphatidyl serine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.29" evidence="22"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IET6"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF7">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 22" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 22" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 22" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 22" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13 22" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU368094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH7642596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAH9529910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="475" mass="55961" checksum="D458FD7676E1452D" modified="2023-02-22" version="1">MSQTKSSPSILFSLNSNTNIRYEEFDEETKTDSNDGSKKLITAHDWQSYNTQDVFDDGTQTFFWRAHTLTVLFFMLTGLVYVALVEKPSLDTNYNVKRGLVAVVLVFIFFGITQIPDGPFIRPHPALWRLVLCLTIIYELSLIYILFQTPDDARKLLTHIDPSLGKPLMEKDYGGNCRIYDKDKPDDPFHNVKDKLDIFVPTHFFGWWLKTLMIRDWWLCTVISIMFELLEYTLEHQLPNFSECWWDHWILDALICNGSGIYLGMLSLKYLYMKPYDWRGLWNIPTYRGKLKRIVAQFGPHSWLQFDWRPFSSFDRWIATLLLIITMLVAELNTFYLKYVLWLEPPHALNLMRLILLVFSGAVALRETFQYLDDPDCTKFGRQSWVLIAIIITELLIILKFDFEVITKPLPKHVLYSWIGAIIILTVWTFWRFLLKNTIQFMYQNRKPNVVIKSNNVNVIDSTTKRKNPRIKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEV0</accession>
    <name>A0A922IEV0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEV0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037080309" evidence="2">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9530236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="193" mass="22076" checksum="B9350D289DFC53FC" modified="2023-02-22" version="1">MAILSSLLFLLIISPYCSSLPYSSSSSSSASSSSSSSKSHRLRGLSSRTAAYPTRTISSRYYQTSNSSISSLHQPPMNHNQITQSTSSSSKVHGAVDCIMAIHNEISWCNQSYHQSLTQAIIKGYRKESRVYRRQYCCGHWSLQRCIFTVMQRKCDQETYDKIRDARSMEWNTQQQNQQINCDDYEHNSPIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF14</accession>
    <name>A0A922IF14_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF14"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="6987" checksum="D642F03F23F8C02E" modified="2023-02-22" version="1">MAYGYCCFFILFFFGLMSDQTLNIKRVACFVYTLVKIVITMVLGPGGGYFGPPFFAGNRYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG51</accession>
    <name>A0A922IG51_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NAA40</name>
        <name evidence="14" type="ORF">DERF_003975</name>
        <name evidence="13" type="ORF">HUG17_5814</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG51"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="69"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7642767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9530151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="222" mass="26117" checksum="AFABE72CA93BFA7E" modified="2023-02-22" version="1">MGKKSSSKATIPNELLLRMANEFENPLAKFDDDYDSIEQCLSTTICDLRIETRYFMWTKLSPELQQWMIDLTEENMKDLYDSCSWKWQRKSKLGELKHSTAKHLIIFHKPTVDSSPPSKPIAFVHFRFEQGYVSDAVLYCYELQVEQSYQHKGFGRYLMNLLELMAKKFRMQKVIVTVLKNNNQATQFYSNGLQFKIDKNSPSYFQQEADYEILSKRVSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGC1</accession>
    <name>A0A922IGC1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger CCCH-type with G patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_003041</name>
        <name evidence="16" type="ORF">HUG17_5061</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAH7642016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAH9529139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5842926at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Znf_CCCH"/>
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    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="15">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004062"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH7642016.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9529139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="502" mass="58884" checksum="BDABAAE7ED4919B5" modified="2023-02-22" version="1">MSNQVHNVDDNESNIRQELQEHLAQLKAIKEQQQLDDNEELGILKSNLEELCRLLEDELLSIEKRKLLKDLNIEDDDEKIEKEKPPSINTEIDDNPLNQFECSVPYRFQNGHIEYHDALVIVEDDENNGEHEHKVRLKAFFLYPVEKSMQTCPFYLRDCCRFQDNCKSSHGFPIASIDQVRSKVSINLFSDEDIDSSKLGQLKNCLVQDHEENIWQKAEITDTDLNKERILVRINKDKSEKWIHFESLVLLQNVEPENSHEELTTGSSNQSMDFQIPDLTCTEFGEWERYTKGIGSKLMAKMGYEQGRGLGRQSQGIINPIEQIVYPPGRSLDHCIKLKQEHERKKQDWREILKEKNKKLKFEAKLSDQYDRIEKQKGRAKSMFEFLNNRLNQIHASTESKSPLANNRSFKNLDQRSLNIASFKSEQDLQRAQVELDKMQRMRSRHYVSNQSNVDQNAVLMKNDYESSIERQQNIVSRLRIENEAIKKEIKSRSERSKLINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KS94</accession>
    <name>A0A922KS94_DERFA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <end position="229"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
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    </feature>
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            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9493318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="442" mass="50263" checksum="8053D1A6A570CC5B" modified="2023-02-22" version="1">MWLSIVTDHDPIIGHRDDDNDHHHHIQIMTRSRINYNKQNQNMNINQHNNNNDKKQIHHLIYNDNNNDNDDDDGNDDQGKTRAAIDELNEVLRNIFPVVPYQQNHHNHHNGHNNYNNNENNDYYYHPHQQQQQRKQKHFVWSRGGGLFFQPPPPPPPPPSSSSLSSLSSNLDSMNKHHRHYQSSSTPWFSNTDPINNDEDISSSIDSNSVDNNNNFDSENNPDNNDMASSIKKSNQIVFMDTTNTIDTNNQQLSPLPSSSASSINIYFNGKYGSFKYNGSTTTATATQQQQSVNTIPLSSSSSSISASTRASPSPSSSVLNIESMDNKNDNDDNNNNQNNDESTILKDPNRLIELLRRHLQQFPRERLLLQKQQQQREQNRQKLYSIHQHKPSILSSSSSSILRSSPSSSSSSTTLGKRGPECMRRCILQGLLHPVQCHSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVN5</accession>
    <name>A0A922KVN5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Acariformes</taxon>
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            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9496964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVN5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9496964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="147" mass="17060" checksum="5674A416DEB245E3" modified="2023-02-22" version="1">MPILAIFGNFGPILPTNRWMKRSGGETWNMMLRENYIAKNIFMIIVSKNYITSLIYSKTSLNCADLMFNFVIDVVPTRRPYDSVEQYLHKRRGIQCMINKATVVFIIALLVVVIEAKFNEINIMSDDEITNYTNHQDWSEMLPTTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KWM2</accession>
    <name>A0A922KWM2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KWM2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="77" mass="7953" checksum="476B1CBD88319277" modified="2023-02-22" version="1">MNEFGMARVRLQNNSLADCNIIAGVAIGGMTRAELNNNAVGIGPTEAAASLPSIGRSLTKLWPLQAMISSSPTIVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KWQ6</accession>
    <name>A0A922KWQ6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_013626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KWQ6"/>
    <dbReference type="OrthoDB" id="8177818at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037411546" evidence="2">
        <location>
            <begin position="36"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="161" mass="18008" checksum="ECC9A702DB0D1D8C" modified="2023-02-22" version="1">MYVIQHIMPSSSMNCNYILLSCIILLAMIIAPVRSLKCFICHTNDNEHCKLQDCPVDQAYDRCMTTLYKNPTDGLNIKKECALAPCHLRGLKQLNFANFKSNCESSKQDDCIYCCTEDGCNKDSAIKLMANATYIINVIIICLIVSLLSSFLSTTTSTMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KXA5</accession>
    <name>A0A922KXA5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-spondin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SPON1</name>
        <name evidence="16" type="ORF">DERF_014699</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KXA5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2130:FF:000002">
        <property type="entry name" value="Putative Spondin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000019">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2130">
        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF16">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Reelin" evidence="14">
        <location>
            <begin position="52"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="15">
        <location>
            <begin position="232"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="685"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9493975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="889" mass="99849" checksum="6F9C9D07C03B320F" modified="2023-02-22" version="1">MIMKESNSFNRDNDDDDDDDEFIFRISFVCQCLDAILSYLSDFGGNSLNNVNVVLQGDQHRPSKYSVPGGSTIYGPSSSSSGGNSQRFTEFVLYVVPKDFSSSSSSSSSQSSLSSSNLNRWTSSSSSSSSSVSPSSTQQRSLLDVGSFQPQVYTDSLVKLSKDCPNAVTHTSPVPKNEISVMWLAPQQGSGCIVFKAIVAENKDRWYHEDGGLTKVLCEEEADTIADAESEIVDECCACDEAKYEVTFEGYWSKYTHPKDFPANAWQTHFSDIIGASHSSDFRIWEYGGYASEGVKQVAESGITKKLESELKAESSKIRTIIKARGLWYPNLNGKTFAVFRVDNRHHLMSLLSMLGPSPDWFIGVSALELCLKNCSWVADKSINLYLWDAGTDSGVTYLSRDLPTIPQERIRRITSTSPNLPESPFYDPSGAPMKPFARLTISRQRIYEKVCGDDDNRFSISDFDDDDNRSTDCSVTEWTVFGPCSVACGHGIRKRTRNYMNETRAKEVGCNMKLIETEECGAKCVNNVSCETTAWSEWTSCNVTCGRGYRKRNRKFLHRLARNLCQNVELEQRESCVGTLSNCGHQNQHQSSSSSSSSLSSTSTGSSTGHNNYDQEIIEPHCAVTSWSEWTPCSVECGKGVKYRNRLYINAYKSKNVCNVKLIQVIECFNKACITHNNDAQHVCSLSKEVGPCRGYFPRYYYDSSKGACLQFIYRGCRGNHNNFERLQDCKEKCENQFKGFIDENIRSNTNVQMYNQYNHSMTSPLIGDDQNLVIDCVVTVWSEWSQCTKPCGKARKERRREIKLNPQNGGRKCPKLVQRRKCKENPPCECAMSQWSEWSSCEAHCDTGNGLKHRHRNITQYPDPGRPTCGATVERQYCVDYPTPCNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KXJ6</accession>
    <name>A0A922KXJ6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KXJ6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7580" checksum="0210C5034C43C881" modified="2023-02-22" version="1">MSKLNNLEQFGRKVEYVYGGVPIVFHSHWFADKMTSSSSSSTIWLFLQLTYVTQVPCTNKHHHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY96</accession>
    <name>A0A922KY96_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">triacylglycerol lipase</fullName>
            <ecNumber evidence="1">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PNPLA2_1</name>
        <name evidence="8" type="ORF">DERF_010581</name>
        <name evidence="7" type="ORF">HUG17_9762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY96"/>
    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000003">
        <property type="entry name" value="Patatin-like phospholipase domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF41">
        <property type="entry name" value="BRUMMER, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="12"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="664"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="45"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7643071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9505810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="725" mass="82878" checksum="7A9427AA30511083" modified="2023-02-22" version="1">MEKLDPTKPISFSFSGCGFMGLYHVGVASCLREYAPISPDTKFLGASAGSLAAISLVCDMPLGESTSEILNVAMRARARALGPFHPSFDINRILYDLLMRTLPDDAHIRANGRMYISVTRVSDGKNVIINQFKSKEELIKALQCSCFIPLWSGLLPPKFNGITYIDGGCTNNLPILDENTITVSPFSGESDICPQDDTFNLFQFNFTNTSISISPSNIYRISRILFPAHPETLSKICQQGFDDALRYLQRNNKISCTRCLAIHFTLEKEETSNKHHRHHKHHANCRDCEYRRQIAILDSLPESVVEAIQEACDQVNKGIINWLFRHRPMKLLSILSIPYLLPIDITIVLFSKIYEKLPDIQKELKESFMRFISLLKSLLVKIESNRYFYSAKFSCQLAVKEFDYTSEENLTKIRKSSSHSKSLFMNDIAKQQQQQQLQLQQQQQQQKIMINNQPLKESKSLDLKKLDPIKYRKASYAGREVNQNRNKPRRRSMIEMGSHPDLPPERVISQLNFDLKLDVKPDQSNVKTTMDTRNNNNDVIDDDIDGPSSSLDSKVIDIDINEIDQNNAIEIANKALNWEKEILEKCHDHLNANDGNFDRMLQITKNNDAVMAYYYTDENNKVQFTELFKIGDEDIDKLNDKENNNNNDDDPNIIDNYQQQIPTYKKDNDDGLIESTIPHGNIQQQQQHQHQTTTTTLNDKNNGSNGGNESPKKRPRKLSSIIMVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZV5</accession>
    <name>A0A922KZV5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MTP large subunit lipid-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_012199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZV5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005548">
        <property type="term" value="F:phospholipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045811">
        <property type="entry name" value="MTP_lip-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039988">
        <property type="entry name" value="MTTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13024:SF0">
        <property type="entry name" value="MICROSOMAL TRIACYLGLYCEROL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13024">
        <property type="entry name" value="MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN, LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19444">
        <property type="entry name" value="MTP_lip_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037873923" description="MTP large subunit lipid-binding domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="MTP large subunit lipid-binding" evidence="7">
        <location>
            <begin position="714"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9501346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1037" mass="118293" checksum="40444130070D828B" modified="2023-02-22" version="1">MFRQSSIMWTLLLILIYPFTLLITNVNLHPAPSSLCHGSLPGIQYQYEYHSNIILNNNDNLEPAGFRVKGQVILENVWQDKRSYLALIELRQFKFEPRESSSSTRFFDTNAENVDHNWPPVLVHINGHDGHLQNLFVEKSHDNHHHLIEPTQLNLIVSIMNALRNRRDQKSDNQILPYEWELQGRHLIRRKSVQSELMEDFGKYSLLAPLITDNWEIESELAIDHDISEHVKGWQNVTLESKIYPNAHSKLFVNFELKLISQHSSAIVSTLSKAQSISQAVYLFGHHVRSKSMASLGPSHFQAERKPCQPHFCQSLSEFIQEYKRSLAEDHSLATNSMSVAFLRLLNYIRINSHKISRKDVAKLLQQLEKSRRNDDNIWSTLMDTIAASRHGDAMLAALDHLNLPKCQGDDRVGDCERFLVVTAISGSTVANMGSSYVAEHSLSVEQLLDLFVPLLSNGSWADHRVRNSFAMTVATLLHSYRTYVKTLSHDNFNNQSIIADHIPYESSRMTLRHHSSPTQFVDVSPESNAKDDKPDLKSQNHDRRHHQQKLLQISEKIIKQLQRDLDSCKDVECRIVYLHALGNTRIISKFGMLNTLKRYVINGGKRESVAAMRAMRDCVETEFESNAFDMNEKLSIRLRQLLVRILYDSNLETTTRLIASELLANVVDRDGDITIELIKHLDKFPSELATMIWKRAVQNVLLKRRQNRLPGVKSENWHLHSKILSGSSASFRYVMGGTGYANASYGVFLELLKGKLPKETSFNVDISRDNQMYQDIINVGLFARGLQSFAGESDDGDEDDELSAKSSSDDEESTMAGMTLHVLGQQLRPLIFFRSTSELMGHVWSGTGSEPTSVFRANLLLADYLDVKPLINGFLVEQTLKGVFSIDLNGEIQISIWNRNSHSNVQTKGAILFQGSQEIYAATDRTKTSAKKMFSFGAEAQLNFITDFDFYSSPYRICIQITQPEFIFRHNTRKYEQVHSDHLHRRIHRRSYKIPAKSYMLNRDNSEMCAMMNGNDNNGGINGGNGGQEDNFFSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L125</accession>
    <name>A0A922L125_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L125"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="131" mass="14738" checksum="BE70E15C17F620F3" modified="2023-02-22" version="1">MLKQSSIHRQQKYETSSSSSSLVKTKLNDDDDDDDDDNDYDSMATKIQSKVIVVNKNYVNETDVIDHSNQTNTTTKATGVFNNDIYSSSKENSKHHDESDRLLIDFDPNLNNKFPSSSSSMIATTLLLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L148</accession>
    <name>A0A922L148_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoside transmembrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ent-3_3</name>
        <name evidence="8" type="ORF">DERF_013985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L148"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF80">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9498062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="465" mass="53335" checksum="87FB672F60DF394C" modified="2023-02-22" version="1">MNANNNRHYYPLDKWHLIKIVFILHGISALLPWNMLINADSYFVDYKLVRPNQTTTAPFSLDNVDAGLNITEIIHSDLLENYRQNFLPYLSTDPLVIDITHSFIASSLNSSPRSYRIRMNVSFLVQIALFIIMIGLAFIDTSEWPVVFFWITMIIAVLFNTVNGIFQSCIYGFVAKFPMKYINFVTFGFSFSGTIASIFLIVSLMLSPHPRTVALYYFSFATAFMILCYVNEIFLTKNRFFRYYFYGHANQKLAAHDNPLQVQAKNGDLQMDNVNNIIQHENEKNEKMTIKTFKLVWNKCWIQLMNSVLIYFSTFVIFPAIQAAIKPLDSIVEQKFFAPVFCFLFFNTFASIGNYVAERIRRPEPAGLIYLVAIRFLFIPFFLFCNYIPDRRTWPVLIQSDYVYILGSASLAFSNGYASSLAMMYAPKCVPQQYAPISGMMASAAVIIGIIIGVQCSMLFQALIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1I2</accession>
    <name>A0A922L1I2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_011313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1I2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="695"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="96"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9506587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="799" mass="93778" checksum="D17456F2D9E1A691" modified="2023-02-22" version="1">MIHLNLIDKHYVSMDHKYRYYYHHESGFRFRFRFYILLLISLTLPQYCSTNDAIIINHSEFLWRPLFNVSNDFFAQAILPITFIDNQKFFSQNNLTSTCQNDLRKAIESTLHLREIWSIKLFNSWSKSVIPAGMFMGTLTDYGDYDQCMSIIDDQKSNQSLIIPQYCLIDMAIPMPKPRPTPHNYHHHTEGILPTKDFLDKIIELDLIGHHNSSSSTIIKQMVLAPNPTIYEYLAQVSSNFYYSFIRRGICLPSSCTTEDVHTIIKKNFGQEFGWRLNTVSCTTKSLKKWWPNLLQKFAIFIISSLLIITFIAAIYDQMSSKKNKTISRVILMWFSPISNTKKLLFSNTDDENFNCIHGLKFLSISWIIVVHTLAWIDLNGFRNSFRMKIFLSTLYFQPLFKGFFAVETFFYLSGLLTSYSAMKYTRGDYKNLNKTTYMLLRYFRLTPQLILFMLLLTLFPPMFDGPIWSQLMTTISNQCSKTWWHNLIYLQNLIDIDNMCGLHTWYLAADMQLHWFSLFPIIWIIKNPRNGLLLTKFLIIIFIFITGFHIYFKNLPPGGIVTTQSDMLEEDRTPGAFTDIFFKPWSNAYVFFAGFLFGFHLYDSKLVHSFFWTKTKIVACWLLIIYSYLFCIYSTIPWVYGQPYNRIWSSILYPLNRIVWSIMLTLLIFMCITRPQSMIARILSWKAFRPFSRMTFSVYLTHALVLYVALGSRHNLIDLSITSLTFLCFSTLLSSYAFGSVFTILFESPIINLFGYVKHDLLRQLQRQQYLNNKNNNDDNDQKKQMPITNNGTNTSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2P1</accession>
    <name>A0A922L2P1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2P1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="78" mass="9462" checksum="3BC217E2DD9A1440" modified="2023-02-22" version="1">MKHRMLTIIVVYTHISMRVYLVGIDKDILPINDNDHFNPFCRQHDLFFMIKAIENFNYIYLFDTNSDDFNKDLNNYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2Y1</accession>
    <name>A0A922L2Y1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="13">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DERF_006761</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54232"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:76979"/>
            <dbReference type="ChEBI" id="CHEBI:78228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:54233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:74963"/>
            <dbReference type="ChEBI" id="CHEBI:82949"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:54333"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:75466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:54245"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:32940"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="13"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2Y1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000002">
        <property type="entry name" value="Choline/ethanolamine phosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="391"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9515996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="422" mass="47277" checksum="974D47046BCAE0DE" modified="2023-02-22" version="1">MAGRFNSLLNAASSVVCEKLNDAKLKRLADHKYSASGSTMLDFIMQKFWRWCIDNWIPEWWAPNAMTLVGLIVNVFTCSLMVYYSPDAKQDIPSYVLILAAIGLFIYQTLDACDGKQARRTKTSSSLGELFDHGCDAISTIFVSLSVCLSVQLGQYPNWMVVLCGGATSLFYIAHWQAYVSGTLKFGFFDVTEAQFTIIIIHLTSAIFGLSFWSNKIFGIELKIMAMIGVIGNECYLLFRDLKSILSGGAGKNGSTIAGTSILSPIIPLMLVYSFTLIIYSKSMSNAFVNYVAIYIITFGFVCAKITCKLVVAHMSKSEMSKMDTIFIGPLILFFNQYFNFYFDELTMLWIAFAYILLDFICFSYSTCRQLANHLRIYILTIRSVPNEMSSNNISSSSASTTTTTNGRHYGTRQRTGNHSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3M4</accession>
    <name>A0A922L3M4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3M4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="78" mass="8710" checksum="990352A2B70AD78A" modified="2023-02-22" version="1">MKSTMNVRPTQQNDLKDDQPAIIFLCKCDNTSLAYFKRVKSSELIPCSSSNENLYARKSPVSFTKVTAAICGHNINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4J4</accession>
    <name>A0A922L4J4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras protein-specific guanine nucleotide-releasing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RASGRF1_1</name>
        <name evidence="5" type="ORF">DERF_011185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1294"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="507"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="697"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="939"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1534"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <begin position="285"/>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
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        <location>
            <begin position="697"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <end position="862"/>
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    </feature>
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        <location>
            <begin position="944"/>
            <end position="953"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="959"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="983"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1028"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1052"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1075"/>
            <end position="1104"/>
        </location>
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        <location>
            <begin position="1541"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1551"/>
            <end position="1567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9506454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1567" mass="170852" checksum="B919CC55F02116D5" modified="2023-02-22" version="1">MRRFKTHSASSTGHHPSSSSSSPSPSTTSSRKSSSVSGLFKSASSPTPPTNFSTNSNNNNNSTDNTSSNTNTGGGGGTSYHQRSAALIRSYGRAINRSFQSGIGYMSGHGGNNNSNHQHHHSSESNNSLDIPETDHTMDHHQIYWICGGGSGGLKSPLSPKLQSRFKFSKNKTKSKEDQQQQQQQQQGRNFQETSSCPVLIAATNDDKNETKTSQNDTNTVPLLKQQNDESENLKMEISRQKITTVKTRYTTTKPSSMVTTTKNQSTKPILMKKIDSDEQRNQEYSHQPKPKQSSSDSLMLIGNQKSVVIDKQQHSTIKQQQQQQQQQKQQSSSLSSQLKKDSKTTAILTSNTSSSSSSRSLNKKQSIGKLRKMIAMEIVAIPNQIVYEEGDNNKCIDNVHFNDLFHGTLNDSSSITMPHSIRNDPRLFKDDVDIRFSRTLNSCKLPQIRYASPERLFERLTDLRFLSIDFLNTFLLTYRVFTDSITVIEALKRVHYSPDLSTMNASLHDSSGSLEEGTGGGGGGGGGGGNNNANGNTTTKIDSTHLHPGQSPYHYSGIITTTNSLNTSHSNTGGGVGVGGGGGGGGSSGVSATIIGNVNVNNVSAANEYLSTTIDYDYSRRVSNSSVLSDLNDLGHRESIVSTNSESTAGQQLAQVQQMFASNTIRNNQHWRLSYLEEEQARERYLKRMNNRLAHGSISSTTSSNVGNNNENIQTTSGSSNNTNTGNNISSSSGHFQLPAGEPMLTPAITDPIAVPVPPPPSPEVPGYLQKSTKEASSTSSLMADNKESATSSSNDDRSPSPTESSSSHQSKQMTAIHRPNQHLRIITNNNNNNNAAHQDQVLSPHSQSCDTLTNNSEQSYPASPLSSATSSATLVGTDSHTCSPKPSPVQKTSPHSLPGQNSAEHGAVNQDYETIPEENVENRQRLVQNTVAALHDQLSEGTPPPTPPIPGTPQKQSQHHQQQHHHHHYHHVHQPPPIPSHPASSAPPISSVGSCFVLPPKSQNPKSTESRSGSISVPPPVKSSESRSGSIGHSSAPSGRLSATSMNYLRVRGAGSKRGSGSSECESMASSSVTPRSSFQTDTSISTARSSFQHPESPQMSSKAGVVVISSRATSRRSSTASAASAFAAATAASSNPPEPTDPMMKQVIVSRGSSRFSSAAGADLKIPNSQGTGATQNAQNIAANNERIAQRAKRESMISTAATMRVLNVLRHWVSKHSQDFENDQKLLQITTEFLEELVHNTNLLPAEHKAAVQLQQMIAKQTMEAKEKVDLDVLLAAPIQPSQDNIETLSALEIAEVMTYLDHNIFIRIRSEEFLGQAWMKEDKSKKAFHILLMTKHFNDISRLVASEILRVPELHKRVAIIEKWAAVADICRCFHNFNGVLQICAAFTNSSVYRLKRTWEKVAKTTKQTIEKLQTLVSTDGRFRNMREALHRCDPPCIPYLGMYLTDLSFIEEGTPNFTDDGLLNFSKMRMIAHVIREIRHFQQTPYKMEHNPKVTNYLLDTSRHLQDDELYQMSLTLEPRLSRFSPRIHVPNVGSTATSPSATTGNQTVASNNNDNTTISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5F4</accession>
    <name>A0A922L5F4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LYR motif-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LYRM5_1</name>
        <name evidence="4" type="ORF">DERF_008387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5F4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20265">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045296">
        <property type="entry name" value="Complex1_LYR_ETFRF1_LYRM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="3">
        <location>
            <begin position="54"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9517750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="178" mass="21019" checksum="07EEA1BC5195F95F" modified="2023-02-22" version="1">MLLMINSYSTLNINNNKVKISMYPPSISCTLKLTTMVNGGSLGGPNVQRQLRLQVLNLYKTLLYYGRDYPLGYKYFRDRCHKSFVKNRDETDPQQIQKHISRGEFIIKELEALYRLRKYRYLKQRYYPEKLDDDDNDLANKIDPKLILKKFEAKTTTTTTNQQQTSVVMDSMKEEIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5F5</accession>
    <name>A0A922L5F5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RPS3</name>
        <name evidence="9" type="ORF">DERF_006851</name>
        <name evidence="8" type="ORF">HUG17_1404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5F5"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="7">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7645866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9516089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="237" mass="26566" checksum="D1490B0231E9E868" modified="2023-02-22" version="1">MAKEISKKRTFVNQGVFRAELDEFLRRELAEDGYSGLDVYTLASKTRIVIFATRTQSVLGEKGRRIRELTSLVQKRFNFDEDKVEIFALKIADRGLCAIAQCESLRYKLIGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGWMIHSGQPKNDYVDVAVRHVLLRQGVLGIKVKIMLEQDYAGKKGPKIPLPDNVQIVNPKEETLPAYPFSESKLAVEPTKIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5S2</accession>
    <name>A0A922L5S2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Equilibrative nucleoside transporter 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_007200</name>
        <name evidence="8" type="ORF">HUG17_1653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5S2"/>
    <dbReference type="OrthoDB" id="46396at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7646115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9516464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="443" mass="50917" checksum="CCE6F2D357F045B6" modified="2023-02-22" version="1">MTSRDVEPILDINGDVRESEPTLDTYESSTNINEDIDSIEIDRFHLARILFFMIGLVQLLPMNFLITADDLWNYKFRDVNSTDTHDKTELQKFFDSYLIIACNSPFLLVYLVSMTQYFHRITIDLKIHLAFIFTIITFVVITIFVKIDTDGYQNAFLKILLILVFIVNAAAIFIQAIFIGLAALFPLKYVQTMVAGQAMSGLFAASTKIFSLLGHRTLVNNVFIFFLLANLVLIATFALYLYIRKKPFYSSFVYASSSLENNVPMNLSLFGQIFKNMWPFCLTLTFVFWVTISIYPSLFVLITPVDHETVIPEKFILPITCFLVFNLGDFLGRYMGQFVLLTKNHGYTIMIISLFRLLFIPIFLYCNAQPRHHLVFFTSETFFIIFNFIFALLNGYLVLNVFVNGPQLMPEEYRHMSGYFLIAFLGLGLTLGSLTSPFVIDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L615</accession>
    <name>A0A922L615_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger SWIM domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ZSWIM6</name>
        <name evidence="7" type="ORF">DERF_004903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048370">
        <property type="entry name" value="ZSWIM4-8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619:SF0">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21055">
        <property type="entry name" value="ZSWIM4-8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="508"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9521229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1570" mass="178213" checksum="8B8DFE61C751ACB3" modified="2023-02-22" version="1">MSSSSSSSNDDPSSSSSSSKRLCMEDDNNNNVIVAVDQSDANNDNKSICSNGGRNYSVKTYVTNNNDDDDDDEKNFESKRKIGSSSSSSTINRNDDQPPTTSISSSTTYSNRDCSKQSNQFRKLRTSPSSSISNYRIHSKVAHGRCLYFPGAYSSHGQLSNQSHQYQTRRQCAQIYCCRCQHQFQAPIPPPSPSQSHPTSSLSSSIQQPNKEWTIRLRNQNSNGHHSIIGRSSRIQSDKSTIPTSSTTTSTASTSTGTDLINPNSLVGQKSTYEPESLLEISARFVAEYIPYEYIEQQYSCIPEPVQKRIIFWSFPRDERYIRLYSSISSIFKQDFNLANYTNGTNSATAAAAAAAVGTSSSSSSSNLIGNQTTTTTTATTSTASHHDHEWESRSTFNKGLHLLCSGTVRQVMQIGFNLTGIVIDLQFNKQSHPSIQSSGSFYPTISSYPSSSSSSSSSSTALAIQSSEANLMKLFQGDRNGTYHSSYNNHNISDSSSSYRKTNLNGCLVSITFDRCKITSATCTCTPRVVHLFWCEHVVALALYRIHKPYSFDLRIPISETLLDMDRQQLQKLVQYLIAEHHVQILPTVQRLTDELSQKHAPINLIHGAPDPTAGACVYGPHDWYLNEERTAAQIRDLVKYVSISESNKIILLFYKVIEMLKIKDSNGSRFLRIITEQFLYSYSHYLKPEDAFEQMYFDPFIFLWDHLTNLWTFIVADPSLSPLKRVEWREMFRHWSHISNCPREDTYFNLNVQTTHDTSHRCSSSSENEPMAHCSKHDRRLIVNASRNGHNVPFRKRRILERALDASYITWDDAHLQLILRQDGPVDGKSCLYYYSDDFDKDGFPIWSEHLPTACVRVASLRVNGRLQEALRLSMAIVRLFRHRQHIQEQENIGLIHVVPSSDSWIGNPLDPIEILFDTLAEASVTSDSRSYDAHYALIGYDKKIDMGIFSRNVLVDMFVMYNEVNGLVDKDGNMASNVNDNNDINNEKLKFNHVKVPGSSQYWDTYLNAAVYIALVGLSQLRRSPDLESQRDRSYRQEERLIRKLLDIKLDSILISTIQKQARYLIEYGILSDMVTGEHRQLFVPSDVVQIPGLVRYMFGALLPTFPDLSYDIGLRSLRFFAFKDEHQSSTEADQLPVRSNFFDMYLDVQSLLARTMLFAARNDYAQLLLIFETIKTYVIDPHYLNKLAQDIFNFSSNGNRQEYLLRIAYQFGLHLAKITLNDQTNDSCRKNTIHWLVTCATEIGYDKIVYLMRNWKEYFSPSEAVRHVASAVLAQNFNSRLCVRDHIMRSEELASTARKLAVECAMRDPSSCALNALSLCEKDQYAFDTIAKVVETAASLNQIGSHKLFTIARYLEHQGASERACKIALLAANQVVIPLTADSHHSINDLQWACSLAQCLGTEELNKLVDILIKNVRCAPVLADMIRRCTLPHPVLPKPVMIGQNNVRTNNINLSYVPDSSNIVMEHLSLEERMRRRQFKTYPLDRPPLCNLLYAAVKAYIEAVMRRLEHISPRHYGDFIEFLTRAQETIILAPDGKNEFAKLLENIKTLYKGKKKLMCLVRERFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6N4</accession>
    <name>A0A922L6N4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6N4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="100" mass="11525" checksum="17E35168F0C15D7D" modified="2023-02-22" version="1">MNKILHPSSSSSSSLIFENLNDSNSNDNSNSKKKKIESSSTSSFVEEFFFMKQKQKSLKNFRSDWKRGRDFIQASLDYDYYTLIGCSNALSMFELVLKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L776</accession>
    <name>A0A922L776_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L776"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="121" mass="13584" checksum="3853D18C40BE6FFE" modified="2023-02-22" version="1">MPNRVIFLDFLDQTILVTTTNIATTSIIDPSGHHCHHQHHHHCHRYNRTRQSIYLANIFSRSIITCLTSNIMFMMMLMMMFNNQSQSTAIAHSSTAAAAAVAAEVIVGRGDDGMEGNRNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7I7</accession>
    <name>A0A922L7I7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phospholipase A2</fullName>
            <ecNumber evidence="2">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_000269</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7I7"/>
    <dbReference type="OrthoDB" id="10021675at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000304">
        <property type="term" value="P:positive regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047148">
        <property type="entry name" value="PLPL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139:SF34">
        <property type="entry name" value="85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="7" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="10" id="KW-1053">Target membrane</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="340"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="14">
        <location>
            <begin position="507"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="13">
        <location>
            <begin position="511"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="13">
        <location>
            <begin position="543"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="13">
        <location>
            <begin position="679"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9526166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="845" mass="98497" checksum="FB280FF9F84A05CC" modified="2023-02-22" version="1">MSDSNSMNNKQQPRYFRRTTTITTKSYTINYGIIEVIDWENHEKLLQKDRILLKNNRNVWHYEHRSTINRYEIVYRQNNPLQYSFLVFHSLCKNDSDQYFEHLSAVLNNLSEYMTSIKFEAFENLKTIMEILSTNPNWSTTHVAARLGYSQFFKNKRDIAIKEINLQIQPDGMTPLHLAIHHNHKAIIEIVLLDLYPNLNLLDFKQYSVLHHAALSRRDIFRLILSQPNMFDRILWKNHQGSTALHLACFARNYLIVYEFLKFGLTIQMLTLSPPKNRLKSQKIDNGNQQIIRFTDQDLGDLDRQDIEMVGSPLHWVKHRRLMEKLINIYKFPLNIRNLNGETPLHVMVRRKRIRCVITLLCSGAKIDAKNKFGNTALHRAIKADEITLSQALIVFDANIDAINNRKESIRHLAALASTRDQSFFSQHILYLVSSLGARRCPKDMVNCNSGCSYDGDFEGRWNFVIMDLTNQYEAIFSNLKNSEMFDKEMEKSDEEIANDKNGVNMLCLDGGGIRGLIIVQVMLEFQKHMERPFIDYFKWIIGTSTGSLVATYMVIGKTLAEIRNIYFQFKDKVFVGTRPYDPEPLECLIKEYLGPNLMMKDLKGKYGKNVIIPATLHDRVPMKLHLFRSYPSHLELLKKPDYDRGFARHPCQDQIVWKACRASGAAPTYFNSFGPFIDGGIMSNNPAIDALTEFEFYNNALKQVGRSDECEKLRFVLSLGTGRQQTESCKPIDISRISLSLMEVNNQIRYIYQMTNLLLYELCNTDNHIVNRAEGFCSAANILFFRINPQFNKLIELDETLDFKIVNLLWETKRFMYLKRNEVEQIVKYLKKFTQFPEQQNVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L817</accession>
    <name>A0A922L817_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_000206</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L817"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="472"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="526"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="599"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9526089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="720" mass="84213" checksum="739782B5823FA9B5" modified="2023-02-22" version="1">MAPVTRSSLKNIVNNNVIDKCKVKKNKTPVNKSKKKLIKSIVVEDFDDEIDNDKDCDFDPEESSSEEDDEKMVNNDSDFDVESDKKSLKTKSQSVKRRIKSDSKNTPAKMKKIASTKKLDDNDEDSINVNVSIGDNDDTDGDDNDDDDWEEVEDIGVYKNGDDFNLENYNPDIPDKIQISFGNPNGLRQKKNKSKQWDWVRQCIRVDMNHERKRNQIYAHQTHLLLSIYRIQYLNSIIQDDLVQALILSSKLFQQLKIKNKTNNMEKMIEWFHEIFNVSIKKGKKSTENIRKELMKAFESNKITCPLILHLIMISFLRHVGLKVRLCYLLCPVPVKAMNLLTAKSKFEKNKSEPILGGDIPKIAESQCYWLEILENDKWKSFDLFNEIYNDSLAITTKRKRLITFVSYVFAIDNGGFIADVTQRYCSLWYSRNRVKSRVDDQWLQITMQRFQRIENSPEMKADQNEFDKMLENAELPRYRTNYKDHPLYALERDLLQYQAFYPPNPSTLGFINNEPIYSRDCVHLLKSRERWLRDARTVKLNETSYKIIKSRLKRKRKSSSMMMDFDGGGSEYGREELELFGYWQTEPYIPPVATNGIVPRNAYGNVDLYQKCMLPKGTVLLESKPYLMRLANQMNIDCASAIIGFAFKKQPNRVNFGPVCGGYVVCEQDKDKLLNAYEKYRIEQETKDRLAKEKRIYGNWRRLIRSVIIRQNLKIKYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L874</accession>
    <name>A0A922L874_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L874"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="542" mass="65045" checksum="81FB299114F6881C" modified="2023-02-22" version="1">MNVKLFRRSDQKAELNISSAMQRKISWTYSTIKPAIWITLNGWISIVFLVCLIIWPHNDYVMSIDTFDKIFGSKRNDFLVIHMIIVFILHEYFWYHFLLEVIHYKSAMNDFFINNWQYDDQQLSPQHRNYLIQFFRKSQFMAVIFLRCFIIGLLAIQFIFSNFSFDLFESYQINLTKLVLSSTLFFSYNIQCIYFIGNVFKSISFTVFIMEFFIVRLKQLSSKSALILQNSFQSSIKVQKLFWYRFHYEYVTLYSEMAIFNLTARNILFFIELLSKSSVVICLLFISQQTKMNIQITFVALAFILYFRVAHMPSYNRICWLSIHRWIARTQWLSMQRNVFTNSFPLRYSLKSRLFVQTMTNNLFGFTCGRMFFISKFKYIQIFLFINDYHNNVSTIRILPNRLECLYVVTATWSFHVCGICESNFHILMTYPSIENAEIKFCIRRGFEIIKFYNLRINYDLFDYQQRKISWTYSTIKPAIWITLNGWISIVFLVCLIIWPHNDYVMSIDIFDEIVGSQRNDFIGRPRKSRGLVQSRLEKREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8E9</accession>
    <name>A0A922L8E9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8E9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="117" mass="13497" checksum="EDA55D28123B3E82" modified="2023-02-22" version="1">MPQIVQSTIKTRNLSISGIFVDLLQLVAMNEWLFHYLIGTFKHEKRKQAKFWIHPKRPCNHESDMRPLSSSKLRGDPEMHGADSRSNTIHTTSEYGSEPQTPRLKRKTEASRSSPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8X8</accession>
    <name>A0A922L8X8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC protein, sub ABCG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">wht-4_3</name>
        <name evidence="12" type="ORF">DERF_001732</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="567"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="784"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1201"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1273"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1315"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1367"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1402"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1491"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1969"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2058"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2099"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2140"/>
            <end position="2159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2166"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2250"/>
            <end position="2271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2680"/>
            <end position="2697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2742"/>
            <end position="2761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2782"/>
            <end position="2802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2814"/>
            <end position="2829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2836"/>
            <end position="2861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2923"/>
            <end position="2948"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="130"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1637"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="2354"/>
            <end position="2596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1551"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1561"/>
            <end position="1594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9527726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2985" mass="347234" checksum="6415A8CC8A800D74" modified="2023-02-22" version="1">MIDSNNNVNNNNDTDDESSSNVLKMTKFNNIKINNNNNHLDRQSISVDVMANNHDEMSSSMKKISLAWHNLRYDFDDDFQSIHRQQQDYNHNYRKKINKFSVKNLLLFHQRRGSIPSTPTITTTTATTTSNHPTVTNKTRQSSPILRRLTGYFECNTVNGLLGPSDHARKTLLKCLTNSMRYSSGLSKDSRIYSRIANDRKKSSNYIAWIQRNLDDLITFNQMSVRELLLYSFVFRNGILSLFKSGQYIDKILEELSLKKDEIIDKKFHELSFGDKRLIVIAQEMMSIKSMPSFMFLDEPFEFLDIIQAEKLLFSMRNISRKHSITMIISAQTSDAYLISLLDKLYILAHGGVCIYSGSPGSLILTMEKDLGIFNQSSQDNDNDDDEEKNDEFVAIEEMLKISCLEFTNPKVRKLADKTLLEEHQFLSSHLQELKFQPNGIEIPGKCFTIVDLFIQSFRHFSLLYLTRWFPLKLLTPILYYLFLAFFLIDSKMIIANRCYDSISQRLIVPSNQTCQQIVHEQMMIDGYVTYQMYSMWFVASWSILITSLYCSKMLNLFRNDHQNRRYSFIVFVFSSFFINLIESLFWSTIFTCLMYFLVDHTIIENYYHHHHHHHTATTNESIMNKWSNVNIYRFGHILLSYWLLYLYHQAYGILLSCALYPKLSTTKSANNYSIVIITSIGQLIVIIFQLLNNNILVIIDRIHSSILRSIAMTIISLQPIYNSVLYAIYGLERSCDHYFKIHHHHHHHHQSHQNDYHHSSRYSSSVFKQYSIPLELDVIFKHLISIVIIVIVIRSISFLLVWYYFCPKFRILCLSSTNNNSTKSSSSNQNQLQLIPIDYGPLNRKKAKVRIIQPIFKDDDEHGVHYHYLLVVKNLPIKNFRLGSLNAVIGGGCEGGNGGDGCCQTSIMGCQNGSIRTLLLRIFSGQLKTRLTLDSRFYESQFATNNVCFISRYPREHLIPGLTAKQLLIFSSTIKNIDDDDYSNGRLDHEEMALNILDELDLGHRSGTFVDDCNQSECKRLALALELTSLQMPNLICIDEPTFGLDAINSEQFVRCLRQLTDRHSITFVVSFQHAQHQILSQFDQIYCLSSSGRCIYSGPATPRSIRQHFNQSFHMNHETSSSSVSCKRAIEELLRYSCLDCTIPAIEQLVKQNDQQTLKADELLPQETTSLEYKGIKSNIASFSIMSIMRLSHRYRGRWLYSLWFYWIIFATICSMTALLLNGLFGSEITQPDGCIRKDIFNATAICPQYRTGTKMIWDEDGEQLWDNYRYVYISTHLFLMIILFQSAMIFYREIKVFLHEHQNGWFSSSVFYFSHLIWIDFLPIIPITMIYLYLIDIDHLDHYSYEPDDIIDTDHTTTSQQQTYYWWAVILISIATESIHSLGHLVVIISINRIRSETIFLIILTLVFLLSITSNFQIHTRFTLSFLNVFRYLNEAILVLHYGYFHSCTIPLSRSSYIRQQQQPISLVLYRIDSDLNPDIHFYHCFRVLIYQTILFRFGSWFALLLRANGDRIFHHHRLWITGKSSSSTNQSYLDHYEWSTTTAKAATRHSYHHDQQTEQQQQQQEPSPSTSTESTVSDLSAKLSSSPSSLDGQINNHSDDDEKLEFLSIMTQQRQHPQQQTNELNISLVWHNLRYEASHWLHHREKVPILRCLTGSLEYHNLTGFMGPSGCGKTTFIRCLTGNMVVRSGLSSETEIYLNPVEKRKPIIGLIDRAVHEMIYGQLKVGEALRYAFLFKNRCISKHQMNEHIERIIEELMLDKKILKRRFDLCSGGEQKRIAIAQELMSLRRQPSFLFVDEPTTGLDSNSALVVMKCLRRLADNHRMSVTISIHTPNSDILHLFDKLYVLAKGGVCIYAGPPDQLRPLLKEQFGLDSSCDDHQEDELEKPPIEEYLKIACMGIESQKVQTLAHNVQKLEHDRLMPYFDQLDFLPYGVPQHFKRFLFKDFIIEFIRLFHIMFMINYKSVLAVLLTFTYLFVFISTVFNGEEIVRSKACCELPDQSNFSLSKISNFIIEDNNGDNSNGRNLTDLENCHDNLRNSAHHDSFIMHQSMTTLFISSVAMGLACFLFVPILKVFRNEHRNRWYSVGTCFWSLTLIQLIESILYVLTSTSLIYFTMDFLYLDQNQFNWTRFGHFLFFYWIEFLYMQSFGHFLLILAGDRIQIFMVLVQIFITVLFVFDGHFIILEQLGNPWAIKISNFLASRFINNGVLYAFYGLDRCDDPLTEYSVMLHKYSVDVEKIFENLKPVFRNMFILRLLTLICMWIRFSFKGKINRMYRQSANDGISSIVDYDQDRQTSKSSSNNRKRSKNCFKVRFTTRIKPDVETKFENFCRGKIHLAWRSLSLFGERMIRESPSIVKMTNPKLILHNLNGQFRFGTLNAVMGTSGSGKTSLLKVLNGRWKTYLSAESQIYISKYTPTRICYISQEISGHLLPGLTAKQSLIYAAKLKNIAERFYGQTFRGGKIDYEEIATNLLDELDISHTASTFVDYCSDGERKRLALALELTSLRMPNLICIDEPTSGLDSNSAAIEIRCLQKLVRRHLITLVVSIHQPNTEILQMFDQIYCLARGGVCIYSGVAEKIAENLRLVPEINLPDPCGCTVVTEELMKYSCLSNEDRIVQMLCQLSDQRILTQEITDEEFEDDVVACDDGIQLNRPRFSLTSFWFLFFRNLMYQKNYLWLETVSYIVLYIYHGYLLRFVFNPKSVHTSGCVSFDEDFNHLSTARLQEQIDLVNNTCYTILMNSFFLLIFLVQSGFALTKEFVYFFNEHRNGWYSTMSFYLVKSGYEILALIPIILVYNYIVDVFEPVRPGMYWWMVILTFLGALVIQGQSHLFALLIGSNFIVLIVVTFSNFFTWFVLSNTFNPIEEMHYGYQFVAQFSVLRFINEALFQLQYGFDRCNTGEISIVLYKMMLSRDEQGQYFYHCLRMLLFQIVFYRSIALGVLIFKCNPQQNRRTRGHRIRESFRQRQSLRSNQLDTFMPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L923</accession>
    <name>A0A922L923_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit rpb7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">POLR2G</name>
        <name evidence="10" type="ORF">DERF_001853</name>
        <name evidence="9" type="ORF">HUG17_6850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L923"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="80"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7636644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9527861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="171" mass="19153" checksum="5A7A8D08C2C62837" modified="2023-02-22" version="1">MFYHIQLEHEIQLHPRYFGPNLLDTVKKKLFKDVEGTCTGKYGFVIAVTTIDSIGDGVIQSGTGFVTYPIKYRAIVFRPFKGEVLDAIVTQINKVGIFTEIGPLACFISRHSIPADMEFDANANPPCYKTKDDEMVINQDDEIRVKIVGIRVDATDIFAIGTLMDDYLGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAA7</accession>
    <name>A0A922LAA7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitric oxide associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NOA1</name>
        <name evidence="2" type="ORF">DERF_002250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAA7"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01855">
        <property type="entry name" value="YqeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052807">
        <property type="entry name" value="Mito_transl_resp_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46406">
        <property type="entry name" value="NITRIC OXIDE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46406:SF1">
        <property type="entry name" value="NITRIC OXIDE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="445"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="836" mass="97341" checksum="EAF7412EF5B3AF46" modified="2023-02-22" version="1">MTLLTGTNRLLFFIQCRQSRHSVSEYRKRKSLLSNYRIDRKSDEIGNVYEKLQSPLNELVPVTPNKTSITIDVLDRETYAQLSEWRKANLVRRARRVLPLPISLTTDDKLGYRWKQQFIKSLKKRNILASRNLYDNPYESIPDFVRLMNDTNEEMLREKFPEIYEKFKSIRQSASDYNFKELVNVDKTAYFPFSQTLKSNELLDSNEKLHQEVGFNDEEYENFLKHNELLQFLASNIKAGPLSEYEPEIRSWASQIWLRNYGKSDPSIAPSKVPCSGCGAHLHCTSQNIPGFIPAQKFTLFNEKELESQRCQRCEFLTKYNVSLNVTVSDEEYPNLITKINSNKSLVIILVDLLDFPCSVWPGIVNLIGEKHLIYIVGNKVDLLPKDDRFYLERIKESLKESLKSTHISRESKIRDVSLISAKNGFGVDNLVTKLLRDLKPGQDIYLIGCTNAGKSTLFNVLMQSDLCALTDDQDLMQRATTSIWPGTTLNLLKFPIRKMKGWEMQIRLNRLNVLEKHYIAENILTKNLRRQSQIRYAHLSERINTDISTTTPFLMENNHPLIRTVRNRGKKPFEPMKKDSMKLNYLNDTPGVIYKDQLLNLLTTEELLRTIPREVITPRTYTLRPEQTLFIGGLARIDLTHARQHVWLTVFASSYLPINIVYTEQAKRFYETYIGTEFLAVPLGDYERLKYWPQLSPKEIELELLGWEKSAADIVLSSAGWISITGNADSKCILKTFTPEGRGIYTRQPPILPYAIRLRGRRIPGTPCFENKLFTIDDDDHHHHGYYKNHRHTDEKLNENSETMTMDDHIRRRRRKHTKIIDDERLKKARTFIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAC1</accession>
    <name>A0A922LAC1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ras- protein Rab-2A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Ras-related protein rab-2a-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RAB2A</name>
        <name evidence="15" type="ORF">DERF_002292</name>
        <name evidence="14" type="ORF">HUG17_10256</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAC1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01866">
        <property type="entry name" value="Rab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000275">
        <property type="entry name" value="Putative ras-related protein Rab-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7636286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9528339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="212" mass="23676" checksum="F8AF9CA5BD5B583A" modified="2023-02-22" version="1">MSYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIENKQIKLQIWDTAGQEAFRSITRSYYRGAAGALLVYDITRRETFNHLTTWLEDARQHSNSSMVTMLIGNKCDLESRREVRREEGEAFAREHGLIFMETSAKTAANVEEAFISTAKEIYNRIQEGVFDINNEANGIKIGPQLSPSNQKSSSGNQALGTGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAN7</accession>
    <name>A0A922LAN7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vta1/callose synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_002487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAN7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9528548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="358" mass="40443" checksum="0F096F39C1FF790D" modified="2023-02-22" version="1">MDQQTLDAFLKQSTTKPIYKQYLPFMKLARDCFVQNPIITYWTLCYVVEAALKNQTKPSDDFRKFLLEIMSCLEMEKKSRSSTGDRLFLDEKEAQKFIEEYGNKLVEKAEENEELMEKYDLAYKLYLSASNIFQMYTVFVRDDEENLKRIKFCKWRAVECFKKKKEQDENPTPKPEDNDIGGGGGGGGSDGSLGDNNEQHHESSCPYPSGGTSTSSTSNTLPYPSNIGFSPGSNDYNNVHFNEPINPIEPSPSSSSSSIQYPTPAPRATPTNAGSKPQDDRQKQLAQELASLQLSESDSKRAELLCESALYAIRANDLLTAVETLKQTLELLYKLQRARIYSNNSGHQHHHLSNPNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB23</accession>
    <name>A0A922LB23_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane emp24 domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TMED10</name>
        <name evidence="11" type="ORF">DERF_005272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB23"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="37"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9521635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="214" mass="24605" checksum="B2C4E80B6D75AB1D" modified="2023-02-22" version="1">MIKMNKNLVIISVLFTIMAINCPFGHSIRFLLQPNTKRCLKEEMRKDVLVTGNYSLSDSPGVRTDLIITDTKGHAAFNRENIDKGIFAVNSDEDDIFDFCFISYLQAAHQMPQAREVHIEMKHGIEAKNYDQVAAISKLKPLELELQKLDDLSAAIIGDFDYMKKREQAMRDTNESTNARIFYLSIFSMLCLLGLAIWQIIYLRQFFKAKKLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBJ8</accession>
    <name>A0A922LBJ8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBJ8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026069">
        <property type="entry name" value="Fuzzy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13559">
        <property type="entry name" value="INTRACELLULAR TRAFFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13559:SF1">
        <property type="entry name" value="PROTEIN FUZZY HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="401" mass="46415" checksum="B13AC0A6E0927BA6" modified="2023-02-22" version="1">MFSLQLMAFSIDIGLPLFIRRSDFNNETINSDFQLNSSTVFYGLNQFSRLNDCLLKYAESKGNRIKIKWHSKGKVLLIILCQEEYLLREKHLDRFLVLIINAIQMTCGPDVFFIEDFDKQKRDLKFAHHLLDCLVNLFVSTNVDRINVIAHSVNYEPIDRSKSINSFLSFLNRLESIQYWALFVQEKLTFASKEWWSTLVSDHHTYSCLICYLINSFTDTVLEKGMEKITIFLPYENNVIPQNLTIIPLAKHLRVCLISSKNSNLNYLTSEIPAINDSTEPSSILNSSSLLNGDNDKAISAFIIFNTKHRIHSIYNPTIVQNYLDEIIVFCNCDFNSENEQDSIIANDHLIMCKISNKHFILCTLFTSINQQQLSLQKLKKLTKNLAFNLLNLNKNKSIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCB1</accession>
    <name>A0A922LCB1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hex-4</name>
        <name evidence="9" type="ORF">DERF_002986</name>
        <name evidence="8" type="ORF">HUG17_5021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCB1"/>
    <dbReference type="OrthoDB" id="10023921at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06565">
        <property type="entry name" value="GH20_GcnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040:SF8">
        <property type="entry name" value="BCDNA.GH04120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="7">
        <location>
            <begin position="199"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7641976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9529077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="643" mass="76073" checksum="E28539048C641759" modified="2023-02-22" version="1">MSQKKFANSHPHHHPHHHSCSFCLLNRIWRRKFLLLSIVLIFLIITITITNSRLNVFSSLFSPSYKFQYNQQQHQRQHLAASNKDNGDTFNNNNDDKMNLRNHQHLKADNYMSNSYNNDNDNIRRQSVVYIHPPGDEQQNKAYIPKNRFIHLDLKGAPPKVEYLQQLFPLLRQAGANGILLEYEDTFPYAGELLRHAVADNAYSLSEIEDIKRLAKENGLEIIPLVQTLGHLEFFLKLEHYRHLREMDEFPQAICPSRNDTYELLTNMIDQMLIAHPDSKWLHIGCDEVYQIGICDRCKHKERDELFLNHVKRIATYIKEKYNVTSIIWDDMLRQFSPDFVKSYDLDKIGVEIMIWTYVDDIYRFIPTQNWMFYAETFPKIWGASAFKGAFGETLTVPNIKMHLDNNIAWLKALDEQESSFKEIRGLVITGWQRYDHLATLCELLPSGLPSLVIDLLTATNGKYESKLLEKFHQLMNCPHQLDYTYNTMGARLFTQYPTFSHLINCDFPGSKVFRLMQEFENINKRVDDYLYDVTKHKAWLTDYNFRHNITSPWRIREGLQDYANVMYGLKSLVKMAITALGEIYDEYTVYEWIEEKLYPQLLRMEKFYNQTIKIQELRVWPRRPIKPAVDLQRFIDKINKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCE9</accession>
    <name>A0A922LCE9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCE9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="6889" checksum="0B42CBDA41B54DBA" modified="2023-02-22" version="1">MAYMYWNNKQLNEKKTSSTTNRLAKPNRSGGGHSGHINKNHRSVNGCSNGGHLKVHCIHTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCF7</accession>
    <name>A0A922LCF7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCF7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="114" mass="12520" checksum="980E1AE8913DD80C" modified="2023-02-22" version="1">MYSLINDFHEFYKSSISSFKPHEQLAHAFLCFVVAQTRKSSAFGFILSCSSNNSSSSIRSPSVISSAANVQIFLVSISTAEPISYSGLCAKIKSCSFLSTTNPFDFIRNVKLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCL0</accession>
    <name>A0A922LCL0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCL0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="7093" checksum="E798DF9442686445" modified="2023-02-22" version="1">MFKALENFHRSLGPHIFYIQATTTTYLKQTNPSNLFSATKILIKFIQKCGCQQPDFMSTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LD40</accession>
    <name>A0A922LD40_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NUP85</name>
        <name evidence="11" type="ORF">DERF_001824</name>
        <name evidence="10" type="ORF">HUG17_6832</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LD40"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7636626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9527830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="659" mass="76895" checksum="1B1ACBE4C66A3618" modified="2023-02-22" version="1">MSRMEKSKTLIQVSSEDWLPNSCLFANCHSRGFISESGVVFNFVQRLSKCQEPLSHSEMIKASRKYRSVIHSWYLKIVDDLTAQDGQMTANDDLIRQSNVLHQMEIAWHLCEILYINVSSTGTLLAQLLNWIKWHFTYYVKLADEMIVSSLPQMHENYWDIIMFFALRGDMENAALLLELHSESKSDPIFMVVQDLLKKFPIINSSNSFVIHEYYLRWGFWHESVEQAIENHSTNTSQKRSHQQLLLLLKLLVGDLESFKSVNHLFHSWYQLMVSYALFTDPCLKSDVDILIEKTMNTYYESSNDSGKSLFDKLILSSLNYDLIDVIKQSSLCFDDNWWFVTHFVDLIYNSARYADYQITDISLIRDSFVVNYANALFAHRRRFWQLSIEYLIHVGEQAADRQHFILASLERVSFDSESELQRLLTTCRRFEFGLLELSLCRQQARKWLRGSHPKLGSALFWAIRAKDKLLINHIVDQILRQYLESNQDNDVDADTITNIGGSIVLSERLIFLCKYHEFRQLCQRGQYELAAKILVDDMITSNAIPDFFQTKVIEDCLPLIQPQKSPISMSMPGPLQLNSKQISKLISSLEQVLYRARSHFSHDGDQLTMTMWSDHFGNHDQQQRQDKEGDESYRRRIQRIENQLRVAAACHLANHFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDJ5</accession>
    <name>A0A922LDJ5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDJ5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7447" checksum="D7B1A6723ED00752" modified="2023-02-22" version="1">MESPKYYNDNYYFPVLEFWIDLYLKPINTTRGSLAKCSINIEGTSAKSVEHLVPISLPFGRSHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HH82</accession>
    <name>A0A922HH82_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HH82"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="735" mass="84118" checksum="554AB3857CAEE1C1" modified="2023-02-22" version="1">MSSNSTTINDNDNNLVIVSGGSSSSSNGDRKNNLKTEINYQNEKQQRALFNENLIENHTEIASTTKTLETTDFNETTTTTTSQIDNNLLSSSLSINQTNSSKNDNFEYFLLENNNNFTVKNCCDENVKKSNTTKMVVNSDEQNINKFNKQNHDDQSAIINMTSTTTTTTMMMTTSVPSSSTTITKTLLLKADANNKLNISKAVQVADFHNNNYTATHDDDPIPSSSSSSMIMDQKSNILESSSLMMNQSFIDDKKVSSSTMEMNKNHKKTTMSTTTTTETNNIDLGSISDDDDDDDNHRFACEHGTIRKYSIRTQIEWKSSSLINSIDPQQQQQPEQQQQQRQYIRSTIVMKCLNRLQWNQQPMNNHLNGQKFLAIISDFHLDPSYSSIYDDNENIIDDIDNDDDDWISIKKINNNNHHRRDYRKTKRSKRSLYRYIRNLWQDFRRILTQDEDYYDDNDNGKQPKIKTTKTSRDTSFDDDMILSMENEMEATTTNRKCHYNNDKYWEDNTAAAAAAVVGGLSSTTVKNKYFLYKFGKNSASAATVSDDNEQGCIDCSSSSSSSIRGSSSINPFSKISLPFWFIQLTNGSIVEIRFLKQDTNLYIKNWKKYLLSLLQNNMTATTGTNVMETNRFGPHHQQVYYYRKSNISKNAKIVKMEKHIKNFTDINKNELDDDDDDNDSPPIAMIDSDQTILFDRHQSAIIDSAGNYSIKFNHQNELWPYMDGQLYYNLKVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HI92</accession>
    <name>A0A922HI92_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HI92"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="200" mass="22496" checksum="D96E4BD769D6FB70" modified="2023-02-22" version="1">MVKIFFVNLKITRSKSIDGKKRSQSKSASILVRKIKSQSERATDSLYTSEPPITLRNRNSTPAGASLIVRLSTTLTRFFNGRNDGGIDMYVRVPIMTAFFFTCSSPAKPGAESKTVDVIRVKKSISDLNRHGRLPSLPIPFERQQAATNAIFLVIIKILVVLLPTGTRTWKKTKSKSKNKLKRAFISHVYLQDKRPQMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HM46</accession>
    <name>A0A922HM46_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C1A papain C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_014375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037540934" description="Peptidase C1A papain C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="199"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="559"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="910"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="3">
        <location>
            <begin position="1301"/>
            <end position="1511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9493635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1513" mass="173710" checksum="8AEF2840B801ED4D" modified="2023-02-22" version="1">MNAIHQFGLLFFFIIISTISIEKIRAQQNDVEQDFVPLFLEVLNRTYIEPVTIDHELKSMLFDPEFIVHCYDDTFDGQQMNLYTMPHRQIVENYFTSSEVRPMIQKSGLMATMQQTEERIDITLTNLNQLMSIINECLKLEQPEKRSRVGITTLTHLSREEYLERLNPDILKHISEPQPPKDILTLPQSNCGDIFNPNLPISFDWAAKGMVTSVKDQGYCNSCTIFALMASIESQYLLLSEGQVAAKDVDFSEQAIIDCIEEDVCERGSQVKTVWKQLSRVGLIDESSSPYYGRKLPSCVYHAFSEHNVTLAHICARTGNMEATIMSAVYDYGPIMAVIDAGDELFQYNRGPNNWRCGDKTYNHAILITGWTNDHFIIKNSWGTGWGLNVRTQLDDKNYLLALRSVIKKLNFNQLSYDEFRNDIKQLATVDPDDLNDCYDSSFSERNQNIIHMDLNTIIEEYFNTPEQIQLLSMELSDGNQHTDQLLEQRVEILATNILQLTKVVLKCLESPKEKRSRLGITSISHLSEEEFQSLLGDQLYDSMQNSSSEIISGPNLQIPMKYSWTDHNAVTPIRNQFRCGSCAVFSAVATVESAYLIHYGRKRMISPQSIDLSEQSVLDCLQNGVCKDGSYVDESWNIIKRKGISTERERPYQARQTGHCNRNPQSLIYMKKWIQNYQNTEKYMQRLILQYGPISALIDARKLHHLKGPFHGYCGQKITHAVVIVGWIQKYWIIKNSWGKNWGLNGMSLCRSSLLLFYSCLVITIYQVRTQLNNENYHSTLRSAIENMDFNQLSDNGFRDDIKQLNAVDPDDLNDCYDSSFGERHLNITHMDLIRIIEGYFLAKEILKCLESPKEKRSRLGITSISHLSAEEFQSLLDNQLYDSMMKALRQNQNSSLKLKMHTHPNLQIPMDYNWAEHNAVTPIRHQHKCGSCAVFSAVATVESAYLIHYGRQKLSPQSIDLSEQSVLDCLPDGICHTGSAIDQSWKVIKQNGIATEKERPYLAQQTGQCNRNPESPVSIRSWFQCSPDSEEYIQQLLLQYGPISAIIDAPESMRHLKGPFLDYCGQVPNHAIVIVGWTQKYWIIKNSWGEKWGVNGFLHLPRGQNKCNIEAYAVRTQLNDENYHSTLRSVIANMDFNQLSDNGFRDDIKQLTAVDPDDLNDCYDSSFGELHLNITHMDLDTIIEEYFNTPDQIQLLSMELSDGNQKTEQIMQKRFEILAANILQLAKEILECLESPKEKRFRLGITSISHLSAEEFQSLLDNQLYDSMMKAMRLNLNSSSSSELKEKFISDSQKPNLQIPMEYNWADHNAVTPIRHQHKCGSCAVFSAVATVESAYLIHHGRQRMISPQSIDLSEQSVLDCLQYGVCQRGSFPEQSWNVMLQNGITTEQERPYLARQTGQCYRYSQSLVSVQNWYQNYQNTEESMQRLILKYGPISVFMAAEESMRHLKGPFHGYCGQTINHAVVMVGWTQRYWIIKNSWGRFFGINGFLYLPRGQNKCNIQYYAGIPFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMN8</accession>
    <name>A0A922HMN8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">TRAFAC class myosin-kinesin ATPase super</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">unc-54_3</name>
        <name evidence="13" type="ORF">DERF_014610</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMN8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031033">
        <property type="term" value="P:myosin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000036">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000008">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000019">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000021">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000025">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000009">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.370:FF:000010">
        <property type="entry name" value="Myosin heavy chain, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF27">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="6 10" id="KW-0518">Myosin</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1218"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1232"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9493882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1268" mass="147192" checksum="B18E82125909DA10" modified="2023-02-22" version="1">MIEIISYLILAPTVIPKSFVDARQITEKLVKAIHVDEQEYCLGSTKIFFRAGVLGRLEEMRDDRLSKIMTWLQAWIRWYFVKKNFKKLQDQRVALLVIQRNLRKFLTLRNWLWWKLYSKVKPLLNVARVEDELKALEEKLKKETEAREKEEKLRKDLEVQNVKLLQEKNDLYLQLEAERSSSGDVEERLMKAVSQKNDLESQLSDLQDRLSHEEDAHASLSSSKKKLENEIQNQKKEIEDLELALQKAEQDKQSKDHQIRNLNDEIAHQDELINKLNKEKKNLQEMGQKTAEDLQATEDKVNHLNKVKAKLEQTLDELEDSLEREKKARADIEKNKRKVEGDLKLAQEAVADLEKNKKELETNLQRKEKELQSLASKLEDEQALVAKLQKQIKELQSRIEELEEELESERQARAKAEKQRADLAREIEELSERLEEAGGATSSQIELNKRREAEMAKLRRDLEEANLNHEQAMSALRKKHNDSVAELSEQVDQLTKAKQRVEKEKQQVKAEFDDLKGSVDHLAKDKLFNALILLEKDRGTLQAELVDLQGIVDHATKNQANIEKQNKQLEMQLGEVTGKLDEANRNLSDFDASKKKLAAENGELQRQLEDAESQVNQLTKLKSSLQSQLEEAKRTADEESRERASVMSKLRNLEHDLDNVRESLEEETEAKADLQRQLSKANAEIQQWRAKFESEGLARLEELEEAKKKLGVKLQEADEHIEQLNSKVGSLEKTKQRLQGEIEDMSIEVERANALAATLEKKQKTFDKVIAEWKQKTDDLAAELDASQKECRNYSTELFKLRAAYEESQEQYEAVKRENKNLQDEIKDLLDQLGEGGRSVHELEKSRKRLEMEKEELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRLQEKEEEFENTRKNHQRALDSMQASLEAESRQKAEALRMKKKLESDINELEIALDHANKANAEAQKNIKKYQQNIKELQTAYEDEQRARDEAREQYAMAERRCNALQGELEESRQLLEQADRGRRQAEGELAELHDQANDLSANNASLSMAKRKLEGEMQALQADLDEMLNEAKQSEEKAKKAMVDAARLADELRAEQEHAQQQEKMRKAMEQQIKDLQVRLEEAEQAALKGGKKTIQKLEQKLRELEQEYESEQRRHGDASKNLRKAERRIKELQFQADEDRKNYERMQDLIDKLQQKIKTYKRQIEEAEEIAALNLAKYRKVQQELEDAEERADMSENALAKLRARNRSSASATRGVSPGQAVPKPRKTRVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMS1</accession>
    <name>A0A922HMS1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMS1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="7575" checksum="D383E8A599838297" modified="2023-02-22" version="1">MYQINLISRIFSDSDYFREKEIEQTNAPQKKTKGKVSRWKRDYEFRIDDDYNVKSYLKMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN56</accession>
    <name>A0A922HN56_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PSMC5</name>
        <name evidence="15" type="ORF">DERF_013742</name>
        <name evidence="14" type="ORF">HUG17_0926</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN56"/>
    <dbReference type="OrthoDB" id="1154031at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="179"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7645388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9497782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="403" mass="45463" checksum="5542F71611D2E254" modified="2023-02-22" version="1">MVIKLMDIDERPAGDGLRQYYITKIEELQLVVNEKTQNLRRLQAQRNELNAKVRMLREELQLLQEQGSYVGEVVKPMDKKKVLVKVHPEGKFVVDIDKNIDINDVTANSRVALRNDSYLLHKILPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPNEDARLDILKIHSRKMNLTRGINLRKIAEVMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDAEKNMSIKKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPF6</accession>
    <name>A0A922HPF6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPF6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12414" checksum="B7A5DD945A9530BE" modified="2023-02-22" version="1">MVELEIFNDGSGGGICCGVKDESVECFTFWFGTKVQKFAFIQDPTKSKKKNGRKFDSDILWYILVPQGEVFIAIFNIILVELELHFVAAVNLDFIVVGVACVVSARIMNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPI8</accession>
    <name>A0A922HPI8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPI8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="115" mass="14329" checksum="72A59009607E48BB" modified="2023-02-22" version="1">MFIIFRFNYWSFMSTMFIINCWLLYLFILYCQSDIYVFLATKNKYDRKYLYQSIECYVFMVSIIATSSMIMIIVEIIVLWYYRYQIGRYFPAYQFTCLFGRIIRMIFKCIFIKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPW2</accession>
    <name>A0A922HPW2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="19">3.1.-.-</ecNumber>
            <ecNumber evidence="19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">DNA2</name>
        <name evidence="24" type="ORF">DERF_012361</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="19"/>
    <dbReference type="EC" id="3.6.4.12" evidence="19"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPW2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071932">
        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 19" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="21">
        <location>
            <begin position="37"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="22">
        <location>
            <begin position="609"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="22">
        <location>
            <begin position="720"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="23">
        <location>
            <begin position="849"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="946"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="953"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAH9501520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1141" mass="132255" checksum="90EC94313B9A8F23" modified="2023-02-22" version="1">MRPKKIPTRFMVTKCDKNDNDELVLQLQSTFSINDKVNKYVCILRDYWKNLTIDAKEFVNIYDPKIENDSILIIDNLNGLIVVRPDVLIPITSLMSASFCMRKAWLSRMFEIFGEPNKALFIGTIVHELFQECIRRQQYNVGQIVKIFLDTIISNFTLELYNLNMTREDVMTELRPYVRPISEWLKLYAGNESTTTNNNECKKLFSIQRLHDVENTIWSTKYGCIGKIDLSLDVIVEDKNNMTKYSNLIPLELKTGRHTFSPSHMGQVILYSFIMTDKYVNYKSCGGYLLYLKDEAKTEHIQTNHNVFRDLILLRNRFVRYFDRLGVAIDERNKKDLIMKGPETLNAERICSKCEHNLDCSLIYRCFDQNLYDNPNDSHFSSTVTSHLKGREMEFFSNMLELLEIEKQFCMSSEKLIDFWNYRSEECEKSGIGLCKMKIKHKDDRIIVFQRNPKATMLPEELFTIDNDLKINLTLLEERRAVISEELINSTKTFEIYGNFCRQLCIVIGQIESFSDDQKEITIRLEKDATMLNPQAVYRIDFLKNINNRPMLINFSNLLRLMYDGDDADNARARELREIIIHGRVPKSNQNGYKFGSYNQLYNSPTLSQLNIQQKRCILGILKTKCSLLFGSPGSGKTQTIVSLVQILVEYGYSVLVTSYTHNAVDNILMKLVRFNDENDKKVDFVRMGQPRRINPKLLKYSDHDRTKKWLETENIIALNHFYSTIPVVAATCLAVFNHPLFQKRTFDFCIIDEASQVFLCTSLGPLFNCHNFVLVGDQKQLPPVVQSSYARQNGLDESLFSRLLNTSGKQDIGHYDDDFDNDEFDVGNKDSNHQNNKSSSYGQSIRIFPLFIQYRMNSVIMQVANKLTYGNKLKCANKQVETISLLDYLLSNDKCHILEEYQSSFISKIISPNLNDSVVFLDTTSIPLAFETYDNDNGEFNILPQQQQQQQRSQNNDTNDHSSPSNDNTKSSFVINLFEAKLILHVVQTLLLIYGNKNDATNFNTDNIGIISPFRRQVNKIRELFGQQFLEQNHLEINTVDQYQGRDKDVIIYSCVKSRNSNCSSVETNDSNQTPIIDSELLKDERRLNVAVTRAKRKLIIIGNCHTLNRYLPFRNLFNVLDEEQIVPLIDFNDFNDIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQK0</accession>
    <name>A0A922HQK0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain containing protein 64</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CCDC64</name>
        <name evidence="4" type="ORF">DERF_012674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQK0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051149">
        <property type="entry name" value="Spindly/BICDR_Dynein_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123:SF13">
        <property type="entry name" value="BICAUDAL D-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32123">
        <property type="entry name" value="BICD FAMILY-LIKE CARGO ADAPTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="16"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9501865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="466" mass="54775" checksum="9A27AA73C8DDB9F3" modified="2023-02-22" version="1">MKTKKEKDLILAAELGKALLDRNEELSRMNEQLNEEYTKNIELLEQEKYALRKKLNSIEIEYENKLHDLHSDLETANENLRTHVDISKQSELETNRMIAELSEQNRRLTTELKETTNRESMLEKEIQSLKEQFSARRINFSDHLGQLEGLRDEINLLTNRKRELENKISSLNEEKMSISITLDESQYRIMALEKQLQDKELNLQNQQKDLEDLRRTMIHYQNRIDSLMKLQISDLYQKLKQIYDDLYKRQHQSEQQQKQQEQNTSTMINGTIDIMSDSNTTSSSSSSSTNGESSPTARSVDHNHDSGIQTNIGLIDDLNMIVCDIQDLIKNFDYMSQCSFCQQFRIERMELERLHKTTQQDKEEIGKLKAEILQLSSTVTMNDVELIAARERLAAFEQDRQADNQSQDEIVKRALKMRDETISRKNLVEIELAKIRIELMHVNSQLLETIQQKIELSQQLEQWQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQV2</accession>
    <name>A0A922HQV2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQV2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9502015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="160" mass="18950" checksum="3E878CB139586C00" modified="2023-02-22" version="1">MFFKMVIITVLIPLLLFPYDYIVIVDALPVKNRREIALPNPYDTWGDYCRMKNPFHPKCRGIAVQKLIDISIEQMDPEHREQYREFLIGYVIDKYPNVVGKLLKNNDIIRRMVMNESKYIEQQNQPMITTTTTNDPVTIDISNDFYIRNSNNQDRSIIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRR5</accession>
    <name>A0A922HRR5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase PGAM5, mitochondrial</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phosphoglycerate mutase family member 5 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Serine/threonine-protein phosphatase Pgam5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_012379</name>
        <name evidence="15" type="ORF">HUG17_9286</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with Pk92B/ASK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7638181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRR5"/>
    <dbReference type="OrthoDB" id="2118094at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000009">
        <property type="entry name" value="serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051021">
        <property type="entry name" value="Mito_Ser/Thr_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7638181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9501538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="299" mass="33974" checksum="8B06187E58066436" modified="2023-02-22" version="1">MSILRGTKKLLLAAGLAGCGAAAAVLFTGLHKDTESFKAHASSASLLLPDYKFINLHNYIATKWDYNWDRREPNSLIAPIKGDFGSLPECDQDDYNRRLEKAKSTATRHLLLIRHGQYRMDADTDELRQLTSLGRDQANRIGERLKELDLPYTRIIKSTMTRATETAEIIHTHLPDIPMTACDFIREGSPIVPEPPISNWKPEPKQFFQDGARIESAFRKYFHRADPSQKQDSYDILVCHGNVIRYFVCRALQFPPEGWLRFSLYNCSMTWVAIKPSGRVIVYTVGDTGHLSRAQMTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRW7</accession>
    <name>A0A922HRW7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ESPL1</name>
        <name evidence="7" type="ORF">DERF_013794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1274"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="763"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="825"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="828"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9497839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1465" mass="172132" checksum="08815EC68E60A089" modified="2023-02-22" version="1">MEDKSTPGTCSGTSKSRRSTKCPLFESILKQAIWLKKQGITSQTYDQQILDTIIDNFHEHLDSGCFCVARSFTYIALATTYLEKFYSMFQSSVLFMTEHESRLHKIAEEIRKEKEKNFINDLDVNDGSSFIAENNDIVNVSNFNRLMEHSFNAFRMYEKGLQLARKEENIVNWKFLDRFGFLTNMNALFQIFSYYHLDIYAFKVLTFALTTIDQYYPQQQHSLSGTALIAVGENEIPNENIVLIQCNLLRLLLKFGFIKMAASYYKRFFGQMKFFEMINNEDIEWINSFERCMIFLVYCEISLRTRNGKQISIKLKQLIQSNYLQKSTIKRFLIKSMANSLATHFPSINYQFENYMNEFIEPTQMSVGMCRRWKFFAMFFPNTNTNQSSNIYNDLWWIRFAVLNIFSNTFETFLDFNLNNGMNCDPVFYYKLAVNLFTVTMNLFSLGKLRLTGAIYDINNTFYMDAKIKMILFKKIFHGHSKCNDEIFKISPTPESFDVENDLKIDLKLNDLNNIDNDNDDNEEEDPNSINVIYKRLRKFINHAHHNGDMDDLKESNFYHENIPIEKLSSSFIKDFQQSLIHLQKDSIFYLFQLYILHAIIVNMLIYNETKNALVICRERYLSLLNFFEYFNMKIVIPELNRKLKSGNNNSYKIIVKTTMDEQIMNGPIEKLFWIWNTFFIEVLIQHDKYLEAWPFLHRLIDISTYSYSSRMQRSQMFYYQALVLYKQLKRNKNNDEESKKMFKLITHHLVVDNFQKDLNSLEKLSTPSPKNRKKASTMTNASAIFEAPKKRDPLGSAEKEYKKSLMDKIQSSRHVIEGTRRINDFKFDDDDDDDGDLDPVNDNNKDDNGSINIPKIESSDSVTTTSRSHTNKEKFKIFIDQDCQDHQDYVNLNESLSKIFSMLTIVDRKNETTNTTTTTNETATTDLYFNKFFNFDNEMNDNNGNYNPDSITNEDVKLCLKKAISYIGCHPGHRLYSQLHYLFYKLYKLMAKSNQILCFHLAETAPYHCFRYRLLFNTYKKINSSKSPQYNNLELIRFKNEDFAYNAYVSILPKSWRFVQVKLIENGKNNPDLLLCRFQNGYQPYFLKIKSDQQKDIKFFMEEFAQIMKLNSISIHETDKKSFWRMRFETDFQLKNLLDITEKHVFGLARGFFMGQTNNRKYIACCTGFRRSLFDLAKEMKISCQDYNLLNIFIESIVLFTAEEAEIAAQILFTTNDDKFLKRFEELRKKYFTSWMKNDKLKQLFEDIEPVGLIIDQSLNQFPFESLPSLRQKGQPFFRIPSMKIAALLYEKYKQLQTFLSIKEWTGFVGTVPEGKNLAENFETKDIYVYMGHGSGSQYYRSIPNGFDVVNINSLSIVVGCSSGRVTKETKTSDVFGSAYRFLINGAPVYIGALWDVTDKDIDIYMNEFMSLWLPRWNREQQQSRKKNNSLCKSISLARDSCKLRYLNGCASVVYGLPLKNRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU70</accession>
    <name>A0A922HU70_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU70"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7671" checksum="DA28C3A9B200C51D" modified="2023-02-22" version="1">MENKFVEIKNIYLKRDVLPVCSRHFWSHHRHGKYWKPDIFRMNDHVTVVPDNQFPMHGAIIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUR0</accession>
    <name>A0A922HUR0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Innexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">Inx2_3</name>
        <name evidence="12" type="synonym">inx</name>
        <name evidence="13" type="ORF">DERF_009328</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Structural component of the gap junctions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Gap junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Cell membrane</location>
            <topology evidence="2 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pannexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUR0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005921">
        <property type="term" value="C:gap junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005243">
        <property type="term" value="F:gap junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000990">
        <property type="entry name" value="Innexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893">
        <property type="entry name" value="INNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11893:SF41">
        <property type="entry name" value="INNEXIN INX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00876">
        <property type="entry name" value="Innexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01262">
        <property type="entry name" value="INNEXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51013">
        <property type="entry name" value="PANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0303">Gap junction</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU010713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9510824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="364" mass="42840" checksum="F8307FBE9C3A5327" modified="2023-02-22" version="1">MFQLFGSLKQFVKPQSCVIDNHIYRLHYKATVLILVAFSLMVTARQYFGDPIDCISRDDIPPNLLDTYCWIHTTFSIENAWKKRVGEEVPYPGVDKTTPNEKRVYHAYYQWVCFVLFFQALAFCVPRYLWKAFEGGLVKNLMLGLDRPILPEEDRVRNIDLVSYYLYRNKKLHNTLFLVHTITEVLNMFNVIIQMMVMDRFLGGEFSSYGWEVLNFTEWDWSVRFDPMIKVFPRLTKCTFHRYGSSGDVQRHDAMCILPINIVNEKIYIFLWFWFYFMAIASALGLLYRAMTILYPGIRVMATHSHCRIVNPDLIRNVLHSGQVGDWFLIDLIAKNIDPINFRDLLIDLDRKLGMEIKDSKNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUU2</accession>
    <name>A0A922HUU2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUU2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="78" mass="8744" checksum="301ECD23B4E40F27" modified="2023-02-22" version="1">MICLGSLQGGSRKQPRPSTVTTLLNRFSLNHQPEMKNKTVFLIIKTNFLLTECDPPMNIFHGRQVNCPCQIGSSNVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUV4</accession>
    <name>A0A922HUV4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Stoned B-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_011153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Stoned B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUV4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000022">
        <property type="entry name" value="AP-1 complex subunit mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012320">
        <property type="entry name" value="SHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51070">
        <property type="entry name" value="SHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHD" evidence="6">
        <location>
            <begin position="739"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="MHD" evidence="7">
        <location>
            <begin position="897"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1222"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="700"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1223"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1233"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9506420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1259" mass="142812" checksum="43491185A453B423" modified="2023-02-22" version="1">MSNPFLADLEESYTPYSASGTQTPYSVGARTPKRRNSTNPFEILSPENETTTFLDNNNDDETSNTAKNFASAIADMSADFFQSINKTSTNFDEDVFADEQNKINDDKVIHDSDDHVNTTTITTVKTITNFDSNNDTTVFDPFQTINDDDLNFSSKRSSIEQRKSSSTNDEENIRKITSSKAKELFHSSMNEIELLAAANRVEVQPVSTNAEDSSPISPTDLLMAPQKIEPYSSDLSDLSDISPSNIVANDIRSAFDAFTAINDKKEEDDEQGKFEPITSSEILLRRVSKTAGRQSQDVDDDDDDDDDVIIRKTGEHHTDEHAIRSSSHFDPFTTVFVDSPITSYFEDGDNNDEIVPDSATSVTMAETTQHKSKAINHAKIIGLDNIIDRNDSLDLNYVGQPNVNAQGIINDAFNDEQDNNPESQSKKDIDERATDRKSSVDIAEVAIENLQPNSLRELVDNNMDYQAQTTDGDEPSLESKDPFDTSGFDSKAFEAFESRFEATDKSEKIVRIEDDPFASPYKTAKSNANNQDGIGGFDTFEPFVPKQPENTPYKVAKKPKKKRDSFEDSDSFDDDGDDDDEPEESFRIVIRAKNNDTNQSEANSNLALPLLPPPPKSPKRLPQSEKDIEQEEGELCEEDLILTGYRSSSAIKPKKTAKSFIDEEFERFFASSENRRGSETADTATTEEPEWPTAFGEAASKQQRTAAGTDSPASPQTPLYDEDTSQPLEDYPPPYLGEGWEMMLRHPAKKKLTANRYWKKIFVRFIPETCVLQLFNKKGDAQPFQELPLQASYSLSEISPQQYDQYGKIFTVKVQYIFYRERVGVRPGQIAKVMQGQIQSMGDFAKLGMPVEHSPQISELLKLGTLEYNDIKELLTVVEESMFRMTVHRDRALTYRTEEIQCCVQDECYVEQNKIGIVEKQLARVRIFFLAFLNGMPVIEVGINDLRRQGKEVVGRHDILPVVTEEWIRVERQEFHSCVQDQYFETEQVIRLIPPDACQFEMMRFRIRPPKNRELPLQVSAYMNITPSKMELKCDILVPGCISRKHGQIPCEDIAIRFHIPECWVYFFRVEKHFRYGAVHSTNRRSGKLKGLDRILGTAANPEPQLIEVTAGLAKYEHAYHSIVWRIPKLPKDGQGAYTQQLMLVRLPLSSFDRIPETFYDFVHVEFRMPSTTVSHTTLRSISVNCETPPDKFVRYNAKYEYKIGLNITYDENKPEPEYLRVTTLNNGSLKTSSHDEEEHSSEDEQPHAADEPDQDVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV35</accession>
    <name>A0A922HV35_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HIVEP1</name>
        <name evidence="12" type="ORF">DERF_011504</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000083">
        <property type="entry name" value="Immunodeficiency virus type I enhancer binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051969">
        <property type="entry name" value="Zinc-finger_DNA-bd_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45944:SF2">
        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
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    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1417"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1445"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="2122"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="2150"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="2195"/>
            <end position="2224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="110"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="365"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="594"/>
            <end position="638"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="654"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="701"/>
            <end position="746"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1112"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1208"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="1258"/>
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            <begin position="1521"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="1582"/>
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            <begin position="1753"/>
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            <begin position="1822"/>
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            <begin position="1960"/>
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            <begin position="120"/>
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            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
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            <begin position="304"/>
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            <begin position="372"/>
            <end position="383"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="394"/>
            <end position="413"/>
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    </feature>
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            <begin position="414"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="516"/>
            <end position="527"/>
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    </feature>
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            <begin position="610"/>
            <end position="633"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="660"/>
            <end position="669"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
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            <begin position="701"/>
            <end position="712"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="718"/>
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            <begin position="1118"/>
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            <begin position="1521"/>
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            <begin position="1549"/>
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            <begin position="1582"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="1592"/>
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            <begin position="1757"/>
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        </location>
    </feature>
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            <begin position="1916"/>
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            <begin position="1982"/>
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            <begin position="2284"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2341"/>
            <end position="2351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9506789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2433" mass="271632" checksum="B1F763952980562B" modified="2023-02-22" version="1">MLPTTTPTTTPPPQPRSIDIKRNEHRTTVPIRKQSVFVAPAGISSAIQQQQQQQIHHRPTDQDISEHINKLIQENKAIVGESSQLSSLSHVGGFFQSSSPIMMATSSYDASNHLHHQRRSITNSSSPSSTSRNPNHHHQQQPYYPLRRHSSSSSSSLSLTTTTTRTTGDPHQKSLQYSRLQSALLGDKCLLLENENQSTKLNDHHHHQQQQQQFSFHPSSLYMTQFPTTATTTIAQPWIMSATPTVIGYDPPSFNHHHDVMKKYSDNLLSTWSQQYAAALAASPVPVLPTNHTTTVTQSPTMNSSSSSSHSLFPSLFEPSQHHSPSLMKLTGRSDMCNQKSVIINATSSRTGTIHQNYLFDTQTSAGMNNGSSSSSSSSPSSSTGDPKNCLVRNLLLNSSGSNPNANNQNSVSQTKNGSSRAFNNDNSGQQSPSPTLTINDNRPMAMTDHHSKNGQKCIIKHLLLKPSSSDKNSKHSAEPTLISTKTTTAMTTTTTTTTLNNLSDSHLPPRKRSRCSVSNPSLNPTCNAQQQLETTIQQPPPPPPPPSQHQLLLSPAMHTCKFCAVPFRQEQNLEIHQKYYCCGGEQQQQQQQKQQVVSDSETSNKHSESIASTTSSITKQQPQQQQQQQQQQQRERKVCVLERPSIISYTAAINRRQDSNNNNDDSNQFSIPSSSASYNFGNILKSKLLSGFNSDNIYDDDGDDDYDDGDETTYHCPRHEKQHSNNDAETRQHSTSSSSIGLKKRKISEPAFRHWSSSRYYDYNNDTKRESAVNEYRDSILQNIQQQQHETLIPAMEIIPAYMPYLMRPPTKITLKGPILFPVLQNLLDTRTNYEFALDNDDKQQQQQQQVTTKDDTKFIVKQKEEIILDEIVRQLMDDMLMELDHGEQMNLLMADLLEAVDRGQQCMELAKKSLQRPTTLALNLNDHQQKQLSNGRKLSILINQCSMIDTNTNHNHNGSTNSVDCGDFGRQIKLMPSTLISPDTPRSQQKYQQLFLDGNAYSNLGLKVSLRPTYCCIYRLQPMYVMQEANPQLSMYSQWATHPVPEGHVLHTLESPCQLLSAYDSNEAVFHHHHNITQTMNRTSSSSLTTVATVNVDNDDQPPTIIVKEEQHQQHKQQPQQQQSTSSSSLSSCKQKGSIQEFLDTVKSRSSHMMNSDVLNHSKTSFTIRLTERTLKTIIWSIDSGIVDRICDSLTRMHYISTHSNYYHHQKQQQQQQQKRKSINQSSWNRSHRKSSRVSFTLVTTTTAPNNMIFGSVNNEENNKTSKVNETTTTAKRKNCSNQSGMTGNISNNPYLTMHPMLGHLPDKQAVMYIMMMSQIPPKLAAPNVQQIMSSTTTNLASRKFSECIGVKQKQFYPHSLYDACNNDHWHRLMASSSTNDDGSLLLPKRIKIFEGGFKSNEDYTYIRGRGRGKYVCGECGIRCKKPSMLKKHIRTHTDLRPYSCRHCSFAFKTKGNLTKHMKSKAHHKKCVELGILPVPTCIDDSQIDLEALAKQEQYELNRPDSNCATNRLLHCSNDDDEFDDDDDDDMFDDDELDDDDQGVPIETQQPKQQPTNRLTYVEPGQFDDAINDDDMLKHSSNAEKKQKTDTNTNNQVETTRQRKISIVESEHHTIPSTLPSIMKSMVEENKNENPPQTPPTTTAMTTVGHNENETEAIHSLLILSSGATASNRDDCPRSSLKQQPNESKLTQNYNKIMQQQPQSSLVASSSLYPATANQRSLSKFMPEFYGYDTALLKPIINDSVDSMKIMINGPSPPLPPPPPPPPPAPAQLQPQSNQYRQPMSHPTSVIITNHQSIQHHAPTVDTSPRKRIRTTSLGDSSMTFETPNIIVSPPEPSPEISSKSPIVLSTIISNECPNANIVHHQSQNNNNNKLLQKIFSSVQQQQPSADSKSIHMMTKQQLVYHGQPLLVRPSSSSSSSSSPSPSPSTNAACSPVALPPIVEQSLNRYVVANNIAESSHSTPQQDEPIDLSSKKSSSNIGASSLNQPQSNNDINRATPEKPTKISSTTKLADHVRQSFSPLSQMEPSSNVVHHIDTTNGGGHQLYQNVRREEFAHLTPGIQSPHSLPRVIMIASNKTSSTGGGGGSQQQQCSPALTNSAMMMKTMAKSPTNYVDGGKPTCPTCMKQFTKPEQLRLHYKIHSFERLFRCESCAVSFRTKGHLQKHARSVSHMNKLNMNITFGRPSVDNPRPFKCSYCKIAFRIHGHLAKHLRSKAHIMKLECLGKLPFGMFAEMERNNINPGLIDTSDCGSALETLQSLAQKLYDPRQMCWNKNVIIDDIDKNNNNNNNNNNDESSSSNGGCNQDDSDSGAITEEYPYGDDDEDHSTSPDQKCNKIATTTTTNTTNNTGTTTMFASSINMAPTTRSSSSTLNGTIAATRSNTCHICFRLFKAAKFLQVHLYSEHADEMNKINNTTTSNTCDTMSHSNGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVC8</accession>
    <name>A0A922HVC8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMME chromosomal region protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AMMECR1L_1</name>
        <name evidence="3" type="ORF">DERF_010169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVC8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.700.20:FF:000001">
        <property type="entry name" value="AMME syndrome candidate gene 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="177"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="386" mass="44748" checksum="511E5AB7F2C20FF5" modified="2023-02-22" version="1">MSNNFKYNNHNHNGNVQQQQNLLQNNINNNHHQSICTNGGGGGGINNKKFRKNEFRRSNLNNHHYYNNNNNNANNHRNHYQSNRLLYNNGHNDNDDDDDDDVANNGDNNDDGNERISTIIKKYPINDNQSTFTNNNNNFNSNSANNNNNKLSKIPKQQTIINIQSLQEQQQSSSSSSSTTSLVASNEMCFFCFDVLYAHLYHKQPPGRPDFTNNSYPLFVTWKIGNEKRLRGCIGTFTAIPLHNGLRDYALSSALRDSRFKPITKDEFNRLHVCVSLLLNFEDGNDYMDWIIGVHGIRIEFRNENGMKRTATYLPEVAIEQNWNHLQTIDSLLRKGGYRGQINEQIRKDIRLTRYTSEKISISYQEYHSFWITQNNDTFMAAKLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVG8</accession>
    <name>A0A922HVG8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVG8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037042047" evidence="1">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6954" checksum="D6ACB0CD9F258BAE" modified="2023-02-22" version="1">MFYTCLIISAILFSRFSGFASCHSNNIFLQVTFYIFNSIELELNQVRCRLLRAALFSPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVI4</accession>
    <name>A0A922HVI4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVI4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7421" checksum="8D51855C792D42A0" modified="2023-02-22" version="1">MTFRSNQMVIFVVRCRHNSRASNNIVHYDDYDDDYLQSSSNRPEFISIQFFVVVVVVVNGCGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWW5</accession>
    <name>A0A922HWW5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWW5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="88" mass="10410" checksum="A3CB86CF7758BC1D" modified="2023-02-22" version="1">MELNKTKQKKIIFQMQKKIKAVMATKMPKKKLKTEKIDAMIIMEKEWMMMVGLKEAHIYEMKNFDYLNLFAILSDPSHHHQILCLKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXT9</accession>
    <name>A0A922HXT9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXT9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="221" mass="25643" checksum="CC16EDB1C0FBD4B5" modified="2023-02-22" version="1">MKKSRRSIKRKSISVDRPLQDEMVKIDDSDSSSQDDNDVDDNELSFTGVGTTKNASSFHLDKQIKRIENKQTSNPILNRLNECLKRIRFSNIRLIQGEMTIKNSTIKMKLKVIKDVIKEFEQFLIETEVIWPLDDHRNLECLPCDKEKNIILNYGEKILLVYGQQLPYPESMFKSGTIIELYPDWFVHRFNNGRQSVSSSSSSSEIKYFILSAFNVLIVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXX7</accession>
    <name>A0A922HXX7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXX7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="273" mass="31658" checksum="B0E97866BBB1C501" modified="2023-02-22" version="1">MVDLLLIHQISSSSSFSSSTMATNTNILFECLQFSPSSTNGSCGQSIPMNRWIIHKTDDLIDVMSHDPDNLIEYVLFLEDEQAQYRLYWPQYVNNGLNANANVFCLHFDYIQSNQCNFNGYHCLINATFTDERININPNITFEYIDSNGWLQMFMQFDLTHQSYIDRPLLTINGQIYRQKSTENIENILKLNTGAYFAIKMIKVLDGKCPQRIDPRKSFWISIMVIFSIMTLSPFIYLIMQKIMEEFRKRNPSSSSNKLNVCYTKKPSHSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYL0</accession>
    <name>A0A922HYL0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pumilio 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PUM2</name>
        <name evidence="8" type="ORF">DERF_007218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="1055"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="1075"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="1111"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="1147"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="1183"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="1219"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="1255"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="1291"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="1330"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="554"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="789"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1428"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="571"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9516483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1462" mass="154953" checksum="9D17A28407E1451F" modified="2023-02-22" version="1">MLNGQSGTATASPAAATSKLVDQTSTTPTKGVSSVNQSSSSNSNNVQSSSSSSSATQQQANNSIDDGVTSPSSSSTTQPKTQDDAMVSYMFQRPPNPGGQDNNSEFGQYAVKSSRWFGGTDETTLIDNNVPSDTQEIEDGFNTLSLDSEGPFASTTKKIWGIEDTPSSKNHADVDPSKVLFTVPDPVHQWGRDSTWSTGPPSTGPTVAENGSGLSEHAVSQPIMVKRAASAYANDGTLLSPRSTDTGGIGMKMAEYVLNNSPSKDNLESRLNSRILHDKQAGGQSARGKNNDKGPHHHPNANGGLANGFGSGNGTDDPTNSIDPAVKLFNRAPGLSHQLSSDDSDELVTGVPKNHLMNKFDGMMAAAAAAAAAGGMPGHHHPAPFADFNPDQLQMHGMDQLHPFSDYIPLSLGPSATADSLMDGYGQTNPALYQQVQHQTRHASGSNNPSTMSILSNHHQQQQHLNMTTAQQQNQAMSSASGGQPSANAANMFAAAATQNPQNPYFPADTFPMSHMALAAAAGPAMSMSQYATAAYGFAPWNMFPTGLMPNAAVPPGATSNGQMQGQSSVGQTGPSSGIQQQQQQSGRSISGAVNRPLSPTSLAVAAAAVHQQQQQQNQSNDGTSGSNSQQQQQQLAALATAAGPLPFPFPGAPSNFFDQLASSRAMPQQAAAHLHRLMTQPQMNMLQTATGNGNMLAAAAAARMLPNAAVSAANPQQNPQSQNNALFAAASTTGPNGNQQQQQMYTSALPNNSAALSLAAAAAAYNNIQSNPQMLNNAHSNNQAAPQLAPQQMGFPNPALGPIGASGLGNNGLGNSNSPRRDSLDNRSSNAAGMGSLGNIFPTMISEASMVFNRHMANALNAAAGPATAAKANGLNNAASFHHPYINSPGPMGLGLPPPGSNMTPPPMDAVNQFGPNAMTGTAPNQAYMNGMRLIPNVGPPPPPDSKFLNRNGMINQQNPFASANLNNTFNNVAAAAAVAAHSSHHALAASLNSSNHLHHFSNGAGIHQQASVNHHQSQANNFILNNTTTSHRSTSGASGGNNQRTRSIEKNVGRSTLLEDFRNSRLPNLTLHDLTDHIVEFSQDQHGSRFIQQKLERASDDEKQLVFNEIIGQAYQLMTDVFGNYVIQKFFEFGTPQQKQALAQTIRGSVLDLALQMYGCRVIQKALESISTEQQKEIVKELDGHVLKCVKDQNGNHVVQKCIECIEPSALQFIINAFQSQVHALSTHPYGCRVIQRILEHCNAEQTASILQELHTHTEALVQDQYGNYVVQHVLEHGRPEDKTKIIMMVRGKVLALSQHKFASNVVERCITQAMRSERSMLIEEVCNYPDNALYTMMKDQYANYVVQKMIEVAESQQRKTLLMRIRPHVSSLRRFTYGKHILAKLEKYMNTGSKSAAAAVSAAVTTSPSSSTTTAAHAAAAISTTTDNNVTASSSSNTVTSTTGTNSSTNGCNNEPVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYN4</accession>
    <name>A0A922HYN4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYN4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="98" mass="10809" checksum="CCFD8889E3D461F4" modified="2023-02-22" version="1">MNKLPEVDIMAINSPPRTSKLISSSTRNFCRLKPQSRRQLDDLSTSYIKSLTTKCGCLANGGDNRRCCCCCSSPLLPLFIVVNVLTLGKPNLRYVNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYP8</accession>
    <name>A0A922HYP8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sodium-dependent glucose transporter 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_010312</name>
        <name evidence="5" type="ORF">HUG17_0290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYP8"/>
    <dbReference type="OrthoDB" id="6365769at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23121:SF9">
        <property type="entry name" value="SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7644752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9511888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="541" mass="59818" checksum="2B1D5187D593E86D" modified="2023-02-22" version="1">MKMSRSYKYIITFSLFFCYFAYGVNFYVVGPTLIELADLFQTSIEQICLIYTVRSAGYTCGSLSGFLFKYINRQLIFVFFMALMGITLAIMPHVTGLTWLFVLAGINGFSIGSFDTAINVWVLEIWAEESGPFMQALHFTYGIGSFVAPLICEPFLSTESIHGGGGHGPPVTGNSVPTTPATLISTENSSIMKIESVVNNSHKMILNLNDTKFHDFLSHIDPVDPIDYLIYIPYAIAGAITVFSALIVLGLYYYKKYEPPTKVRRSQEMKSDKSGVAMLENGLEPPFPCKRSFMDKMPPCLTIWLVSMGSMFLTFFVGMEQMHLQFLPTFAVNTELDLSPSTAAMMSSAAAFAFTIGRCLSIPLAIKLKPQTILYANHFLMLVGTILLAIYANNSETMLWVGNIILGCGFSSVYASIYAFLEQKIRVTNRIGSIFVFAGGLTAAVSPSLVGQYIEANPLILVWFNLACCLLCLTIFVIIHLTVYLQSTKPTKKTFDDGIVVDEELKERQLQLIGSTEIGVVITSITDISDSDLDEKYVAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZF6</accession>
    <name>A0A922HZF6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ankyrin repeat domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_010131</name>
        <name evidence="9" type="ORF">HUG17_0152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZF6"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF52">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="5" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="7" id="KW-1053">Target membrane</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="273"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7644614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9511692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="579" mass="64624" checksum="E86CF552B3ACBCA9" modified="2023-02-22" version="1">MPSRLDNNGTDVVPLMPSLQRLQRELADSIIRQAPLDEIRILLACGAKVNEPVTQGLRPLHYATYQRYEKAVNLLLVRGCDVDAMDDVGYTALHLSAERGYNELMNLLIEHGARVKFTELRPDDKALGNPPRATVADEPLRLAIKNGHLECAEILLKNGADPNARYFLGSEINLISPLNVMCLEMLLKYGAIPDSRDRSGLTPLMKACRHPQGYAAAKILIYHGADVNAITSERHDYRSVLHYAVLSNNIDIVRLLLHHGANARYIFPTATAQKPTPLDFALLSGNVEMVKLLIDAGADVNVGSPIIGRPLHIVLSEKAPNKAELIDLLLEAGADPNAITNDARGPLLKPPIGEYFNATERPQAFIVRKLLKYGAKIVIKAQVHDQIGILKVVNRLDLERDKEVINLVLEAADAFNVAGIKRCSLLNERLRERILQSATRPQPLLHLCRQYIRRVLYEISIQAQANMIQKARSIQCPLYVNRTISENDELNEIESQRLDRMTMDEIDDAFIIGGNGDPERLKLLTILLRRTSIKPSPASQLAGTQVIERIENLLLPDILKRYLNFEISFTSIHELMAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZR3</accession>
    <name>A0A922HZR3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZR3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7711" checksum="5EE23F2EE46542B2" modified="2023-02-22" version="1">MFVDERYKFPGIMYIWTQLFDVGAKSVSVIHGIPLVRFTLFGFSVTSVSLRPVRYVSSVRFFRFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZU3</accession>
    <name>A0A922HZU3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein phosphatase 1 regulatory subunit 14B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_006811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP1 inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZU3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.220">
        <property type="entry name" value="CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008025">
        <property type="entry name" value="CPI-17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036658">
        <property type="entry name" value="CPI-17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188:SF14">
        <property type="entry name" value="GEO07393P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16188">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 INHIBITOR POTENTIATED BY PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05361">
        <property type="entry name" value="PP1_inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81790">
        <property type="entry name" value="Myosin phosphatase inhibitor 17kDa protein, CPI-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9516047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="14235" checksum="8555553190D12E60" modified="2023-02-22" version="1">MSTKTESSSQSKSLHHVNFNTDDNKISAKKKRYLTAKYGQHQMNLIKKRLKVEMWMYEQLQFLFDSDDNLNDIDIDLDEVLDLEGKTRKQWLREKLIDAKKSKELVEKFIVELLEKANTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0X4</accession>
    <name>A0A922I0X4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP binding</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Ras-like protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RASL10B</name>
        <name evidence="3" type="ORF">DERF_008120</name>
        <name evidence="2" type="ORF">HUG17_2370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0X4"/>
    <dbReference type="OrthoDB" id="299781at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052661">
        <property type="entry name" value="Ras-like_GTPase_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46350:SF2">
        <property type="entry name" value="RAS LIKE FAMILY 10 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46350">
        <property type="entry name" value="RAS LIKE FAMILY 10 MEMBER B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7646832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="333" mass="38398" checksum="D76A55CFE26B47BE" modified="2023-02-22" version="1">MPPFVKVCVLGSTGVGKTKLIQQFVYNYYDDQYEATTAVNNKDNIYHCSTMFNGNLYQLKIIDMPAIKEFPTDATTEWSQYQQCQLRNANAYIFCFDLNSPATFNYVKLLRDQLFESRNMQNVPVWIVGTKADLCLNVLAQMRSHHHHHHHHHHHHHHHHHHQQHDHQQHHRHRNVHHHHRSLLHPTSSSQIHSPYEDIQPACKEFSNLIRKQWKCNYLECSAKYNWRVVAIFRELFKTIDPIMVAAASAESSQQQQQQPTSMPITSAPSMASKDQSVSIIKINNATSVNVPPRTMSPGGGDLFQTTTTTSTTTTSRHLAANHNSNRRICHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1S3</accession>
    <name>A0A922I1S3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1S3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="37" mass="4385" checksum="BCDC7AC7605F633B" modified="2023-02-22" version="1">MDDFQIQTVNFVTLIDNNSPFLLYSILVVQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I208</accession>
    <name>A0A922I208_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Importin 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">IPO9</name>
        <name evidence="6" type="ORF">DERF_006743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I208"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="30"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="984"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9515975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1092" mass="124576" checksum="88184ED9C2B97C98" modified="2023-02-22" version="1">MANNGTNLKEIICHNLNQALSMDKNIRENAEQQLNMLETNEDYGLHLMEITLSENLDFSIRHLASVLLNRYIAKHWCDTADKFEPPEVPDPVKQLIRDYLLKSLAIVIADEDNMPTTIRKLLSSFAHSISNIAQYDWPQHWPQLFPMLNQYLISGSQSAIYSSFETHEITDTQIPDVAPVLLPQLLNIFTSRKFAIRTSTNAIKIFGIISETIMVMNELDKNAIKNHLAEFIPRFTEYSIEILMTPETSDTVDIGMKKEVIFILTKLLRYCRKYMKTYLPKILGLIWQHLTTSAQIYVKFKVNSADGDFNDSLSESVDSDGETIGFESLIYTIIDFVNSTFEFAKYRVLIKPVLSDLLYYLLCYVQMTDEQIEKWQSNLDQLIEEDDIDTSAFSLRIAAQDLIMNLARDMTTLNDKHCKKDDELFKIAFLQAIQRHFSEASELEKTQKARQISPQTWWKIIESCLYVMGILSSTIIYTIKSGKNTANEYKSILDNVLLNLNMTESFMAGRSLWTASRFSQIMNDQSLDNFLRITSTLLNTVEAPILRVYALRATYYFFENVQMNQRVSVIKPHLPQFLQGLISIGMNCNSDTLYLILQIIDLLLELDSEFTATVSSSICSISLSSFLRFPDDAIIFDVVLSILDRLFSTDQCFSEIQKRLLPIIVAILHSNPNDPNVSELISNHKIPPQNMAILQPQALDMLTKMINHSNGLNDFMIQKAYPSMINCINKAFKDSSAIFQSGTECLSAFLKKGSDFIARYVDPTTNQNGIILALNICINLLNPHTSDSAASYVGRVIVILIMKSNQIIGHENIQHLLRSTLVRLNTSKELPIMQSLILVFAHLLYTDLSTILVFLNSLPAPDGTKSALEFVMDKWLGIQRYFHGYENKASTVALCRLFQHALQQQANNNQDSNNSGDMNFINLNQIQVSCDDEFDCDSSQTARTRSQTANQNKNVKKRFVPCTLKILKLLINEMVHIREYKAEQNANDEEYDDDDSDDEIDDEDDQYEDLDSSMKIATAKQGQQMIDLTDLLLTDDGHIEDQDDDEILSEEIGNLDLENVLQTFLSEFRHLPMARDFIVHLTPTESDLLGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I287</accession>
    <name>A0A922I287_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_004361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-[protein] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51736"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I287"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10536">
        <property type="entry name" value="SET_SMYD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044421">
        <property type="entry name" value="SMYD4_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="278"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9520666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="795" mass="94051" checksum="DBE413B66DAAE5A2" modified="2023-02-22" version="1">MDFMNFHHHSIINQKDEKSWKQFATFVESIVAFLACNDQTKFLIDWIDEQRQQKTNNEDNILNELNENNEFKMVLSKYFDEYFFENVNIANDLYKNHERALEFFNNVTTKMAEQKWSESLQLISNSIRFCCVNSDDNLLIQLYDKRSIVFYQLKQYHDCIMDIREILANNFNNNNQEKSSMIKFYLRMAQATVNINDQWEDLNMLSNIINDCRSIMDILNEKERTQMEKLLTLMDSILNKKCEELSNRKSNDNDKTKSMNLMDLKIHSPHPIIRGASNKLAITWIDAQTKRGYTAQENIDEGELIFKEKPFVCHFFDHTTDSYCGNCLRRLCNPIFNDSEEKMEEDEDTNDRKPEELSDFEKEYNHFVPCTSCSKFIFCSRKCRDEAYRSFHQRECNHSLIPLESEIGIAYIVVRLVCRSFNSFIELAKKQTTDIIDETNLQQSLDGNYGSIVRLLTHADKHDSDSKTCFLLTAFFLQHVFKRYKMFDDDGDCFYSSIDILKLLIHHLQQMSTNLITIFDQNLDLENIDNCIESPIGIGLYPNLALFNHSCDPDIVPIYNKGSELIFKTIRKISKNKEIFFSYGPTYKTTCVYQRQKLLHEQYFFHCHCMACMEKRENYDSAILCPTCFKPSFIDCLDTTKEKKYFLICQNGHRYDDIEPIKQEILRGIQYQKAGLHFYQLAVDRNDDDDYVAAIISFYKADVIFTNTLQIISSFYKHSIQNEQLPILIMEKIRLIKILRLLIEEIDDDDDELRRLRRELKGLIDYCLNYVELINQNDLKMLREQKQQQQQSALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2J0</accession>
    <name>A0A922I2J0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dual specificity phosphatase-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Dual specificity protein phosphatase 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DUSP14_5</name>
        <name evidence="7" type="ORF">DERF_008118</name>
        <name evidence="6" type="ORF">HUG17_2367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2J0"/>
    <dbReference type="OrthoDB" id="285418at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14514">
        <property type="entry name" value="DUSP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052103">
        <property type="entry name" value="Dual_spec_Phospatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45961:SF6">
        <property type="entry name" value="IP21249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="70"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="134"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7646829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9517442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="294" mass="34101" checksum="4F022EE545A1249C" modified="2023-02-22" version="1">MGVKYSKFEHLKTIDSPLNQAQLMKMTRSGLQINQDVTTKPLNRRTIEKLKQNQKTAPDVLIILSPPFCDVDRITDHLYLTGMGGLTEENLSTLNITCIVNATYEMPLLRMKGIESYRVPVDDDGSEEIILYFDDIANLIDMTSRQNGRTIVHCMAGASRSSTLVIAYLIKFRDYNLRTAFCYVKSLRSCARPNIGFFTQLIAYERYYRKDTSVEIIEIVRKGKKVQVPDFYPTMFPELFKAEVNRQLNKSHMSNIKLQDSHDRNYINPRRKYQDMQRDIQAMIVKNNNMDSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2W0</accession>
    <name>A0A922I2W0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Corticotropin-releasing factor-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Corticotropin-releasing hormone-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_008704</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRF-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2W0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051424">
        <property type="term" value="F:corticotropin-releasing hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051460">
        <property type="term" value="P:negative regulation of corticotropin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008435">
        <property type="entry name" value="CRF-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056178">
        <property type="entry name" value="CRF-BP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056177">
        <property type="entry name" value="CRF-BP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10278">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10278:SF0">
        <property type="entry name" value="CORTICOTROPIN-RELEASING FACTOR-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23541">
        <property type="entry name" value="CRF-BP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05428">
        <property type="entry name" value="CRF-BP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Corticotropin-releasing factor binding protein N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Corticotropin-releasing factor binding protein C-terminal" evidence="11">
        <location>
            <begin position="150"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9518107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="300" mass="34289" checksum="2E4569BE56F243A6" modified="2023-02-22" version="1">MLANENITENIVRLNPKECIFVKTEDGIYTLISEDESNLVCGLYLMASPTQLVEIEFIQFNVSCHKNGLLSVVDGWELMGQFFPSVEDHPIPRDARYHEFCGHIKPKKIFRMSQNVGLIEYRIPTIGQGFTVRIRFIDNPKPCNTIIQGVNYGIYTLRNYGRRINCTMSILFSASFRILSMNVGQSYRRLDSIIHSPRSYAIETGVIKKCKKRGMNDYVEFRGGQGLDTQLMQVGDDVCGFRPFPHKKRFTVMCTNTAVRLVSSGQYDNQIEFGYEPMLDFEPPVNQPASLICPINQQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2Z6</accession>
    <name>A0A922I2Z6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2Z6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="47" mass="5240" checksum="591CD827BE718289" modified="2023-02-22" version="1">MSSTFTVPVIGQNIDLRINNKPTMVIDAKKDEKAISSCLRYSTPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I456</accession>
    <name>A0A922I456_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="1">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_004557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 1">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I456"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="3">
        <location>
            <begin position="223"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9520873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="384" mass="42951" checksum="7BA9D82946746A9C" modified="2023-02-22" version="1">MTTTTTTINHMMMSTTIVVMIMITTTIMTNSTFAISDDQQNNESSNNATGLDKSLNKLLTDLSSLNDRLIRIETIVKEIQQWQHQHHHHHHHNYRDDDQSILINRLQQHESDHHHHHQSIQSQNDDNFESTGIMAATCHMRPNRHLALLNQQDIHGEIYLTQQIATNPAIINMQIRLQGFKVGCDSTTTETNVASLKLNNSDCNAVTTTTTTTTTTTLNEAVGTKNKTFAFGMHIHEGSDLSYDCQSVGNHYNPLNMTHGGPTDSIRHLGDLGNIYADQQGVVSMDNLQFTNLSLNPNDEHCIINRTIVIHNGRDDYGRNTNAASKITGNSGIRIACCLITLLEQRPSKQQQQQQQTTTTTTFPSTIHLSSDDESIQTTTTTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4K4</accession>
    <name>A0A922I4K4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Negative regulation of cellular pH reduction</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BCL2</name>
        <name evidence="6" type="ORF">DERF_007943</name>
        <name evidence="5" type="ORF">HUG17_2236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Bcl-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4K4"/>
    <dbReference type="OrthoDB" id="6021377at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF50">
        <property type="entry name" value="APOPTOSIS REGULATOR CED-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="4">
        <location>
            <begin position="122"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7646698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9517265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="268" mass="29913" checksum="27EFFF8DBAB7CBC1" modified="2023-02-22" version="1">MSLPNTDTLPSTTSTTTTTTMNPTTADHHHHHISHPHVIHNNNNNNNGTNQSTDETIYDPMLMNLVKDFFNAQFELKKAQCPFPSSSSSSSTSSSSNQTSMVNNNTTNQTSINQYSRIRMALRALGKSFEEKYSRQLYDIIVKLELQPQNACATFHCLSNEMFVQGIQWNHIVTYFVFSVDFAYYASQSHAATVNDVARWLTRYTFEHLLPWIEKNGGWDGIVSFAQDIVGDVSNNDNTLFNVDLKNILCGAAGALGVLSLGLFLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4Y4</accession>
    <name>A0A922I4Y4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase C, brain isozyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PKC53E</name>
        <name evidence="8" type="ORF">DERF_005876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4Y4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017158">
        <property type="term" value="P:regulation of calcium ion-dependent exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061669">
        <property type="term" value="P:spontaneous neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20833">
        <property type="entry name" value="C1_cPKC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20836">
        <property type="entry name" value="C1_cPKC_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04026">
        <property type="entry name" value="C2_PKC_alpha_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000012">
        <property type="entry name" value="Kinase C alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000006">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000052">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043566">
        <property type="entry name" value="Rabphilin/DOC2/Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729:SF9">
        <property type="entry name" value="DOUBLE C2-LIKE DOMAIN-CONTAINING PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729">
        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="248"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="6">
        <location>
            <begin position="305"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9522289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="493" mass="54627" checksum="BA91A700DD6D997F" modified="2023-02-22" version="1" fragment="single">MNSSKMSSSPSSSTTILNATNTNYNNNEDKISSPIESNQSIQCVSPPPPLPSSSSSISTSIPTTIITATNETKSPKNNRSRSNSTMLTSSTSSTTSSSTCSISSSSITQQQQQQQSIENDGQSLFTAGSGSSISSGGGGFTRSRGLAARARKGALKKKTIFAVQDHKFLPRFFKQPTFCSHCKDFIWGFGKQGFQCQICSYVVHKRCHEFVAFKCPGVDKGLMATVRGGQQQQQQQQRSGSDRGDRTRHQFQVHTYTSPAFCDHCGSLLYGLIHQGFKCKSCDMNVHKKCQDLVPNLCGCDHTERRGRILLKIYSNDEQNKLICEIKQARNLIPMDPNGLSDPYVKCKLVPDNGHSVKRKTRTIKASLNPEWNETLVFDLKSDDKDRRLLIEIWDWDRTTRNDFMGALSFGVSELLKNPADGWFKLLTQEEGEYYNVPVPAAGEDVRVLLDMRLRSVTSNVTSWQKGDNDTGTGDNISYCSTLDHVTVAMNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I560</accession>
    <name>A0A922I560_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I560"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8042" checksum="7E0B5BED65F84367" modified="2023-02-22" version="1">MADDNDNTNTNTNTNTNNLAQNEFSNYKVRKIFQTSEGGKTSGRVRNNLANELMENVEKEIKSFIQCQPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5G3</accession>
    <name>A0A922I5G3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5G3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9521070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="199" mass="21329" checksum="6D4E162715D3CD69" modified="2023-02-22" version="1">MISTQSIYLLSSCKPISSKIKMLKLFIISAFVAVVYGSYGVAKTSSSLGYNRAAGLGARPQTVAAAIQTRHELNFVHVPTTQNLKPTTIEIGASKLPITILFRSSSSSLNVQQAHDGATGSTQETSSEDEPHRLVHTVKKPIIQELYEIITPIRKISQQVKPVQEEILTVVARNQGGQASSFSGLASTSGIASRGRSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5P5</accession>
    <name>A0A922I5P5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">POC1 centriolar protein A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Wd domain containing protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">POC1A</name>
        <name evidence="5" type="ORF">DERF_005466</name>
        <name evidence="4" type="ORF">HUG17_3533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5P5"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="152"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7639500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9521840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="425" mass="47931" checksum="56C1AFAE2AC4C158" modified="2023-02-22" version="1">MATTTIDIADPTFLKCFQNHRFSINWISFSPNSQYLCSASDDNNAMLWRLDDEQRTNTCYKFVGHKNSVTSVAMTDSFMISVSKDCTARLWRINQDDVSNCSSDSIQYRCHKSPINSVHINMDGSQFCTASDDQTVKVWSTACANKLLFTLSGGHSNWVRHARYSKLNANLLSSCADDGTICIWDIRSKEAAIRLTSKRRSTHFLGVQWHPTCEYIMSSSSSDCLLRIWDLRYEKTIQFYQLHNGIVSSSDFHPNGNYLISSSIDHTCKIIDLLEGRNLFTLKAHTGPVNCAQFSPDGKYFATAGQDHVILLWQSNLSNIDANEHSDNDDDDDDIRSIGFDPTQQMNNAFDVTTKSSSNTMASKKMNGNSSDDLLGEHSLKVTNSVSILKCILQQLETMTDSILQIDQRLTQLEEKFQSISFTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5W3</accession>
    <name>A0A922I5W3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome activator complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PSME3_1</name>
        <name evidence="4" type="ORF">DERF_000102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5W3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008537">
        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.180">
        <property type="entry name" value="Proteasome activator pa28, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009077">
        <property type="entry name" value="Proteasome_activ_PA28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660:SF2">
        <property type="entry name" value="LD45860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660">
        <property type="entry name" value="PROTEASOME REGULATOR PA28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47216">
        <property type="entry name" value="Proteasome activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator PA28 C-terminal" evidence="3">
        <location>
            <begin position="107"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9525982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="263" mass="31745" checksum="9C348C682175D2AD" modified="2023-02-22" version="1">MNNPNEKRLNELKLLYIDFLEMDQISKQFNNYIQRIKNLDQIIFGNISETFRSTNQTDNLIPIPCSIKQVANKIRKTPLDQWPMINPSLQCYRLDKQPLLLMNCNYINTNECIVKLIEQILPVMIDIDKDIDRVHYALQLIMPKLRDGEYVAIDLLEQLMDKIESFQCEIQTAYEWLMSYNERRANRIVNYIRHIHNGDERIILNRFDQDCLIMFHKIIDDLYRWSILIYRLFTINHEQLMEYKNIHGGMTIIDKERFENFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I617</accession>
    <name>A0A922I617_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I617"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="142" mass="15900" checksum="3E3BB63DB4B564DE" modified="2023-02-22" version="1" fragment="single">MSTQRQQRSSSSSSFDEHHHHYNCSSKLSNDYPHMKMAKMKCIKNQSSTNINDNQNHIITNRYNRYTTIDTVNNNLSSSSSSSNYLMSITIQCYLTIMALIFITSSSFITIVDARRSAAEAAKNCHCKKNCKLKNSGSGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I650</accession>
    <name>A0A922I650_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="11">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SMPD1_3</name>
        <name evidence="17" type="ORF">DERF_005091</name>
        <name evidence="16" type="ORF">HUG17_7658</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19254"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="11"/>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I650"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008139">
        <property type="entry name" value="SaposinB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50015">
        <property type="entry name" value="SAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324703" description="Sphingomyelin phosphodiesterase" evidence="14">
        <location>
            <begin position="28"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin B-type" evidence="15">
        <location>
            <begin position="63"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="67"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="70"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="210"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="375"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7637452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9521430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="598" mass="69491" checksum="27C4E7BF8C5AECB5" modified="2023-02-22" version="1">MLPLKKSLVMLSILVSLIIIIDYNVQGMIVPGHDNSVNGWTLSNVTTTNSLKEYNTAMRGKASWLTCQVCSAAVGLIRLYPSLSTVQTIFINVCSLGYEEYRVCEGLSQLFGEELIYILIHSTLSHSEVCGLVIGTSCMPNSARYPYSDKWKLPLLPLSNDVTNVLLDLEHRQKWREENALQVEQNVSTILHLSDLHLDIYYQPNAPAACSEPLCCRATSTANKRSHAAGMWGSMDNCDSVLRTIENLLATISQHHSDQYRYLLLTGDYIPHDIWNTTKDEIVHTTRTFNALIKKHVPSDKIIIPVIGNHESHPVDQFCPEDLNRQFSSQWLYEELLQQWKQWIPSEYHETFRQFGYYAVVDGKARFIVMNMNYCARLNFWNVLRYLDMGDMLHWIQRELQNATLAGQYVYLVGHIAPDEDECFTHWVVTYRNIIETYKNIIRGQFFGHTHLDEIRIYYSNQPNDPEPIGVAYLAPSVTTYLNVMPSFRFYSTDPENGQLIDHMTYYLNLTKANMDDKQFKPFEKYEPIWDFEYNARDSYNMTSLSPKSWHQFIEQVLVNPIYLRRYYQHYGRYNHDQTDTKSISSMINVIDKVFVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I658</accession>
    <name>A0A922I658_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein Hox-A5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HOXA5</name>
        <name evidence="11" type="ORF">DERF_008648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Antp homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I658"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000055">
        <property type="entry name" value="Homeobox protein Hox-A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF6">
        <property type="entry name" value="HOMEOTIC PROTEIN SEX COMBS REDUCED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="349"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="351"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="200"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="286"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9518045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="447" mass="48553" checksum="6F9BCAEBB6C4324D" modified="2023-02-22" version="1" fragment="single">ENYFIDTGTGDTGNISDLTNENNATIITGDIDNNNNTIPITKITGSDPMSSYQFVNSLSSCYGPSRGDNGTAAAAVAADYYSQQMYNSWSSNPSAAAASAAVVAAAAAVGQSPTSSPYTAYLQQNGGGGGPGPAAAAAVCSQQQQQQQTLVGGQQPVVTNNRLANSHHHHHHHQTNNQQQQQQLMQSQLSQLQQQAAVVAATRQSNTSPSSLSCKFGIGDPSQSPQDLSTSSGGAGQSPEPQTPTQPPSSSSSSINIAPSQQQQQQQQSTGSHRINADNQSVTRVNHSNQNSSSSTTGNNGSGATNNNNNNSHNSKFNSNNSNNNSNPPHIYPWMRKVHVGQTGVNSMGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKEHKMQSVIPPQLPQMLGPIDHHHLHHHLHGETKIFSALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6H4</accession>
    <name>A0A922I6H4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6H4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037436472" evidence="1">
        <location>
            <begin position="30"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="275" mass="32217" checksum="84EF8B3FE411840F" modified="2023-02-22" version="1">MFGYGSNPMNTKFLHHMIIVFMIISFNSSNHQTQAACISNETKSKCSMKYAQQIDLYASRLANVGKRGRFLPTNNAELEQFCNETKNMTISMENFMKQCCERELGHVAKIYLYSLRKNSKLLCSKRNNKRLTMITKLFATAPCINRRIRDFQCLAIFKNQTKHIMQYRDDKEKIRRGCWLVHYGDWIECEEKFINDLPCINNDQQREFAVDLLRSSRGDTQRFLCGDFDDTSDQCNHLKKLDPLLFDTKMRMDSRLQSLVFIGLHLLETIGKNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6Q0</accession>
    <name>A0A922I6Q0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_005347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6Q0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037806946" evidence="2">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9521715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="166" mass="19700" checksum="BA1503EFEBE01A11" modified="2023-02-22" version="1">MTTNMVMIIFFFAIWQSHHMMMTTDAALMLTRDDCADLYSMIGANEQQQPENAIEIIRRITQHQMDADSLVRLYDLCLRSEEGIRYRRSMWPQPSSSSSSSRWSFMNRNQHKQHNSIIPSLSTSMNNHHHHHHQHEQQSPLETDSYGQQTTKQEQEQQQQQQQQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6U9</accession>
    <name>A0A922I6U9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6U9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="111" mass="12720" checksum="F2F7A36FA46FDC0A" modified="2023-02-22" version="1">MATTTISFTINDADNAMIDDPFIMIMDQPFLEQNRLKSMYLQDGNDDYGNEESNGGSGGDDGRRRRRRRRPKEGRRRMRNGGGCRCENNNNNNGNIPEMGEFDDNMMMNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7K7</accession>
    <name>A0A922I7K7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">THO complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">THOC7</name>
        <name evidence="7" type="ORF">DERF_000925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7K7"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF5">
        <property type="entry name" value="THO COMPLEX SUBUNIT 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9526867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="264" mass="30022" checksum="8E9CEAEBC37F6C29" modified="2023-02-22" version="1">MMNSTTTTTTMANDSKITSFSNKLLQMINDDEIMKRKLMVDGDGIGDDRKISNLIKQFILWCYNDNESELESELSAERLLNVIDQSELAMAKSVQTIKMITHELDNYENTYKNIEKAIADARAKLSTCKAELAHAKQIRRYKLDYDAIANIIEQHPSTQETQIKLNVLENEIQTLQKINNQIESKLEKRRRQFQLLLSASHQLQSVLDEENTATTTTDHQTSSCLVDNNNDLMTIPPRTLDNDNNLESSSSSTKEASPISMETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7Q4</accession>
    <name>A0A922I7Q4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_006409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7Q4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9522853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="414" mass="48329" checksum="18CB51156CCB674E" modified="2023-02-22" version="1">MQIFQRFLSSFLPLIFYTFYCWLLFGVDHRTMMPMIEMIPMIDQSPSSSSSSSPPELRYENLFYSCQSKGILKRMGQFGNSGGGASGGAGGGAGGGSTLCNRTRLSEELQTYIQYSICLVYNQLPDADKSKRNSGHIRKPPPSSPTTTGTFQVTDDLIEKDFPYHNENRNRNRNNYPRNGGYNDDANRLLDYEQQQQQQNGDHDESIRILWKRYHHNNNQLDQHHHHHHHHHQNQNQKEKRNENNNGNKNPIESIYRQIFEKMTQHLNRLSSMQENYAIGNDTMNGGGPQQQQQQQQHHQQQLYNHLHESERKQRKLKQLNKLERLEQVLHHLKEDIIKKLIYIARCANFEHECQQLKTHTTNNGLTDTAVLSRFHQRYRSVLRNYIEDLKNSLSLIYHAKGSDDNADEITNRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8P0</accession>
    <name>A0A922I8P0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein six6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SIX6</name>
        <name evidence="11" type="ORF">DERF_001464</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8P0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF33">
        <property type="entry name" value="PROTEIN OPTIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="361"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="363"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="581"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="526"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9527452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="648" mass="70348" checksum="F71F6D99731E6C8F" modified="2023-02-22" version="1" fragment="single">GVGTNIESRRRRVSSSPTSSATSSVSSIASSSSNDRHSISSLNNNNHNTNNNIKRKYSSKRTTTITSPKKLQHHHNRTSLIVDNNHSKQSQLITGCCPSPSSSPQLPSSAATSQSSSSSSSLIEKSKTTAPQLSSLSPLSALSSLGGPFGPSQLHGMTALGLGAAALAALSASAMANGAIVGGLAANANVSSQSSSPNSSGNSSSQTSNTSQQQQAAAAAAAAAAAAYGTHPAAAMFMLPTLNFTVGQVAAVCETLEESGDIERLGRFLWSLPVAHPNCAELNKNESVLRARALVAFHAGNFRELYHILENHRFTKGSHSKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRTLLREWYINDPYPNPTKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRQMAQQMHQKMHLQHLSGRNVSGIHHGLHHHHSAFGGHPPSSHHHHHHRNSSLGFNTTPTSISSTTSNGHKNSSLHRFSVDALAGNDSHHHSDTTSSKDYDIDDDDDDDIPLNVTSDDDDDGMSIASWDEDCGDIDDDDDVVDDDIDDRVNDIHHLNHHRNNNDNDDDEDEEIDVGPISPTAVSTTSESSNRGNNNNDNRTLAITTTSTNPTMSLSNKRRKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I915</accession>
    <name>A0A922I915_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I915"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="7198" checksum="C2612AA3F8E38764" modified="2023-02-22" version="1">MSLYGSSSSTSLVLKEFRSYSMEKENMEIQTKYSQYISLYSNLFQSVFFFEQQQQQSERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9F8</accession>
    <name>A0A922I9F8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005449</name>
        <name evidence="1" type="ORF">HUG17_3549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9F8"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7639516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20587" checksum="BA56AFE38DE924BD" modified="2023-02-22" version="1">MDNDNERIQNVLEFWFGKSGDADYLKSRSFWYGSNKTDDDCVRNGLGRDYEDAKNGRLDHWSETSEGALALILLLDQVPRNIHRDTPEAYATDDQALVVAKKVLENGWDSGQPNIIRRYLYSPFNHSETLADQEQSVKLFTEMGDSEHLYWAKNFYNIIKTHGRFPHRDRILRRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB65</accession>
    <name>A0A922IB65_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB65"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="152" mass="17874" checksum="856A93826A3DC5DA" modified="2023-02-22" version="1">MRIIFLDLRNRISFLVTHFSPRSTDDHHNMINYITDHPSIFLHILLIQYYNTILSIHFLYLLILNCLICLSFDWPYKILQINELPSPANAIKFRFKNLPNTVSFPGFLSIRFGLRSSDLVFRKSYKPARFITSIAAQARRTIVLVRFKLVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC36</accession>
    <name>A0A922IC36_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC36"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="76" mass="8768" checksum="9F82961F51E479FE" modified="2023-02-22" version="1">MIIKHYKQAHKPEKKNVINKRNHRGNKTIPTTDCGNMVDYQQQQQQQSSSSTHTTYQKHNISKQPPPPPSTTTNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC45</accession>
    <name>A0A922IC45_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 33A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">VPS33A</name>
        <name evidence="2" type="ORF">DERF_002272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC45"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="625" mass="71918" checksum="32593AF6E05BC787" modified="2023-02-22" version="1">MSHLNSGRLNLSSLRDFQRTDLFALLDSIDGTKAIVWDQQLIAPFELISNIKSFMEHKVIQNLKFRSVQGSMVEAQNVVYFIRPTLSYMDTIAEDIRASESIRNCNFHIIFVPRKCILCEKRLETLGVFGSFTTIEEYSPDFFVLDSDVISIEWPLCFRECNLEMDYSSLYQLAKSLMTLQCAFGIIPSVYGIGRLSKILYDYMNKMKSELISIENNVVSMIDQLILIDRSVDLLSPSITQLTYEGLLDEIYGINQTAIRLPPEKFITNNDDQTTSSAPKKSQVGKFYLNSGDELFKKLRDLYYLRCLRVSAKNLTTQFDERRTAKTVREIKQFVEKIPYLQRLRNQQANHTSMAELIREVTDREEFHERIFCENELLNCFEIDSINPFIETCISRSEDIITVLRLILLQTICANGLKQKTLDYYKREILQTYGYQHLLTLNAMEKCGLLRISNGYGISYSGLRVKFRLTKESSKSNNANVNNGDNQLILYQGQVHDVYFPFTVRIVQHIDQFGYRSFNDAFTRQCKPEPNGQNPYTIFEENQSTGNIRRRRNSDTTSMQSTSETNDKLVLVLFIGGCTFSEISALRLLAQKENVNSEFIIATTSIINGKTLLQSIADPLSTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDL4</accession>
    <name>A0A922IDL4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDL4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="114" mass="12784" checksum="A5ED3014B6D1F3E7" modified="2023-02-22" version="1">MIVFSIRDVITKPNCDKGSNGRQDPDKYKGWPITNSLYKLYVLLQGGCHAKPIMSRMARLITEIGSTKPPDLTLAGLSYHIGIDPDLVIYAMRQTYDYSLPVKRAQTLSVVQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEI1</accession>
    <name>A0A922IEI1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEI1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6983" checksum="6A6A495D2EE8414B" modified="2023-02-22" version="1">MNVKDLNEQRKKNLLLLSLRLHNICHLSFVVHLDGWLVGWPSMANSRFITNILPGICFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEK6</accession>
    <name>A0A922IEK6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GPRDOP2_1</name>
        <name evidence="14" type="ORF">DERF_002541</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEK6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF185">
        <property type="entry name" value="DOPAMINE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="123"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9528615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="416" mass="46240" checksum="35607C07932C179C" modified="2023-02-22" version="1">MNNFNLIKIDDENTTTTTTSVPNRYHQIGMLDNKNDYQSIIISDNNNNSSLLAETILNQFTTTSADFPFNDYLSTTTTTATTIDAQQTNQTIGTTIILEPDLRVHYPGLSILLGIICVIVVFGNGLTMLSICKERYLRTVTNYFVASLAFADCLVGAIVMPFSVVHEVMNKWWIFGQDWCDLWHSFDVLASTASILNLCIISLDRYWAITDPITYPSRMTPRKAFIFILSLWLCSALISFPAIVWWRAVAKKPIEPYRCNFTEDVGYLVFSSIISFYGPLTIMVFTYYRIYVVASEQNRSLKLGVKQIEMSYIGHMNADNIGLSSQQANLLHSNSGSTNNISSNINNNADYYRSNFTLRIHRGGGAAAAAAAAAGSVATATSPTTNTTLSILKKKKNSSKSTTKNNNNNKTIGKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEZ8</accession>
    <name>A0A922IEZ8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZDHHC16</name>
        <name evidence="10" type="ORF">DERF_002060</name>
        <name evidence="9" type="ORF">HUG17_6994</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEZ8"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="142"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7636788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9528089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="363" mass="44151" checksum="49F9350041385721" modified="2023-02-22" version="1">MPKYSIRRLSHKWSLIWNQWKHQLFDRYRLCLLFFKSHFYNSHSDAYYLADTILDPIFYAVDHYLKYCGTIFVLVVFFLLLAFISFAYIIGVPYWYHRSQPVFWIAFVIGHWLLINVIWNYFKSLYTLPGWAIDKPIIIEVTSFCKKCSAAKPPRCHHCSVCNKCILKMDHHCPWLNNCIGHYNHRYFYFFCAYTWLGTIFVMAFGVWVAVDHWFPQFSPFEPIQIQWFDTDYVTNSLVIQFLWLFNRPKWKTKLMVFEAIITVLLFILLGLLLRYHTILVNSGETCIERYINRKCRRHFQRYNRHYQNPYDFGWRENWCRFLGFDRHRHPWRHILLPSNFGPTGNGFTWKTIDDNDFNDEMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFM4</accession>
    <name>A0A922IFM4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GSTK1_1</name>
        <name evidence="7" type="ORF">DERF_002410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFM4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="28"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9528464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="245" mass="28145" checksum="B8E5B28CA8562478" modified="2023-02-22" version="1">MLKMIHLSKMMTISRRMFSTSLSRPTMVEMFYDLASPYTCLQVHLLDRQLGHWKSMDLKMTPVSIAHIMKASSNSPPIKVQAKGRYMFRDLKDLSEYYRIPFALPDIFVDTVFEKGTVKTQRFMMAVHENAPELHDKLIRIAYANFFTTENAVDIANIEEMKKLASKAGCSTDLIAKIEQDMNDDKVKTALKQNTDRVVELGCFGLPITLVHRSDEPLEMSWVFGSDRIHIIGHYLGEKEPPILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGG8</accession>
    <name>A0A922IGG8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGG8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="348" mass="39624" checksum="DDC68B36E1016740" modified="2023-02-22" version="1">MLINIFIGHKTPILARIFIFFIIIIYMVFVSKSFAQDDFGTGDYTDTNGGDDDYDNNGGGEDDYDVDGGGGGDGFEQDPITTTTTTTTTTTRRPITNRPRPQPRPQPRPQPRPQPRPQPRPQPRPQPRPQPRPQPRPQPRPTTQPRPRPRTRPSVTRRPSVTINPVTISTTNLPSSSSSSSPYPTPSTNYYGGVTYGYNGYDPQFNSNPNVGIRPWSDGTYREEDTALNRFIHFFPTLIDDFNNIGRRDSYIDFARFQLNRFIDIFRSRGYDLHNHFYHCTQRVDGCRFVARAMPQTTTTIDPFLFTINPSTISTINFEPLREQIQTSTPTTATTTTVRPKRLRQSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGH1</accession>
    <name>A0A922IGH1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_003195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGH1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037264303" description="LRRCT domain-containing protein" evidence="6">
        <location>
            <begin position="30"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="7">
        <location>
            <begin position="383"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9529304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="638" mass="73656" checksum="9EB0651C30386527" modified="2023-02-22" version="1">MFFPGDLVALTIWIIMILTSTIDKNVVLATFCPPRCKCNEVKLLVFCNETQIDLVPIMLNPQLKELYLHGNRIKNIYSSFIVYQELQYLDLSNNQIGDTGKKSFIMQKKLKVLLLNGNNLTQLNNLSFYGLESLYLLDLSHNHLSEIYSRIFMSLNKLEWLDLSSNQITHINKEAFFGLLNLKRLNLHGNQLKHIPTQSFYHLQSLVALNLSSNRFTHIPEMAFSPLAMLEELIIDSCSISAIHSRAFIHLSNLNYLDLQNNRMANVPTESFSYVTTLRTLNLSNNLITVLKRNAFKNLTHLQTLTISSCPLSQIEKDAFIDNINLNRLVIENNKKLSRIEIGTFEQQHDSLEYLSLRSNMIAFLDWQTINIKRLHYIDLQQNPLACNCSLSWLIAYLKHSNMISQSQKDQVKCYFPNYLYGKKLITLSETDLSCSKLNSTMKTVVNIFTYTAMLILIMTMMIVICRRHKRCLPFCCICRQCRFSSCCCCRNCCSTESSSSSSTTSSPSSSSTIPSSSQPIIVGNHHHHHLLYQRQYYQNQQQYHYSHQQYTDNDDDDGVQNQLPAKSRLENSFYYPTKIINDELTRDKQQIQQQQQQQQKSYHFPYRTGTMTDSTRTSALSVDLHPIPNHSLPISHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IHJ2</accession>
    <name>A0A922IHJ2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RCC1 and BTB domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RCBTB2_4</name>
        <name evidence="2" type="ORF">DERF_004156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IHJ2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF4">
        <property type="entry name" value="PHR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="126"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9530343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="219" mass="24807" checksum="AB1A9B598AFAE611" modified="2023-02-22" version="1">MTKPQQIPLLNDMKIVQVDYGSNFVVILTDNGQVFLASNVEYYWKTNNNLRLINTGNNRFKMIACGQHYLLLLRQDGHVFAMGDNSYGQITGYKKSYESMKHIDKLENVKLIVCGMRHSFSITNKGEIYSWDINNCGQLGLGDQKNRNTPCLVAYPNADLINIRIKDIVAGYQHSLFLFENGQLWGCGSNNHGELGLVLDSRNGKSKLTRPVQNSKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KT15</accession>
    <name>A0A922KT15_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KT15"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="689" mass="78417" checksum="3AB25545925148F4" modified="2023-02-22" version="1">MMAKKNKSKTANNVNDTNNDAYDSVYLNDSYHGNIVDRFHLMSNTFHRLLPFQELIRFSNHSINKVFINYNDEINELNCQILTDLKSMIRQLESSSIDSKINPNITTTVIDTPIKSVGSHKRKYQQNTPSSTNVSKIKDSNKITNKKVKKQKSTDKTLAKLLDKENDNPNKIQTSLIAKKSSIEDSDNKNNDDTNDSRMCLRTRARTRAQNKREQELQQSKNVTEIKNNNNDSTIKKTMAANASILTTPKTRKPRNKNVQQQKESNKKPIVASAAALGTPSAKNINLRKGGGQFPEACVVMATPTLSKQRDEEIRLKSAQKLEKAAQNRKMMMEQRQQKIRQRSIDSHNRLLANQQKQNHQKQQPKLVATNTTPSKQTKAFMIITGAVSSANKDKKNINGNNVFKFGTPVNNLSTKKTASPKSTPTKVLNKNSSNKKLIGDKNMIQMKNIEKTLIKHDNNAINNVEKNDKTIEISPIKPDRDEKKVNVTQTLINSTMTIDKPLSSHPIPPSPMLNKTILNIKEQEKIMTPLKLATTTTTLNQSPLITQYKMTPPPKLEESMISTYDISRYFDSDDEEEQLKEIQQRKNKRLPPWVTGRLFVNRLAKLYCQNEKNSNLAYRIYSNCSKRKIVVDIEKFGLQVIPKYRNRTSSIVWTTTNNKLVPSSSSQLLLPPTSSFYKNFMSEDESTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KUU7</accession>
    <name>A0A922KUU7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_013239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KUU7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="75" mass="8714" checksum="AD8D04182302C59B" modified="2023-02-22" version="1">MKLKSHNTSSQIGQNNGSELHQQHEMTNNNKIYTAAEWTIRMLSFFSIIVILLSFLYGLHNVVKIQKKVNFFSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVA2</accession>
    <name>A0A922KVA2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_013468</name>
        <name evidence="3" type="ORF">HUG17_1143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVA2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7645605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9497476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="113" mass="13125" checksum="12F48D8BFBDE5F43" modified="2023-02-22" version="1">MFVISLYQIWIIFFASSIFLFIFKCVTNEKQKQYKTEYDNEQKAKKSATVVDPKKEQQPQTKNKSPDNLNLTTLESMDSAFRPRSTQEEFLSKNLMSVIPAPGDETIVTKTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KXJ3</accession>
    <name>A0A922KXJ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KXJ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="107" mass="12969" checksum="A4B07779D26F4C94" modified="2023-02-22" version="1">MSKHTSFFDGTQPIWNHNIAEKANKRPAVNRKNFTRITFDPRKRQEKIKNNPVNKINQLMIYHHILLVVLVVILNYNHYCHEKYSTYEQENLRSAFRRVVHVMWLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KXY5</accession>
    <name>A0A922KXY5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_012755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KXY5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000038">
        <property type="entry name" value="Serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258:SF129">
        <property type="entry name" value="LP15124P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24258">
        <property type="entry name" value="SERINE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Peptidase S1" evidence="4">
        <location>
            <begin position="77"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9501949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="397" mass="44627" checksum="EBD3BC2441D6515C" modified="2023-02-22" version="1">MADKCGLLRTCCQRPYNLNSNSIPMIMNDPQQLNIDYIDSVVTPPSMSYNNGGQSIYRPPQQLPPLEHVYHQQPIKAVNLNYHQSSTEFAEYPWQVAILKRIGPSDNLYVCGGALISSSFIITAAHCIKKFQAHDLKIRLGEWDVHREDEFYPYVEKNVEEIFIHPNFVPRNLANDVALLKLDTELDLSQHPHISPICMPQTFESFAGHRCYVAGWGKNAFGHQGEYQSVLMKVDLPVLDSRMCENQLKHTKLGYGFRLDRSMICAGGEPGKDACEGDGGSGLVCESNGIWQVVGLVSWGLGCGQGGIPGVYTNVAHIRNWIDKIVLPYYVNHHNHNHHHHNQIMISKPIPNFNELINERSLNGNSTTEILNNDKTSPVMVTNVNNNNNNNNNKSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYB6</accession>
    <name>A0A922KYB6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYB6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6775" checksum="B8AC40A0262DCEEC" modified="2023-02-22" version="1">MSSPLMDYFNNIGNNLKKNNNKLAFLNTNTSYQRPMTSKMNGKKTNQIATFFLVINLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZ22</accession>
    <name>A0A922KZ22_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_013774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZ22"/>
    <dbReference type="OrthoDB" id="7587145at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41158">
        <property type="entry name" value="AGAP010294-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41158:SF2">
        <property type="entry name" value="AGAP010294-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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            <begin position="23"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="243" mass="27333" checksum="D8A82595DE1B44F2" modified="2023-02-22" version="1">MHSFNLFIFLINFTSILWLTNGQYVQQQLNNSNGHSSSSSSSSSIQQHQQQRQQPQINFSFTNSTSNADNFLDDRNIRLSQDKREILQYLNTKNVVKTMLKLLFGTNEESMVTSRQVLNVFVKMLEVLKSSFGQRARSTSTTSRLRDTMDNAAQAGISMIQGYVKSVLATDKQCIKRSICEGASNAARESRELGNLIAQVGGYATSYMLENQRSLPFGASFEAIRIGRNGADCRKAYKCHEEL</sequence>
</entry>
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    <name>A0A922KZJ3_DERFA</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">HUG17_6456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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            <taxon>Dermatophagoides</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7644094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZJ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7644094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9494069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="100" mass="11488" checksum="A3A3F645A9C051EF" modified="2023-02-22" version="1">MSSPIQNMLILWTILGQINSIMSSSSPWSSVSSLNDCYTLRAMAMNSTIKPKYLLWITIIATGLYELLAIYFLYLIQIVCHSNTAIIEHVDQYLFHSYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L071</accession>
    <name>A0A922L071_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L071"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9510444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="470" mass="56302" checksum="9236DF8A1D86C7FC" modified="2023-02-22" version="1">MFLKIKKFYYCQLEEIMHPKNKKFYLWKHRYETGVMIYYQLRIIICLIIHFTGYSTDYTCYDPICYLVKKYKPNLYHQYLFFMFGLPGLGILGKYVFHFNPTDSWTFQLPYDIVVRNTNHLKQYEYSQTEQENLLRLKYQQNLQKYSSNNHLLGKNLTNWFGWHLTRLSYWFNMEKINKRLAQEKRLRTHLYFSIECRIFICKTYLIIDGIIYQIHMFLGPTVFMFSILYYKIVMNEYHIDKLWQHMILLFEVITIGNMIMTVLQLGFFFLLFASSPTLLKAFQLRDYDRTLLMVVKYCKQLTRMLINDVRMNPKTVKTFVLDRSIYNFLNWFILEHGRICVVTMKAWRGQFIKSFLIYFIISIPWNVLCVTTLILNETLTGSDEFFIYSLTIFHSSLTISLLEALAIQSNSLHRPAKHLVPIIQGINGKNSICMKTKYEDLYSRLICGPRYGPRLAMIGAITHLVIFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L178</accession>
    <name>A0A922L178_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L178"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8417" checksum="EF1B32E144FA3739" modified="2023-02-22" version="1">MVIVNNQLVDSNQTLSCLKGAVTSKKIVEGINFKIIDLKKFILPRRYQRQRCVLNRALRRDRYRMPNAFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L182</accession>
    <name>A0A922L182_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L182"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="124" mass="13525" checksum="B75889E8DC98C081" modified="2023-02-22" version="1">MFGGGNNSFILAQYLSKTISLSLCRYFPVMRAIVTLATYSMTRSNGGELLMAVMAMNEAVEYDFMATAISIKLATNCLQIMGAKPSKPGDVLLLNLVMAFISSRSVTGWNGVSSLRWILDQLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2M7</accession>
    <name>A0A922L2M7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA topoisomerase 2-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TOPBP1_4</name>
        <name evidence="3" type="ORF">DERF_010499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2M7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="76"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9512092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="245" mass="27243" checksum="840B4BED1E011969" modified="2023-02-22" version="1">MKILIPIPVSLFPILCLQKKARIAAINRISIVTTEWIESCWAKYQHEYRLANEESIISKYRLPILHGLNIVFSGLNERDKISNIIESNGGECHSDLITKPIFKNTILLVAEKRGEHYENAQRFNIYQPGTGASRLPRLALRGCLSLTVNKLAFGCAAPLLGTQPKEGTAAPPPAWHPAKGVNFNASCLTVDFYARRFASGFRFGTAGSAMTCVLYLTPLKILRKSNINLSIKQHILTPTCSFLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4D9</accession>
    <name>A0A922L4D9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4D9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="175" mass="20348" checksum="D5F69439FDB45C4C" modified="2023-02-22" version="1">MDRTERPFGFGCKKWTIIVLCMLSLAIKIISAAFILANINKFVDEMHKKEMNITKTQAILLLILFQSITISFTLIGLIGAYKENFCLSLIFSILYSLNLIKVIHDLYHDQNYWFSLIIMAILLTINISFTYDLYCIDHQQQQQQQQSSDNDSMKKKTKNDHHHHHHHSSSSSNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4F5</accession>
    <name>A0A922L4F5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein Rheb</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_011072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4F5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9506334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18667" checksum="62592A1B32893A8A" modified="2023-02-22" version="1">MIQPLKIAFNKNIKVKGQEYSLKLVDTAGQDEYSIFPHEYAMDIHGYCLVYSINNLKSFEVVKVIYDKLLELTGKIQVPIILVGNKVDLHLERCVSAQDGKDLANYMHAQFVEVSAKENSAVTNLFTSLIMAIEKHGLTSCSYKTGANESIVDHNSTSNKHNKCIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4R5</accession>
    <name>A0A922L4R5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4R5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052748">
        <property type="entry name" value="ISR_Activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011:SF1">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="578" mass="67153" checksum="8A5FDD13B0AEDEDB" modified="2023-02-22" version="1">MPFFRCHLPKFDSPKPPFRFDNNSWPTYLRNSIISNEEKQQENDDCLNDEEKSKNKSQKIQIVDRPHQNHWQKLVLNQRCPFFRFHENLTKIKIDQRGSDRKSDENQTKHQFDFDSLNIRLLETFGFIGTALVVGFDIRSRINQWSPAQHRRDHRMLEHISNDNRERLPNFVENGYPLNDFCRTKTIYCGSNRWCNYIFSKIFAMPSFLPSLSSNIVDQIPSTIKINDDDVHGRTDSLVASGVTKTNKKVRNIEELERILCLQPEQNDHTTNCSLFLYNNNENRKSIEKDKDDICITNIVQKNEYPGHLNTDLSLNNYLNCEKASGTVDVSEYNQDDHHSSDDDYDDDSTATASNNNGDFIASVFRQTCLEYSDILNNLSGIQLMKKQRPNDALSCWLSCDTRYSAALFNLGVAYESGLYAMNDDGKPDMDMAFHYYTLAASKGHYNAIYNIALYYLYGKGSIKTNIDHALKLLRIASSKGVQQARDYCQRFDDEKEKLNNQRLINNNKSKSNPSLSSPSYDRFDSDESSLFRSNASNIIIRRSTTLPEFVHYPDHRFRSIDQYENTFHFISFQFLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L545</accession>
    <name>A0A922L545_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SRP54</name>
        <name evidence="18" type="ORF">DERF_008794</name>
        <name evidence="17" type="ORF">HUG17_4839</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L545"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000023">
        <property type="entry name" value="Signal recognition particle 54 kDa protein putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11 15" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="16">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7641794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9518201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="498" mass="54995" checksum="C6D8EFEAF3F4948F" modified="2023-02-22" version="1">MVLADLGRKITTALRSLGNATIINQEVLDGLLKEICTALIESDVNIMLVKKLRENVRRVIDFDEMAAGLNKRRMIMRAVFQELCKLLDPEVKAWQPVKGKTNVIMFVGLQGIGKTTTCTKMAYYYLKKGWKCALVCADTFRAGAFDQLKQNATKARIPFYGSYTESDPVVIASEGVEKFTNENFEIVIVDTSGRHKQESSLFEEMLAIQAAIQPNLVIYVMDASIGQACEAQALAFKSKVDVGAIIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDEFEPFKVRPFISKLLGMGDIEGLIDKVSELKLDDNEELIEKLKHGEFTIRDMYEQLTNIMKMGPFNQILNMIPGFGAELAKCASEAESMSRLKRMMTIMDSMSDSELDSREGAKLFSKQPTRIIRVARGAGVTQREVQELLSQYTKFAAVVKKMGGIKGLFKSGDLAKNVNPAQMAKLNQQMAKMIDPRVLQQMGGMSGLQNMIRQLHTTSHVPGGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5F1</accession>
    <name>A0A922L5F1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_006836</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5F1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="5" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="7" id="KW-1053">Target membrane</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9516074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="417" mass="47322" checksum="777EA0D8ED3B836A" modified="2023-02-22" version="1">MSHEKKSSHQHHHRECEYKMDSDIDIDSKEKTFEGLFDSGYNSNIQSKTFLDLDNEEFDNSSLSNQQQHLDRSQQSNSNRRLPLTQQQTNDANDKNKFDTVQQWSDSGVCITDSGLSIQEDFENYDPIDSNENDQESKQQKIDTQQSHLLANDSNDNKNALELWLKHNSDAETLLHLAIIEGLEDIACSIIKNLSTSNEMLNSFNYLYQNPLHLAILKRQINVIPLLIIKGVSLTFQDNLGNTPLHIACKYSLVDIVEIILATASNKSVSKCFEIRNYDGDTCLHLAAYNNDLKLLELFIRSGAHIDIQEGKSGKTILHWAIENLRVQLVGFLLKNQANIQAETFAGKTPLHFLLKSSIIKQNNQHDSTSSTSLTQSNKSKIYKIIRMSIEYCNEKKLSLDAISHVSDDTDTSENES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5G3</accession>
    <name>A0A922L5G3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Syntaxin-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">STX6</name>
        <name evidence="13" type="ORF">DERF_009222</name>
        <name evidence="12" type="ORF">HUG17_7175</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">trans-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5G3"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21443">
        <property type="entry name" value="SNARE_NTD_STX6_STX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000004">
        <property type="entry name" value="Syntaxin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Syntaxin 6/10/61 N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7636969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9510713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="216" mass="25093" checksum="FE5A8648386EE397" modified="2023-02-22" version="1">MSLEDPFLIVQNEVFDALHKLRNNFTRWTELQSNPSQLSREDYSAFVTELKNGLKSIQWDLDELEESLENSERATTLDGTELTKRKSFIDKTRDEIKSMTEQLTKGNNIFKKVDYTINFGSQQLPKQTKYYRLINEPDSSANTKQVFDDDESHKSPYVPNHSITLDEADHTINVINARPNKLEGIRRLWLNIDDKQKVIAGFTGTAIIVLLVFFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L670</accession>
    <name>A0A922L670_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosducin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_005457</name>
        <name evidence="4" type="ORF">HUG17_3542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L670"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.10">
        <property type="entry name" value="Phosducin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023196">
        <property type="entry name" value="Phosducin_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00677">
        <property type="entry name" value="PHOSDUCIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="38"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7639509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9521831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="285" mass="32499" checksum="9B5A5810DC54D760" modified="2023-02-22" version="1">MSNLDNKLLGEKNHYYCSSSSDDDDDDRSDYREISVQSKIKWEGTSCNTGPKGVIEDFQRYKKFENERRANRVRARLERMKKSASTVKTNVAAMTPATNVTTTAGDLNDLDDENDPFINEYIAKRMKEMLDRYQRSTASKQFGELKHLPSGEAFLKHIDDVQLRTVLIVTHIYNHKIVECNIMNNCLDKLARKYPDVLFCSLDAINVGMSREFTKYGVPALLIYKNGELIGNFVSLGDEFGADFDEKDVEDFLVENNILISSQLISSISVTSNLSKMEKQKQQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L707</accession>
    <name>A0A922L707_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GRB10 interacting GYF protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GIGYF1</name>
        <name evidence="3" type="ORF">DERF_005825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="1159"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="985"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1440"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1542"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1645"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1710"/>
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            <begin position="1768"/>
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            <begin position="1929"/>
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            <begin position="2171"/>
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        <location>
            <begin position="2315"/>
            <end position="2346"/>
        </location>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="1929"/>
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            <begin position="2171"/>
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            <begin position="2334"/>
            <end position="2346"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9522234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2346" mass="258688" checksum="2357D0982AF10535" modified="2023-02-22" version="1">MATTELNFGPEWIRALTDGAGIGSTNSGGGGSNNSSNSGNSGPKTFSGSSGPSSSSSNSLSTTNNTFKSASSKMFNTKSISKHHHHHDIKYRYTKEEMLSYFQQSSFLAPPKDLIQHDEVYVDDGQHPLALIELTNDEIDLMSQNINPDFVLKKSMPNESSSVINNSNNQQNNHSSGSTTTMSNNNQQQQHHGSSYKDRISKLSSSDLLRSPGGGSKLVSSSPSSSNGFITERNNTTNNTNSYPTRGGGGGSSRGSSLNNNRIGRGAGNIVFTRLSSMDSSTSNSDNNNSSAVGGIRSIGALYAGSKKYIELAASGTQRDDDNDKTLLNNTKNNSGSSSMDSSSTDNNNSSAGGAIRSIGTFYVGSKKYVELAATGTQRDDNESTLVNNSKNNNSNSSSNSSSSASLFMPSWRSSTSKTESGTNSNNPEASSTTTTTVKESVSSSWKTNSWRINDNNGSGSRSSVPIRQKDFFGDPIIDDHHDNGISRIKQSTTNNSKSGSGKPFQKRSSFTSSERDRHHLSSFPSVDGSTMLDAERDLFGGRSSSSSSATTTNAGTGSTYSDLFSRNSSSTTTPKGLNSRDRYRGGDHRGCDENNQTNSTKTMDNSKFSHYSSSSKGSGYYGRSYDRFNSRLRSGGGDGNHYHHSNDDSDFFSDRFGTRSNNSGHPHHSQQQQHHQQQQNLSNDDDGDSYRRKDSLPEWSLEDPSCIDVTRVGTFDASGAFHEALDDDLMTPLEVDNDDDGAKNNNDDQNDDEDFFGRKISKTKKNSDNKNHSTTSGKSTEVKSNEPDSNKSEIRPPSTISLSTTTTKTSSKPKPIDYFNDPSLSPNYQTKSDTKQQVLNVDDKTVSKNNDEDNRTTTSMDGNNNNNGSINKNYMMNDENIVGSGGQANSLMSMIAKRNNDSNNTGQSSNNESIGGCMDRNSVFNPTSSSSSGNNSTFSFGGTTSFGPSSAMIEQQQQPASQPVIIGGPISNPRNTVAAHLLDSSSTDNILPGSPSRTVPFKSINRDQNPNNNERNSLFMHDENLLMNDSLKFSSLLNDFNFDFGTTASNSNTNNNSTTTTGTNDSADHQLFMRLASQQQHQQPPPSNNHPFNNQDLDHHQTFDNGSTNNLLNNLANDANGQQRFNIVPSKPKDLIDDPLQQHHHQTQSVSMSTNHTMIKWFYCDPQGQTQGPFTSQEMFEWYNGGYFNPDLLVKRASDSKFTKLGELIQALGGRCPFNLIPPTPSPISVGQPQPIQQPTSVSNNNIQTGRIVMAQQAPPPPPPPTQSIQQQQQPPSSIQHSNFPLRTNNNEALFFPVSSSSTTTSSINNQQQPHSAPIVPPSSMNQFLTSSPSTTQSSTTTIGGGVGHHRGPSIQPPPTQPQPSPSVISSSSTTAAAFQFDDNLMNSFNLFQNLSKNIDTNQLNDDTLLGADHLIEQLIQQQRNQQQQRHAPVDTNVGITQQIPPNHHQQQQHASSSTTTTLSDNHQMRLLLNHLIQQPPNQPQHYATTKDEFLALNTHQQREQYLLDRFEQFNLTSSTANNNLTSPMMKDQLRQVLNEQQQQYHPSHHHHQQQPIQQQQPPTSMGYHHHQHIDDDQLSTASSSGGGGGIIGTGRITAKKLSLDETSTMTANVANARQQMPQPQQQPQLLQRTQSYEPVNFIQQPPQQSIPNHSSYGSDSVVSHGQLSQPVEDPLQLLKKYAASGNENFVPGALSVTDVEEIQRREAEERYHHEQEQKRNQQQRLQQQIVKSDESTAIVMDKYQMMVDTTNDSVANEMEFIEVQRNKHRNQQKQQPNQKLQKIPSTTPCKQHEQTQSSPQPPTKTPPPLQQQPPTSVILPQMPQLPKKAVWGSQSVDNVETQQQPQPQLSIAEIQRLQEEKEKEERRIRQEQQMQMNAAAILAQQQQQRSMKWATQPWQEQQTPVQIKTLTEIQAEEAEKQAALLRQQQQQQQEAMEAAIRRRQDPHSQGVFTPLSVIVAKGSGNQQQPPPGVWNGSPKPVRSGAAWDSGIVADDESQNHPSSQMTAASSQQINYKAAVAAGQKPKIDSLALRQVLKTNPKVKDQSLMMFVRNEIDNPEELYRSSVELLNKHFDNIDAIGFLNIVKDLGSPAEVSEYCQSYLGSNNVSKSFVKFFITRKTYLIKLKQQLEQERNKQSQTVTKKISNWNNAQEHEERVINYKSALSANNNKTSIQSSSSGQSPSNSNGNNHSSAHIKPATLKAQIVNNLNNKSANKGNDDINLMTIQVESMEEFDKWCLDVLRQNFELTIDAETFIGFLKDIASPDEINDYVQTYLGSNKISRDFAKNFITKRSYLRNKARQIEPYEDMCGPAPALTPGGVDNNGFVTVSSSNKKKRSKNKQSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7E3</accession>
    <name>A0A922L7E3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_000150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050350">
        <property type="entry name" value="Compl-Cell_Adhes-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325">
        <property type="entry name" value="COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19325:SF555">
        <property type="entry name" value="HIG-ANCHORING SCAFFOLD PROTEIN, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="293"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="356"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="414"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="472"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="591"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="649"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="776"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="1230"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1352"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1448"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1504"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="8">
        <location>
            <begin position="1568"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="749"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="295"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1387"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1539"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1570"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1599"/>
            <end position="1626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9526031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1644" mass="186412" checksum="54506654EC4AB5D5" modified="2023-02-22" version="1">MLKYIIPSSVSISSSSSSLLQMFRTFQLILIICCIIPLISSSSSSSLSTLDHSQKHYHNNHHHINEHKLHHHRQTDDYSTNIVSHGHSIRYYDDEDDDNNNNKIYKRIRKHSRSSLIDDDSTSLPISGDDHESNIPVSDISVQPELSSSIIDFNYITNGENNNITDHLSTIDGEDDTSITYDDRLCPRDREEAKARGQSCLRKCNSHKDCISSKRRCLCDGLCGWSCIRPDLNCEELPGVANSRYTLTNENFFHSKLIYECDPGFIMSGTGRERICQGDGSWSGWPPQCKTRPVCGTPPFIPHSKHSDLVGTEFELNKTVIYECFNGYEPNGSTEALCVHRNDTVFWSIDLICVRKNCGDPGNIENGYRKISGYVFTSSVNYFCNDGYILAGRALHYCQSDGHWGGELPVCKPVKCSQPKDPQNGRAFYDNYTYGSIVKYQCKSNFKLHGPQNRTCQSNREWSGDEPECKIIDCGQPDPFPNGYIEIQSTTIGSTIYFYCFDGMIFDGQYTNSTCTINGTWNPYPFPKCLAPCSIPQIINGMVENLPPRTKIQHGQPINVTCITNYDLAYQSNPIVCYNGSWSQSPTCVPARCKKLPTRPNNGFVVAPKTEHGMRALFICNDGYILEGPNITYCHFGVWNISSPTCNPIYCQFPGYIENGKVMLVGHMGMYDYPPYVKHVTNNKQIIFECDRGYHIVDGPPGATCVDGQWSPSKLPRCEIYSHPKLLRWNRSVKTLMRYNEELDTNERFEQQQESMIVKSTSSQQQRRRKRHHSKPSCARLPEKNWMTISIVRLGNGNNTYPHGTRIRIACDDGYVTTNPNRTLIKCAKGRWKPELPDCIPAPCITPTVPNARFHLHRRLLQPGELVKHENRIEFICEDGYHEPIPLTNVTLRCSYGSWDSFSSSQICVPKPCRLQRRHLPNGYYLDLTFDTDGTFIEHDSAVLFECLPGFKSNKTGEYRCSFGKIDPELPQCVPENSNNIDHSTPSPQFYNDGSISNRCRSPEKIENALIYFDQLLSQRLTLIGVAQVDHLMSTYDDFNLTNGRNLDYRYVQQSPLPFEYDHGTEIVFRCVTYASKMATKPINNDDESVTANQTTSTRSTWIIRCENGNWIGRSFECENDFIEMEPEEKEELMMLKESNDLNLFHGFSGNGSCMAYTNDSNIRMYNGEQIILNGTFVVHGTAIKISCSDIGRYQLIGSKDRICHNGIWSRSDPYLDKSPTILFRNQLGPIAQSYQGKLIVYPGTILHLDCLWKRKYGTPQWSWKLAQRQYLQYWTTDSSLEYRLTIFHAQESDSGLYTCQTPNLHIHTVEIKVRAIHCPNLNLTTTTTTTTMANNVDYMDDSNDANSTNPTTTSIPTMSTSLLRIAETITNGENNNKMGTIIHFECTLGTILVGQHSIQCLPNGQWSDSIPTCNVTQCYDLTSNLTTIVQRQRNQSDDDVESQTLQRNSPRIESAQIVEINRTIGSKVIFTCPRGYGLKGSNHELECLPSGHWSGSIPYCQEVRCGDPMIPKNGYIEGISMDQQMNVYFAGDIVQYACNDGYMIDGNPISICQENGRWSGPITKCKPSCNYPGLMHGSRLVSEVKFFYEVNETINFECYEGTRVKGNRSIKCISSGRWSGPIPECIPINMNLDQNDDNIDIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7E6</accession>
    <name>A0A922L7E6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Interleukin enhancer-binding factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ILF2_1</name>
        <name evidence="4" type="ORF">DERF_006864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7E6"/>
    <dbReference type="OrthoDB" id="5775647at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052134">
        <property type="entry name" value="ILF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447:SF1">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZF" evidence="3">
        <location>
            <begin position="11"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9516102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="398" mass="46888" checksum="B523A76E6D4CE5D7" modified="2023-02-22" version="1">MEDIPYPYYNQIYVLDHFYLRHNIPMVNDNPINQLEKIYKRTEQISIQTEDRTRIDNFIQNVRNLLGSIILTDQRIKFSRIEEIGPYRKNVMIKQKPFVVHFLALFDEKHLLINHVESIRKIITEKIGQNNNTIYSDLKLDTFNISNAHFIIKSNEFDIKAVILIGLTDIVFRVSTCKMVMNADSLINFNLVKQRLNILQRTDWFLGIATYELRILVKLFQDIKHRFQGFQHFNEWMIEALLNYCLNSQPQIDSKVESMDEINVHHKHRRKFRKESRQKCSKTIKLNQAFLRAFHLLSSGIFLPDSVSICDPLMTTWMPIQNDLDEKLLDLICCTAQTLLRIMNYENGFDFVIGLIQDERNIENVTIWDGIIVQPSISVFIDHSSNTIQPIVNNDHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7V2</accession>
    <name>A0A922L7V2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7V2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="94" mass="10869" checksum="540F1052F5ED03D6" modified="2023-02-22" version="1">MYMYIFFPGCQNSNQKFILALIRRRHLNQINANAIAIIYHVHQSINQSIDNDFFFGSYLLSTTAVMVVVKKIKNNGKQPKKTTNYNTRSSLIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9J7</accession>
    <name>A0A922L9J7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_002351</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9J7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037340862" description="beta-N-acetylhexosaminidase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="212"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9528401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="718" mass="84647" checksum="39CA33D5A8AE3CD0" modified="2023-02-22" version="1">MLLLLLLLLPTIKCHLVSVNPKYPLLEPTLSGPLLWPEPERYLIDKNHQPYRIRLPINFELNNDDEKNRKQLKKCDIIDYNLNKYRYLINNMIEHNKYVVNNDRNCQTETMMMMNDDRKFLNKIEIHIDRIDCDQYPEFVDDTITTTNASSTNHDESYEIKVEAENGKCRIASKTIWGMIRALETFSQLFYMDKQNCMIVIDVVQVWDRPRFRYRSIMIDTARHYLPLWIILQNLDAMAYNKLNILHWHINDDQSFPFKSDLFPNISRLASYSNRHVYTKHDIQNIIKQARIRGIQVIVELNTPAHGHSLAKVFPAIMSGCNNIPVATAAAAAAMETLNNPSSSQKIHSNIINPSCELTYEILEQILNEMHHLFPSNRIHLGMDDVSYECWSNDPNIRQFMGANRMHSFEKLEQYHLERMINITTKLKSKPIIWQDPFDKDIPIPAGTIVQVWKDHRLLDDDPRDWQFHVQKLLRFNHTVILSSCYFLNLIQYGQDWKQIYDCDPHDFDGFDEQQKQKYVIGGEACIWGEYIDQTNFMSRTWPRASAMAERLWSHMNDNSNYDDDVIVHHRLDGHRCRMLARGLPAQPISTGFCEHFDIWPNLMSYSNGEMQTLFDNDFLNNNNNNNNSTKMLQEFLLMAKHEQNMNIEHNYGNNKNHYDDDDDDDVDCSLENNEENNKLIMNHHHHNASDKFTCSLLSPIPLIMIIFYYYVVHLFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9W0</accession>
    <name>A0A922L9W0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9W0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33332">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="537" mass="61844" checksum="13935DF01FCB0057" modified="2023-02-22" version="1">MIKYRTPKYLVQLINAYQNNRRITVSYGGVTCNKTTNRGTVQGSILGPLMWNLVVNDLLCKNFGFDVKIQAYADDVTMVVACDCINYMSIKINKILEMAACWGRKCKLTFSESKTKIMYVSKRIARPIYSPVRMNGSVIDPVKEIKILGIIFDHKLDYRPHIKHVVSKATRVNKSITGIARKSYGLSPAVLRMIYHSITEPILSYGGIVTNKATKQLVTPIAQQATKAYRTSSFISVTALADFPPIELYINFRATVATARVTGKYLYNDQQVQVDINDNHNDDPSKRIITIVREPSVLPPTRIIIKSIKTTRGIGSAYMIVNSTNITRINHFRLPSYCTIQQADLFTMTKIFDWIQANHIHHTIYIVTNNISTVQHIGRRDRKYRQRLANELIDIAMTNVTVSWYKIDKNEQWYQKLKKYAKRTANNRTREYDYQRMPLSYIKKYEQTKMMINWNTMYHRNRFGTNIKQLCPNVHDARKFVPFINKHVTQTITGHGQFGAYLAKFGISNDKKMLLWLQISVGTTSDQRLPIVKPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA88</accession>
    <name>A0A922LA88_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA88"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="88" mass="9442" checksum="F2007D1D61EEA8AC" modified="2023-02-22" version="1">MTDVMMIVAKTVSGKFSKYSDSVDNASKTNDPLGKAPKNEPKILLKPTAIISCVASIRECPDLKAFATATDSIRPTNDRTNMPVPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA91</accession>
    <name>A0A922LA91_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Vesicle-trafficking protein S22b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SEC22B</name>
        <name evidence="18" type="ORF">DERF_002055</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus</location>
            <location evidence="13">cis-Golgi network membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA91"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="16">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="134"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9528083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="213" mass="24854" checksum="1B4E1B82ED8F215A" modified="2023-02-22" version="1">MVLMTMIARISDGLPLAASIQDDETIGRNIVNYQNQAKHLFRKMNVHSPAQMSIETDPFIFHILNDQQVCYLVLCEKSFSRRIAFSYLEDLQRQFQQDYMSRVNKVSRPYSFIEFDNYIQKAKKNFTDSRARRNLNQLNSELQDVQKIMVQNIDDVLQRGLAISDLDNKATNLSVLSQKYKKDARYLNLRATYAKVAAGCVVVFVIFIYFWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAK1</accession>
    <name>A0A922LAK1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAK1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="180" mass="20624" checksum="2EA2C96C0001702F" modified="2023-02-22" version="1">MPLNSSSSSEVEVTSVVCSFDKAFFHCSSSAHVAAAFAFNRWCSHSIEHRKTLQKDMKIVGYRCDWPECEFLTCRKYVMVNHINGKHTNQRPYSCDMRNFTFVKRYFLKAHMYKVHKRRMSLDDRKDQHDMCCTAERAKAARGLVRCTVCTGASAGPGYNTQVMADPAVPNRKPEAKRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAM9</accession>
    <name>A0A922LAM9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-glutamylcyclotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_002590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAM9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061929">
        <property type="term" value="F:gamma-glutamylaminecyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039126">
        <property type="entry name" value="GGACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510:SF4">
        <property type="entry name" value="GAMMA-GLUTAMYLAMINECYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12510">
        <property type="entry name" value="TROPONIN C-AKIN-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639126-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9528669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="174" mass="20217" checksum="9E961586F9D7EB6D" modified="2023-02-22" version="1">MDKLRKSLADDCLEHLVFVYGTLKKSQPNHPVLVESKNGQAKFICNGQTLDRWPLVIASQYNIPYLLYKSDTGHKIQGEIYAIDAEMLKFLDEFEGHPSYYTRRQMPVSTLEHGTIEPWIYFLNQYKLEMLQLPMYADYNSYGQHGLRYVERCDRQGPNANCGHTEKSQVTNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAN4</accession>
    <name>A0A922LAN4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Ran GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RANGAP1</name>
        <name evidence="5" type="ORF">DERF_004933</name>
        <name evidence="4" type="ORF">HUG17_7835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAN4"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.200">
        <property type="entry name" value="Ran-GTPase activating protein 1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036720">
        <property type="entry name" value="RanGAP1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69099">
        <property type="entry name" value="Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7640368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9521260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="525" mass="58837" checksum="BA65D7A4B63677A7" modified="2023-02-22" version="1">MADLTVKSNLSGKKLDSAEDVTDLVEQIRDNEDKIGTLQLDGNSYGVEPLKEIGQSLQTCHNLRHLFLNDMFTSRLKDEIPMALRYLLGGVQASQAQIITLNLNDNAIGPVTMPELLPFLRSEQFTSLRHLYLNNCGLGIKGGTMLATVLSGFENLTELVIGRNRLEIDGIMEISSALTKLTTLERLELPQNGTKEQGIIRLCEALKQNCNLKILNLNDNVLTTTSDDLASSLKKLDKLEVLNLGDCLLKTKGAIIVLSALDSLYREKWCSRIREINLSGNEIGIDAKEMIIATVETILETRENDQTKLKLDLSVNNFGTVIVDELRNHFGSVIDLIIDDDQGSEDEQADDDDDNGCQLEESNQSIDNKTLMNDELDENLLANPEALQEHLNTRYKDLESLCRRFFIVSTDGFNKTEKSLNKHATAEIDALIKVGRKKFLKNESDFILLNTLLAVCGLLKAEDRTKSPRKDADLSGPILALARVSKEFADDVNQKRCIKDLLLEKLKENRYQTLQNEIYSLIYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBP0</accession>
    <name>A0A922LBP0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cheerio / filamin-a/c -like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_005838</name>
        <name evidence="4" type="ORF">HUG17_3240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the filamin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBP0"/>
    <dbReference type="OrthoDB" id="5334309at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="3">
        <location>
            <begin position="99"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7639207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9522250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="188" mass="19879" checksum="E6FC3ED57A85FEC2" modified="2023-02-22" version="1">MSISAHGGGLVNGIAGMENKFTVFTSGKPVSGLTVAFEGPTKPEINFNSTKDGSVDVGYTPKAGGQYKIHIKYEGKEIVGSPFKCNISGDEATHRKLTEKVKVGGPNINAGKVNQDNQLTIDCKEAGITGGISFAMEGPAKVEVSFRNNNDGTITVIYKPPTPGDYKLHLKFNDIHLPGSPYPIVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBZ7</accession>
    <name>A0A922LBZ7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBZ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9530169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7574" checksum="0717DDE3FCC24F5B" modified="2023-02-22" version="1">MVLKTDDDVDESSQPYCDIIVNYYSGCLWLVSSNSLSADFTCWLTVIKIPVILIYFSNDVFISLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDE3</accession>
    <name>A0A922LDE3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">40S ribosomal protein S20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RPS20_1</name>
        <name evidence="12" type="ORF">DERF_002764</name>
        <name evidence="11" type="ORF">HUG17_4876</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 40S small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDE3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000011">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 12" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="10">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7641831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9528850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="119" mass="13313" checksum="0B302CEF84D17F03" modified="2023-02-22" version="1">MATKPEGKGDVEIQQQMNRIRVTLNSPDVKKLEKVCSDLIRAAKDHAVQVNGPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRIIDLKSTSEIVKKITAIGISPGVDIEFTIANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDJ7</accession>
    <name>A0A922LDJ7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PHB2</name>
        <name evidence="9" type="ORF">DERF_003391</name>
        <name evidence="8" type="ORF">HUG17_5347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDJ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="40"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7642302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9529510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="289" mass="32132" checksum="1418D8B7BD9E6016" modified="2023-02-22" version="1">MAEKLGDFMGKFGGKTPSGLGLGAKLLLAAGGLGYAATQSVYTVDGGHRAIIFSRLGGVQQGVYSEGLHFRIPWFQWPIIYDIRSKPQQYSSPTGSKDLQMVNISLRVLARPDALKLPHIYRVLGTDFDERVLPSICNEVLKSVVAKFNASQLITQRQQVSLLVRKQLIDRAKDFHIILDDVSLTELSFGKEYSHAVEAKQVAQQEAQRAQFLVEKAIQEKQQKIVQAEGEAISKNPGYLKLRKIRAAQHIAETISQSQNRVYLDAQSLLLNIASKDFDIKPSEIQGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HGH0</accession>
    <name>A0A922HGH0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tubulin-specific chaperone cofactor E-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_014067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HGH0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9493308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="59549" checksum="5FB807FDE058463D" modified="2023-02-22" version="1">MASTTTTTTASRRSTTTPGTQSIHIANEQQKQQQQQKQQHRINSRMNAGLSIPRSRHHHYRYRRTTLTFVDVLIQRYGVDDVVGQFDDCPFEVFVLGGISPRKSESALLLPPALSLNQCCVKNAGPEPKIRELCHNVEELDLASNNIIDIDEVYKIVRAMPNLRFINLSENDLSKCNRYSSKFIGSSINRQKLEKIKSLVLNNTHIPWSGVELLLNIMPSIVDLHLSLNNYESIQLNAKKSYPNIKFMYLSGNPKLCNWNDIKLLMKTFPKLEGLTMADCNIVSIPEHVLIHLKNLVSLNISNWPINEWSSIDRLNQLPKLIKLRCQGLNVLNKLDTPDERRQHLIARLPRVTRLNGSDISDDERVFAERAFIRWFISNTDELKPPRFYELQNIHGRVEPLAEVNLSPPKYANVRVIFNDLTDEQLENDQLSYESLVRQCKDSRSFKVDLNKSVRNFKVQLSSLYDVIASNIRVFYIDTEMSELLGILHIEELRFAQKKLYTYNVQDGDEFLIEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HH80</accession>
    <name>A0A922HH80_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HH80"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="524" mass="57035" checksum="ED0BEBAF74D4A1E0" modified="2023-02-22" version="1">MANCYKHHEAVIVVDDDVDDDDDDEQHRQHRDGHPNNRSDASSPEQDENRKEENEFGKMPHNAQPSLNESTNLHPVSRNQVVRSDQSGSPPPPSSSTSYYTNDLSAFLSSVPTAIKSPSTSSAGNMAQYQALLQALAQAAPSSSSSPSSSSWMTLPTSWSSMVMTSPSSFMSMLRPMSSPIGGRRSSLTSRLRNIMNAIFYRRENNNTPMMTSGSSYSYSYRPAPYGFGNNNEMAADFSSLGSSPPAYLSSLYNSNGPSAERYVTGSGSKSSMHGAASSYRPSFVAVPSSSSPSFMSAGQWSSPIERPHVSGSMQGLYGRNYGHAAAYHHHYQPQQYHHHQQHQHQQLEQPSYHHRPQSSYVHQPAPHQQSQHYGPSMSESVPSIASAYNGQNGNQWSSPLQSNDRPMQSGQVPISSLDGPFIGPNNAIWSQGQQGSSSSSSNSHQPQQSQSSWSSSNVQDNGGRDVYSDNGSRDEGASYYTSNVFQSRISSSPLSSSSSQFKDQSSSSAMMPSPTYVGPKFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HHQ1</accession>
    <name>A0A922HHQ1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HHQ1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="28" mass="3420" checksum="0C862B1C3DE7C56F" modified="2023-02-22" version="1">MGYSYNPLRFNRPLIPSKVFCHHQQQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKV3</accession>
    <name>A0A922HKV3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">transketolase</fullName>
            <ecNumber evidence="8">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_014051</name>
        <name evidence="15" type="ORF">HUG17_4002</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="8"/>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKV3"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000129">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000033">
        <property type="entry name" value="Transketolase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051424">
        <property type="entry name" value="Transketolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004559">
        <property type="entry name" value="PRK05899.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195:SF1">
        <property type="entry name" value="FI06132P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43195">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="14">
        <location>
            <begin position="314"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7639969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9493292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="623" mass="67973" checksum="96EF6A1B30D3B485" modified="2023-02-22" version="1">MALTKEISQQLQDIANRLRINSIRSTNAAKSGHPTSCASMAEIMAVLFFRTMRYSIDKPRGASNDRFILSKGHAAPILYAAWAESGLFPVEDLLNLRKIDSDLEGHPTPRLNFVDVATGSLGQGLSIAAGMAYVGKYIDKAPYRVYCLIGDGESAEGSIWEALSFASKYKLDNLVAIFDVNRLGQSEPTAFGHDMQLYKARVETFGFNAIVVDGHDVQALVEAFDQASQIKDRPTAVIAQTFKGKGLTDEIEDKVNWHGKPLGDKAEAIIAQIQSRISTPKTTLKPESPIVNVPDVDLSVRLVEPPNYTIGQKVATREAYGTALVKLGKSCPRVIGLDGDTKNSTFSDTYRKTFQDRFIECYIAEQNLVGVAIGAGCRRRTIPFVSTFASFFTRTFDQLRMGAISQANIKCVGSHCGVSIGEDGPSQMALEDLAMFRAIPNSLVFYPSDAVSVERAAELAAQYHGITFIRTSRPATPIIYSNDEIFAVGKAKVVRSSKNDQILLIGACVTLLEAMNAADLLAKNHNIQARIIDPFTIKPIDRETIIKNALEAGGRIITIEDHYPEGGIGEAVAGVIADIPNIVMKRLAIREIPRSGPPSVLIEKYGIDAKTIVKMALEMIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLZ6</accession>
    <name>A0A922HLZ6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial RNA processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FASTKD5</name>
        <name evidence="2" type="ORF">DERF_014321</name>
        <name evidence="1" type="ORF">HUG17_6801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7644439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLZ6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7644439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="658" mass="77910" checksum="FA766498142CC7A0" modified="2023-02-22" version="1">MIVRCFHRRLLYPPSWKSSFILMIGRYKHYGKPTSWSKYFETLEKNIFTNRISQQRPSNMKFIQYENIFAYHVIKLSIPFADHDHNNDISTFKCDLNRFFSSDENGVDDINAKILALNIEQIINLMKSLYHNLPVFTKEDEWNKAFLDSPFSRIWQHLDSLLTNRIEQDWSANKSKYMLISSLWFELGLGQNVCFNKSLMKKLLAEQQLDKSMVLYLMFQANLARNSITALQRRTMIEKIHLFLNENNELTVDELSLIGVGFFKTQTRMPLELLRSYIESCTEQLLQFYPIRSTISIVSILKIIRFSLETIEFNRQKLRTQLNRFVEILGNHPSNFFDSEICLTHLILMLNSILIIDRKLFRQIFARMMANLSIFRIKDIERILFCLANVRFQCPVGQLRRLEQYLCNNDESRLYPNCTYNILLSLFMMGYEPKQLLGRCVNQQQIQDSIASSKMILSTQLLTLDSIMRLRNRKPLLDEKQIEQFQSSLAYLFDNLHTQKGRFIQFIYESLRQQQCDGRNVQLMYLLPFITYPFPVILNKSNFISKLNDDRTFCPFVDSIPYRADYLKRKFFHGSYAILPLMEKDYTVGSSLRGTIHLNKSLLEDLGFRIIPVEHREFRQYFIHHDDDENNTIYSNAKIQSLSLLLFKVQKFIQSKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HM85</accession>
    <name>A0A922HM85_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HM85"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="18456" checksum="7DA2386B4A48575F" modified="2023-02-22" version="1">MKPIVFGEDVLIKSFDCLKYYLLRTEFTIDQYINHQCSINYQTFYRSIWITTLSWIAIIFLSIITFWPSNGFFLKIENFEQKFNVQRIDLSFTCLIIVLLISESTWFISLQKYLKYRYKSINFYVNYLNFDLKRQMERKNQIFYSHFVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNE1</accession>
    <name>A0A922HNE1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNE1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9494287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="13594" checksum="92FBD406941667D8" modified="2023-02-22" version="1">MSNVFSTDNNHHHHHFFYNKDSIIFIILMIVQLTRLLSFKQQTRIIIMIMMMMNKPLQTIMIDFRYFFFLFYFIFQNSNGYLNGSNILLNNEREKKQQQQQRKNTNNDYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPD2</accession>
    <name>A0A922HPD2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPD2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038023702" evidence="2">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="250" mass="28593" checksum="3813AB3D66FD4405" modified="2023-02-22" version="1">MKILLNFSIGIVMIFWRGQNDWQLDNWENHIKVYATQAIIKSSPRCFSSPIMAKSQIDNIDIYLFQDDFKNIDQQFLQSVVSIFSFFNFKKSFRKQFLLMTKDATYAYGEEICSSFSLKHDMSKPQRISLLNDVKIVQVDYGRNFIAILTDDGQVFLASAPKTKWKTKRTLQLISNDNDRFKMIACGCLHLLLLRQDGHVFAMGNNCFGQITGNERLSYETCGGDHSLSITNKGEIYSWGLNSCGQLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPR3</accession>
    <name>A0A922HPR3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dfp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_012292</name>
        <name evidence="3" type="ORF">HUG17_9051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPR3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276902" evidence="2">
        <location>
            <begin position="17"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7637947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9501445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="481" mass="51419" checksum="435E764147730C1E" modified="2023-02-22" version="1">MLKFVVLGLLAIGCFAEESYDKSKKMIGSYSWGSGYQGGKYYAPGFYGAGFGYGARHFGDRSGYGYGHGHGYGHLGYGQWSSYPKQMYYGRYGSGFGLGGGYYNIIPSYHYGAMGGYYAAQPISTAGYVAQPISTAAYVAQPVVHSAGVIASDNVVRTAAIAPSVNFLTERKSDAHQEVVQAAVHQLGRTVEYKSMGHQEHPIQPQIVEVEPSETPLHLHFKTKSSSVSLSQAHEQAPVPQTQISQSSDEPARLIHEIQKPVIQEVREVITPYRQVTQEINPVVEAVHTVVTKAEGQRQNYVAPSTGVSVNREVSHSVNTVAQPVHMGYQHVSVAAQPVATVAQPVATVAQPVATVAQPIAAVAAQPIAAVAAQPIAIGYEEKIVSAPSVASYGVGYAAQPAAAFVESSYEPAKFGYGYDTKYSTSSSSIVPSSSIVPSSSSSFGGYRFGGDAKTFRVGFDNRAGMVGDRHEQYHESRSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPV3</accession>
    <name>A0A922HPV3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPV3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="79" mass="8866" checksum="9D814F139081D052" modified="2023-02-22" version="1" fragment="single">MESSSDVDNNLNKQLDPFWLLVSILVDLVYLRHLSYGQHVPFCSDADHGNDDDDDDGDDDVAVAVVIIVMTKLDYRIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQM0</accession>
    <name>A0A922HQM0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Scavenger receptor class B, member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SCARB2</name>
        <name evidence="9" type="ORF">DERF_012733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQM0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF51">
        <property type="entry name" value="LYSOSOME MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9501924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="553" mass="63693" checksum="1529C41D4297890D" modified="2023-02-22" version="1">MANEIKSNDNNSNQRQQQRMAIILLIITMFGCFLYMKFTDFLVIALQSQLQINGDPNDFTKNWQDPPIPITIDAYIFSIDNPQEFASGHSRAKIREMGPYSYRLAIHKEIVSFEDDNRIVTFFDVQKFYFKNHESHGQLSDRVNVLNFPAYAMANMVRGMIASMPFSFGLNPIVFSLVSLLFLTHGESMIKQNLTAGQLLNGYPFRILDTIDRLAAPLRLFGIELPDTGMPDNKFGFLWTKNGTKNGPYQTYTGQDGTDLLRMVTFKGQYQLDFYDNDECNALNGTEGSTLGLNVHRDRYYYLFTHDLCRSLNVIYQQDTWVNGFHTYRFGPDRNAFAAPRKNPLNRCFCRHMDNENLCDGIFDLSKCLAGAPLAYSFPHFLYAHSDIRTNVENMRPSENRHRAYIDVDPITGSPFNGVDKIQINALLEPIPYLSGYSDVRSTILPLLWMQKSAKIDDKLSGELRLALYPIYAVYIIIYLLFFGGFSLLTIHIARWSYQSYKIRTNRTMMTNVVNTTDEKKPPSRSSSTEPLYQQQQHNHQVFRLIINNNQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQQ9</accession>
    <name>A0A922HQQ9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQQ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9498085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="99" mass="11174" checksum="CE67ED9BEBF2977E" modified="2023-02-22" version="1">MCCPLSQTDRLTCVAIGGVIESSEVETWLLLYLGDMEKSISWTSLKQWNLTLTDVQLCWRFSLLSVGAYSTVPVYPRDERGCSVSLVMSAARFKYQIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRS3</accession>
    <name>A0A922HRS3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRS3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7582" checksum="478A66278485B422" modified="2023-02-22" version="1">MTCWRNAFSVFATILNTYENEKLLNNLVRIRKHDDNFIDIIGFKLNNHKQFDEQLLSATNLDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTE4</accession>
    <name>A0A922HTE4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA topoisomerase</fullName>
            <ecNumber evidence="3 8">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TOP3B</name>
        <name evidence="13" type="ORF">DERF_010655</name>
        <name evidence="12" type="ORF">HUG17_9700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Weakly relaxes negative supercoils and displays a distinct preference for binding single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 8"/>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTE4"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000002">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056452">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23546">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="10">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="11">
        <location>
            <begin position="167"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="819"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="839"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7643009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9505887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="892" mass="100082" checksum="F2574F0A4DF3AFE7" modified="2023-02-22" version="1">MSVLMIAEKPSLAQSLAQILSNGNMTTRKNAACPVHEYKGIFYGQNVLFKFTSVCGHVYTADFERRFKNWDTSDPVGLYSAKIVRVEANPKMKLVNFLQKEARGCRFLVLWLDCDKEGENICFEVIDTISGVMNISFRNPQTVFRAYFSAITQKDILDAFNNLRLPNKLEALSVTARQELDLIVGCSFTRYQTRYFQGKYGDLDSTLVSYGPCQVPTLGFCVQRHDDIESFKPQPYWTMSAVVAPVNFSREYLTMEWMGEPEFNNGKIKQIHNSLKDVRRGKIVSIKKTTKTTGKPKALNTVELLKVASAKLGIGPHTAMQIAERLYTQGYISYPRTETTLYPKNFDFTHVLESQRFNNVWGPDVRDLLSQGFSPPRSGHDAGDHPPITPMKAATPAELGGDGWRVYEYITRHFMATLSTDMIHDVVTVIAEIGSQSFRTSCSELKHPGFTKFLPKGSALNEKSIPSLLKENDEILISEIKINNHVTQAPSYLSEAELISLMEKHGIGTDASIPTHINNICQRNYVKISNGRQLIPTKLGILLVHGYRRIDNDLVSSNIRSDMEKELNQIAKGLADFEIVLQKNIDYYRGKFLRFIETIHLMDELFSKNFTSLVETGKPFSKCGKCKRYMKLIETKPERLVCAICNEAYNLPGNGSIKTYKEVQCPIDDFDLLYFSGQKNFIFCPNCYNNPPFEDMAKSMGCYRCTNDDCSFSMHRNTLGPCHACNYSGQLILDQGSGPNWKFLCNNCTFSMTLFKGASKVAIDRQRCQSCQSNYLMIKYQSEKLRKESGMTDFLGCLWCSPELHNVVEAIQNYSRSFNQSQNGGSGGDRGGYPHHYNGRGGSGRGGNNSRGSRGIGRGGHSSRGGGRGTGRGGYSSRGGGRGSRGRSFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTL8</accession>
    <name>A0A922HTL8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTL8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="7195" checksum="4727ABB1CB39228F" modified="2023-02-22" version="1">MFIIIYYHEHPILMVNIDDHEQQQQLYQQLFFLFLAARGFNSLYQSIADFCIYFKTISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTT9</accession>
    <name>A0A922HTT9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_011808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPOT14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTT9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046890">
        <property type="term" value="P:regulation of lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053719">
        <property type="entry name" value="Lipogen_MT_Stabilize_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009786">
        <property type="entry name" value="Spot_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14315:SF17">
        <property type="entry name" value="MIP21584P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14315">
        <property type="entry name" value="SPOT14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07084">
        <property type="entry name" value="Spot_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9507106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="328" mass="37419" checksum="63F3A659A123B63D" modified="2023-02-22" version="1">MLPLINDDENIIHQHSQQQQHQQQHSSLNSNKSMTKLLQMKMATTTSADAAATATATMAAHTDNGGALLMKQMSIQQHQQHQQFHTNNHIIENFIESVREMNDVVLIPSKLMDLEPKPSSSISNNNSTILNDDLYSYYQMINIIKNDLFDTSHRQQQYPMMNDSNNLFKVPKRKISRHQQHQQQQQQQQQQNHNCNNNHGHGIERSCHSRSVSSTNLASMYHGNGNGINNETRINYQTQLSQTSSNNGHSSPVSASSSDNGIEMNDNTATMMMMMNSTTTTMNECHNARQLTIQFIHHLHSLYSILEHFTQAADIITERYTQEFEQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTW9</accession>
    <name>A0A922HTW9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ARCN1</name>
        <name evidence="15" type="ORF">DERF_011082</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTW9"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="14">
        <location>
            <begin position="274"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9506344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="506" mass="57234" checksum="3DC2339023B1B011" modified="2023-02-22" version="1">MVLLASAVISKQNGKILLSRQFVEMSRSRIEGVLTAFSKLITKDKQHTFIETDTVRYVYQALMDKLYCVLITTKTSNILEDLETLRLFVRVINEYTITSKNHSDEQAISDNAFTLIFAFDEIVALGYRENVNMSQVRTFIEMDSNEERVFEAVRKTQEREAKQKMREKAKELSRLQRTQQNERISKMPGIGSGGMSSNTSSYTGINSSSNAFDNSYDSHKNISSPILSNKPQKPRGPSKALKLGSKNANLFSTEEQLSTELKEEVKPVVKNTAQEQVHINIEEKLNIEVSRDGAVHSSELTGVLHVLIRDEQFCRVKFLVDCEDSENVQIQSHPNVDKELFRQHGLITLKQKAFPLNSSVGVLKYRRTSQSGKDWPPLVLNCWPNGNNCNLELIVNKSLTELSISIPCPSQPTVNECTEGDYSYKRGFLVWDISMISPESKTATIDFDLSSSTTTASAEDFFPINCTFNSTQNLAGLIIKEVLDDEVEDIKWSFESKLNVEKYEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU59</accession>
    <name>A0A922HU59_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU59"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6915" checksum="574ACA1B29C8E371" modified="2023-02-22" version="1">MNGISLQITIRNETNSICHCCGKVLASILFTVHAYYHGKRSKLVIYSPIRFDWMQPDSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUX4</accession>
    <name>A0A922HUX4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUX4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="9057" checksum="DFCDB2A9CABD5AA7" modified="2023-02-22" version="1">MVELNGMDPKPEMKQIESCHITPLNATILYIKMAMDRILAKAKLLNDDDDGGGGGGGPLVVASLSIYIHYTTIYLTITEHLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVD0</accession>
    <name>A0A922HVD0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium homeostasis endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_011409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVD0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056721">
        <property type="entry name" value="DUF7819"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25127">
        <property type="entry name" value="DUF7819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURP motif" evidence="3">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="4">
        <location>
            <begin position="249"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="776"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="791"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="827"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9506690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="99932" checksum="16764BE63001C9A1" modified="2023-02-22" version="1">MNVPKPPEDLELRNIIDKLAQFVARNGPDFEQMTKNKQMGNPKFMFLFGGEYHAYYRFRVASEQQQAFQQHSKMPAQPLPSHAMPPLPNFFPNPPPLPPPLPFPPSSQAPTQFNNNFASQQSPLSHHTHPHHQLPPPHCPPLPLHAPFMSEESFHNHQFVQIPPKTVSNWQPPASTNHLIQSPISAPSSDIESHNRIDSQIQQLKDHLKESEKNLNAQKEVIMGVEMERRINEMITKQLDDELKRMCEDFNINLNEFDKILQPIIKSCRKESVANGKIWIFNHCNTAEQYDAVAKHLLKRVTRTDSQFEGKLHLMYLINDIFNHCMRKNDEKLKTAIVNIIVAAFTTVLMEANDERKQKMNKLLKIWETNQYIDHTLLDQLKSPEQSLDAYKTSLRKKYSEQINMINQEQMNKYIQIEKQHSDFVVHCNNQIQQLQSQKQTIQANMSPIQPSFPPGQMNELPLAPVPAHLPVHPMITTAPPNGTVPPPPTSSIPLVTPSIVNNFVQTNSSMPPDSLQQPQTSLLPPPPHLPLPHARFPAPFSIVTVTSHHQPNFYPTNPGVQMYPPLPLYASAMMPSTTQMLPEVPSLAPEEAAPYFEKPAGLMTTLIKLEDFDYNPIDPKEIKLPSLEPPSERLLQALEAFYSAPTHEHPRNAEGWEKLGLYEFFKTKSQARKEYEINVLGHEPTQKDDETLNDSDSSSMPCNNDNNRKSFSEKSSPPKKSYKEFTEEKSKNRSRSPTDKHRSKKRSRSRSPVRSKSPSKSNHRRESSPKHTFSKNKSSSKSPEFSKFNRNSDDSRKKDLISTKKMTWSNNTGFTTKETKPKVTSPVIQQSEQYRGFGDTTNTPAKMFDPFESFRRNKGQAYIQRIRDARRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW24</accession>
    <name>A0A922HW24_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Coiled-coil domain-containing protein 22 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CCDC22</name>
        <name evidence="6" type="ORF">DERF_011402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW24"/>
    <dbReference type="OrthoDB" id="10266736at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000060">
        <property type="term" value="P:positive regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008530">
        <property type="entry name" value="CCDC22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048348">
        <property type="entry name" value="CCDC22_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048349">
        <property type="entry name" value="CCDC22_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15668:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15668">
        <property type="entry name" value="JM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05667">
        <property type="entry name" value="CCDC22_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21674">
        <property type="entry name" value="CCDC22_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC22 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC22 coiled-coil" evidence="4">
        <location>
            <begin position="333"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="554"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9506683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="606" mass="70077" checksum="0E03521931D7A82F" modified="2023-02-22" version="1">MEEVDSILISQLREIGCDLDDENIHGIVSMDSYQIMKCVAICLRRIQINDDAVDSLIPDPSAINSTMNMSIKYKLANQLSTCIQNIGYKSDIGYQTFLYSNEHEIRRLLLYLVEQISTDSDEKSSSPDHPSATGWSIRPYDIIRRLKHSRPSTVWIPYSSDYIDDDDDESKYCPDSDYHDYYASITSPNSIYGMYNLNNYSLKSFLSSNSNSPLAEYCRINLNKGKMPIIPSTIIDILEWNNHFWKGNTADDDDDNNKNRQVDYMSHYFKTLCESKLTNAIVYHGGGEQSTNYVNSTIPSLMNVGGNVESNEQLSANPATDQIERKTNQQIILDKLRQELYECDSEIHQCKMNENELIRLEKEYQEKYKLFEASFRSKDELENSITTMKDSIEEIAIAWDEMQKDLLEKLRTKKLQNTAQNEAQIEKIRMINTMKKAIASKLKEIQAKESLVKELESRQPQQWPPSRGSYTRRIIEIIQNVKKQNDETLKVVSEMKAVQKDINNLNGKIERSFAIADETLFHEARQNEWNRNCYKSLALLQSSFTELLQAITEIGVHLREIRKLEEMIESENNRKTSANLTRINADLEQIRLENKQLRQKISDASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWH9</accession>
    <name>A0A922HWH9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWH9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="8954" checksum="2C00A599044DB0CB" modified="2023-02-22" version="1">MIRGSKRYCYLSCHYNNVKYRFVVLVMYDMQKKLLISTTTTTFFSMENCRSQKEEANEEKKIEMKMKRKFFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HY76</accession>
    <name>A0A922HY76_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Round spermatid basic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RSBN1</name>
        <name evidence="3" type="ORF">DERF_009907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the round spermatid basic protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HY76"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026306">
        <property type="entry name" value="RSBN1/Dpy-2/CEP530"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13354:SF11">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13354">
        <property type="entry name" value="ROUND SPERMATID BASIC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="684"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="867" mass="98204" checksum="BF32121FBC6829DB" modified="2023-02-22" version="1">MKETSHKFQLQAKSHLSSNSQIKMSPESKNESNSNGRIHQPSSSSPPLPPPAAPPPPPPPSSSLSSSSSSSSCLSTTKKSSKVGPLSYRDRMKRKLSDTSSSSTTAATTTTTTTNAENNDPLYNAFKRMCQQDDSRRMLFRILAQDSSSTQATCSCTTTAANTLIKEFVQRLRCNVGKSENQHDESTSTNDDIDIAPSSSASTLSSSSSSSSLIHKQRKSERDNNNNVHVQTIKLDANDHPHHHQHQHQHQHHHHHHAHRHNSTVCNDNCCNNKTLSNQVKKSNVRIQCKIVQYLATQIRKLPLALSLSLMTPRLPMPAAELQNLRYGKYFRVEQCPNGYAKVLHLYWDEIAHLDRQQKLELAAEYMKESFREVKPNVSAYVISIIHNAAYYMPDWLEWLSDTNPNLAVKAGKLGQSGSDIETTTMTKYRQQVHKTYLNGTYRYGPLHQVSVVGTVHEEVGGYFPRLISILEKSPFLRLVMPWGPMSSLQHMSSPTESNDGPILWVRPGEQLIPTACLSSNSSSSNTPTKRQNQLRGLLRRSSEPREFMFEDRTKAHADQVGEGLERQTTAAVGVLKAIHCGQQPKYNRVTKDVVAFDAAHFDELTMKLQLDLYEPPVSQCITWIEDAKLNQLRREGVTYARVQLHDNDIYFLPRNIIHQFRTITAVTSIAWHVRLKSYYRDSVSAKHDKTDDNQAKDQSSHSNNRHQQQQRKHSITKKSNPNNKQRSDKQEESSSQDGKPVPNKRARIAYSTAAAADDDDDDDDDRREIDDAKTADLKSKIQEEDSENNGQFRKRRHSATTPEQNRLPFDKQRVHSEPPCIRKCKSRKQLVMKFLRQNSIIKQEQSSSQGPNDRKRKCLDDQHCCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HY87</accession>
    <name>A0A922HY87_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HY87"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="119" mass="14015" checksum="C0C800B51B2C0CB9" modified="2023-02-22" version="1">MYFRLINCFADIQTFGIANIWITLTSELIVEYISSYGALLKSNKITQENCALISKLTRCVYVYQRNFTWKQKTYSFAILIIVFDLSITEYNSLQNKIYQARIADPAGKYHRFYILLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYX8</accession>
    <name>A0A922HYX8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_006690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYX8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF83">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037551505" description="Alpha-galactosidase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9515917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="859" mass="99786" checksum="D3696A7F8CA5683E" modified="2023-02-22" version="1">MMRNLSNVLLLLIISLSSCLMVFGWDNGLARTPPMGWLSWMRFTCEIDCNTYPDECINEKLYKDMIDRIVDDGYLQAGYQYVNIDDCWMAMDRDPKTSRLIANETRFPSGIKALAEYAHSKNVLLGIYEDIGTLTCAKYPGTYYQNKDHTFIDAETFSEWKIDSVKVDGCYADPKKFNITYVEYSKALSQVEHKILYGCSWPFFKADFSENDYKLIRKSCNLWRQFGDIVDSYQSVKWIIDMMGMHNERFIRYHGPGGWFDPDMLIIGNNGLSYEQSKTQMAFWCMWSAPLFMSNDLRSIRPEMKEILLNKELIAIDQDPLGIMARKITINSQTHQIWVKKLSTSNDHLPNPFAVLYFNSEQLGSPKYMSYRLSSLIPELNQTISYDVYDLYAKSNESYLETLKADQNLRLKVPTAGSVRIWQFKSLIVMMMMTTTTKFLICFLFSFTFTTFVYGWNNGLSRRPPMGWLSWMRFACEIDCKHYPNDCIDEKLYKDMIDRIAEDGYLQAGYQYVNIDDCWNAHYRDPKTLRLIANQTRFPSGIKTLAKYAHSKKVLLGIYEDVGTLTCGGYPGTYYNNIDHTYIDAETFSEWSIDSLKLDGCYADTNKFNLTYPEYTLALTNVQHPIIYSCSWPAYLKNISDETYSEIRDNCNLWRNYNDIVDSYQSVFQIIKYYGQNNKQFIRYHGPGGWFDPDMLIIGNNGLSYEQSKTQMAFWCMWSVPLLMSNDLRSIRPEMKEILLNKELIAIDQDPLGIMASLVIQKSNWQTQVWTKKLSPMNNNELNPWAILYFNGHQLGPDSYMSYKLSSLIPELNQTISYDVHDLFNSNDSYLGTLKPNQQLELLVPTAGSVRLVKLIPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYY7</accession>
    <name>A0A922HYY7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ASF1 anti-silencing function 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Histone chaperone asf1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ASF1A</name>
        <name evidence="9" type="ORF">DERF_006704</name>
        <name evidence="8" type="ORF">HUG17_1281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYY7"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7645743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9515932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="246" mass="27679" checksum="496F4469FAFE2FFF" modified="2023-02-22" version="1">MAKAQIVNIVVLDNPSLFFNPFQFEITFECIEDLKDDLEWKIIYVGSAESEDYDQVLDTVFVGPVPEGRHMFVFQANAPDPSKIPVADAVGVTVVLLTCSYRSKEFVRVGYYVNNEYMNPELRENPPSVPQFEKLQRNILATDPRITKFKIDWGDDVDDDVNDNIGNNGGNNENNSFERCSTTNGTYKTMMEKCGFLEPSSNVNGTTITTTKSDMNNSNCFISEDSIGPLNPVSLQQQQQDNPMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ06</accession>
    <name>A0A922HZ06_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_007445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ06"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019346">
        <property type="entry name" value="Ribosomal_mL42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13450:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13450">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10210">
        <property type="entry name" value="MRP-S32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9516723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="133" mass="15882" checksum="8F568592287E268C" modified="2023-02-22" version="1">MNSKWIRIRHLLFNINHKNNQKGVIQRYLSTKNSDDPRITLTDDGKTIVCWHPEQSFPYEHSLPYDDESIRLNTSSALKVETMEKGENIYHKMPVNRLEMEELRAITYTNKHNWKRRRMEGLQLRPAHPRKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZJ7</accession>
    <name>A0A922HZJ7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZJ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="354" mass="40725" checksum="2C7325CA189B5AA0" modified="2023-02-22" version="1">MLNFKSIHLIWIGFFLLVSIRMFVESESSTSQHRNKYDFKKLLECFNNECLNEICVTSQGYIGLQTQKLSPGIFDEIDGEFFENHQSIEERSYAGKSCVSVVYQITSMPKIAINQLTTVHGDHVMNLIPDTVQYNAGDYRIKIKRSSDIMQYKIVMNLRNVSGSNAFIKFDNYETYHEKIKLSEFVGTTLHSFKKNNKYPYFHCTASKACTQLFRKNYDIFQSLSFGSGDRSELHNDWQYDSCFEKLSSITMVQKSPNDFQMNGSESFGMCSGSYIRFLDSLALAGGDSTNCIAGNSLNEKFEEKKLTRKYEYKVNLVRAEININDPQSYFKLKIIKPNGSDVEPYVLEPVDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0P1</accession>
    <name>A0A922I0P1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G elongation factor, mitochondrial 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GFM2</name>
        <name evidence="6" type="ORF">DERF_010150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0P1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="33"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9511711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="823" mass="94295" checksum="E2CD8CCD057B0040" modified="2023-02-22" version="1">MLPSIFVIKKSSSLIFDPRWKMVIRHLSSETTKRIRNIGLVAHIDAGKTTTTERMLYYSGSSSQMGEVHHGDTVMDYMDQERERGITITMAAATIQWLKHHINIIDTPGHVDFTFEVERSLSVLDGAVVVLDSAAGVQAQTIKIWRQVQRFHIPGLFYANKMDKSNASLDRCLQSLKQKLHIEPLLLQLPVQKQGILTGIIDLINGNYLQWPLDHYDRLDLDHNSAQIQRHCLLSNELSTKCLTLDEHQKYRDEMYRERECLISKLSDFDETLADHVLSLDQIHRINPIELMKSIRKSCLKRQLFPLLIGSSYRNIGIQPLLDAICDYLPEPMETRTNQILHEHYTRNHTKPTSTTNLCALAFKIHYHQRLGLLTYLRIYSGSLTPGMNVYNLNRQSMEKITKIYRPFADHFREITATTVTSNHYHQNPKTIRESISNNMITIGDIIAVSGLSNTITGDTLIHTMHENDHDINNEIPMLAGIEIPEPVYYCSLECPSVSKFKQLELALDHLQREDPSLHVNHDQNTQQLIIKGMGELHIEIIKDRIKREYGIQVETGPLQVSYRETITKNHRETMEQTKIIGGHSNQMKISCEVRSKLSSLDNKHNVLLLSENIDQNENDLNHMENIKRKAETIVKIVNSKDHNLSSQIRPWQLKAIYSGVSKAMEYGPLFSFPVVDVQILLHEFEINSSSPLLSPFITNVTSHCILEALRQSKPILMEPIMLVEIITPEQFIGPIISDLTIRRSRLMAADNNQQQQQQSSETEQIEERHILAQVPLAELFNYSTTLRTITSGMATFDLRLHSYRPLDSEQTANVIKLISGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0R3</accession>
    <name>A0A922I0R3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="6">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">VHA55</name>
        <name evidence="11" type="ORF">DERF_007587</name>
        <name evidence="10" type="ORF">HUG17_1952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Essential for the proper assembly and activity of V-ATPase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0R3"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="158"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="389"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7646414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9516870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="504" mass="55544" checksum="ADF771576A2036C6" modified="2023-02-22" version="1">MTVNEWLNPNAANRTHAMAVTRNYISQPRLTYKTVTGVNGPLVVLDDVKFPKFAEIVHLTLNDGTVRTGQVLEVSGSKAVVQVFEGTSGIDAKHTVCEFTGDILRTPVSEDMLGRVFNGSGKPIDNGPPVLAEDYLDIEGQPINPESRIYPEEMIQTGISAIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQGGLVKLDGRGRESDDNFAIVFAAMGVNMETARFFKQDFEENGSMENVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLSNRQVYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTAEDLLYLEFLSKFEKTFITQGSYENRTVFESLDIGWKLLRIFPKEMLKRIPADTLAEFYPRQGGGGGGAQATGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0U4</accession>
    <name>A0A922I0U4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0U4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="94" mass="10292" checksum="A3A99288AB2DD848" modified="2023-02-22" version="1">MLQEKLLAAQFGSSRTSSYFYFLHLFLPFLNPKLLKSVVWIIDDDDDSSGGGVVVAGAGGGGGVGGGYQKDNEPELCLYIFVCMNVLRERQKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0Y2</accession>
    <name>A0A922I0Y2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0Y2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="8074" checksum="FEED3FD4FAB2604C" modified="2023-02-22" version="1">MPSFIYEKRYSFQPIQNDDKRHNVNVPLLTALHVVIRSDTFYTDCLMLLKYGDVGGVRPGLDVIVEAYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0Z2</accession>
    <name>A0A922I0Z2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_004196</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sarcoglycan beta/delta/gamma/zeta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0Z2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016012">
        <property type="term" value="C:sarcoglycan complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006875">
        <property type="entry name" value="Sarcoglycan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039972">
        <property type="entry name" value="Sarcoglycan_gamma/delta/zeta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12939:SF10">
        <property type="entry name" value="EG:4F1.1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12939">
        <property type="entry name" value="SARCOGLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04790">
        <property type="entry name" value="Sarcoglycan_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9520492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="324" mass="36559" checksum="33B695CC1FA798AE" modified="2023-02-22" version="1">MNQPTILTANQRPQSQRSVYSFLFVQWSTMQQYSTILFALTLMVTLNLSLLVWLLSQLNFELDNDSYLPLIGSVRVDGQLSVQRLASPIDSSELRVQSADLEMRPHQWSSSMAALALTSDSMLAKVGEMITVRSSHNDRLLMLIDHQTPASSKLFVDQVVMRSTPALQNRALSMKNGSAQVMQLQSVHNSTSSSLMLTSYTNHIRLRGTRHLTINSQNHSVRMNSRQVAIAIHSGHGRIMINTTRIQLNSQAIRTVVPTKLGRTYLTVGQLCLCENNGRLFMAPADQQHHYSQHSWIGHMNQLEQRCQRLAAVECWASQWTKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I125</accession>
    <name>A0A922I125_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA binding domain containing 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ACBD5</name>
        <name evidence="6" type="ORF">DERF_008482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I125"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF77">
        <property type="entry name" value="LD25952P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="5">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9517863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="368" mass="41996" checksum="FE90D8B9EE97BC4B" modified="2023-02-22" version="1">MSIEEQFDAAVKVIQSLPKDGFFQPSNEMRLRFYAFFKQATEGPNTTKKPAFYDIINRYKWDAWTKCGQMSRTEAMLLYVDELKKVIETISMTHEVSEFLDLLGPFYEFLPDDMTNGKTNNGSTSADTTTTTATTTTNTMTKKVNGENIGQNQIATTTIINNNHNHHVEQENFTITYDSDGDEFTDTIDSSFSPQHQQVPKIFCNTFNDDDHDDDSIINAHHHSNNNMNNQNMSSLVGEKNSSIINNRSESKTINQSSSSVAAAAAAPPNVLLDFNEQLAVAIFQLQNSLDRITNRVHKLEQQQQQQQQQVTIRQQQQQSSISGINDNNQNNNGWPFRELRPQTTLFILTWPMAVFFLLNYLQRIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1G7</accession>
    <name>A0A922I1G7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_007522</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Sec) + L-serine + ATP = L-seryl-tRNA(Sec) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ser) + L-serine + ATP = L-seryl-tRNA(Ser) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1G7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.40:FF:000002">
        <property type="entry name" value="Serine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="179"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="311"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="327"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="398"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="11">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9516803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="479" mass="55028" checksum="2B1D85E1588B5FB1" modified="2023-02-22" version="1">MVLDLDLFREDKGGDPEKIRTIVRNRFADVGAVDEVILLDKQWRQARFNMDQLNKSKNKISKEYGNKVKQMKQQGIKEENKASQQNQQGDDGAKVFSAEELLASINEIDANTTLEQLKRLKKQVDDKIVTFTDEVNQLEENRNSILREIGNILHPDVPVSNNEEENAVIRTFGQFETKELSHIDLIQKIDGMDCDHGADIAGSRGYFLRGLGVFLQQAMIQYALNFLYNKDYIPLYTPFWMKKSLMSAVAQLNQFDEELYKVVSSKQNLEDTDEKYLIATSEQPLCAIHRNEWMNPQSLPIKYAGYSTCFRQEVGAHGRDTRGIFRVHQFEKVEQFIICAPSKSWEHFHEMISNSEEFYKSLGLSYRVVSIVSGALNNAAAMKYDLEAWFPGSKAFRELVSVSNCTDYQSRRLQIRFGQTKKMSGPVEFVHMLNGTMCAITRAICVLLETHQTSEGINIPEPLQKYMPEKYSKFIPFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2H7</accession>
    <name>A0A922I2H7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xaa-Pro aminopeptidase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">XPNPEP3</name>
        <name evidence="9" type="ORF">DERF_008006</name>
        <name evidence="8" type="ORF">HUG17_2290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2H7"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="131"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="316"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7646752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9517328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="589" mass="68084" checksum="96C33517F6C520AC" modified="2023-02-22" version="1">MAQLHRYYRQRFFNLFQQKSFHHHRASLLQCRNLNLVINYNDINIKRRIHTSGILLSSNDTLYQHEHDISRSFIMPQQQTNDQIISSLNDTAYVSFISHQEIRDRQQNLMLLACEHLRKIQPSFKNLSPLILIATPPPQYQGNTKIPVNECKQNTDFTYLTGLHSGTSDQLTSNCVLAIFLENPDCIDSCRSIIFSSNRTKSEKQWHGPELNVQYELWLKQICDDCQPLTELVNFINKHIKPYRRDMFISRKTLEYRPELVTHLKFYLKSSTTSFDKEMEKWSTSLGQTIQSVNIRDISLFIDQLRVIKSSQEVKAMKRVGHIGALALTNTIEWSRRLFSTTNTNDNPSFTFIESHIDAKFNFESKLLGARHQSFPSVCASGPRATIIHYGRNDHIITRNDNDNCWILTDVGCEDVDGYCCDISRTWPIDMNRNSIKNDKFQLQSQLYEALIGIQHELVNSITIGHTSLNDLNQLMLNIMARILPEFNMFDESVSNDDVRNIIKRLCPHHVSHYLGLDIHDTPSVSRSLPLLPGMCFTIEPGLYFPAQGLPIKEEFRNIGIRIEDDIIIEPGTKMIIPLTNDCPKLLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2R8</accession>
    <name>A0A922I2R8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_007678</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2R8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF47">
        <property type="entry name" value="N-ACETYLGALACTOSAMINE-6-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9516976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="492" mass="56273" checksum="C7395B07124942B5" modified="2023-02-22" version="1">MLMDDMGWGDLGVNGDPSRETPYLDRLAAEGMQFTDFYAGSPLCSPSRAALLTGRLPIRNGFYTTNIHARNSYIPQEMVGGISRSEILISELLAKTNYRNKIIGKWHLGHSKSEYYPWNRGFHEFFGSFGIHSNPHDNVKMPNVPLFRNDKMIGRYYENILIDRKNQQSDILKNFTQEAIEFIQQESAKGNPFFLYWTPDTLHAPTYRSAEFVGRSMKNSSYGDALIQMDHSIQAIIETIRNEPCLQNNTFVFFTSDNGPALTSRADAGRNGPFLCGKQTTFEGGFREPAIAWWPTKIAPGTINRHISTHMDLFLTIATIAQISVPDDRHYDSNDLTKVMFNSSHENQNASMFYYRGDTLMAIRHGSYKAHYWTFSTPPEELRVGINFCPGQNVVNLTTSQLTNHTELPLLFHLYRDPAERFAINPKTKEYKENIKILNKIRDEHQRQLKPGKPELNYCDQAVMSWSPPGCETINMCLPIPKSSPYLCEWPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I356</accession>
    <name>A0A922I356_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">lysozyme</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_007863</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I356"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16890">
        <property type="entry name" value="lyz_i"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008597">
        <property type="entry name" value="Invert_lysozyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11195">
        <property type="entry name" value="DESTABILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11195:SF13">
        <property type="entry name" value="INVERTEBRATE-TYPE LYSOZYME 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05497">
        <property type="entry name" value="Destabilase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51909">
        <property type="entry name" value="LYSOZYME_I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="3" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="4" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037803815" description="lysozyme" evidence="11">
        <location>
            <begin position="18"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="611"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="642"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="683"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="736"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR608597-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9517171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="800" mass="88827" checksum="5BE3AA618B3EDAB5" modified="2023-02-22" version="1" fragment="single">LQIILYAIILWINVSRSLEPDRHCLDCICHASTGCKRNIQCHNSGNGQYYCGPYQISWAYWADSGKPGDAGFANDFEQCLVKKSCSEAAVRGYMKKYANDCNGDGHVDCFDYAAIHKVGPSGSCQPSWLINSKYWIEFQQCYSQSPSSSTASSFRDNSNLPSNTMIEVPRNKPLLPFLPPLPPPLILPPVHARASASVPGASATASAAAGFDSNTGNPLTFVSSSTGNGNNDEISIETFPPLPALPGRFGPSNRPNQIPPIPGVLVNKPQPSTPVLVSSVNFDRMKPIRFDLPETRNPLSSSSTEREDHDSPIINSVSNVEEQPEEIVATVTNEEISYNCLQCLCYASSKCDVNKGCEGAYCGPYLLSWGYWADGGKPENEYATCSKQKSCSENAIQGYMAKWKRDCNHDGKIDCIDFALIHKLGPHGCEKIQALKSTDYWNQFSQCFNLPSENENKPVRSTGPVLVEIPKPQPIISTRSSEPFIGPIPNNPNEDESNNYETQPQPRGVVIRVNNRDLINTNNNNNNLRAPPTRSRLPTRIDLGTLNTSQPIIIRIKPPTNSNDPRRINIPETRPPPPPPRPSSLQPKPIEIIEEQPPTIIEPSRRPIIHENDDFFSQPRPFDQPSSRNEEPNVSEIRRQPPLSPKPSPPPPPPSSPSRPKPPVRQNATTDSLVTLECLECICYASSKCNPSIGCRSEGTGKYVCGSYQVDWEYWMEAGKPGNRADLSNVENFQMCMNNRECADKTVTEYLKRFRKDCNEDGHIDCNDLAALHIGGPKHCGAQWYLDSKYYSDFRECFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3W8</accession>
    <name>A0A922I3W8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">T-lymphoma invasion and metastasis-inducing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIAM1_1</name>
        <name evidence="7" type="ORF">DERF_005239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055230">
        <property type="entry name" value="PH_Tiam1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043537">
        <property type="entry name" value="Tiam1/Tiam2/Sif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040655">
        <property type="entry name" value="TIAM1_CC-Ex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001:SF3">
        <property type="entry name" value="PROTEIN STILL LIFE, ISOFORM SIF TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46001">
        <property type="entry name" value="TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23014">
        <property type="entry name" value="PH_Tiam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18385">
        <property type="entry name" value="Tiam_CC_Ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WH1" evidence="6">
        <location>
            <begin position="105"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="836"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="1244"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="1585"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="795"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="891"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1543"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1998"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2084"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="458"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1545"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1562"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2011"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2054"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2093"/>
            <end position="2109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9521596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2109" mass="234271" checksum="5744DC5846CB9F07" modified="2023-02-22" version="1">MGNKISCANCNGKPSSAVAGHHHHHHPTSSSTGGGGGTSSSSATTIGITGSNVARSQQYAHHYHQVLSSSGGGGVAIVSGSGGGGGGGGGVGTASHHGAPMSNILNAGRSNHILRLWAEVFHVSASSGAVRWNQVSDDLVPVTVSFINGRYHITAFNSRVEKVLDCWLQSNKLGQASSCFIYWKDNVSGDTWGLNFTSPADARAFRECIQSGTVQLQTGSGPKRAESSYSLRAAATGTGGGNQDESSTHQSTQQQQQQQPHGRQSKAGSGAHLTTKYYSNRTAISTPNSPSKRRLQQQQVEQLQQQAYGQQQQQQPQCTCDCLTAEMLHKQRNGRIRYANFTRQDSGGTTQSSRSDGSLVRRQHERQQQYYRSAHQRSIDEHYRNRVSTTPSQQLSRTLGPAASSSHRHSRVQPMESNQQSQRIQMTGSGHQQADNYPTSIQNGGYIQIQHQKAIVHSSGKQIQQQQQDQQQGIQDQQQQQPSSRPQSQAQASQTQQLVSTATTTDDLVETTGTAPTNISQQQQQKRTSTRPKSLVSGTIGNSIDNNETRRDRTHRSLEGRRRSLERMQCVDLTDSSPTIPIRDNSNNRDLIDNDHRPSAAQLEEYERELRRRLLHGGDSTGGTGGTNNDALETFETLLKESMDDVANLMREVQHELTLIRAEEKRYQSQSTQSLHRIASAANLYGGPGSLHGAGVRSPIPQFDTMSIDGQLPFLPSFASSLAQASSAYHHHQLQQQQQQQYQSWDRLAAGYLTSSEISDDDRASLTTAISDDEDIIACSAAATGSDRYLINHHHTTHTHHQPSPKTQLNPRHQSRHHSQSSSSSTVAISFECLGSVRKSGFLSVKKWLIRKRHSLELARKRGWKGYWVCLKGTTLLFYSCDANMVNPTQNVEQQHQSTGQQQQPKSGQSSTSELTPKHLIFVDECLVQPVPEHPRRDNVFCLSTSFGDAYLFDATSLPERDQWIQVIHTACAAQIARNSGRCTISHYLVEQYQRIEQFVEQDYQQRQEAEILLTCCTDEKQKQQLINHVFMVEEKIERNRIEIFRLKSYFAALTNDEGPNPKTLLSQSSRRTKAQLNRIGVFTVSSLHAFNCAKNSQTSVEKSLHRQNSFGGSGGGGSISPVIPPSNDSAIVLHREMHYSPNHQRTTPVIIDGQPTTTTTTGNVTPLSRVQLTIILMTGEQRTMEVPQTWISEQLLSDIFGPGPESREYFLRCSETGTILYRNDLVANYSNHTLMITPKLLFTIDLVRESNEMLFGFSVESELYQNILRVFVMRVEPNSIAAMHGLCRHDEIMVINGALVQELDMMFVESILQEELTLCLMIRSARLDVPTQGQAILKVQPSNDIAGKTLQPVITQQQLLAHPGGGSGVGGGSSFDNEKTPSVTDDLIESLVCPPPPSTDFSQLILSDIQLSKYIVPKVDHFLPTSENLTSMNVIHQQQQQSSITDSTTGALLATADSYDHQGDDDRYISLANATAAITTTSPSQDNQHLQQLLQQTMISDEQIVSDIDCQQLLITDTGPPLSEAIQSALNQCHVDLTGEIGGQQQSQQQQQQLPLPPLPSISTSLSSASSQLSSNNASTSIKHMEKLIRELLDTEMNFCQSLKQLVELYLEPLSQNNFLTVTDIKVLFGSILKVIDAQNEFRSELTEVGEHILGDCELLLKKCQTFTTTSGGNNQQQEPTVNELGVGYIADCFAKHSKNFRDYSTFCASHARAVKLMAQEKTAVHEWLQKQSNGQISQSLESYLIRPIQRVLKYPLLLGQMKALCSKGTANYSKLEDAIKDLEKVAEHINEMQRIQEEYGAIFEHLARNHTRMATNTNGPAAINTLGQNGHIVDLSPPALKHYGNVDWINSMEFLGKNCRKGVEWSSICFVFSQCVVFLCKETIRQRKRMPTAKSIDVEIIRHQVLIPVIEVQVRACPQNDQSSNETDYKWELIQLKMNAGKRSEKIYRLSNKTSDERNEFLRVIRQIIREDVRRMNVTVNISLSSSSAAAAIGSTGKFRHNNDKQQSKNKSSDSATTTTSAKNRMSSSSKGMLMMKSNVQQQQKNDDQHQHHQHQHHQHHHHHHHKVPCGLCGKEIALGHHQRQPKEQLTTTTTTMRQDSSSTTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I480</accession>
    <name>A0A922I480_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding cassette sub- G member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ABCG5</name>
        <name evidence="9" type="ORF">DERF_007800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I480"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF113">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="40"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9517100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="646" mass="74631" checksum="5084C7E1346D55E0" modified="2023-02-22" version="1">MMNYDMRNTSPAETNETITMPHVLELVGVCHSGPITPNRLSLWNKWTNYPPSGLILKDVSFEVHSGEMMAILGSKGSGKKALLELISHRINQQSSTRGQILLNDVPLTLRVFQEQCGFISRRTELIEGLSVRQTLAYMAKMTIRQPIPRRLPDGSYMTIRFRVKQVMADTALSSLANYDVCELNEAERRRLIIAMHLIRDPLLLVLDNPTSDLSALDSYFIISMLSNHCHIFPFVDRVTFLCLGDIVYSGSTRMMMDYFSNIGFPCPELENPLMYYLCLSTVDRRSRERFIESSAQIAALVDKFKIDGHDYRKYNTPYSKMNALSIPLTAYGKASAWNVISTLIVRQFCSNLIMKRLFLKLGLIPLFCIFMYTFILPSLDETQNSFQTRSYIIFNLMAAITLMTPIITSYYFSQHRNRFYEDSSRLSIYRGPSLIVTNIIANIPLTMLNIFIAGSITYWTTPFRIDNYWMERWIIFCSVLWGVYTFVEQFTMAIMCFVKSPFKASLASCYFLTPWLIIGSTTLRSMLASPNIYYYINWLNIYYWAGWTLNFMEFQFNTDLVRVPHVSTNNTIELCSANIVPGKCMFLSGNHYLDQRFKDIKDIPEWSLIFWKNFAFIFIFAIGSYLINTVIYVIPLPASLKAKFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4C2</accession>
    <name>A0A922I4C2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4C2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7376" checksum="CA5FF8E69C93D59D" modified="2023-02-22" version="1">MSLKKEQHIYMCRVLPKLRPLAFAPLFVPYCKLITPSPARNCSSVKLRLFSSAGFGPKNGPGHSGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4U3</accession>
    <name>A0A922I4U3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="11">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PDHB1_1</name>
        <name evidence="14" type="ORF">DERF_004367</name>
        <name evidence="13" type="ORF">HUG17_0489</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="11"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4U3"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 11 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="12">
        <location>
            <begin position="62"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7644951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9520671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="390" mass="42946" checksum="21A0A3668AB8828C" modified="2023-02-22" version="1">MLGRIISSSSSLRLMTSNIKTTNIHPMFSSLSTTTSNNNNNNIHNGQQQRNFHQTSFHYAQLTVRDALNSALDEELERDETVFIMGEEVAQYDGAYKVTKGLWRKYGDKRVIDTPITEMGFAGMAVGAAFYGLRPICEFMTFNFAMQAIDHIINSAAKTYYMSAGRIAVPIVFRGPNGAAAGVAAQHSQCFAAWYSHCPGLKVLAPYTAEDAKGLLKTAIRDPDPVVFLENEILYGTSFDVNDDVLSKDFLLPIGKAKIERPGDRITVCSYSKGVETSLEAAKILSTMGIELEVINLRTIRPLDFETISKSIMKTNHLLTVEQGWPQSGVGAEICAQVIESPVFDYLDAPVIRVTGADVPMPYARSLEANALPQPDDIVMSVKRMLNIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5C7</accession>
    <name>A0A922I5C7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_006050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5C7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="197"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9522484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="540" mass="63740" checksum="CDD89D7622AC976C" modified="2023-02-22" version="1">MVQKRNNRYKAKSNVDKLSQQTTSPPSKQMNITNKISVFETTDFRIRPKSSLSIMVKNKIPHHHQLHYDELPPLPFKSYYTNSSWINKQFDSTNSLKNHQNPKSISMSKHYPYQYHHPNQNTNDTNLDILTNNRRPTSPFQSDLTSNLIHNSIMYYVNQIRPNTPQNRRRLYEKPTAPPEPVGGVVITPFEVLMHGYLLHRVVGRGSFSTLYEASRLFVSRGGVACKHVRIGRAEDIRPTDSDGQWRLQMQQNFIEEEIRILRQIRHPNIIQLYEIIIGDDNRDYYIMMKFAANKTIAHYLYQFYQKPLPETYAKRWTRQLMSAIQYIHEEHRVAHRDLKLENFLLDEKYVALLTDFGLAISLSIHSDPFSSSSSSSSSHQHHTGIANNHMLGNYCCTSANKSIDDRTKRIEILLSTQCGSTEYMAPEILNQELQSNIDTLPWCTYDPFRSDIYSMGVCLFEMLNYHRPFRWSSYKINNNRNGENNLVWQQRNRQYRFNKRIYLTEECRDLIDEMLEPRLAFRPTARQVLDHRWFKYSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5N1</accession>
    <name>A0A922I5N1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9523012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5N1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9523012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="168" mass="19016" checksum="D505B525E879FC15" modified="2023-02-22" version="1">MIKSSAELLAPSILLIFNKCLQSNYHDVKSYRPISLLSNFAKIFERLLNKNSLESIINTSLSRKSSYKTAIIAIEIASAFDKAWWPAILYELDKHDGSSDLIKLMTSYLTNRSANFNYGDFSIWKTLTNGCPQGGALSPLLWIILLNNLLVSYNIPNSKLLRLLMILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I679</accession>
    <name>A0A922I679_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">UBE2N</name>
        <name evidence="6" type="ORF">DERF_006425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I679"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031372">
        <property type="term" value="C:UBC13-MMS2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000015">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9522871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="153" mass="17204" checksum="78FEC10AB3D0D41A" modified="2023-02-22" version="1">MMTSLPRRIIKETQRLMAEPVPGISAVPDDNNARYFHVVVAGPEGSPFEGGVFKLELFLPEEYPMSAPKVRFMTKIYHPNIDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKVNEADAIKTAREWTQLYATNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I689</accession>
    <name>A0A922I689_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal ion binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RREB1</name>
        <name evidence="4" type="ORF">DERF_005845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001967">
        <property type="entry name" value="Ras-responsive element-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001788">
        <property type="entry name" value="ras-responsive element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000682">
        <property type="entry name" value="ras-responsive element-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052795">
        <property type="entry name" value="RREB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46451">
        <property type="entry name" value="RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46451:SF1">
        <property type="entry name" value="RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1270"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1298"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="821"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="958"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1449"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1541"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="975"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1121"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1210"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1452"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1476"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1564"/>
            <end position="1630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9522257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1653" mass="180640" checksum="C382B695F27D95D0" modified="2023-02-22" version="1">MATTALMQPAAAPTTSSPQSSSSSTIDAKQQQEQSSSIMITNGHHSSDSDSISDHETTNQQSEQMDTQLAGLKRKSFNETDNDDDEDDDDKEIEINDDQEIKRTTRPKLNHYHSSTEEEEETVDEKQPDETMKIMMMNSSQSSINVDNNNDGEDGDDDNDSIKPIVNSLSSLINMEMSIKQQSSSMNLTTKPKKLSTGKLERITERLAKRQHSNGGTATTSTISSISNGDSFIKRSASPTDESLLSNNDDKSELANENGESNDIDDDDDNDDDHMMKSSSIDDDMDEDMNEEDEDGMENGLQALGLMGNVAYMNDDSFKCPVCGLKLDSQHTFTLHIRSHNPNDHSNTCSLCGKTLSSASSLDRHMLIHSGERPFKCSLCGMAFTTNGNMHRHMRTHGHGSIGYTPRGQKRRAKLLTQALEKAVAAAAAGEEVDYGAINKLKKSILESKVTVPTTTGGKRQSKNQQQQSAATTFSEQLLSSLAPNVSIEAAAAAAVAAAHNAAGSENGDSILSHLSAAAAAAANSQHQSGSGRKHRHRNSHSTMTTSHHQAAITPTTSKSNDKTVAKESTSTTTTSTSNLPLNLANNSIVSWPTNQHSTMNPTSTPPTTIPEKGRPGRKKKQRLSDPVSMNRMMNHHAHHPSSLPLSLQPSSTPATQVQIPQQPSTPTIAPPPTLPPTNHLSPFGPLKDRCPICAHPIRTMPELHLHMMAYHMQERLFCNDCGMILDNYDTYTHHRCTASAATVMSALRQNPNLQSDLLFCSSNTSRMNFSSARTYAANLELLRAGLTAAAVTNGGGGQQHLQAAAAAQVMLQAAQLAQQQQNSSQQQQQQQQQPPQPSQSRKSNNLQQATVNCSQCTRKFFTSKELKHHHDTYCHQCQLDCDSISTYQLHQFSHSFEKLSQSQLHSSHADKMQLLKNAAISAFPFQLSSPTASSPSLVTNPSSSSSSSLISSASALSHHDHHSLIQPPPPPTLPSSSSISLTKATSIPTIPQHSTSSSIASLTSMANMKPDLADIESILSIVHATNAMKNANHSSSSSTSTTTAATNNSINNNDNNNKQSMNGTQLRSPISPNRASDAGDYRGATQMKRHSQMNGGEATNQPDSPASADSAAGAVAASNLPGSCQTTTMNMTVEHQHHNHHHRHSTKTDLNTNTNGTSTATAMALCLTKSNNNATKNIAHNDKIISPKSKESSSKSSMVKSIKSESQQKHSSQMNDSKTGNVPTTINQSGNNQIKPPRFRCESCRLSFKSLNALRRHNRGHTAEGGHSHACHLCPYKSLDKSTLIRHLRTHNGERPFQCAICKYAFTTKANCERHIRKRHRNLKSKSEIRNAMQYNIDMASTAAATRLVSEKIFIERDQLPTSQDTVCKKCDEDFGTNRELRAHLRQPNNPCSQQLKPFVCTICNIGFNTRNNCVRHIIKQHPTTVEIGHDDDEGTTKIMDAEALMIETGSSSSLSPSPRRQSTKLSSKRNDNNHHHRHNRHRSSFSSTLSSGESSECESFAAIHSFDNGGHNGSSNGKRQNGKNLKNLAAATFCTVVDENNDNKQKQQPPSPLNLSKKSSSEDDFPIPIEEEDDDDIYDDEYEDDDVGEFDDDIDCIDDDEEDDIDEDDDDDDEGVPIEDDDFDEDEISANNNHHHHQIGPTVLDLSFKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7D3</accession>
    <name>A0A922I7D3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_000452</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7D3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000005">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF565">
        <property type="entry name" value="MOCA-CYP, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9526354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="515" mass="60198" checksum="0EAC1429C67C4B12" modified="2023-02-22" version="1">MVKLKQLRPRCFFDISIDGKNAGRVIFELFNEKCPKTCENFKALCTGEKGIGQLTGKPLHYKNVSFHRIINNFMIQSGDFSQNNGKGGESIFGGTFKDESFDFKHERPFLLSMANRGPNTNGSQFFITLVPTPHLDGVHVVFGHVIAGQDVVMKIAQQSVDKQSRPIVPVCISNCGELVPQIKPKEKTLSVDKQSHKKRRKHSDESDTSGDSDKKDKKQTTNPVEKNPDNTEIEQNENSISLFNPKYSVRIDPEEIPEIPQNRFLHRGIRQSPSILDDAITNKEKEDSNKNRSQSSNYRNDRSYGRRIIYTSSGRKIKGRGSIRYRTPSPDDNGRYSRKSSRQWRRSETPPYWRAEQAKLRPWKQIMSAKNNSKEQRHSNDNSRRRSSRSRSYERRDRRHHHYHHHENRNDDDNNRSHRKHRSSDHHHHHHRSRSSSPAKYRDRKIDENSIQKRKFREFPSPRSSYSPEKRNSISKHKPSRKSSKEKENRHDPQSESNNNNTHRRIIDDNKRKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7P7</accession>
    <name>A0A922I7P7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_006396</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7P7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015375">
        <property type="term" value="F:glycine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF313">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="767"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="126"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="8">
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            <position position="195"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        <location>
            <position position="494"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="559"/>
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        <ligand>
            <name>Na(+)</name>
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            <position position="562"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        <location>
            <position position="563"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00006459"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9522838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="796" mass="90943" checksum="21A5FD1AD015E9D6" modified="2023-02-22" version="1">MDNPTIVIDDNNNNNGHHVIGDDNDNHHHNNNQTIDLNIDHIDIDDDEDDNVDDNDDDDDDDDERKAETIQLRPYYDWRFDPQKSVQQNDNTLMMMMGTEFPRVSSQVPLSPKDGYDISFGYDLEIENDEEDDPDDDDDEDDDDERTMKHRQAPYPPAKRVPKKKKSSSLKDRGTWQGRFDFILSLIGYSVGLGNVWRFPYLVYSNGGGAFLIPFIVMMLLVGFPLMFMELAFGQYASLSPVVIYKHFSPLFAGLGYGMIAVSGVVMLYYNMIIAWTLYYMYASLKPELPWSRCDPLWSTDLCYSYKEKDDCIANDPNAIYYNRTCFNHTDVQRLNLTTNLVVSQISPILEKKAPADEYFNNYVLGNIETIDETGNIQFHLLISLLIAWIMVFLCLSKGVQSSGKVVYFTALFPYLVLVILFIRGITLPGAMQGIAFYVKPDFSHLFAAHVWGDAAVQVFFALSPAWGGLITLASYNKFTNNCYRDSILVLFANAGTSIFSGFVVFSIIGYLAHEMDVAVDEVVDQGVGLAFIVYPEVVARLPISPFWSFLFFFMLITLGLDSQFALLETVQTAVLDRFPALRDHKMVILLLVSTLGYAGGIIFTTQSGVLWLGLFDHYAANFSVLIIAITECLLIAWYYGTERFLRDIEKMIGQRSLRWKRLWSIMWKYITPSILMFLLIFNWIKHEPPKSGDYIYPEWSNIFGWILAFIPTIIIIATMLHTYFTYDGGKNKSIAQKINTLMQPSENWGPTHKNIEKLQRRKSSRLAMMAHGTITITTTTTTTIIIYIGNDEWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8G7</accession>
    <name>A0A922I8G7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin synthase catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MOCS2_2</name>
        <name evidence="1" type="ORF">DERF_006216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8G7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="162" mass="18400" checksum="E37FB56FB12CB67A" modified="2023-02-22" version="1">MNQKISVELSNDNLSVDEATKFVSSPNCGAISIFIGTTRINENDSSKDNCHVVKSLYYEAYDQMALAMMREIVSDIISKQNDDDQSYTKVYVHHKLGHVALGETSIIIAVSSPHRTTSHRMVMEILNKIKQNVPIWKKIQFQDTNTDDGQWSDKSEAFWLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9K8</accession>
    <name>A0A922I9K8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C-terminal-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CTBP1_1</name>
        <name evidence="9" type="ORF">DERF_000953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9K8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000012">
        <property type="entry name" value="C-terminal-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051638">
        <property type="entry name" value="CTBP_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46029:SF7">
        <property type="entry name" value="C-TERMINAL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="39"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="135"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9526895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="437" mass="47739" checksum="F59360707A633747" modified="2023-02-22" version="1">MDKKKTLKRARIDCIRGPNISNGPLHSRPLVALLDGRDCSVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMWHTINLTKEDLEKFKALRIIVRIGSGIDNVDIKAAGELGIAVCNVPGFGVEEVADSTMCLILNLYRRTYWLANMVRDGKKFQGPEQVREAASGCARIRGDTLGIVGLGRVGTAVALRAKAFGFNVIFYDPYLPDGIDKSLGLNRVYTLQDLLFQSDCVSLHCSLNEHNHHLINEFTIKQMRPVVVLYYNYQPICLGAFLCNTARGGLVDENALAAALKDGRIRAAALDVHENEPYANHGPLKDAPNLICTPHAAWYSDASSTELREMAASEIRRAIVGRIPDNLRNCVNKEYFTGGAYGDGMNGASSYNYTGPIVPHSTTVEPMPNASLSNSLTPSHSTPHSTLQDTNNHIAAKAESSEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9M5</accession>
    <name>A0A922I9M5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9M5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="9883" checksum="299B52E688680B14" modified="2023-02-22" version="1">MKIFKKKRRKSSKHDYDHDDDDDENSPELNRIQMFQVSIFRIKNLPTKWMFITTITTIIIMIEAKYSPSSSTADKEMKIEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9T1</accession>
    <name>A0A922I9T1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9T1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="9973" checksum="F1A9EC6CF7106214" modified="2023-02-22" version="1">MNVPSFIIDVFTRPPKEGTETILYIALSPKLTNISGKYFEDCKEQKSSKISYDENLQQQLWLRTWQDLRPWLNNNEYNRLIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAM4</accession>
    <name>A0A922IAM4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAM4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="359"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1133" mass="130475" checksum="0467FA1D4E45CBE9" modified="2023-02-22" version="1">MMVIQPDTTDTNIVNHNPLSSSTSISSNNNNNIEQRTTTRNHETRSSSLILTDSYAMAFSTKITTRNIPTQQQQQLQQQSMMFQQQQHNNQLNNHQQQQQQQPQQQQQQRYIDYMIGIIFVQETLITSDDSRRFPNEICLGTILLSKYNDCTYVDSLRKIIQQESIFKMDDDYAFLTPFGCTITVEQESQTLTYHLITEKNTIRFRRKYCPDRFSLIGYYSTNRSSIFIDYIYGTYYLDLKTIRKIIDDKLKDMKPVNDMKLSNTNYYFRQNSGCIINPINESNIFLIEIVNCLNIMIEFEKQIDMETRYYAVNQDRPIKKYIEDTVSTNMVDGRTDSVLIKNRPSRSLFRRKTSKRRKGPQIMISYVRHEAADHAIQLKKTLLECGFSVYLDVHEIQMGSDWQDSLNSAVQNCNYFVPLITQNYGRTQWTNREIKLADVKQKHIIPINFLDLWPPECLAIQFATTQYISWNPQSDANDPNNRYDGKTWPSEAIYGVTKLIKERIYKLSQRIQSTAIDDITINNTDNNRQQTNRKLIVISAHPEQQQASARIKSILSDKYDVWCSNDFKDFDVGTKTVNKDNNTSSSLSSSSPYRNRFDQDLTTISEENSTITRPTQDYARHIAENCKQRPKSVPNNDRLEINKKKELSRVFSYGETTHHSSFSPDKLDHLQCFQRKVSQSSLIIILSSEQYFKSKTSEEHVYYCGQRLATIHVQYDDSPSPVWFTKLTSHDHPLKYKSSTFDDDLLNRVSRTLDPDCKEIKYYDHMIKCLADMMKKNMPDQETCVFVFGSTNTDNLDPRTNQICQEIGKELAKIVKNINIITNGTYGAGDIVAHTFYQERCTNQQTTQKSIGSVFHIVPERQDDLDVTPKKVSYGQTIFLGQSTKERDSVIARMLDTALLIGGDKDAAREIEEFIWNDHFVIPIKSTGGAAGGEFEVPQKMFTCPIGVDENRWAVLSQTDATPRDVAKAVVDIIFQLKKAIYEHASSRQKVDNALIQKSSSDRQVKIRLANRKKLNTGSMNSNGSKTDNREMNNPIMVFRNNNHDHLNNINHQFFHFDVSSTQSSMEQQRSLPIWPRSNSSSEDSSNSSNSDSGDNGTTGGSSIGGGHIGDNKMNGIQKFLQQIRKHFTRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAQ8</accession>
    <name>A0A922IAQ8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ATG5</name>
        <name evidence="15" type="ORF">DERF_000059</name>
        <name evidence="14" type="ORF">HUG17_7948</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in autophagic vesicle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Preautophagosomal structure membrane</location>
            <topology evidence="2 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ATG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAQ8"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.190:FF:000001">
        <property type="entry name" value="Autophagy related 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000100">
        <property type="entry name" value="Autophagy related 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048318">
        <property type="entry name" value="ATG5_UblB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04106">
        <property type="entry name" value="ATG5_UblB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="13">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="12">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 UblB" evidence="11">
        <location>
            <begin position="187"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7640481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9525929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="279" mass="32988" checksum="DBFF86F79C33B7A2" modified="2023-02-22" version="1">MAEDGEILRYLWDSTLPVAFHLSDQDRHSIKIPEPYYSLVPRLSYFSLIIDKIAVYFSQFIDINNKTSANLWLEYLDIPLKFNYPIGLLYDLYEPDIQLPWNITVNFDRFPEDTIVRCNNRSSMESAFLSSLKEADALKRREPIVSTMPKKDHNQLWMAVVNHKFDQFWSINRRLMAPTTNQQTFRYIPFRFYIRSPTFSDQPLLVQKLIKPILDSGDQATYRDLIIQVLGDEYLNNDKYNLIVHGIQPEMDTPLQWMSEHLSYLDNFLHIVIHDKSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAS1</accession>
    <name>A0A922IAS1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_002037</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000112">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000126">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000150">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000159">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000929">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
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            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1058"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="1087"/>
            <end position="1114"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="274"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="406"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="483"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="594"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="848"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="898"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="942"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1106"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1255"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="1260"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1272"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1302"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1321"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1341"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1351"/>
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        </location>
    </feature>
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            <begin position="1391"/>
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        </location>
    </feature>
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            <begin position="1412"/>
            <end position="1429"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
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            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAH9528064.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB82</accession>
    <name>A0A922IB82_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Barrier-to-autointegration factor-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Barrier-to-autointegration factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BANF1</name>
        <name evidence="6" type="ORF">DERF_002283</name>
        <name evidence="5" type="ORF">HUG17_10247</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB82"/>
    <dbReference type="OrthoDB" id="9997163at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.40:FF:000002">
        <property type="entry name" value="Barrier to autointegration factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.40">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051387">
        <property type="entry name" value="BAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004122">
        <property type="entry name" value="BAF_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036617">
        <property type="entry name" value="BAF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507">
        <property type="entry name" value="BARRIER TO AUTOINTEGRATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47507:SF6">
        <property type="entry name" value="BARRIER-TO-AUTOINTEGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02961">
        <property type="entry name" value="SAM_BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01023">
        <property type="entry name" value="BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47798">
        <property type="entry name" value="Barrier-to-autointegration factor, BAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00079764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7636277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9528331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="89" mass="10219" checksum="3C76989986B733BF" modified="2023-02-22" version="1">MTTSQKHQNFISEPMGDKPVTDLAGIGEVLGKRLSNKGYDKAYVVLGQYLVLKKNEELFVEWLKDEANANTKQARDCYQCITEWCEQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBQ3</accession>
    <name>A0A922IBQ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBQ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="41" mass="4434" checksum="DA532914899711F3" modified="2023-02-22" version="1">MEVGIVQQHVVMVDINSSDEEKILECGSAPAIRIVSYSNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBY0</accession>
    <name>A0A922IBY0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_001975</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBY0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15045">
        <property type="entry name" value="7tmC_mGluRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06362">
        <property type="entry name" value="PBP1_mGluR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000145">
        <property type="entry name" value="Glutamate receptor, metabotropic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000001">
        <property type="entry name" value="metabotropic glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00980">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="836"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="647"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1152"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1217"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1156"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1223"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1241"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9527998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1250" mass="141684" checksum="32FF117A4A511FC3" modified="2023-02-22" version="1">MGNCYDNTMMIELKQTTRLLLQSINDDLSKQQKQTNRMAEYPGDIMLGAVFPIHQHDTTNYSCGILQTEGIQQLEAMIYVLDRINNDPNILPGIRLGALAVDSCDSPHHALEQTIDFIKSFVARSNRRLIRPEFHCQDQTAALYKNGELDRIVGIIGGQSSEVSLQLANLLRLFHIPQVSYMSTSSTLSDERLYQYFLRTVPSDTNQVDAIIDILRQVYCSFSILLFLIKFNWTYVSVVYSDTEYGNNGYDLLTTAAARYNICLSSPQAINVERFRQIDYDNLITTLMHKINARVVIVYTDSHVARKIMKAAKRRLNKNGGRLDRFIWIASDAWCCRDFVVHGLEPVVEGTISVTPLHYPLNGFADYFRSLRPDYPPERDQLNPWFREFWERHFRCKLMIDESSDNINGDGGTTTSSTDSESESKESPEMVFCNQSLKLDVTKHQHHQHLQQSPSLHFVRDAFYSFAMTLNQIHQKVCNGTAGLCDEMKELIISGEYIIEQLRKVQFRDEGGRLFRFQKNGDAPPRYTIVNFQRLSNGTYQWRPVGNYMISENDNRARLKLEMELLQFKHDMNRFPESFCSEPCSKGQAKLQLEGDTCCWLCTNCSQYQYLLDEFHCEECPLGTLPDVNKTKCHLVPTIYLSWTEWWTISSIIFAIAGMLATIGTWIVFFYYAETPIMKASGRELSNLHLAGIFLSFAVTFVILAKPTPLTCGLTRFFLGFCYTICYAAIVTKTNRISRIFTHRSCQRPKFTSPQSQLVITSLLISVQILINIFWFFHTPPDTKLVYSNREIALLICSGSDHLNYLISLIYPFILIGFCTVYAFKTRKCPEGFNEARYITFTNYTTCVVWFAFLPLYVMLSITTPLRAITLSSLLSVSGAVQLCCLFVPKMYIALLKPEKNTRETVMCGGHRSLVFNMPVAHHHRRYHHHHYHHHNHHHRSNSHEMHKQWHHSTRPSAASTDGQIITAMVTETNDNDKNNNYVGSNINNNVANGNSIKNPSTISNTSMMMMMMANDETSATIVKNGDCNSSGNCNDKQIIMIEPYSTSSDIDTTTTALTATSLKSMNITFSNNNNNQTLKLNNSRLKSGSIVSMPDKLSIPEEEQNDCNDGNIENSVISKNPIFISDEQQHFNQRSQSACAAVIANGQTKDNEFHSSLSSSPSSTSSSSSNNRSNSSSMSLIFSPPPTQSSPLNNGLIKIKKHNTKAVLKNGHQCWPSIKLDGNSSSPTSTINDSAHHSHTQTTIADDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDA7</accession>
    <name>A0A922IDA7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CNOT8</name>
        <name evidence="20" type="ORF">DERF_000639</name>
        <name evidence="19" type="ORF">HUG17_8401</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">JKM2019</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDA7"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000005">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="342"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="358"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH7640932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH9526563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="457" mass="49753" checksum="E073924387FF7E15" modified="2023-02-22" version="1">MPSAYGHTNGHHMVNTNSMALTNGQTPTSAIAASTSSPAHRHAAGIGSMNAGNHGGGSVGHPSNQTQTHGPPQTPQTNEEVGIREVWAHNLEEEFIRICKIVQHYPFVAMDTEFPGVVAKPIGQFTSNSEYMYQIMRSNITLLKIIQIGLTFMNADGKKPDGHCTWQFNFRFNLNEDMYAHESIELLTNSGIQFNKHDQDGIDPTEFAVLMFGSGLILTDQISWLSFHSGYDFGYLLKMLTDKQLPKKESEFFDLLKTYFPRIYDLKYLMKSTKDLKGGLQEVAEALTLVRKGPQHQAGSDSLLTGETFFKLKEMYFENDIEEKRYSGFLYGLETAETGKIETDDDLTASNPTATNNTGNRNTPITSTTTISSSLSVTNSTTTNGGSIIVSSSGNNNTSNGSNNSGSNNDSAVVSGGKIEDVNISDANNSENSIITSSSTSNSTTINPQQTPTSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDT3</accession>
    <name>A0A922IDT3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDT3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9530242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="6967" checksum="BFBD6F8E3096B861" modified="2023-02-22" version="1">MDSIHLELGLFDKTWTIIIGGEFKRFDENKRLKKGQILSTTTLTTAKGVNVIIKLTTTLSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEE0</accession>
    <name>A0A922IEE0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PRMT8</name>
        <name evidence="9" type="ORF">DERF_003252</name>
        <name evidence="8" type="ORF">HUG17_5254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEE0"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF124">
        <property type="entry name" value="ARGININE METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="189"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7642209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9529363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="366" mass="42156" checksum="F63BDC5330EBF163" modified="2023-02-22" version="1">MDIDIKNIAVNGESQEKMACSNCGCSELVPVNDTIKADDMTSKDYYFDSYGHYGIHEEMLKDEVRTKAYKNAVMMNRHLFKNKVVLDVGCGTAILCMFAIKAGAKHAIGIECSSIIDVARKIVADNNMSDKITLIKGKAEEIELPAEYPKVDIIISEWMGYCLFYELMLSTVIYARDKWLAPNGMIFPDKARLYITAIEDHQYKDEKINWWDNVYGFNMSAVRDLVISEPLVDLVEPNQIVTNYYKVKEVDLYTVTIDDLTFESNFSLIAKRSDHVHALVTFFSIEFSKSLKTIGFSTSPEHRTTHWKQTIFYIDDYMTIANGEEIVGTFYMAPNLKNRRDMDIKIHVDHRGELEQYNNSFLYKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEV3</accession>
    <name>A0A922IEV3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEV3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="96" mass="11140" checksum="F777D86D06F713B7" modified="2023-02-22" version="1">MISSKRKPLITIKQQMVAKDEKNEQQQEVATPSKSMVKTIKLNNNELPTSNIPRKDGTKSLTKFKTTTENYYEKMYSKTPACKKRAKIRMQCQIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFY4</accession>
    <name>A0A922IFY4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Intraflagellar transport protein 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">IFT43</name>
        <name evidence="1" type="ORF">DERF_003424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFY4"/>
    <dbReference type="OrthoDB" id="206950at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029302">
        <property type="entry name" value="IFT43"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15305">
        <property type="entry name" value="IFT43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="154" mass="18118" checksum="17D222D221829645" modified="2023-02-22" version="1">MYSWQKNGQYDYDEYKLNDEFQVDSNQSIRSLYVDDDDDEYYPNIPDVEDLHNQEFMKQTAMAPASLSYPKLNTIELTRAKSPKNQQQTILSSKEDKELSTLLDCLLPRDHVEEDDATWSWDSLMTEIMNKMKHSSKFKVSERVEISNNDSDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KT22</accession>
    <name>A0A922KT22_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KT22"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="202" mass="23390" checksum="D932DA20F8B4DE94" modified="2023-02-22" version="1">MSSVSYNPFIYCWLNKNFRKTAMKILCCGATECCCGLILLLKRRRQQQQQQNDESILMMVKNNHNHHNNNASNSVENNNNNNNKNNLTTAITIITDDDDQQQQQQQHPNRSSMTLITNTMTNTTLNIAATTNTSTTLYDNNNNNDNDDNDNTYNCANCLWWNQHRKNRSGAELNVNHSVFSKKCPQYKLAIERYHNLIDYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVT7</accession>
    <name>A0A922KVT7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVT7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037939160" evidence="1">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="7289" checksum="7812E7E88B6A0F19" modified="2023-02-22" version="1">MFRFIVIITSSLVLLLQRHRMCGDWYFSSSSSSSYHISIDVRKKKNDLYYYHHLHDIHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KXF9</accession>
    <name>A0A922KXF9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RCC1 and BTB domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RCBTB2_10</name>
        <name evidence="2" type="ORF">DERF_011863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9500987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KXF9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF14">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9500987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="300" mass="34561" checksum="557D3CCA1F0E8317" modified="2023-02-22" version="1" fragment="single">LSDKEISSTPCLIAFQNDDLINIRIKEIVAGDRHSLFLFENGQLWGCGYNYNGELGLGNRRSKLAKIPIGNLQQIKCSKIHNFSLAYDGSSYYAWGKTKYVKWLLPKKLDGHPTSFASASVQVLNSPITFGLTSTIYEFGSHDSISYKSIIELFDNQDNYDVKFIIDKKDIKACKCYLKSVSKFYGDKFSDDWKEKKEVTISGYSYETYYAYLRLLHTGKIQINQQNITELVDLANCYGDESLMEYCATFIRNDLDEQTMPKYLPLINKYEMIELYEKLAHLYKNQNQQSSSSSKRTKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYW8</accession>
    <name>A0A922KYW8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ACO2</name>
        <name evidence="18" type="ORF">DERF_012780</name>
        <name evidence="17" type="ORF">HUG17_8648</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="13"/>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYW8"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01578">
        <property type="entry name" value="AcnA_Mitochon_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="66"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="582"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="517"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7637544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9501977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="779" mass="85424" checksum="5E6748B964B4ACFF" modified="2023-02-22" version="1">MLYRTSLTKPYLGVWRWSLNSKNSRCFASAAVPMSRFDNEPMPYTKLSENLKIVRDRLQRPLTLSEKILYSHLDNAREQDIERGTSYLRLRPDRVAMQDATAQMALLQFISSGLARVAVPSTVHCDHLIEAQIGGAEDLKRAIKINEEVYNFLSTASAKYGVGFWKPGSGIIHQIILENYAFPGVLLIGTDSHTVNGGGLGGLCIGVGGADAVDVMANIPWELKCPQVIGIKLTGKLNGWTSSKDVILKVADILTVKGGTGSIVEYFGPGVDSISCTGMGTICNMGAEIGATTSVFPYNSRMRDYLVSTNRKPIADLADQNRGLLSADPECKYDRIIEIDLDTLEPHVNGPFTPDLAHPISKLGENAKKNGYPLEVKVGLIGSCTNSSYEDMNRSVSLAKQALNHGLKSKSIFTVTPGSEQIRATIERDGQAKVLREFGGIVLANACGPCIGQWDRKDIKKGEKNTIVSSYNRNFTGRNDANPATHAFVTSPELVTALSIAGRLDFNPLTDELTGADGKKFKLEPPTGDELPKDGFDPGHDTYQAPPKAGSETQVQVDPKSDRLQLLSPFDKWDGKDLEDMVILIKIKGKCTTDHISMAGPWLKYRGHLDNISNNMFIGAINSENNEANKVRNLVNGEWGPVPDTARFYKSKNMKWVAIGEENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFANPADYDKIQPDSRISLVDLKNLAPGTPVKCIIKQKDGKTETITLNHTMNDLQIEWFKAGSALNRMAELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0S1</accession>
    <name>A0A922L0S1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Voltage-dependent T-type calcium channel subunit alpha-1G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CACNA1G</name>
        <name evidence="20" type="ORF">DERF_012915</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008332">
        <property type="term" value="F:low voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005248">
        <property type="term" value="F:voltage-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070509">
        <property type="term" value="P:calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086010">
        <property type="term" value="P:membrane depolarization during action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000018">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000120">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000125">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000007">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000008">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000009">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000012">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF230">
        <property type="entry name" value="CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 16" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8 16" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="889"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="966"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1581"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1613"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1655"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1719"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1819"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1899"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1929"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1962"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2025"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2121"/>
            <end position="2143"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="19">
        <location>
            <begin position="10"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="19">
        <location>
            <begin position="766"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="19">
        <location>
            <begin position="1579"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="19">
        <location>
            <begin position="1898"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="436"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="544"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="613"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="682"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1169"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1231"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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            <end position="1461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2220"/>
            <end position="2262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2521"/>
            <end position="2566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
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            <end position="704"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1178"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="2236"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
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            <end position="2539"/>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
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        <location>
            <position position="949"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
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        <location>
            <position position="1791"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH9502126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2566" mass="291874" checksum="00E8040B8CA19914" modified="2023-02-22" version="1">MNFPFSTNNTWFERISMMAILLNCVTLGMYQPCADDETCTTSRCKILQTFDDIIFGFFALEMVIKMLAMGIMNAPNSYLSDTWNRLDFFIVVAGALEYCLDVGNMNLSAIRTVRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRQRCFLSLPPNTSIPDSSISAFYQDEDGDKDYICSMEKDNGVHRCNNLPKSRYYHLLCSENALPMPETNEPNDSSCVDWNQYYTDCRPGDHNPFQDAVSFDNVGMAWIAIFLVISLEGWSDIMYYVQDAHSFWSWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARCQSLNSLASFSLNEQLNCYGAIIQYLSYLARKIWRNTSRWYLKRYGRKKHRFKSNQHPHSHHYHMNINQTVCCHCNSGAIITKNLSPQLSIRQPQPQPQQQQQQQQQQQQHSVNKQIDVDHESSDHGVVIVSSGGRKKSSTTSTSNTNGSQIQMSNVPNTNVNPLMIGNSDIVVVDCQSIINDNNLVESSNAAANDLVVITPPPETTKTKKSKIKNKNRSKNGGKMRKRSTSSSASKQSTTSPTTKSSSSAILNDNDVDMMMIIHRDDGDDNDSTAMIKRDHRRGSVPNLYQHGNGHRNQTNHHRYHHMASQLSSSHATSEFHDARRRSPCKCQHYQHSHHHHHSHQHQHHYHHRNRNKKEMDRSSCSSVLSTNRNRYARRASSMISVGSCRRCCPKACTRPLCQTWKRIRRILQNIVKHNYFQQAIFLAILLNTFSMGIEYHNQPESLSHAVEISNIIFTIVFCIEMVLKLLADGFYEYIKSGFNVFDGCIVILSLLELLEEHGSGLSVLRTFRLLRILKLVRFMPALRRQLVIMLRTIDNVAVFFALLMLFIFIFSILGMNLFGCKFCDRNPIDQTLECDRKNFDSLLWALVTVFQILTQEDWNVVLFNGMERASPYAALYFVALMTFGNYVLFNLLVAILVEGFSQEDELKRSISSSNDKVEQIKQERLIYFYSHNDDLEREIQTLENPPNRIDDLLVYHAKKSLSNQGSSIGMNRNPSTSVTAANNDLINTNDEKMLPEISIGTIATSSSTNVGNKNVVRISHDHDTAAAMPTPTGLIPPPLITRTAATPQGSPPTSISDGFFPPFPSSIPTMIKSPTTPIDMMVVDPSSSSSSSSSPSSLLIDDQQQQQQQHHQSMLIVSYKDGESHSPTTSVLPTQSMLSPSHSIGFQPPPPPPSVDISSSVSCDGRMRSGSVKNVLGFGNLQIIRSKSHDGNNEESMKRPKTIRQLSTTVYSSSAHQHGFPLRKELSCNQIKNLGLDSEQSTMIVKPVTKRPVTAKQRRKSFFQFRQRSSQGSMTNDQKNIASSTSIVGEDSFCPIYAKKNIVLRRKSLAADLLLRSKSVAHDDYYYGDYGDPGDNDEKSSKQQQSMRSDSHHHPSISISSNMSTDGDHRKNSLIHEVRVLSPRNSLKGVFYSSSVISIRNSNSNELYGFVVNQPSSSITAAATAIETETAQATSTTKASELNEKIQKFCIYFKWTSWMTVREEYSLFIFSPTNRFRRYCVWLADHPYFDYIVLIFISMNCITLAMERPKIPPHSKEREFLTIANFVFTLVFGIEMLIKVIAKGLFYGQNAYFHNGWNIMDGSLVGISLFDIFLSFFAQRSPRIFGILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGSFYYCDGPKAKHVRNKTECLSDPRNTWINRKYNFDNLGQALMSLFVLSSKDGWVNIMYTGLDAVGVDQQPIENYNEWRLLYFISFLLLVAFFVLNMFVGVVVENFHRCRQEQEQEEKAFRAMKRAQKMEKRRKKMREPPYFIGYGRFRLNIHRIVTGKYFDLVIALVIGLNVITMSLEHYMMPMELVYALKLFNFIFTTVFIVEAIMKAVALGLRRYLKDKWNQLDVIIVSLSIMGIILEEMESTLIPINPTIIRVMRVARIARVLKLLKMAKGIRQLLDTVMQALPQVGNLGLLFFLLFFIFAALGTELFGRLECDEEHPCQGLGEHAHFQNFGMAFLTLFRVATGDNWNGIMKDTLRDKCDSSSDCLRNCCISPVIAPLYFVVFVLMAQFVLVNVVVAVLMKHLEESHHQMDEDEDFEIDQEIAREIEAERRALAEAIERRQREKNLKVRRPLLKMASLPSNFTFTFAGPVTPLTPPYVINTEQNKQNPNSKNRSLRKKKKPFHHHHHNSSISLNDEPPKSATILNSGGNYFNFPCQQSTDKLTKLNGILKKSHSLRVAKTAADRYRIQTNSNHNCGEQKALLVKMAKFDHDDENGVGNCDRYWPSSRSMTDNFNYHYCSLNKSSNAIDEPSRSLQLSNDNDDFQSSRIIDLTDHHHHHHDHEQSSIMQSPPVMIKIDDYYRASNDDDKNQTNRIKCNENSIHQKSEIVIDHASGSGGGGLHHLGGDLLTTTVATTTIASPSRNVSTKYRKLSDFLDEESGPLSPALFGTYPELFNSDAANTYNDYNEDDDLNEDDDQQPKRNNEENTSLASIESWPSGDPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0T3</accession>
    <name>A0A922L0T3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_011742</name>
        <name evidence="2" type="ORF">HUG17_9982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0T3"/>
    <dbReference type="OrthoDB" id="6505866at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038277003" evidence="1">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7643291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9507038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="122" mass="14044" checksum="09F606CCF64CA920" modified="2023-02-22" version="1">MKNFPPILLLLTLSSSLLIGNHFMANGQLIIDENDPSGQRIIHLLMDTINDYQHKHSDNNHDYKLKRLVYTFGESPKYSVELIVIDDQTKQTLMCTVELFEHESSDHKTMSYTTGAVKCHHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0Y9</accession>
    <name>A0A922L0Y9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Argonaute 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AGO1_5</name>
        <name evidence="4" type="ORF">DERF_013829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0Y9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="508"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9497882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="840" mass="97565" checksum="88BE504971B570A6" modified="2023-02-22" version="1">MSQNRGKPKRGGFASGGGGGGDRFAGNNNNRYPRNNDNRQRSFDASPVEFPESQQYPIRRSLSPKVDQKNSLNLVGNYYKLDITEKEIYHYNVQISQPPSINQTQKNDSRSEQNREKFLRNNSREILKEFLSKNPTLFQDIPFIYNGWENLYTTKKIQLDNDYVNEFEYRVGNGKPDRSVPKTNVEIVFKEKINLKIIEDFYNGKVNEIPNQIIDILNKLFAKILMEYYTVHGQCYFDMNQLRSVRELSFIEFVYGFELSTRMAQVGICLVIQPRVECLISSKCKTLMDLINEYDYKSGENITNFEKINFKKINSFIKNLSIYTEHEVKINPQLPMVQMTKPHVYMPLDLCYIDEKQFVDNTKNYPNIHKVFMKECALKPESFFNKIQSYVDRIGKIGSTILEEFGVTLQNKLVKFNGYQLDKPRMVVRNPRAITKSASIVPWAFISFDENISSGVINDFIDGLVDEAEKMNSNLQMGLRYKDFKRIKNLNDIENVLKKLKTECKIEFCFVVVPEHHNYLTPSDIYNAASSIGCKDLGLKIQCLNGFRVANVPGGYFNNLLFEVNGNLGGQNTVVEPRYFQQQIGTKIQLNETMIIGIDVNHPGFFECSQNFRVSIAAAVGTTNVEMTDFVNCFRIQKRERTMEIIEQLAEMIKELLEKYKKINGKYPKNLIIFRDGVSESQFDQVKTIELQAIRRLIEQTKLKIRFTLIIVQKRHHTRFVKTMPTSSDANQKVHQHEMYLVGTSKPTKYIVIENQLQFTNSELHKLAYLVCYNSVRFSSPLSIPTPIKYADLCAYKCKIHLLHELKKNPIQSTDEWNVEHLQQMITFHDPKAQDSFFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L158</accession>
    <name>A0A922L158_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L158"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7548" checksum="89855E71569F63DB" modified="2023-02-22" version="1">MNKRLSAIEHNNPSFIHRCAFAQIKIQSIRIKQESNAGPAIIDMAGSINRLLPYGMCSNSTITKWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2I3</accession>
    <name>A0A922L2I3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2I3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="9692" checksum="66C7E04A4DB5823C" modified="2023-02-22" version="1" fragment="single">NFYSILYSDKGKPKHNKSLKLKKIIEIKPGLEQLTMAHLGMNKDDSRYLEFTMNVTVDFKFQNFNLPLLNIHNQCGYGKLKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L320</accession>
    <name>A0A922L320_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L320"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8041" checksum="AB1B067AE37D721C" modified="2023-02-22" version="1">MISQIELETKCVVEVKGDQTILHYAPQQLTTTPVMVAKGTITSGSLSSSSTSQYPTTSPQPQQQQNSTLRPPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L399</accession>
    <name>A0A922L399_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SLC6A1_2</name>
        <name evidence="13" type="ORF">DERF_010178</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L399"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11496">
        <property type="entry name" value="SLC6sbd-TauT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF309">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="5 10" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="740"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="878"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="909"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="951"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="991"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="449"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="848"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="851"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="852"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9511746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1090" mass="122373" checksum="145B41264603A756" modified="2023-02-22" version="1">MLNIKDIHHHHHHKNIAANLADNHGNIGSNTVIDNGSIINNKININNDDEYRDDQLLLIPTDSSTSSLSSSSMTSLSSSFVQISPMTDISTENNNHDDDKNMVKPGNDNHEQQRKNEMDADNRMFITTKPIMTFDCFSLTSQESFPNGHHIDNKNLIELLRKGTASIAPCLNDNNNTQGNGDDDNNNINDGHFMMMKNANHHENHDQQYYKKHWLNLNKQKHHVRTTTTPTTTTTTATTNIVTNVSNHHHVCDDDNMGNDFIQPIQTLIKNNNNNKPRPPPPPPSSSLSMPPQSTRPSFASIQLLKKDQIGFHQQSKPITIDSNSSFSHHYKIQQQSLDPVISVNNNNNPFDHCDPFICYYPQQQLLERQNQFNMIKNQRKIDDEKNIVKLDHPPIDPLDFLERYRQRNNLSDESPINKISTSSLSSDGRCPSESQSFTNSTIAIISPKKNKKSINNGDDAGDDDDDEQSSTNGGSSVTIDTDQSQMERGQWSGKLDFIFSCISYAVGLGNVWRFPYLCYENGGGAFLFPYLICIFVIGVPLFLMEVSLGQYFHAGGVSIWNQIPILKGVGFASMIMIGLCNTYYIVIIAWTLYYLFSSINVPLPWMTCDNEWNTISCWISTVSGSGSGNNGESIESPPGSVSPAQEFWTHKALNISGDMAEIGQVQWHLFGTLILAWILVYIVIYKGIHQSGKIIWVMAMFPYVILTILFGYGISLPGALDGISFYITPQWHMLKEAKIWVAAGTQLLFTYGIGIGTNIALGSYNPTNHNFYRDSLIACLLSSFTSLFSGFVIFSVLGHMAYTMNTNVADVARSGPGLAFIVYPEAVTRLPLPNLWAILFFGMLLVLGIDSQFCTVESFVTGIVDEWPHLLRPHRKLFTLFVVFVHLILGISMITSGGMYIFQLMDNFSASGITLIVVVLFELVAFGWIYGGKRIYQNMVEMLDFKPTRILYYIWCYISPACLLGILIFSIVDYKAPEYAGKPFPWYGELFGFCIASASIIFIPTYMIYYLFIKSDPNQSWAERLINGFRPIDEQTTDRSTSKAQMIDSNHSNSMANSIVVIKSDNITCSSSLPSERTMDNSSLYQNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L522</accession>
    <name>A0A922L522_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L522"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF5">
        <property type="entry name" value="GROUND-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35939" checksum="D35B535AE90903C9" modified="2023-02-22" version="1">MKIISNSNLVTPSDYYLILSNTSSSSSSLLFNKYKFLVLSLIWLTLLLATNGDEEAGGVAYQYRPDEYPSLVSNPKLCAGSFRNPPTSVCDPDNIIKPEDAKKLDQLINVQQNETACLCPPCSNENPNGLLIKIALVRSINLAANQSIEKSVEQFADRTRLKWNLAKTCHHDVLVFVAITYNKVVISMGTKAENVIGMKEAQNIIENTQKHFSRNYIYEGLDSIVSSLQNQAQEYDPRLDRFKLRQGSLWFIILGAILLIIIVIVAYIQLKREKKNKTKLKNQDINLSDENLQRRNAIDYKKVNDDDDKNTNQQSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5C1</accession>
    <name>A0A922L5C1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5C1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="76" mass="8916" checksum="FE6A92E75DF3385B" modified="2023-02-22" version="1">MAMTQKFLLKKNFDYSTMVLYTKNSGKGNDHNNNGWMIMATKLLSTNVEIVEMMKRIYIRFRAVRFILSPHGRISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5J2</accession>
    <name>A0A922L5J2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5J2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="173" mass="19406" checksum="BCFB72B3B2970B86" modified="2023-02-22" version="1">MTKIKTFEDMVRRCTSTTYRRTTIAAILPSNNEATLLLNNDNKESPESPKSNNNKSNNNYASIKFHHNNQPQSSIYYISGLLAATRIMSNIVQSHTTPLSLTTTTTTTTTAKPEVNLMQIVCKDFFFKQQQQKASTIQPSSSSSSSSTSSSFFLLLLKDNNNNKKKQQTIQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L668</accession>
    <name>A0A922L668_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L668"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="335"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1035" mass="119634" checksum="2DC73354CFD0A9B7" modified="2023-02-22" version="1">MLTIVQCNLHILNEGNRPTFDTVRGQRRLTSCIDLTLVNDNLLDQINNWHIHDEIHLSDHRPITFTITDQCIDHQQNQSTTKWNTTNINWTEWSSDIEYQLHDHNLSATTINNINDTNELDLAVTIITVSIQFACNLHCGKYRHKRIRPAKWTSNQSLLDITKKQKAIYRKIRRCHNPFTIERLKNEYMIARQQYRDISQSLKNDDFNKYLNGQGPENCYQKVCRMLKNSDVMVARTIEGTNSPIESTTKLVNSLFPDDDFDDSNEQHEIRQFTKKWLEKNKNNTGVTAVSLLELNNVIHKFRDGKAPGLDGISPRILKNLWLSFPDLLLALYNACLRLKYVPYLWKSSIIRILPKPGRDDYSKTNAYRPIGLISVLGKVLERIMSIRITNHLISNGHMSDYQYGFIAGKSTDHALLNLHNDLESAITRFKHRSFDHTWHPFIINQLINYRAPKYLIQLIDAYQNDRRITASYGGVTCNKTTNRGTVQGSILGPLMWNLVVNDLLCKNFGLDVKIQAYADDVTMVVACDCIKYMPVKINKILDMAASWGRKCKLTFSESKTKIMYVSKKIARPIYPPVRMNGSIIDPVKETKILGIIIDHKLDYRPHIKYAIAKATRINRAVTGIARKSHGLSPQVLRMIYHSITEPILSYGALITGRAVKYQHIQKILRQMVTPMAQQAVKAYRSSSYISVTALADFPPIELFIGFRAAIATARTTGQYKYNDLPITVDINDDLNNNTTSKITTIIKEPSASPPFRIIVKSIKTTMGVGAAFMIFNNENIIGVKHFRLPPYCMIQQADLFAILKATNWINENSNNRTVYIITNNISTVQHINRIDRKNRQRLANELIDKSTDNIIVVWNKVDKTESWYHRLKKYAKVTANNRSRDYDYNRMPINYIKKYERNNMMISWNDRYLRDRFGTNIKKLCPNLHDARKFVPYIDKFVTQTLTGHGQFGAYLSKYDPSNDKKCCCGFRFQSVQHLINDCHMLNRLRHDYQISINNSDDPKEKTRLTAVFYGNIAMFADQQRRSVHRLHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7D8</accession>
    <name>A0A922L7D8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DRD1</name>
        <name evidence="14" type="ORF">DERF_005686</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7D8"/>
    <dbReference type="OrthoDB" id="5957871at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF187">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-2R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="73"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="503"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="706"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="861"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="872"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9522083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="894" mass="102245" checksum="1A5899EA1B539154" modified="2023-02-22" version="1">MEFEEQSLSTISTLLATSIDEYISSSSSSSPSIEEKSSSSSSLTFLSTDSLSIYLKIIIGIILVIVILISIFGNILVCVAIASDRRLRRLGNLFLVSLAIADLCVGALVMTFALANDLMEYWPFWPQLCEIWIAFDISCSTCSIINLCAIALDRFAHIKDPMLYNRWMNKRIVIAAVSIIWILSGLISFLPISLGWHKPLPSSSATTIVNRMNNTSNLISPSTMMTIIELNRGYDHHRRIDKRFSFSQSPEIIEQQRQKRSIDRQQPVSEFDYRPLFFTMFRQQNISTMATIGRAPSFYLPVPIFAENEQIHSETESIEDEIDRDDNQLKEQQVIFATLRHSRHYSTVYSNQINDQIHHYEKQEKKSDKIGHKNSISTSSSSSNCINDCDTNVESTTIIPQIQDLPQCALDLTPTYAVISSCISFYLPCLIMLCLYARLYSICKQHVKTIKSMTKMIAPCPQPGFITTTNTVMTAEIRNQQQQQNPLLTDSIKMTINHNNNQIVTDGQNKRHSSTTTNPGTLNHHHSNQFQHQQQQQQSHVSEHKAAITLGIIMGTFLACWMPFFFMNIVAAFCKTCIPASVFKLLTWLGYFNSCLNPAIYSIFNTEFREAFRRILVRYVFSSDMSQTCNRICQNSCSSMGKNRQSSTLMRTKMASINVDQEAGDCFIDDRIDRHSLQLQSNQYEQQILGKKANSSLILHQSLDHNSHHTLSNNNDEKQNIETQQSSSSDMTLKSNGHSQSSNVDTKHIDDEDDNDEKLDNNNIINLQNKVDKSRKSNEQSTVKRQSNRQYYHHHHRQRNYNNQQLYNSYSFDHCYSTTKLDRKIDTTLIAESPHHHHHRQMSSDPNINLALNRNLYNPNQNHNHNHHNQCKSDTSATSMKTTMIKQQNSSFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L864</accession>
    <name>A0A922L864_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">E2K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DERF_007584</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L864"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="17">
        <location>
            <begin position="102"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="178"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9516867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="482" mass="53309" checksum="B204F9B4268DFFA5" modified="2023-02-22" version="1">MKKKMFKYTKIYSYSLINRASRLVTFKQSTTRLFKPQIESKLNPQSSLFDFNVIRCSTSLCSNNIFNNNNCSSNCETNALLFQLNNKNRRTFHVSARYYNEIRDVVVPALAESLSEGDIRWMKAVGDQVNEDEVVAEVETDKTSVPIHSPVAGVIEEILAEDGSTVQPGKVVLRIRVGASGGGATAPKSTETPKSEPTPESSSPSPPPPPPSTPTPEPSSGPISSTPVSDVKSTTQTMASPSAEASVGSSRKETRVKMNRMRQRIAQRLKDAQNTYAMLTTFNEIDMSNIMEMRNRHKDTFQKKHNLKLGFMSAFIKASAFALQDQPVVNAVIEGNETVYREYIDISVAVATPKGLVVPVLRNVEKMNYAQIERAISEVGEKARNNQLAIEDMDGGTFTISNGGVFGSMFGTPIINPPQSAILGMHAIIDRPVVIDKKIEIRPMMYVCLTYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8T0</accession>
    <name>A0A922L8T0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8T0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="388" mass="43211" checksum="BFD2C661BBDBD7BB" modified="2023-02-22" version="1">MDKNSRSTLGKKDLGNGGQMMVPFQGIGTRLRRSRSKDQSTDNLSSNNLEIANLKRLQLQQQQQFILSNHQNNGYNDGGLTNLYSSSGTLERLKYYYGNAQQPTSTAFDHHNSSFINSSIPHQQQFDQRLAMKNGNSGGSSLALYDESRLLSQQHQYEEPQYLIDANYRTRQQKDLYGKFNNCPSKLNDLNHRNLTIIPPSKLFAKTLSTSSSYKQPPSSTITYDSCLIESGSKSSQSTTTTSGIGSSNNNRQSNNNNNNGLLNDCATDYGGDTDIVGSSSSPSCSGGQCSAILTTMSSSGSDDVQQQQQQHPATTTTLLPSSNNLIHHHGHRRRRERNRKEQQQKQQERKTKTNVGGGGLNEIILLLYNLSFQQSNFHNMPKKRSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8U3</accession>
    <name>A0A922L8U3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">c-SKI SMAD4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_000615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21079">
        <property type="entry name" value="DHD_Ski_Sno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.20:FF:000002">
        <property type="entry name" value="SKI-like oncogene a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF25">
        <property type="entry name" value="SNO ONCOGENE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01046">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="c-SKI SMAD4-binding" evidence="3">
        <location>
            <begin position="436"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="960"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1278"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1443"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1478"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="908"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="960"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1014"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1310"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1368"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1379"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1517"/>
            <end position="1542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9526538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1548" mass="167317" checksum="BECDCD35D910A8A9" modified="2023-02-22" version="1">MTIMQQSHAQKQQFHHHHHHNHNHHSSSIQTSSSSSVSDSIDSQSDCQSSIDCPVDLSKLNTVEQQRSVIFPPSSSSSTSTSTTNINKVDTNSLDTNHHQYQSATTPIVMDLSVANVNNNNGESQQQSSTTPTAALESHSRHIKKVLKHYQAAATLSLNGPDWFLPIVSSFSATTTNGNSSMTASTSSPSLRVIEASSSSSSSSVDNGALELTKTSNSTLNVDNKVGTGNVSTTLDLRTTTNSSTTMTTTNKQTISPYLSTIGQSTCKALSTNRSSSSSSSMKDLFDPLLAPPPFPIQQPPLLTPPDQGPSRSERSETRLEGEFIACFMVGGERRLCVPQIFNIVLRDFSLQQINQVIEELQINCSTCTRDQMEVLKLSGDIPPMAPSCGLITKTDAHRLCSTLLGSATSGSGPGGGNNNISSGKAGLDFHNTPYILVYHECFGRCVGRYAPSLYTHQSAQCIQCDECMASFAPYAFVCHSHKPRENRTVHWGFDPTNWRSYLLPIEDLASYETSPLMAISNNLSMLLADSKNLSHLLLLVQSSKSTSSSSSSSSLIPPCCTGGRKSLKSSQSSMTAVIDALYQSIGGGKNIDNIRSIMKEMKCRFSKQTISSSSTSKLNSSSSRLMQPLIQSGNNHTKRKDMFDTPILSSSSSKSSSLLMSLESTLNQHQQQTSNKRIKSEPLDLHHPSYSNCIQVGAANAAAAAAAAAEGVGGSNCQSTNNLQTMSPFVYPFLQSYLTSGMMPPPPQSLTQKQLPSTSCSNDEKQQLGQKEFLMQQKQPTTNTTTNYLSALLNGAAAAAAAAAAASGNSSSSSSSITNNSSNALIANILNTKSSDSSDSLSSMQNKLQSKALSSSLFTANNNNNANHFCQSNPLVTMMINGANNAGRLYNSFYGSSNVDYSSIVNQSSRMASSQPPQQQQTTASSSSNSHPIDRLLGDSLLLVNQRKGELLDINPLKSESQRCSTSQSPKETLTDTLIGDNVRTSLSSSSSLLSAPKNLNSSSHQLYESTAIKSSTNQKDNDVDNTSQQSHGDLSWPFVAGTSVTHQNMQSSAANNHLKWNQCANKNLAALISPNTLMEGNLYNTIHMLQKMRHLCFELGMTPNLFEPSSSSSSTSSSTNRNFVSKENAQLEVETRIQLLGQLIKDSSFDALKRNLSMIEYLIDDILVHFINNNHQLPSTGSLIMERFKKQMFTNILDMLEGIFADKLSNITNQNAEQQLSSHLKMEKIDNETVTVAKKTMSSSKDCDDIKTCQQQSQQNIADTHGIDNDHHLIAHRTDNSSKVNKNEQPSSDFDSISKTTNADTIQEPESVQSSYSSIQIIEEDETHSPTATINSQKDEENDSQSIKSTIADNEELIHIDNNNDDNNHSMREKQMSSNSTTTTSIPTTIASESSIVDSMVAHHLLTNGYHHPHRPTIEAINEQLSHAISTLAAAAASVSSTRSTASPTPIRSSSSSSPLSPNTVPSYHSNINFLIGNSLNNQNNHHHHRMANNNNNNHLHHSSNGLVVGDDVVTGNTASNTPTTTNSLTQPSTQPPLLLATGSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9V5</accession>
    <name>A0A922L9V5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9V5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="108" mass="13009" checksum="4CA727B0FD165DC3" modified="2023-02-22" version="1">MLVYWPWTRRVGISFLFVGFILHLYPVISFQKLLSIILLLSYCFPPRLVQLTLILGLIKCSFCDNTDMVILIRWFYHPKFCFEYYTRIFHLVRRDFDVVAVDGTHDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9X1</accession>
    <name>A0A922L9X1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9X1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="113" mass="13359" checksum="5F5F099A97C099E4" modified="2023-02-22" version="1">MAMYKCEDDQAEMPRGFKHLICQFFEVSIFSNHKNWFTKSRRQNILVHQISHQYVYYAAASIHVWGIDFGIVVRDDASIIKSINSNIPIRIKITYIYQSIMDIFEEPNNLVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAJ9</accession>
    <name>A0A922LAJ9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_004842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAJ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1090"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="883"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9521170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1117" mass="121758" checksum="A3DC5BB8CCE18DB6" modified="2023-02-22" version="1">MMLNSATATANHPFPGPPHFVDLHVNPGESVSIQFIDGNETVLRGPTTIKMISQHAFPPMPMPVQVPPGHMIQQIVDEHGTLKHIILSALTTAVSATGTANNGGGGSNGGTSAGTATPSSASNTASATSAFISNPVAAASHHQQQTPPQPHPFCCCCTQTCVTSPSQAGLPQPAAAIVVGPNQIIPQGPPPPVAVFPAVPPPPLSHSPATSMAGSVGPYGPPPTVAAVMNSRSSTISGRSGGGQRSSTNNTTSTTGHRNFSSPNKHRSTSSSTSASTTTTNYNHNNNNQSTQSANVNYFMTNNNNNIGTANHHHNKDGNYNRRTPPSSNTAATIAPTSSSSSASSSSSSNSRYSKSSSSASTVVVAAAATAAASASTTATTATGPDNIIMMSKYNNNNNNRYQSGSAMYQYDRSSTIYDHHYHHPVTANNNNNNEIVIHNGKYMTNNNNKYNSNDYSSSNNNHISSSTLDQTIDNNNYYHNHHNNQQQQHHNLNKYYHHHNHSQHYQQNDHYHHPTHHFVSRKKLPLNSTTNSIHSPRRLLSEVNKDSGHTSKNNNTGGIKVLPNISYLEIGHNGGIEHFEQKSDQQQQQLQSMDEKVSARSSSTNDCDSIRKQSKKFSLDSRSKVTLLSSSGSNKTANLTSMNQSISSAKNSDERCSLNNNTAKNICDQNVQVPIIKQQSNRKTLAAVDENANDLISKEQTKCQQESKLANSNNNQQPIIVLDDDDNDNDHNHSDILLHDPSDNGKLSSPSSESAKTSKMMAVVDDSKDKQQSSSNDEECIESKSSNHHHQTSDNKSIIANGRINNMATKLLSENHHSHNIVDSASDTHGESDKTESESDESTSMTNQRCDWEQQQQQSNINQTAKSDNVSTPSRSPKHLLPKKEALTLTCSNVTSTSVRLKWHFSNPNEQQYQQGGTEQQTKRNYIVDMLLTNNHNQSSTNDDATNTMSPTTTSTKMVHQGPNTSYKVTHLQSQQEYTFRVRTSTETCWLVSNCLTIVTPESTPSFNNRHRNRNNSKQLHHHHNHSSTMTCASPSSQQQQQQLVYHQNQLINTHHDQKHHTNKSQLIASASDLLLNPTNVILSADQGYAIILVVVFTIISLIVAVLINHLLANHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAP7</accession>
    <name>A0A922LAP7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_002511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAP7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF18">
        <property type="entry name" value="RETROTRANSPOSON, UNCLASSIFIED-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="471"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9528578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="772" mass="87092" checksum="624BEBEC0D98DB7B" modified="2023-02-22" version="1">MNHFASVSPIPKLSKNWNLWYRSVELTMRSLKIWKYCAGTLAVNPDELADSGRAMAIILGTLSEEDGNLVMSCNNPEEMLYLLRGKYEGSRSASIMALKGEFHTIQFDDQLSFFGKIREINTKLMALGSSLDEIDMCQRVLAILPPEHHDIVGQVRVMSEFNMDNQEIELKLVKIESLLRQRVKDRESGKSSVKQSNESLDKSVTLAATKSDRKKFIKCHYCHKMGHMKKSCYKWLKEKKSDNNNNESNSKSVSGKTVLAIVKESEMNISNRFYGDSGASSHIVNKREWLDNFRPCNESFDTAGGRIKIIGYGDLNCQFHTGTEWHDVLVRNVALANQNYNLISIGQLERIHEDLSVIIGSGKMKIMKNGKCLLTGYRSEEINNLYHLPIRVVDSSSPSFMNVSLISSSTADLALLHERFCHVNKNTIIKMAKSRIVDGLSIIGSDNMGFCNACNDGKLTDVSHRLSEKLSNIKPGQSIHIDIAGYTDQSLHGNKYYLICVDEKTSYIKVEFLKNRDDVFNKFIKIVNQIKLETGNNVLKIRSDRGSEFTSNKFRGYVDSHGITHQFACVGVSQQNGLAERHVRNVNDHATSILVSSGLPKILWDEAVNCSVYVLNRTMNYKNEVPYNDWFNKKANVSNFIVFGSRGKALNDEIRKFESKTIDVYMVGYQGDHIYRCYLPNKREVHLVSAVKFEEIPKCRSVAYSIPDDDMFSVQSTSGFTKVNGDNDDDDGNDDDDDGDDGDSNGVVDVSKRGRPLGSKNKTQNKVEIVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAT3</accession>
    <name>A0A922LAT3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAT3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9715" checksum="2375B90A8EA5F7C0" modified="2023-02-22" version="1">MVIRNELDTTDESMFQRLKENCEKEILAGYISCTNLPLKKQTKRDNIYLFLMVKRPSTRIFEAMNQILKPFVDEMKLLEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB35</accession>
    <name>A0A922LB35_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-protein transferase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CDC20</name>
        <name evidence="10" type="ORF">DERF_005301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB35"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="190"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="461"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9521665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="530" mass="59500" checksum="F4B59D9BEBB1B863" modified="2023-02-22" version="1">MDKSTNILSNQLENLSLNISNISSLSFNRSMKNVKTPIKSLKLTNAQTSYTPGSGRKTPNRQQHHHHHGKENKKSSNKNGNKISPKTPINGDRFIPDRSAMNFEIIHYLVTNHDDNSNNSNNVPGDNSTKQMDKIIGADLANYRILALNNGGPKPPEGYLNDKKVVYSCTKSSSKTKSARYISKQPERILDAPDVLNDYYLQLIDWNSSNILAVALNNEVYLWNAMDGSIVHLLALDEPDYISSLSWVNNNDTHLAVGLSTGVTQIWDVNKSQRLRNLTNSSSRVSCMSWNNHVLSNGTKDGEIFNHDVRIATSRIGTFRAHTLEICGLKWSPNGQLLASGGNDNIVNIWPNCFMGQNNSDTTNDSEQPLFQIIQHQAAVKALSWCPWRNNCLASGGGTNDRMIRIWNTSNGQCMYSVDTRSQVSAILWSEQYRELISSHGFANNELIIWKYPQFTRVTELLGHTARVLCMAMSADGSTVVSLGADETLRFWDCFQSDSVKKKRQKNTKKLTDFQQQENIMSNVSAFHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB60</accession>
    <name>A0A922LB60_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZDHHC13</name>
        <name evidence="16" type="ORF">DERF_001429</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB60"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="8" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="11" id="KW-1053">Target membrane</keyword>
    <keyword evidence="8" id="KW-0800">Toxin</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="448"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9527412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="675" mass="78011" checksum="CBB90DB7EB7B945B" modified="2023-02-22" version="1">MNPNNDRDSMNDSNTNLLGDDGDKIENKIDKLFEIHSENESNDTDINERFSHSSPTPPPPPAPDLIPQLNQQHSNSDITTEIVRATQYGNLDLCQKIIDSGRYGVNQRDHENVTLLHWSAINNRLDLVNYFISKGAIVDAIGGDLQSTALHWATRQGHLPMVVLLMQHRADPSLLDGDGYNALHLAAQFGHTSIVAYFIAKGQDIDAPDTNGMTALMWSSFRNNSIDPTQLLITLGANLSLTDRNRNTALHRAVLARNPIAVSLLLKHGANPNLKNIAGDTPIEMSVKFHAKFIQTRIKIAPNTEIRIPKWRDPQFRHYVMALTPFIYYYLFGKLCESDLMLSSKALLLIMLVGLLYLLIRYMFDAKQLNVLAISLYLSTKIWLYITFFQYFLFVFSSFELFIFILCSTGLFYSFYKCYHSDPGYISNSREEQIKTIIELGEHEGFDSSWFCSTCLIRKPTRSKHCSLCNRCVARFDHHCPWIGNCVGYRNHKYFIWYLATLSMTLFCYIVATIHYWDFLDDIRDDINESDRIMTNRKHESFVDVWSNVVTYNGWITWSLVNALIHVIWVVCLLFFQLYQITCLAMTTNERINADRYRYFKQNKRSGNIHNPYNYGFIRNFIEFCECRRLNMCLYKSPDLHDWRYVFENFEAMGRYDSDDDDDGGGSSSHDEINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB63</accession>
    <name>A0A922LB63_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB63"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9530201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="33" mass="3579" checksum="F9DE60DB9D7C48D8" modified="2023-02-22" version="1">MMNNGGKNPATISSSSFNDERIVSIVNSNFISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB75</accession>
    <name>A0A922LB75_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB75"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9530246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="471" mass="54639" checksum="2289648D7FD77C8C" modified="2023-02-22" version="1">MNNKMVKISVYLEDLETIKEYRRDTRLELDVIADSIDLLIREQNIRRLLDEYYNLRMYCSNLDDWDRRLDQTVDDRIQSRSYTRMIRQSLDRIVDYFQQSSDGGINNCHLYSKMSSLLSPSSQSMISIVQHQQQQSSSYGNGNPVESTITNINHCLNNDCDDGEEMEKLKEKMQKSSIQSPPSQIVIPSKKVDEKQREIPKNMDWSKPPPKKFDYASSTENKESSCDSNSQHSSDLETAKLFEYLENHYSEFDKKTNPLGNSKNNLSKQTKSNKSLDAAAAAAVIVGDVRQSKQRQQQRSSSSAAVANSEQNQNRNQTSKANSSSISSPPSSSSMNNESLVNKKDHKCLFCGRVGHNDYQCNQYYSMEQRQKRADELNLCKRCFDRLKPGTKTHESSEQCKRQIECCNQSCHQKRYTHHSNLCFEFLKFSEIHHSKQNNDKSKQNQQKNQRGRNINVDRTFVRRMDYNEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB89</accession>
    <name>A0A922LB89_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB89"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9530291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="220" mass="25630" checksum="AEF46CF171475CC1" modified="2023-02-22" version="1">MYRYGYYTNIWPLNTSWFDQFARKLHIDRQNTLDFNYFLEQLWPIRTIRNLSIRIKRSPKRVIGGTVDEISIPATTKSLSLSSWPSSKLGSDYHHNKSNSSSSLIESSHQSSLASIIDDIDKQQRNEKSLFDIQELSTSLLPQRSLSRSLSEKIEIKIKIPKIQMKRKLIHHHPQQQQQEKQLLKFTSKFVQQLKTSFDIEKQNLISTTPAPSSVVNMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBI8</accession>
    <name>A0A922LBI8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBI8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="99" mass="11105" checksum="7BB677237E029E69" modified="2023-02-22" version="1">MLVAITPLNTILTECRTVRRTLGIIFLSWLSNPMFNFSGALMSSFQTSIRSSIMQTIESPHGNSDFIFPVLDRGSKNSSRDKIRSLGKNLHFGSIKWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBK8</accession>
    <name>A0A922LBK8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin-L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CCNL2</name>
        <name evidence="6" type="ORF">DERF_003558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBK8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000031">
        <property type="entry name" value="cyclin-L1-1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="113"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="228"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9529688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="647" mass="74162" checksum="39789E7916CED52A" modified="2023-02-22" version="1">MAIFACYFAHQKLINSMETKNSSISSVIKNDNDNKEESNKSIADNAVIDGAINKSSSSLTDQQQSSNNRLKYGRVVILLENPILPKETILNTPSKADNLDPDIENDLRITGCKLIQISGILLRLPQVAMATGQVLFQRFYYSKSFVRQPMEITAMACVVLASKVEEAPRRIRDVINVFHNMKQIRLKQQTVPIILDENYIYLKNQVIKAERRILKELGFCVHVKHPHKFIVAVAQILKNESNVDLIQTAWSYMNDSLQTNVFVRYPPESIACACIHLSSRILKVSLPSQPLWYEMFNVDSESIDDICKSILMLYTRKPLDQEDLEMKVEQARLKLEAEKVKARALAQRNNLLSTEAINSPVLIDSRSNSPSVVATDIIANLRFSNKPMIIDGDEKILKSIRNDDNIMEISTQDSISGGNHVNQQQDNVGSEHSSISSSSSFKLQKSPIKSSKEETSKSSKRLDYDYNHSSSFDNDHYKSTAYRSKKNGHSICSSEQDDYYSNSRDDHVKLRNEQKEYRNDRSPLVPRSFISSKIVSSNSNRRDHRNRYYQEDSRSRSRSPISTSSSYCDNQYSSSRNYYYDRRNDASRSSTTGKNRSNDGDRRYKDDPRSTSSNHHHHQRHHNYHESPDQSSYSSRYYHKSSYSGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LC22</accession>
    <name>A0A922LC22_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LC22"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="6975" checksum="F49CB9853170A4B4" modified="2023-02-22" version="1">MKGSRHLLVKSLNGRRFSMTSVDNPGEEDFNKLRNTIRKVDVSSTEVHHAGPWLYSTSGINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LC54</accession>
    <name>A0A922LC54_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LC54"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="96" mass="11169" checksum="CC1C0BE35D1896CB" modified="2023-02-22" version="1">MNQTNKSELSTYFQLVNNDEQTQILSEETRDSVSFGQSNFDTKIQYTQIFTQTFGNRFQMPTDQALELNLVENMAIISLLSILTGIRVSIKFKMWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LC64</accession>
    <name>A0A922LC64_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LC64"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="145" mass="15499" checksum="FDF9ADC954DEF2C7" modified="2023-02-22" version="1">MTTVQMAKILNNEQKKPFQSEPTEVIATNIIAPATSIQPSTRKIGKRKKCCGIQKSVKAGKVERQTHPLLSIMKLASISFILAIVTMIIMAIASSPTGVEAKKKGFGGGYKKFGHGKGGFGHGKGGFGYGKGGYKKGFGKKKWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCZ2</accession>
    <name>A0A922LCZ2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCZ2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="84" mass="9680" checksum="72B6CBFDE1B53ED2" modified="2023-02-22" version="1">MKKNRFGRSISHWQEEEEEDDDDDENNEEIELKYEIQYATFNNNNNNISDISRGQVVFFCFVLLGFVYNAPLSSLSSSSSTTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LD91</accession>
    <name>A0A922LD91_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_002207</name>
        <name evidence="8" type="ORF">HUG17_10174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LD91"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7636204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9528250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="253" mass="28426" checksum="57AFBA95D99F4423" modified="2023-02-22" version="1">MANIINILKCDSLQESKEEFRKVVQKAVDDHDGHYFTVGLSGGSLPAILAEVLPTINTEWKKWRFFFCDERLVSFSDPESTFGAYRSIVVPKISEISLNQFITIDPSLNSWAAANDYLSKMKQIFSRKTEIDFPRFDLLFLGMGPDGHTCSLFPNHPLLKETKRWIAYVGDSPKPPPNRVTMTLPVLNNAKYCVFFVAGAAKAQVVKDIVVDGKLLPGGMVVPKKGELYWILDNESASMLPEEYLKKMSVDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDD2</accession>
    <name>A0A922LDD2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDD2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="7595" checksum="80C3DF03A578BABB" modified="2023-02-22" version="1">MATKNFSFCQLSSSGPAQAPVQTVHRTRPRATEGLALPEAARFRKQLAVPKASQFQEPRSTKSLAVPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HEY6</accession>
    <name>A0A922HEY6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_016720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000010">
        <property type="protein sequence ID" value="KAH9490522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HEY6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9490522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="81" mass="9814" checksum="78F2F91D2BA6DCDC" modified="2023-02-22" version="1">MINSQLKNEEINKQTKCEKSRKKIPEHEFYRLVNSVKFCKTKLQIREEEMTRELFKNQLKLNLLLKYENNLLALFINSLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKJ3</accession>
    <name>A0A922HKJ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_015848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKJ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9491113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="7293" checksum="B5F25FFF91685D55" modified="2023-02-22" version="1">MDDNDDRPDVLVVEYIPYFQDDNQHTLLRYWLQWSHKVQMYVKTVITRGKSTRKHVIDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HL64</accession>
    <name>A0A922HL64_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_013038</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HL64"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000508">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000094">
        <property type="entry name" value="Zinc finger protein 605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF48">
        <property type="entry name" value="ZINC FINGER PROTEIN 771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="375"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9497022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="438" mass="48881" checksum="9307CFF56E11A380" modified="2023-02-22" version="1">MSLSPATAAALSQAGKKPHSCTECRKSFSSVHQLAQHARLHTGERPYGCTYCERKFKQLSHLQQHTRLHTGERPFKCDCGRSFIQQSNLTQHMKTHEDSSSASSKDVDKNFFCPHCGKGFKGHNSLLHHQTKKHADLMNPTQIVEKQLGITVGVNQQMIPNQQQPQQQQQHQLLSQPITQSILTYTCQLCNKIYLDESSFKKHFEINHQHRQQQESLSSSSSSSSSTISNITNSSAMALATTPAMTTAITLWPCSICSIVFANEYSLLSHFEQMRFDPKHQKDTQQIVLQTLKQQHQQTNLQHHQQQQGQKVKEENFGEEIALNLNDILVTSLITNGIELETPATTTTTAVIAAPASNQIVSANMIAQNMLDNLSQPTNRQTGNGTTTHHQQQQQRFHNGSTLKAVKSSVPKATTVTTVQTSSLSNNSNTNNNSTYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLJ1</accession>
    <name>A0A922HLJ1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Solute carrier family 12 member 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Na-Cl symporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Thiazide-sensitive sodium-chloride cotransporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">DERF_015883</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Derf</strain>
            <tissue evidence="27">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Derf</strain>
            <tissue evidence="27">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>chloride(out) + Na(+)(out) = chloride(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:73887"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer; adopts a domain-swap conformation at the scissor helices connecting the transmembrane domain and C-terminal domain. Interacts with KLHL3. Interacts with IL18R1; this interaction is increased by IL18 treatment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLJ1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000018">
        <property type="entry name" value="solute carrier family 12 member 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF103">
        <property type="entry name" value="SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0868">Chloride</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="9" id="KW-0769">Symport</keyword>
    <keyword evidence="5 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="25">
        <location>
            <begin position="69"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="26">
        <location>
            <begin position="570"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="26">
        <location>
            <begin position="677"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00063035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00073714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00077939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAH9491151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1021" mass="114875" checksum="D15AE0303C86C39F" modified="2023-02-22" version="1">MEMNVTRRRSSIFPQYLRRSERKDSIFQSESTKILYPYTIDEKRPGDYQSDTNNDQESSSLKFGWINGVYIRTVLNIFGVMLFLRMGWITGNAGILGSIGIVLISTLLTFCTTLSMSAICTNGEIGTGGIYYMISRSLGAEAGSMIGIIFSLANAVLVSLNLVGAAETTVQLISSANITITNDIENDTRLYGTGFLIIVAIIPLIGMDWEAKAMFVLLIILLVAIGNYIIGTFIPPTSEQIALGNLGWKPQIFMTNLFGQYDNSLAEIFAVFFPSVIGIFAGASMSGDLRDPNAAIPKGTFLAILTTSSVYTILVLFLGFTVLPYATGDYEEMKNVTFPLNFNCITSENGCPHGLISDYQTMTLSSAWGPLIYAGIYAATLSSALGSYVCAPRIFQALCEDKLFPYIHFFAKGYGKNNDPRRGYVLTFLISLIFIMIGEVNSIAPIISNFFMASFCLVNVTCFHASFVGSPSFRPTFKYYNKWISLITGLICVAIMFYLDWISAIITVIVMCLIYIYISKKGPDVNWGTSTKGHVYNNALFSSLRLTHTKYHVKNFRPSILLLTGNPSARIPLVEFANNITLHRSLLMIGHIVDYDIPNHTRKKVIESQYEWMYKRKIKGFYLLLETSSLANGAKIMSQIAGLGLKLSPNIVMMGKLRICIKVILKIILKNSINFFSGYKSSWRDCVVEDLLDYYNVIVNTHEMLLGIIILRIQEGLDYADFFDPLQRQQQSIIDFNDITITADNSNNGNMNIKLSQIPESNDDNHSDVDGMNNKFSNAINFESRLSNAMQIINSNQHQSPQQQQQRMITKKNFEKMKTLIPRDAIEAINQFSNKQKPGPIDIWWLTEDGGLTLLIPYLLNVSYNWSDCGMRIFCLSKNTENIESTKHNMMELLKRQRIPFKELTVIPESELNPSEQSKSLFRSMIEKFMAKNDLNSTTTTTVKVSKADLTKHEKMTNKYLEIRDQLTLHSKSSALVVMTLPLPHRDIIAPLYMVWLETITKDMPPFLFVRGHENVLSCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLQ9</accession>
    <name>A0A922HLQ9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLQ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7273" checksum="109B7B2FD99B2A8F" modified="2023-02-22" version="1">MSYMLVFFFFQQQQTNERTVVFEKGRFFAVCVSDGFGRRTPGLSSVAAINDYHDHDDDDDNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMV0</accession>
    <name>A0A922HMV0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Tudor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TDRD15</name>
        <name evidence="4" type="ORF">DERF_013703</name>
        <name evidence="3" type="ORF">HUG17_0954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMV0"/>
    <dbReference type="OrthoDB" id="9995375at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442:SF1">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7645416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9497742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="524" mass="60191" checksum="989E08A358C48280" modified="2023-02-22" version="1">MDSNTLNIYKKLVEAKKQIDDALEELVNLSQTKTEVAVKIVNKVPEKSIPNAVPSSTTPVNGIDSNISGGDSISGGDSVSGEKSIVGSSNDDKSLKTNGKIDHVAIADNKPLDAVKKFNYQDGTLTLNLVYSSRNFYVNFDYDKMKKFYTKFNEDYLLLNKKSVELQPYEIVIDGIYAVLNQSDETYYRGQVIDFCPKDQVKIFLIDYGDDMEIDRQQIYKLLPPFDKEPDFALNCFINEKWTEDFKRFDSALIKYLEDGVSLEGKLLNPLPNCHRIPISLHIQLPGKKMDKFTSIDHNVDVYDFIDQYKFNYETFLEKNKIDWTKLSKSFHMLDKITGFSKSLKMNKALIVKVEDIDNFLIITDHSHSNSQLNNFVTNFSNFYYPSRDFMLKDDISIDLVVVKHQDFYFRALILGGNDDGYEIFAFDIGFICTVKKSQMYRLLDIFSVQNYPPFIHCCRIHGLVPLKENWSSIAITTLKKFCNQSLDIIVRGFDKGKFQIEIFNGGMNVRSTFIRCRLAKSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMZ8</accession>
    <name>A0A922HMZ8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014481</name>
        <name evidence="2" type="ORF">HUG17_6683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7644321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMZ8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7644321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8753" checksum="35D164BD2CD200B1" modified="2023-02-22" version="1">MLRLYRTLLIIWTIIMINIQSMIVWSMGEEKFLKGLIIGLLFAQNKRQDSSYSSSYHMPVYSSPYHYRYHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNY9</accession>
    <name>A0A922HNY9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phospholipase A2-like central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_012100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phospholipase A2 family. Group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNY9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04704">
        <property type="entry name" value="PLA2_bee_venom_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12253">
        <property type="entry name" value="RH14732P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05826">
        <property type="entry name" value="Phospholip_A2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Phospholipase A2-like central" evidence="12">
        <location>
            <begin position="401"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9501240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="556" mass="62812" checksum="3CF89DCCACE664FD" modified="2023-02-22" version="1">MFGQNSSFHSLATTMLLLSSLMLITIISNGSCWSITYPFYRLFSFFTSSSSSSSSLSSSPPSPPSPSPLLSSSISSAISSLPSQQQQQQQTELIITNTTTTSASMTISTTMTTASTMMMMMMTTTEMPKTSISNNNDKILRPNNWHHRLHYHHPNFRLNHSEQEKNDVGDNDMAADTIHLHFNDSKMTNDFHVHFDPFSNKSSSTSPTSSSSENLNEFKGKNDMPINFEPRKPFEALIQNDKTMADLVFDHTGRDLIYCELFDLEREPLPVRLPMVVGDRRPLIVSHKTMLEAVRRCTQLAMIQHQDVFIKRYTNQTTATTTAMSMMMMVTKPTNESSSSTTNVDDNNSTTIMSRIFSNDTITGEQPLFYNMTNNKMAQSNNAATPYEMNLQHYWTFWRGILPGTKWCGVGDVASHYEDLGIKLDIDLCCRAHDHCPIRLKAFRTGYGVFNLSFYSRLHCDCDEDFYNCLKKSPNSYATMLGQFYFNVLRVQCLKQDNNIPPVSDSSDTTPPVSQQVVCRKHRITTSGTNECIEYGIIPESATNGHMKIVPFGRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPU4</accession>
    <name>A0A922HPU4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_013274</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPU4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9497276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="347" mass="39305" checksum="543E252675AA1A50" modified="2023-02-22" version="1">MDIFSINSNNDSSLKQVPLTCNGHTRPIVYLHFSTITENGFYLISASKDGQPMLRKGDTGDWIGTFEGHKGAVWGVVLNSDASLAATGSADFTAKIWNTTQGDELFSLPHKHIVKSVDFSKDDNQLLTSSNDKIIRLFDLNNINSGKIFYIYSNYITKQNLSIICVKDPENFFGHDDNIRQAVFSNVEGTKFVSCSDDKTVRFWDKRSNQEYFKLTFDEKPNGIEVTDDKSILSICYDQNVIFFDLSRMIQIKKFQAPTVIETSSLHPDKNVFVCGGQDFLIYKCDYERCEQIDSFSGHFGAVHCLRYSPDGELYASGSEDGTLRLWQNTIGKTYGLWKYVDSNETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPX7</accession>
    <name>A0A922HPX7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPX7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="69" mass="8048" checksum="834AEF4055E35198" modified="2023-02-22" version="1">MVDEGKLKNLLATFPLFNAENVSVDFTYYCQRQGNFLRQKCKTSMNRFIIVCQYNSFIQTSPKVRISMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ57</accession>
    <name>A0A922HQ57_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ57"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="169" mass="18228" checksum="E0830F86DF340376" modified="2023-02-22" version="1">MGIRFSLPPLILIPKPSWGFFRIVTVRLRLARSSVSDGISKSFTLSAILSNDSFNVIFNESSYSSAIIRHQKFLIKISATPVRRASAALCEMTPGSLIPSGSRYIYDPLTLPCASPDSERVNVIPYSSVVSYVKLYGSGAGSASACLAERDAVGAEYDATNGCDRAKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ84</accession>
    <name>A0A922HQ84_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">DLL4</name>
        <name evidence="20" type="ORF">DERF_013800</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ84"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045179">
        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043208">
        <property type="term" value="F:glycosphingolipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030718">
        <property type="term" value="P:germ-line stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046331">
        <property type="term" value="P:lateral inhibition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016318">
        <property type="term" value="P:ommatidial rotation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050769">
        <property type="term" value="P:positive regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048056">
        <property type="term" value="P:R3/R4 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016330">
        <property type="term" value="P:second mitotic wave involved in compound eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048863">
        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035239">
        <property type="term" value="P:tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000018">
        <property type="entry name" value="Delta-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000064">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000230">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011651">
        <property type="entry name" value="Notch_ligand_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21700">
        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07657">
        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 15" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11 13 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 13 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="767"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="19">
        <location>
            <begin position="340"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="450"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="489"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="528"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="566"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="606"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="644"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="683"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1055"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1066"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH9497845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1079" mass="121998" checksum="909335C0672333C6" modified="2023-02-22" version="1">MDRLSNNNGDDDDGQIIDDHHQQNHPLSIYHRSMMINHHWSSLIQPQPQSRTTTTTTTLLNNVNYSKLYRTTVMNDDDDDDNVVKMSTTTTTKTTKRPPSSSSRLLINNSNSNHLMLIIIVIILIHLFITHVSCLGIFQLRLDRFVNEYNRDASGRCCGAAAAAAGHNNTTTSTTICKEKCQTFFRICFKNYQANIDTNSNCLYGEKLTPVLSPITTATSDSHHHHNHHLNHHSHHSYYNYTIQFPFNFTWPGTFSLIIEVWNNVTTANTTTTTNINTAAAAADQHNKKNLNSKLPSWNSTPNLIIRSFESRRNVLAMNNEWTHYESRINHTLLQYSYRIQCNDNYYGNSCTIKCTPRNDLYGHYNCGSNGEKICHQGWTSEYCDKPICRSCNETNGSCIRPDKCQCRMGWTGDDCQQCKQYPNCKHGYCNVPMECICKEGWGGLLCDKDLNYCTNNQPCKNGGLCTNTGESFTCQCPPGFIGEYCEKELDSCDHSPCYNGGTCKNNAITNYTCDCPIGYGGRHCEQLLSVCSNNPCENDGTCIDGPSGFLCACKLGYSGSRCQIRQKGCSPNPCHGGSCQISNSTDETYSCECHAGFSGDHCEININDCESNPCLNSGTCVDEINTFRCRCPPGFVGELCELNIDECSMMKPCLNGATCVDRNNDYLCICPPGFTGKDCSINIDDCVNSPCFNGGQCHDRINGFYCQCHQNYYGNRCEFIDSSSTTTTTTTTTVTNILLQNSSLPFWAENHHDNSIKLSSTTLMSIYSLAILLLAILFVIIIIIVCKRLRRYGIKLKRRRDEAETRRQNEHNAIMNSMNNNNNNNAKYLDLNSGTTTTTTTNVIVNSLHRPASIHQLNMKCQPKITNEYVINNQQFNHQFNKCATLHNGFRAMNLNNNNNTMKEKMINCGTASAATIDDPYMHTYEQIQQQQQQQQHYKSKCNLLSNNLSMNNQQQQQQQLYNVDQYSMMKQSNVDLYKSDFLIVANNNNNDHHHHHYNTSVENNILTTTISPSSRMNNNHHHYGRSRSVYNVILDDNNVVDDDCNNIYTQPIYSNNGEHKDQKINTNNNNKLHATEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQD4</accession>
    <name>A0A922HQD4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spp2/MOS2 G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_013858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQD4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25088">
        <property type="entry name" value="GPKOW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="4">
        <location>
            <begin position="173"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9497920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="456" mass="52190" checksum="9AD57CDE356A226B" modified="2023-02-22" version="1">MADEEKIENDENKSTFKMTGFSFKKIAKPKSNLLTTKQLPSINDLIDIHDPDDGHGNDDKGKDFITSIDNNEIQCSNDEQQSIIIPLIKVNKYRNDKSRTCDSAEASPQLPVKNEDDCDDDDDLITKAKQELLEESRMIDDDDQLLPAWKSLMINKLPDEFKNDTKLDISMRPEVPKLNDYEQTPLNVYGAAMLRGMGWKEDGPIGGKRKAIAPIIEHQLRPRGIGIGADISLRKQLEQKNNFQKTTTGGCHVCVEFGPHKGYYGIVENLSGNESIYVTVKLRLMNDSVQLLQDFVRIVTKQEYDSESKSRERRQRSSSRDERMNYDDDDGGGGNNDDIWIVPKIRVQIIDKNYKNGRYYKEKVVITETRHNECICRAKDKKILSNITQSMLRTVIPSLSDPNIYVMILRGKYRGKLAKIKDVDWKHEKAMINLMGYISKPFAIALDNISEYRDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQK4</accession>
    <name>A0A922HQK4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosolic Fe-S cluster assembly factor NUBP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NUBP1</name>
        <name evidence="10" type="ORF">DERF_013623</name>
        <name evidence="9" type="ORF">HUG17_1029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQK4"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7645491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9497651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="323" mass="35774" checksum="C1E4EE289FD5EE30" modified="2023-02-22" version="1">MSSSEPEHCPGIDSEQAGKSAACAGCPNQGVCSGGELRSAAKDTEQDYYEIARKLSSIKHIIIIMSGKGGVGKSTVATQLARFIAFNDSESNVGLLDVDICGPSIPKTMGVENEEIFNSASGWSPIFVEDNLAVMSCGFLLESLDDAVIWRGPRKNGIIKQFLRDVDWSDELDYLIIDTPPGTSDEHLSLVSYLKFCQNVRGAIMVTTPQEIAQMDVRKQIEFCRKVKLPIIGYLENMSVFVCPKCSKENYIFKSKSTRPSTLEEKYGIKLLGRLPIDPIIGKSCDEGKSLFNDNNKLLDNRIHQAFEDLWNNLCKEINQSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HR82</accession>
    <name>A0A922HR82_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_011965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HR82"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="619" mass="72688" checksum="A6A7D82C974C0068" modified="2023-02-22" version="1" fragment="single">FIQLKMGQMMTTTSMERPPYHRPGEHFVPYDANSWRRLSSTYLNQLMSNGKLTKDELEIIELERYWRNRKQSNYSNHHRRSYSLSPVEQQQQRRRQQLYNHGGRLNGASSMGNLTASNYNENVGHSFHRQTPVLRNFQQSSHRTKKGDSRYHSLVNVSSIKPTRDNIEKLASNLNDPIDYKDVDHHQSKQHHRKPLSSVRTFQNEHFSPHDSSFSSYDSSNQSGSVNQQRAGRFERNKIGARKTMINSTSSGYNEKNDNNVPVKNEPQKYPANFRLPDQNREPRKFQEYFPKSASNHHRLLSNDKTVKTEFQNQEQEPFLNHKDNHHEKFTNDSPDSDFTRNDSIRTTGDRRNFTPDPMCQSTERLVEKERRQNNNKLDSSFKRRQQQSLAPDFRISSQEHLDQSYKSIQTYDFNVHNNNNNHSATNNRVHFNSNDDEQKRNGSAQLMRHNQQQRQQNGHSIGYFDTGHINYYSNYYQSFDRPHLMFSKIIYIILLVANICLVIWNSIYMHFASIKIKLGEPIDGRLYSMSHVQRHLWQAIVIAIISLNCITTMVAIYATIRQKYWPIFTTTILFYLFASFGSFSEFLRGSISSWLLPLICGHFGIIVTHHIAIDYYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HST2</accession>
    <name>A0A922HST2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HST2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9507051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="280" mass="30411" checksum="9B3975E66F967606" modified="2023-02-22" version="1">MFQCLGRWSSLYTCSFITIASALIHEHHSSTVSPSPPSLSIHGQTHSPTAAIVRRLYYSPSASGQQHQSPISSRTNPYRSMMHLSHSNNHRIVSTATRIVGSSSKGVAKVTPISIQSPTFDSTIRLTSRPTSTILMNDNNNKNNRLLQKPSTSLIQILEAMDSNNSSQASTNTTTTTTTTTTTVGPIINTISQTSHRHGKSLQEIASTSTTTTASITTTTKTLPPINNSSHYNENINNLCFLSHGGSSETFTVNEAVEIDSVIGTIKVFIMLLLFITQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSU1</accession>
    <name>A0A922HSU1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SPCS2</name>
        <name evidence="11" type="ORF">DERF_011766</name>
        <name evidence="10" type="ORF">HUG17_9962</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSU1"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7643271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9507063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="183" mass="21348" checksum="0389C7F7BAE00B36" modified="2023-02-22" version="1">MSDAEMIEIKPLDKWDGSAIKNRLDDAVKFFFTHTNQYKENFILIDIRLGISLMAVGVAVFALIWDYMNPFPTSRPILLICVCAYFVFMAILTIYTTMIEKGIFLKAKHGNKSITVSSYMKRFDDQYQLLVELKTNKNGGQPNESKLEDTIGKWIDEEGYFLERKFEDDLKRLYSRMLNKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSV6</accession>
    <name>A0A922HSV6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">USP2_2</name>
        <name evidence="5" type="ORF">DERF_011404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSV6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF46">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="96"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9506685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="404" mass="47122" checksum="23D842EA3B1C200D" modified="2023-02-22" version="1">MVFEIEITSCEYEGNSCVNLVNQQHNHKGRHDDDDDQQHEQRLRSEHNDDCSGGGGGNDVHHDEQIIKEEVDSSEGPMTVVPVSNPNIFYDEPKFVGLKNLGNTCYANSTLQALYGSNKLRQYLLNLQHPSTTAGGGYAVIKPEEFICEFRLIKPQFVRNEQHDAQEFLTILLECIHQEDNKIKKNKLAKLNVEPKNAQEAWQLHLERVDNSFYSRLFVGQSESVLECFECKHSSLSWSSFWQLNLHLKNDNDNGNGDRELSIQQCIQEYMAWEILNDATFCENCQRKQKSRKRLTICRAPHYLIVHLKRFTHTGSKITRKVTINQTLEICDKKYDIYSCILHRGTETTGHYFTLVRPYYHSWLLFDDESISNDTQKEWVEHWLQNYSYICFYRAVANKVIAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTE8</accession>
    <name>A0A922HTE8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_011660</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTE8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="709"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="712"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="728"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9506955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="748" mass="83973" checksum="76A0AC55ADDCAED9" modified="2023-02-22" version="1">MGTRLTTLGADSGVPGFTRIFSSTGIRKSFWIGVVLIFITLTVRDLIDLIKDYVQYPVTVNVRIADSRVLPFPAITICNLNLVHRSRFCAAKNVEKPEIIENILCAKIGDMLNQCKISNMMEDLMDQGESICGLKKTSSEPGGSNTNRRGPGRRGKRQLKLQDILKTVREVGNAVRGDGQKGSSIIDIYNDFQESVKSMADGSGGPLDETLTQLANFLGFNVSNSLDIIPMLFMKAFTDTTGCRLGSSDVGDILPDNIRLTLKKLTKTFMNRECLFKTPRLIRLFHDTSQKIVKSLNNCTTPWLETLKSSVKKGETPWFFLLDLLSSWLADLAKNRPEEAKLIGHHGTDLIKQCIFAGRTCSPLKDFSHFFYNSYGNCYTYNLHIDHFKVQDSLSGFTGPKFGLEIVLNLETEQYMPTSRESGAKIVIHDSTARADPDQDSVHVAPGLVTYIGVRMVNITRLPHPYPDKCSNVWRDLGLEKWARELNYDAYSTQICLKLCLQRFTIIYCGCWLPSSPPPKQDVPQCNNRKQKEDERCTEEIHQMYYNETINCDCPPRCTELSFEKFVSTGQELQQCSILTTANFGNKNNPNDNSNSDSNNNNNNKAVEIVIDKDDDSNDEDAEMKLDKNNMAKVVIYFQSLSYQEITQYPKYTVTTLLGAIGGILGVYMGFSFLALFEVFDLFGRVFCCIVPTPPPTTTQERIKSANLEQLSSSSSSSPEYSIKSQSNESLVKTMKSMNVKSRMVSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTE9</accession>
    <name>A0A922HTE9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein 63, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MRPL57</name>
        <name evidence="2" type="ORF">DERF_012848</name>
        <name evidence="1" type="ORF">HUG17_8589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTE9"/>
    <dbReference type="OrthoDB" id="6019958at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016576">
        <property type="entry name" value="Ribosomal_mL63"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14978">
        <property type="entry name" value="MRP-63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7637485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9502049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="117" mass="13961" checksum="E6F58ED9E0EBCE35" modified="2023-02-22" version="1">MKLSLILRSFRREFIGPIPKHKGNVLIGRKRFVPPVTLGKKIGLVQHLAYEEEVMKYLSKPYVNETQECRYLESKNMERPPYWDDFTRMTIEQPLQQSYSADYLEKLNCSRTFEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTS0</accession>
    <name>A0A922HTS0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">A-kinase anchor protein 10, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AKAP10</name>
        <name evidence="3" type="ORF">DERF_012589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTS0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="242"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="335"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="570" mass="66029" checksum="6583670996368186" modified="2023-02-22" version="1">MPLPNLIKNFIANSRDKLNQLSSNGSNKSIDSPSSSSSSYKGRYSSSQNGNFITSNNNDLSSSHQTSAKQTLSQISGLHSHRNLKPSYQMLLAESMYDPNVTVRLDSCLTCTFDECFTVEQNADILLCFVQFMESLGSHANTVIKCFLQTNCLMFFIQEKFPGDNENSSFENQEEHENNYQNFITDFHRIFNQLFDKNDASNCDVADAAHSTTTSMKIDPNVHSKMIELFDHHHNNDQIIPNYQKQQLSFEIFESFRQSLAEKIDCDYYEKFLRSNFFLKYEYEVLNGKKFQLSDILFSHTLISSAFMDFMATERMKCFYNIEIIENFSGQYSDANALYNRFFNCRAATIESFLQVSEPIIEQLQSSIVNIKDPKTEFQSDCFDRIANILLQYFSKTYFPQFLESNHFLEYVQNCDQKLKCSQNQKQKLIRPSMKILSKQSSSSSSTTSNDIGNHKLNSLNIDQTDLLWNRDLKDQLQFTYIDKYGRMNSTLEPEPPRSSPAVDRIKLAQIFRRLSFGNSTNRIESEDDAWRIAESIINDVCSVTNRQQQHQQQQQQQPEHPIEFDDFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU90</accession>
    <name>A0A922HU90_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU90"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="78" mass="8520" checksum="9E99AAFAD54089C7" modified="2023-02-22" version="1">MNGIHHSFTHRVVYSRKKNTIANGGGGSGGVGNLPKCKNTTKQTKCHQVESTTNNVSAMMQMTMSKCTQVTAKKKFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUG9</accession>
    <name>A0A922HUG9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUG9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="266" mass="29643" checksum="AC3EC123E9AAAD37" modified="2023-02-22" version="1">MNGCQFLLITDVDLFTGSFVSIVIAVVVVVDGDRDGDDVFVVDFSFDFLWVLLSSSLDPPTPPPPPPRPSQSDLERTFDCCFCACFVLFNNESNAVLCGRIDLDSCVCVVDKSSSNPSSKNRTDLRCRGDVVLDDNGNRSSLLSFEPSKSSRNERDDEPDADLGRDAIQKFLKDWLWFRILRCLVNFQFSIKSNNNAFNSRASYVTVFLPGCNVSNSNGASTMALTFWPYCSHIDKNCIHSCSTESLITITCLARFSNIARKQRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVY8</accession>
    <name>A0A922HVY8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVY8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="176" mass="20243" checksum="7585EE9E9EB5854F" modified="2023-02-22" version="1">MEISNLNFKNQIRDTLSMTGSIHFIVEKASLMLMIEEMLKAIPNDQKNLTTTNESPIKDLANENGNNKSKLIINVHDFSGNFLYLLINQLPNKDRYIIECFNPNTCTMLSIMKELDEHYANRIILTLVDRLRKAPFSSLRPSECDWEALVEIVILISNTLSSANQHQKNDRFVTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW34</accession>
    <name>A0A922HW34_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW34"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7359" checksum="0D783A343B3886DA" modified="2023-02-22" version="1">MTMTTTVSVSNIESKILDCTGPDEELSIQFISMAESNRNDRLFSCFMHSRKINLKPNDDADDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWB9</accession>
    <name>A0A922HWB9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWB9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7521" checksum="66FE2204DB498BD0" modified="2023-02-22" version="1">MILFYIEKQQQKLPHLVSFRIHNLPDFRNGSSSSSSSSCPIGIKINEPKLNYRLLYRSVVVAVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXC0</accession>
    <name>A0A922HXC0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXC0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="8672" checksum="9AC9021917683792" modified="2023-02-22" version="1" fragment="single">SSLFVKNRILDKFSRQTEYICVYIQIISVPKVITIVSDDCNHVTNQHHNHIYSDDCHLIVFKNIHVCKEFHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I043</accession>
    <name>A0A922I043_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_007769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I043"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="98" mass="11164" checksum="0B3B6CA6C6BB0F36" modified="2023-02-22" version="1">MPSKKSATPIIKLIQPNNKQTSIFASIHKNKTKYRISDISLSQQRPRPPQLSTPNKLKRPIMNDSNSEKKSTFHFIIIMIIIAFGFSFEEKSLECMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0L6</accession>
    <name>A0A922I0L6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier triple repeat protein 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_007086</name>
        <name evidence="13" type="ORF">HUG17_1556</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0L6"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052465">
        <property type="entry name" value="Mito_NAD+_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46131:SF1">
        <property type="entry name" value="SD08549P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="44"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="134"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="231"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7646018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9516338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="333" mass="38232" checksum="02C5E9956B822074" modified="2023-02-22" version="1">MNILNYKNDHQESHHPHNSTNTTTNIAITGNSVTQIDHHPIIDSCQLSDYLCGFGAAIVNVYATFPINKLIFRQMLHGQSVRKATATLRSEGIGRLYRGIAPPLIQRSITLSIMFGTFGTYHSLLDHYADQIMPSYARFCLSAFLAGSTEAIMCPLERVQMLLQDDRLHNRYANTVDAFKKLHIHGIKEYYRGLTAIILRNGPSNILFFTFRNKIKNHLPQNMGHHESYMTEMIKDFISGSIVGALISTLFYPLNVVRTRMQTQSPGAKHLNIFEAAIDIYNQRDRNLRRIFRGVHINYSRSFLSWGIVNACYELFHKLFFLTNQHNDDHNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1H2</accession>
    <name>A0A922I1H2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1H2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9518103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6860" checksum="B7E117EABC9F30CB" modified="2023-02-22" version="1">MGKSSGRYFILCEKNNINIIYRFYDKHSKCPVSISISYFVLLQPDQSQYTISIYVQSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2E5</accession>
    <name>A0A922I2E5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Cell cycle control protein 50A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TMEM30A_3</name>
        <name evidence="9" type="ORF">DERF_007962</name>
        <name evidence="8" type="ORF">HUG17_2252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2E5"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7646714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9517283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="424" mass="50591" checksum="07298E017F86D109" modified="2023-02-22" version="1">MLPTNEIVLKNNPLKRFWNEIREFLIIKDYKQQQLPACRPLITFHSVFATFLITSISLLTIGIGFMCISYYGDQIFRIDYTDCIPLSGSRSCSQILTDWRNRFDGRWPPPECICWYKFNLPESLHSNVYVYYALKNYYQNHLHYTRSKDFSQFHGYPSLHSDCEPFRYKLVRSINNNKNGTYGNWEYRGIVPCGTRANSLFNDTYTLWFMDHGNRTIRTVPLSRTNIAWPVDRAITNAIDYDVFRNFTNPPYWGNKTILDLDPMNPDNNGLQNEALIVWMRVAAFPDFRKLYARIIHRPRSTFARSLPSGPYYLKIDYNYPVKEFRGRKIFMLANTNKYIGGPYAFLSIIYLVVGCVCFVWTCILFAFQRRFGKSDRELSRIDVRTPYLYDSEYESQRKYQRQKIKRQHQYKRQQPNFELNYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I402</accession>
    <name>A0A922I402_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_005700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1142"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1228"/>
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        </location>
    </feature>
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            <begin position="76"/>
            <end position="103"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <begin position="148"/>
            <end position="162"/>
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            <begin position="1248"/>
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            <begin position="1339"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9522097.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1404" mass="152521" checksum="A552ADFBAD34496D" modified="2023-02-22" version="1">MVLDKTSAANLKKIIHNGIERTRKQRIFGLIDEIVNCLPFKHEFMNKSKREKLERIHSYIIDLKNKNDALMFANPNSVLVQEIQQLRERIDNFELMIISYQNLLKSAGISPDKLLIDPTIPETWKKRPLKYSSKYMTTSSKHIHNEDIISDDDDDDDDEEENGQNNQTVNRTKNSKTINRNIESRNQHSNIILTAANLSSASSLISTTFNLSGLNRSNSSSTTATTQQQQQFVLVSSGGPSGGLQAVPICNITPAIANLTNRTAHLHQPINHENISETKRSSKRSRSLDNNNTNVEKNQKTHNVNSNSLSNKSSKSLKVVKNSSKNKDQTTSAMIQSKSKVTATKKSKKKPTATSNNVKGSASKTTSSTRSKTKKKLTTIIVEAPFKQLSSDENGIHNENENDVIIMEQMNVNDTDSCVKESIQNDGADSKLDNAQTNEQIEAKNLNPSTLVHKNSDITDSSNIIDESVTKNNSNSLEQQNDEDQETLDLQNPQSENNNDNSKQQQPQRFSENVNLAETVTNKTNSTSSSYYTANLLMQTDPKISSNNGHADKNAEHSGSLFRFGTKSSEQDGQQQQQQKRAILSSSTSGYHSGNHQFEFDYHSLYHSADIQTTTVDNVSQSQLQTTTNHGKSSNSFEMSTFVSSTNSPSTSSAYNTYQCPSSTMTSNQNSQFNNLIDFQPSTFTQSNDHIVGSNCILQEIGQSNNNSVTRSTSRSNNSKSSNLSTATNQRNNNKKSQTPSTTKNISHSRSNGTSKTLVSSSSSSSSSSSSSINTSKTSKTITTDVASTSSPNKRNSNENYFLIPDIISTTSSLSSSTTTSNNHNLNHQQPVNSYNSNNVTAEQSSSSSSSYNHNSNIRYPNFFVSSSSHQSNSDQQQQQQQCLINSESTQEESSNSASQELISSCYPILFRPHHHHSNSGSTTTTNSTSLPSSYPRSSATSSSYSTATVSHQSSSQQLNQSQSQHQQQHQPSQHSSNQLQQSQSNSNTSLYYPVTSSTSGSLSCSNHIPNFNLSNIFPDITSPSTSSSLAPLPPSPAASIVNSSAYPSYIPSSIPTADPSSSSSVGLVNGGGGSKFNSRLSSSSISNNLPKFLPGSSSSSSSITKSLTSSSSVVSVEALTFSSSNIGSSSVTGSLVESTHQTSKNYYQPSSHSNSSNYQSHFYPPPPPSASTGPHSNFSNATNVTPMSPSIITNRRPSTSSSTAVAIAAINDTTSNATATMMNHHRNYHHLVPPPPPSTAAVDNHSHHTHQSHHHPHPSFGPFPYPPPPSMVHHHHHHHPHHTHQIDPSSSSSSSNVTFGQHSVQSQSHPSQRSNHSHHTTMGVVHGQSATHNPHVPSSSSSSMMASASSTTSTLTSFRSSTSSSSSNVDNNTSSSSSSVPPPPPHHHPHISFPLFNIHRSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I434</accession>
    <name>A0A922I434_DERFA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I434"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="78" mass="8457" checksum="4D5BD2E682029B8E" modified="2023-02-22" version="1">MLVITRPSSVSFSLTAEWTSCRNKDGANGDKTRSPFGRIIRKSCISDTAVPSESDHQTRIGCIPVTLHGITAPVSLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4X7</accession>
    <name>A0A922I4X7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_004503</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <location evidence="2">Sarcolemma</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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        <name evidence="1" type="ORF">DERF_008242</name>
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        <name type="common">American house dust mite</name>
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            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
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        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
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    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="component" value="Unassembled WGS sequence"/>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I631"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7562" checksum="16ECE5503B5E1523" modified="2023-02-22" version="1">MIIAIVFSSLFSSRHITLNPIEIYPIHIQALLWLSSSAYINILIDTHYWLLYIELLYLDDNHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6D3</accession>
    <name>A0A922I6D3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease</fullName>
            <ecNumber evidence="10">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_004558</name>
        <name evidence="13" type="ORF">HUG17_0626</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="10"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6D3"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="12">
        <location>
            <begin position="99"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="11">
        <location>
            <begin position="100"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7645088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9520874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="319" mass="36814" checksum="11E84A20D489A53B" modified="2023-02-22" version="1">MNTSGKLFINNRRLWSWMRASVLSIGAFSIGVYYERKCHLYADVVAPGPTTTTTTLNIGTHGDDVIDSPKPSLHGSGSSNNHMAQISRFGFPSMDSLRSYRNFLLSYDRRNRIANWVLEYVTNDDLNADDYNRKGIEFREDQSFHRYFRSTNQDYKGSGYDRGHLAAAGNYRNNPEHIKETYVLSNIAPQIGRGFNRDKWNDLEKYCRRKIRELKSSSGLWICTGPLYLPQKDAVSGKKFIHYEVIGHNHVSVPTHFFKVLLYPGHNGQWFMECFLMPNQIINDKTSIHSYRVDPEIIERSAGILLFNQIPRHQLLINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6I1</accession>
    <name>A0A922I6I1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6I1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7780" checksum="4FD729EFFECBB2B4" modified="2023-02-22" version="1">MNQMVVGNRCVPICRWLDEYHIPIYYKHSINDDNLFRLIVDWLVTVTDVDIIAVETAAKRWTSDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6Z8</accession>
    <name>A0A922I6Z8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000642</name>
        <name evidence="1" type="ORF">HUG17_8405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6Z8"/>
    <dbReference type="OrthoDB" id="10592772at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7640936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="279" mass="32734" checksum="8CDF960DFEADE47F" modified="2023-02-22" version="1">MPRITFPFKIHRSRSYTLNDDCQKNSCKHHQNVLRIGGEYVPVFEILNFGSVSDKELLYIRIAKQGLIISHKPSVNLSSLAGSLDRPKSEMRNYHVLPAASNHHHLYLQRYNTLRGPCHRTRSDRCRLIKWDQISGIQILKPKSLIFKLNRLEDNNIVDDCDTDVVDELRLYRFCSHRNENISLASLLHDYRSKINDNDDDELLRFEFLIKQDLEAMIAFGIHHQLLQPDDDGHCGVRTFDHIKNTNNTNNKNGKIFSRLFRWINRHMIVTFRSSTKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I765</accession>
    <name>A0A922I765_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I765"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="98" mass="11208" checksum="4589EE1821E7CCBD" modified="2023-02-22" version="1">MEEVVTVPEEIFNICVSSLKCENRFPRFFFYIATSNYITYMAAIYVSVLLRFVHDDDDDMSHITVESWNSVLIYKSITLLNGECRASATAKKSAPNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7Y9</accession>
    <name>A0A922I7Y9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_006541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7Y9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038:SF3">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 20 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="76"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9522988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="518" mass="60362" checksum="F6849BA4AB5587B4" modified="2023-02-22" version="1">MFAKMRRTMKYELNHLNGDHPNLNHDDENVNDDKMMIKDSSSITLDNCNGHNNHNNHQNKTILSSTQLPPTSQLPLLVESVAFNYKRNVPLLKDVTIHVPKGVLIFVLYRMYIFITRFKWLWQNNIIKYILLGRIRPDRGNVRIFDRQPGSSLNHQIGYIPQELGLNPLLHIEDTFYYYAQVNHVNDRQFIQEQIRIYLEMLELEDPKPRVGQLNGGQKRLLSLDEPTVGIDSLIRSKIWTHLRQLCLLNETTVIITTHYIDEAKNSDLVGFLREGQLLAEESPELLMQALESATIFQQSRNNQKDDSLNNNDDTFPDQYNDNNGKDDDDDDDGDKNLKRKHTNGVILQPEMLKNNNFCSSFNDKQEKIFTCANQFINFDHINALIYGRTPQIVPIAIYNGDESDFNPHLSDIFLQEFNTSMVKMTFYDNELDAEHLVQMGHNVMAIVFRSNFSTNIVTFYYDFHSFVDQKKDYLMTTYAMINIATNSMPSNFAFQDESFIGEINIWKLSCLEFIRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8J8</accession>
    <name>A0A922I8J8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Duf778 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_000438</name>
        <name evidence="3" type="ORF">HUG17_8244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8J8"/>
    <dbReference type="OrthoDB" id="267284at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008496">
        <property type="entry name" value="TMEM222/RTE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20921:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05608">
        <property type="entry name" value="RTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7640775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9526340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="206" mass="24197" checksum="5B6C4AE88B5C1F47" modified="2023-02-22" version="1">MVDNDNLDTMLRRENNKNNGTDISVDDEQKFAAKYKIDHKRRYYPFTIVWTPVPIISWLFPHAGHLGIGKSDGSVKDFGRPYKILTDSLQFGRPLKYWILDPRLAKNGIKGWDDGIDDAGNVFCKRMNYVLVSNCHSHVSTALNHMQYNGRNDYNEHKLFWLFNKNCHYVSKWTFIRTWLPLTLIVSIITIIVLYFRTNVFDDLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8L5</accession>
    <name>A0A922I8L5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8L5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="47"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="174"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="444" mass="50614" checksum="ECF2997046CD98F9" modified="2023-02-22" version="1">MAILSESVPNGKIIEHLNAEQMDRLFMEKFGSRINSNGEIRLPDPSVAGVYEVQVLMPSNESILYSVDLRRGRLVRGKPPSEDCDCRVQISAYDLLSMLNGQLDFAQGFLQRKLRIARGNQASAFKFLHLLIDIASSTSTEDSSKNLKSNENDKISIVPTDGLKSDVIFTIIQRRLSSEPELVKQMPFIIEINLTQNGRPIATWTLDTKTEGGRIYRYQSKNDDSTNTNNRIKPDAAITIDDNDLVAIMLGNMNPQRVFISGRMKIRGNIMLLQRLNQFWTKIQNTRRGPDFPFVKKLLTDNKFETGLGSEMVFFDWIARLVRPPFQLADCTIHLIITAKREKQIEWVILYDSNNQLSSIQRRRIVGVENYGNHNDHSRSITLEMDDQEFCRLVHSSDQNLMQAIDQRRVHVTGDDQLLSDVSKLFDQIADNDQTPVVSLKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9G7</accession>
    <name>A0A922I9G7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">1-phosphatidylinositol-5-phosphate 4-kinase</fullName>
            <ecNumber evidence="11">2.7.1.149</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_005464</name>
        <name evidence="15" type="ORF">HUG17_3535</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
            <dbReference type="ChEBI" id="CHEBI:84968"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:55993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:83423"/>
            <dbReference type="ChEBI" id="CHEBI:84968"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:55965"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12280"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57795"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.149"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:12281"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.149" evidence="11"/>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9G7"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016309">
        <property type="term" value="F:1-phosphatidylinositol-5-phosphate 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17305">
        <property type="entry name" value="PIPKc_PIP5KII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 5-phosphate 4-kinase type-2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="14">
        <location>
            <begin position="30"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="300"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7639502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9521838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="428" mass="49685" checksum="126D420BD7653E2C" modified="2023-02-22" version="1">MSSNHSTTKPMKVKTKRFKPKHQKAKLFRASEPLFSVFMWGINHTINELTHVNTPVMLMPDDFKAYTKVKIDNHCFNKENMPSHFKVKEYCPLVFQNLRERFHIDDVDYMNSLTKHQPREHLVSGKTSTKFYESYDRLFLLKILTSEEVESMHHLLKEYHPYIVERHGKTLLPQYLGMYRITVDGTETYICVMRNICSSQFINVHRIYDLKGSTVDREASEKDKTLDVPIYKDNDFTRDGVRIYAEEEWKKKFFEMLEADTTFLMKKNIMDYSLCVAIHDCERAEQEAQQRHAEGLNSQFSAEDEEAETSGDNCCQDQAPNSMLSPPDSPESQSQPKMSADSDNVLLYSSENAIDSSRDIYAVIATKDSPRREIYFIGIVDILTQFGIRKRTALAAKTVKHGTTAEISTVHPEQYAKRFCEFITKVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9Q3</accession>
    <name>A0A922I9Q3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9Q3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="248" mass="28145" checksum="8DD743D5CE1FECFB" modified="2023-02-22" version="1">MVTLVKTPTIFIIIQQQQPSPNDDLTDDDNTGSNVHGFSLYVSIQSMAHLFAKHKDMFADLDGKMCAQYNNNDQNCWNGTNMVSSYQARQQDRQQHQSLSMNSGHHRNHNQNVSDNDMIITLHDRVKKSETTIKELLIHNQRSSKFINSQSTANDDHQLLIDRNDNHFDDDDDDDDLNGHDGSGDSSGMNPIMPDDEDYNYQDGSGHLPRLSINHDQQPNNMDDDDDDDSTTNTGDIMIDPITKKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBA9</accession>
    <name>A0A922IBA9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBA9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7987" checksum="28E913DA17D8A1ED" modified="2023-02-22" version="1">MNHFIIIIVHSFIQTPEKNDNNNNNHHQQQRQRQQKQQRVVVIVESKYTRINFGSNPNRFLSGIMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBE8</accession>
    <name>A0A922IBE8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBE8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="32" mass="3544" checksum="F06825DAFFE3CC8E" modified="2023-02-22" version="1">MLEEILVSITSVPPLQSSVTKIPFIPISIIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBF8</accession>
    <name>A0A922IBF8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">General transcription factor IIH subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GTF2H4</name>
        <name evidence="13" type="ORF">DERF_001231</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBF8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="12">
        <location>
            <begin position="411"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9527196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="485" mass="56459" checksum="F694C675D948EF69" modified="2023-02-22" version="1">MTNVSSINKPSTSGEQNSSQEFDEMNIDLLSYLEKFNPILLNQLYECPTACLAVFRELPSLAQNFVLRLVFIEQPIPQAVVSSWVKSISDYNEAADVLTRLQIWKSTPMQSGLPGRLLNTTFQKSLQTSWLGGGKQRSIFNSLGVDKHRPDIETLDNYSINKRWDSILNFMAGVKLKDYNDNIGEITKKVIFNAGLIETDDNGEIVITASGFQFLLIDISLQIWYFIRKYLELVESFGFNYIECLSFLFELNFLTHGKSYSTDGLSESIQSFLQHLREMGLVYQRKRKDGRFYPTRLMIRLFESVRRNFHLSNMALTQQYNKRQGFIVVETNYRVYAYTESPLQIALLTLFIELNYRFPKFMVGLITRDSVRTAFKNGITAKQITHYLSMHAHPHMYSEKRSTVIPGTIIDQIFLWEQERNRLTYCDGVLYSQFNSQTDYEALRKYAFNLGVILFENSSRRLLVVTPTGHEEVKRFWKKHKKERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDC8</accession>
    <name>A0A922IDC8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal-induced proliferation-associated 1-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SIPA1L2_2</name>
        <name evidence="3" type="ORF">DERF_000666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDC8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="214" mass="23532" checksum="66D48C15BDDD7BBC" modified="2023-02-22" version="1">MMSQSYDCNNLYQSLLTGSIHSAGGDTIGDIVWPSMHSSLVDHQSSYITNNHHQQQQQQQQQICASTIANNNTDSSSITTNCDTNSSSNTSTSGQVRHQVVAAQHLTEEVRKLSLEKDVLNDTISKLREENQRLHLESQTASQQLRKLTEWFFNSNPNASTTTTTTTSSSTTVCEPSSSTNTNTITISIPQQQQPTTTSTSIPMTTTTTEQTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDP8</accession>
    <name>A0A922IDP8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
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            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDP8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="93" mass="11006" checksum="E31380069DA3EA63" modified="2023-02-22" version="1">MYFDNINNIQFFTLKKKSQLNDDDGDGGGGGGGEWRQQKMERLWQDRLHQCEIENYNVLGPCILTDADIRFLYIFYLMCLYYLIYAAHLEPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <gene>
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    <organism evidence="1 2">
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9530197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="7023" checksum="CFBC4566B969DDED" modified="2023-02-22" version="1">MNQNDNDDDDDIEKWAKERDHTILSIQSLYLHIFKLSNAMNVMIHFPSILNRPPPLTTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A922IDW9_DERFA</name>
    <protein>
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    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
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            <taxon>Analgoidea</taxon>
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        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9528576.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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    </evidence>
    <sequence length="344" mass="36362" checksum="2DE4D2AFFB105260" modified="2023-02-22" version="1">MIILFPMAVVMIILASVLDTIVCLPISSQNNDSNGSFEMFSNSLSKRIENLSVNKTNTTNELPLLPLPPTNVSRLEMTPDVNHALTIDHQNIVINLGQSLSSGITNAIVRPLTFFNNLIGSAAGSLPGLFAANGAALGTAIATPIQLGTLAANAAISGITGTVVSIPISLASGGAAQLVGLIGTGRQLWHSTLGSDPNNSTFWQNGQLWLQPLAVVTGTNSILAGVGLNALSQGVKNLGWSIERFGVSLSNTGKNAKQFGSVLIGWANGKPFPMDTITKIDLDKMIPLNLESESMIETTTTTMVEIENSQTQSKNADDDDDQIAENSIHNEKTTNEITNQPKEM</sequence>
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<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">HUG17_5043</name>
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    <organism evidence="3 4">
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            <taxon>Astigmata</taxon>
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            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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            <taxon>Dermatophagoides</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A922IDZ8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="267"/>
            <end position="378"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9529108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="389" mass="46173" checksum="7C8A232A6652975E" modified="2023-02-22" version="1">MMTIQKQRSEHLFQSLEQKRLDRSFTIRLPRFMDIGKYITCNYFYETAARFSSDERRRSFYKSLRIGDKFIAKVMHIYNRNAEVLLVWSYKRDIHDLRLKANLRLEPHLRTSKSNRNFNNDNDDQNIERSELINVELIDFEHISYHLDVIRCGPNEKYGHSEDLDEIDETAIRHGRYRTIGPDQQSFYDYMMDHNDLRNPSLVKLHPFTSMKNFDHVINCLEYRNEIKAQKLRINYESTIIAHTSKAKITPSDIEQTPKTVSDIVKLNFPESSSQKRSRSSSTTSTSSDSESSSSLSSHGHHRHRRYKSKDGNVSNHKQTKNKKRHHHKTKKSRHNRISDSSSETESRKSHKRKKRKKKKTSKYSKHRSRTNNNDNRIDDKILQLLKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEA6</accession>
    <name>A0A922IEA6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Otopetrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OTOP3</name>
        <name evidence="13" type="ORF">DERF_003194</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEA6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF62">
        <property type="entry name" value="OTOPETRIN-LIKE A, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="690"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="760"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9529303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="879" mass="99619" checksum="46074BD53D075B08" modified="2023-02-22" version="1">MFENWCRSCTGESLEISQEMPEQNGGDSTLIDNDTDVATAMMLHSQQSTNDDSIIVEFNNEKFDSNNHGMTKKKKSAKTTKNDNLQIKMKQAKIGQEKKQYASVCRYRNLPDKCRRPYFMCLSVVKYETNFRLNMSSSKLFSSNRKNESNTNNNRNHRIERSSASSETSLISSITNCSSDNLGYHNRIYNDNNQRHSNGHHHHHHYQLSHDQNPNEIHHLPHHNHHRHQHHCQHHHHDTNPNHVHHDNNNGTRINNKIDMMLTRSISSLMLSQSASKNSVYLPKNSKTAAFIVTSSIYGQLLVVVCIALFTAKIVAPVLPLWYFEQYVVALCSSPSSSTTISSSLKNMHSTYICTRLAYCSCFMFISTCSMMFLNWILFVRILFSYIRNYEGKNHKIGETDRSHASIFLRIGSIIFGLGVMIYNGLEFGAYFEISPDSPCHSILLGVNPILQAAFTFSQMYFIFTYSRLMINKFKLIARIGLMHLVATNICVWIRTLGKEALHELKSNSSNLSLPESSSSSSFSNDFTTKTKSNVMSTSIGNITVNHFSHTINSTYFQCQNENVMGSILLNASPYLYPFIVEYSLIAAAFLYIMWSSIGKKFMLSYETDTTNSSTSCHHHNHQMQIDDLSSSSRTSSYQNLSALYSCLGSSKGLFTGFLFLAISVTSLIIFFVLVHHPNYNLMASLLSDISHSILLILSSFAILIGFFKMRNLKFLPAMRDTADGGLRDLLLRIAAFGLYAYSLFGVIASSFELNSLQHITVLVTSVLTIIQVTLQTLFISDVVCRKRTGQKQSGRQLITFLLITNLTLWIVYTFVMQKLEASPIQLKVFGFTTWALILRITLPLSIFYRFHSAITFAEVWKNSYKTSTSSSVSSSSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEE7</accession>
    <name>A0A922IEE7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEE7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="87" mass="10131" checksum="80B1FE8477D1C096" modified="2023-02-22" version="1">MIGNVCPDLTSRIRSNHNLHSFFSGCLFRPASRRKNKSCIHTMIDLTEIIDQNFFFFDFSFKQPLAITILTIIECKQHVNTQQEDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEN0</accession>
    <name>A0A922IEN0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein ZIC 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ZIC2_1</name>
        <name evidence="13" type="ORF">DERF_003683</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEN0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000035">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000039">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000041">
        <property type="entry name" value="Zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000050">
        <property type="entry name" value="zinc finger protein ZIC 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041643">
        <property type="entry name" value="Znf_ZIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18366">
        <property type="entry name" value="zf_ZIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="380"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="449"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="385"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="488"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9529820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="527" mass="57458" checksum="EF269821544D3409" modified="2023-02-22" version="1">MIFSSPSTQNSTTTTTTFDEQHSHGMDDLLQQHQQQQQQTSSSESSSTITKTTTTSTPSIVSAATVTSMYHRAAAAAAAAAAAAASVNVGGGGGGGDHHHHHHSHHQHLNHLNTNYSSSHHPHHIAHPPHHHQTIDFNNTTATATTVVGSAMAAAAAAHAVNHHYGHLTAMNPIHHQSAALFRYMCHNNNNNNNNNSSSTSSSPTTMTTIINNNTNNNNNKQELICLWIDPDQLLKKPCNKTFHSMHEIVSHISIEHVGGPECSNHTCFWIDCPRNGRPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFKCEYDGCERRFANSSDRKKHSHVHTSDKPYNCKIKGCDKSYTHPSSLRKHMKVHDNNNNKPQSLSSSSSSMSPMSPTSSLNNNHNNHMSIDNNNLARNNNNIDQLSSSIAMMGGGGGNDHHIIANASSPPINNNSNSSTASHNYQQQQSQHHNHNRLLTTATSTTNSYLSASSSSSSPHHHQAATTTTTTTSHESSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IET1</accession>
    <name>A0A922IET1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IET1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="383" mass="43674" checksum="45B680C80455D4C3" modified="2023-02-22" version="1">MDYRPHVHYIIDKSTRIFRQILGMARSKYGLGCKVIRQLVQSIIAPILMMISAGFKRPIAQLACKSYRTAAFISTTAITDIMPFNLQIIERAYINLAKIRRRYWINNEQAVPVDTPDESEIDPGPGPMILTGDATVVPEYHVFTKSTLTNRGIGCCVFILGGQTIIDTLVFRMPTYCSLLQADHFCVLKAIEWIIENWPYQHSVYVINNNLGALAHLMKKDKNNLANMAKDIIRTNCKRVAKRAANSNRPFDYSMAPMATVKKKEHCDILAEWDKMYRLNKFGTTIKQICSTVGEARKFAPYANFWLSQTLTGHGQFGAHLKRFGFINDPSCPCGNPNQSVVHMINDCRLANRLRADFNDAKRRATNHDERTRITATFFEQWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG19</accession>
    <name>A0A922IG19_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG19"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="6795" checksum="4029E5F262802188" modified="2023-02-22" version="1">MASCSNDPCLKTVVTSPSSSKRKFENILAQDGKFKYSDSGRLQPTVHMKGLSVAYQEEMIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGK0</accession>
    <name>A0A922IGK0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GOT2_2</name>
        <name evidence="10" type="ORF">DERF_002628</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGK0"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="62"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9528708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="434" mass="48527" checksum="C6E10F56BE36AF2D" modified="2023-02-22" version="1">MFSSPIRCLIHPSTILSPCHQLSPSTLHLCRRSNSWWSHVEMGPPDAILGITEAYKRDTNPKKVNLGVGAYRNDLGKPHVLPSVIKAEEKLSELNLDKEYLPISGLPDFTASAAKLAFGDKSPVITEKLNATVQGISGTGSLTIGACFLRDFHQGPKDVYMPTPTWGNHIPLFKRANFNIKQYRYYDPKTCGFDFPGALQDIAKIPEKSVILLHACAHNPTGVDPKLDQWKEMSNLIKQRNLFPFFDMAYQGFATGDIDRDASALRLFIQDGHRVCLSQSFAKNMGLYGERIGAFTVVGSSQEEASRIMSQIKIIIRPMYSNPPLHGARIASMILNDSSLRTQWLKDVKEMAQRIIMMRAKLRNVIESEGSTRNWQHITEQIGMFCFTGMDKSQCERLTKEFSVYLTMDGRISVAGLSSSNVEWVGKGIHAVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KU48</accession>
    <name>A0A922KU48_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epoxide hydrolase</fullName>
            <ecNumber evidence="6">3.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EPHX1_3</name>
        <name evidence="9" type="ORF">DERF_014972</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol</text>
            <dbReference type="Rhea" id="RHEA:55764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:139161"/>
            <dbReference type="ChEBI" id="CHEBI:139164"/>
            <dbReference type="EC" id="3.3.2.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin</text>
            <dbReference type="Rhea" id="RHEA:23900"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:50004"/>
            <dbReference type="ChEBI" id="CHEBI:50014"/>
            <dbReference type="EC" id="3.3.2.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.9" evidence="6"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KU48"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="8">
        <location>
            <begin position="43"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9494278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="452" mass="51861" checksum="C27AB5BB64383521" modified="2023-02-22" version="1">MSKSSLRRLLLPHKIQLPPLTDGWYGRASLAKGEQPPPDDPTINRFNVNISAEELDDLKKKLKSARYFEAIEGTNFRYGFSAETLTQIVDYWLNKYDWRRWENELNKYDQFKTQIEGLDIHYVHIRPKNPNGVVIPLLAIHGWPGSFFEYYKTIPILTDSSLEGLSFEVVIPSIPGYGFSEAPHKEGFSFISAARVFVKLMKRLGLNRFLVHGGDWGSMISKTIALMYPENVRGIHTTFYTSSQPQGADNFKYLMAKYLPFIMFNNRESQRTMFNDLLHYKSKWFYESGYFHLHSTKPETIGPALTDSPIGLAAYILEKFSAWTDPTNVFKPDGGLTEKFTMDELLTNVMIYWFSKNITSSMRFYKENGCPIIGVYHKYRIGAAKVSPTVPAGYAVFPKEMVRVPEFIVRMAFENLVHYTELPSGGHFGAFEEPKLLAEDLRKFAFTVVTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KV99</accession>
    <name>A0A922KV99_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small VCP/p97-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_014896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KV99"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031632">
        <property type="entry name" value="SVIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15811">
        <property type="entry name" value="SVIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9494186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9144" checksum="A25C233F1782D372" modified="2023-02-22" version="1">MGSLCCCGPRSSSSQSLDENSHLSVGNITEEERRRRAAEAAEKRLQQQQMRGVQSGTADSVPLRVAHSEIPGNMNSNLRWQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVF6</accession>
    <name>A0A922KVF6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVF6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038011981" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9494276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="16866" checksum="AB5042ADCA1E8082" modified="2023-02-22" version="1">MMMMMINVVITTILTPQIFWFQQQQQQNRDYHQDKFDKIHLFNFTHTSLYDDNYNQFILKKFIIVKQFYISSSCVFLPLIYVHIFIYKIDLREHMANCLLINYYYLFCTYDDLSSLMLQCIILKENVYIEVKSLDSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY13</accession>
    <name>A0A922KY13_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_016702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000010">
        <property type="protein sequence ID" value="KAH9490503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY13"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9490503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="143" mass="15226" checksum="E7192BBC7CAFEE52" modified="2023-02-22" version="1">MMNLNLNSVVALTQLAVPHLEKVKGAIVNISSILGQRPNQYFMPYCVAKAAVDMFSKSIAIELGPKGVRVNCVSPTAIRTNFQQASGAGEALEGVLKHLEETIPLRRIATVEDVTNAVLFLASDKSSFITGSNIVVDGGNSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY73</accession>
    <name>A0A922KY73_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY73"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038011454" evidence="2">
        <location>
            <begin position="27"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="795" mass="93159" checksum="45AC1403FAC8BEAB" modified="2023-02-22" version="1">MSLLWSAGSLVTWLANILNHHQLANAHYNQQQQQQQQQMQHQLQNHHRKQQQQQQSSKTFRKSNLSLQKKKVSCQSDSNDIIEPNRPSSSSSLRPETDPQQISNNYQLQQQKYENDSNITESLNNTVFMASTITDNDPEVSTSSSLQHQYDHELDINHDQETLLQRQFNLYRYYVSQYPELFQEYFRQLRQQQQQQQQQEQLQPKKELKLSEQQQQQQSIIVEQQFESPSSSMIKQNDNANQIQQSINQNHDQQQQKIRRDFFVNENVKEKTTTTTTNPCRLLCRCSKCCPTTTTTSDSSWSDQPYQQQRSQHQATSNTLYYLDANHLLEDERYEHLSRVITPPNAFLNNQKISMSNLNDNNNDMKNHQIEIIDGHGFSNYYTNSIDQQQQSLNTIFYSDKRTQTDAEELIQNGLLQTQTQQPQQQQQSSSTATTTELSYQKIDHLSRRLQRQLSLIDTKSAQQQQQLHHQLSEPLKNHYSQQQQQQQQSKQQQKQFDDDHIYYTIRDPNRFSNINDSNVIYSSSTTKQMNKMKNNNNKMILSDKSNIVMVGGQNNVGSGGGGKSFWNRLSHNRSEKQLNKLNVDHHHNGENGKKSEQQQPQQYQQKLKNYIQAMYLDQDKVPDNNNITSDELYQWSLIAGDDLDDDDIDVNKSSMMMVEQQQQQHRIATSKNGIPCACERCRESRGMNLTTELLPIDTQIPLQTMDNMDSFFQDSSMAELISTSKKIFRRRRYRIFKDLLLIDCFNEKKIETETENESKKLLNSPTTTTAKWNAIKLAGYQHHQRNWRQFVAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYA4</accession>
    <name>A0A922KYA4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYA4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="320" mass="37319" checksum="63DEAB8555B3C170" modified="2023-02-22" version="1" fragment="single">IIVEIYRRFVHEPKAIIMQSNTTIIYPACFLFRKWSLIIIISLDLMIIFYTTFALIGRLQILENNSNDITGNNYYSELYHNHHIHGSTLLIHKNLYDSDGNNNNDDDDDNKWINQTSLIMEMKPTVAASAINPFNLFPTLAFDIENPTTMMTTTTTTTISTETDTFDALTSNNDDDDDDDQIDYDRYHYHHEQFKNSNNDHTNSSISSESEHPIWFEMFEHRIYQRPKLLAQVMANFFAYIVCLIGLIGVLRENYFLTTIYAWFGCFSLASSIMIYVWTWAPELFGKIMSNLLFLILLFMYLRDLATIRLQITENIIIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYS6</accession>
    <name>A0A922KYS6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Microfibrillar-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MFAP1_1</name>
        <name evidence="6" type="ORF">DERF_013585</name>
        <name evidence="5" type="ORF">HUG17_1062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MFAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYS6"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="4">
        <location>
            <begin position="110"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="135"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="210"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7645524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9497608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="369" mass="44038" checksum="BD237EF3E46788FA" modified="2023-02-22" version="1">MRRLIKFREQSNKEGSRPTIKPQVIKSGQKSDQEESDPELEHDEDGDVIRRRHRHREVIDAEENDDENIERRHELLKQRMLKLKLEPAQNAFSDDDENDEEESENESKYSEDEVMPRLKPIFVSKKDSITINEKEEQERKRIETAELEAKIALEERRRSTLKLIKEDRRREEEEREKNKAAAEEEAIIKGIASVITDDEDDETAFELWKVRELRRIKREKEEEEQRDRERREIERLRNMTEEERQEELKKNPRVVTNQQKKGKYKFLQKYYHRGAFYLDAEDQVFKRDFAQPTLEDHFDKSVLPSVMQVKNFGLAGRTKYTHLTDVDTTAFDSAWSAKDNTHAIQFHQAHGGGMKQSFERPGKRKKMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYZ8</accession>
    <name>A0A922KYZ8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase subunit 6B1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase subunit VIb isoform 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COX6B1</name>
        <name evidence="7" type="ORF">DERF_011102</name>
        <name evidence="6" type="ORF">HUG17_5887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYZ8"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11387">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7643525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9506365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="96" mass="11392" checksum="CA31EB757DD2B21E" modified="2023-02-22" version="1">MNVVEIEIKGNEGVVKNPEMLKGRGQTVPYDPRFPNTNQTRNCYQNYLDFFRCQKVKGEDYEPCSWYKFAFHELCPPAWIEKWDEQRAKGIFPGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZD7</accession>
    <name>A0A922KZD7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glucose dehydrogenase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_014673</name>
        <name evidence="5" type="ORF">HUG17_6545</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7644183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZD7"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF227">
        <property type="entry name" value="GLUCOSE DEHYDROGENASE [FAD, QUINONE]-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7644183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9493949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="649" mass="73400" checksum="8E1F3D2EF16BD4E5" modified="2023-02-22" version="1">MLTSILKLNAAIPALLPVFMFMYVHRMRHETPFVREEFLREYDYIVVGAGSAGPVVANRLSENPRMKVLLLEAGGHEIYQTEIPVLAARLQLSEFDWQYKTEPQKYACQGMIENRSNWPRGKILGGCSSINYMLYIRGNIKDYDLWEQWGNYGWGWKDVFYYFIKSEDNRDPAILKNGYHGFNGPLTVSTPHYTTAIGGAFLEAGKNYGFPNIDVNGPRQTGFAIPQGTVRRGARCSTSKAFIRDFRERENFHTVIYAHVTRILFNEHKRAIAVKFDRKGLDYIVYARREIILSAGAINSPQLLMLSGIGPRWDLEQLGIPVISDLPGVGENLQDHIGVGGMQFHIDAPVSVVQPRMYVAKSFTQWIALGIGPLTMLGGLDGLGFISTKYANASDDWPDVELHFIPSCPSSDGGESVRKAMNLKNELFQKIYEPFLYDDSFAYYPVLLRPRSVGWMKLRSANPYDQPIIQPNYFKDPYDVKVLVDSLKLSLKMALSKPFQKFNVRPWSRKWYGCEKYRWFSDEYFECLTRSYSATIYHPVGTAKMGPPDDPMAVVDPQLRVYGVKGLRVIDGSIMPKIVSGNTNAPIIMIGEKGADLIKGHLYPPVNVRPGYAPIPEYLKNPETEKNAVGGPLSKIGHLFGKFNFLKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZW6</accession>
    <name>A0A922KZW6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_015059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZW6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14535" checksum="732E0932BB4F78E2" modified="2023-02-22" version="1">MNKSVSILHRTPMIYKNVKPFENLHIDLWEAPVPSVQGCKYGMLIVDHYSRFTFGIHIVSKSDAVSSLIKFIEFHHKKFKRKIKSIRADQPRSKRLKFDKTVLYKNPVHEISHSNSVNLRSFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0M3</accession>
    <name>A0A922L0M3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0M3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8482" checksum="9E55C9789BAC1EF9" modified="2023-02-22" version="1">MSFTNEFMIDMAFDEIPIEKDSLRRRCFFFLSVARTDFCALPDFLTALPVLGGAIVADSLWKFKLLIAKTKQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L187</accession>
    <name>A0A922L187_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L187"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="150" mass="15588" checksum="0CEEC709F8240FAF" modified="2023-02-22" version="1">MLSTFSGYFIHNLTMITKFRLFWSITTLLINDGNKSAFDDVVDLLILKKGIHGNNIRSCDVDGCGCVGDSCGGDGCGCARGGYGDGEDCGDGVADGKDGFCVATDFAELKLDNDDESSSMFSVTMLALSSSTSAASATFRPSSISTSAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1U2</accession>
    <name>A0A922L1U2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanine nucleotide-binding protein-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GNL1</name>
        <name evidence="8" type="ORF">DERF_009735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Possible regulatory or functional link with the histocompatibility cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1U2"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF3">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="232"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9511267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="672" mass="76755" checksum="B7BD8A90CE390DB1" modified="2023-02-22" version="1">MPQGRRKVPFSNKQKKAQLQAKREKKNRQLTTTQLRRPFVSDDGDIEDELDDETFGGTIDVNDHFSPNQSSGTSNNNNNNNNNNVESNTSTSNDNMTDPKFLLNRINAINTQRHLSTTSDVNRYALQFFNETDQEIRERKERAQRPLPPLDESKALVCSVEDMFGEQSSLSNDIPVTDLDMPKRPPWSSTMTVDELYRKENEYFLSYLTEIFSKSRTLDKPISYFDMNLETWRQLWRVIEMSDIILLVADIRHPIFHFPPSLYHYVVDELGKDMILVLNKIDLVDAELVLAWHEYLKNRFPRLNILEFASYAGMKVRASSGKRVGKLRMAVRGALALQEMVAKIVGDQADLNSWRRKIESELHECENVSLDDDSSYYESEDDDDDGKHYGKKNQGAKKAGVEKLAGTIVMEKADSSYYRQDQRFKDGIVTIGCVGHPNVGKSSLMNALYGKKVVSVSRTPGHTKHFQTIFLTDKVRLCDCPGLVFPSRAPKELQVLMGCYPISQLREPYTAVGYMAQRINLVRLLRLQHPDGDTENIWSAYDICEGWAEKRGFRTARTNRPDIYRAANSLLRIALDGRTICLAFQPAIYQEHGKDYWSLHQDKEKIEAIQNLKFVVEEQYNKNLNRGTHGQGYVDSHASSVEADVDDDDDSGDIISTASKFVLLEVDDVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1W1</accession>
    <name>A0A922L1W1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1W1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="393" mass="44674" checksum="4CD3D99DF7A604B7" modified="2023-02-22" version="1" fragment="single">MDIDCPMQLRQKSRDIPCVVLAERKQGLKSEKLFVVLKPLVDELKFLSEYGIFLEQFNINVPVKLAFIIGDNLAVAELLGFRQTFGKNFICRYCKSTYAQIRTKLKANYKLYIAGKCCPLGIGKIKGNKNYKSQYGIKFESPFLSVPINIFQISPPDIFHDFVEGTVGDIIKIIIKKTKVGRENLKRKMAIKYVNDKISFGNKEQIIGKAAQLFFTKSIVFNISFKYISMMALLNQFYCKYPTTVNKSNTISNRNYLLSSSSSSSYMFNLIILIIVCIATPIINASDHCNNELIHSNFVEKRIRITSSSDISKDKSVYSTILHGSSLGRQYNISAIGTQGRQNTLEFVQEFKLESGIDGHDYNIYKDESDDCTGGNHMGWSSYKIFRQIHEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1Z9</accession>
    <name>A0A922L1Z9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_012699</name>
        <name evidence="8" type="ORF">HUG17_8723</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the meteorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1Z9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051998">
        <property type="entry name" value="Meteorin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28593">
        <property type="entry name" value="METEORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28593:SF3">
        <property type="entry name" value="METEORIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7637619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9501890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="353" mass="40750" checksum="4E8DBD680FC834C0" modified="2023-02-22" version="1">MDHRILLPLWIFFIVSFIVSSIAITFETIDEYNPIITTDSTINVNHQQHHGYVSDQCDWSGSKSSLLSTLDDNNNGKRLVMPIYLRCSRGQIKWFYPTGGLRVVLKLGTDDSRDFRGCIRIAQNTSRNVRIYIEGKRQLLQIFAADDGQHPDRFRCFVSVNHFIALFIDSSIIDSNISIKYANDPVIFQYDLEEIVSSSSSSSSSSNQSIIDDNDDDPQCITAKTEQCSDDKILDSYCRADFVLTGRIIYYHERIDLNLMEYRIQPFYIHRIPYGQNNTIILSDMDTNSTQQTLILNRPICSNRSMLMFDNIRQLFTGKQILGKYFIECSIGLDQWKRLTNRARHDRTIKCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2Q7</accession>
    <name>A0A922L2Q7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2Q7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="93" mass="11091" checksum="D085696D6A5C0A06" modified="2023-02-22" version="1">MNRNLFPHSQSVLSAWVRLRMAMTVRISFRKMEKTNFQTPTSRKPSFDGFRTTFFPMKMKREDNKKLFNTDNVFIDVVRSVTIGYESFSNHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2Z8</accession>
    <name>A0A922L2Z8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2Z8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="76" mass="8798" checksum="22A190DD9092FC74" modified="2023-02-22" version="1">MIFQYEKRVLCDGKNEGLICDLILTGRNDDVDESSHHTVILLSIIIPLVDCDQDTCDTLYILAMTFLSRWFYRNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3E3</accession>
    <name>A0A922L3E3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3E3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="867" mass="95440" checksum="D0A638965E62264F" modified="2023-02-22" version="1">MAAATYTPPTPMLGHSNSNDNNVENHVSTSSLILDNGVVNSNDGSPSSCSGSTGSSSLDPLLSFNKYSNDNPLLQNHWLPSSSTPRPLPKPPPTSTTKTITTTTNVSESISNSATTTQRLTHSLCFNSLLSSSPSSSGSLSSDDSVISNGRFTADGSSSSSSSTASSPPSIVPSSSGSTQVSSFQAELSELGISLAKLALHAEGAPLIVCDDYLPISITNGSFKSLRYSNGVGGLQSRNGNGGGSLRRRSYRILHPPPPPTTPLLPLPAQYYFHHLAATHAAEAEQQQQQQQQQLQTIRNNFAYRNLAYHQHQNHHGNIMGNNGNYITQQQQQELILSNNNGDNSIQLSSSMNGGSSATATTTKSSSSYFFHHHHHHYHYHHHLQPQSLSQRLNNVMIEDNNISLINNNGNCNSNGNLINQNQSCSIANDDHQQQHEPSYHDENGSTFHHDETDLKMVSILDLYNLQQHQQQQQQQTMSRVNFVKGDDLIRFPSSTNGHHIQQQQQLNNNSHMIARNNLHRINMNHHHQQQNLIPLEESHYQTVISNTNCFQTSEATTTLNTMINQEHQQQQQQQLSPLIMSTSPSSSSSSSSMKNFDPEQLALVDSILEESNTSCSDHHLESSSCSSSADLTTTTTSSCCSSSFYHQESDIVNCFIENSNHHHIDDNVKKNGNNNDDGNQQHLLLQSQCSDSASTISSSSSSSSSSSLLLNSHDDPHNTMMMMMMMADQQPKRLSVPRMLKPRKRRRKTTGVVAATTTTSASSVITNHHFSANDPNQLLTQTTNSSSSLLFDFDDYYHRHHHNNQSTMMKYLSNWTFNSKNIDQNQTVQSLSLSSSSSLLSCSCELVKFGLSACECWKIVVAWEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4A8</accession>
    <name>A0A922L4A8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4A8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="314" mass="37033" checksum="EE5E9121BE811EAA" modified="2023-02-22" version="1">MIGPKKSDNDEEVMMMMITESKFIFYSRINWTNDNGNGPRLSIRSSSTVQHLEQYSKYLYYNCSYLSWRPTYMNTYLQTIKIDSSIRNNNNNNVMANRNNSSCSTIVNSSSSSNEMITLYYQKNLQFKNRFRLDLSSQQCFIDDFPSSSSANLLKNHRYFALSIRHNMTMANMHEEYFLLAKNLSHRLEQVKLLQRKQITNTTVVNETRIEEYLWNICVNKEYNQLTFIDADHECSQSSNERMIPLEIRSDDQKHNITGFIDFDNNYSIWIGVPEKEMLIVLHQFNENNNKQQTAKLITILTKKQLVQCQNEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L575</accession>
    <name>A0A922L575_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L575"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7356" checksum="1E058FC866973980" modified="2023-02-22" version="1">MAEWFSKALANRNTLDIYDMVPNQCPIQWADIDEYPGETPDSLGRMYRRRSNSSSVMMHPKMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5C4</accession>
    <name>A0A922L5C4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TAF8</name>
        <name evidence="8" type="ORF">DERF_009114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5C4"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22918">
        <property type="entry name" value="HFD_TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="7">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9510593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="300" mass="33754" checksum="5EFD5633012A77B5" modified="2023-02-22" version="1">MESSTYPSTTAISARRKVLFAVIAATCQEVGFHSADNYVLDVLMQMFQSFLSELSYTAKCFTEHSGRSEPLAGDIYMALVEMGFNVPSLCQYAQRSNRIMIPNPSYMPKQQPPKILQTGKRRQHPSYIPDYLPPFPDSHSYIGTPTFKQPITDYETLREKSSMQKRDVERALTRFMARTSTSNSYSLFTDKQSHLFPLIGIKMNNVPYLSALLPKDRIWNAQDNQFQSILTANKKSSTLIPATSTLNTTTTTTTGAVDDAIKLNESIDSKDDPLNPNNNNNSVDVIENPFLLPPKIVNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5E2</accession>
    <name>A0A922L5E2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Spectrin beta chain, non-erythrocytic 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SPTBN5_2</name>
        <name evidence="15" type="ORF">DERF_006808</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nesprin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012315">
        <property type="entry name" value="KASH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10541">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51049">
        <property type="entry name" value="KASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="10">
        <location>
            <begin position="1"/>
            <end position="3324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="3322"/>
            <end position="3343"/>
        </location>
    </feature>
    <feature type="topological domain" description="Perinuclear space" evidence="10">
        <location>
            <begin position="3346"/>
            <end position="3373"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="13">
        <location>
            <begin position="126"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="KASH" evidence="14">
        <location>
            <begin position="3316"/>
            <end position="3373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1906"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2200"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2404"/>
            <end position="2429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2577"/>
            <end position="2600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2813"/>
            <end position="2835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3012"/>
            <end position="3049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3152"/>
            <end position="3214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3227"/>
            <end position="3247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="3284"/>
            <end position="3312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1909"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1929"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1963"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="2202"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2415"/>
            <end position="2425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2591"/>
            <end position="2600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="3015"/>
            <end position="3031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3036"/>
            <end position="3049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="3160"/>
            <end position="3169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="3199"/>
            <end position="3211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="3285"/>
            <end position="3312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9516044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="3373" mass="393988" checksum="4A8E1A90820F8612" modified="2023-02-22" version="1">MSFSGDNFYCDNARYERSKIGKLRNEREEVQAKTYKNWINSILIQGRTGIDNIYTDLAKRRKINHSIETVDRQGLRFIKSKNVYLESIGPDDIVNGNKTLTLGLIWTLILRFQLSKHLDFEQYDLKSIKESLLLWCRNRVKHLEFVEIVDFQQSWQNGWAFIALVHSFRPESLDIDGLRRRENRELLAIAFDTAYQQLLIPKILDIDDVINEPDENSILTYVSFFYNLHSRTKNSETNVKRIQYLLTHISDVDNMQDSYINLCRALLEWITSKSALFETDVPVNQAQDAMLEFNNYFFNERCEKLKCRNDCETLYFEIISMQKETGIKTFKPSNGLKVKDLEKSWLNLEVIETKRLSKLKNLINQQRKICQQAELFDTKSQKFENYIVSKLELLNKIFMIEKPVSLQDLEQHLQQSEAICLDVHDNNMKFDSLISLANELIEQHYGDSQFYSQYLSHIDGKLKRLHELASTNLTTIELTRHLFTDLTCIENILNESHDLYGQINSIGISNESIDSIQKILLNLEKLKYLEIYLIVLEKDYLESQRQFDSIRLDDKYKYCFIIFDIDIYMKKLTDSKSNIVLCRDSIERLKKISEYQIHLNEFITSVECLYQFLNEKHTLTKTDPNDCFNCSTIHFIQRRNNIIKLEIKVMERELYSTCKNGYLLMNSKEHNDAIDELIKAKIEKIKNDFKNFIFTINERTLLIHDCITLYNLIDELRQHEELIKNLNNNFYESILEKIDLYQNDSLYLSEIFDKLGQLSIRMEKYHSDDGQDNCSKFILYLKNYQLDLNNFRPSHIYLIIEINLPDIHLDKFRTIHLNLFELIRDRIDHIKQLISVTRSDFDVRKLKQMLNVKCDDDDKIQNDEITSIQNMPTVAEIDLIFQLFFEQHQHSPVEFEDSLYQRNHFVISDFRNMKVLSTMIKRTMNLLKSARDIVDLCQLNRSIPEEPVFDEMTEIIPIIDNERQMSDEDFSETIKLITTVDAENVSMMTAEDDEKISIVETESEEQKRMALIMKKRIFIHKLKNDIVFIHQYFINSNHQCQDLKFKLNFLRKIVGNNVKRIEIYIIEHPDDNSTEIIQTLSNELQKCDQEIDKFQKLSTFKDLLDDFYLNVNNHFDNLKCIQIINYNDLNEKIVRNDMRTIESIEISYIYYKDLFDEFRQDNICYFDGELDKYIVDLTFILEKFGLTIQTTKELLEKRWKYLQEKKKQTRIESFMKRLYKKENKNPNTRMEEISATKVEQSVESIPNEPEYEAYFRNENDFTDSSKLENLIREIEIILFDINCGINMHRYKSEQIHAIYNEAIQLTDDQTLLNKLNFYKKKMDMIIKKRNYRLELEDFQIASEYFLKCCKQDIQTVDEFTQKITRLPINADHKHLINAKMLGLKFNLRHYKSLIVMIQQNHGNSRQPEICSKMVYLNDSFKELESKINNLNDISNIDEEYNLIQSKYLETLKELQTKTVETIEQIDCFKNNKLIKENSFEQELNDLDNSINRIAIIIRYKILKHELVKKLKQFENRKSIEDEEFQTFVNEIRSQQEIMDKTLASFDFTLNHGEMFDQIMTNLEVLMKKLDSFSYIIEIDSHRKLLESTDVIIEPKNIRPSSKIIKRIINKKPKKITEIKTFTLQKSEHQPSFDFDSISNEDLINNNYTTPVKYFDDITEHLIKSTTTILNENNESSDEDSTKIYEVYIELENEPVKDEKPKARLHDEIVEVYDEFEEESQDSPNDHLVKLVNDNTETSSIHESEEFMETIVVDESNEELSSMENEQPSAIKKLKTKRTNMNQSAEEILEVFIDKMPTETIINGIIDDNVKQDVTIINHENISITKVHIRDEITEQTTSGDKIDEIITDPSTSNLKKMKKFKSNNYNNSNNVLSQAPGINLDVLNEMIPIDSIDIDEESYSSTNVLMDPSSIQLNNPANKNDRQKQQQSSKRKKKSKKKSKLRKTIQITSEITDPVLESNHLSAADDKKSQHQGDDKPMEMSESKLISEKNLSRIVENSEQNYYRSEKFNLNVSYDDDWLDYLTPKMKTTSNNVYEISLNRKNNNDEKLDVNQTKISIDNEKTKLKNQTVQQTPDQNDDENENVTKIEYLPPTQSLSFDIINENNKLFDNNGSLEETDDIVERCNNIEPEIDEALSKDDLKNSEPINFESTKSISINENNVDIPLSNSLRNILHNNNEIVDDIDNSSEILANTFETTKITGKTSKKKSKKKKSKKGSSSSLNRIEKTCENPSTVTLDSIEQKILSVIDEDIGFDNIPMLQSENFKPSSIQHTTTVDSFIDTENISPSIFKLPSSISDDWLDYLHTADGTANVSNYNNEHINEDTVMNTIQAKIITSNLSDVLVNTDKKTLVFGENIINESKSKNSKKSKKNKKRKFNKWMEYQNPETNDDHSSISDLPDKYDQVEKKDSSIVPIDQSVVSSKQSSSKPDRKDIIDKFNELFSFSNLASIENRPSANYKPKQIFHSDNDDQMIHEENDQDDERKIFESIIETFDENDPKTDSFENIDSIPILIHSHKNIVSNDDLEDEETNKIIVMDESMLITDDYDHSPLSIDSNKKDSSFNNQQLKIQQFEDLIQSRINQQSSKSTKSTYSKKEDDETRGVKLDLTDEQPKTVKNMNLKYKNQTEQPSVSLNDWIDYLTPATSIPRPTNDFNELINWNEIENVHCDLETNSKNDVHFDSLKKTYSNQNLTSIKIISQNSKRKQTFFSSSDDWMDYLSPQNLKTSEHGLQMSIIYQQETKTNFSYDNNIVQDKVHGDNQNDLKSKEIEMNKFDDNPESIKSTKPFSDDWLDYLTPQVFYVMKSEFQTSILDQQPLESNSGEKFHLPNQQESDESKMDKKKIKESMLKNSNNSEMLLFSEFNHEYADRAIPNIKITTLPITITESNEKDISDPHSILIKSDYSTGDNREKKAAVDQYETKSSMDRLKFIDSNVSKKVVNKFHIPVSSYDWLDYLSIKDTRTQKSDLKMSIIDLQPLENVDKEKLSNSLDISCTKSIKISNTSSKQFDMTTCKETKSSFESSEQNKRLSQNENQNHLHRMNENNDTNDKISGEKLNSTITTLQHNITQLMLSEIGKKSATEQKNDIVGKCSQIDSDENLKSQLGPIIDDDDDDDDKREKFGIQVVKNKNLMTNRNRTLPLPTFSISLSHDNEHSFQTGLKVQKPSDSKEPKTKTKQRRNKTEFFTNDGDNDKELIDKNPVQSSKSSSSSSSSPSTVNNLNFSTMKTWNNIRNSSSSDNDHKTLSATKQAKIRSKKIRKHCDVKSLKVIDMNVLEAKINGNRYEKIESTQKPIRNPKSSLDTIIDNSDNDGSSTPPSTQIKRFKRIFQYSLPFYFFLLLLLLLFLIIPKDENEFNCLLRNDYTMTLKKIYLHGAPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L758</accession>
    <name>A0A922L758_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L758"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="91" mass="10568" checksum="F5418F8CD296B4B6" modified="2023-02-22" version="1">MFPSIVNRFLTNVIIANNDDDDKQTEKKISTSSKCFDDPMFICGWKISFSLYTYATKWCINLLEHTQVLSKFHIHSFILISTSKLEQNGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7E4</accession>
    <name>A0A922L7E4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7E4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="209" mass="23145" checksum="D13708C034D70ED3" modified="2023-02-22" version="1">MVQMKDEDDDVIDVYDVNDYRQQLLMAVVVEQDDVAVALDVVSLIAAIATAVDDDVDGRRLVIIDGDIVTLLEPIFEEEKVNASTLTTDDDDVKDLVIELDDDELPGKNFGKLFDIDDDDKRELNLLPPPPFTKPTELDDDGSAVGIELEEFTIEAAGDGGRGANEELVEGDVISGNILERLKFVAVDRFDDLLLFDLDVDRVTELLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7H6</accession>
    <name>A0A922L7H6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein unc-80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">unc-80</name>
        <name evidence="7" type="ORF">DERF_006250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046460">
        <property type="entry name" value="UNC80_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045852">
        <property type="entry name" value="UNC80_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031542">
        <property type="entry name" value="UNC80_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19424">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20262">
        <property type="entry name" value="UNC80_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15778">
        <property type="entry name" value="UNC80_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2420"/>
            <end position="2438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2450"/>
            <end position="2470"/>
        </location>
    </feature>
    <feature type="domain" description="Cation channel complex component UNC80 N-terminal" evidence="4">
        <location>
            <begin position="52"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Protein UNC80 central region" evidence="5">
        <location>
            <begin position="1549"/>
            <end position="2323"/>
        </location>
    </feature>
    <feature type="domain" description="Protein UNC80 C-terminal" evidence="6">
        <location>
            <begin position="2324"/>
            <end position="3389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1211"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1833"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1892"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3393"/>
            <end position="3419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3451"/>
            <end position="3482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3524"/>
            <end position="3592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3606"/>
            <end position="3713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3873"/>
            <end position="3914"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2274"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1902"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3404"/>
            <end position="3413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3454"/>
            <end position="3474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3524"/>
            <end position="3542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3582"/>
            <end position="3591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3611"/>
            <end position="3626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="3629"/>
            <end position="3638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3657"/>
            <end position="3676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3677"/>
            <end position="3712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3873"/>
            <end position="3895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9522684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="3914" mass="441847" checksum="F2E832707FC314DE" modified="2023-02-22" version="1">MIKRKSSHSGGGGVGGESNGDDTHNNDKNNNKEEEKEEEDDDDDENDCLSHSIPLPIQTFLWRQTSPFIRPKISKLQDAAAMEQREACKLFEKVLVQNIRFGLSPSLTKAIASVSRWRLIVSALPHVMHCCSTLLYIRRKNSFDKLSASETKLLYTLHWILLDAAEECADEENEHGINRPQEHYILPVTTIQTFVYLFAPLIPHLKQSDFLTSFRLENGYKIWIPLFNYCHPEIPSFLAHAKQNTFSLSRNMEKKLPIPKFGDVFIGSSTQLDKSAINVIDDGGDKKSTTMMMMMNTERKDSHDIFNFGSPQPSDSSPLHMMNGHDPLSIPQQQQQQQQQSSSSSTTTTTKTQELKKKYEYQKKDLAEPSMATYLDVAVLRCLFTSQWIEDGIDWALNFLYYRLECIEKSRQNQQQFFRTRSYSLPVPKRRYRDSTMFATAAASSVGGGGLTNDSKRNRPNDDQQHHDQELNKDSKLKTFRDVRRSSFSGLPGLSGFQALISSTTSSASFGRHGSEKVKHKKSKKQQQQQQNQNQTTSTVDCQQQQQQQSNTISSTSSKIYHKTINNAISSHHVPSKSDNNQSNKQQQHHHGHHKSKNSTTKTAKQTIRDVVLSKHLHYHYHGRGHGHQQSSKSSTSVTEAVNDQQQQQQRPTSANSFKKRKISLSTEHRLIDRNDFKGKSMPTLHLIDDENQPINFNDEYYDYDDDEKYPAIYLSPETARTPSRTSLTEIGGGISTTNDTQLLNAQSNNTNQQSTSNVPMFPIITITEHSPVSSIKFFHNNNNQNRLIDDNIGDGGGGGGAGSDIDDHDDDDQLSIRRRKSSSSTSKYKFYIADDDDDDYNNNQQQQQQQQNEMFYSSAYYSGGRSGGGRSATLLLRCKSDGQIDYTIETSGESLASINYVNKNGQLSLVIVLKAIHSITLKDSVCTMRVCKIIHKIINKLMSFKLISKRIGSIYIAKKFKTFKPNCENPELSVHHLFMDTLFRIIKQLGCSRGCGEGRREMEAIRLKENVMKTLKSLYDMSELLFLQYCEMLVTSHPIQEIMDIFHAFFGFCSEGTTTATTTASTNVQQQQQPPQTQHLTTFSIKKSLPGTGITSTGTQLKNGYFNNFGAGFPTNDSSSSKLKLEVDTIIVKYTFKPFISRLVFVQKELKVQENMSLYCEIRQFISYVREYHGGIFRNAALSGLLESTKFVLQNDRLWISKMALKDLADPQQRSTNNDSNIQSKDDQTTVQQQQQPPPPPPPLSSSSSTTSRIAKHKKWGANRSKSTLIVEYNNSDSISQELISPIFPPIVAQQQQQQSSSNQRNQQMELQLISTTTTTVLTGSSSLNPIQSKMDFFAINDPISPSTTTMTTQQLTSTDHFMMMNNSNINNNNNQMNNHNNNIQRDFDGGNLPNYLTIASNNEQQQQQQQQQSPLSVTLMRRGSFNKQTLKGFSPANQSANAFAITITAGNALNQKSTFFKARKQFKNVFGGKNKFKQNSFDDTPDLSRKNSLQDIDRLQQQQQQQDGVGINTTMAVTTGSGGSGGTTGIMTTNVDIPLKKSRTILFEILKDGMLKFQFLLDSCTPGSIPDAQLVAAMLDLKAPVLARAAFLLECCHFVHRCNRGQWPGWMKMNFNFFRPSGPRHGSQTVIKSRASTTLQKHAGRCFYQWAELLSSRLEDILQNDIDMMQSITDSDGNQQIQQQQQQQQQEDNFLSISCVDSKEGNCPFALKIIACQLLYEITTYLRETHQYLLTQNSRRTSMVNPAIVAAVASAKEKSCIEPPRPLAMHQNRRWSMALSTGTFNNSAHSLMSLANFPGGPMHVLEHMLPPSDRRISFVLHEAEVGPSSLVTWSGSGIGRSGSGHHESFRRRSIKLKKNDSGKKSTAKLRSATLVEDDYKSMFKRSNSLRSKRKVSGASEKSDTSERYSGEESPGLFSEEGHSFESALLDNNIDTNDVDMVENIPWLKITTLFASAINFECNHHQTCTHNCHKKIIQSASLLTKEVQRIYEKDVQPLFDFDMMAQKLLDDKEDVAKKEKKLKKILMGHASPLKRKASGLQMDKYLDRDSHGHSVYNSQTGLAHSAIDVEYGFYESEDPRLIFHDVLSYRLESKHEENTTMLYILNQVKNPFHSIISMMLKSALILNRNQFEYLLNLSWNLILDEDIQISSSASVAIIVCSLKCPDIVINLLNQDLNHQNVDIRVNAINKFLKIWCNRHQCWQRLEEGAHLVLKLPPAAIEFTIPSPRIALECKPVVDPPYMPIVKTKVDEVAINQEPTIQKSFVAATKTRRKQQIELISKALQDQEDKLREERENYRFNSVPVTLQAAYEPVLYHTIDDHDDQEDDVERIPLHHLQVAQCFFPSSLTTASFLIVNLLEDTQINSDGQAVYDVAYKTIWHCLSEDSALFLRNLLEKLTREKKNVVIQTIRRLIRFVPRLPAQAAFTLYNYLIGFIMYHVRTPTEDSQSIIASVMSILWLIVPNVFGLFLKDLKQILRKEQCDSTILITANVPSAKKIIVHGPDPGSIPSQFPVHEDTQFSQILTDSLDFFGIDETKHNEYFLVDTKTNQIHNLNAFVRDFYFFKRSQYPQISLVHMNPVEAYDKFQQQAFTLQFTELGKSLMSLSLIKTSYMGIQRVLFLHEELMKLPSFPRKALETNLTLYSGPMGREVLGLDTLHKISWVKLVGRMFEATSGFFADSTDIHLFLNVVNGTLLLHCEDATILRLCMATYINAAHQFKNIFATNGYLLIVQTIVQIYGTHQTNSLLCRTIEFVFKQFYILHSKPFVLQMFGAVAPLLDTDSINKYESSCQISPKAFFQLLQSLGQYTADPLDILELVDAEKPLKALDFCYQMDSETLTVLDSISLCVTVISYAPDSERGHQMLTILDSILPFHLMHMQTLTTKKETPGGPRAELSMIHNISVCIKTLIYNCEALTRNFTGPQRTLDIRETSVKNLSPHIEIDEDSHSKYNAETYYPPRHNRVELDDGELCRLEFRKPRDLLLKIVSEFLTKSTTRFAELSKKIAEIHQKNSSYELLDVKCHIRLAEIAHSLLKLAPYDPQTMACKGLVRYMNEILPNSEWRQESMRPALIMVLRRLDKTFTKISKKSAIKRTTDWEAARRLLKGVYLTFAKHPYIVHLPHLKSLINVCQNIIIGDQTSYFLSESSSAVSSWTTALSQAPPPGNASGFTSVAVRLISLQMIQLGDSQSLETICSGAFSSPEKSEIYLMNMIYPMCIRTTSGMKDTPKFRLCDINFVLSVILNILKPANSKPTKGSDSSQVGAQLKQFSLQQIGFLGLKILIICFEKQLNTEWYHIAKCIRDLADKPHLIGSTFWNFIDFISTYRTPLFVLMLPYIKCKYLLKSCENGIEKAYQLRIQEKLNGSGLPFNRSKGNLYVSLVNEMKSLREDIIRRKNNPNIDERSKSIVQEQNSASDKQENSGHRLSFAFSQLAASASKLSNISSTIQPNTAATVVGQQQQQQQSHGSQQSSYGEQSLNSPTTSIKPRVLRGLSFRLSSDSRRLAQRGLSVKLASNQSDKRMFARRTSYPDHPDVDECGDFKHPSGSEPKLFRKMTLSSRASKAHKSSISSSGEALTENVPPPNSTSSSTMNMPIRKETSFTLTTTNKEEIKQQQRLQRQQQQQQQQQQKSSTRKSFRFKNRSSISSEEHSSSTTKSIENSVSDLHNNDYNTQQITKPTSILKSSLKSSSSCDNEQSNIQQQQQQYQQSLTKSSSADQTLPITKINSLVLQQQYSINNCDHHHHHPPTLPSATILSIQNQQQSKGNMVPIVVGQLPLKTSMIEMNNNQTITSSSSSPMMTLTTTTATFSTSTNATSMTMMMSPIRTTSATPTGNNNHHQSSTATIGSQQIISTIDNNLDNTQTMMMNATMTTNGGHTNQLASSSTTTTTTTTTTSTTTAIPFETSIQASLPFADEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8L7</accession>
    <name>A0A922L8L7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8L7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="20" mass="2109" checksum="D2DBAAC4105F84A0" modified="2023-02-22" version="1">MAKVNGGLWRHSPGNNNGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9F6</accession>
    <name>A0A922L9F6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_006162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9F6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037908961" evidence="3">
        <location>
            <begin position="28"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9522597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="794" mass="92695" checksum="E25A003D11F7520E" modified="2023-02-22" version="1">MKIIIKQFSFGLLLSFQSSMLFVNTLQQNRNYDDISVDQIIIPYKTIYGIPNKCKKISEYRTIEQNYQSCQLNSLKKWQITVDQYYTETLNFCCFVYDVLNCEIKVLSICDSEYSNQNERETRRLFDKSCKPIIKNDACNIDDKDKWKEYATYAGIAIAGIFIIIIIIWGGRKIYYRITTTPEMKAMEAYKKEKFEQLLEMETIRTIYDQEVDNLDNIWHESTAKTIKSGKPTTSSSVVDKRDNVMTTLSIQNKGFKEKIRSDIETNSKNTNFWNDFHANSQKYYADSSSSNLVPKKNMKERFKWSKKKVKNGKKDAMNRDELIRTEARLQYEDIKKDNRRRLTDDKAYYAKIKKETAKNMPIVDREKLGKTLRPRKKLEQKEDIDPLLAKTISILNQEQIDIHHEMLRTKRFAKFEKMDQLEKWSKTLKETRTKTRNDRNKEFFGEPVKILDIPVIDDDDLAFDFEPEEEETAIIASSSKKLSTKKGKSKKDLKSKDKTSDQESVSSSSSIGSVSDDEKTKSSMKNKKKIKPWWKPQTQQQPPPPQQQQQLSPPPQQQQQPPPQQEPWWKPQTQQQPPPPPQQQQQQPAQESWWEPQRQTQPKPKQKPKLKDDIVIIDYEYVYLDHNGNIIKKEEGQKEAIASNNTFSGKKIYKKIQKLIKPDDFEPGVTRIPTPSPPPDLIIEDVTEDFPPPKPNQLQLGWKDELQEDDETKDIYIGDDVERSETTTESANEMVESRNIDQCKQQQSSSQSNNESTTTERIRKSLKQIVLSTATELSPGDQQYINFDEKFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9H4</accession>
    <name>A0A922L9H4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4 15">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">DERF_008709</name>
        <name evidence="19" type="ORF">HUG17_2743</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">JKM2019</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4 15"/>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9H4"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.230:FF:000001">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000004">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="18">
        <location>
            <begin position="15"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="17">
        <location>
            <begin position="126"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH7638710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH9518112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="425" mass="47829" checksum="DB53E32463B872A4" modified="2023-02-22" version="1">MSFIQIPADHPFPIQNLPYGVFSTESESRHRIGVAIGDQILDLSKIVHLFQGKHLKDVAAKVFNEPTLNKFLELGKDAWHEARQTLQHLLDKNTATLRDDSKLREIAFVPQAMATMHLPAQIGDYTDFYSSLEHATNVGSMFRDPKNALLPNWRYLPVGYHGRASSIVISGTPIRRPNGQTRPADDEPPKFGPCRLMDFELEMAFLIGGQENSLGQPIPIEKTQDRIFGMVLMNDWSARDIQKWEYVPLGPFLAKSLGTSISAWVVTMEALEPFKVANTPQDPKPFAYLHHSDNYNFDINLNVFLKPDGMERNLICKSNYRYLYWTIKQQLAHHSITGCNIRSGDLLATGTISGPTPDSYGSMLELSWKGNRPLNLGTDGVITRTFLQDNDSIIMEGYCQGNGYRIGFGDCRGKILPPLILDFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAF3</accession>
    <name>A0A922LAF3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAF3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="84" mass="9987" checksum="89377A913D71A773" modified="2023-02-22" version="1">MILNRNCKLDNNNDDENDMLVSVYVCKRPCHSNQTKGIENEENEMKWNDDDDDDDDHINNRYYPYRENQTPIILPTITNSIHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAH1</accession>
    <name>A0A922LAH1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Complex I-SGDH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase SGDH subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NDUFB5</name>
        <name evidence="18" type="ORF">DERF_003351</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAH1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019173">
        <property type="entry name" value="NADH_UbQ_OxRdtase_B5_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13178">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SGDH SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09781">
        <property type="entry name" value="NDUF_B5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9529466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="198" mass="23168" checksum="97BC04643A56042F" modified="2023-02-22" version="1">MTLLSTLKVLARNGVIRDCQKISVRFSGHGHKMHIQPSRFVWSTFKDYLHFYFMLGAIPLTLITAYANIVVGDAELTDIPEGYTPHHWEYYKVAKIIKVKLSLTYFKFHPITRFFAKYCFLDRALAYESSVSKLAEESEKILIHRVKQQLKMMMAEKADNKAWYYTEVDPAQNRWLLDKFRTIAFKTEGISDRGELDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAH4</accession>
    <name>A0A922LAH4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_002306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAH4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9528353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="817" mass="92482" checksum="B78467CAEF1BEEFB" modified="2023-02-22" version="1">MEQLQLLSSLSISDIKKFDGTNFKCWLDEIKLWCDGYGFSELLELTSIENVNADKKKKLKMLRARILCFIREDIREAFLQYDLPSEIINQLKDRFDKQNQFHKANLVDKLMNMKLKSDEDLMVYLCRFDSLVLQAKKAGAELQDDIIINILLNSLPSDYDKIKEDVLDSTDISPISLDRVKESSSDQALRVENPRGNHRENFPTVNRNCFKCGGVGHFARVCPSGRYVNEQRRYFVSSNSGPQNQLSSNNGAQNLRSSSNAQQSAPSSTNNNARNSQRSTGGAQRNARPPANNNQRAFVSQDENIENESGHAYSTTNVDHNASLSDWFIDSASSKHYCNDENQLYNRRECFSSVLTANGDRCQASSVGDLDLKTSDGSLMKLKNVESVSTFDKNLLSVPATCDRGNIVVFTDKECIFLDKNKCNLNYDESAVKMIVPRTGNAYIIKANRINSENYANSCNDDSKVISWHPDDVFVRRNSASLLRKTIDSLEEVDENTFAEVLKELRKRSVDKDKYVRSLIMLCLRKLQYINKDDDEAIQILKFNPLNEDSKCMIMPIAQNSILENFEMTKCNPTIVPMDDMEDFTNCPIDDKYPIKEILGSLNYIACRSRPDIALCVSYLGRFADKPSDKLWTACKRVLRYLKGTKHQQLKLLPVNEWIINVYTDASFRSDSSSNATSGSVTLVDKSLINWSSKKQSRLPHSTCEAELTAALEGWKNAEPIRQLLQEFGINSSVKLHVDNSAAVSIMDNNAFKKSRYFAYDQKLLVSKMNADNLVSIARVPSSDQLADALTKPLKHIKLNVFTSRMLSQKGVLHENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAZ5</accession>
    <name>A0A922LAZ5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_001248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAZ5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF77">
        <property type="entry name" value="GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="182"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="365"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="639"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9527217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="789" mass="90038" checksum="1DFCC9482830869F" modified="2023-02-22" version="1">MAAVSPTLLAVLTIGVVALILGIFIGMYTIPPTMTPENAAIVNEYKRLIKNYYDAQNDDDPVYRALIQGPDPDSIRKNIQLLSIKPHQAGTKRDEELAQFYKNTFRDAGLDRFHLIPYKVLLSYTNPDRPNRIYLNDKSTNAVYVIDNQEPPLRPDESIIIPSYNGWSPSGDIIAEPVYCNYGLIDDFIQLDNFRIDVNGKICIIRYGRTFRGNKVANAERFGCAAVILFSDPESISSSNNNEPESLYPNSIWLNGKAMQSGSIRLNDGDPLTPGFPSIIDGFREDHNDNERVHLPGIPAQPIGYDDVQMIFSQMTGMSTEDDISFQNWTGKLNTTYRLGPGFQSPSLELRMVINNEMVEKIVHNVIGILDGDVEPDRFVIIGNHRDSWSYGALDASSGGASMLESAKIFGKYHRETGWRPRRSLIWASWAAEELGLIGSTEWTEQFAQLLEREVVAYINADICVDGPYLNADSSPSLASILIDSTKRIPAHKINNNDDDNESNQTLYDSWLANSNTDEVHVEILSSGSDHVPFAYGLGIPSINLHFKHDQKKYPVNGYPAYHTNYDTFYMVKTFIDPDFHIHQSCTRLINMLLYSLSCSTIIPVNFRHLSRQILDDYQRQSMDKRLRDILTVDGSQEQKSINFLRESMKIFDNATEQWQNQMKNFNFTDQPLAIRRMNDLIIMIERSFAQKLLPMDGNEELKNLLYGTFNKDFYQTLLFPGMNNLMAEINDQQLRKRQQTNRLTREELTRIDQQTNRLKQTLRRHLNDVSLALRNAAKLLRRNIMPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB84</accession>
    <name>A0A922LB84_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Eukaryotic translation initiation factor 3 subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EIF3F</name>
        <name evidence="6" type="ORF">DERF_004091</name>
        <name evidence="5" type="ORF">HUG17_9402</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7638296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB84"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7638296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9530276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="303" mass="33327" checksum="B1E6F64CBC47B2BC" modified="2023-02-22" version="1">MSNTSVRVHPLVVYNIIDIYERRNLDANRVIGTLLGSVDKLGNVEISNSFVVKHREANNEVAVDLEVAKELYELHKKVFPSETIVGWFATGGGEVNEYSVVIHDYYSRECQNPIHLTVDPSADGISVKAYVSTIFGIPGKNVGTMFTPIDDISISYCYEPELIGVRACMYAAGLPSVSTDSKEIFLANELDQIIQMCNKCQDDIARIVKFIEEKILSGTSKVSIPSNTNDIGRQLMAMIENIIPFGGDDDEAFNSNLKDFLMVVYLSNLSKTQLGLNEKISHLLATERPAITAAGHSVPSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBQ4</accession>
    <name>A0A922LBQ4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_003726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBQ4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="9">
        <location>
            <begin position="72"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9529868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="297" mass="34200" checksum="11E99DE1B1E58690" modified="2023-02-22" version="1">MSPVLFSRFQVFKYLDTIQNWSTVIIMQSIESCDHQHPQHQHSIIDHECSAASCNLWCQWIKISNTAAVDMNNISTNQLGGSFSNGKPLPFDSRLQILAMSLKGYRPCDISRRLLVSHGCVSKILAKFHKTGSILPGTIGGSKPRVSTPLVTKKIYEYKLANNSLYAWEIREKLRHDRICSQDNLPSISSINRILRNANQINQSYVQNQWIDWLYMNSCHHHHHHSDDDNGHQQSEQPSKIDNNNWNLEQRTNTMIKKKYKNDINNSVAYFSKQKSIIKAKKSFLIKDLLGMGCRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBX7</accession>
    <name>A0A922LBX7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBX7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9530094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="7317" checksum="3CC73F92B7946481" modified="2023-02-22" version="1">MEILLSSSSSSSLLLVMEFKGIFQNFFFRDDWRRLMTIVKLKNHIPTVRLIIVKSNHREHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LC18</accession>
    <name>A0A922LC18_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA topoisomerase I</fullName>
            <ecNumber evidence="9">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TOP1</name>
        <name evidence="13" type="ORF">DERF_006306</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="9"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LC18"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46596">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, dispensable insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="12">
        <location>
            <begin position="459"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="743"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9522745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="855" mass="99863" checksum="F4158D199EA86B7A" modified="2023-02-22" version="1">MANSSSADESDDQHEQQQQQSDDDDDSQQYHSRNGNGKYDSYDDDEDDDNDNSQDYNNDDDDDSQRSEMKSEPDDSFGMVSNNNNNNNNNTRSSNNNNNSMLNNHHHSKYKEESDSNDDDNYNNKSKKKKKRKHNDSDEDDYMPKKTKKSKKSDTKHSNNDSSTTTTTTTKLKKKIKREYSDDDDIDNDDDNDNESDYSDSEYKSSSKKLKKSKTKHLDSSGGDKKKLKNKKDKPSSSSTSTLAMNDGGMKTKTVKTKSEKDSKSSKDNNKKSKIKKESSSSDGKVEKKRKKKQEEEDEHIWKWWEEESPGEGIKWKTLEHNGPVFPPDYEPLPKKVRFYYDGKHFELSSEAEEVAGFYARMLEHEYTSKDVFNKNFFKDWRKTMNEKERELITDLKKCNFHELNEYFKQQSELRKQMTKEEKQQIKLKNEEIVNKYGYCIVDGHKQKIGNFRIEPPGLFRGRGEHPKMGKLKKRVQPEDIIINIGEKVKIPTPPAGHKWKEVRHDNTVTWLASWTENIMGNVKYIMLNPSSKLKSIKDWQKYEKARELKKYVNKIRSDYRADFKSREMMKRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHITLHSEKDGKQYVVDFDFLGKDSIRYVNSVSVEKRVFKNLKHFIVDKSPGDDLFDRLNTSSLNKYLNSLMDGLTAKVFRTYNASNTLQQQLNELTKLDMTMPEKILAYNRANRAVALLCNHQKSVSKTHDKQMENLNGKIKDKKTQIKELKKQYKETKNDAGAKEKYKKKLKTLEEQLKKLEVAKVDKEENKQIALGTSKLNYLDPRISVAWCKKWEVPIEKIYNKTQRDKFRWAIEMVGPDYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LC26</accession>
    <name>A0A922LC26_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Piezo-type mechanosensitive ion channel component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_006335</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIEZO (TC 1.A.75) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031334">
        <property type="entry name" value="Piezo_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056770">
        <property type="entry name" value="Piezo_THU9_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056769">
        <property type="entry name" value="Piezo_TM1-24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031805">
        <property type="entry name" value="Piezo_TM25-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056768">
        <property type="entry name" value="THU_Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF2">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12166">
        <property type="entry name" value="Piezo_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24874">
        <property type="entry name" value="Piezo_THU9_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24871">
        <property type="entry name" value="Piezo_TM1-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15917">
        <property type="entry name" value="Piezo_TM25-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23188">
        <property type="entry name" value="THU_Piezo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="801"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="967"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1078"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1135"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1163"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1186"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1243"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1302"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1325"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1358"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2034"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2071"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2119"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2330"/>
            <end position="2351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2371"/>
            <end position="2388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2400"/>
            <end position="2418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2438"/>
            <end position="2454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2546"/>
            <end position="2569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="2831"/>
            <end position="2855"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM1-24" evidence="15">
        <location>
            <begin position="84"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo TM25-28" evidence="13">
        <location>
            <begin position="1291"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo transmembrane helical unit" evidence="14">
        <location>
            <begin position="2027"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo THU9 and anchor" evidence="16">
        <location>
            <begin position="2328"/>
            <end position="2568"/>
        </location>
    </feature>
    <feature type="domain" description="Piezo non-specific cation channel cap" evidence="12">
        <location>
            <begin position="2605"/>
            <end position="2922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="876"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1630"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1785"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1855"/>
            <end position="1883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2170"/>
            <end position="2230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1804"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1855"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="2184"/>
            <end position="2193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9522775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2948" mass="340037" checksum="18D98AFEBACFF8AA" modified="2023-02-22" version="1">MDDVSKISTMVATTTTKTTGNTPTTIATQNRQKTSSQASTTAAAAAATNSTANINKTMDISLTLCYLLQRILIPCTLAAAVLLRQNLLSGIYLILLLLAPILPSPTPENVINGINGIYLKSIIVLSSIANSAHIITQIILLAAFNYSTSIDYCTNIGKIMNLIGLHRYNDLSFFNIIRLCCMDFIVLLITCLVLAFSSHTYHSKLDTSIGDNITNDIRFQERRFTDVSYVGEMSGRRFTNRQSTMAAPSKRRLKREKAERLSYYISEFIFFISLCASAILEPSLISSIYFLYFLFIGSWFALDRQFGTGYHYFRLFIAIFVALHFSLLYFYQFSMFYPLIPSTDINARLFGLVGYINNTCSDVRHFQLNDYHFVRFLHPLVLLILYFVSVQLIRTILIDKKLSQLLRTNRLNRTYHSIRGRADSMIEPQTLQHNHDRNNDELLTNIHSQQQMSTSLPPSPMPLSPTPTSVLPGGGGGATSRDQSNQFSLFCFEFVTMVKRASYVITLIVMMTWSITYHSWLSFVLLLLSCIIWMTPNSRETCLRSSPFLVFYAIALVIGQYIYSLNLNDTELPITIGSISIGEIGFKKYGQFSYQPLFTKIFYTMFFWITLRQYTESLKDPIISDYQSSSSGILSPLFNLGPRATTTTTTTAAIVQTQAAEQQHFETQQQGFTSQSEIFDSMIKCFKEILIKYLIWIVAIMLMVMSLSGSKVVIYRIVYMFLFLIFTLLLLFSLKWWRKLIYPFWLIVILYSMIILIAIYTYQFNNFPKYWEQYLHIDRDLQADLGLVVYDDDAFILFKELLTPTFFIIITIIQVHFVHKDFLKSSNIDEILDRLAATSPSLNNSVALDLCLETRNRIHQSDTSLDPSIVVDNCPQQQQPVSTETDRSKSQPSQSEEISVQTVISKRNIKPTMDRRYYRSPSMARSESKSTLLLPSTMKPTFKEEILQIFFKCIHHLRTIIDQWMIVFWRFLEVHIMKAVCLCTVLIAIQDVSVVNVIFVLLTIILMIFNRFEKMICFMFALWAGLLILLKMLFQLKIAQKIDWNTTCTTFDSTNTVQVVDNRAYIGFLKTDDIFSYIWEYIALIIMLVFRTVILLRQYLYRNHEYGNRPLLDGVIFPDVDRAMADKDFANFFKYLLNFGFYKFGVEICLILMTITIGNHGDIFSVLYCLFLIAFVLFNRSECRRFWSYLVGFMSIVLPYQYLMCLGIAPGLCWLYPWHKLPPADFDWYFLPDFKHQLPKQKLYLDFLLFFFLCRQLFYFRLESKLIIYGGSNLEASKEQTPQNVFDFFSFGNTLFDSFKSYFLFCFFWITLAVLFLAGTTRINLFGLGYVLGSFIFLWNGNEFYLKPSRMIFKSWKTIIGYTCMAMLLKSILQVFVLTFLRNNMCWAVQLMGLSYHQKESSSIDKQTMELLAKCPSTDSGLLWDGICFTFLLIQKRIFCSHYFKYLIREIKAQQFLAARGAELIHEIQAQEVAEQEIAEREVMEKIKQKMDRIKEAQQRMFANQARSIKYHKQDEYDYDISPYVGGVGGGDDETLSQTSETDDLFSALSQTLPTVYSPTPSVPTITSPQSATSLQPGYFEVYNVWPIRPIDASSLSSNTFASFSFGSGQHSIAAAGGAAVSCTKEKTSPSIYGHQQTGSSIRTRESSSLTTRNIRTDSIHRRISISPTSIRVPLQQQKEKKKQQQFIRNNINDECLMLHFNNFDFFLIFLAVKSGGYYMFEEGDTDVCDLNYKTRESLIPDPEGDEIRNIAKSKGFTAFCSKIFKGEETSEAAIVSAEITDVGESSHDSPIVSVERIKRNPDSSRPTTMTSIPDSQATDLSAMSSLTGGSSNITAGQIVQPICEDQQQQQQQQHQQLQQQQQQQQQGYEQSNKSQSDDEQEPTFMEKIRSWFDFIKTFTESIFISSTSNLNAVSRDYRFVAKRLAVEKKCLKKIIEINELEGIGHDFIGDQIWKKNTLAKLSKLTEENLENVAKSDAKDVLRVWNELDTTSLDANKHLYHVSLDPRYMETSIYIHFFRAIFYAILSRSEVICYIIIVINQITSASILSLPLPMLTFLWGSLSVPRPSKSFWVTCITYIEIVVVLKYVFQFHFWPWTELIKPSPFWWPRLLGIEKKDNYANYDLILLLVLFFHRFMLKSLGLWDLSETEIKAYMTNAELFQSRIEDINDGLSDSNPQNMNNNGKKSKNSKKKSTTNGGGGGGGGKKNKLTQKSSQEKQLEEQQQQQQSISNDVQINDPAADHHHHQPNSSAMMIATLPPPLPEQHLYENELMQQQQEDDGDEPEGDEINFIYILMEIPTRTRKRFSTIVRPVYKFFHNVLHPPYRITHDVYSLMFLCDFINFFILVFGFYAFGSGYSGSEDVARFLEENKIPIGFLITLLIQFAQIIVDRAIYLRKYIKGKLLFQIFIVIFTHLWLFFALPAMTDKAFTDKTNLPPKLWYIFKCIYLLLSAFQIRSGYPTRILGNTFCKKYNFVNWYLFKVYMLIPFVYDLRMYMDWIWTDTSLVLDEWSLMEDIFVNLYQRKCELRLDEEFPEPRGRAKKRFFKYLIGGSWVIIIIALIWGPLVLFAFGRAVGEINPPIGATFELEIGGYQPLFKMSVTDSGLVPINDQKWAKLGSSFNRDPVAQTFINGYDQQDVYIVNLNGNSTAVWGISPPSLKILQNELISNQTMLYMKITYFLTRKKTKTQDMDTTIYDEYFIELHPLKDYELRHKLADMISQSEEQNPAIIPHIFPNYLRAPEKGKPIVVTELVKKSFNAANQQTVATNKSMNFRNLLILLKKGNYENNNFSMTSWWEIHDDCQNIDYLDPFFNDMMITERCQYLPVIVFNDKVFIGLLAFLSGYGIIGIYTTFVFLVSRWVRGLNSESSFKVIYTRMPNVDRVLQLCLDIYLVRESREFELEEDLYAKLIFLYRSPETLIKWTKISEEINSGGGGGGVSNNQQQQHVDHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCF1</accession>
    <name>A0A922LCF1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_003208</name>
        <name evidence="3" type="ORF">HUG17_5213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCF1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038277053" evidence="2">
        <location>
            <begin position="24"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7642168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9529317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="517" mass="58850" checksum="5BDD66FB66313275" modified="2023-02-22" version="1">MRFGNIFIVSIIFTVILINYHDATTPIDSEYYYFHPNYFHHHPHHIYANKSNVHHSHHVIDVQKQADSNHQLQQKQQQQQQQRKYLHHNHLTEYNNKISIFFNRLRHRPTDRRLFFSFNQLLLSLVAPRLMRYQFDMMISSVLSELFRKIFVPAFTGSVKNVGGAEGSIFSSLHNLLRNNRIQQQQQPANLLPTPTSTQTNVDLQKLLDNAQKLITLQAMIRNGGQSNSIDESKKSINDDSHTELNTSSIKKKKKTGPSTSTNKQSFRSDIINNKNSHHQQSNNKNDVNQSNSNNNPISMISNLSNSHSANDFIDFIRNNLKLNQLTNSQNINNNNNSNDDDHQNISGIGPSTSDGKSGKNNIFKDFNINQMMVKSPSLSSDIGHHQSLDVGNGGDSSLPNFSSNIINKLKNFQSPSSSAVTTNDSKMKFKIFKKKAKIEDFKMSHLTFIDTEVPNYGNQLLIKDPDKDGEEDLVDSSYPLSATITMLNHLKSKPLTSSNDHDLERANRWNNVLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCP9</accession>
    <name>A0A922LCP9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_003758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymosin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCP9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.520:FF:000001">
        <property type="entry name" value="Thymosin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.520">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001152">
        <property type="entry name" value="Beta-thymosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038386">
        <property type="entry name" value="Beta-thymosin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940:SF1">
        <property type="entry name" value="CIBOULOT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20940">
        <property type="entry name" value="TETRA THYMOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01290">
        <property type="entry name" value="Thymosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00152">
        <property type="entry name" value="THY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9529902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7103" checksum="D236E9CE51A5BE14" modified="2023-02-22" version="1">MSSPTKEDLPRIADEIEQEKGQQQLLKSIETFEAEKLHHAKTEEKNPLPTKEEIEAEKKAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDB0</accession>
    <name>A0A922LDB0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDB0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22945">
        <property type="entry name" value="LEM-3_GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="163" mass="18880" checksum="CD6148434EBEDAF8" modified="2023-02-22" version="1">MKDSAKSYPRSPSKILGETLLEKRDNFFVSHLPSYNNLTRTILRAGTKRRQPRNLDELTLLPEDMNINGVQFLQKDGKNYRPVKHFLDALHESMNDTKLDAHPKAQRIRKILDSGLHPIIFTVYKGISLNQAQTREALIIDINNLTNNICCYYREKSNQNINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDG9</accession>
    <name>A0A922LDG9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">40s ribosomal protein s10-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Ribosomal 40S subunit protein S10A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RPS10</name>
        <name evidence="9" type="ORF">DERF_003131</name>
        <name evidence="8" type="ORF">HUG17_5141</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDG9"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7642096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9529240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="140" mass="16401" checksum="6583B475D2C6E344" modified="2023-02-22" version="1">MLMPKKDRIAIYEYLFKEGVMVAEKDFHFRKAHPALTKVPNLHVIRALQSLKSRGYVKEQFSWRHYYWYLTNEGINYLREYLHLPPEIVPATLKRTVKPDARTRDKLEDAPARGGAGGRESYRQNEGYRTGYGRGMKPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HFP0</accession>
    <name>A0A922HFP0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HFP0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="461" mass="50691" checksum="C8D27422020DD095" modified="2023-02-22" version="1">MLDILGTIIVIIIGSFTTIGCCAHQGNYLGDRRRLEQFLHQYQQDVHHNHQLYGHEHSIQQPKFYKVVKFVKYGDRIVPLVAIPKTQLRSKGSFQFTRPDFYNDDDDDNDDDYYSTCSSSSPSSSSTCSAMTNAASSASSGLCSSSGSSSAAQSTSTAISTSTFSSKCSSHLSGSNADNSASSSSKSASVADEAAIPNSSPPIKSKTKRKSKSSSSKRIKTSLKKLEEKNEKLLKIKNKDSSSSSSTKADDTSNNQHQSMDLKTTKPSPERINESSSLSSSTYDSNSSYSHKSMDSEITSCSTCPPSKSSSSPPPPPSSSSSSSSSSSSDKKSKYKPSKANDDKRKFSKELKLKLKTKILSQQQDDEPQQQQSNRKDKKSKSHSQKSKQMDNNETIDTIGVQTYPDEMFDAKTSSIRLNDTLDEKMGEQFYQQQKHQHGSDVNAISDYFNHDNVINHHQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HJQ0</accession>
    <name>A0A922HJQ0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_014698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HJQ0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9493974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="150" mass="17454" checksum="D5286E62D4E19937" modified="2023-02-22" version="1">MHKSKYKKIDDGQLKCAFAMFDTNHDGKLNSDEMKHMMTSIGVAVSDRMLQKIFKEASKSGDQLINEQDFLHWFSRFKTPKDDDAEADLKAAFLVFDKDKNGYITRDELKSAMLMMDESITERDLDELLKTTDHDRDGKINYEEFIKTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HK14</accession>
    <name>A0A922HK14_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HK14"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="95" mass="11322" checksum="BFCDE19AF95B14B9" modified="2023-02-22" version="1">MKTKLELSQFSKYSLNSTFQKRYYSIELGFYSTFSHFRFSNETSIPYLSNNNNSKRELFNRISLFCSSNIFPISYRYNQVLSDCLLMIIKVLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMN5</accession>
    <name>A0A922HMN5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMN5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="142" mass="16593" checksum="06B05641FE755EF3" modified="2023-02-22" version="1">MFLNQLQLLELIILNVPTPLPIYDLYRKLYQNVVQSYHQYNVDPTEKLFDFQKWVSFRNLLGSANATAVAKITIIIAKIQYFNDLAEEFLFVSVGNEFDRWHRLVNLISPSRIGCRFNSSFFVDVSYFLESQLSGQIPMVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN10</accession>
    <name>A0A922HN10_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN10"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="69" mass="7804" checksum="981751CD65A25D6E" modified="2023-02-22" version="1">MTLLSTGGWSICVRMMTDKRVVPLITPILFCLTQTTFWLAGSLIPPLDSRKWRSSSFTLDFCITSVLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN84</accession>
    <name>A0A922HN84_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GPN3</name>
        <name evidence="9" type="ORF">DERF_014611</name>
        <name evidence="8" type="ORF">HUG17_6590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7644228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN84"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7644228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9493883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="269" mass="30591" checksum="6C620AF70E9A651D" modified="2023-02-22" version="1">MPRYAQLVVGPAGSGKSTFIASMLTHAETSKRSMYAVNLDPAAEVFNYNAIADIRELIHVEDVMEDTDLNFGPNGALVYAMEYLMNNLEWLTEKLGTQEDDYVLFDTPGQIELVSHFGLMKTFAKYLESLNFRVCVVFLLDSQFISDMSKYFSSLIISLITLINLELPMVNLLTKIDKLPDDQKKALEDILEPSSDLLSEDLPCFQRNRNERFYRLSRAFAQIIDNYSLHKFLPISVLDEDLMNDVLLSIDNCIQWGEDIEVSGIDIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN95</accession>
    <name>A0A922HN95_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COX16</name>
        <name evidence="11" type="ORF">DERF_013897</name>
        <name evidence="10" type="ORF">HUG17_0782</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN95"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7645244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9497967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="124" mass="14573" checksum="72CDB7B0D07ED4B1" modified="2023-02-22" version="1">MAKSNTLLKYGVPFLSFMVLGSFLLREFTSIRYEVYNYRRRYVGTKRRDLDYVDDDEKSDEVTTTTAAANNDNETLKELIELGRNDEWKNVRGPRPWEDNREYKEMVDKVVNKKTTTATTTKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNT3</accession>
    <name>A0A922HNT3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Lsd1/2 complex PHD finger containing protein Phf2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PHF2</name>
        <name evidence="14" type="ORF">DERF_013101</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNT3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjC" evidence="13">
        <location>
            <begin position="209"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="458"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="587"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="662"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="604"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9497090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="739" mass="84273" checksum="EE48DB13A5DC19AB" modified="2023-02-22" version="1">MALCICGQGMSSNNNNKDGVVFGSSSSSITCNNCQRFIHLECANLLVHQAQETSVFYCQICRPYTGPSILKTITNHHRHNRNAENADQLPIQTGTPDFINYLKRSTSIPDARSMVDVKRMRGQQLTLKELILSGFDRPIVVETKNGLEMSMDSEFNLITACQYYSEDLIVDAIEVTRQIKVKTKLAYLLAQFKLGQDERQDVYAVRVNMSKNIKGEQFVQPRIVQRLSWVDMYWPDVPFKPLLSKYCFLSMRNAYNDFHIDVGGASAWYHIIEGEQTFYLIEPNSENLAHFEKWIKSENLHEIMFYRNVANVFKIKLTQGQTIFIPNGWIYSILTQDDTIAFGGYFLHSLNIATQLSINDFLKSLQKPGLDFPAYELTNWYAAPNILKLAKENLKNQPPKHLSMGIAALIEKLRFWLQRSKSKRSNNEQQQQQQQQLIPKAVNCSKIIRDLNRCLRKKKKINQNKNKDQIKLKSKDTIDHQQQQQSSSSQPFTLNPEETKIKDLVDTESSSNSNLKIKVNMKLAQDVIRRSMDDPYDLNSDQNVSNELLLFSKSKKKKKRQHDDELVKIIESTKREDDDYIYMDLDSPEDHQQNIDNDKIWKPGTSSTSTTTSSTAMNSNGNSSGKKYSKNSSQQSKMTTTTTTTTTMIGSSNAADIINKQQAKIEKHGQSSSSSSTTTTKLSTVETGGDIHHHHTQQQQQPPEKSSSSMAVNTMNKKYKKGLATPKQRLAKKLKMMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPU3</accession>
    <name>A0A922HPU3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxisome assembly protein (Peroxin-2), variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PEX2</name>
        <name evidence="3" type="ORF">DERF_014752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPU3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9494030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="760" mass="88173" checksum="48CA40F27326FCD8" modified="2023-02-22" version="1">MLKLVISDNKMHYYYYIPKLHVMMSMLRKLFRYFIPSFIGTYLLWYLLNPIWFNQFCIICFLSIISWTMAYYFYEMLNQETINPSGKIVLVTGCDTGFGNQIAYRLDQLGFHVYAGVLFPDGDGAQQLRQKCSKRLKILKLDVTKQEEVDNVVEQIKQSGKPLWALVNNAGIAISVPFDWGNDIDVYRKVFDVNIFGVVRATKSCMPLLRQSKGRIINVASICGRLTTTWTGHYCMAKHCVRVFSDIIRRETINSGVKVVTLEPAFFATNLTNVERLQRLREKIFDETHEEIQRVYGKNYLKYFTDTDPMIALMSHKSIDLVIDAMINGIILCHPKLYYRCGNYIDLFMFWAISHMPEILLDYLLDMAENIKNGIENCEQKQKKIKFIFFHVVVLIIKIMSMIRKLFRYFIPSFIGTYLLWYLLNPVWFNHFCIICFLSVIAWTMAYYFYEMLNQETIDPSGKIVLVTGCDTGFGNRTAYRLDQLGFHVYAGVLFPDGDGAKQLQQKCSKRLKILKMDVTKPEEVKNVVEQIKQSGKPLWALVNNAGVGVSVPFDWGNDVDIHQKVFDVNVFGLIRVTKYCMPLLRQSNGRIVNLASLAGRVRVGSLSSYCMAKHSVRVLSDCIRAELIGTGIKVVTLEPSFYKTEIINFDLMDQKRRKIYDETPEDIRESYGENYLEYLRQRNSLVQSVTKTRIDDVVDSIIDGIIREYPKLYYRCCSYQELFTMWGTSHLPEILLDYVMTKNADSLLRKTKAGPYHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPX6</accession>
    <name>A0A922HPX6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPX6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15457" checksum="71B463A47206DBC1" modified="2023-02-22" version="1">MKRRMETMEFHHHHHHHHRPTTIISTFIITIFSLIILSTIAITSIEAVIEERDNNNNKKKSKNSNIRNIVKKIRFFLSSLALVAKLTTITTTTTTIGLTISTCSSFSTKRKKNPFSHHDRLSLKIGLNSFQFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ22</accession>
    <name>A0A922HQ22_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sodium/potassium-transporting ATPase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ATP1A1_5</name>
        <name evidence="21" type="ORF">DERF_012474</name>
        <name evidence="20" type="ORF">HUG17_8907</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Derf</strain>
            <tissue evidence="21">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">JKM2019</strain>
            <tissue evidence="20">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Derf</strain>
            <tissue evidence="21">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Cell membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ22"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000038">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005775">
        <property type="entry name" value="P-type_ATPase_IIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01106">
        <property type="entry name" value="ATPase-IIC_X-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 18" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 18" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="852"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="947"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH7637803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAH9501639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1018" mass="115192" checksum="B8A342D66F719380" modified="2023-02-22" version="1">MSSIATNKNGKTESPSKLHHVNIDEHLMTINEVAARYGTDLNHGLTSEQVREKSQQNGLNQLTPPKKTPEIIKFVKLMFSGFSMLLWVGAALCIISYFITEDQETLYLGIALIVVVVITGAFAYYQESKSSAIMESFKGLIPHVAHVIRDGKLLEIDSKKIVLGDIIEVVGGNQVTADIRIIEAYGCKFDNSSITGESEPQHRTAELKQKNENPLEAENLAFFSSYCTEGRARGIAIRIGDQTVIGKIATLTHQQESQTSIGREINRFIKIITIFALFLGLNFLLLSLIMGYSFINAIIFFIGIIVANVPEGLLATVTVCLTLTAKSLSKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNKMHVSHIWFNNKVIEPLLANTMHSLKQLLSEKNRFQDFLRVTALCSKAEHENDSNHKKIYRGDASEVAFLKLLDKIGINITKIRQRHPIVHEIPFNSTNKFHITVHDISQYEPHAKHKYLICLKGAPEIVLKLCRSILLQGQCLKLETETKQDLNNVCTFFASMGERVLAFSEYYTNDYHSLLDTKDDGKTLNDKFIAETKFTLLGVMSLIDPPRPEVPDAVEKCRQAGIRVFMVTGDHPITAKAIAKQVGIISQNDENITILSDDILKEFLSNSKSNSTKQDDEQEQTIEYEEKSIVIPGWILNQFTNDQLDHLVEHYREIVFARTSPQQKLLIVDSCQRLGHIVAMTGDGVNDSPALKKANIGISMGINGSDVSKEAADMVLMDDNFASIVVGIEEGRVIFDNLKKSISYVMASNFSEIVPFIFYVLFGFPLALGTITILCIDLGTDIFPSISLAYEKAESDIMKRKPRNPKVDHLVTGKLIHRSYFQLGMIQAAAGFFTYFCVMADHGFYITQLYHLREYWDDKNYLIIDIYNQEWTYKKRKILEYTCQTSFFVSIVVCQWMDLIICKTRVNSILQQGMSNHVLNMSLIVETIIALFLVYCPGIEKILKLYPLKWWYGWFTAIPFTIYMFTYDEIRRWFIRKRPMGFFAQETCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQP8</accession>
    <name>A0A922HQP8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Wnt-activated receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">FZD5_2</name>
        <name evidence="20" type="ORF">DERF_013674</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQP8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000004">
        <property type="entry name" value="Frizzled class receptor 8a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF126">
        <property type="entry name" value="FRIZZLED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037824484" evidence="17">
        <location>
            <begin position="26"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="469"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="554"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="18">
        <location>
            <begin position="50"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="19">
        <location>
            <begin position="386"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="695"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="750"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="794"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH9497711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="821" mass="91460" checksum="750030F224A6BC19" modified="2023-02-22" version="1">MSSSTATTIIFISILFLLFESISTSISTVNQDPIHQDQSLIMVNNVVKKITIPMCMDIGYNYTSMPNLLEMETQEEAGLEVHQFWPLVEINCSDDLKFFLCSMYAPICIEEYPGHIPSCKSVCERAKKGCKPIMIQYGFPWPDKMNCSELPVYGDGHQICMDPKKGWRAGIEMDNQHMNNNNGNSPLSNNNNEVKINEDKLNHHHNNKAHNHNHQQPSNNKAKSRNNSGNNNNGNKNHHQQQQPPPPPPSTHYPPSPAPMDNNNNVMIFDTYDDNNGDNNKLSSLNREMKTSINSELSNNNCRCDCRMPYFIRLKGSQTFDDGTYINNGGNEHPHHPHHNHYHSYQQQQQSIHHFNYSKIETASGLAPMCALSCKGAYHFNENEQETAFFWIGITAAICAITCLLTVFTSLTDTERFRYPERAIIFLAACYIFIAGGYLLRIRLGHNAIACDGPFIRYQRTGPTPASCILSFILLYFFGMASAYWWLILTLTWFLAAGLKWSSEAITSYAQYFHLLAWLLPTAQSVTILCLGSIDGDPFMGVCTVGNQSRANLLIFVITPLCVCIAIGILFLFTGFVALFRIRRAIRQTQHTIRVKTDKLEKLMIRIGLSSFLYIVPEVVVVACHIYEYIYRPLWEKSITCLCTSSSRPFGSPNSSRSSGASQLLPNMGNYYGRGITGLSAINGVGGSSLPMKTQTVNLGPTTTTTTTISQPTTPHHHHHHLHNHHNQLHQHVHQQHDMQSRQASLILAPRPPSIPPPLPPPPPSLMAAMANNGHHKHHHGGGVGGGGGGSGSLTGSQFTHMIGSINGTTNSNSKHPLSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HR41</accession>
    <name>A0A922HR41_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">39s ribosomal protein l13</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">54S ribosomal protein L13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MRPL13</name>
        <name evidence="5" type="ORF">DERF_013869</name>
        <name evidence="4" type="ORF">HUG17_0806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HR41"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7645268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9497936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="182" mass="22062" checksum="876493532CD6116E" modified="2023-02-22" version="1">MSNLSPYQRVQQWMVFARQWWLFDAKQQDVFDAAQMIARYLHGRHKPIYDTEQDVGDHVVVMNAKHCSMPFDEWRYRYYFHHSHYSGGKKWTQAYELHQKDPNLIMYKAIYKACGNIGLKRHDLIAHLHIYPDENVPEHIMKNITDHIRQLRPVHKSIDEYSDDEIRNYPKIFDYSDDYTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRI0</accession>
    <name>A0A922HRI0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_012250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRI0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF235">
        <property type="entry name" value="CUTICULAR PROTEIN 73D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9501403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="197" mass="20672" checksum="35817CF10165FDF2" modified="2023-02-22" version="1">MIMIATTVALVNAAPKPQIQYSQTYGGAGALGPLSTGHFQPVSRSYVASVAPVAPIAITAAKPIVYTGSSIAPRPIAAPVAVPVAYTASAKPIRYSAPAAAIVEQEEQYPPQPFSYSYDTVDEYGTQMTRQESGDGAGTVRGSYSYRDANGMARIVNYIADHNGFRAEIQTNEPGTLTSSPADAAIVSSNPPVYKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRI9</accession>
    <name>A0A922HRI9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRI9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7854" checksum="B3143CED406C0762" modified="2023-02-22" version="1">MEIFIEISVQCKFTIPMMIDHQLAITVIEAVTFCQHDAGIRSVECIQLVWRQSSTCLRTGRFCSRCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS38</accession>
    <name>A0A922HS38_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS38"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="122" mass="14796" checksum="C90EE97BCB51E8CF" modified="2023-02-22" version="1">MFIIFRFNYWSFMSTMFIINCWLLYLFILYCQSDIYVFLATKNKYDRKYLYQSIECYVFMVSIIATSSMIMIIVEIIVLWYYRYQIGRYFPAYQFTCLFGQSRNFSSNPNSVISSNRRVSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS50</accession>
    <name>A0A922HS50_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS50"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9156" checksum="5E89234F6960884A" modified="2023-02-22" version="1">MFGGGNNSFILAQYLSKTISLSLCRYFPVMRAIVTLATYSMTRSNGGELLMAVMAMNEAVEYDFVINCTIGFNVRRSSSFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS95</accession>
    <name>A0A922HS95_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS95"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="162" mass="19229" checksum="5A8B262060BA9318" modified="2023-02-22" version="1">MVLAAVEMIAKSAIIDCTVFVSKQLRMNLNNTLIILWLGSAFVYMKIVYTHVSYLPSYNRICSRLIMNWNARTHWQRFCTQQQQKPLLQESSSSSWKKLKRFNAWITLRDVIKSNLFIQTMTNNLFGLNCGQIFFITRYKYLELLLMDVMLILLFYKKICLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HT68</accession>
    <name>A0A922HT68_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HT68"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="80" mass="9554" checksum="76A2E01DAC4A43AD" modified="2023-02-22" version="1">MHMPYYWSEYSIRLLFCDLICLALFLGFYIYVMDAKKKLLNICGFMPEHEKPTITLCTTTTIDIASQILLFQFRDRRFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUE9</accession>
    <name>A0A922HUE9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011175</name>
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    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUE9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="7104" checksum="35852178BC2B9E14" modified="2023-02-22" version="1">MNIIENDSKIRLIIWFQKSSHSLYCNQYGRYITNNGILPSACITITMIDIELQMKPRMAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUK5</accession>
    <name>A0A922HUK5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_010614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUK5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9505843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="275" mass="31430" checksum="408658D04A0171DB" modified="2023-02-22" version="1">MAAKQQFNNHYHYRSINLIVIFNFLATIISSLNSSPIDDQPKRLLRDNIQSNDIQSRLADTMTEIEWLLNQLVNLLTDMVDGIENDHTLLQDKNFRQILIQVIKRIDYILQHFENVDPSLLTMNVQNELNRIECIRIRLANYLSQSRRFDDSKCYPSTEKPSSSSSSNNDEIMPLLTQIVSLLVQISQQLYHIEKDIHGSQIGGMGYVDPSSTTTRMMTSSDGSLATMTTAANYQRSTIAEIDWDRLFNQTSATTTRPGTIFDFDQAINGDNNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUN1</accession>
    <name>A0A922HUN1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cation-transporting atpase 13a1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DERF_009300</name>
        <name evidence="18" type="ORF">HUG17_7243</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUN1"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000015">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000056">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1032"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1115"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1155"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="17">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="259"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="842"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="878"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="882"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="892"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7637037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9510794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1185" mass="133459" checksum="3AAEA8A699C53F9E" modified="2023-02-22" version="1">MTFKDLTSVRDSTDQLVQSVQCYNVKPLILQGFIGPFFTLQTILCVWYFYSDENYSDVYIITGGSLCLLQLLTFLSGMWSVHCLCFLAYSKVKNVTDAAWAKVVPTSNNGSAELVPLRHAKIDGKETIWFLFQKTKYIYDYDKQTFQLIIFPTDLPYKTYQKWHGYPNDNELQTAIKLYGKNLLDMDIPDFWTLFRERATAPFFVFQVFCVGLWCLDEFWYYSLFTLMMLVAFESILVTQQLRNMAEIRKMGNKPYEMLAYRNHKWHSILSSELIPGDIISIGRSQDDNLVPCDLILLRGSCIVDESMLTGESVPQMKEPIENLIDVGDRQFNVDTDGKLHVLYGGTKILQHTSPVKNAVSLRASDNGCIAYVLRTGFQTSQGKLLRTILYGVQRVTANNIETFGFICFLLIFAIAAASYVWNHASEDPKRNKYKLMLECALILTSVVPPELPIELSLAVNSSLTSLIKLYIFCTEPFRIPFAGKVDICCFDKTGTLTSNDLVVEGVAGLDPQNDDKIQTPQEVPIKTIQVLATCHSLVYLDDGLVGDPLEKSTLKSIDWTLTKGDSVIPRKGKQTGLKIFQRNHFSSQLKRMSVIAGYNDVTSGESSYFVSVKGAPEILKPMFSKIPDKYDNVYLEMSRKGARVLALGRKNLGNISPGQIRNFTREEVETELEFVGFLIISCPLKPDSISVMKEIISSSHYVTMITGDAPLTACHVAKELYFVSGKKPTIILNGTEKLVWKSIDEKICLPLIPDNNEFFRQYEFCVTGDSLNALLDYDPKFFIKILPKIRVFARVAPKQKEFIITSLRSLGYTTLMCGDGTNDVGALKHAHVGVALLSNPLPMPKTEKSSNNIPANNNGDYRRSINDVLAERNNSRIMNNNHHRQRRNHGHNNNSMNSASSSVNPRMIRTQERINQLLKELEEQDKSQIVKLGDASIAAPFTSKLSSIQCISHIIRQGRCTLVTTLQMFKILALNALILAYCQSVLYLDGIKFSDGQATLQGLFLTGCFLFITRSKPLEVLSKRRPLSNIFNLYTILTVLLQFAVHFLALVYLVREATAMSPPRTEKFVDLDTEFKPSLLNSTVYIISISLQVATFAVNYKGHPFMCSLAENRPLLYSILGSFGLVIVLVTGVMPEFSEQFSVVEFPQPFQTTILTVLASDLIGALFIDRICELILDRSSMKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVY9</accession>
    <name>A0A922HVY9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Growth hormone-inducible transmembrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_009217</name>
        <name evidence="6" type="ORF">HUG17_7170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVY9"/>
    <dbReference type="OrthoDB" id="6285520at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10431">
        <property type="entry name" value="GHITM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035871">
        <property type="entry name" value="GHITM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7636964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9510708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="347" mass="36990" checksum="56263746F0BD932C" modified="2023-02-22" version="1">MSIFVRNPYLFNCLRHTKFVVITTSGSPKNGTSLFQNVRFFSVGRRGTRGGTSTRSIPITKDRRSFKEILMQPTTGAPFAFGSSAVAGASLFGIGALCYYGFGLANTPGTLENAYAWPTYVRERIKSTYFYFGSGLAITAGSAIAAFRSPLVMNLVTKNSMMGILLTIGAMIGTSMVAQSIPYREGFGSKQLAWALHCGVVGAVIAPLCILGGPLMLRAALYTAGISGALSAIAYCAPNDKFLMMGGPLALGLGLVFAASMGSMFLPPTTALGASLYSISLYGGLLLFSAFLLYDTQRIVRRAETHPPYAMVPYDPVNASISIYMDVINIFVRIATILANGSGSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW28</accession>
    <name>A0A922HW28_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Surfeit locus protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SURF6</name>
        <name evidence="8" type="ORF">DERF_009276</name>
        <name evidence="7" type="ORF">HUG17_7223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW28"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029188">
        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15459">
        <property type="entry name" value="RRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14 N-terminal" evidence="6">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="102"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7637017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9510768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="310" mass="36669" checksum="CB83C41F0A0FF55D" modified="2023-02-22" version="1">MSPTCDKSTMPNKILLDEVKKLNDYFRDLINQIPAKIFFNKNEQILQTIENAKRKKFSNNSDLSNKSKHKRIKLDPSNQKSVSDVAQEFVEQKESDGKINELRKKLAKRIKELRESRTGGKNDQKTSPTIMDNDDNKSETISNKNMPKIFNKKGNLVFSKFDLTSQVDLAAEREINKDRENRKQSGKSSLQGLLLKAKKDEQKISQLQVTDSRAADRFKKEKIWQTVLEKSEGNKVRDDPQLLKKSLKKQQKMKSKRNKKWTERKESIENLKQRRQNQRQRMLEERKNKHKERRLKRFQKNRKLKNKTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWJ5</accession>
    <name>A0A922HWJ5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Arrestin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ARRDC3_1</name>
        <name evidence="5" type="ORF">DERF_009509</name>
        <name evidence="4" type="ORF">HUG17_7405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWJ5"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="184"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7637199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9511023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="322" mass="36549" checksum="70483F9E6ADB3800" modified="2023-02-22" version="1">MSYPFVSMKHHGHRSNKCSKKKQESEEMKIILEHNDIYLPGQYIRGAIVFNSVGEIPINECSVNLVCMAEVGWTDNPGIKDEGRSFHIKHKLMDVPFELSGNNGAESYYQLGHHEIPFEFYLPDNMNLPSSYQSRFGSIVYYIDVKMGEKIKRRDILVEIPIQKNLWLSVGGTSEKDFGVLSFASGRITMQATLRKKGYFRGEDLIVDYVIDNCSTATVKPRVTLFQTQIYMTGERHKTVESSLTEAVEGDEIGAHTLVDDGNLTVAIPVDIPLSIKSEYITLKYFLHLTLDIPLAIDIHINLPLTITTRAAMENTFDDRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWU3</accession>
    <name>A0A922HWU3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_009644</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWU3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A922HXC1_DERFA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011535</name>
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    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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            <taxon>Dermatophagoides</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
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                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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    <sequence length="224" mass="25817" checksum="BD4F5FA4F8773512" modified="2023-02-22" version="1">MAIRSRITKSSIVKANEQQLNNKTTKSSLIVVIKSNNNHPKSNNMIDNNNDDDDDDKSSDKNDNKSSSTTNLQQQNYRKKMMTNNNTDNELKLKLNLKKLSFEESNDNTAGIIKSKRRRQQQQNSIIRTRSMMKFDNQSSSSSTIGKTNGKTNLSFRFKVLNIHDNNEQQQQQQQTKENQSKRNIKLRLNRSQLKISPSTTTTTILNNKMMMMMDTIYGNVTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXN9</accession>
    <name>A0A922HXN9_DERFA</name>
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    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
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            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAH9511144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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            <begin position="1576"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511144.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2100" mass="235051" checksum="FA993E7F21701B8B" modified="2023-02-22" version="1">MLHTDLIHHTDDGYDDYYDDNITATTTTSLTSSLLKNTNALLQSSDNQHNQQQQQYLWITYGWLAICIVTIIVIVLIIWTTLIHYTYRKKWRTLDILLAAILIQELPNAITLLSISTIKSTLIHLPRSSSFVNSSHQHDYHSNWNVYDILLWLSTSQRFFQFAIITSLIVDRAFIIKWPYQYRFSVRHSQIRFYMIILALISAVFGTFAVISHQNYQFDRSKLSMATTKQQQQQQNLTVTTETTTIIDDNSTTESSLNGTISIVTKPPPPMNQTSYYDDSMIQFSYNPMIYDIYYSYFFITIYIVLTLICFGAFLYVELNRPKTTTISTTKNSSSTSKNLQSISTLFATTSTSTSSSTSSSLSTSSPSPSRFSSFANLTNSNNNNNHTGHQSNNNVSAAAAAAVNHQSSIKTSSILPSYYYFPNVKHHDQQQQQQLKQIMVANHSLKITDIDDGDTFDNSNKSIHHQQQQQQQYGDSSMISLMMIANNGDVLHHDNHQQMTDVNINSLGGNGGISVIRASTTPTPTATTNGTSSTYASMMTTATDNNSTHRLIDNANVSTNQQQQQHHHQQQQQQSNASRSNSINFNFEQKCAINTLLCSNNNNKNLIGSSTNGGCPSLDVTAAADSYSFLKQSFNLHGLSFIGNNNKSGSQLKLNDDSFVDHHHHHHNHHHHQQHQRIQNSAFDLRWSSVIGPVSFCFAFNHGPFLVFNLLAIFIPGLWTPFHDLILVALSLFEALLLPLIIFISNETFRDAFTRSCCHCHSSSSHHHHHHHNRHRPHHHHHHHSFIHDKISSICSSNKSSLTFTVTSNATATTTNDISTVERNAIQSQMQPPALYPVSSSNTSSKTSSSTSSSSSAASTSSADKKQQTTRINSFLTSYHSDLDLVKKYSKNDQSTNKLNACNGGGGGGKITFQKYSHNNGDMNRHKLNHATSMLDLSLTLTSQQQQQQQSNNYDPLLLLTPKLSSFNQRRQQQQQQRPPSVASCHYLFSSNQSANQSQQQQQQQSKYGRYYGQFMFGASSSSILMPKSESTLSVPLNVSSSGSFNNNRFDSSSTPYKKEFIAVGDGNGNSNNNNKLFNHGKCSPISININQFDSSTAAAIAINNMPISNNNDVDDDDDEITTDIGYNNNNENDDDDCHNEKINEQSKSVRKSTTKLIDNIIQGITGRSRCSSIRKSDSDASTFYNRVHNNNMKRSQIARNQLSNILYNNFYNKKLSPSAFGSEIILLSENEHGKHCVKSSSNKQKQQQQQQSGQFPRPHVYLPSVSSSSSLLLQESNTSRSNSCQQIAILNGENTDHYHNHLLLKKQNLSSSLMLDESSPLIGNDEQLQQQQQQQHQQPYNGENHIIRNGDFNNKNNLIMDDEPIYASLPNDEQDEEEEHEKHDDDDDDDDEIKASGSFSARSTLPDDCQLISVYAHAGNHGDEQQQQQQKSNILQINSSNVNGKNIRNLNLKCFPDTDNDNNGDNGNSNSSSHTTTSSSTSTVDESSEDIYEEVGHLVARSSVIRPNDDGELNNFDSSNNKRQRSASQDTLIEQNNNDPFDDSEQSNVSNLNANHSNNNISDDDQTSLHTANDDDDDDDEDLDEDQISILSETSSSTFSSFTTCANQDFEFIVSQQQHLTDMTTATTTTPATTKQTSMESSNISQNQNIKSAIKSNATNQLALRYLKSDLENFLIEKPSSSSSSSLEPSTLSMAAMYYNRLILDSDSNRKNAKKSGHRQRSKLNRRQSFSTAHELRQRILYNQVNNNNKNDHETNKMGLIEEEEIENHHHNNDNGSINEYSMFQTTNFNEMNFPFNKLDRRISSSEDNLLSIISTIANCGDDDDYDNNQELLLESPNKIPCTNVEKDNFAQISNDANITSSNGTFVLKKDVNQRNNKSAIPRATSNSNNVIGATAVGGFSSNETLKITIKELKSKKQAQKRSTTTTNNLNSNLKSKSSLMANCNNRIYELGSLWERQSSSSSSSSSSKYGKESLIKSSSNISSSSSESKVKQDFNQNKFKSTKTTTTSPSSSSSRVSTFITVSPSPLRQQQQPKKPQTNFTSKLLPPSDYVVKQQQQQQQPKQDARQNAILAKNALLMSGIQRTPINKLPLQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYP5</accession>
    <name>A0A922HYP5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYP5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="76" mass="8773" checksum="A625B4F9D4484A90" modified="2023-02-22" version="1">MITLVFYSYSVVGWLVGWLVGRYQVYQSSSSSSFYIGNCLFAQRDLTTFNIKNIFMKKKMAIFVLVSDKFPSLISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0N6</accession>
    <name>A0A922I0N6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TAL1</name>
        <name evidence="6" type="ORF">DERF_008577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0N6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040238">
        <property type="entry name" value="TAL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864:SF15">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA PROTEIN 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="133"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="67"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9517971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="445" mass="49765" checksum="360D8043F1978C0C" modified="2023-02-22" version="1">MMDADSSTAEFGLKSKKKHHHHHNNSLMIKIEPRSTAITLATQQQQQQQLLLMDGTLNIMDSNTSNIQTTTTTTMNDDTKSGQTNQVSTTTGLLPNEMKSNQLSSNRSNNRSQTTTTTTNASSPSSKSRSLSNTRERWSNNLKSRQQNVNGAFGELRKLVPTYPPDKKLSKNEILRLAIKYIRLLSNVLEYQKQQQQQDEQEDDDENNHEIDIDTSIIINNHNSLSLSSSSSTSSSLSSSPSSSLSSLPYTNSNKNNHHQSIFNGYANDNLINLKNQIYFPDFRHQSPIPLSLLSNGMIMNNINVTALNNHHYNHRCFTIKYDTNEIISSKNNDDKIRILKRSSSSSSTTSSLIRNVNGKNNKRMKQNKQESKMEKKISLFDDNDNIQMQKPSAAAAAAATGAAVMTIHDCNEELFHSSSTTTSSSSSIFFSDSEEHDDDDDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0U3</accession>
    <name>A0A922I0U3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene synthase</fullName>
            <ecNumber evidence="2">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0U3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="381" mass="44702" checksum="CE50F662BE31E4A4" modified="2023-02-22" version="1">MPQPSNVEYYDQLDRLNFIYPHYESPFPVVINPNYSQWMIRYCYEWAIDNSGPLRKHQAFVDSIRNSDLGLYSACCFPSANFHRLEKLMKWCTMFFLADDYHDGLSRILSNGQIDYGNFWHQMIDMFDGILTGYQLNYIAGNILEDEWTTNDNNDHMSNGNGTNETIIPNWDSYMKARLGSVGGQMTLQLIEYAKNIALTDQEWNHPLMKSLIDAVSEEMIMVNDHLTFRKEVAEANFKFSRMRHAYTVLVHTKGFTLQEAVNHVHQLIQEKDTFIFDLIDQIMLDPVLNSSTEASERLRLYLEGVKEVLGGYWRYAVQARRYHGQNFQLDAIPPGGHFLYDQHQTIILLNNKNKLNNHQHQQQQHYYEWLKPVPENVQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1C4</accession>
    <name>A0A922I1C4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cuticle protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_008906</name>
        <name evidence="5" type="ORF">HUG17_4748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1C4"/>
    <dbReference type="OrthoDB" id="8021718at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276940" description="Cuticle protein 14" evidence="4">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7641703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9518316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="19429" checksum="5E5ABEAF4D7665C9" modified="2023-02-22" version="1">MKFFIVFATLVAAASAVPYATHGGIVNTGASAVSRSDDGYGNYAFGYNEDHATGGTFRKEKGGPGYQTGSYGLRDADGRMRVVNYVADAHGFRASVQTNEPGTDPKQDPAATSLTGGHAGVIAGPAIAAAPIAHAAPLMAAPIAHAAPIAHGLPIASSYSVSTQHASIAAPMHAAPLAGYGYAKAGYGLGGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1G6</accession>
    <name>A0A922I1G6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 234</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_007616</name>
        <name evidence="7" type="ORF">HUG17_1981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1G6"/>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7646443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9516902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="134" mass="15143" checksum="56A7205FD9382C17" modified="2023-02-22" version="1">MFNDRSFGYLLTMMSGILWGLSTPFMKQHSGHLAWNVRSSQNILSNVWPIIKMLSSNWKFITFFFINQLGSILYTYSLSYTPINVAVPFSNSINLTLVVLFGCFKENIIINTEIIIGLFLVITGITLCTLSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2L0</accession>
    <name>A0A922I2L0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2L0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="77" mass="8534" checksum="58A501510BA777C5" modified="2023-02-22" version="1">MAPFILVSIAIRFLFWKSNQIEWIGFKIFVNKRELNFIFSADNETKTKHPPPLSSLPLPPMKISSVSSSISGGIGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3B7</accession>
    <name>A0A922I3B7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PDK2_1</name>
        <name evidence="14" type="ORF">DERF_008481</name>
        <name evidence="13" type="ORF">HUG17_2599</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3B7"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000007">
        <property type="entry name" value="Mitochondrial pyruvate dehydrogenase kinase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="236"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7638566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9517862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="408" mass="46337" checksum="8BD204B891EE0357" modified="2023-02-22" version="1">MRITRILYREVLKQVDYYSRFNPSPLSIEKFLQFGQEKCEKTSFLFLRKELPVRIANIMKELHLLPNSLLEMPSVELVKSWYERSFDEILNFENASSDSAQVLELFCDTLVKIRNRHSNVVETMAQGIIELKQSSSVDQHLEHCIQYFLNRFYMSRISIRMLINQHAALFGSDLHNQSPRNIGCIDPNCDVKAIAYDAYDNARFLCDQYYLTSPGIDIETLNASDPDGPVTIVYTPSHLYHILFELYKNAMRAVVESHHEDDDLPAIKTIIVKAKEDLTIKICDKGGGIPRSSRDMLFQYMYSTAPQPSASGMNSAPLAGYGYGLPISRLYARYLQGDLVISSLEGYGTDAIIYLKVLSSEANELLPVFNKTSSKHYTSIQGTHDWSSGSTNNTNGNGKWNDRMSVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3T8</accession>
    <name>A0A922I3T8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Glutamate receptor delta-1 subunit -like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Glutamate receptor ionotropic, kainate 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GRIK4_1</name>
        <name evidence="15" type="ORF">DERF_005337</name>
        <name evidence="14" type="ORF">HUG17_3625</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3T8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="13">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7639592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9521704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="428" mass="50141" checksum="11084F974902F90E" modified="2023-02-22" version="1">MKSLLLNRTLTIAYSNTLPYTGINHDHHHIGIEYELLKTLANIFQFKMIFIDCENDYGIRQSDGNWTGMMGKIFNHEADIAIGGIVVTYDRILSMPFLYPHWIDSLTFSTTIPHKRVPLGLFFQPFTPIVWLCLFISLILFPVLNLCYQHPPYDNYAYNLFWINLCLLLRQPYNGLRSRLNLSSKMTTIIWMISLIMLANIYSSYLCSKFTIPDYNMIDTTDKLADECDDNRITPMLTMKTMVYSLFKTDSSIRTIRSVARILRGIMDQSEGERLIIDQTQKERYALISSYDRIKFSELKFGPKSFYLPSPSGDSSFFPLIVSFPVRLPNDYIEPFEIWIMRITSSGLMECWKNRLTIATRQSLIMNRNIKHFNSQMDKNINTNTNKDFNLNHFERLVQLFLLCIITSFIIFMNEIFVYRLKILIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3Y2</accession>
    <name>A0A922I3Y2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_008680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May increase the toxicity of alpha-latrotoxin and/or other venom components. Is non-toxic to mice and to the cockroach Periplaneta americana.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3Y2"/>
    <dbReference type="OrthoDB" id="6365952at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2010.10">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018251">
        <property type="entry name" value="Crust_neurhormone_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031098">
        <property type="entry name" value="Crust_neurohorm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035957">
        <property type="entry name" value="Crust_neurohorm_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001166">
        <property type="entry name" value="Hyperglycemic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35981:SF2">
        <property type="entry name" value="ION TRANSPORT PEPTIDE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01147">
        <property type="entry name" value="Crust_neurohorm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00550">
        <property type="entry name" value="HYPRGLYCEMIC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81778">
        <property type="entry name" value="Crustacean CHH/MIH/GIH neurohormone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01250">
        <property type="entry name" value="CHH_MIH_GIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR631098-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9518078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="106" mass="12204" checksum="5C2FBBBAF6A63893" modified="2023-02-22" version="1">MNKSAITKRIGTLLVSFLLFMAAFVINSSESRSFTLLGCLGEYDISKFTELDRICEECYILYREPELNISCRKDCFRNEVFGNCVDALKLSHEKKKLLEFVDQVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4H5</accession>
    <name>A0A922I4H5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tropomodulin-1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Tropomodulin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TMOD1</name>
        <name evidence="6" type="ORF">DERF_004808</name>
        <name evidence="5" type="ORF">HUG17_7757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4H5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051694">
        <property type="term" value="P:pointed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000099">
        <property type="entry name" value="Tropomodulin, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004934">
        <property type="entry name" value="TMOD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901">
        <property type="entry name" value="TROPOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10901:SF6">
        <property type="entry name" value="TROPOMODULIN, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03250">
        <property type="entry name" value="Tropomodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7640290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9521135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="424" mass="47773" checksum="E636A541839886E7" modified="2023-02-22" version="1">MSEHKSKTFPAMMPQQPTPQSNTSSFTMMTSPPSMPPPPSLSEITKTTRTINQRRLSERKSSQELFQQPKLKMLYGKDLKEYDNLNVEDLLGQLSAEELEQLSSEVDPDDSLLPPSQRCKDQTNKDPTGPLKRRQLLNFLTKFAKEQEDWPEIKKFVPGVKLGKVWVPKQGDPKGGMEEKIILDLEDGAEEALGNATEADLVDLAGILGLHSMLNQDQYEASILNKGQPLGDKFESIVKSTKPKKILPPEPDNMTDPEKTAKQVAENDPNLTNLNWNNIKYIPRETFKKLFNGLKTNTNLIELNLSNTGLTDGPAEKLMEALKVNESLRKVNLESNYLSGPMIRDLIEALLDKQNIVEFRAANQRPQIMGNRYEMEIAKLIQQNKTLLKLGLNFDVPDARHKVATQLQLNNDSCRLKRLASVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5F2</accession>
    <name>A0A922I5F2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein tweety homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TTYH2</name>
        <name evidence="15" type="ORF">DERF_008886</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Probable chloride channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the tweety family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5F2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005229">
        <property type="term" value="F:intracellularly calcium-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072320">
        <property type="term" value="F:volume-sensitive chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006990">
        <property type="entry name" value="Tweety"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424:SF8">
        <property type="entry name" value="PROTEIN TWEETY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12424">
        <property type="entry name" value="TWEETY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04906">
        <property type="entry name" value="Tweety"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 13" id="KW-0868">Chloride</keyword>
    <keyword evidence="9 13" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="661"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="661"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9518296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="751" mass="84128" checksum="3723C91758605148" modified="2023-02-22" version="1">MSSTQQHQQQMQSQSVSEMYFVTVAKIEEFLENLTIMITNQLSLNDPSLTVTTHESLYNMSIVAEWFHSIPHVDIKLRPLPANITFDPNDNEYLESLGILVAIPGFWLILTLIFFLIFFLCRCCDGPNSGSKQQQKQFHQQATLVSKTPKPKRLTGCKICLALLAIIAGLAITISLLGSIIVHRGMVQLGNSTADIANVIETVQNDTRTAAYYLHDEIDVNIESLKGAVEKMLVKDVAVKANLENQVFFLKRNVSRCMRRVDDIYSRIEKLNIRPVPDTVQFIEKIRWPSTFAFAFYLIIFCLILLCGLVRHSRCTLIMFSVFGLLALVLGWVLSSLYLGLLVAGSDFCAEPDAFLDDRFSNEAEMAILDYYIRCRLPTHQQQQPIGSNHPFRVQTRASLIALEHMSELIRALEMLCISYCSPDQSVVRPQINSIVQHLNSTERLLKSVQALLDCRRIHDDFVHSMSATCKDLIEGFFLLLVTSSAIGLLFTLLVLCASHTWIHIRSVQSNSTTSLISAGQAGSSTLLGQLDNADETDPFLPPTPRNILTSQHPHHTILSNNSTSSSLTNASLSGKRFRDSYSSAYGTTGRGRFSHTPPQTPHFTTLGGGEGGVMTTTTTINPVHQHSQSTLTHHGTIGRIVPRSEEQLAFLSPPPAYDQLNQQQLQQQQQQQQQQQQHHQHQQQQQQLHYHHQHQLYGTHHTGTLPHTHHHHHSHLPATSSTATQHQAPTIGHHPSAIGHYMVSADTFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5Y7</accession>
    <name>A0A922I5Y7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5Y7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="404" mass="47062" checksum="F23FB9BD6FC10857" modified="2023-02-22" version="1">MTKEEEQKSKTVAVIKMSESEAEQQQKQPIVVVGDNSGFPKLCCKTTEISGLSSHYNPHHKQQLQRPPTMVKQSFSNYHHHDDHKTMVARNNSNLLPLNLWTTKIAPICKSRLISKLEKTPPKEAVKSLPNSPSGNSRREFERRFKETLEKLDHFKDDDDDKDEHDYDPQDQYEKLRPMWKGKESEKQWKFVPRYYNDIMDDGKDDEPDNDDNDDDQEAWLKDLVRLVMHSSTDQQPKAQPIVWLRSSQPKSANKSLLKQTKSAPKIIITPIQGEGKMMNFDRQTTTTNPNLTTAVIRGTFSRASTLTAMVVSSNQNNDNNNLANQSSRLMNKGQWSPMNQALPLNNAYNLIADFFRRSSPSRRRRRRQQRQQKQQQQPNDGIPMDRKQQRNNYRGNYRRFNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I620</accession>
    <name>A0A922I620_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myotrophin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_006341</name>
        <name evidence="9" type="ORF">HUG17_2934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I620"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000812">
        <property type="term" value="P:regulation of barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF69">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="5" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="7" id="KW-1053">Target membrane</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7638901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9522781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="122" mass="13501" checksum="49138595E926DBBF" modified="2023-02-22" version="1">MVIDTSKLVWSIKNGDFDSVKEIIEHEKLDVNSMIDGRRPIHYAADYGQKEIIEYLIQLGANVNSLDKHGISALLAAIWEGHIECCRLLISNGAKIDGRTPDGMSYIDAAENAEIKSLLMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I622</accession>
    <name>A0A922I622_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ATG4C</name>
        <name evidence="13" type="ORF">DERF_004984</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I622"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF52">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11 13" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="12">
        <location>
            <begin position="58"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9521316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="415" mass="48260" checksum="7BC1511C8778E2C4" modified="2023-02-22" version="1">MWNTVKYGKFSCNEFNHRFRNKFNFNSPICVLGQLYYGKMSDSISQSDEQSSNLYAYDKFKKDFYSRIWLTYRRDFPPLLQTPITTDNGWGCMIRSGQMIMAQAFLTHFHGRNWRWEGQDDLIHRMIIKWFADIPDRSTSPFSIHEIIRQGQQLFGKNPGDWFGPASISIIMKNLLEDAAKDNRLLCDICCYIAQDCTVYLQDVIDLCRTANIRSNSNTIIDDDDGNNQWRSIIILIPVRLGGDEFNKFYSPYFKQILSLSSCLGVIGGKPRHSLYFIGFQDDKLLAIDPHYCQKSIDVGTRTNFPLDSYHCISPKRISLTSIDPSCTIGFYLKTKQDYDEFINFSQQIIDHSYKSNGYPIYSLDSNNRFDNQMNEPLSSTTTTTMDRILRMEYRLVDRHGNVQKLLSSEDFVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7W1</accession>
    <name>A0A922I7W1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Triple functional domain protein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_006497</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000023">
        <property type="entry name" value="Kalirin RhoGEF kinase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058918">
        <property type="entry name" value="KALRN/TRIO-like_spectrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051336">
        <property type="entry name" value="RhoGEF_Guanine_NuclExch_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826">
        <property type="entry name" value="RHO GUANINE EXCHANGE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22826:SF106">
        <property type="entry name" value="TRIO, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23323">
        <property type="entry name" value="Spectrin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="1396"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1591"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1718"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1896"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2056"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2179"/>
            <end position="2202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1718"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1747"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1778"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1896"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1912"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1963"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2006"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2061"/>
            <end position="2076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9522943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2202" mass="253535" checksum="78A88AE88892DCDC" modified="2023-02-22" version="1">MDNWNLDCPIDSNDSYECRNILECFRKQTIKAYDIKSLLEERYAILSGGRDIRGGPIIFFPSRQPSSEKFNIENLKIILNYFASIPSDESKALEFCVIIDMRGSTWSTVKPILKVLDENFPVKIHTTYIIKPDNFWQKQRTSLGTTKYKFETVLISVESLAKYIQLNQLTNDVENGSYPYDHINWIQSRIVIEQFMERIAKVYCIMLGMKEELKKITFSNDSQVINSIIEEHKMMKKKISEIPVDDVDLEVQQLLAKLSYFMHDTNMIHLKQSYSRELIINKFFNPDIETAIARIFQIVNEIHHCRQNLLRLWNQKRVKYEQHLQLLLYESDANKMLEWLRNNKEIFMRSFIIIGTTLADIKELQEKHGEFANASVNVYVNITKLQHVASNMIENGHTSVQLIQQITGQLDRSWKEFASILDQRNLLLSIALAFYNNVEEYTQQLQNFSTFCDNHQNLLQQSSSSSTTTTTTTTNISPSSPAYHQQQQKVNELESLVKKMQSFYEKIVYLYNECHSSSKKLITQLEHLYKKYSGDIASHHHHHHHHHLPHQDSNTFLHQFYRDYNDSMTNIMSLLQTLVMNQQNIDSKWHYLKIKLHQRLALALFQDDVRQVLDWINVHGNGFLNKNPGIGKNYAKAKILQKSHIHFETVAQNTYTNAEKLLAAADELARTGECNADEISDVARQLQSHISTFAKRVENRRTILNLAVAFYTLEKDINNYVSELRNQVNGTPLDMPENKDLIEKIINNYLMQRKSVHTLITNAIGKGQLLLNELKNYSTFHQENYDYSEESFHSLSSSITTIQTSCDKLKCLVQEFEDLWNSQQYKHEICLKIRLFETDSINITSQVDVWIENIQSAIYMDESKQQQQQQQSQQMQQLTLADLQQYESKLAATNEKFTQLQSIIFESVHYGKELDQLLESCPFRLIVNKGGNNNEQTGHDLVKKITTFLNEKIIDLEDIYEVRRKQLEQMIQFGHFQLNAEQIFIWIRNGDSMLKSSFYIPTSLKTAENLRSDHEQFQDAIEKTHCRAIYLHQKADSLIQCGHYNCSAIEQISNELSKRWQNLMTHAEDRHKLVLASINFFKTIEQVCSVVSSLQNEYKHDEDFCGASRLTVITPETIRNLDNNDEYALSCQISKHHEQKEAFLKACTHARRNAENFLKYIQRCIQYYSANYPNQTYTNAENRIKTIMDDLLTQENRVLEYWAEKKKRLDHCKQYILVEHSSKQALKWINENGLTFIQTKQSYLDDQNQQQSFDREKLESLCIEFNNFNHYLGECREKVSLLSQLSQNLIQKRHTHEVAIKKWVQFVEQSYKDFYKQLDLFKQRLNEKQTLFNIESAAASASASSATAATMIIKDPSPSISANQQSSTPTTNLVKDIISSASSSTSGGNVRRSIRKKDYIMEELLRTERTYVEDLKLCIDTYLREFRLAGDNHLPPFLQGKERLLFGNIEQIHDFHKRVFLRELEKYEQIPEDVGHCFVTWSSSFDIYVEYCKNKPDSNLLLVQYQGSFFDEIKQRYSILHPIDAYLIKPVQRITKYQLLLKDLLSCSDPGQEGEIKDGLDVMLNVPKKANDAMHFSMLEGYDVTMDQLGEVLLQDVMTVFDSKSLFKKGRERRLFLFEKLLIFSKEIRDSSGKSKYLYKNKLMANEININETLDDSELKFSIWTGKLSSMSDYKITLKASTLETKQNWIRKLNQLKTDTFLYSTFFKSKSNQQKLLNSTSSSSINNNHNNRSSRDFNTDDDECLNVVSNSISTNGSNSDTHHHQKHQPLPSSSSSSTTMTDENTSLISTTSSGYKTDTSDKTIHDYAWIKEDFSEQKISSYDHQRQQWPFLSVRIGQKVEIIEQRIHSSPTTHLGDFCLVKTIQNELNDNHHQHQQLQEGLVPINILRFPLQKQQSLSSTSSSSINHQLQQPQQRPSIMSTMTTAQPTFESSSQSPTTTGEADSSTSVLFHDHQHQQRQQQMNHSTTTTVTMAESNSNTSGGGASGQNKKRGVLKWITNPVRKLSQGSNKQQQQPVDKSAINHHNNDNDNKPTTTMSTLSNTNNVTIITHSPTANNKQILPLSPNSSSSSSSLSSTMIPTNQNEILIDPTVSTTMIVVNTTIASNTNDDNNHVNNASPAIISDINVIGGGGGGGTGEEDCDLTEIEIPPPMAVIQEHNYQTIMSSSQAAQDSTVMTIDNEQPSLPATKQQQQQGSNASLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I884</accession>
    <name>A0A922I884_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Coiled-coil domain-containing protein 186-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_005446</name>
        <name evidence="3" type="ORF">HUG17_3552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I884"/>
    <dbReference type="OrthoDB" id="5583482at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099518">
        <property type="term" value="P:vesicle cytoskeletal trafficking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038830">
        <property type="entry name" value="CCDC186"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18911">
        <property type="entry name" value="CTCL TUMOR ANTIGEN HD-CL-01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="463"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="679"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7639519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9521819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="82347" checksum="9F52F5328842B264" modified="2023-02-22" version="1">MSQPVNDDDDDKQLNDHSSDQQQQNGDSSTIHAPSDDHQKSNAKQINAQELMAEKLEKLSVDNDRLNRDNEELSTKITELDRMVQNYRQKSIASNRQIEQIKSELQSMVIKYATSEKEVIDVKKRFDDIDRKYRDLLKERDQLQLKTKELSQEKKQLLQSLERQILESASLRNRNEILVNKLEQSQVQTQQLQLSFDDISAKYNSSSSKLLEIESALETLNLVDDSVVLNSDGDEQEPHTKKQQNKWIDVYLQCTHSNHKLNDKIVDLETQITHYREEIDQLNEQLAKSREQLKNFQQNLNLIESLKQELIKQQDVINDLKKKFDKVNEMNRELLNEADSSKHKESELLEYTERLTAKMVSLQCEHNSLQEKVRSLQCESDRYHCDYDRIVNERDQLEQRLQSTIDKQSLQIQQLHAQIEEKNVDAQNLRKRIEELENDINIMKRKHILNLKELNKEIQQLRRSQQKQPLLLDAPSTTSIKTTMSETATNSSSLSSRTNSLSSLNEMIYSRTQLQSNNDNEPNTDTIGNGSSSTNCNSDQLSIDTSQISSSSSSTTTNHELTSLNDIDKNTLIERILRLQRQLIKRNEKIDFLEEHNGQLIGEMKKKSKLLQYYILKEETGALATESMDKNKAYISKRGGGIMSSLYNSSLTDDTMTLERSLEINNKLHAILEDTLLKNMTLKENLNTLALEIDRLSKQLQQQQQQQQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8G0</accession>
    <name>A0A922I8G0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell cycle checkpoint control protein rad9a-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Cell cycle checkpoint control protein rad9b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RAD9B_2</name>
        <name evidence="2" type="ORF">DERF_005552</name>
        <name evidence="1" type="ORF">HUG17_3470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8G0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7639437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="513" mass="59205" checksum="0988F5D745F84EF3" modified="2023-02-22" version="1">MFSRNIEPQSGLLNGTSLFDIWMAKIFMTTKLANPKAYSQASRFRNPSNDIEWSQLKLRDFDYIQIYIHLLIILLEFDYKLNVIIMKSTVIGLNLRTLSKTIRLMAKYSEEIKILVINDCLILQSVNFDSTLFCQVTFEKNFFTSFQNDDDFECKVDIRSIGFVFRVVSLDKMTNVCKIKMDNSMDHIIFHMECPNRIRRNYRIPIMKNNDHQRCPVPLSQQLSNPTLRCSAYTMNESIKPFPLSTDEIIIWTFRDYLGFKTYFETNYDGPMTEFCVSSTYFRMMDSVYNYTNDMSIALNLKELRSFLDFAMHRNQVISAYLQSDGKPIEFMFKNSDGCSASIMMGTIDLKNDSQPAIPPAFRITHQITDDSSSGSVLQNVSLDSRAISHEIPMNHSSMGKESIHHDVSTFIGNVTNSSLPNQSIGQQQLSLLDQREQSMDTASDHPIRDEFIPQNIDQNDDDNNIDISKEIYQEIENSDNELTSSQSHFVFGDQSFEPYATLAPYSEYEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8Q3</accession>
    <name>A0A922I8Q3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uridine phosphorylase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">UPP2</name>
        <name evidence="4" type="ORF">DERF_000359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8Q3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17763">
        <property type="entry name" value="UP_hUPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010059">
        <property type="entry name" value="Uridine_phosphorylase_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01719">
        <property type="entry name" value="euk_UDPppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF11">
        <property type="entry name" value="FI09636P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691">
        <property type="entry name" value="URIDINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="70"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="152"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610059-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9526258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="339" mass="38666" checksum="54C4D57EA187683D" modified="2023-02-22" version="1">MDHSTNDGCVDDHDEYNVEIVYDNFQMKKSQDGRLHLSNKHLTNLQSDTLYHLALNTSTHNFEQMFGDIKFVCMGGTKKRMYEFAQLATKELNIMESKLVDITESSHRFSMFKIGPILSISHGMGISSISILLHEILKLLHYAKCTNVTLFRIGTSGGIGVEPGTVVITNKVVDELLRPFHELHILGKIVRRPATFDQKLIEELGQIARLQNNPGYKTIIGTTMCAMDFYESQSRIDGAICNHNLDDKMDRLTKLKKAGIINIEMEALAFGSMCRYVNVDAAIICVTMVNRLDGDQIQLTKQEYHELQKRPQKLAIDFIKKRLAIIDNNNNYHHHHHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I948</accession>
    <name>A0A922I948_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Motile sperm domain containing 2-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Motile sperm domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MOSPD2_5</name>
        <name evidence="3" type="ORF">DERF_005856</name>
        <name evidence="2" type="ORF">HUG17_3222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I948"/>
    <dbReference type="OrthoDB" id="6504392at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053012">
        <property type="entry name" value="ER-organelle_contact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46384:SF1">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="88"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7639189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9522269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="277" mass="32661" checksum="ABD0435AD7E58704" modified="2023-02-22" version="1">MPLPPPSEAILKKIERLRARFEKELETNSHLYHPIDIERVRTEEWQVERFAADDIYELDNDDGPFKAMCEALQWKKTLNVHERTEKSFPKEFYELIEVEINGRDNEGHLIQWEATRNQRKFKELEVLTREFMAFSLERLDRAAGRDGFVYVTDNGGAGLANVDMDMNKFKISAIEHYPGGMRKMYVVDLPWLLNGIMSMILAFMSPRLRALVHYCKKTDLPKFMDVKHISLRLNGTRDKHAYPSDTRRLEEMTELGLDEKFLDSFYKTYKLKRTMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9E9</accession>
    <name>A0A922I9E9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000762</name>
        <name evidence="2" type="ORF">HUG17_8502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7641033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9E9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276954" evidence="1">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="173" mass="19835" checksum="3A13755939D3493B" modified="2023-02-22" version="1">MAFNRFYWIFIGLLSMIMCSWSSTSLGASLSPSSSAAVDDSFIQILDGKHEMDFDLRNNDYGMNLIESSACQLLLSESNGRKSLFFMKRPNNNGQRLQSSMAKLQSYCRCLVGCLFDYIDFPQYYSDDIVQSQLEFARCGLNCLHYFFHQANNHNSNNNLVRLFYNSHSNFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9I0</accession>
    <name>A0A922I9I0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ras GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RASA1</name>
        <name evidence="12" type="ORF">DERF_000804</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9I0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11788">
        <property type="entry name" value="SH3_RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035652">
        <property type="entry name" value="RasGAP_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF146">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="158"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="255"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="7">
        <location>
            <begin position="327"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="455"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="607"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="11">
        <location>
            <begin position="778"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1031"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1032"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9526742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1112" mass="124911" checksum="BABDE2F478BFA099" modified="2023-02-22" version="1">MDIVKRSSSACPQSSNQQQQPPMSSSSSRHLTSSNTAAGSEFPFQNSSDVFTMISPSQSNSSPTHQYVKPPAPLPPPLLLQQQRQQKCLSSFLNDAFANSSTHSQPQSPGPCSSLAASTSITGFSSASGSCSANGSSFMNGFDPIQNLAEVAPCRSQWYHGRLDRKSSEARLIRSTLQSYLIRESDRKPGSYVLSFFGNTGINHFRITAICGDYYFGGKQFSSLEELIGFYTVCSDLLKNERLVNPVPPPEPIRNKERRVVAILPYTKMHETDELSFRKGDIFIVHNEMSDRWLWCTNLRNQESGLVFADLVEQVDDDTDPNEVYGWFHSRITKEEAFEKLARSGPGSFLVRPSDNSPGDYSIFFHVDNSVQRFRIERHGDKYVMGGRVFPTLEAVIQRYKEEQIVEGHRLLKPVIKAPYETRWSTSRAEQLRSTAADIYATIRECREMAQSCQDGKKRGYLLKKSNKTKKWKNLYCVLNAKEAMLYFYDSPKRARPKSIVHLSYSALYMVHDSLFDRSNCFQLVERTLPCISTIYYLSAADSDQAQEWMQAIRPQCSPNLSAVNSRIFRAVHEDPHFGTAAFNGAAAVAATLDESVSPTRKAGSGSTNGSSPAASAKGVSRLRSLYITMIEAHRLPVKITPHPFVVISLNTVKVARTSVKCPPDPIWEEDFFLEDIPADVTYFKLVLLNKGKRSKDSELAEINVELSRFQSGEEFEEWLHFSGLTLPIRDDWGSVRVRVRFVNELIMPLAEYSPLKDLLLGDDLEVIAMCEKLCYHDRSTLAAALLKISRYQRRECHLIQALLEREIQLETDVSCLFRPNSLTTTLIDQYMKATCQEFLVKSLTEPINKVFDSKASCELNPAKLDSPSEACSNAENLLNILDEIVEVIFSNAHHCPLTVRYICASIKMAVSLKWPNDQLVRTRAVSAFLFLRLICPAILNPRQFGLISEMPSETALRTLILVAKSLQNLANLVEFGTKSIFITPDRFEPPPPPNAKREPWMEVVNPFILKNKSRMIKYIDEVASSPYCSSNNNNNNNNNNNNGGGGGGPSQLDPDLVIKCQPDRELATIHSICEIHLSQIQLQAHNSATLKKLATVIEMLTAHKHKYMDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9U5</accession>
    <name>A0A922I9U5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NAT10</name>
        <name evidence="14" type="ORF">DERF_000950</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9U5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="973"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="572"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="641"/>
            <end position="643"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="648"/>
            <end position="654"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9526892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="997" mass="113546" checksum="529CFE8ABEE1EA40" modified="2023-02-22" version="1">MAIKKLDNRLRILIENGIILGHRTMFVIIGPKARDQVVILHQMLSKSQVKARPSVLWCYKKELGFSSHRKKRMRLLQKKMKSGVELDNLEDMFETFIAQTDIRYCYYKETHKILGNTYGMLILQDFEAITPNILARTIETVEGGGIVCVLLNQITSLRQLYTMTMDVHTRYRTEAHQDVVARFNERFILSLSSCKKCVIVDDKLDIVPISSNLSEIVAIPRNDSTELSAEQIQLKELKESLKETQPIGSIVNLCRTLDQAQAVLKFIDVISEKTLSSTVSLTASRGRGKSAALGLSIAAAVAFNYSNIYVTSPSPENLKTLFEFILKGFDAISLKEHLDYDIIQSTNEEFNKAIVRVNIYREHRQCIQYIHPADAVKANFLAQSAELLVIDEAAAIPLPIVKSLIGPYLMFMSSTINGYEGTGRSLSLKLLQQLRQQSRRSDKQPKNNHDDNISGHGRVLHELTLNESIRYKNGDDVEQWLYQLLCLDAATAGSNEVSEDLKIGSGGCPLPADCQLYYINRDILFSYHKTSENFLQRIMALCVSSHYKNSPNDLQMMSDAPAHHLFCLLPPVTSKHLKKSKIPDILCFIQVCLEGEICKDSIMASLSRGQRASGDLIPWTISQQFQDSHFASLSGVRIVRIATNPNYQKMGYGTRALQLLEDYYRGLYNVDLIESINNVDDEANAEDRIKTLDAPLLLDLKERKAEKLDYFGVSFGLTQELLKFWKKSGFIPVYLRQTTNELTGEHSCIMLKQLNNNSITTNNWLHEFWIDFRKRFISLLSYEFSKFSTTFALNILQNVSSSTNDQTTTTTTTTLNKDELFIHISVYDLKRLELYSQNLVDYHLIVDLLPTVTKLYFLNRFDPSFHLSHVQNAILLGIGLQHKNVDTISEEFKLPATQILGLFSRSIKKMTNYFRSLCEKEIEESLRTKNLGQASSLNPLGQSLDDELIEVEKLINDDERKRKKQLAKDLSQFAIKGIIIGNISIFLFCLVWFFNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA64</accession>
    <name>A0A922IA64_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="11">HMG-CoA synthase</shortName>
            <ecNumber evidence="3 11">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HMGCS1</name>
        <name evidence="15" type="ORF">DERF_000448</name>
        <name evidence="14" type="ORF">HUG17_8252</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="function">
        <text evidence="8">This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10189"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="3 11"/>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA64"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 11" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="12">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="13">
        <location>
            <begin position="199"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7640783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9526350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="486" mass="54408" checksum="5012E2E4BC403E06" modified="2023-02-22" version="1">MPVNQIQNGTSSSSSAAAATNGCKWPENVGIIAMDIYFPSSYVDQTDLEEFNGVSKGKYTIGLGQLKMGFTDDREDISSICLTVTESLLKKYQISPVDIGFLMIGTETIIDKSKSIKTVLMDLFKDSGNTDIEGIHATNACYGGTASLFHAIDWIESSSWDGRYALVVAADIAVYASGAARPTGGCGAVAMLIGPNAAIVLDRKVRSTYMANVYDFYKPDLSSEYPYVDGPLSNQCYLQALDQCFNLYFDKANRNRDELLNHNNHSEQQSMIELSHFDGIIFHAPYCKLVQKSVARMHLLNNLRLQAHDPSRFDTKLEKYRNVKLEESYNDREMEKLLLTLSSENFNKRTDPSLMLAREIGNMYTASLYACVISFILSDSVENLTDKRLLLFSYGSGLAASMFSARVTKDKAILSRLMKGLTDVQPRLQQRQRVPPTKFEETLNLREKTHNIAPYEPTGDVSSLMAGTYYITDINQKYHRTYSKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA74</accession>
    <name>A0A922IA74_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NineTeen Complex (NTC) component</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Pre-mrna-splicing factor isy1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ISY1</name>
        <name evidence="7" type="ORF">DERF_002234</name>
        <name evidence="6" type="ORF">HUG17_10199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA74"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7636229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9528277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="280" mass="32581" checksum="DAB03A7CA97F9598" modified="2023-02-22" version="1">MARNAEKAMTTLARWRASQLEEQNNSNQPKRERRPYFPGDCNDLNAAQRWRLNVVRVISRKVAQIQNAGLGEHRIRDLNDQINRLLREKRNWEQRIKELGGTDFKSTERFDASAREIPGNKGYKYFGAAKDLPGVRELLAQETIQVPKKTKAELMRSIDADYYGYRDEDDGVILKEEARVQREELLRLANEEKNSNTTTIKERIELICYADVNDDSRQSVEDGIDFAGPKNFISHVPSIPTQKEINEELIRRKKQELLKMYVSEDILESEKESKKILDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBB0</accession>
    <name>A0A922IBB0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase F1 subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_002329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBB0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000007">
        <property type="entry name" value="ATPase inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9528376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="148" mass="16733" checksum="B52896058F555535" modified="2023-02-22" version="1">MNRMRVNALIFFSIKGQTIFDSSFSSDIFHFCFSLNKSDLIMNRIIGNRTTLTNLLININKASSRNMSGEWGAGSGKGGGSGGSVRDAGGAFGRMEAAREEEFFRRKQQQELEKLRQALDSQRSELQKQIKEHEAEIERLRKIQKDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBF1</accession>
    <name>A0A922IBF1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002845</name>
        <name evidence="2" type="ORF">HUG17_4932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBF1"/>
    <dbReference type="OrthoDB" id="6509232at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324715" evidence="1">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="127" mass="13821" checksum="80877DC41F57511D" modified="2023-02-22" version="1">MNHPNKYNFLLTTVMATAVLLMTIRSCHSAPFITKTDKGVDINVWPFFRMHLARETRGMVLGIEVLSGMVKVNYDRKPGEKPFVNVSVFGLGGSGDGAAKAKIPVDDIESGLGELKAALESETNLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC71</accession>
    <name>A0A922IC71_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002103</name>
        <name evidence="2" type="ORF">HUG17_7012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC71"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276963" evidence="1">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7636806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="100" mass="11091" checksum="F2334E96FF9F6EC5" modified="2023-02-22" version="1">MKGFVVVILALTMALVTMSHAQSEMPSMPECPDSESIFTWISDTAKFAAKYGAAAVEYINCMRKSADISCVTEWIKFLLGFGERPICYPHSHAKCVFYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ID63</accession>
    <name>A0A922ID63_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LGALS8</name>
        <name evidence="5" type="ORF">DERF_003241</name>
        <name evidence="4" type="ORF">HUG17_5245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ID63"/>
    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF147">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="194"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7642200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9529351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="333" mass="37940" checksum="3A7FAA83927173F1" modified="2023-02-22" version="1">MDSILKKSKKLIDSVVTLPSNKNSKSRYLSLNEGLTQNTRIWIEGKVNPAASRFEINLWCASVVNEDLVKNGDIAMHFCVHSSAGYALLNSRTGKIWGQEERTARGRLPRPLLQNQNFRLCIEAEPTQYRIDVNDNEFVTFIHRHSFESVGLLSYDGDFEVENIFIQPPPAMVSAPLAEDSHVVKDLKWPKLPLLLPIKSGLQVGMIFAIDGRVTGNRFDISFYQGSNPYEDHNANVPFHMEIYMDSKAIVRNSNQLKQWCQPEKELTHFPFFGHSAFNMQIRVEGNRYQVIVGGRYVFDFYHRISALTTINHLCIHGGVEIHSLIITIPPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDH3</accession>
    <name>A0A922IDH3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphohexomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphomannose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_001332</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDH3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="12">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="13">
        <location>
            <begin position="172"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9527309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="415" mass="47194" checksum="DB8307A0CE46697B" modified="2023-02-22" version="1">MVIPLRCCVKKYEWGKRGMDSCIARFLRNQMPSYTVDDDTPFAELWMGTHPSGPSVVVGSTPDQNNITLLNFLSNYPEYAGNVRVVTKFGKNLPFLFKVLSVRKALSIQAHPDKALAEKLHHDDPFHYPDANHKPELAIALTEFEALCGFRPHEEIEFFLNNVPEFKNVVGTDAAKTFSETADKKQGLKDMFTSMMNSSENVIRENLTSLQARWYWSNQSESNQQLETIRKVFVKLNKEFPNDIGCFSIFWFNYLVLQPGDAIFIGEDEPHAYFRGDCIECMACSDNVVRAGLTPKFKDVKTLCNMLTYNSRAPKEQHCQPMVVDKFTKSYIVPVPEYVVDAIEIGQEHISATFQYQLDAKESGSVVVVIRGEAKVQDQKIFTGYVGFIPAQTKLIISDVKSPLLIYRAYCRLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDI4</accession>
    <name>A0A922IDI4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDI4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09106">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09107">
        <property type="entry name" value="PLDc_vPLD3_4_5_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050874">
        <property type="entry name" value="Diverse_PLD-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185:SF17">
        <property type="entry name" value="GM01519P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10185">
        <property type="entry name" value="PHOSPHOLIPASE D - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="561" mass="64229" checksum="0FF86839CA6E3627" modified="2023-02-22" version="1">MSSLQSYINIPKDLLYHCFSYLNYSSQKMATQSATPKLDFKLITEYYSSSPWIKIAAITGAAAVVMGAYGAHGLKNTEKRAIYETANKYHFYHSLALLATPFVRRSNLVGSLFLGGIAIFSGTCYCNAITDNNLVVRFTPIGVSGTLFTRRSFIVETLPHELNYNDENKSKPTADAWLELINSANHSIDIASMYWTMFGKDVMQNPVPESKKGEKFIAALIDAARNRSIRLRIAVNDEKSNDNDNNEDLKLLQKYSQIRRVNFVRLIGAGVLHTKFIIVDRKDFYIGSANMDWRSLTHVKELGIIIQNNPELAEDLLKIFDIYWSMGEQNSVIPMPWPSIYDARYNVTNPYRNQINPDDDEYSIFLTSSPRQFCSSTRTNDLDAIIDIINEAEKFIYIAVMDYYPLFLYEKKSHYWPIIDDALRRAVWERNVHVRLLASHWNDTRPYMTLFLKSLQALNGGDNENTLNGSIETKLFTFPMCPFIKNPIPYSEVNHNKYMITDKVVYIGTSNWSADYFVNTAGVGIVMNVTTTNSKHSTSLYNQIQRIFLRDWNSNYAKNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDK6</accession>
    <name>A0A922IDK6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_003385</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDK6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037126799" description="Alkaline phosphatase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9529504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="513" mass="57762" checksum="34A6DFC1022B23F9" modified="2023-02-22" version="1">MMNFSLFFYLCFFLVNWISCSNHKDPVYWRELSRNALYHSKTFLSDDDIKQAKNVIIFLGDGMGMPSISAARLLKRQITNKNDDHLVFEQFDHTALIQTYNIDYAVPDSAGTGTAFCTGVKTNRGTIGVNGNVNYKDTNCELLQENIVETVFEKAAKSGKSVGFVTTASITDATPAATYAHVSSRYDESSSSLNDDKCKDIALQLIEDHTEYRVMLGGGRKNFLPKGKEVGKREDNRDLFEEWQYKLGNQTNHHHYEFVSTKQELSEIDYDKVDYLLGSFCENHMKFDKELKNDTSETEPTIEEMTVAALQILKKNKNGFFLMVEGAKIDKAHHTNQAFYSLHDLLAFEKAIIKAQSMVNLKETLIIVTADHSHSFTHSGSSLMTNDLFGFSDYTDRDGKNFTSLIYSTGPGYKESRNYTEKEIKQIDFAQISAVPLDSATHGGDDVAAYATGPGSNLLRGSQEQTYIAHLMEFASCIGDYEHEPHCSGCKMLICSTVIIMIVFISHLIRFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDR7</accession>
    <name>A0A922IDR7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_002898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDR7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="5">
        <location>
            <begin position="84"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9528988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="192" mass="22365" checksum="2C48643A490BD215" modified="2023-02-22" version="1">MNRKMKRQSTIKTNKKLESTRKNNIIMAKWWNALNSGVLDDQKSCIFCANQCRKQWLPIFCSKHYWKGVKSHYRFAICFVIIRKVENLKPLFNQVGIRIDCFAGQTNPLGGIQEVDVAVCTIEKANNMINRLIEEREMYRIGLVIVDELHMIGDTSRGYILELMLSKLIYMKLNVDLRQLQIIGYVSNDTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE45</accession>
    <name>A0A922IE45_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_001007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. NFIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE45"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000025">
        <property type="entry name" value="nuclear factor interleukin-3-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF27">
        <property type="entry name" value="GH27708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="146"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9526953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="240" mass="28199" checksum="9F1F819A9DB79859" modified="2023-02-22" version="1">MYPSNQTSVITKNVQIQQQQQQQQQQQQQQQQLKHSVQTMVMMTNDDELSNHRFTDCSHYDDDDDYDQQRLSYSPSNSYSSSSPTSSQISDYYHHHHHHSSTSPSLESHSSMTKFESSSSPTNLIACDHYSKRKRQPIPVPSENKDDAYWERRRRNNESAKRSRESRRRKEMQTTIGIMVLEQENVKLRAEVNLLREELNRLRQNELLQYLMMNNNNKTTTTAAAAQSPDLIKINHQNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEI2</accession>
    <name>A0A922IEI2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEI2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="875"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="994" mass="109738" checksum="34FABAA44B2848F4" modified="2023-02-22" version="1">MDSFTMAEGIHFIRLLFPEKSKMSLNKTRLDFYANKHHKIKSRTKPPSAYTGSALSSTTNSTNQCNNDPKSLLLSSVENITGIASKSNINTSCPGTKIQIHNPIHYTPTASSSSSSTFGSSYRPHLSSLGSNNSNNSTYNGVTNKPSRFVRHSGPGRSIRAQSLLSTVKVSKHSLGPSTKSIVAKTSNTSNYEINESTDDSEHHYRVEMISRSTSPTRPTSSKIIDTDAQNNGDSIIVENDDNDNNDPDDGRGSNHDDEQQKVHQSRCSICSVERIFVDRPKKCIFGIQKCHQAIQTTAMNSDEDLNSNSLNDLSSSCSSSTSYSTVKYDNTDGIRSRPTSNSQQNEYSRFSSSSSSSLINKNNKNNRYSHLMCNTIRTTNRFASAPVIARSSLNRNNTTQYKTKFGTQTPSSSSSSSSTLLISGRKNQNFIVEKSSLKVLSKNGQSMSNDNVQDFDKSSSSSSSSTSSISIHRPLSPTQLIAVNNCQSINQESSSAFNNDSHQITSLITELYNDDDDDSSELNSLNSNHSRVDSTKNCPIPTSDYDDDDNNNNSEIIQQQQQISSSSSASLSSAISPIQKQNSGSYDNINLLTIIKLDNNSLERSASAEPLSCSRNLTNNSNDKTRSSSSSSSSSATPSVSSMSTDNDYDVADRIIMNETKSTTTKNDSSENEDDTYEDASENYDDDDDDECNNTFTIRLSSAQSNRTVISCDSFIDDNDDQDGYNLNDKKLNINNVVHVDNDEQKNDEIEIENAITCIQNEVTSLKESSHSLIHSSSNSFNNNNNNNSGSNHSSQDSINSLGNSTMVNGETMMDNNNNNKNDLNVLQQPQRQQELNDFISKCKDIDEMIGPITPTSPNYFQALRKFKFENVREKFEQQQQDNNNSSNGNGKTVSIDASHVRVHCPNKPMHSTVEFLTEEIDSSVVRIRENKALSGHLSKVFDDVEKNYTRKQSTISANHSHNNDNINDSIEQFYSSSINGNHQHQQSSSVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEQ6</accession>
    <name>A0A922IEQ6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Regulator of rDNA transcription protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_003985</name>
        <name evidence="3" type="ORF">DERF_004697</name>
        <name evidence="2" type="ORF">DERF_014871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEQ6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9521020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9530161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="36966" checksum="C11AE5B2FB31494E" modified="2023-02-22" version="1">MSESAVPLVLSRISIVTTWLISRWVNNPTLGEFCFAMIGRADIEGSKSDVAMNAWPPQASYPCGRAFAVRIRTGNQDQASFCPFTLREVSVLTELALGHLRYLLTDVPPQSNSPPGSVLDQDRAEYVPETRKGNRSRSLNARNVVLLRPVSFQSRSRGVAMAFRGQTSARVQSRRFQHNQSQPDASPVSDHSPNGPSFRANPYPEKLEAVNLGDLLRILVRLSTKVNLAFGFSRTDNSAPDSARTAELFSSNIHISRQAVFMDSKLYREKTTLPRTAADVSKFDSVTALVPESTSFLSQFGNIDPIPFRKISHGIIQLKPGRCNGFHRFLRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF44</accession>
    <name>A0A922IF44_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="6">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LCMT1</name>
        <name evidence="9" type="ORF">DERF_003202</name>
        <name evidence="8" type="ORF">HUG17_5206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="6"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF44"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7642161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9529311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="304" mass="36053" checksum="E5A9D2F493F45023" modified="2023-02-22" version="1">MYSNTEWTNNEASRTKLWLSQQGYIDDPFVKNFCQNPMKRAPEINRGYFARVYSITHSVKRFCLKDGANCQIVNIGSGFDTLFWRLIKNSDIQFNRYVDIDTNEVIDYKIRTILKNEELLQFCGKVEKSSPSQFISERYNAIALDATKAMQLVRQLLQECRINKTDPIIFIFECVLLYWPEESTTNLIYTLNKTFTNCNFVIFDLVNTKDKFSDLMQQSLVEQQTPLLGANSFRTIDDWQTKLSKMKCSHVHAWIMNDVYYKLIQQNERERIEKIEFFDEIELMLQLFNHYCLVMASNYSNFDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFG7</accession>
    <name>A0A922IFG7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L3, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MRPL3</name>
        <name evidence="7" type="ORF">DERF_003444</name>
        <name evidence="6" type="ORF">HUG17_5393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFG7"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7642348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9529566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="409" mass="47387" checksum="FB3B3C8AD633BDE1" modified="2023-02-22" version="1">MFRSLIQIYSKNFGRTSINQLSININLNDSKTVNSILTISVRNGRFSAPTTKRRKTYPYHWWPRAEKTSTLKNYLTKENQKFLDDIDHNKISPFQNNKSPLKIEQVEKCQYEEGSIRCGVIAKKIGVQPMWTKNGQRIVTTVLQIIDNHVISYIKNEDFIRARRPFYNQHKYKDMDVLIVGAENASHLNYPSSYLGLFQKANLPPKKKLTRFFITPNAKLTPGTALTVNHFCVGHYVDVWGKTRDYGFQGVIKRWKFKGQPKQHGVTKAHRRPGTIARGRKLMGPLKGTKMAGHMGSERRILKGLKIWRINTKYNVIWVHGPAVPGANNSWVYIYDTTSKAKKYKKDNHPPFPTYYEEESEEKLPENIYDKDLHPFDEPSLLFEETEEERKAALAALKMTKKAKIAKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFM1</accession>
    <name>A0A922IFM1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 170A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_003196</name>
        <name evidence="7" type="ORF">HUG17_5201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFM1"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7642156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9529305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14793" checksum="530F1A1B4041CF5D" modified="2023-02-22" version="1">MGLGHSKDFDTSILGSFWDVIILGNQPIETFLAMWYYIFLWSLVSSVIIHLIASAIAFASLRRHKIARYSPIVILLSSIITPLFSYSITSAVIASVYRTASFVMYPIYAMFWGCGLTMSTTLFSFSRVLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG63</accession>
    <name>A0A922IG63_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_004019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG63"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9530196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="102" mass="11171" checksum="F66DBB8AAEAC244F" modified="2023-02-22" version="1">MHNCCGAIDGKNIRIRCPNQSGSSFFNSKGYFSIVLQAVADAYHRFRIVRVGSCGRSADSGVFSNSQLGINMRTGNTPFPRSVDRLPGSEKESQFFFIGDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG88</accession>
    <name>A0A922IG88_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_003718</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG88"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000026">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000045">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="898"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="927"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="964"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1017"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1058"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="42"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="186"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="14">
        <location>
            <begin position="280"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9529860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1190" mass="134835" checksum="0550F86B2088B3F5" modified="2023-02-22" version="1">MNNNVEKTTNKHYASKTDAFKSKKVNPPPIRPGVRYINAEDEDQMEIYGFTPNPLKTFVTWAAIILTCGILRLIFHWKPHWMLFCTHNKCSLENAKKVLLIDHFMQKFTENVVHIMNDQLSYHQIGNSNPTGWSAIPKANGQFEYVDSIIYFENKKVRYVWDNDSKEFYKVRGLDKDIKCTYFYNQKGLTASEQKQRRKIYGLNEIEVTVQTVMQILFQEVLEPFYIFQVFSLIVWTCDSYYYYASCIVVMSALSLTSSVIQTRRNQKQLRDTVQGTDTVNVCRAKDDVYEKIESTQLVPGDIIEVPSFGCTMQCDAVLVSGNVIVMNQCLRVSESVPVTKTPLPSTSLQMSYNAKEHAKHTLFCGTKVIQTRYYNNVKVRAVVIRIGYQTAKGELVRSIMFPKPVDFKLNRHIHKFVGFLAMMALIGFHLYCCIENSTWSQLAKYSLPAAMTIGVVFAQSRLRESEIFCISPRSINISGCINCVCFDKTGTLTEDDLSFSEIVPINKTLNRFGSSIIDLADLEYGPLLISLASCHSLTLIEGKMIGDPLDQKMFEATGWILEEPDVNDSSKYDLLAPSVVRPKSDYENKEVGIIRQFPFSSSLQRMSVVVRQINGTQFELHAKGSPEMIVSLCDPTSLPSDYTSTLQEYTEKGYRVLGLAYRPLTSLNYHKIQRAAREDLEKNLTFLGLLVMGNMLKPETTEVIETLIMANIRTVMVTGDNMLTALSVARECSMIQPWHKVILLEIDPETVTADVPKLYWKFANAAHISDSIKYKLSSMDERDKTHVAVSGKTFHVLREHYPDILKRVAVRGTVFARMSPEQKQYLIELLQEIGYYVGMCGDGANDCGALKAAHAGVSLSETEASVASPFTSKRPNISCIPTLIREGRASIVTAFGILKYMACYSLTQFISVIILYTFYSNLTDKEFLYIDLFLITLFVMLFGRNRAFDRLDRNPPPSSLIGLTPLASIVLQIILVTIMQVLSIMIVKEQPWYQPHVANADDDDLASHDNYALFRFIQLFLLSLIVMTILTAILVVYPPVFIANFFELFMKHVTLEFRITMLLLALAHFILAIFLEVIVVDYFLFKKSHCFSFLNKSSESSSSSSCLYKTLDKETNKNTLWLPQQLSLSSPLSMDILESNNSNDGGSGGGGMMIISSNTEKSTQHNTNLLPINGDHHHHHHHHDAYLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KT47</accession>
    <name>A0A922KT47_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="4">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TSTA3</name>
        <name evidence="10" type="ORF">DERF_014486</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KT47"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43238:SF1">
        <property type="entry name" value="GDP-L-FUCOSE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="9">
        <location>
            <begin position="45"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9493753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="383" mass="43637" checksum="1235E525CD7D510E" modified="2023-02-22" version="1" fragment="single">TSKGQTLFIFSIKFHHQNSSLSISKVFEIQQYLMASGQMANEQIVLVTGGSGLVGQAIRTIVEQESKAEYSSKYQFIFVSTKDGDLSNVDEARQIFEKYRPNYVIHLAAMVGGLFRNLKYNLEFLRTNLAINDNVLLLAKEFRVRKCVSCLSTCIFPDKTTYPIDETMVHLGPPHHSNFGYSYAKRMIDILNHAYSDHFKNNSSDYGGSDNLPIFTSIIPTNVYGPYDNFNLEDSHVIPGLIYKAYNAVQDAKLKNSNTAKLLVFGSGRPRRQFIYSLDLAKLILWTLENYNEIEPIILSVDENDEISIGDAAKMVADTFNRSYPDIRMEIQFDTNYSDGQFKKTASNSKLRRYLPGFCFTSMSDGIRDTVRWFITNYDVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KWE8</accession>
    <name>A0A922KWE8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NEDD8 protease nep2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">Nep2_5</name>
        <name evidence="11" type="ORF">DERF_011891</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="729"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="1194"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="1467"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="1964"/>
            <end position="2076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9501019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2080" mass="245714" checksum="4F36E709E86A6705" modified="2023-02-22" version="1">MTDELLKLTLEVDTHSPGKYRLNGVVSNSEYFANDFYCPPQSSMNPRNNVYRKKMFQRKLFLLAIFSYMAIGQCAFKNNSLDCHRNILTEMDKHLRSMELVHGDQQFPESLEELKAHCGRNKKVIDLMSKMADKCMTGFTKNIMQVTIYSLRRSRKSICKNKPNKEMLALINAGKCVNGGRKRFSKCVKHAQIHIETVKDMPTKKRIPLILKFCMLDKAKDVNECSEQNVETLQRRFTHISANSMNMACGDYTEDSNRCDTLKMYNNNLTLHTNKLYVEILGTNIEQNLLNRMSINLLESRLKVLCFHEENLYKLQSTFEQTKHPSSYKLQLLLDEISNCLVNMKSTTEQVLKNKRNQENENKWKNSKQIDSSYDGYRSSSYEDPIKLSESKSENVNDYKYVYQLSASSSNESLIGYEKLVSKINMQDENDDNSDNESANSSHIPYDYLHDDGDENHESSKVLVDNPTSSHTSKVSQVNCVNFDDLFNEGNLFYIYDEWRNWFDFNPDLDERFGLDFYNDKAFKNLEKPQKDDDFHISLYKIFSDKNPWNKDEKLTQIENLQINTKQDLLMLVECVYYKWIFTRNVHDHLFDVCNELFDELAVIEENSSLVHITFGQLLSSKCRSLFFISDNLDAQSLTFFQFDQEKNLSKNPSKKESSPFKPDVSKITFGRLKETLNAYDLVFRLVSLLFIFNVFLHYYELEQRNCHNDACKSFTNKIIDSIDYTVNPCDDFYQFVCGNWIRNIELPPEVDSIEPMIMVKINLKRQLRNVLVNAWDIDNNHINRKIIKSNSWAVKWAIKLYHLCMTTTVPKNAKFLQKKFYQKWSKLGLPRVLNWPIVLEKDKTIINENFAIDWIEIYANFYHEFGFGPIIEFDVGPIGWDKDSIIFDFSRFLLESLRYEDENIDYFYNRPYELMKMIKQFDPSINISDKVLRVAMMEVVWMEKSIARQINNEFGENVKIQLDRLYLRTKPANMTNFLNKMYKFSQQLEHVNVNNMSNYQWNDKDYVGIQQKLPAYHSIFDNIAKNPKHILYNFLWIKALEYTMEESLPKSADQCFYMMYDDKFELQFALARIWIDYWLKSGSKLKTVEMVNYLKQATIEIIKSNEWLDEQTKNLVIDKIRAIVDEVAFPEWILVDEELDAFYGMFDLLHHQIPDNYFDAYVLLKQIIIANIFHRTKGRTNWKFNLISPISVNAAYQSLKNTIHIAAAILNAPVFDPELPFYINYGMLGFIIGHEITHSLDETGFSYNKVGLKTNWWTNESMEKFENLTECFVRLYDDHNEEWKELFDGYRTLGENIADNGGIRIAYHAYRLRLKQLKHIGRTVNLLPWLSTNFTIDQIFFISFARLFCKQETNEHAYELAEYDSHSPHKYRVNVVLGNFEQFSQSFHCSKNSTMNFNQRCIICIHESKLEKTLSISSIVLFMALLINNICIYFYYDDATDMFCMSETCDNYSKSLLQSLDYSVDPCDNFYRFACGTMIENMNATKDDYYGTTFLTKMDDIVRDRVQYLLMNSWDVSKNKINRKIIKSKSLAIEWIIRVFQQCLHMPKPKNFYKSFHELWNKLPISSKLLWPLESNSSDHMIDMNWLDFYAYYSDHFGYEPLFKIRFFLQTKLQIKIDFHSSLHQTVQQHYTKQMTNYLYELSRNYNISRMSKENYKKIVDNVIDFEKKITNIVSNTPPIIVNYSLPSFERFTEIKLSNYFHILFTIINKPKINQSSWKSENSTNFITNNDFLVIHKLEAFVYVMDVIRKTPKHVVFNYFWLKALSYWWTENQPNKPENCFQIFYSNEFPLTFAITRLYIDRWFKPGSKLKAIHMVNQLKQSAIQSMEMNTFLDDETREQAVQKLRNIIDNIAFPEWLIIDDHLDEFYGVQGSSIDSLIANHYCQSYVQMLRLDKYRMLKFLNNDEFDFPEIHTLSLQVNAFYSPVKNKIEIKATLLMLPLFDVELPFYINYVDNHMVFQINTSSLNEDIADNGGVRFAYKAYRTELKRIENLERRPQLLPRLVAKKITIEQLFFLSLAQIECAVLTPAQLLNRIKFDPHSPPESRINLSFRNFDKFAKSFNCPIGSPMNPEERCILWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KWM9</accession>
    <name>A0A922KWM9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KWM9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8222" checksum="FD79EE5ED2698839" modified="2023-02-22" version="1">MLVCLLIILSNCDHSAHVIKAQSINLVTFMMMAIRKKMISWNNIEKLAILCVTINFYISIVAMIQNINIELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KXZ1</accession>
    <name>A0A922KXZ1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KXZ1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="390" mass="42640" checksum="7C706E11BB19AAD6" modified="2023-02-22" version="1">MKNDITFIEKISGSIVVLYRICLTGCRMRPVFVRNSGGISSLNDSSITINLICKNKKQTFFDVLKSSSSSKSSDSESKILLAAVFLDAVVLFPPAVVAFFDLVFFEAADITKSELFESSSLSSSSSSSSSSLCGLSSSSSSSLSANVRCGGGVVVVVVVVVIVGGSFSSLRLLVNAFFLSTNSGDTPIRCANGMYSFSLSESIAMTLLFVEAISTLFTGLSEFVFLNNSESILGTIRSPSGDAVHVQIVQHDLIHQEIVLNLLPKDLLMLKVEPDFQVSTFQLLKYLHNRLYVWHNIQDEPDRILAEFLLIFFRQCNDEFNSRILQTRIGSSVISNDLPLSNIAASPFITNRCVSICSIVPLNPLNHGFIDRISRPCIKRRILSTISRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY02</accession>
    <name>A0A922KY02_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY02"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036826353" evidence="2">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7369" checksum="D56DA07886FC991B" modified="2023-02-22" version="1">MMRCNIASSLMLTIVELLLFLMQKQRRAPNTSQSYNIHSAIHPIQKKGPIKPKRNEMKRSFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY89</accession>
    <name>A0A922KY89_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein fem-1 B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FEM1B</name>
        <name evidence="9" type="ORF">DERF_013177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY89"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="5" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="7" id="KW-1053">Target membrane</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9497173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="851" mass="100577" checksum="C88DF2E58716E896" modified="2023-02-22" version="1">MDDPKRRDDINKYSAHQEFLFHNFFKKCIYHYKIRGENKDPTNFVSMLTDDDPEFIAEILNSYCLIQLSANSKIMENLLQGDSKYSFTPIHFFVLFKAGDKFLQFFLKRFSHINIDQKANIFCPLSDDLLSDVTPLWIATLLGMTKQMSLLLEYGADPNTINSTGSTPIRLCCEISHENTEDKLIEQLELLLKHKADVNKPNKFRNTPLMLASYNGIEKIVRILLDNGADPNLAAYCGGTPLHFAVECGHITVIEMLLQHGATLQPDISGFTPLFLAAFMNRTDIIDILQSWMEKSNQLTIEDQMNETNDSKISRFLRNAYLLRYFPLDYNGSFDNISTSKCVDPKALPIRPKNIHQARYTYDFAQETQTLDEFETIRNDDDDDVRLHYECLFAIERFFTNDCFKLANCLEKMGDHFVNEFDENDTALKLWIRAIQIKIKLKVFVAGVYERCFMHLIYKTYEWRQFQYWQTLFELAIQYLESFPLPDGLQAMSFQLDIHELCQIEYFTRNDVKIKNSIPFDIEKSHDKMDELWDINRVINAIYSFICYFSKHYNRLGDVKQNVIEKIIRKFLKLNFTNVYYHRHMIQIIFYPDHWRFHFCFDFGFDFSFGFPHINQIKLLLKCGANTNVYDDLYNTPLHYLSYNGRERGMSIRKLVPYFNELVDHIYYGKYVHNSLHHFDYAGLQSVHLDAVNIYNQTAFHIYPNLLFCYKQPNLNLFPLKCLAARVSHRIYLRCKNCKNVFTNLYEKIESILNRMDGYYDPQEKLHEKFRNLPLHPSINKSLPNTMEIYPHKHQIKPYRAKEVWKLIDKYSERLKISAKLLEFIELHGPCKFIHQIDCDEQQETSDISFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYH9</accession>
    <name>A0A922KYH9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_013378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYH9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="4">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Transposase Tc1-like" evidence="3">
        <location>
            <begin position="68"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9497383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="219" mass="25210" checksum="44CC02A423E2FB7A" modified="2023-02-22" version="1">MDKQLEKTVLRRMVIQYHKDGLSIRKIAEKVERSKSNVQHIIKTYRQNGQTNAIKPPGRPGPTEQTLRRLGRQIEKTPAITGKELANHLDVSRNTVQKYTKMTEYNVRIARKKPLLSKKNINKRRLWANKMAEMPLDYWKKVIFSDESRFSQFSDAYRTFVYHKKNQAYQAKRLQATAILIEQISNDDDGQNNSDDDGQNNFGDDGQNNGDGGQNVGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZ61</accession>
    <name>A0A922KZ61_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_010579</name>
        <name evidence="2" type="ORF">HUG17_9764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZ61"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7643073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9505808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="294" mass="34400" checksum="4462C68F6A93D6FC" modified="2023-02-22" version="1">MVDTTCVNIAEAIITPDDNKTLCSSIMEPPFDFTCDSVILDGYAKNLLNSSTITVHETFEDVVGVDLEIVNKKNPCKCDELKKEKLLLAKKLEECHQECQEYRNLIEEKDKINEDLRHKIETIENKIEITKQRDPERVAIQDKIYVQKFGKKFYDYFLNDFDLYRYKFPNFNDSIMKLLNDKDQQVNTGDMNGQLNNMIDDIIEDLKSKLLLADIGADKISDKRLLLNSISGTIFRFIFKKLMSRFPLLEQKYNSLNLNLEKNLLQCLMDKVCNKKNGTRKLYRKKYKNLPDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZB5</accession>
    <name>A0A922KZB5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">USP47</name>
        <name evidence="1" type="ORF">DERF_011330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZB5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="196" mass="22579" checksum="C73BFA6EF0AF81E6" modified="2023-02-22" version="1">MNTNSLRGLAALMVIDGIDHTTNSNQPVDILKFRLADSCSIFQAELFAIYQASEWLKRTNQSAKIFIDSYSAILACCSIQFLSGHGKFRYYLYNIGYSTVSSCWCGIDTKNSIHLICYCPRYIEHSYSKWLEKNGKTNSLRGLAALMRRWFSGRMLACQQFKHHFRRIRKFAGGPGSIPGRRNWSINLFDQYPNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZS4</accession>
    <name>A0A922KZS4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZS4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6802" checksum="644061EF40BA741B" modified="2023-02-22" version="1">MGHRKNHPNEKKTDENGSKIFFFFGSEKKDLSILNDLTISNVCFICFFSIITILSSLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0Z5</accession>
    <name>A0A922L0Z5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0Z5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9505987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="87" mass="10327" checksum="DE18A2CE93CF3CC9" modified="2023-02-22" version="1">MTIMNDRNRTEPRIILLTNHDYFIMKSLLILIRIMLFILITTSIIVFIRQYYIHIEVQQRIHHALNDRGTLDWPMPVAFLSSSPESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L255</accession>
    <name>A0A922L255_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L255"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9502055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="105" mass="11674" checksum="3E46C7FBC07C4896" modified="2023-02-22" version="1">MRPPNISMSSTNCSSNNNNNNNKKDANIKNVHSMPILSSSTTLTTTTSISSPSNTTTTTTSIISAITQQQRNHHHMKIFLIVLKKLVQLGNLTSLPLHHHHHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2A2</accession>
    <name>A0A922L2A2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2A2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7303" checksum="A43254D058A010BA" modified="2023-02-22" version="1">MKPASAPAPTYFDDLIPGLSEPLETGSQEMKQKKPYITIESIETTNKKPKSILSIHWLQSPTNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3M1</accession>
    <name>A0A922L3M1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3M1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9481" checksum="A2A1F399AC1B52F0" modified="2023-02-22" version="1">MTRIQTSSGPMMVSRMIFNDTTTFELQNDYCWLCCERTIDCVLLDCGHLISCLSCAQQKIRRFGPVCRRIVWKVARIYLAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5E5</accession>
    <name>A0A922L5E5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component Sec8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EXOC4_1</name>
        <name evidence="9" type="ORF">DERF_004329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039682">
        <property type="entry name" value="Sec8/EXOC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007191">
        <property type="entry name" value="Sec8_exocyst_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048630">
        <property type="entry name" value="Sec8_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14146:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20652">
        <property type="entry name" value="Sec8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04048">
        <property type="entry name" value="Sec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec8 N-terminal" evidence="7">
        <location>
            <begin position="45"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec8 middle helical bundle" evidence="8">
        <location>
            <begin position="308"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="624"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="709"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="853"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1222"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="639"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="853"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1222"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9520629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1424" mass="158849" checksum="8DFE2555F8855FD2" modified="2023-02-22" version="1">MAEPAPIRPQRIIRANREITGGLLMSVIRSLTTSRDSADRDRERLELEKGFQQCDAKLNELISQHGNDLYKVMTIFSTILTNLSRAKERLIDTRDKLLNCQKLLHCKREELKKLWLEIIENRAVFNLLERIERVSALPRQVESYADKKHYLHAGKCCVDGLRQLGCSESSPCLSSVGELDPSSTTTNGFQSPSSAMGNNQFDFSLGKIEALTEVRQELLTKKEMLFDKCIEELHRHLYSITTENVRKQFQNEQQQRQIRETSNSNQNHKPSVIYDNLRLYENQMIKTDQQQQSQSTAIQDENDFDAYPEEDSRQFISMLTKCIGLLNKIPDAVKIIKERFDEEFVNVVIRTAQDILISNQNDSIVDSLAAANNTDSMSLMDLDADGIPDVSSMAVVNSTPTPNTGQDLVVLTCTRLLGYRYNGFSHLQSSANDRSYNQLQWPRTSLQLRQLFDMLIQQFYHIMELHDTVILINLKRIDSALHLAAMADNMTIQDPNDVDSNSMAVNTAFYSSIDIWSKIQLLIQQLLDYYLDISQISGQASSTGPIGGAMNYNLVSSLLPSAAVNMLFGLNSAGTTTSVTSSGPVGSGCPDNLSCFFIKRRPMVVAGAMNAVMMMSKNTSNFSNTAAASGSGGQTTGTMDQSDSGTGQSTNVISTVSSGTMSNQSGTLQPVSSGHNLLHSFSQSHWRSNQSNLFKFDHSTQAISWNSFLQQQQRQSETTNADQQGENISTNTDQTDSDNKSANQQQQTSAVNNNINHRLFDSLRSICHQSPDNLVLLHDTLLEHVHKCPLTTASNNNTDSGNSKQQQINILHSYLMSSSEKFTRHINTQLDAMLEQAQKSLESGVTILLQQPVSQTDQSSNAQRSKQSPQNKDKISGSSDSSDQQSPMTPSGPTITIGPGHNVTLLLLESAVLVDVAVHDLSMLMGAMTEYRQHYLGYICNVLTAYKDSCTRLYDTVTTEMIHQPSMTSTLTTNQSLMGGVSNLDLSESSHTSTMLTNSDQRRSILSAYCAHNEDINRLLKSQPNWIQLEMVNQRIRTTASGRTTPSSLIKSHQRYGGVGNAPARRQMMMINRQMSTSMSFDVESPEDVRQRNASEIDILIKMLSQEITQSELLWNQGQLTLLANMQQSFEWLAVRCDHLVQMIQSQSSGSSSSNRRNRMGLSNDSSDVIIATLNQLSVDFEELGQLCLMVLHLEIRVHCCYHLQALDAQFFTTPVPSTMMSTSDHSYSGNRSSNATNSTSTDLSDDGRIMPLLEDLQRMHSEISAAQLSTSKMGYLFEGLGHLMATKFINSAMAVKRVKPNGIKRACRAIYDIQRRLSTLTKSRELALDYARQYFEMLLLTPEEIFSTIIERGRQFKPQEYISAITLLHQSGLSQTGSETGVNTIMANTTTSAASNSLDQHQSNQQLQRLIKRLNHILAEVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5Y1</accession>
    <name>A0A922L5Y1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein disulfide-isomerase tmx3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMX3</name>
        <name evidence="7" type="ORF">DERF_009633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5Y1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9511163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="464" mass="54013" checksum="82C47230C6FF34E9" modified="2023-02-22" version="1">MNHSFSCFIIIIQMMMNTIFRKWKNMFGFCFIIFGPFQQSSLLWPNIQSVQASRVIEMNDRLVDVYPNDKRSFLIKFYAPWCHHCQDLEPVWAQVAQQLHNLDANIVVGRVDCTKYLTAASHFTIRGFPTILYINSQKQIEFKGERIRDDIIDFALRVHGPPIRYLSSCDQLNDLVQDGRRVIFINFGPEADGNFTRLAATFQPYDWFFRSLMLCQDFQPGIYALKSKNVYAKFDYQIHGDLIAWIRRHRFPHFTRFTSTNLHMALSSHKLLAISIVEEYRSSGKLIGQKNVAFKNIMESIANEYSNKEDHFLFGYSSDLITMNSLAIRTVQPIPNLLILNSTTLKYYLLSDNIDEIGDTYQAIRANIEKFLDKIIHEPDTLIYYGGDSYVHRIIRLFFDTLTTILTMYQGNPILTLLLLGLPSSFLAIIVYMTCCSDFLDARDDDLVDPDHDEQQDDEHEKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5Z5</accession>
    <name>A0A922L5Z5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Progestin and adipoQ receptor member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PAQR4</name>
        <name evidence="8" type="ORF">DERF_004841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5Z5"/>
    <dbReference type="OrthoDB" id="535992at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF138">
        <property type="entry name" value="PROGESTIN AND ADIPOQ RECEPTOR FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9521169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="329" mass="38986" checksum="E562AFBB62159F4B" modified="2023-02-22" version="1">MLCLQLIRPYKWWSDLFFSNHHDRYNRQRQKSDKQTIKRGHYRYGLNQMPEYLRFNQWILTGYRSPNLSTIECVQSVCLIHNETVNIMTHVIPIVYIVFNYHTMFGPHLFRSYLTYFHLISCLSSWIGSLCYHIFMNHHCGSKIYRHLLKVDMLGIWITQTFGALTTIQASFIMFDESIRYQSVIIYLMISIFALYKGLTASKAWQRPASFALLVTIRVICFIVRIQTHQYNVKHPHHYHNHPSHFVNDNNTNNQISSIITIISKNQHVIGQEIWPIIGAIIAVTRIPERFFPGKFDYFLNSHNIMHCLVVLGGIHMHWSFIDDIEFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L632</accession>
    <name>A0A922L632_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">CILK1</name>
        <name evidence="25" type="ORF">DERF_007528</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Derf</strain>
            <tissue evidence="25">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Derf</strain>
            <tissue evidence="25">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L632"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000104">
        <property type="entry name" value="serine/threonine-protein kinase MAK isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000071">
        <property type="entry name" value="serine/threonine-protein kinase MAK isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 21 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 22" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="4"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAH9516809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="468" mass="53771" checksum="7B30D1E242706A51" modified="2023-02-22" version="1">MNRYVTLSQLGDGTYGSVFLGQKIDTGERVAIKKMKRKYFSWEECMNLREVKSLQKLSHPNLIKLKEVIREDNTLYFVFEYMKENLYQLIKDREKPFAEKINCNILYQILQGLSFMHKHGFFHRDIKPENLLCMGPELIKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYNSPIDIWAVGCIMAELYTLQPLFPGRSEIDQIFRVTSVLGTPDKNDWSEAYLLANTMNFRFPQFTSIPIETIVGNISNEGLQFLKSTLQWNPQKRPTAIQALKFSYFQNATNYHHQSDKSNSVKTAPTISEYNKKIMTNTASAYNKASTNNMLIKTVPSYIGSPNVDNHSIQQLQMQIGNNHLNQSSLIGQRKSPDNNSLNNSNNNNNNNHKFSMKDQYLSSSRYIAGQNTKKNSYSNSKNSSDQQSTIFGNFRKNSIASNKSAVSNGRKLYASSHYGKTDWSAKYVVVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L669</accession>
    <name>A0A922L669_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L669"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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    </evidence>
    <sequence length="68" mass="7842" checksum="990FD89FE0DA6F5E" modified="2023-02-22" version="1">MIPKPGRPTYDKSNQSVFSRFLAKALEAVRANRIIKATWKRTVRISLPIRFHAMSLNRTCVAEIENQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6D5</accession>
    <name>A0A922L6D5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tbc1 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_005631</name>
        <name evidence="4" type="ORF">HUG17_3405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6D5"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF333">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="348"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="871"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="913"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7639372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9522026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1122" mass="129710" checksum="A965B11B68F52551" modified="2023-02-22" version="1">MSIHNSLKAVKFFRQDSTNRITDYHRQQYTTDHIVDYHVPQLLKIIIEKRHDNNNNNNHNKNQSLTNLSKLKLHLDPQVLNYQVLQTLIVKGFQIECDFFLYYLLDEQFHHIHFGQRRRNSSCSSSLSSSPTSSSSSSSTTSLSPKYLAIKNDDDLIQALDYSLQSRSPLYLVIDLVDFRQLLRMSFKQHHNNHSKKKNDKQKEDSSNNNNNDDGNQSTMDNVSSRLLKYKVLSEWDIVTSSDIILAQTMTKTNSFILNQIEKLKQRAIVQHARLQAELVSTTNVKRKAMLTATNSWLLAEAIYQYLMSNDDTNRPVHGPIHDIWPFLDSEGRVRCQRDFRIAIYRRGMDPNLRRIGWKHLLNVYPDDYTGQERIDFIRIRSETYCQMRDLWQRNRMTDPEVRNVCNMVRKDVRRTDRHHNFYYGPDGGEDDCDDCQTDSDVPHFDNDSNDSENHKSSSTKSKLKTNPNVVSLFNILVTYALNHCYRYCQGMSDLASPLLYVMKDESHAYIAFCALMQRLGENFSTDGGAISRKFRNLKHLLQHYDREFYRYLQRENAEELLFCYRWILLDLKREFPFDDVLEVLEVLWASIPPQSSSGPKSSNSKTSNLMNLFDSDFLYVPNRNSSDNRERQQETDILEKITESQSVEQKKLSTKPLQRPKLRTIKFMPNMLSTDSQTTAQAMDSPSSLTDMDFQIQSSTSGRTSAPLPWDSPNLISKSQHQSDKFEQIQSSSQQQFFRYDIDSFSGDSNYDGDGEDDEDLMANKSMILMMEQDAEDSDSKKPPTDDVSSTCSTFDSGIQRSNTITSYQDLTQSLRKESTNIRHAYPISSSHCNGDCSDDNDEEISTPVNNRIEILSNLSVDHGYLTDGHPQNRCYHSQQSPSRLRSQSTPICQPRLIQFPPKAKQLLGYDPSYDDDYSDGSKTIVSSTSSPLQQLQQQPPEVQVIEAINEQFNNLSAKSVSEEMLNSTIRQMETLKVDSMTTSDHSSCSSSSIELLPTPSEVLLMEQQDQLQRQKQPEEEINEEDFPLISPEQLGSNDAFMLFICLTLLLQNRDHIIRNHLDRNDIQMYFDGLVRKHNVRSVLQDARHLFHTYLAEWRRHHNHHQKQSSSVAAAERNERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6Q7</accession>
    <name>A0A922L6Q7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6Q7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="79" mass="9676" checksum="623380709B974E69" modified="2023-02-22" version="1">MTCDMEFEIFFYLHEQQQQNLTHLFSSKKPIFFPEKTSYFEFQIKKHRPPVFVMDQKSKKQNKKEESLSTILPHYETKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8Y9</accession>
    <name>A0A922L8Y9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="5">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DPP3</name>
        <name evidence="16" type="ORF">DERF_000753</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8Y9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000008">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9526688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="814" mass="93414" checksum="4D1174EC8002D065" modified="2023-02-22" version="1" fragment="single">FSKSSLLIHKVTETFVNRYKIVGKFSGKQTLGLFEPNKNRPFPLQFLSFTSVNNNHKFHYKRPENLFCQIVIQRLLHSSSLTMSSTSKSSEYIYTNDTPVVLLEATSAFEALTASEKKYAHYLSKASWFGSLAVLFQTSPESPLIFALFQRIFATEPIDQLKSVAMDKCEFNEEEWRSFLVYVAAFYSNMGNYRSFGDSKFVPNLSKNKFERLIKSSQAYQKDSKFIDNIWNNLGDAIFSLNHNELTLGFEPNGTTTYWSKNMTENDEKIVKKFLTMNDIEAYNTRAFKDPKTGEYVIRFASIRSTSDPEERDYIDKIKSLEMDGHSFRLERGDYSTILSLMNKNLQKACDSAQNQTERMMIEEYIRHFRSGCLDSHKQGSRYWIKDKKPIVETYIGFIETYRDPAGQRAEFEGFVAMVNKEMSKKFTSLVDNASKFLPLLPWPKEFEMDKFLQPDFTSLDILTFAGSGVPAGINIPNYSEIKQNEGFKNVSLGNVITASLKASKPNFLSENDAELLEKYRIPSFEVIVGLHELLGHGSGKLLQADKDGKLNFDPNKAINPLTGKPVDKWYQAGESYDGKFGSFSSAYEECRAECVGLYLSLNVDVLSIFGFVDQQEARKVVYAAWLEMVQKGIESLKMYNPTVKKWLQAHSQARYVITRVLLESAKDIVSIDQIEQSPIDGKPDLLIKFTNDHQLIETKGRKAIGDFLLKLQIYRSTGDNESAQKMFDYYSAVNNQLEYPYLRFRDIAIDRKKPRRLLVASSTQIDSDNVALKSFESSHEGMINSFQEHFANDQVDIEKILIDLWEKDRIYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8Z4</accession>
    <name>A0A922L8Z4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ELOF1</name>
        <name evidence="8" type="ORF">DERF_000767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8Z4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000002">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9526703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="9730" checksum="DCA6E8C8245DB225" modified="2023-02-22" version="1">MAKKKSKRKPMAAKKPIQPLDTLFNCPFCNHEKSCEVKLDRQRNVGRISCRICFEDFQSSINYLSEPIDVYTEWIDECESVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9B6</accession>
    <name>A0A922L9B6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9B6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="182" mass="21762" checksum="D08AB4D2523B58E6" modified="2023-02-22" version="1">MLIFIIMDLNGYKFSTKFAYVLMILVTFILLFSISLILRAIKIIIDDYRTRRQMIFHWNDLNHPSSMSNQIDDEQQQQEENDENQQMNRRISSSKCKRELLGSTEYHETLNIFPLIIFFSLHKWTRCCSTNNNNDHGDHYTIEFMRNKFSKNINDCHQCRLSIAWTFCHTKGSIIKYCSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA17</accession>
    <name>A0A922LA17_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Domain present in PSD-95, Dlg, and ZO-1/2, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">DFNB31</name>
        <name evidence="2" type="ORF">DERF_001835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA17"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="380" mass="43266" checksum="576B6BBA2672DE6C" modified="2023-02-22" version="1">MIRTIQSILSMNPYIHSSLIPESNIGQHLQDLSDVSIQDNEHRILPISKQIRRPSTSCHRQLPSLPHHYHHHQRSTPTPSPPTLMVTNSGCMVDNLCGVTSSMAMMTERPTIAVDSQDMDPYLNDNDNYYQCYEQKLGLSYFRQRASFNSDQCLMMIPFDQRNVSPDGSDELIVVPRRHSSAMTTVSTSPFRISNRIHCTRDLSPRSKTNNNNNNKHSLSLNDVGIHRRPSMPSTFHILPHRIFQIKYFKYGFYGYFSISECLPFGGHRVRISIHYLILDVIDYFGFFSMPNNRSTMETWFDTIQPIRIPRPKLMSSRTVIAMDLFDGDDHRHMAPSITSGTLNNNIGHNSNGNNNSADMIGSNINNGSIDNGSYPMEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAE7</accession>
    <name>A0A922LAE7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAE7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="170" mass="19761" checksum="E0517A34EE5DA51F" modified="2023-02-22" version="1">MNVFTMDAITTTTTNLNNVDNEQRKFNENNHHRNIFVVFNVFVIIFFLLIILLIISYILLFHKIANDSDQLNNYIDFYLKNWPNIIIQLLTLMALSSACLLATFAIYLLRDQFKCQSPLNFNSCYEEQTTTIILDDQNNSGNTITKRSDDKQINEMDTVGVTIDKQIIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAW1</accession>
    <name>A0A922LAW1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAW1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="8590" checksum="DA74BE2D2025C6D8" modified="2023-02-22" version="1">MNNCDIVVLEKIDRKLACWVADLIPIFVSAHIFAYQSIDCQSIFYRFLFFNIMFSNIDLFSSKWDGDLEEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB22</accession>
    <name>A0A922LB22_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB22"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7140" checksum="FA851BC522F265AD" modified="2023-02-22" version="1">METFNKPVRRELCLALNSCIFDNIVTRMVSTLFANTYEAAIVAWPQSFTSASGENQRIDHSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBB1</accession>
    <name>A0A922LBB1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">E3 ubiquitin-protein ligase MARCHF6</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Membrane-associated RING finger protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Membrane-associated RING-CH protein VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">MARCH6</name>
        <name evidence="23" type="ORF">DERF_003219</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Derf</strain>
            <tissue evidence="23">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Derf</strain>
            <tissue evidence="23">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with DIO2. Interacts with SQLE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBB1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000096">
        <property type="entry name" value="E3 ubiquitin-protein ligase MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="669"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="715"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="760"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="843"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="22">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="198"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH9529329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="942" mass="108826" checksum="71CBCD65F2598E46" modified="2023-02-22" version="1">MMEDNPNADICRVCRCEGTPEKPLYHPCICTGSIKFIHQECLVQWLRYSDKEFCELCNHRFSFIPIYSPDMPKRLPIKDIMSVLLRCLFTAARYWFQYTLVAAAWLGLIPLTAYRIYMFLFNYSWSDVMNFTVEFYKPETLFSDGFYGCCVVMCTLCTFIFVLWLREQIIRVGAPDWLERPFERNALFRLLMRDQNVEPNANNDEDDDEDEGDDDEDNDDEEEDNDEDEDERILDGEVAEINNNTDNNLMVENDAINENENGQENLPAVVQNAGPAINPGGVPEARNGLQLGRARLPAAQNNNNNNPVVAQDWNPVIEWDRGAEDITWERVFGLDGTFAFLENVFWVITLNTLFILGFAFFPYHIGNVLFKRMNVEIIVSPHFDRFIIIFMGYIMIGAILFLMHIVTSLTQFNRIQRFFGFCYIIVKVALLVTLEIGLFPTLIGWWLDICSLPLFDSTLLHRIENFFASPGTSLFIHWLVGLFCIFYFVSFIIMVKEIVRPGLLWFVRNLNDPNFNPINEMINLSIFSHIKRCVYSLIVFGTTILIMIYLPVGLIQNLMPKFLPYNNISSNDSPFTELLIELFLFQLVLPALIDHNDHNNSRKFIKLMIRGWCQVMAYLLDLKSYLLGDNNNNNNNNGNNNDNNNDQANEENIDDASSHNQMYRKPKLFYIRVTFLLVAFWATLLFFGAFTLTVPVLLGRALINFYFGDIRVNEFNTAACGIYAIVIFLQMISVVVRGISRGWTQIITKVTEWIPILCKLAVAAILLLGVIPLLIGLLFEVVLLLPLRVPLGQTPVFYLYQDWAFGVLLTNVICAITMMTDLQFKETLEQVYNNGLANINLRVILFDLAFPNISIIGMILALPYVFVNTLFPLFGATIELQNLVNRRIHSILFVIALLFFLVKYQINKFTRFYEHIRNDKYLVGRRLVNYEPINRSMVQVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LC78</accession>
    <name>A0A922LC78_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycerophosphocholine phosphodiesterase gpcpd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GPCPD1_1</name>
        <name evidence="10" type="ORF">DERF_000028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:60648"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:143891"/>
            <dbReference type="ChEBI" id="CHEBI:143892"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LC78"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047389">
        <property type="term" value="F:glycerophosphocholine phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000032">
        <property type="entry name" value="Glycerophosphoryl diester phosphodiesterase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="9">
        <location>
            <begin position="233"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9525895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="561" mass="63648" checksum="B30FE673549E1B95" modified="2023-02-22" version="1">MSTTINSTKSPIPFAQTSPTSDESFASIHHDALSSSCSSISSNTSTISNDSSTSLSEREMALHIMLYNSIEIISKRFSQTKIYCKFSGFAMDSIDETFDTAQDDDFNHHDGIDQYPFDVAAMNDLEYKFQNQNLFGRSMQTNEFIIVRCKIPLSGNIGIRVDLFQKMETNNNNDSNDIGHDVSFNKIAFGYIYPVNASESSGIFTVPITSKMGKIIAHFKDRNIKSWQLKKNGYDIGHRGAGCARRIDSCEKVLENTIDSFNFAFKKGADMVELDVQLTKDKIPIVYHDFNVNIVLQQASLMSIKSILDIPLSENHMPENFQMNIKDLTYEQLQKLKLRPLQRHGKECYDFDGDDVDSPHGLPFASLQTVLKSVEANCGFNVEIKYPQKKINGDWEAEKSHDLNEYVDLILQDLFLYADDRKIIISSFHPEICSMVKLKQDRYPVLFLTQGLSTKWMKYHNPLNHSIEMAAYLALCMDLYGVAVHAEDIIKNSTLIRFVKSKSLVLFCWGDDLNDRELIKNLKKEGIDGAIYDKIDLLIAKPESHENPNCEVSPPISLNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCQ7</accession>
    <name>A0A922LCQ7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytosol aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.1</ecNumber>
            <ecNumber evidence="5">3.4.11.5</ecNumber>
            <ecNumber evidence="11">3.4.13.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cysteinylglycine-S-conjugate dipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Leucine aminopeptidase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Leucyl aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Proline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LAP3_1</name>
        <name evidence="21" type="ORF">DERF_003810</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Derf</strain>
            <tissue evidence="21">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Derf</strain>
            <tissue evidence="21">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-cysteinylglycine + H2O = L-cysteine + glycine</text>
            <dbReference type="Rhea" id="RHEA:28783"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:28784"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>S-benzyl-L-cysteinylglycine + H2O = S-benzyl-L-cysteine + glycine</text>
            <dbReference type="Rhea" id="RHEA:62568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:145802"/>
            <dbReference type="ChEBI" id="CHEBI:145803"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:62569"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an S-substituted L-cysteinylglycine + H2O = an S-substituted L-cysteine + glycine</text>
            <dbReference type="Rhea" id="RHEA:60444"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58717"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.13.23"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:60445"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="4"/>
    <dbReference type="EC" id="3.4.11.5" evidence="5"/>
    <dbReference type="EC" id="3.4.13.23" evidence="11"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCQ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="20">
        <location>
            <begin position="401"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAH9529962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="560" mass="61102" checksum="377B8B0529503B81" modified="2023-02-22" version="1">MLNCLLKQSSNRIDAIIKPLVFKRNFTIQNSHLFLCCRQILNIRPIIQLNNNQKFAIHTTTSSLIMQKNKATLIGVFENSNNKDAFVFTPSAEKVNSSIGGIIEKQLNIVGPVKKCKVRILYDVSPELPIVGVVGLGPENAAYNELEELDEKAENIRSAIATGVRSLRDLGSVEEINVDGCLNPKAASEGANLGLYYFDELKAAALKKSQVKLHLLSNEISDESQWDSGVLLSNGQNLCRNLMENPANIMTPTKFAKIASDTLSKLGVTVHVRDKAWAESMKMGSFLSVAKGSDEPPIFLEVMNVHYNNAPDTKPLVFVGKGITFDSGGISLKSSSNMDKMRADMGGAANVLSTIYTLASKKSPVNIIGLMPLCENLPSGRANKPGDVVTAMNGKTIQVDNTDAEGRLILADGLCYAHQFKPFLIMDIATLTGAISVALGSSATGVFSTSNKYWTMLQKCGVETGDRMWRMPLFNHFTKQTTDSQLADLCNIGKYAGQGGSCIAAAFLREFVTCNSWVHFDIAGVMDNKDEVAYLSKGMSGRPLRTLVKFIEEIFENKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCS9</accession>
    <name>A0A922LCS9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ATG4A</name>
        <name evidence="13" type="ORF">DERF_001041</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCS9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11 13" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="12">
        <location>
            <begin position="57"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9526990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="462" mass="54380" checksum="121CE5417FD3EF1F" modified="2023-02-22" version="1">MKMDIYSTLNSLAPKITNLNRDFNNHGSTDENRKDFPPTDDPVYILGKKYSSLHELNEIRSDVRTNIWMTYRRNFQPIGDTNFTSDSGWGCMLRCGQMVLARAFINLYMGRDWRWNYANLESIKQLLDHDGQEEEEEDVKRKIDEELEKYLIYKNLLKMFNDQKTESYSIHQIALMGVCEGKNVGQWFGPNTIAQVLRKLSMFDKMNDIFIYVAMDNIVFLDDIRKSCKISQNDDYDDDDDDETKCQEQQKMKTLKKWKPLILFIPLRLGLSEINPIYFRALKTTFTFPQTLGILGGRPNHALYFIGCCGDDLIYLDPHTTQSNVHIVAQDREYLERLLQHEEQMMIIDDIDDQLTTTTSSSLNQRSADDVSYHCERPYRMSISLLDPSLALCFFCKNEEEFNHWHQLMMGKLFHEQTQPLFEIMKSRPYEWQNDEDGDDLDCIGSTSKIYSWIIFKKFTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKZ9</accession>
    <name>A0A922HKZ9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_016010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKZ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22383">
        <property type="entry name" value="KH-I_Hqk_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032377">
        <property type="entry name" value="STAR_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF125">
        <property type="entry name" value="KH DOMAIN-CONTAINING RNA-BINDING PROTEIN QKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16544">
        <property type="entry name" value="STAR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="232"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9491278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="575" mass="64445" checksum="5085E6EDB188CABE" modified="2023-02-22" version="1">MMSSLNDITTTIMNDDQQQQQQSIKDQDLMVKKLLNFINEDDDNDNVEQQKQQQQDKDLNIETKMKNDTNNNDVIISVIKNEPDDDKDDDQQQQQQQQVDNDEQTIMTTTNGNTTNINGDDDDEIVVNNNENITLSIMTTNVTTTSTTTTTTSSSLSINPLDKITQRKSLDYLKELFNDRERLSLMPIGIFSHALRLLDQEIVRVRTSLIHIDGSADERKPLQLPEPDGAIIQRTTRVSIPVDQYPEHNFVGRIIGPRGLTIQELEVDCGCKLYVRGKGSLRNKDKEEKLRGQSNWEHLNEDLHVMIVVEDTINRAEIKLNYARDQIQKLIDSVIMQKDDFKMRQLAELAILNDKFNMKKSSIKNRNQQQLMTNGHLVSSSSSSTALSAAATTTTSSSIPNCLLIDTTSGSFVGGGGGSSNHTTSHHQTSPQTLAAAILNHHANQLIGSTTSQYQPQQQPPPPPPSLSTTIPPSSLNLEQSLFTTNQQLQFAQLAAQQQQQQRYQTNAFNTDLFAIMAAAAAASGGGLYGGGSTAIDPSIYSIYNNNNNYQNQQRQSRYHPYHHHMNMKRKHHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLB9</accession>
    <name>A0A922HLB9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLB9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037977738" evidence="1">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="81" mass="9491" checksum="440C460A545EFC19" modified="2023-02-22" version="1">MGIKILFCFVITKIECCVCFEHSCSKCANSQFLNIRSLIPVVNREIQKFFFVLFFVTSMMTNTIENWSNILFAFQSFDSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HM23</accession>
    <name>A0A922HM23_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HM23"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="108" mass="12706" checksum="A372ADFFEB6F67C2" modified="2023-02-22" version="1">MIRARRQEYIHRRNNNKNLWPQKYKNYHHRMVQFINDGGLCCMVHIDDDFFINVFLVRSNTSANLSQCLCTYESFVLTIVAVTLFQSQYNNLTPPFTGTFPPPSSRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNN4</accession>
    <name>A0A922HNN4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNN4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="528" mass="63627" checksum="95B75D015361684F" modified="2023-02-22" version="1">MSINTIKIFLFIQIFLSQKREKNLTVSHQFQMKLYVEISLINMTTIIKIIKRNLSLSFLRKDYHGYINDFINDQFQMCVLLLLRMDFSITDYREKRIRRNLKTFQPTLWITTNAWISFGLLIYILIFPPNDYTIDLKFLEQLMNCQRFDLIVCQMIIAHLNVEWLWLVMARRTLLYRCSWVDFMTIDHSDDEQKLDRKIRKYMNKFHPLMNFITTSVYLVIVIIMMTNVILLPYYCLQYYQDGTINFIQYLTLFLMIPIYIDTEQMLGQLFVATKFQLFTLLFFNGRIKRLHSILLSLVCHADYPTYISEKIFWNRFHNEYIILHDEIKQSNETTKILVFGVEIISKSAILLSCVFYSCQSKMVLVGYLFILFAIIGIFFLYGLYYQVASLPTHNEQCIRALSRWLARTQWSTRFMLQGKSRWHKNHPIKWRQSIKANLFVQMMTINRFGYTCGNLFEINKYKFFQLMLWNLPFILIIQYTIRLMQKQQNKFNTYNTQLLMWRKSLKSNLFVQTMNNNRLGFTCGHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNQ5</accession>
    <name>A0A922HNQ5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNQ5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="98" mass="11291" checksum="62BA0C6D6968026F" modified="2023-02-22" version="1">MISWRCLVDSVRSLLFLCQMNTDFNLTLFVGFVHGDFKLINIDSSQLMLKIVVFLLILLFSMVVVFVFNLLILSFQYRSCEYFVRFGGAYVVAVDGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP30</accession>
    <name>A0A922HP30_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_011969</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP30"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000011">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="11">
        <location>
            <begin position="53"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="12">
        <location>
            <begin position="141"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9501100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="393" mass="43912" checksum="6499C3A4384A7184" modified="2023-02-22" version="1">MKIYPGCFRGVVHDFDMMMFEGRFSEISMQNITSLESNAGLLARYMALRQPENVVQAMYVWIDGQQGLRAKTRTLNFVPKSSSELPIWNFDGSSTYQSEGSNADVYLFPVQVYSDPFRGGNNKLVLCETIRYDKTPTPSNTRHTCNAVMDMAADQEPWFGIEQEYSLLDGTDRNKPLGWPTGGFPGPQGPYYCGVGANRVFGRDIVEAHYRACMYSGVKIAGENAEVMPSQWEFQVGPCKGISIGDDLWMARFLLHRVAEDFHVAVTFDPKLIPGDWNGAGAHTNFSTKAMREKGGLAEIEAACKRLEKNHAKHIVKYDPSGGADNARRLTGKHETSSMDKFTYGVANRGASVRIPRQVADDGYGYLEDRRPASNMDPYVVCEQLVRTICLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPW8</accession>
    <name>A0A922HPW8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPW8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="392" mass="46408" checksum="527858D8F77EBC5F" modified="2023-02-22" version="1">MDTVQVYFTDLESYPPVRDVYWKDCEFTMMNPFLTEEDIVNPKFPHDGSDHYFVIKIMKLIPTAHSRLIQEREPNRQHPFHKDNTKMIQLSNIRELCSYSPSVLTFQIEQRRIHYRIEFSSDEKLKWLIGCIMTEIHCFTWDQQLTNLRERRYVVQNEILWKKYYKPIELPRHCQIDDDDDDEVTFDIREKNHRTQSSESQSLNMQQIIESWAAVKNSSKSLLPPSSSSSSHSSAFNVNDNDDAEEKKEADKNFEYSNMDNVVDHFWCEEDMDDDVVFNDDEFDDDDDFFYDDESEISAPETFIDDDSDEDENPFFNETDDDKTIVNGDHSDNDYDMKSLIDEELNRHIVDPYLSPSVEHAFQLMCTGFLFMMFYHLAYLAAFYTGGDTELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HR05</accession>
    <name>A0A922HR05_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HR05"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="817" mass="97883" checksum="A94ADD1987E23E19" modified="2023-02-22" version="1">MKHIVEENGTVRYRLLHIVDVSLYLYWLIRDYVISLIFIIQNYFHYIDMIMHHCISGIIENILNKFFALILILFVFTGLLGMRTFFFNNVNKHGFQLIYDCIVRNTDQYYKSRDTDENIAMKLSQRFEDYQQQFARNHRLLSQITPIANRMVSFKVWRDSWVEMDRRNYILLFVLIMDFCNYCLHIFILLKELRFIHIEHNTLSYYVLHGDKTTWSQPLYYYALVSIPINVLFMCELIFEDMPAHTEFVFILIALIHVITGLIPFITLAHVSSAFHKIKDYIPAMQLRLNRSTHLRMKLKYDDLYERLMSGKKIAFTFGYLGNLTYRGLRKNLNVKMLFKIKTFLYDALKHIVEENGTIQYRRLHYADLVLYLYWLIRALFISLIYIDPERFPLYRYDYASLYFWDHRRILNKFFVIIIFLLIMIGLLCIKTFYFPKQHDDDELRFQVLYDCIVHNTDQYYKSRDTDENIAMKLSQRYENYHQQFVRNHRLLSQITPIAKRVVSFKVWRDSWLEMDRVDKILFEKINKMKLFPYATFKGRSYIVLFILFADRVNYIGHLLYIFVTPIAVPIVLYQLFSYELVKNSLWMKITLMIETTIFIYNAFLLIQSAMLLACTIMSTYQAFHSGLSYLNQMFVSILDKSRHHNGKQITRKDVLNLGLIYRQHNKLSYYVLHDDKNTWSQSLYYYALISIPINITLLCELIVEDIPAQTEFVFIVIAVVHAITGVIPFMALAHVSSAFHKIRDHILPMQLKLKRNYLRTKLKYDDLYERLMHGKKIAFTFGYLGNLTFRGLFEAFLSYIAAFFLIMGFYMKEHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HR67</accession>
    <name>A0A922HR67_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Gamma-aminobutyric acid type B receptor subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">GABBR1</name>
        <name evidence="20" type="ORF">DERF_010587</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HR67"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000072">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF77">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="19">
        <location>
            <begin position="526"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="740"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH9505816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="862" mass="98286" checksum="3C384FD26E3E5A7C" modified="2023-02-22" version="1">MSSLSSSSQYSFAKRKPLDKSKLKYIEIGGLFPMNGTTGWLGGQGCLPAAMMALEDVNNNENLLSGYYLNITWNNSQCDPGLSSAVLYDLIYTPPNKTLILGGCSIVCSTIAETAKMYNLIVIGYGSSSPALSDRKRFPTFFRTHPSATIHNPTRVKLFKKFKWTRIAIIIEAEEVFVTTGKDLEIKCKEADIEIVTRVSFLDDPTEAVKSLARQDARIIVAMAYGGAARKMMCEAYKNGLYGKQHVWFLIGWYEDNWFHPSTGINCTMDEMMAVVEKHFTTEALMLNQGPEITIAGMTAKDWLHEYQKQLPKYKEWFPHGEKPQEGFQEAPLAYDAIWAVAFALNRSIARLDELGMSLDDFDYEKKEITDIIKSELQRVQFLGVSGDVAFNDIGDRISWTLIEQMINGTYQTLGFYDTATDNLTWYDREQWYISGRVPKDRTEIVPTLMTVNRTLFVSISAVAIIGILFAISLLCFNYKFRNNRFIQMSSSSSNNIMLVGCIFCLISVQLFGLDGQDIGIDYFQVVCNSRAFFLSIGFSLFFGAMFAKIWTCHVLHTQNKRKINNNQSYLIITVFCTLDIIILVIWYLYDPMSRRMEYFPLEDPPSTIDDDVKFQPLLEHCEASLIWYGLLYGYKGLVLFFGLFLSYETRSAKLKQINDSRLVAMSIYNVVILCLITGPVSLVIDNQVNSHFAFIGLTIIFCCILSMALIFVPKIVAIVQHRQNLGTGMNNTFNETMSTKEEEDRFLRLNTENDELKMKISEKERQIEEVKKRIEQLSKEQMERKRLEEKDKTQIKTILKKAVRIQEPEIENHNQMMANTTMTTATNDIINMDITSDSGFQTSTAKTLSKLSENDFSESYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRX3</accession>
    <name>A0A922HRX3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011278</name>
        <name evidence="1" type="ORF">HUG17_7119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRX3"/>
    <dbReference type="OrthoDB" id="6486020at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7636913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="119" mass="13840" checksum="7C8080C7B9559277" modified="2023-02-22" version="1">MDESVQFEDKIIEINEHRIKLQFIRIYQTFMVWIGDPSCPKLESLALALGVNSTSIIANRQQLDSVADQEMANKLSRRFNDNRPVYVAYNYLPAMANTELKLKIDQQLIEFIQSIHHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS85</accession>
    <name>A0A922HS85_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="13">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GAPDH2</name>
        <name evidence="16" type="ORF">DERF_011093</name>
        <name evidence="15" type="ORF">HUG17_5879</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="13"/>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS85"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019682">
        <property type="term" value="P:glyceraldehyde-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000266">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="14">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="148"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="11">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7643517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9506355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="332" mass="35697" checksum="C963F4CADB7A1D4B" modified="2023-02-22" version="1">MVKIGINGFGRIGRLVLRAAVKKGVEVVAVNDPFLDVKYMVYMFKFDSTHGRYQGEVKEEGGLLVVDGQKIQVFQERNPADIPWGKVGADYVVESTGVFTTIEKAKAHLAGGAKKVVISAPSADAPMYVMGVNHDKYDPSQQIISNASCTTNCLAPLAKVINDKFGIENGLMTTVHAVTATQKTVDGPSGKMWRDGRGAGQNIIPASTGAAKAVGKVIPELNGKLTGMALRVPVPDVSVVDLTVTLKNPASYDEIKAAIKAAAESDHWKGILEYTDEEVVSSDFISDTHSSIFDAKAGIALTPTFVKLIAWYDNEFGYSNRVIDLIKYVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSH3</accession>
    <name>A0A922HSH3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">28S ribosomal protein S21, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MRPS21</name>
        <name evidence="4" type="ORF">DERF_012659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSH3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9501848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="99" mass="11958" checksum="26E58F5F87EFF3D4" modified="2023-02-22" version="1">MFLSTICFSRSRMLNRFVGKTVIVRDGDVDGSIRVLNRIMGSEGLFDIYRRTRYYEKPFNTRRRVSWQMCKAIYDEDMERKIRFVSRKNRTNPNPAYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSR5</accession>
    <name>A0A922HSR5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable prefoldin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PFDN6</name>
        <name evidence="7" type="ORF">DERF_011292</name>
        <name evidence="6" type="ORF">HUG17_7107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSR5"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7636901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9506566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="125" mass="14511" checksum="1E5020E3ADD2CBB6" modified="2023-02-22" version="1">MDVKQQITDELNKFQAIRNQCKKILSQRGQLEIQLNENKLVKEELDLLEDGSKTFKLIGPALIKIELKEARDNVNNRIKYITEELKRYDQTLETLTKQQDKHRDAVMKLEQATQQAMSAVASNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HT74</accession>
    <name>A0A922HT74_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TOP2A_6</name>
        <name evidence="8" type="ORF">DERF_012935</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HT74"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9502146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="548" mass="62321" checksum="0491AA9EF7F1ECDE" modified="2023-02-22" version="1">MYQRQIGIKRGKSNDQIMDTANKMQRQLGGGYMNSGSNDDDENEPVIDDQDDQREILSTTINYGQRGKTTSTPYNPANSNPNTTSGSSNSSTNSSVISRPSLTTKRDIEFVRMTLEEVGSIGNTIDEFTKKRIIASLEIVLLLQDEVLEAYSRLDAETNLRRQLKKSKLNDETEPLRNEINEIKSTMMMMNETMMKMNQQQQLTTTIIENQPALPPPPPPQSPTTYSGILKKAMASCSNDPCLKTVVTITGNDDAELTKREITNKVIPAQHGIRIKDTVKLRDGKFLVNFKSPSSKRKFENILAQDGKFKYSDSGRLQPTVHMKGLSVAYQEEMIPGLIALYNPEIAKFLDESGLEVDKVIEVKKKKQNPAKPHLCNVIMKVKPEIRNILINELNGRVNIEYSYIHVEDMSPLRQCFHCFGFKHIAEYCPRKNRQICLHCGGEHLISECMNREDAPTCLNCRIEQLPSQRNHMATSRDCPQMWVYASQDGMVLRDVSYVPQLYKIFDEILVNIADDKICDQKMTIIKIEINMESDEIIFLTMAVEERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HT93</accession>
    <name>A0A922HT93_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_010746</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HT93"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042302">
        <property type="term" value="F:structural constituent of cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057475">
        <property type="entry name" value="CUT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051962">
        <property type="entry name" value="Cuticlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22907:SF54">
        <property type="entry name" value="GH04558P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25301">
        <property type="entry name" value="CUT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="10">
        <location>
            <begin position="148"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="436"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9505984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="550" mass="63077" checksum="AFD64E2BAA6BE4DF" modified="2023-02-22" version="1">MEPYEQQQQQKQKPFHSCGHHRRSSSNKMLKSNHRFEMPNYHHDHHQNDEYGRRKLPIFSYYHYHHHHHHIIVSANSIVGVHVEHFPNTATANSKLSNSNPLGNHNINIGKAVFDQRSNEIPSSSAAGTPAVSIKPDLFGLITEVNVECNSNAIHIALIAPHLFNGMIYPKGLSKNSSCMHEYYDVNEFNYTLPLRACNTMSMDVDDGIEYFNTVIVQPHRRLVTNQGRGYHIRCQGKTETTPLYGTAPVPTSSMKIYHQGTQKEIIADNVKIGDRLTLTIAIEQQDIYGMKITNCLVRDGLNWGEQPLINDEGCPVDKEIMGPFDYSLNLTRASVSFHAHKFPYTSSVYYQCNVRLCLKDEIDGCTDVPPSCDQNGRNYRHLPGHQRRQRRDTYDAVVIPDMNHQQYHRAMAQRMRNTKMDKDLSMEVYSGLYVDENENNTPELDDEESETSMNGDNDQDRRHGRNHHNRHHDPNEFCISMRKFAIGVAIASLLLMLAVLLLVICILQRRRRRHHQQHQRFYSQSAAGSTIGSGSVYSGPYTNRGYIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTC9</accession>
    <name>A0A922HTC9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">JAK2_1</name>
        <name evidence="15" type="ORF">DERF_010670</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTC9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005126">
        <property type="term" value="F:cytokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051286">
        <property type="entry name" value="JAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45807:SF7">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE HOPSCOTCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21990">
        <property type="entry name" value="SH2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="578"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="969"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="893"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="996"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9505904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1244" mass="145027" checksum="31698B25EC2010D2" modified="2023-02-22" version="1">MGQSTSTSTTTTTTTTTTTTKSPSPSSSTTSTSTITSSPQPLQQTQPESSSSSSASTASSIKINVFDFNKNDYHNITISAIMMRMVTDLVFYLTSSLKITTICSHLFALYNVESDLWIAPNQQLRTMINELFNNQQQNGNNDNGPMLQFQLRIRYTHSNLINKLKLLIIIFYKSVMIFYIYRRKKFKKDELEEVFGIALIDLIRVTIEDDEKLRNAYERCDSYISQIKKYCPKNMVKPKLLFIDDKLKQTFRRNCQKDTNKIWVKWCYIKQFLSRSHSFYNLSTMQMAYSFHEIYDIILESSINLTSIPTQQTISEHLVHYDWKEQKICWRKSSSSSDYNNSNNTSTSTSNKFNNNHDEWKTWFSIEEISSINILSLDRRKILICFVNRPALTVIFRRLGQMKSFISLLSGYHRLSIHWNLNLSAEYFSPMLNKLRKINCFGPIQDEFAIKRLKKTRDGQKNSGLFLLRQSETDFYKLKLCYEQQNEMKCFELKWQPSQSSDNSLFVWKDDFNITDVRVDYSELLIWLQKQLNLFQPILSGENDHLPDLLLCSHEDDINKLKSNDDILPIIQNERIKKSILTMHNNGVFCTRIGTVKLVGNQEEKVFIKEFIDSKESGRGENILKEIDEWSKLKNVAIMNCKGVVMHPLSILFEHCHITLRDYYSLQEFKLNHFNLTEAAFCLAKALDYLYTHNLRHGYIKFDNLYVSHFSKTSLFIKLGDPIGFSCDFNQTIEQPWLPPEYFNDNGFFYKKHTNYSDVWAFGTTMWEIFHNGNKPLFNYMNIDQVNLCAMPEPIRLLTKKCWDKDFCNRIPPSGVFRELVLILYEARKYRKQYILSNDGINDEMIRKMNIEKINMKSSYPTYSMKNNNSLGGSSTGIIDNNSMINNNGYSQRSSLPISNGYQQRPISLYDDDDDEDDDDDDDDDDMDDVTTETTLYDQMEDAFLISEKDDYLHIQAMDNLECIPQDRINVLKMIGEGNYGKVYQARCDDKYVALKVVSDNKISSLSEEIKILTKLRHRNIVEIRGYSNVDVDQYSKGPSKALVMEYIPLGSLVKFLETKGPNDNLEMTKFATDIACGLDFLASKHIIHRDLAARNILVASGNSVKIADFGLAHILEDDTQYEYRSARGLPYKWYVLHAPESFERHLFRFESDIWSYAIVIWEMYSYCRVTLYKEIDSNKDDVQELLTYLKQGKRLECPENCPESVYKLMLKCWAYQPECRPNASEVYMMIKEIDEQIRSQSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTS3</accession>
    <name>A0A922HTS3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-1 3/1 6-mannosyltransferase alg-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Alg-2_1</name>
        <name evidence="8" type="ORF">DERF_011834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTS3"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16183">
        <property type="entry name" value="EFh_PEF_ALG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF9">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9507135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="221" mass="26482" checksum="9263CC1312866056" modified="2023-02-22" version="1">MSWNNNNRHHYNNNPYYNNQYPQQQQQQQQQFNQYNLPHYPSYPQNQPYMPNQEWLRSVFDKVDKDRSGQISANELQGALSNGTWKPFNPETVRLMIAMFDKDKTGSINFEEFSHLWRYVTDWLNCFRSFDRDNSGNIDPSELRQALTTFGYRFTDSFLQILMKRYDREGKGHVTFDDFIQLCVQLQSLTNAFRQFDTDMDGWIKISYEQFLTMVLNIALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVN5</accession>
    <name>A0A922HVN5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sorting nexin-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SNX9_1</name>
        <name evidence="3" type="ORF">DERF_009082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVN5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45827:SF1">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sorting nexin protein WASP-binding" evidence="2">
        <location>
            <begin position="3"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9510558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="87" mass="10194" checksum="53CACA3337111FC0" modified="2023-02-22" version="1">MTGSINKKREHKKARDEGRLDDKSLMDIEKRADVVTYATIAEMNHFEQERINDLNKVMREFLTGQLKLYQEIVVNIENALQMFPPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW47</accession>
    <name>A0A922HW47_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine threonine-protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PRKAA1_2</name>
        <name evidence="7" type="ORF">DERF_009304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW47"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="244"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9510798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="545" mass="63675" checksum="FF58043BCB6520DE" modified="2023-02-22" version="1">MNSKTNNKTNDEVVKITDMMADKVESYPSVYYEIKEKQPIDHKSGLVIKFMSNEKSMIDINNENQMKLVNVRPAIDKPLIDSSSNDGKNIPVQMSLDESESSVADLFVTRSELLAEENVPSIIGLQDNDKNVKSNILEANQCYSQQQQQQSSSIIETHKQFQTRGPKLELTLNKVRKAIENLRPSKPISPLPPSSSSLIIDSSWVGQNSARFKWIPLQSMEEIRKNWLEWNQKQESACILMDENSLTVVDGDDQFATYYDRYHKLFASKIRGTAFYLGRFRNHHPILVKRITTERKYFDLDATWIAITKRICSSSSSSDDNNPFIRIYEIFHSPSASQVFMFMELLPNKSLHYHLRRRRSIRIDEISLWSSQLLNAIAFMHNHAIVNRSLRLEHLLLDEKFNIKIINFRRSISYWIPGSTINRQQVNRISKREKKCRQNNHLPPECFHNNYDPQSIDLWSFAVIVCSLVTYRYPFKCMSKQIIRNMEQCWLDFKQRHQSLFITTTDSIRILEQIAEMISMIFKQDPCKRANINDVQKCSFYCNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWA6</accession>
    <name>A0A922HWA6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein sap1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_010098</name>
        <name evidence="12" type="ORF">HUG17_0128</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Positive regulator of amino acid starvation-induced autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SCOC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWA6"/>
    <dbReference type="OrthoDB" id="2163284at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019357">
        <property type="entry name" value="SCOC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614:SF0">
        <property type="entry name" value="GEO08385P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21614">
        <property type="entry name" value="SHORT COILED COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10224">
        <property type="entry name" value="DUF2205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="49"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7644590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9511649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="182" mass="20697" checksum="1DA48068952CB77B" modified="2023-02-22" version="1">MSTKNKLTNDNDIIGNDEIPLADGDDTIEVTDMDMMKLNLANITGKEKLEQLQQQQQQQQRRRNSDVTNLARPESPSGTIRIHHQQQPNSLDINHELNPDEMEEKERMIQQVLELQNTLDDLSLRAESVKEENLKLKSENQVLGQYIENLVSASSVFQSTSPKQRSGGKNNNNNNNNLSMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX64</accession>
    <name>A0A922HX64_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX64"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9510874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="169" mass="20160" checksum="DEEC824B35A78ED7" modified="2023-02-22" version="1">MNKPKFEKKSYEEDSDQLFDELQVYGKLYRLETEITRLTKENATLSKDNETLRKQISIKDGQLKVLKNNISSLYKTAKLELDRRLSEKQELQNQYDALVFRKIKNFEIQRQLQQQNIHSIHDNMVTPDSVDCDEKLRQNNKRKKSFHNDKNVSINNGHGYKWKRSPSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXL6</accession>
    <name>A0A922HXL6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DDX55</name>
        <name evidence="12" type="ORF">DERF_009585</name>
        <name evidence="11" type="ORF">HUG17_7453</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXL6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="35"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="254"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7637247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9511114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="595" mass="68993" checksum="369C7CEA580D4DB0" modified="2023-02-22" version="1">MDSSWDSLNIDAELKKIIKNEFKFETMTPVQAASIPLFITNKDLIVEAVTGSGKTLAFVVPILQILLRKSQTETIKKHDIGAVVISPTRELATQIYNVFKIFIDHSEEFDFKLMLLIGGSNTDKDIRNYGNNGANIIVSTPGRLLDILEKSAIFSSKIRQCLEVFVLDEADQLLNLGFEKTLNDIIEYLPKLRRTSLFSATQTKELNQLIRVGLRNPMKVEIKEKNLKKLKPNQLQMPNRLMNKYMIFESAEDKLPFLIDFIRQHPMEKFLVFISSCAQVNYFERILNRHLSGNNKILLLKLHRKLKNKRQKIYDQFRETSHSLLLCTDVVSRGVDIPQVDWVIHFDLPLTIENYVHRCGRSAHQINTYGNSLLFCLSHEIPFIDHCKTRGIDIQQYDDQNELKSDLQQLKESLFKWIRSESKRNINFYQMSTEAFVSFIRTYSTKHIMAKWLFKDCDVIDIANGYGLLTMPKMPELRQAKKCSTQFKGSDEDAKIVGKFKQILYDKKIKNNGLGPMSKTETNAKKRLGFKRNPQIAETIRKVHRNKTMKGRTKKIIFDELDVEELNSDARMVKKLKKSKITNKEFDDYFGLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0T8</accession>
    <name>A0A922I0T8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0T8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="94" mass="10495" checksum="67A792516862A75D" modified="2023-02-22" version="1">MSSSKRFTLSMESENNIMCRAFTRSPNVLAVLAPADNAKSSALTIFRDLDLRDHPIRSPISMIHVSSFSASRSLPTQIRMGRKSMRDTLTKPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I137</accession>
    <name>A0A922I137_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I137"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6415" checksum="9B59F4EA7681C666" modified="2023-02-22" version="1">MTTFSDNFCPPLDSEVVAAIISSRDGFSLNTSRSNPVRTPSSAVAEEFMAESSGSRLVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1G9</accession>
    <name>A0A922I1G9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1G9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="161" mass="19572" checksum="673A844273C7CCD1" modified="2023-02-22" version="1">MALSMDRIDVQLRREQFRLFQLYQQQCWIQNRPIKVDQLLSLINQCARPHLMRADFIPHDIFPYHFDRINYECLNGFVSPQWNICDQFVLDSMMKCWLQPKDMAIWFRLQLLYQWNRDSMATLVEQIMNDCTYLLEMINKKNMDENGNNEIVDKRNQTKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I286</accession>
    <name>A0A922I286_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I286"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7238" checksum="661EF02F23274C7F" modified="2023-02-22" version="1">MHQVLKQQESTWPFDQPRTKNRKDSLSTLHQAMAGSSSIHKTMTSSTYSSSSSSSSTTTAKATSGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2I0</accession>
    <name>A0A922I2I0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2I0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="69" mass="8084" checksum="E59C54214D72F827" modified="2023-02-22" version="1">MIILVLYYISNSNNNNDDLVLHRDKKKARISSPIARLHHHHFLYFWPTTTTTANTAAAAIWKMYPDCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3T2</accession>
    <name>A0A922I3T2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3T2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9518003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7878" checksum="D6D83D75EE607C7A" modified="2023-02-22" version="1">MMMIKDLGQECPIIMICGPVHYYPCNVVEIKFAHFFLDEESVMFILDSVFLISITEMYTIRDRFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3U7</accession>
    <name>A0A922I3U7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3U7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9518132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="490" mass="51107" checksum="6FA03141447083F3" modified="2023-02-22" version="1">MRSISNESQLQHQTGLGVGSSSSSAAAAATAAAAAAAAAAVGGGGGGLASTITATNSPIWSSSSLTPSGYDFDIYNTSTSSSTINGSHLLTKNNSLSNQLIDSYSSSSSTTGNGISTQGGSNNNNNNVNANNSHLNSSSSSAAAAYSSSYGSYGSTTNETAAATALAVASRKQAANIGINNTSSSSSSFKSASTSSFWSNSYDSTTMINGGGGGGGPNMASSGSLSTNPSPHSHHHPYASPHGHPHPHHHQMANDPFASFAAAAAAHHAVNHVAAASAAWCGYPNPYHHSHHSHHHQSTRNDHHLYGLKTDTSNEHHQHHHLYGLKAEPPETQPSTFTMDPNVTVISPYHTAMQRMAAAATTQSTTVNNHSSDHHNHHNNNHHLHTNQPPPLPVPPSSWSPNGSSSQNGQQNNDHCNHTKSISTSPNIVTTIDQQQQQQATNSNDNSTTNMNGDNNNNNNDNDENQTNINNNNNNNNNNTTSNSECDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I431</accession>
    <name>A0A922I431_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease</fullName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RNASEH2A</name>
        <name evidence="12" type="ORF">DERF_005741</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I431"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="29"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9522142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="315" mass="36224" checksum="763660F759959543" modified="2023-02-22" version="1">MFDLSVFFRDPSQIHHLNSAIKTCQTSEGVIVGIDEAGRGPVLGPMIYAAAYCPLSMRAEIEKEKYQDSKTLTEKQRSEMFETIDNDVNIGWSSTILSPIYISNSMLKRSKYNLNAISHDSAISLIRSIQAKGIEIREVYLDTVGPPEKYEQKLRQIFPDIAKIKVSKKADSLYKIVSIASICAKVLRDHLIKHWQFQENLSYNENDYGSGYPNDPKTKEFLNKVFDPIFGFPTFVRFSWSTITKIMDDKAIVCDWDDDDDDDDQDENNYSKQSIMNFLKGKKNFDEQKSKILKSSNFFTEHDLEQINDLDRIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I433</accession>
    <name>A0A922I433_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I433"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="236" mass="27195" checksum="F1C079EE6412ECBD" modified="2023-02-22" version="1">MNEQYFGMDVGILIKPDVGNNNMQNIYEYHRERMMAHISSTLCAFFLFLMFIMIEQAQFLEFNNYDDESLDSERPSALRYHLPYEHRLYDDIYDHETSESQYGEYSPDMALNEMDDYVQQSESESESDSSPYSSFDNDNDDDDDDDDDDNDNDGDDNDDDDNNYSSSSKPKNTESSTSTTTTTTTTTPVLKSDQIISSPPFQATQSVAVQEINTKSGHFRWRILTDMNAMKSTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I440</accession>
    <name>A0A922I440_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I440"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="138"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="234"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9518267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="432" mass="50086" checksum="3EB7FE75A87403F9" modified="2023-02-22" version="1">MSIVECNVWPKKIEIVNSNGEILNDRIIGPYDQGTDLTLICLADNDPFIHTSVIWYDENNTKIDSTFCTESNGLWIRNELILKNLTYEHLNAMYICRGWNSHDDIRKHQKYIPTYIQLNVNLRPRQIRIVLTRESMYPTSKMYDNDSLILIADHLVEFECIATGFHPSIEIHWLLRSKNSQLIDIDLHTNTPIIQFIPRIEYDGNLLICSAMNLKMVNNSESIVIQPIRVYYKPRLTIMPIGDDLLEEGSDLRLQCRIEANPDVFYEGIIWIQDGQVVWKTLSNDNDYNHNNGIVEATKIFRKLTRAQNGSIYQCMAANEIGQNISEPFMLSIVENRRNQSFIKFVDNNYKNELFHGTSSSWPILHKNNSNSHWIRLDNHILAVSLAISILTLIIIIIIIFVIFPFRYCCHSKQIDTTNENNACTVVYESSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I474</accession>
    <name>A0A922I474_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I474"/>
    <dbReference type="OrthoDB" id="10528982at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037364746" evidence="2">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="142" mass="16454" checksum="C87F5B850308F391" modified="2023-02-22" version="1">MFKLFTFVSIMMIIMFSTAECRVMLKNNDNNNNNNLDLDYAAKRLRLDKDTLSFMNEYNRHVRNIRKDVFIDTFEKSPAKIHQRSISDQSKHPYGGGINMRSIMNVFTAIGMILALIFIIILMIMASKEFYQTIDTAVATII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4B2</accession>
    <name>A0A922I4B2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4B2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF360">
        <property type="entry name" value="CHITINASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036882337" description="GH18 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="29"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="448" mass="50470" checksum="5520EF93F37C92BC" modified="2023-02-22" version="1">MTRFSLTVLAVLAACFGSNIRPNVATLEPKTVCYYESWVHWRQGEGKMDPEDIDTSLCTHIVYSYFGIDAATHEIKLLDEYLMKDLHDMEHFTQHKGNAKAMIAVGGSTMSDQFSKTAAVEHYRETFVVSTVDLMTRYGFDGVMIDWSGMQAKDSDNFIKLLDKFDEKFAHTSFVMGVTLPATIASYDNYNIPAISNYVDFMNVLSLDYTGSWAHTVGHASPFPEQLKTLEAYHKRGAPRHKMVMAVPFYARTWILEKMNKQDIGDKASGPGPRGQFTQTDGFLSYNELCVQIQAETNAFTITRDHDNTAIYAVYVHSNHAEWISFEDRHTLGEKAKNITQQGYAGMSVYTLSNEDVHGVCGDKNPLLHAIQSNYYHGVVTEPTVVTLPPVTHTTEHVTDIPGVFHCHEKDSSAIRPIVPHTTNAKKAILDWRKPCIIVPITYRHLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4C0</accession>
    <name>A0A922I4C0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005864</name>
        <name evidence="1" type="ORF">HUG17_3217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4C0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7639184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="240" mass="28153" checksum="708479D0D6634F4E" modified="2023-02-22" version="1">MPHKLSSSPMNIRFGQKENEQIMNPDELHDDDVQQQSMNDLLYPIDYYYDINNNNDGMINDDQGLGSIIMDHPSSLVDYYLEQQQQPISEYYNQWEKRNQWNKFNGAWGKRAGNWNKLQSAWGKRLSPLSKIPIETRNWNNLKGAWGRKRNTAAVNNWNQLHGMWGRRRRTATWNKMSSAWGKKKRSIGMAAPTHWNKLRGMWGRKRSITPQETMEILGQQQPITITTTETPELTKTTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4V0</accession>
    <name>A0A922I4V0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SREK1IP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SREK1IP1</name>
        <name evidence="9" type="ORF">DERF_008614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Possible splicing regulator involved in the control of cellular survival.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4V0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31437:SF1">
        <property type="entry name" value="PROTEIN SREK1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31437">
        <property type="entry name" value="SREK1IP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9518011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="298" mass="34573" checksum="282A16ECEF39BD0B" modified="2023-02-22" version="1">MNQSNTNSVRSSCSKCGYPGHFTYQCRNFFRVNPTEDIVLDVSSTSSFDSDEGDTIGGGKPVAGGGGGGAEFDPFKKSKLKSKKIRKKLKKNKKHKSKRFSDDDDDYKRKKSKKVKCKEKRKKSKKLKKKSTKRYKHSDDSSSSSDDDSYDSDSSSSSSPDPRQPKRLKSKKYKLRDRSPNADGEWRKKRHPSISDPDHEFELASKPKIKSIANFPQKYQIPNSSEDDDHRKQRSRSTSKTRRRKHSPDDDRSRRHHHQRSSSKNHLERKRRSRSNSSGHDYRIRSRMQHRDIDDDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6L7</accession>
    <name>A0A922I6L7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GATOR complex protein NPRL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nitrogen permease regulator 3-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NPRL3</name>
        <name evidence="6" type="ORF">DERF_005306</name>
        <name evidence="5" type="ORF">HUG17_3649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6L7"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="4">
        <location>
            <begin position="643"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7639616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9521670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="713" mass="80561" checksum="96DF9F138DADD7BC" modified="2023-02-22" version="1">MMINSVDDLSRLNVSDETTPLGVFLVKSDSTEEKLLFRFPYVMIDEPIPSIQYNQNQYALIIPQDNNNITNLNNRTTNILNDSTTTQQQSSLLPAYTELTSSSISIDNNDKVEITKVIGLTDSAFSNLFGAVKRKLCDQKFELKVDNVRFVGHPMLVDKHCFHIVFALKADAQHDIVKSYHELSQHIAISLRSEEKRCKYFTKQSKIMISCHDEISVPSMAGDHHHPSGENAKQSSSTTAQLSPYKLILDKCQLANELKEIFLQLCNEGIVQLKMNQWINLNFCLPQKVHRRLMESPLAPPITPANIQLCLKKLRPYHTFLLLIEMDCLLQSLPQDVSPSFVRLIRVSNPLKNLLELSADADITLSQVFNIVAELVYWGKATIIFPLCESNHYMLHPSASTAIDSRFIAEFQQQFPCESLLRIMSKFSLGVSLSQFKNPMNSADQECKFVRMIVWMLRKRLLLQLHMYVLFLPLSNESPSSSSSSSSVTINTSSSSMMINKDNHNNRLIHNNEQQQTEPILLSDQISITNSSSCPTSDTCSPPSIAASPISSSNMMMTATTMRMAIIKELNETSPSSMMNDQHLNSNQQPLPPPPPPSLIVSNPSTIPSDTIPITDQSSFKESSELILKSIRLNDDEIQQVLAVPAADNIDDIRLFAKLVPYFDGHHHIEDIMYYENLRRSHIITLIDKFRDVLIVCHYEDTTVAELLPYNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6U2</accession>
    <name>A0A922I6U2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_006106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6U2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005335">
        <property type="term" value="F:serotonin:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015842">
        <property type="term" value="P:aminergic neurotransmitter loading into synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000401">
        <property type="entry name" value="Vesicular amine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9522542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="362" mass="38439" checksum="0B3F0FA849598726" modified="2023-02-22" version="1">MIFAVGSSYATLFMARSLQGIGSAFTSVAGMGLLADKYPDDRERGNSMAIALGGLALGVLIGPPFGGIMYEFIGKSAPFIILAMFALLDGCLQLLVLQPKVVREEQEGASLMTLIRDPYIIVAAGAITFANLGIAILEPSLPLWMMDTMESTNWEQGAAFLPASISYLIGTNIFGPLGHRMGRWLASMCGLIIIGLALLYIPMATDLSELIVPNALIGFAIGMVDSSMMPMLGYLVDIRHTSVYGSVYAIGDVAFCIGFTIGPVLSGTLVSWFGFTGLCTTSALISFAFAPCMLMLRNPPCTNQTTSKSQQTQLLNSQEGAVKYVSYTNDLDSPDLESSSAIGGGGGSLNNYSRNKSFDMVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7Z6</accession>
    <name>A0A922I7Z6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Salvador WW domain containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SAV1</name>
        <name evidence="6" type="ORF">DERF_000717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7Z6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21433">
        <property type="entry name" value="SARAH_Sav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000035">
        <property type="entry name" value="Salvador homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="728"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="763"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="5">
        <location>
            <begin position="1059"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="615"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="806"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="927"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1147"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="620"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="929"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9526651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1228" mass="135143" checksum="31FBDD671B5327E7" modified="2023-02-22" version="1">MVLPITLAVMPKKKDHHHHSSNYSNIGVAGKYTKKESPPNLPIINIWTSSSLSTTTNSKLSTVNNRQLNNVYSSAITAGVSHQQNSSISNLLASSFSTSITNLAFIGQQQPSPNVNNNNAKQQQSPQIQQQHHFHANSTSNLFNQHQNPTNSGSTIPNLSTKANHLTSTTADHCNNSRMTRASSQMTINNNGCYQVPTTGPIFASTSSKTTNSMMATSGTNNSQLKSTPSSSNSSLQSIHNNYNGQLIDSSPSSSSMTIMTTSSLTTNNNSAMYQSISGCRQQSFQRHGQQPQQQNAVASQIALRATSSTALGGINDPNIIVTQTTIPTTTTASNYLQLNHQHSKMWISQPTLRASSPSQSSSQIRSMMNLNQMVSGSVASNNNQPVGSSFTSNNCQNNPTHSNCYSNHQQQQLSNYVQQQQASHQIMLMNSLVHDFHKQQQQQHNASSNSSINQAIDSFPSNYYSPSSSLSSIHENSSTSITNLNSSQQQFSQLQSSSSQSSMNNYSPKTSNKQESNWTQQQNRMPISQQQQQAQHLYQNTSSCSSINNLANIMKSSSSSTGINHNNGSNTTLDSFAENMQIQMYHKQIQEQYSKQQTQELLARVLSAAATTAPNTYSQQQEQQIQPQPNVGCSTSSSQSSLSSLQSGPFKSSSNQALSIGVGGSNSKSNSNQNLTSCVSNSNLSMNTTTTQQMENASSPATTTAIAGSSCAIAVNNNNNNGQEESLPLPPGWSIDFTLRGRKYYIDHNTKTTHWSHPLESEGLPTGWERVTSSEYGVYYVNHITRQTQFEHPLAARYGQKLMPTTNTTTTNTSVGPSCWSNPQPSQSQQLTNPQQQHSQQHIYVNAANIQQLLNLSKEMAASLPKEENHTISDNHVYSNVHLLSQQLLQKHHQQQQKLQLTPLLENDGGSSASFLANDSGQYANTGNLNRLSSSELNNSSGDKSFDNQKMNPSSLPQHRLLSNALLRSTQLLNNCSNEQMDKIDHNVDGITNLSKSIEPICLPSPLRQHHQPSTALPLPPRPSRINDCIVPANPYLTEEIPHWLYIYSKAPPEHDHKLKWELFRLPELDCFQAMLNRLYRTDMERLVISYEIIRNALLREIERRTTENKHKFTAININDKNDNIPSTNKDKNNSALLSQLIQPNDDIEASESSPEPPPEFRNENHLTPSTTNSIICSPSLNSITIISSPSLSQSDNSTLTTTISPSSIPSFVSISHLFTAEEETKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8R0</accession>
    <name>A0A922I8R0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8R0"/>
    <dbReference type="OrthoDB" id="6509668at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="110" mass="13366" checksum="0DD538E1B82E568E" modified="2023-02-22" version="1">MLYFEKNWNTIMSKGMNQEIEEFIECMEKMKNQMERHVPLTVSEKKYKESLKKIGKNFENKREQLLNSCPKLNEHLKPGEQKKEHIHLSEDLLNDLAQFYEFQKLIKKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9A6</accession>
    <name>A0A922I9A6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9A6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9525900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="7440" checksum="5E67248977322535" modified="2023-02-22" version="1">MKFQYVRHSIFCQSKEEEEVEEKKFSEFNDFVYRKNVVKPTQEELEQRDVYFNKELNSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9I7</accession>
    <name>A0A922I9I7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynein light chain roadblock-type 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_000923</name>
        <name evidence="3" type="ORF">HUG17_4190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9I7"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7641146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9526865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="109" mass="12272" checksum="372C296FCD169EEE" modified="2023-02-22" version="1">MNEVEELLKNIDGQFKDVVGVLIVDRDGIIIKSTINEVVETIQNYGMSIAQIVEMSNQALKENGEIQFLRMKTKRNEFIVVPDKEFMLITILNANNPSLSHGQHALSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9U0</accession>
    <name>A0A922I9U0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9U0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="101" mass="11749" checksum="7A7E0460432251CD" modified="2023-02-22" version="1">MYAAMLIVDKISHFFSLLILQFYLVFFLLIITCELSILLNSIDSQHISGIVNDEIKMMMMNEKNKCYLFFGFEEKFQDCREKNSNQSQTVQLTSLLCSASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA03</accession>
    <name>A0A922IA03_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA03"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037002543" evidence="1">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="95" mass="11204" checksum="F98F097E38F4D135" modified="2023-02-22" version="1">MMMRRSIIITLSLLLLLLSLLLDNGQCKKEKSSSDNKFFNGDVEFVTLYYPIHPLVQLMYEQGYKGGYGTRYEDVNRGIIKNKKYRFKFYKPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAV6</accession>
    <name>A0A922IAV6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-fucose protein O-fucosyltransferase 1</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peptide-O-fucosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">O-fut1</name>
        <name evidence="18" type="ORF">DERF_001431</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 65 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAV6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11302">
        <property type="entry name" value="O-FucT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039922">
        <property type="entry name" value="POFUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420:SF9">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037112750" description="GDP-fucose protein O-fucosyltransferase 1" evidence="17">
        <location>
            <begin position="25"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9527417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="429" mass="50543" checksum="60A0CB34DE8E99C0" modified="2023-02-22" version="1">MSFYKMFAIFCYLIVLLFSDNVNSTGSDISIDPNGYLLYCPCMGRFGNQAEQFLGTLQFAKSIDRTLILPPFIEYVDYKVTFQPFEDILEIDPIREYHRVMTMQDFLSKLAPLIWKHENRSITCYSSRNFSNNEKNQGCNPFEGSPFKEFWYHLGVREFPLGSLYYKPLHTDYNYSNEWKQKFHNVPVLALVGAPSSFPTNSKAVKLSKYIYFTKSIMEKAQKYRDERGFARKPYLAIHLRHGTDWIRACELIHSNPDLKQLFSSQQCLGDNDKHRWLNNWITFDLCFHSFEQIIEGIKLSLQSYNNQDEVKRNEKEPIQHIYIATDFNNESLWLDLNQTLTKHFSSLTLITPSLTLNTMNGTFSEHNKQAHFLIDLYLLSHSNVFIGNCISSFSAFVTRYRLYRFNFFHTTHFFAFHRPNSVHLRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB93</accession>
    <name>A0A922IB93_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB93"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="106" mass="12285" checksum="396E2DC9BD3F2EAD" modified="2023-02-22" version="1">MDRNNIFNLTRSFGCHSKQSFNGRPFGVQVANLNPFTINEISTHILRNHVLWKIYTTLHNHQANDSIQIHHLDPIFLVLNVLIQHLTIQEYFLNETNDYGSGNGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBW1</accession>
    <name>A0A922IBW1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBW1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1113" mass="123194" checksum="3A446CE1A7919911" modified="2023-02-22" version="1">MKPLNNFVNFIVLIRLIIMVLIILPLSPYYYCLNDDKSALLLTNPPPYKPYYRFPDQCPDLKKTEIEITKETLSEEYYKCQSNHIERWRITADHYYTESEQFCCFIWTVLSCEQPLLAVCNRTYSQLNDEETKRLFRKSCDQYTTCDDGNKSGTDWTLILTIGGIVVTGLSLLGTATYAIKRFRSWRKYRNMDKEALDKLKNVNSFLNERIETEYSKLTTEADARESVANLDGSGGGRWQFIKNLDKLGVGKFFRNMKLKKQARTNVYKDLDERPKEFWQSFFDANNINEIPIEDDRKSQLSTGQLSDSGVEAEPGRLSKFFQSFNFWKKTPDLTGLKDVASETGQGLNETLENLAETTADGLKSAADIALPVLTEGTKATAQTTWWMTKFLAKVGFETGKLGLNVTRAVVSPLSEVATDVLSDTVQALDAVAPQIGEAANIAAEGTLEGIKKTTPLVATLAGSAVSGAAKSTWWVARLLGKGSYEAGKSVIYGLSKGVAIGAKSAYQHMTSNGSVNNGGGVNNNVINANNNNNRPNLPSNFNYPSRAPPPPPAPSPQRSNEIRQIVPVPVPGGGSDPNRTLRYLPHGGGGGGIRPNQCPDLKSSNVEISKETLSEEYYKCQSNHIERWRITADHYYTESEQFCCFIWTVLSCEQPLLAVCNRTYSRLNDEETKRLFQKSCDQYTTTCVVETKSGTDWTLILTIGGIVVMGLGLLGTATYGIKRFKSWRKYRNMDKEALAKLKLMKSFLNEQVETEYSKLVTEADARENVARLDDGGKWQFIENLDKLGVGKFFRNTKLKKQAKTNVYKDLEMFSQSLFDAAKTSDIQINDLSQVGLKSDIVDKATILSTPKAVSSQIDPSKAVSSQLDQIKVVSSKIDPSNAVSSQLDPSKADLSNVASSQIDPSKAVSSQIDPSKAVSSQTDSSIADLSNVASSQIHPEKIDSSSVAQPPLKSDMLSETIRDEASQGVTDTIKSSFAGLRENLPDTSEVVGSITKTLAYAGETTLSAARNAIEKTSPIASTAASAATNATSWIQGAAHKLRSGFKSIFNHMTTTNRPKNDQQMNESNIMENIVDPLKLGEETTNIDKHIKITTKQMSDFELMLMDDYHFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC21</accession>
    <name>A0A922IC21_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC21"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="159" mass="17856" checksum="69A43B1EBE42E235" modified="2023-02-22" version="1">MRMTSIINNTDITITTCTKTLMMIIMNNAKMLNNTMVKYTKNDSSSKSSPSSLSSSSSSLLSIDEKTAILYGVDYSKRKSLKKIIQKSLIIHHHHHYRRGRDSNNNCTSISSSSSSSRPTMAMKTLILSLIFVIFINMVNTISALIYDGKCLKNEYDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC59</accession>
    <name>A0A922IC59_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC59"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="288" mass="33685" checksum="EA2D5EFB4C334485" modified="2023-02-22" version="1">MDNYNNDDNVVKMNPITIESSSMKYLCKYKIKRKKMMQQKTFANQKSSLILVKRQKQTPSTKSNSMSLTLNKRDIQQNYSSKFCVKRRKKSFKPDDQSNDNCSSRYKSLAIFKRRRKQIKNSENEKNEIQSLKRRESKLLFTSKTCEQPYNDDDEKTLVGKNNFFKIETSSSSDSDYSSSSFIKSDRIGKSNNSMEKASSQILDNNKFPNENDKKMISVDTDKNQKNLEEQKQQKHIDEKEKLLPQLESVIQQQQNITENQQHNDDEKMAKNKLHASPTPPPPQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC62</accession>
    <name>A0A922IC62_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_002727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC62"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14699">
        <property type="entry name" value="bZIP_Fos_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="245"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9528811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="328" mass="37366" checksum="8DD86209B9964FA8" modified="2023-02-22" version="1">MSDFFEIQQQQQQQYMMDMNPIDEDINNVPITSGDLLSNLGQDYYMNNSFSHQLDMAQFSNINCPTANNGNNQVDLGAISAQPVVINNTDYYYNDINWNYSPISEMISTSPQSTASNFSTPSIVSDYANQTQLPQYYPFNYMVSDVSSQNQSNVTKDWDHYNNGNIDLSFFNQDVVPLPIPSASMSDAQSTLVNPESMIQQQQIKPTTVNKPVNPKSNSNQSSDDLARKLELKRERNRVAARKCRNKKLQLIEEYKKTNAKLQKDIEESEALLRKINARKFELRAALLNALNSYPLQSFNTFDSIAECNEQSIHNSISINNNIIELNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC79</accession>
    <name>A0A922IC79_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_000744</name>
        <name evidence="7" type="ORF">HUG17_8493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7641024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC79"/>
    <dbReference type="OrthoDB" id="6507574at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="457"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7641024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9526679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="554" mass="63143" checksum="5F5CEF18928E2B64" modified="2023-02-22" version="1">MLEEEKFLVKSPNESTRLPMISVGQFITEQLLKQQQQQTIAVIDATDIHGNGIQITCGELDRKIRQQAARFLAIGLEKNDLVVMFADNSLDYLISMFALMYLGITFSPLTPASGCFEFIGQIEDSQATTLWIDGKRLPIVEKAIRERTSIRELLRFLFICDDVDESILSEMKQYPIQIIANMRELDNEILERVPYFDTSPNDYLMIIYTSGSTGLPKGAIHTQTSVLASTFIFRPQQMGIRYLMWYPFGHVSGIFATLKTLCWGQTLILEQCCQLPRMLLDVERYQATQMPIAPSQAIDLLNHDHHRQFNLQSLKVISFAGAKIPADTLEQIKSKYQVKISELYGSTEMMGSVVQPAHQVIPPGSVGVPQSNNEMKIIDIETKENLPAFQQGEICFRGPARFLGYLRNLRATDEVIDSNGWYHTGDIGYYDDNGHLYVVDRIKALIKFRYWSISPAEIELFLQQHPAIDNVCVVGVKHLTEGHIIRAYVQMKKGNQISEQELLQYTRENLGFQKQLRGGVRFVDQIRRTAIGKVDRQYYNRLNEGQILADPVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICH4</accession>
    <name>A0A922ICH4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RABL3</name>
        <name evidence="4" type="ORF">DERF_000875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICH4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9526814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="257" mass="28886" checksum="50D1649FF8F95815" modified="2023-02-22" version="1">MATINEKIKILVLGDSGVGKSSLVHLICHSETLARTRWTIGCAIDVKLYRYKEGSPQEKTCFIEFWDVGGSRSHSIARKIFFNSFHGIILVQDLTNRKSESNLKNWLGQALVGTYNNNNDKERFYSNSLSQALFPVSDNDDFEHDSESFVGLNIPILIVATKQDLVAANVSTKTNLVDLLHCDSIQLNCRNPKSLSPGTTNAVKLSRFLDHVCDKRLQSCSSVNLSNDKNVYHRQSSSSSSSYYYYPNNPNNNNKMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICV2</accession>
    <name>A0A922ICV2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICV2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7735" checksum="A487E2B1681CEAA1" modified="2023-02-22" version="1">MISWNDRYLRDRFGTNIKSYVQTCMMHTLTGHGQFGAYLSKYDTSNDKNAAVDSDFSQSNTLSTIVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ID98</accession>
    <name>A0A922ID98_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ID98"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="118" mass="12761" checksum="CD1143C7E407AEC4" modified="2023-02-22" version="1">MLPLLISVFGFASAQYSGLAGYGNRGSGYNQQSYGQHGYVQNGYGQQHGHGQHGYVQHGYGQQHGHGRHGYVQHGYGQQPTYGKQHGFGQQSGYGNQNLGQNLVGQILGSLGQRQLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ID99</accession>
    <name>A0A922ID99_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="3 10">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GYS2</name>
        <name evidence="12" type="ORF">DERF_001925</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="3 10"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ID99"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000028">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="657"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="657"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9527940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="710" mass="81660" checksum="CE55A428C20434DC" modified="2023-02-22" version="1">MMTSNSLMKSTETASNRSNRRFYRVDSIPTGDHGLTAEHENKWCFEVAWEVVNKVGGIHTVIRTKAQTSVEELGNRYFMMGPYMEQMVRTEVEIEEEPVERCFRETIKIFRDHGIKVVFGHWLIDGYPAVILFDIESASFKLNEWKHNFYEVTHIGIPHQDRESNDALILGYCVTWFLEEIYKRIQELYGTPLMVAQFHEWQAGVGLILCRTRHLDIATVFTTHATLLGRYLCAGNVDFYNNLDKFHLDREAGNRQIYHRYCMERAASHSAHVFTTVSDITAMESEHLLKRKPCLITPNGLNVKKFSAIHEFQNLHALAKEKIHKFVRGHFYGHYDFDLDKTLYFFIAGRYEFSNKGADLFIESLARLNHYLKSSQSDVTVIAFLIFPGKTNNFNVESLRGQAIAKQLQETVDEVQENIGKRLFDILLQGRLPGPSDLMKQEDIVELKRCIYAAHRSTLPPVITHNMQDDSSDLVLQHIRRTQLFNNRSDRVKIIFHPEFLSSTSPLFPISYDQFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSITTNLSGFGCFIQEHVADPISYGIYIVDRLHKNPEESVQQLAQYMFDFSCLTRRQRIIQRNRTERLSDLLDWRNLGIYYRKARQLALHRMHPEIMTEDGTIASFNFPKPISAPATPASSRAPSPVSSDDDDDSVHSDVERDILTNNDDNGSVEAILNKAIASTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE62</accession>
    <name>A0A922IE62_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphodeoxyriboaldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_003414</name>
        <name evidence="10" type="ORF">HUG17_5369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE62"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF3">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="9">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7642324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9529535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="322" mass="35906" checksum="362EB176261D19F4" modified="2023-02-22" version="1">MAHFDTTLLKTNIVSSEVKQIAQILKSNSLSIYNDNDDAKLRDLLLVLNCIDLTTLAGDDTYSNVSRLCYRAIHPLSNKIVEKLSNHDDYHHRNNITTGAVCVYPLRVGDCRQYLDRIDSNLSIASVVAGFPSGQSPITVTLADITFAIQSGANEIDIVINRSLVLAGKWQELFNEIKIIAQHCHDQNVHLKVILSCGELGNLQNIYKASMCAMMAGADFIKTSTGKESINATLTYGLIMIRAITDFYIARKIRVGLKPAGGIKNASDALCWINLVRFYLGPEWLNNKLFRIGASSLLNNIEFEIFKLLFHRKPIENELSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE86</accession>
    <name>A0A922IE86_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE86"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="172" mass="20065" checksum="B5E09DD0FE36B6F8" modified="2023-02-22" version="1">MVGFNQESQPSHPFKFYTTQCKQQLIDIVETAFRIQRHVKTDLETSISNHRQTPILRPSQSSDRTWLSILGTKYTKACGRKNKGTISEKIHFHSRWLQALIESTEAQTSWFHLFAFQWFHVLFNSLFKVLCNFPSRYLFAIGLAVIFSLGWSLPPTLSCTLKQPDSRMYRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEF7</accession>
    <name>A0A922IEF7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEF7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="7702" checksum="8073960A12FCAC7E" modified="2023-02-22" version="1">MITLSLHIACVSFTMIRFSTNTNSYSLANSSAQSSSSLHLDSCPITQNVDSSSLFKSSNAINHNFNDDDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEL0</accession>
    <name>A0A922IEL0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_003922</name>
        <name evidence="2" type="ORF">HUG17_5777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEL0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276978" evidence="1">
        <location>
            <begin position="21"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7642730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9530086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="170" mass="17144" checksum="4C9C13A9A8311C96" modified="2023-02-22" version="1">MLRFPLFITISSLAIVLVHGGQSKGGDTIIIGGGGGGGGDDHETKMIPIPIMMPQPKTYHHSYTKIIPIHIPAHQPHVFNVYGGHGGYGGHVDHQNYDYYGGGYGGGGYGGGGHYGGGYGGGGHDSGYSGGYGGGSGGMGGHYSSSGYGSYSSHMNHGGGDDGYGGGSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEV7</accession>
    <name>A0A922IEV7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEV7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9530179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="103" mass="11780" checksum="95E645C86A5EB719" modified="2023-02-22" version="1">MNTVVCWFVHGDFKLLILLVFVDYLVDFSVYISLIGFIDSSQIMLNTVAFLLICCLYGGYVLSCQYLFNSMGRSNGRQNKYNVWLDDNVDGDGNDNKNDKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF58</accession>
    <name>A0A922IF58_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Splicing factor 3B subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SF3B3</name>
        <name evidence="12" type="ORF">DERF_002885</name>
        <name evidence="11" type="ORF">HUG17_4956</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF58"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000002">
        <property type="entry name" value="Splicing factor 3B subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000027">
        <property type="entry name" value="Splicing factor 3B subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000031">
        <property type="entry name" value="Splicing factor 3b subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="9">
        <location>
            <begin position="14"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="10">
        <location>
            <begin position="445"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="8">
        <location>
            <begin position="859"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7641911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9528975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1212" mass="136235" checksum="ECEFA9EA7BD6EAF5" modified="2023-02-22" version="1">MHLYNLTLQRATHISLAVHGNFAGTKQQEIALAKGRILELVRPDPSTGKVYSLLSIDIFGVIRSMIAFRLTGGSKDYLLVGSDSGRIVILEYIPAKNCFDKVHQETFGKSGCRRIVPGQYLAIDPKGRAVMISAVEKQKLVYILNRDATARLTISSPLEAHKSNTFVYHTVGVDVGFENPMFACLEMDYEDVDIDHTGETAQQTQQQLTFYELDLGLNHVVRKYSENLEEHGNFLISVPGGTDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRYDLDDPDRGMIFVCSASHKTKSMFFFLVQSEQGDIFKITLEVDDDIVTEVKIKYFDTVPVATSLCVLRTGFLFVASEFGNHYLYQIVHLGDNDNEPEFSSSMPLNEGETFYFTPRSLKNLVLVDETESLSPIMHCQIADVANEETPQLLMACGRGPRSTFRLLRHGLEVSEMAVSELPANPNAVWTVKKRSEDKYDAYIIVSFVNATLVLSIGETVEEITDSGFLGSTQTINCAQIGEDALVQVYPDGIRHIRADKRVNEWRAPGRKQIVRCAINSRQVVIALGGGEIVYFEMDLGGQLNEYTERKDMNSEVICMALGDVPTGEQRCRFLAIGLADNTVRIISLDPLECLTPLSLQGLPARPESLSIVQMGLMKSDEKSKGKLYLNVGLQNGVHLRTVLDENNGTLSDPQTRYLGSRPIKLFQVCMQGKESLLALSSRTWLCYYYQNRFHLTPLSYEPLEYASGFSSEQCPEGIVAISHNTLRILALENLGNVFNQHLVELEYTPRKFAIHPETYYVVMIETDHNALTPASKTVRKQQLAQEMIDSAPADEKQHVSEMAAAFLKENLPENVFGAPKPGPDTWASLIRVFNPVNGKTLHKFSLEQNEAAFSMTLCRFTNDPEGYYILVGVASRLRLLDRQHSGCEIHTYKFETDLEHLTLVHKTPVEDVPRAMAQFQGKVVIGVGKLLRIYDLGKKKLLKKCENKTIQNFIVTINTMGNRIYVSDVQESYYFVRYKRSENQLIVFADDVFPRWVTCTCILDYDTIVCADKFGNVSIIRLPADVNDEIDDDPTGLKSLWDRGWLGGASQKAETICNFHIGDLVLSLNKATLIPGFSEALVYTTISGAVGVLVPFTSHEQLDFFQHLEMYMRSENAPLCGRDHLAYRSFYFPVKNIIDGDLCEQFNSMDFSKQKSIAEDLDFSPAEVSKKLEDMRTQYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF86</accession>
    <name>A0A922IF86_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF86"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="125" mass="15230" checksum="FB5209F274B5D747" modified="2023-02-22" version="1">MFDVWLTRKQFFIEKLFIARTVERFCHSNQLIGNEWWIDRYMNKSLSYENLIEMFLCYFISVLINNAIHLSILFYLIFFSDADHRGINFLFSNEWLNLAMFAILFACDLYHYPPSCKKKSMKDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGE4</accession>
    <name>A0A922IGE4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional adapter 2-beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TADA2B</name>
        <name evidence="6" type="ORF">DERF_003108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGE4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF63">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="511"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9529214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="645" mass="75204" checksum="2781FA79F6479FE9" modified="2023-02-22" version="1">MDNEDICKHHCTSCMNQARDVLFSCVECEDFSLCLQCYVYGTEIGPHKRDHEVKMIDLGTFPIFKTNKRDIDEPMGTDYSESAIDNEIENIKKDDQEFEKFLNEELGQEFTENHVIKETQTQLPARMDTGREEYEWRAMDEKALFEALTRVGYGNWKDVANYINTTLSTNISPSEVERHYNIHYIDGLIGRLCWTWMFTDSVVRQLSRFPFTIRGHHDKLQPNKDNCSDLFRDIPQAELDSLGYLPKRDDFEREFDNEAETLISNLTLGAESEDDIEKKFKLAQIDIYQRRLISRFRKKLIIRVNELIKLFLEVHKSEFFKDSLQARRDSNSKIFKDFQEKYPMFMPFVRYLRKQDLNSLFQDVAIEQVLKILLKKVILFSILSTNNLDNLKSEDKIKMIQVFNKAINEKVEQSSDERKVETNSTDNSSSTKLSTKPTKTDSIDVEDLDDMDETDIMDLIFADENQVDRDCLNQIINHESIQSLSRLTADFIRKSGDEEFMKEALKFLNQQQSSHWKNETESEELPISSSPKKKMKPDPDNLTTEADESESIAHLLSDMETKLCTELKIEASMFIQMKNVLIKQHKKYPKAARHRLNLENIITKHYYGREHLETLRRIHTHLITNGELSSSATTSGGSNLTPSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGU3</accession>
    <name>A0A922IGU3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_002947</name>
        <name evidence="7" type="ORF">HUG17_4991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGU3"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="48"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="397"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7641946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9529038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="568" mass="65679" checksum="5265F4488B9719CE" modified="2023-02-22" version="1">MLPYFSTDDGFSSSLNPVPPIVNNHIDKINIPESFFITDFYKNKTIFITGSTGFIGKVLLEKILRQFPSVGKIYVLIRSKQSESCHERLAKMLSTSLLFKSHQDNIDLIKAIDGDITAKDLGLSEGDRQRLIEEVDVVFHSAASIQFTGELGKFIKQNIQGTDSVMRLCQDMKHVQSIVHVSTAYGNCHMNEVKEKIYPVVNDQDVEVYIKQLMEKYADYDLCEGHSALQNRPNPYTLSKSIAEWLINEKYQSTLPIIICRPSIVICSLKEPFPGWCDTINGVSGSFILLGLGIVQKFIVDKTKTPDLIPVDMVANSLIVCGAYRASSHYSPERNVVHITTSTVNPVSWSKLFDLGIKYENRIPSMKQVRPISRDYSNNYATLFDKICYKFHQIIDHLLFAMIFDLICMIMGHKPFMIKIMQRFHNSMYEMKFFSLRQWNFEHKNLPYIYKLVNKKERPLFNCDVTTIDWEDHAGNMCYGIRKYLLNDPDSNYEQARQRRYRIYLGFRLFTVFKYFFFYLISKKYLLETVLGVTFYGLSLSIIDLATYSYLIACVFTAFKTFNKPKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IH22</accession>
    <name>A0A922IH22_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PUS1_2</name>
        <name evidence="6" type="ORF">DERF_003878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IH22"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="5">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9530039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="150" mass="17652" checksum="2E9261A947C4EE7F" modified="2023-02-22" version="1">MEFIVARIKGQSFMLHQIRKMIGLAISIMRGFVDQDVIKRSFSIDRIDIPMAPGLGLMLEEVHYEQYNKKYGGDGIHEPIVWDEFNDEIYDFKNKFIYPEIVATELNESSMLQWLNTLHIHTFDIRNHDERQKQRIRLNDLVNLGCIIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IH42</accession>
    <name>A0A922IH42_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IH42"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="81" mass="8918" checksum="EA5E0A2DCE5EDAB4" modified="2023-02-22" version="1">MSITDYVFFAFIHSLYSLKTDSNEKLRFCSSNPSFCDAHCNSWLVLVEFHVVIVVDCDSGDDGGRGGCGNDSGPEFITTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IHE5</accession>
    <name>A0A922IHE5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Box C/D snoRNA protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZNHIT6</name>
        <name evidence="9" type="ORF">DERF_003882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IHE5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="8">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9530043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="318" mass="37400" checksum="9864C039E345D860" modified="2023-02-22" version="1">MENSSKFFGLFGSVASDNNESDVIAEHDVAESSCNIDQPNHGLLVNRFVEEVTAKQERKNVKNCSICEINIHKYVCPRCGTKTCSMKCSTKHKQSTGCSGIRDQISFVPLKHYSEIHLNSDFRFLEKGIEYMQNSNRILDNNPKRQLSTWAIRFAQECQKRRIQYEKMPIAFKRARSNRSIYLYKEQTIYWDIDFTFPNCQSKNEASVCQLCFKCNRISENRLLADIVQEIIDQPNSIVNNNNDDDDDDQCIDRIDEFDFTPYRNQEYQILLKHKSGRHYYRLQREWTLKRNLEDKSIVEYPILVIVLAEFVHNYNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IHJ1</accession>
    <name>A0A922IHJ1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RCC1 and BTB domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RCBTB2_1</name>
        <name evidence="4" type="ORF">DERF_004141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IHJ1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051709">
        <property type="entry name" value="Ub-ligase/GTPase-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622:SF58">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="173"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="229"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="349"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9530328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="511" mass="59073" checksum="7B4AF37282C76C18" modified="2023-02-22" version="1">MERSPTENIDIDLFKDDLENIDQGFLQSIISIFSFILNGKNEFLLMTKEATYAYGKEICSWLSLEHNMSKPQRISCLDDMKIVQADFGWNFVAILTDDGRVYLASEHSNWNWKTNNTFRLINTGNDRFKMIACGESHLLLLRQDGHVFAMGDNSYGQITVCGRFHSFSITNNGEIYSWGLNEFGQLGLGDEKNRNTPCLIPFPNDDLIDIRIKDIVAGMYHSLFLFENGQLWGCGSNKYGQLGLGDDIKRSKLTKIPIENVQQIACSKFDCFSLAYDGSSYYAWGRNSSWSSPKKLDYHPTSFASASTMILSSPLTFGLTSTIYEFGSHDSISYQCKSIIQLFDNQDSYDVEFLIDKKRIKASKCYLKSVSEYYRRMFSGNWTENDQVTIDDYSYETYYAYLRMLHTGKIYITRQNITELVDLANCYGDEKLMKYCQTFIRNDLNEHTMSTYSSLIEKYEMKKLYDKLAHLTIEQVLPNVTHSILQNNEKCIKFLKSIYDQQLLFQTDMNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KX78</accession>
    <name>A0A922KX78_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Epidermal cell surface receptor-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_013899</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has antibacterial activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050941">
        <property type="entry name" value="CCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348">
        <property type="entry name" value="CONNECTIVE TISSUE GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11348:SF34">
        <property type="entry name" value="EPIDERMAL CELL SURFACE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037414005" description="Epidermal cell surface receptor-like" evidence="5">
        <location>
            <begin position="23"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1653"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="273"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="9">
        <location>
            <begin position="466"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="546"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="7">
        <location>
            <begin position="1115"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9497969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1763" mass="199082" checksum="EC268D575DF9A8DB" modified="2023-02-22" version="1">MAIKILIILPIILLQENSIIFGSEIPITTNVDSTATTTTTAVVDLHENIFSYSPSSSTSSAPSSISPVNHCHRCINGGHLLSSLIIQEQKSDCISGHYFTSLKNNNDRCECDFICAKKSGQTCYNPSSLNRNMNNNYNGGAGSSSFSHCDPYLKLFCNQTSKLCEGSLSLIIDQIQNDSIQIEWKSSSSSSSFSNQLKLNRNPIINEIHITRYVPQPLKFQFEKIDSKVTEISDGHFRTKIFGLKPNTIYLVKVISNHREELSIITTRANIVPETLPKVLVTYRNASSITIVFDDFKPDTDSGYAIHYRPNSGFMQQHNQWLIIKSNGTPFFTLTGLKPQSHYMIQVFTWSELDHKQTLSSEIIETSTTKGCLFRNRSFELNETILNDCEQTCECVDGSVNCRKRCVAPYLSVNEAKKINLKCTFVDDDDNDKCCLQCINSNGDHHQISSSPSSFLLERETQSTQFIGKPGICPTNPSIIHGADNHTTCMNECTHDYHCTGVNKCCKNYCGLLSCQIPVKLYNHNQQHQHSATISAKVMKNDGDDDDDDCPLKCDPNSICRYIEKESTYRCICRDDYINMKVDKMNGCHRYDDYVSNGNDGDRKHLCHFHNNNKTYQIGQTFEYDCHICQCSEALEIECKRKCFDYQSINDDQIGANCHLVEDLYDPICCKKKICHNQQNHQNETTNIPCHHSNQTYKVNETFNIGCELKCLCQMNGQIECQPRCFDDDDHHGHYHEMYCHLRPDPDDPECCKISICDYNNSTIDQHKFLVEMAESINSTSIKFPTTTTTDELKYQNEIITDKMMTIVTNDSKEIVLTHLKPETDYSIYFHFGNDTSNTVIVRTFPPGIDHTFKGCFHGSDIIQVGEIFYDGDCEFKCICKEGGIRDCIERCPLFVDMIGAENCQMIQSPDDSCCMIPICDVHQLIGQSNDSNGGCLFEDGKYYRIGDQWNYGHGCMEKTCSCIMNKNNFTEIKCKNHCPEILPSVLKPNDDCPSPKLIQTNDPCACPYVVCANNINPLDMPDLKTLSLTKNMAVANKNYCEFKGNKIGIGEEFYDSCRAVCVCSMNATFDCHPIQCNHNNFGPHTTKCLEWEIDPLFVPRPPNCCPEPKCKNDGSCSYAGIRFPNYQIIPQELLPCHKRCMCDNGNVRCKDICPDIADEPPLGLPCPSSLAFRGHLPGDDCCIHWQCREQYNRDKIYGKCSYNDKIYKLGEYWNDDETEIHRRCQCKITNGILHVVCDPGLCQPITERFLEPTAECKTPTVVTPKDAIMCPYVICNNTGTYGDDLDQMDIVAINATSARIRFTIPSIYVGLLGHAEVHYTTDINIPRNKWNIQKFARPKRLFDIPNIEYHLGNLQPNTNYFLQIEIIIESLKTGPISEIYKIYLPPLPVKTTTTTTTTTSTLPPVIMLDMNITAAIIDHNAIRISWRPFTIQEKKFIDGLQVRYRKSDNRNNNNNDNDDDDDNVWFSSQTLHRDTTFYILNKLESSTAYLIDLHFKSIDQISANIISSKPLLIETPPTALDDYHFDFHIFPDDVTIGSDGNGDNAGGRINIGLRNLPKPINKFVNVARIHYQNVKTMESYYNYVNVDDDEIGKISFSSLLPNTRYKLWIDLYLTNGQVVTSNTIDLITNFDANPFKDKNSALSLANNTTSRYMFGLTILSIFMFTAGTIFFVITCICLRRHSTAAITRGGGDGNVCITEAAYDNPTYKTFEMKPDTKSIINHEDHHSLSAAVAAAAAAAATTTMTTINTAKTTNGCSVVVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KXA4</accession>
    <name>A0A922KXA4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Interferon regulatory factor 2-binding protein zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">IRF2BP2</name>
        <name evidence="7" type="ORF">DERF_013941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IRF2BP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KXA4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1580:FF:000001">
        <property type="entry name" value="interferon regulatory factor 2-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1580">
        <property type="entry name" value="Interferon regulatory factor 2-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044882">
        <property type="entry name" value="I2BP1/2_C3HC4-RING_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022750">
        <property type="entry name" value="IRF-2BP1_2-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057414">
        <property type="entry name" value="Zf-C3HC4_IRF-2BP1_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10816:SF19">
        <property type="entry name" value="PROTEIN INTERACTING WITH TTK69 AND SIN3A, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11261">
        <property type="entry name" value="IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25454">
        <property type="entry name" value="zf-C3HC4_IRF-2BP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like zinc finger" evidence="5">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon regulatory factor 2-binding protein 1/2-like C3HC4 zinc finger" evidence="6">
        <location>
            <begin position="566"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="452"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="653"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="746"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="525"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="658"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9498014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="770" mass="79759" checksum="95D2C28930BE1204" modified="2023-02-22" version="1">MSSSSNGHRISLTGTNNNNTIVASSIALTPSSSIHGGGHSATQSSSSSSSIINLTGQHPSTATVSATGTLLQHHHNNTIVGMATTTQRQNCYLCDSPRMPWALLHDFSEIVCRGCVNYEGADRIELIIDNARQMKRATGHLIAQQHHHHQQQQQQQQHHQTAAINHHHQHAIAAAAAAAAAASVPFVIPQTGNTHGVVTPTNLTTNDHHQQQQVVSANLLRSSAAAAAAAAASQQQSQQTFKLNGSLTGYGTTAAAIEHRSQSVGSSGLSSYENSGRGSSPRTYVTNPSLTLASTTLVGGGVSLSSRNSSGPSQSSSTTTSGKRTIHIADDINDVDVVVSNTHRTHLVLDEMNAAVAAAAVLSAGNRPPLTRGESLPAVMAAPGIALANDPTLRKLSRADQLHHSSHPSMSRVMSFDSTVSAKNLSASGIGMTKPFYSAAVAAAAAAAASATSPPLIGNQNSINTSSSSSSSTSLLPIKKSRTSNQSLVDQSVNSQNQLTVPSSTANSMVNSHHQQQQQHHHHQQQQQQLSNHHSPPSSATATPPAAPSNASSSSTQATSVQSPPLKCTLCQERLEDTHFVQCPSVSTHKFCFPCSRASIKQQQQANAIVSGNIGGVGGGNGEVYCPSGEKCPLMGSSVPWAFMQGEISTILGEDNTHNSSQSINSNNNNNNVASSTGGNQSSTTTSSSSSSSTSSTTTTANNNTNSLPPPPGLTVATSISTTNALTVDHHSIATNGLATAAAAANGQPLTTTTPTTTVPFKVKKERSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0N9</accession>
    <name>A0A922L0N9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Somatostatin receptor type 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SSTR5_1</name>
        <name evidence="13" type="ORF">DERF_011626</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0N9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="64"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9506918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="433" mass="48711" checksum="E839086F2281534A" modified="2023-02-22" version="1">MEIEHFNMTHLAIQANETLKELLEFEDSLDSFVGNMTGTAESLYTALEFSKIFHYIAAIFGVIGNLLVIIIYLKNHRIRTVTNTYILNVAISDLLYVITVPVFLISIWSNSWPFGEFVCKLLLSKGAIHRFASSLFLLVLVIDTYLSILKPTLSHICYKRPINSRMICILTWIICIISVSPVFYHASTFSVPNSEINHCDLFWTGSSREAYIWFTIISAFIIPTIIKILLAVPLIYTLAGENSSDTIASEGQYQVFAERNKRSAHLILTVIVFHILCWLPLWISLISVNLLPMNEMPDNSAILFHMISGCLGMANTVLNPFIYFKLSPEFRNGFAELKESILYRSKASIFANGGNGNGGGGVLENSTNSNDGIIGHVNNGVNGTTSKSNDSFVNNFFPTNVFQRYDEERNQQQQQQRQQQQQQQCTGNNQMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0Z1</accession>
    <name>A0A922L0Z1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MDH1</name>
        <name evidence="11" type="ORF">DERF_010734</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="8"/>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0Z1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000010">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000002">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003916">
        <property type="entry name" value="PRK05442.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="162"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9505972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="329" mass="35539" checksum="0582258B47020766" modified="2023-02-22" version="1">MSSSPAAAAVRVLITGAAGQIGYSLIPIVARGDVFGREQSIILHLLDIPPMKTVLDGVVMEINDCAFPLVQSVVATTDEAEAFKDIDAAFLVGSMPRREGMERKDLLAANVKIFASQGRALANHSKADVRVLVVGNPANTNALIAAKFAAPKIPSRNITAMTRLDQNRAQHQLAARNGCPVSRIERVIIWGNHSSTQFPDISNALMDGQPIKFDGHDEKFIQTIQKRGAAVISARKLSSAMSAAKAAADHMHDWWNGTKTWVSMGVISDGNPYGIADGIIFSFPVECQGREWKIVPNLSWDDVAKSRIQTTADELLAEKQDALSETENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1X3</accession>
    <name>A0A922L1X3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_011725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1X3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000096">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 18 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="777"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="509"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="814"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="914"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="828"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="936"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="954"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9507022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="971" mass="109226" checksum="B92F3F22B5E581F4" modified="2023-02-22" version="1">MTEIKTNVNHLTIVSPSTTVSTAVADMVGAVINNVAESSMNDINNDDDGDGVIGQLELDHQSQLLQNYSFNSEKQTNEMESDDDDDDEMMVDDFEYPSDFDPNDYEPIEFSKEHKRKLLSLLNMIIPDLNPLNSFNLSTNHHKKSSKSKLSSSSSSSSLLNDSAQNVLARLTCLIQLFNDFFRPQEIWPLLGRLPLSLRMDKSSKRLKFIEELDSKKIRQLNNYFRCWLYLFYTCDEIIESIDIMEQSSSTPLEMFTMMILNVFNHLRDSLPQIRQIFIDHWFPLESFEKRLECFFRYDKIHQIIIHRLAHERLIHTLMNEKYLLVKKQLELKTKENDQLQLQLSRLQSTNSKNTLIQNNKSQINEMQTAIQSTTAPQTKIKPLSFSFSSMYNNNQSGKSLLPQQQSSSLQPKSQLKSILLAQPRSPVPSIITSDSCSNSAYSSSGSTSPTQSILNSTNSDISNRIKDSKPTSLDLAKAVANKIHQTRCTTKAKAESASAAAAAAALSNNNNKTNAPDPEYSIFGRRGRPRKFSSLNDSTDECKNQNKKARISAQTKVDHQQPNDQLMQSIRSRSRFKMKNSLLKIDSAETVNNKNSPKLPLSLNAISQQQTGPLKPIVKMNSTIGSKSLLDTTSSNNNSKNNNNDNSIKLYEKSSKSLIIKPLQVKTESPTMSSLTTFEEKFNIKIHGSNQPSSSSSSSSLPEINLALFYFVDSSTNRLICRICSENLNDMDKFLKHLDEHVTNNDVFQCEICAKIFTTKYKLTRHLPIHSGEKPFICQKCNRCYSRRDKLNEHIKAVHSEKPFVKNRIIPTVSSNEQDTKPQSLKTYGTTTNGTTTTTTTNHIDDDDKSSNNGNDVLSSNCTTTLSNGNGNGNTTCNLNNSSNDKCMATNNDSSKQSSSALKIEEILINDDSSNLDNSEFEPIGDNCNNANDYGDVDDDDDDDDDDDDDDQKQDQDLDIKSKIEIAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2I8</accession>
    <name>A0A922L2I8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_010828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037986616" evidence="3">
        <location>
            <begin position="25"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1320"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1405"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9506081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1428" mass="166625" checksum="073E383E7A6086A8" modified="2023-02-22" version="1">MFYSLFMMFWILFLLLFNNQESSSLELLPNDAQRTINCGLHYLPNTIGISIIQQHLIQFVEITNEQKIDLLIVMYDHLLSIDQNFPFVNLVNGYSLSLSKLIENQTVAEQFNEQLMNWRPDLSMTQISEQQKHRPRINIAWSKPVIGARGANPQFRSSLYSTKTYDYKHFQNGIFRNQSVNNPITSFYMDNSHTKYLFLVSTIESTLSFEYHVDNDELAIYLWYSFHKQLVGYLKFDFRAMTVMLFRKQISSGLTSEMMEDYDFNYGFELYERNIENNNNYWRIFIVSNQKKLILSFNANVLRQFTKKFPFIFLKLEEFFYCQHIDAKIRQLDKPFKNEIIAQTSLPLSSSSESLAPSPEFSAPSSESFDLSPSSVFASSPESESFAPSSSSSPTPTPTPSPSPSPSSDLVSSMTSSEPLLELKMKMLEQYRIPLFIGGMVIIAILLFTIVGATICIRTRRLLPGMTMNNDDTDYMFMDISNGGGYNDGGTPITLFKRSPKTIPVLKNTDLSTNYNHHHQSLWSLNLIDGYLFIFKEFTTNRLERMLMEQFKWKEQKEIEQKPEIRIIMGYTKMTGYIFDSYITYDRIEYRFGYYETIGYYFSLNKDALSVDNRNSWYENQDKLFNNQWQYGFTMDSVVIEKNESEKILFLVSSDKILAVNELLLFDLKGEKMYNIHLMKFNDYFHCIWSKIMDINHAMNRTNRMGEYLKIIIFILTLIILLAVMISILIALYNYRRSLDQTTTTTIDYYPNKYRLSETISLKTIDTIDTFVDRKIKTMYTTSLLALLISVRLNLGNAQDEQQQQQQQPKMIKCGCDYLNNTIGISITENNQIYQMLYTNQTLQVIKYEQQINGKRISTVNNKPNSYRMNLIDGHYYYHLNQLIQSPDVYKKLLDLYFVGNYGNFSDIYKFMIYHNDSNIIVISNDDHLLFISYRMNEDSIRVNKYGNDSLKLLVRLHYMDHNGLDYLYSAQTRSHYWSNEQTNRMKQNIHRSFQPVEYGFIINKGDGPPPPPPPNNAAILNDEKIVFLLSNSRQTILSFNFNAFYTDKMTFPITIQSYQDFFYCESQPPPPPPPTKGNDDDDDCEDDENPYKNDVTTISRTVVEQTTKIVYQEYHLLLYTKTIGLSITGGYLYQFLYINQTIKIIIYDPYKSILIDKKNNNNYQLNLIDGQLMTNGIDDIINDHTNKLIRIMLKYFLVNTYIGQMLWALFRLNIAKLTTKHYGVSGIYDWTKILYIDPENHQKFIVFNGFASRSKQQHNYEFNHHLLNNSVFTFGFVDRISGHSGGGGGDHDVERIFLFSNQNEKILSFSTHILVNKNAIILILGPLMIIILIACYRNWKFCYLHSKLSQRIRRLSQRKSWRMYPIYQYQQNSSSSSSSTSKTKTPPQSFLHSLSLKLRSDLKLKKQPNPAPPPPSSQSITELSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2M8</accession>
    <name>A0A922L2M8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2M8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="87" mass="10081" checksum="3D77917AA5759371" modified="2023-02-22" version="1">MIQANHHHHHDDDRPTPNTNVNEPTKTTSNYEPQQQQQQQTWTKSEIDGHSTISTISSSVVIAMIMWYHHASYHTHYHSSIPTLKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2V5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9498030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <name>A0A922L2Z7_DERFA</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="29"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501033.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="86" mass="10512" checksum="0B01171DE6D0B131" modified="2023-02-22" version="1">MKRRKGHISISKHKNDQQQIATIKKDQDDDEERNIFKMFPTPSNLAFIHSFICSFFKLLSTYNHYYYYYNLDHMNEKNNSFWVPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
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        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L335"/>
    <dbReference type="OrthoDB" id="10621483at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
            <begin position="426"/>
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        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7646252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9516673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="596" mass="68010" checksum="772E5292ADB37AB0" modified="2023-02-22" version="1">MSKKSAPKTLSNEKIESDPNDLAVKNQNDQSFSFVTKRPVRISNASTLILDSPIKSEIPSSLSSFSMPSSSPSFRRGSAFWSSPERFDDDGYHHPLKGIIFKIKSTMKMVQPRTPEFDPPMIVDDQFVTRRIRISEAPTLVLSELSSDSSTSPPPSPIRQSSVVSEPLLSMKYQQKIWTDENQKFHETVEVLPKGDTSTNMKVTDKSAKIPFKQLTVTMNDQQKQDNGIKKFEKIITSTPKKEIVNNDQSYEHIIIEFDETRRREDDVARPPPPLVVASNPSTSDDGSLRYSSYAPGRNINSKTNLDESKSRPLMANESESTKLLPSLVDIDDWNDRQNLHTLSSFETTSHTKMIRTKHLKSGGLSWRYPSYDETGIIDSKTNILDSNKFETKKLPLIEDKKIDKYPQKSSVKIEISKRTPESNESSKSIDSIQISSVSDRPASLVGTRSDRQSQSKTSSIARIQQRRSRTRSKKFRGPLVARLSRPNRQLRRFIHRMFHSIINTHDDGNQPKMMISSDSIEILNSMAKEIIRKYAEYADQLILYSGRQKMDRWVSFSTLNMLLAPISHRTKRSIFNIIGEHGYYHDQSEIKIMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3M9</accession>
    <name>A0A922L3M9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase-like protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">METTL6_3</name>
        <name evidence="6" type="ORF">DERF_007860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:60648"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:143891"/>
            <dbReference type="ChEBI" id="CHEBI:143892"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3M9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF103">
        <property type="entry name" value="RE10370P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9517168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="543" mass="63437" checksum="4A0A1FB5F6997709" modified="2023-02-22" version="1">MYDYSIFRIINHQLSFEIVHSSSSSSFKLLITLIFIIINNQFIIVTKTSPLSLSSSSSSSASASSSSNAIVLSSPRRSSPMNISPQIWLSISSKPYRRLVLNWHHIDRRDLYSSWIALYDVEPTTSNFDYNFIERIFPITTTGKHITAKSYEYFSFESAFFNDKNKRYLNDFLRSGNGSALTKLSSSLWSGCIKYWIAYIQYNRRIVVKKCLRTRPRWMEHSMPFIGHRSILELALPGTHNAASYEISGKMNFPRLDKYIYCQDESVWNQLIYGIRFLDLRLAYDNEQKNERDRVWIAHGMVKVDILLVDVLEQVLAFLLSTHQEIIILDFHRFEDGLQESLPDIDERHSIIERLINDYLGSFLIPVDIGWNRPLRELIAMNKRVYIGYARDHRNRQFFHTNALHVWAGSDDPGILFRHLNDRSCRSPSTPYPVSLMGALTPKFFGLLRDKYDGLRSLAEQINHDLSVNVFDEWWQCMNVLCTDYFLGNNIIEYTIEANLWREKNRQKHLQQQQQQQTTSLPAVPYYQKDVNNNNIMLNLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3Q2</accession>
    <name>A0A922L3Q2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3Q2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="258" mass="29649" checksum="B841FB8D22B41423" modified="2023-02-22" version="1">MSTNNHDKGVFSTIDDDDDDDDLNDYGQFSFENIDKSKQIKRQKTSSNYKHDKNVDSNVESSSVIQNDQAKSKYGDHDDDTTLKLFVTTLHLTTFVKANTTRLDVNLGPSIEIENSSLQNVEQMNEPDKCQQFVSMKRLIIVDIYFKNQSERIGQCFDILQSPEQARIDQILSPLATIMICSSMMQEFGRIYKFIPKRNDQSQSFEENLSNNFLAIPFIYILFVKIAIHNLKNSTPIDLLTIELIDSIPYHFGILLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5G1</accession>
    <name>A0A922L5G1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5G1"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="1">
        <location>
            <begin position="15"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="75" mass="9270" checksum="21C0209AB0AF0370" modified="2023-02-22" version="1">MCINSTTKIITRSCVRRLYKDLLRFGRNELQYTNKDYFCQRIRKEFRVNRNLDRPEDIEYYYKKGLTLLQKRAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5M7</accession>
    <name>A0A922L5M7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cyclin-dependent kinase 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CDK10</name>
        <name evidence="10" type="ORF">DERF_007077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5M7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010556">
        <property type="term" value="P:regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07845">
        <property type="entry name" value="STKc_CDK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000533">
        <property type="entry name" value="cyclin-dependent kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000172">
        <property type="entry name" value="cyclin-dependent kinase G-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044093">
        <property type="entry name" value="STKc_CDK10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF508">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9516329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="340" mass="38851" checksum="CDF3CE56B7BAB5A4" modified="2023-02-22" version="1">MTTITDNTIYSFEDLSSFEIPKSHLLGSCDHVGDYEKLNKIGQGTYGVVYKARNIQTNEIMALKRIKIEKLKDGFPISSVREINILRTVHHPNIVEFKDVVVGKSLDNVFLVMEYCEQDLATLIDCQIHFTESQIKCLMQQLFRGLKYLHKNFIIHRDLKVSNLLLTDKGLLKIADFGLARNYGFPNDPMSPCVVTLWYRAPELLFQSNYHSTAIDMWATGCIFGELLLQKPLLPGQSEMQQIDLIIDLIGTPNDKIWPGFSDLPIAKTFTVKHQPFNNISHLFSCVSKAGIRLLNLLLMYDPWKRATADECLQSSYFRESPLPCDPSVMPSFPQSRKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5T7</accession>
    <name>A0A922L5T7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_009529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5T7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="974"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1007"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1050"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1085"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1114"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1147"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="661"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9511043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1180" mass="135869" checksum="C6EDE0C5624B7219" modified="2023-02-22" version="1">MNKNNLKLNCEPMAENISLAWRNLSYQVSGWFGSGKKSILKRLNGHVTYGSMNAFLGPSGAGKTTMLNCLNGTLRSGITSDSEIYLNRAERNQTPIIRFVEQHVHETIIARMTVREILHYAFRFKNPMSQWNRMNQHILSVLNELLLDKTILDNHFEKCSGGEQRRIAIAQELMSLEKPTFLFVDEPTTGLDSNAALLVMECLRKLAGNNRLTILVSIHTPNSDIMSLFDKVFVLAKGGVCIYSGPPNDLRNNLKQKIDDEFDTEKPPIEEYLDIACEAIGSEIVRKLTDSTLIEQHAQLDPLVDDLKFLQNGIRQGRKRFCWGDLILQFHRIFRISFIAEYKSFLMQFPYYFLVIMLVTTFFESKMTHAETCYSFESDESARNVTCRDKLYAEALADDYEMNQWFFIILFGMSIVSISSMFFDPILKVFRNEHRNQWYGLGTFYWAFIVVRFFQLTIMSVFIGTVAYFSVDHLYVDNYQMNWNRFGHYLYFTWLNNCYQQSIGYILCLIFLGKVEVSVVSSYIIVLCQQFFTGFMFNPYKMKTLPSIFLRMSEILSFKTVSNGLMYTMYGLDRCDDETTISFVLEDFGVNVDTVYSDSYFMIINILIIRLLVFVLMKKQIDLSKTVRIKKEDELGFEDFARHKIVVAWRSLTLFGTKSIYEIRSVEKEGPNSKQILKNLNGQFRFGTLNALMGPSGAGKTSLLNILIGKSKTRLSDTTKFYLSKFTPIRVCYLTQEVSGHLLPGLTAKQSLIYASMLKNAMENENLDHEAIAMKILKELDLVDTKDTYVQNCSGGQRKRLALGLELTSIRMPNLICIDEPTSGLDSSSAQVVVSCLRQVAHHHNICIITSIHQPTAEVFSMFDQVYVLAKGGVCVYSGPPSDIRQHLTKVSDRMDQDEIFPVEELIKYSCLSYEDPFIQDLVCLTNERILNDYHILLNETVPVLDGIPTNRNRFSLKSVWVLILRYAFYVRGYLWQTLCIMYCLYMGFGSAFNIEKDDEDFDLKASFIYAAFTNSVLFFLFLLQASIMFSKEIIFFRNEHRNGWYSTGVFYTMKLFTEIIPLIPAITIVAYITDIFEPIRPGMYWWMLLYFIINALVAQALGHLIAILTLGDFIALIIAMPAVEVISLLLSNIATPVRRLHYIFQFLSYFAPTRFGLEAILLLQYGFERCRKKKFKNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L703</accession>
    <name>A0A922L703_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L703"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="344" mass="39974" checksum="EED3C24BB269DEFF" modified="2023-02-22" version="1">MHAVKKVPTMHYNGHTKDKKSLMRVSINRCYVTVQKKRMRTSSRSSIIDQVSFIDWQMVHKIQFGKNRIKIVPNSKKFIKQKTIKAYFDKKVLNFLRKSCNKLNYIKPVKRRWFSLSNTKDYQPINRENSRTNSSSSSSNETCTMDSFTNDRSSSSSFNEIDEYEDGEDNVEQKQQQQRSDHHHQPSPDRISYRMDDDYDDDEFNNSNDDWTSFDDYSNLSFSFSSSSSSSLSSSSLSSSSSSSSSSLLNQSTNSVNHNHHQFDRKFEISPSRIEHPYSPYIHDSQKQNANVHYINSNPQETITPDYSSLFKSLNSLIETDDDDDDMINNNNNNKNKKRKQSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7S4</accession>
    <name>A0A922L7S4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7S4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="294" mass="34837" checksum="6C4AB87612FAD292" modified="2023-02-22" version="1">MIIIKASSLPASIEQPSDLVLKCFNGQLDLIQQCQQHAAGDFSPFGRHTWISTLWQTCCIIWEQLQCYQLNARRWCSPSLALQVIWYAKLRYQQIQQTLCRQIEWVRYCDHHDPIPVPNKHRFIWPLSKVTARTEHCLQQLKTHVIQFKNGTKITVDLANECNDQIVDKYEQKIQTMNITSEDTCCAIYELFGCIEHHVQTVCTKNDRKDWLDYQRRILDTISAMTMCRLYPYNSKELNRCQHRKPDNNHHHSHHRDHWKGNKLIKQMALVAFVIIMMIISIILYISYKRQCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8C1</accession>
    <name>A0A922L8C1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium voltage-gated channel sub KQT member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KCNQ4_7</name>
        <name evidence="2" type="ORF">DERF_005088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8C1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="125" mass="14563" checksum="788F797BC36A39F7" modified="2023-02-22" version="1">MTDISDDSISNQFFSFSDHTLPYVVNYQMKANRNAQVIVNIIDDFCEVKIRLNNKAGERYARSHGPFGCTPRPSSEVSRTSLLGRPIKPGPHRHHDPRYRKSQSFVYNFLERPRGWKAFVYHLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8T7</accession>
    <name>A0A922L8T7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8T7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="41" mass="4686" checksum="96C8FAA83EE00E32" modified="2023-02-22" version="1">MAASVRTPLQTVHESGPHEQLLFVVVIKKKHLTMMIMSQMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9E9</accession>
    <name>A0A922L9E9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
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            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9E9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9518052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="86" mass="10162" checksum="7FDE92F43529C37C" modified="2023-02-22" version="1" fragment="single">MMEMILFTLYRYGHLSKYNQTSLIQSLILYNQEQGKKQLEKSDFKIFERYSQQQKKIDPPGNIHMMMVNCGNNSNNNITIVEIITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9L3</accession>
    <name>A0A922L9L3_DERFA</name>
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        <recommendedName>
            <fullName evidence="1">XRN2-binding (XTBD) domain-containing protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">DERF_001642</name>
        <name evidence="2" type="ORF">HUG17_4729</name>
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    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Arachnida</taxon>
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            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <location>
            <begin position="15"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="88" mass="10751" checksum="FD9FB4285695435B" modified="2023-02-22" version="1">MSSNDQQYIKDEREIDQYRKHWEIEDHWQMRKSFMLAHYDHIVKDRLLCYAQLYVNIKVLQNEYDQALMNEIKALASKIPLANLKSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9Z7</accession>
    <name>A0A922L9Z7_DERFA</name>
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        <submittedName>
            <fullName evidence="4">ARF7 effector protein C-terminus</fullName>
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    <gene>
        <name evidence="4" type="primary">ARL14EP</name>
        <name evidence="4" type="ORF">DERF_000222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9Z7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029264">
        <property type="entry name" value="ARF7EP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14949">
        <property type="entry name" value="ARF7EP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="ARF7 effector protein C-terminal" evidence="3">
        <location>
            <begin position="324"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9526107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="492" mass="57691" checksum="012924F2361FCB9D" modified="2023-02-22" version="1">MDHLSTSSSSSSSSSSSSSSSSFNIPFNFDTVRPSPQNPIVKEMISKLNDRDYARFYGYSIRYRNDAFLFMHQIRKKGWDRKNDNETLESYQQLLKHPEWILFELIYKINQSRLIVTPLNAGDDRKMKLFYIEFLLSILLTIMLKMRALSMHKIHLLLETKKIYADLLKTMKLSEQDFLLQIDKCWLEDYFVKYDKNFELRFNIQGCYMTEEESEFIAEESNALMFGFRSQIHNSSDQELHRFFEMTKQRPKPIREYNGKKHELPQFLFIDSVCNSTPIFYTNDDDFQFEDEDDLALKNTEAFNNDLHRITLSTSPFPKSIHNLFINDKTICDCGRNDCNGCYPTCLKCGEKKCFAICRYNVNYSYYDVFHQAQTINKYDPLYKSKDSMNNNNVNQQQQQQQHRQQEDMMETDDDNSVETPVEQLSQSDSIDDELTILSTVPYGPHNHDNFSSEFPSQSLTGDEVESFFTCSPPTESNKNFHENNNGETNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAF4</accession>
    <name>A0A922LAF4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 86</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_002379</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for proper chromosome segregation during mitosis and error-free mitotic progression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAF4"/>
    <dbReference type="OrthoDB" id="277961at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026570">
        <property type="entry name" value="CCDC86"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13557">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13557:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0164">Citrullination</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9528429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="101" mass="12227" checksum="EB45A79B7F058AB9" modified="2023-02-22" version="1">MAKTKNKKNNSKPFRRNLVLDKPIRTNWKKKMQLKHENTQIKALEAELKAEKRTLIEEKRQRRVENQKRREENAKKAEIVQTIRNKNKLKKLKGSRKIRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB58</accession>
    <name>A0A922LB58_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bardet-Biedl syndrome 7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BBS7_2</name>
        <name evidence="3" type="ORF">DERF_005357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB58"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056335">
        <property type="entry name" value="BBS7_hairpin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056333">
        <property type="entry name" value="BBS7_pf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16074:SF4">
        <property type="entry name" value="BARDET-BIEDL SYNDROME 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23349">
        <property type="entry name" value="BBS7_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23361">
        <property type="entry name" value="BBS7_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBS7 platform" evidence="2">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="BBS7 helical hairpin" evidence="1">
        <location>
            <begin position="35"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9521725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="253" mass="28671" checksum="C451380B5061B3B8" modified="2023-02-22" version="1">MTSDNVSTISILKDFITREATRQSIEIEIDVDLIDKSLGSMLVRLYPNIRQLIRRKHRDDLLEALADLQSSDADIARQLLIDLNLNHQDGDDESIVDNLSSDNRRQDVMIGLDRLYGIITDLFIDYHKLKNSSMITSLVSMAKQKLPEMIEMIEKIVFDSFDSECMDMNNFSSTTFSIESTSIIDDDGHSITTTTNIDNTIDDGLTTTTTTNDSTNNNQTTTAKSSNTIIRLSQDPNVNIFIEKLFQFWNLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBF0</accession>
    <name>A0A922LBF0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_001733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBF0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="135"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9527727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="649" mass="74500" checksum="C96C4BAD70875E72" modified="2023-02-22" version="1">MKIIAIAISVEHSKLLHNNNRKNLSSTTTSTSTTSKTKTTTTSTTTTTSTTILNVKHLSGNQDLFYSDKINDNDDKDSIELPTSSKTNRQHEISTTLATISTLTTLATSTTVANNTESSSSSSSSLTAKKIEIISYCNDPGRPTKSQISPVQLTYVEDEQVQYTCDEFISLKQYRKCSKGKWLNEMPLCGKAFRHNDLVQAFIYEAENGFPKRLLNEYNLTNNLQPFNKFGNSFIAERYSHPLRAQGARDYYWNLLIAKPAFIQMIRISFSIVNHLVDRKLRSNVFDIVSVATNQYRDCKRVANNSVSPWHYNSTRFDYWYFCRAKSEDDFHKEIEQMTNQILIMIIIRIQFVDCPEVPVGLEARVINDQINYVFQCRKDFQRVDNYGGQFLTLQCGYDNRWHGQLPVCLPTRSCDKFVLENDEKHTYLVEVYKYDRVFYLNDTEWIPIRGSRAFFRCIDETNIFVGKEIRICDDGEWTNSLPNCLPTSSVKSEDSLKTSSILMIILSTLLFTFLMSSCMIYFFLKIRNQQQMGPNNNGGIMLPGMELSDAGGGGGGYYSTAGKQIGEEEYESIDYLDEHRYAPYHDIQNDQQHQQSLNEEQQSISDYYERMNPNVIRSHSNSSAPIVLDSYYDDSNVRPSYLAMRRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBK4</accession>
    <name>A0A922LBK4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GATOR complex protein wdr59</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">WDR59_1</name>
        <name evidence="7" type="ORF">DERF_003531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR59 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBK4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="97"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="183"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="371"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="783"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="783"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9529659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="948" mass="108891" checksum="F6D0F9C482BE9760" modified="2023-02-22" version="1">MVLGWSVANTTISHPDLHAMCLATSGNGKCALVSRRSISIIRTDNLAKIDSVINRETKWDTTHAEFSPPEPKQLAITNAQTINIYNIDESNWLMHTLSGHTRTITDLNWSYKEPTILASSSFDNYIYIWDLRETRKPIYLMHSISGASQIKWSKINENILATSHEGDVRIWDKRKSNMPLHYVSTYLAKITGIDWSPFYENKFLTCSQDGSIKLWDLTNCSKGKSEYHMTTGLPIWKVRYTPFGNGLLTSLVPQMRRTGENNSLWMWKINSLDQPVHSFAGHLDVVLDFRMWKVNPKEFVRNIHDSLSEDQQHDHTEDISSDFDTQSAKFSNLDLSKSSDLSSPMSEKCESNKSEFDNFEDKSDKVFSLKQEFSLFNSNIPNLMIEELNVNKRTCIASLKSSIICRLRIFFPINYPNTIPVFSFLNDTPIQNSHTVKSLDDKTKKEILTDLQSTATFLVQHNRNCLEKCLRQFVHLIEESTSLNLNNVNTIKPQPTVLDILTSHEYVSYLDASVPFPRTSGARFCSSEILVCFGRPPHLEQMNVPTEYTPRSLSALSSYLDNHVRAYNSNHMSVKDNIPSISSFYIDSSKKHRSFRKIHQYQEKKTVNLCGPVMVFSVTKLLPISRQLAEQYLIPSPRGNIISFCEMNAKIAATSGRRDLQQTWNLVRLSAEIYLKNRFISSEELNSHWSRHPFGGKMIQSMIEHYVLKCNDIQTVAMISSVISSCKLSWQEHVPSFVPRKHQPRINYNLSTQDEMSNQLDTEWAIINARGDVTGKNRIRTSSCSSNQEMNINQNKSDKSSTDSNEESNLNERIETTFDSKLVLEYDYYKKIYLDILYRWKLIKKRAQLLKTIESKMLYDDQSHIVSFVNECFTQSCKDRQKLCSNYICSHCNRISLICTICRLPVKGATNHCMKCGHGGHTNHMNDWFQKHEECPSGCGCFLRANAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBU8</accession>
    <name>A0A922LBU8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LGALS4</name>
        <name evidence="5" type="ORF">DERF_002264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBU8"/>
    <dbReference type="OrthoDB" id="5795596at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF147">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="59"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="4">
        <location>
            <begin position="268"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9528312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="409" mass="45396" checksum="97C78C3B33691F7B" modified="2023-02-22" version="1">MNIFTSMDKFVNDFVFFAKDLRNKVLSAIPATMASRSPHNIIDPTSFTSVVRNPSLPVCFSIPNGSLELGTLISIYATITSGGRRFRIDFFQGKCPHIYGDGVRCESNDNENNIAFHFNPRIGGGTDGRDVVVLNSFCDGQWGLEERHQDAFPFQSDTPFRMMILVESDGFKVAVDGRHSYEFKHRCDFRDIARIHIEGNLILDLVEFRKEIRYLVRTQSTSSSLTVDSTSSTEEAATPTAQTAAAATGGDISPPSGHSKLVTSPAIPYMEFDPNLSRPCDIYIAGMLPAHIRDNFVINLANSVEAEQSTAGIVNIPVHISIRADIQAIVRNTMTNGVWGEEELYLIGPFQLIPGTHFDLMISNREDKVVVAINGQPSFEYKHRHESKTIDSLQINGGVVLTSIRYENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCA3</accession>
    <name>A0A922LCA3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear hormone receptor FTZ-F1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear receptor subfamily 5 group A member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NR5A2</name>
        <name evidence="16" type="ORF">DERF_000149</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCA3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07167">
        <property type="entry name" value="NR_DBD_Lrh-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06944">
        <property type="entry name" value="NR_LBD_Ftz-F1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000032">
        <property type="entry name" value="Nuclear hormone receptor FTZ-F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016355">
        <property type="entry name" value="NR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086:SF15">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FTZ-F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="14">
        <location>
            <begin position="715"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="15">
        <location>
            <begin position="982"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="241"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="310"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="470"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="962"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="526"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="973"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9526030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1236" mass="134905" checksum="224263F9E22DFFDB" modified="2023-02-22" version="1">MASMTTTTMSADDCGVVVATVSSNHHHQQQQQQQDNDHMNLENSPTTTMMMMDSNNNPQHQQQQHDQQSSNVQRKESIDDDDDDTMMDESSTSIITSREMKCIDNSIMNQQQSLIKNTSNVGDHYCSCPFNLNDDDHHHNNDDVSNDMNSHHHHQTALQSLCRFCGLNIQSRINDTNEQLLLNNKTNNENEQENIDQKLPSSSSSNESHLINNNNDNQSLITIQDNNAKRKSITMIDTHQNHHQHIDDDDDDDNNNNNNNPIENNHQNHSNTNNNKNSDEMLFEKSTLANNSSDNNQTISITNLNSSASSSSLLLSSSSSSSSSSSSPPPPPQQQPQAPASSITSFSLSSSSSSSSTNIADDNISKNDNNQNRSPTLSILTTSTTTVSSILSVSTTTSNSSLSTTLTSTQSTSSVSLNSSITPITTTSTTSSIIVNNNNTDQIINFTQPTIISATNVTVLSTTATAATTATTTTTTTSTTNNNNKSKNSMLPPQSTPNILLNIKSEPESPPDNLKTAKNNTANRLNQSHHNQQQTQLQQQQQQHIQHQTQRQLSSNSETSTENNTNPSPPAPSSSSSSSTASQSPANNLNNSNNTANTVSGTMLASSGPLTANTPNNNHMMDYHTQQQQQQPPPPPSSSLTSGHHHHHHQQQQQQHHQPQMGGGQHPNLTLTTPQQQQTMLPLMGNNNQQPTISVAAVVTAASSSPNSDPKDCIEELCPVCGDRVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVADRNCLIDKSQRKRCPYCRFQKCLDVGMKLEAVRADRMRGGRNKFGPMYKRDRARRLQILRQKQLSKAHHVVGGGNSLGPPTTILPGSAAAAAAAANEALNFLNAAPGSHGGSIFDGVKPELIQIPQLSSSTSSPDSSPSPGSTAGVAAAAAAAAAAGQLPNAVAAAAAAAGHPHFMSPLVPSTLQQQSSNLAGANLSQSMMSAGDQHVMKWGPNGPGPSNMSANNTGPSGKSGLQQQHYDTKLVMPPLIRELQLSMLDDKEWQSQLFSLLQNQTYNQCEVDLFELMCKVIDQSLFAQVDWARNSIFFKDLKVDDQMKLLQHAWSDMLVLDHIHQRIHAGLPDETTLPNGQKFDLLSLALLGVPQVADQLHRVTARLQELKVDTNDYICLKFLLLLNPAEVRGLTNFKLVHDAHEQTKQALLDYCINFYPQITDKFNLLLALMPEIHSLTLRGEDFLYYKHMNGSAPTQTLLMEMLHAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCD3</accession>
    <name>A0A922LCD3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein asteroid 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Xpg and nyn domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ASTE1</name>
        <name evidence="4" type="ORF">DERF_003091</name>
        <name evidence="3" type="ORF">HUG17_5108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCD3"/>
    <dbReference type="OrthoDB" id="25987at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7642063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9529197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="693" mass="81568" checksum="814492C3C42775BE" modified="2023-02-22" version="1">MGVQGLLSFMNRNDYFKIHQLKDTVLVIDGYNLVYQQFFKYQQNVNDHMYGGDYDQLARHVQQFFKSLLKCNIQPIVVFDGAIDPSLEKLKTLLKRVDIALNNAHKIYANNYFIEGVMPLLADSIYRLQLERLGIPVFQTCYEADQTIIQIAYDLECPILSNDSDFLLFNLPAGIVNLQSLFDFDVVVNRDSDDHYYIRCRYYCVENLKRPYPKINLDLVQIIGFMLGNDYVDNETMAMFTRRISSHKDRQKLINDVFIWIAKHDTLKSLIGHMGVILRNTDHHLIEIIKKHYLLLERSIHTQKPIDHRTYLEENISRLFIENINIPRWMRSKFVHKQIHCRLLSIINARIDWCRPLVEDFSYPQSSYETANELLQCIYGILRSQDKNTAKIKRYCRKNMEFKAHAITPIINMEKKLLPKLSAIEQMDSQERKSLFFQILQIKPEVYESLMKLLDRLKTCCSIDHSTIIIPFSSMLLALLYMLRNFPDHIWLEFVYAIFMNIWFTGYLCHGTNGPIFLKLDSISRQTIQNNLIQFSSLPVLSCSKVYMPRLVHFYNSFQTCVDNIDFLGQIFNLKHIFNADIMLCALKGTFIYNLTAELCSRPKPFLYIQQLLQRQKFKPLDILIEMFNLILHESDRYMLAKNRLLADSDIVTKSLKCKITNTITPNNKYFVRAFDFTSKKTHVNSQKLKLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCR7</accession>
    <name>A0A922LCR7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCR7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="14163" checksum="5F4FDBA1C12EBE52" modified="2023-02-22" version="1">MFVVLVGWLVGRSSSLLVGFYPILKYSRYMGDLYITNDSYFVLFNQQQQQYLSTNKFIFNFQTQSLEKREFNHHHHLQFKPFFLKKPPPPPPQPRRRQLPSSSIIIFTASLLLFVDEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDI6</accession>
    <name>A0A922LDI6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDI6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7970" checksum="3CE4763824410766" modified="2023-02-22" version="1">MIMLMNTFKSYGLLNNFYHYHHHHHHVFGALFSSILNTESFQVVKCIIKVEKTNGQFLSDQMKRKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDT3</accession>
    <name>A0A922LDT3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RCC1 and BTB domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RCBTB1_4</name>
        <name evidence="5" type="ORF">DERF_004148</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDT3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="145"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="195"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="368"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="625"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="675"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="728"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="848"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9530335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="985" mass="113109" checksum="8799CC12411EB0F4" modified="2023-02-22" version="1">MARLPNENIDLELFKDEFKNIDQEFLPSVVSIFRLFPFIDIEKEFLLMTKEATFAYGEVICSSLSLEHDMISPRRISCLDDMTIVQVDSGADFVAILTDDGRVYLASNDSNWKTNNTFRLINTGNDRFKMIACGWHHLLLLRQDGHVFAVGDNSYGQITGNEESSYQSIIKIDNPENVKLIACGEYHSLSTTNKGKIYSWGLNHWGQLGYDDENNRNTPCLVPFPNDDSTRIKDIVAGMYHSLFLFENGQLWGCGSNENGELGLGDDIERSKLAKIPIKNVQQIACLKFNFLSLAHDGSSYYAWGRTKYGIWSSPVKLDDSHSSFASASVQVLDSPITFGLTSTIYVFGSHDSIYKSIIRLFNNPDNYDVKFVIGDKCILACKCYLKSLSEYYCRMFSGNWSENDQVIINDYSYETYHAYLRMLHTGEIRFNHQIITELVDLANCYGDERLMEYCKTFIWNDLNKHTISIYHPLIRKYEIKELSAIDNIDIYLFQDDFKNIDQKFLQSVVSIFGFFTFKKYKQFLLMTKKATFAYGEQICSSLSLEYDMTKPQRISVLNDVKIVQVDSGYNFVAILTDDGHVFIASDVKSKWKTKRTLRLISNNNDRFKMIACGCLHLLMLRQDGHVFAVGDNSYGQITGNEESSYQSIIKIDNPENVKLIACGEYHSLSITNEEKIYSWGLNSCGQLGLGNEKNKNTPCLVSFPNSDSTQINNILAGKHSLFLFENGQLWGCGSNYNGELGLGDDIKRSKLTKIPIKNVQQIACSRDHSFSLAHDGSWYYAWGKTKYGKWSSPKKLNNPHSSFASASTMILSSPLTFGLASTIHVFRSHDSFMYKSILQLFDNQDNYDVEFIIGKKRIKACKCYLKSASEYYQRMFSGNWSENDQVPIENYSYETYYAYLRLLHKGKIHINHQNIVEIVDLANCYGDERLMEYCEIFIRNDLDEQTMPTYRTLIIKYEMKELYNKIAHLDKNRQQSSSKRTKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-12-02" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A7D4W6V2</accession>
    <name>A0A7D4W6V2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome c-2-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Cytochrome c-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_013637</name>
        <name evidence="13" type="ORF">HUG17_1012</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <title>A chromsome-scaIe assembly of Dermatophagoides farinae genome and transcriptome supports identification of novel allergens Derf37 and Derf39.</title>
            <authorList>
                <person name="Chen J.-J."/>
                <person name="Hou Y.-B."/>
                <person name="Zhang Z."/>
                <person name="Hu J.-Y."/>
                <person name="Cai Z.-L."/>
                <person name="Wang H.-N."/>
                <person name="Ji K.-M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="5">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MT360914">
        <property type="protein sequence ID" value="QKU37013.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A7D4W6V2"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7645474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9497669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QKU37013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="106" mass="11656" checksum="25917680E3873C33" modified="2020-12-02" version="1">MGGGNAEKGKKIFVQRCAQCHTVEKGGGHKTGPNLNGLIGRKTGQAPGFEYTDANIKKGITWGHDTLFEYLENPKKYIPGTKMVFVGLKKAQDREDLIAYLEESTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HGU1</accession>
    <name>A0A922HGU1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HGU1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="75" mass="8329" checksum="19DC398F542871AC" modified="2023-02-22" version="1">MATGEVNPLPPPPPPRLEPLDDDETGRFFVPPCCKLGPATIANNNTVDKNRAILIRIEIKSMKKKLNTMMLMTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMR4</accession>
    <name>A0A922HMR4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMR4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="160" mass="18194" checksum="11306E4C37F97B42" modified="2023-02-22" version="1">MAESRFGILYVITRILLVVLIVIMIVLNIIAIVNAKGEVRDVVWVVFSFISLLIGLLGVWKEHFLFSCLFTVIAIVLVCISGAFGIWISTAGTVVIIITAIIYTFMLWDMGHREMNVPDITRKRRQRWMDLGVVKINEDLIDKNPNQIMESNQSINQSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMY2</accession>
    <name>A0A922HMY2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMY2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8679" checksum="5A75D956DF4A2D19" modified="2023-02-22" version="1">MDDHVFPASLANNKLRKDYSFQNLDSLIEQILMAWLPLYNIFTYEIYMSKSNDDNDHDHHIVLQQKRPRKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMY9</accession>
    <name>A0A922HMY9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N-acetylated-alpha-linked acidic dipeptidase 2-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_015892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMY9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="406"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="3">
        <location>
            <begin position="812"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9491159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="962" mass="109819" checksum="299C0E3F760B4412" modified="2023-02-22" version="1">MTLTAQYRPYRDEECTDVDHNGWPEHEPAIQIYEKTTETIPYHVYRNKRSIILILSISACIGIFGFLIGYFSHSNHLSHTNDCLQTKVISSSFDEANLSSSSSSHIAGDSALRRAQLLASISSENIRINVREFSRQPHLASSNEDLDLANKIRDHFIHNHFDYVTLKNYSTLLSLPDSNRPNFVALVDSISGREIYSSLSTSNQQQQQPLPFSPYSPKGDITGEILFVNYGRPVDFIQLQNLFNTTSNEIFNGKIFLVKQFHLSASEQYRYAAALNASALLLYPDPQHYNPRQSKPFPDSLWLPSDGIRNDGIFWNGAGDPETFGLPSNSYAYRNRFHPERQLTIPAQPISYEMAEKIFNHMDGMIAPNDWKGGLNLTYRIGPKLKDNLKVRISVNNRLVRKTIYNVIGTIRGYDEPDRYVIIGNQRDSMTMGAIDSASGTGTFMEMARVFGDMVANGGGWRPRRTLMFCSWGGEEFNLIGSTEFVEDLYKILYMRAVAYINVNLVVNGNDTLSVAASPLLYHSIFNATKDVFLPRRSPSSSSSSSSKQQDDFNSIYDKWIVSMPKMRNKSTLIFQSNIFNHMKMFDIENPTDISEKEILGNKNYRQFHRQETADPGSILKTYLESAFQEVRPHVRPLDMYGSYAPFYTMAGIPVADISFINIDDEMNVNDDNNEDVERITMNHIPYPLLHSQYDRIEALENFIDPDYRYHVTIAQILVHLVENLSNSSFIPFNLFDYAQILKDFYVKTLHMYNVIMMGRRQQQQQQQSMSMSKNNGNIVESIIENGEIINLNSSSSLMMIDSNEFIDMMDLDLKSLESAIKNFSQEAIKFHGRQDKIDLNNPLMVRQLNDKLLLIERQFLDHRGLPSNNLKRHLILSPSEMINTIMPKHHYDGNDGGFFPAIIDELDQLMGTMFNNIDDGDGDDDDDDLKHSLIRLQKHLPILIHTIQSAANSLSIEPFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN66</accession>
    <name>A0A922HN66_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN66"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="95" mass="11025" checksum="7B3A31AE8524C190" modified="2023-02-22" version="1">MYICYNEIQRQLRLQQYKQAIVTNKKRSSRSHHHSTTETTPIPTSAIHNDGDGMTTTTTTATAATMMMMVTQQRPRCRTGWPQHVWALELKNYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNZ5</accession>
    <name>A0A922HNZ5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNZ5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="9684" checksum="EBA1A0CD1C246599" modified="2023-02-22" version="1">MSYKNRKKNIKQLLVIRIFFFNFRNNKLYYGVESKFRNLLNASNSCMTRVISVVAVISGIEVEDDGVEVDDDDVEIDDDDGDGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP37</accession>
    <name>A0A922HP37_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Superoxide dismutase</fullName>
            <ecNumber evidence="6 13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SOD2</name>
        <name evidence="17" type="ORF">DERF_012169</name>
        <name evidence="16" type="ORF">HUG17_8948</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="6 13"/>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP37"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000003">
        <property type="entry name" value="Superoxide dismutase [Mn], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="34"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="121"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7637844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9501315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="231" mass="25814" checksum="A789B4715EF8B1D4" modified="2023-02-22" version="1">MLSLIRTSSMIRCPSILARTLNVPSTQQQCTKATLPDLPYDYNALEPVISTEIMQLHHSKHHQAYVNNLNVALEKMEEAKSKNDVKTIIELEPALRFNGGGHINHSIFWHNLAPVGNGGEPKGELLQAINSCFGSIDNMKARVSQLAIGVQGSGWAWLGRCPKSGQLRAVACPNQDPLEPTTGLIPLFGIDVWEHAYYLQYKNVRPDYVNAIWKVANWNDIEQRFMAAKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQS0</accession>
    <name>A0A922HQS0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hepatoma-derived growth factor- protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HDGFL3</name>
        <name evidence="7" type="ORF">DERF_013074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HDGF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQS0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05834">
        <property type="entry name" value="PWWP_HRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036218">
        <property type="entry name" value="HIVI-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021567">
        <property type="entry name" value="LEDGF_IBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF70">
        <property type="entry name" value="JIL-1 ANCHORING AND STABILIZING PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11467">
        <property type="entry name" value="LEDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140576">
        <property type="entry name" value="HIV integrase-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="6">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9497063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="619" mass="71637" checksum="6E44A21ADC7B94CD" modified="2023-02-22" version="1">MPPKPIRNYSVGDLVFAKIKGYPPWPARIEEDFPIGYKPYPGRYPVFFFGTYELAVVSAKDIYPYQQYKHQLGIPRKMKNFNEGLEEIEKHPNLTMNSEEMLRLRDERELSGHNNYDDESDVSFKKSDVDDSASFDDDDDDDDKSISNDDEEDYSRKLSKSKNDGKKNRSSSNRKQKNVQSDEDSNDDELDREKSVKNRNRKNIKKNSSSSSNNNNNHGKKVEKKNSGKFNRSSFMLDNDNDYDNDENNVKNQKKKPNIGKKRKIIKQSDSEVEISDIDDDDDNENDNNSKANDIDSPKDNDDEHHSKKKKNKRLKISSSSSSSSSFSDVEDSKIKSEKRRLTIHDDSDSNDSKSKENAHNNNNNNNNSNNNDDDDDDMIQTPKNSTMTETIEDVMKLKQKLQDEKLTQKLEEKEREKERRKREKMERKRLERLQKAKNRNQEDSNRMINEMLATIDSNIKLSLSKTNANIDKCLETMDSIDDVKMKITSKNVSNFGDNLKELISSLKKCRKYKPEERVRQKADHFLNKLKELFSSTESHSSQEFRTISDSGNVDSKTNDSMPSTTTTTIDEQLAPEQRNEETMIDRKSSENETENSKLSATIEQLESKLQPITDEMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQY3</accession>
    <name>A0A922HQY3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQY3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9502089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="8104" checksum="8DC1437BC21A63B4" modified="2023-02-22" version="1">MNIYFSLYTQTIIFEFIHPHPHNNSVLPNHSVKQTSKHDSEFVFEYKSYLKMIVIQPNLWPLLLTVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HR53</accession>
    <name>A0A922HR53_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HEATR1_2</name>
        <name evidence="2" type="ORF">DERF_010602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HR53"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9505830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1070" mass="125593" checksum="B99855E34B2CDDEA" modified="2023-02-22" version="1">MASNTTSLARQLEKLKLPQTSSHNERFGSVSFLYDFFQAKTIDLDTHYSTAIISLENLIQIDGHFRSYKTTLFHESSKKFDRAIENKETNKQLNDQIDEFLFRISKYFQLTDAHKVLEYMIQRYRINEYNVDSLIGAFFPYHETRMFVRLLQTCSVIKNPRNYRFYWMKKFQENGVPITKSSLLKHCIADLEFTHYVTDSIFKALRYDPDNSVFPSFLLSFCLNLLQRSTKDMIVSHILSVISRCIRREDKQLFIVAYTTFSHLCNLIRLEITIVEKILKSFFHPKLTISQPTLIAFEIIIKCQDITVLPKYFVQNNFINLLISLSTDLKLEHLPRAVILNILMQNDSNKFDAQTYKNYLHVLLETFANSSDTVMSIVSWMNNFDNVDDNSLSHQFICHTTKLLEKMYPDYFDLAISSLPMIRNLSKYLKSIRYSLAGNSKTPLYLGVEHSSEKIRQQSFLYLAKNFTNLIENLDINDMRFIRTILLKNLAKQDFQNQKEKLEILLKIFKVKDKIFNILTDEEFEKITLEQMRCIQSQITDPNVENDVDLFKLFIKLKHLLIEIYCTKSYGDYCRDFSTEDYYLGRLLNDEIQQLMILCLLSTDYQLSTLILDSEYAKTNPLFQIIREQNQNFITFDDFKMLEDEKQLEQLKLFSLNILNGIALFLNQNQRRLFPKPNILQSLSSNSNLRFKFLLIYSMIKMLQNHPIDCGEQQGQIVCQFTVDLFFHLLNIGINISSRSEVKISSVNEYAKMNMDDYFLYELYNFNDKSISLLISGYILYCLMNQKSSMNDDLPSTADWYLTDVGNNMINYDFYYKIYCLLMYYSTPNEMKPISKKIYKFFRHLFSTFIMEKIQNHHAGLKFFLPSIVNHDSSIQQQTLIVLVNLFKHSSTSTSSILIDSLCTNSQYLVAYLLALTSSKTSTRQMAISNIKQIVMNEKLTNGLKSFIQIIIDEQQSLILTDENAITILLGRLQDHPIVNELLQTIIFILTANGSKIKAFHKVALLKLLRYCNLKIKSIVFEYYTDFLSSANKFIDLDEELQLKEIVHYYDYKIFDTSKNCLMKIKKIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRE4</accession>
    <name>A0A922HRE4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import receptor subunit TOM22 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_013373</name>
        <name evidence="14" type="ORF">HUG17_6040</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRE4"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7643678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9497378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="196" mass="21815" checksum="7AB3D8C87334D36E" modified="2023-02-22" version="1">MSSETNVQSDLTKEQQQQLQEEDIAIVDDITVLDKPNDDGDEPKNIEIADIDGDNIVAPIQKESEKSTAENVPSGTVAKIITIMNDDIDDDDDDEEFEDETIVERLIGLTEMFPEPVRNYTWKFSTGSYSFAKAFYEFSRSAVWIISTTAIILAAPVLIESEKSQLEEMNRQQQRQILLGPSASGATPSLTPPTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRZ3</accession>
    <name>A0A922HRZ3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRZ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47533:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47533">
        <property type="entry name" value="PROTEIN CBG21859"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="86"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="365" mass="42948" checksum="B4AB45DE1D6A96D4" modified="2023-02-22" version="1">MLLQSSCCWNAARLFTTIFSRKLTNQVININAHHVRERQVRVCKRFGKNSWLLRPWFLRYIPHDGYPVNIRYVDTSPDDDNSRPVILLLHGTPGSYYDYFRFIADFGDRYRCIAPNFPDFTHTIRTGGCFWHSAEEKSEFIADLLADLNIKRVHCLVAHSLSAYAASYLWLYSNQQPYFDLDSLCLISPVGRFSFRWRQRVRMRLLSQACRLLYLRKMMMPSSSSTTWLLQGQHIPRTSILGNRHLAMWKALTENLSNYDSYHLRLRVLSGNLQIPTLFIYSSNDKLYPAIVYHNQLYELQVEGDEFDRYEHYENRLVQTAAIDRSDSWIRVVDFSGGGHYLHNTHTHLIHSYIDELLNRVNIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS27</accession>
    <name>A0A922HS27_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_010962</name>
        <name evidence="4" type="ORF">HUG17_9469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7642778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS27"/>
    <dbReference type="OrthoDB" id="10052888at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324699" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7642778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9506221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="769" mass="86343" checksum="DFAC0E0A474B892B" modified="2023-02-22" version="1">MIIVFKFLILVMMATDSQCLNCLRTAISIVAMLLLQAGSFNSIHCYEIYDPIDQMADESVVTVENHHNHHHQLPPASNISIQQHKVVDASDDDGQVGFDCLNKTEGYYGDDRYCDMFHYCKADGNRFTFACPADSYFNQESIACERMVDLQRECRNHTGDTLVSLFSSTTLVPPTNYVESPITTTTASNNISTSTTTTTTTTTELPFRINPIIKSNLTNNNNSKPLVKPPLANLTAKFVPKPEVPKLSIDSGIKNIDIMTNEDDVHSLFNQFDMSSSDFQPYMWPQPESDMTRQPSIQSSPQEDHEHINHSSSDARQSLSVSIQRFLRDNVQLPSHFIRMVPRFWRHLQSSLLRTENNLNNKPPMIGQDSNIVPVWNKPSTRLQQRFEEQKSMATENDDDNDDENKLAGLSTLSIPVLIPINLTREDYRQNMATSLLKPIVIPLKDRGKLVPAYVLRFNQHRLKKRSSVPGASGKDENNNKAAGSGHKKLLPKLTLRSSLLTSLIPPLLRNKLTKSMMAKQKPESTDKTPASKSNDASLMMMAAALANNNAFLPLSVYGPWWTPESYTFIQQQLLKAAESSNHPVFENGNAAYLPSSYYTKVTGKEQAHPTTYPTTKQLFKTGKSLRSANITTSSQSRPKTINRKNHATISTNANVYVPDELFDDHQALTDSRQQQRNKNHESSGHRPSNRDMAIVNGTTLSIVAKKTNEHRGKSPPDDRFTSTVSASMMVGRFTAPNMTEASTTLNRDYESESKLIESSSSNHRRRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSD4</accession>
    <name>A0A922HSD4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSD4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="99" mass="10917" checksum="EFE5495AF7D0A62C" modified="2023-02-22" version="1">MDHFIFVIGNLIQFVRFHPVQQHNEKKISKTNNNKKKTKTKNDHPDEKPDVKMKINTYGIGTGIGSGKNFFLLIDAAATAAAAAALIPLLTGNDQQILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTZ0</accession>
    <name>A0A922HTZ0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTZ0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="7100" checksum="80C5B07F470A0188" modified="2023-02-22" version="1">MAILEYQKLYDQRIKILFVRLHCRNMIAPDGHLDKQFMTMTGTLIPICFSINTIIYKSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTZ9</accession>
    <name>A0A922HTZ9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 208</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_009440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTZ9"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9510950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="178" mass="20844" checksum="A3091CBE1BB3E010" modified="2023-02-22" version="1">MAGPTKGGGKQATKGQKQIYLENKETIKHYTYMSSISTLIYLILMLIYWRDLLFTFKYILGFIYCIIVHGFSLSMMKYMAKPVFNSTGSLVDGGTDLNMEKGFAEHFKDLIIINSLIQVLSLISNYFWYCWCFVPIYAFYSLWVNILGPWFFAPPPPEEQVDEKKQRKMERKMRRVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU38</accession>
    <name>A0A922HU38_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU38"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037826434" evidence="1">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="6654" checksum="9CDF1BB1571A29D8" modified="2023-02-22" version="1">MHQSTMMANLLLWSKLASVGYVVETVAPIALPKRRHDFNSALVTYSLSSSIVISSLGSTSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU54</accession>
    <name>A0A922HU54_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU54"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="901"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="953" mass="112328" checksum="61970252A4238486" modified="2023-02-22" version="1">MTDTNSSHNPQELTEQQIREIKDELNLVQRMLDHKIKGFPSQTTEDQLTTMKGEAKLFKEIIDRHMKHYPDGRPTNPNLPRIEILTEAIKTALLYRNEIKNRLKPFEAAREIPNGNQYRLWERPEQNNESHSNMGLESTRQWRTHAYIPSNQSDKKFSDRMLTMVQHFDGSFKNFPEFIQNFNTFVDKTNACDDTKLCCFRKFLDPFSKAMIAGMNNYVESYLKICDYYSNPSLIKEEVIKDLRKLPDIHDYRQVKKMVDNLAIIRTKYNQLASIPEHRSFMEREFLGLISRKFPREVLEKSTHLIRHPNRIHTFMTDAEIFVDNWQEDFATREAEYYYSERVMNPGPSHHQPERYPHDRRNNRNYFHNNQRNRQPMSRPFQNQNNRLNYAPQQNQHEQQNQNQAQARAPSCVFCGGEHPQRDCQLSLTMEILFINILIMTTIFISTPVDGSHLDNSGYPIIWRKSKHHLATQIVQAEIKIKLQNPCSIVDRLRVKAKTNATHFLNSYNWESCVRGYVKRITKPFRHYCPNNAAEADHSIQKRGIINFVFKTVKWVVKMTAAIGLVGVIHGIGDQIFPDHDEIDYKTLETQINNNFLKVITKMHQNQLELEQQVREVSIMSTLNSRFIEMENTIKQMFRPDNEQLAWQLKTLFPNISLGHETMDEYWTMESCQLKEEEGVAYDELVLFVNAIKMDPEYSLLRADPFYIVHEETAAELLERRPEFCLSEYIGPQYVVYHQKTRCFREIPFNPIADHQTLMLFHSELCKAPIKTENVRWRKTKCESHSRFISEELVQIKWDRHFVYYYCYTQNITRGSQTVPCRNQVYKEKRGENVTINGRTVFAKSLHLESFSIIGTEVSDFVNEEVFDSDELKGDLKNLESLVELENKLVTKITTTYVRKASLLMVGGTLVVIMALAILYITYQCKKTTKNRDQRAREFRELMRSNKLHQEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUE4</accession>
    <name>A0A922HUE4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUE4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7389" checksum="EB6B5F12A7135954" modified="2023-02-22" version="1">MIVMIMRSHPQASLIESMNFTIELYLSNILLQQNRFFRILFHKICCCCQKFSAKKIKDFSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVI8</accession>
    <name>A0A922HVI8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LPIN3_3</name>
        <name evidence="3" type="ORF">DERF_009003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVI8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="2">
        <location>
            <begin position="362"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9510483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="582" mass="65562" checksum="2C3C41FE046C338C" modified="2023-02-22" version="1">MREIESINGPISIDPSGSKDDDKGIYLDELDPNDMNPEVVAKYFPKFRSSLTTKPSNILTATSSDDDIESGKGASLSNSPRSADFNYQQPETLHSDFVDRVKEQLMIPGDLYSLSRIYHDMSMSLCGHVEDLIENPDNTERFLQSIISFDDFNENPLQILDNPNLVIRMGSEYYTWKMASSMVLSLLLFQRPLSDKTMQVLKEKCIPKKVNNQNARSWRSWFRSPTQSESNHQQSTEPAATTTIDSSSSSNNIHTSGANVTPTKNSNNNYSSNSIEYVSDDETYNSVIISNNSARNSTTSKQDSNTGTKKKYRKVLRLSSEVLKKLNLRHGCNKIMFSVTTAYQGTTACESKIFLWRHNDKIIISDIDGTITKSDVLGHILPYIGKDWAQMGLTKLYASIGQNGYKFLYLSARAIGQAKGTRDYLTSICQDGQCLPDGPVLLSPTSLFSALHREVIENKPEEFKISCLKDIQSLFPMNPLFAGFGNKINDTWAYKAVGVDISRIFTINHRGELKLEKIRSFRSSYNELSQFVDQMFPPLNKDRLVEPHDDFNSFLYWRTDIPIIDDNELIGSTNGLSSVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW32</accession>
    <name>A0A922HW32_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_011783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW32"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9507080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="790" mass="91411" checksum="D5E6366EFBBB78A6" modified="2023-02-22" version="1">MKCPLVVANSNVFIIISIVVIITISTCHCRPDNDKQRIIRINSLDRIHTTENHHQYESINDGRIFLYYFFKYYEFVRHNLSQECRQSYDYFLDNSKEKWAMKMIDSNSVLESGLMDGNIQFFGEFDQCLDLTIDHLPNGQIQYCTIQFPASIIMTKNESDTFPSFIFSMVPPTASICIPAACSIHHDLPVILNELSIRDNQKPLTITQCITRQDLKIGNRIETIHMVIIALFATIFTMIIIGTIIEMNQLNRLSSSTSAKNFIIRLLLCFSLARNLGFLFRTKSYQPSTKTTTTTTRTPQIDCLHGIRVLSFLFILIYHTFTEAQIPSANLLKVLGVEHGFLYQFITNAALWVDTFFLLSGFVMAHSFLNQYGRISNSSNSNNDSNNNNNNSSNDPNRQNNKRNPSIIEHLKQHPRRIFHRYIRLTPSVAGVVGLSILIEILGSGPLWRNYVNLSQQSCHKNWWNVLLYINNFCNLNSPTNPQSECLSYLWYLAVDMQFFIISPLLIIFLAYESYRMRTIGIIINIAFILSSSSLTAFLMAWKHLTPTVLVTVYDLDYINMVYKASYCRIGPYCIGILMAYIYHRRHFYHQQEYLINNNDNGDDDDDDQNNQIKNNRSTATGSMLLVISIILMFATTMLTYPWLQGADYINALSILYGAIHRCIWAIAWALFIWAMARQHLPLVDRLFSLPMFQVFSRLTYQSYLLHSVLISAIITSVRQKIYFSELNLVLNVICYYFFTQLISIIMFVMFERPFINIESTFFRNNHHSSSKHRNNISTNSKGMNPTMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW62</accession>
    <name>A0A922HW62_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW62"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7488" checksum="ED9474429D3583B9" modified="2023-02-22" version="1">MHINPRKWKVQKYQIKDMRQEKMKNDPVNMINQSMIVYRNMIDKFLSDIRHGGGATTFTSGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW81</accession>
    <name>A0A922HW81_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW81"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="8328" checksum="FEA9B55D68E34CD3" modified="2023-02-22" version="1">MQGVFFLFPFTFGLIIRQCKDNTPIGFNPRVASIQFSSSMISSREWDNQHHQHLSDKNPIPFTATFSACLANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWL1</accession>
    <name>A0A922HWL1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWL1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="202" mass="23324" checksum="BDFCBD399438FADE" modified="2023-02-22" version="1">MEFVHNQLVDQIETLKQSLKMAEETMDVLNADENLSSSSSSSSTTEVEKDKKSSELEFFDATKDIDLKTAKENIEKLVDENKVLREKNEKFGKLFQKLYDHLETKLIDVATKLQSAIESEEKKEKLIEQILVKLQINDDEHVSDDHVLHLIDELLVMKQEFIIMNQAMNKLQDDLKQSKDLATKLQSAMDGCKKFLFLVEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HY84</accession>
    <name>A0A922HY84_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HY84"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="197" mass="23775" checksum="A51F6009FF911B5A" modified="2023-02-22" version="1">MILSIKFKQIKTRWMKKNYESINFDIKLICKIRNRTIQLLILTESVDRTYAVLMFLIILVNGPMNAYVTMIITIKSIPFTEQLLFLSMSIYQWSFIFLFHYTAIRFGQNIHYPSKYFINHYYSLTQPNNNNHHHGSNSKMVNIRDRLQLSHWFEKFHTKRCYGLTYGRTNLITMNSFVRFITFYAKFMMIAYKLIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYD5</accession>
    <name>A0A922HYD5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYD5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="89" mass="10401" checksum="6968B69CFAD7A836" modified="2023-02-22" version="1">MNKAHSMPSLPFFFNIKIYTYIHFFPNTETKTKRLSHNNGLATYFMIMISNEKQFKNSLPCIPVTIMYYICIGPIVIAVTKFSVWVTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYU8</accession>
    <name>A0A922HYU8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYU8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="10377" checksum="B77B8781152ED551" modified="2023-02-22" version="1">MDLLENIYETNWAIYKILFRNETKIISRFQRENKQYHGHHQVIQLLCLQMSDNFYDNKVVQRFTGSNYRKKNQKINLKNQNLIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ11</accession>
    <name>A0A922HZ11_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GCM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_006730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ11"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.670">
        <property type="entry name" value="GCM domain, large subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3530">
        <property type="entry name" value="GCM motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039791">
        <property type="entry name" value="GCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036115">
        <property type="entry name" value="GCM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043020">
        <property type="entry name" value="GCM_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043021">
        <property type="entry name" value="GCM_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003902">
        <property type="entry name" value="Tscrpt_reg_GCM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12414">
        <property type="entry name" value="GLIAL CELLS MISSING RELATED/GLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12414:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR GLIAL CELLS MISSING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03615">
        <property type="entry name" value="GCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90073">
        <property type="entry name" value="GCM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50807">
        <property type="entry name" value="GCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GCM" evidence="7">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9515962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="582" mass="68470" checksum="E9D72B244BBE8110" modified="2023-02-22" version="1">MKLNGKLSLKQNGNVTQFDEFQEWTDGHCKFVYRLDCEEARRHSSGWAMRNTNNHNVNILKKSCLGVLVCSKRCILDNGQSIHLRPAICDKARKKQQNKSCPNRHCNGRLEVQPCKGHCGYPVTHFWRHTKFAIFFQAKGNHDHVRPEPKSKIDARGFGIKYSKSSSSLASKSSILLSSSSLFAIQKLNNSTNLPKYSTKQRKVMMMMKKDENNKSNNNKNSKQKLLKTIVTMQHQHQQQKQQQQQQKQSDDSNIQYLNYHFNNNDDNYDIDNRNNLLMNNNDHTNHHHHLISHHQHSNMVYYEQNNLLIKQEYNSNCFIYHNNNDTNYQNFATTMNPTSNVNSTKSSVHTEELHGDQFRNILQNLQPPSTTLNIEFLPIEENFEQFCPEQQQVYNQNCCSYFSTTPTSSNDVDQYSDYNHHYPHHQQQQIDPITSNNDNQLQFNDESNRCMTNEYDGSNHHQQPQYSHTSHSFDHPYNDYGTLNSDNTNAYNNTTDTTYWPSMVNHHHHHQHQNDEQNFTMTNPYYPTISYPKDYDYSTYFHHQINNKNGDNQEFNNYSISSNNHHYQDNINAYDPNEMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZA5</accession>
    <name>A0A922HZA5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_006809</name>
        <name evidence="12" type="ORF">HUG17_1360</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZA5"/>
    <dbReference type="OrthoDB" id="387093at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000130">
        <property type="entry name" value="Cysteine proteinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324692" evidence="9">
        <location>
            <begin position="21"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="11">
        <location>
            <begin position="50"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="10">
        <location>
            <begin position="137"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7645822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9516045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="357" mass="40724" checksum="6146B6259630FA80" modified="2023-02-22" version="1">MLHIILTSLFLLSLSSNIFCNTNEDIEEINHLFLDPSHLFPLLKNEVILFEEFIRKHNKPYRNDLAEKAKRFKIFRQNLLKIRMLNQNELGSAVYGITPATDMTYEEFKHHLGLRPDLYTPNEEQPEIDDYYFHDNAPDSFDWRQKLGVVSSVKNQEQCGSCWAFSATGNIEGVWALKRNESVSLSEQELVDCDTLDNGCGGGLPTNAFKTVIQLGGIESETDYPYDAENEKCHFKKSLSHVKIDSYVELPKNETYIKNYLYHNGPISIGINANAMQFYFGGISHPPNWLCNPSSLDHGVLIVGYGTGKTRILHKIQPYWIIKNSWGRTWGEKGYYRVYRGSDTCGVSQMASSAVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZT9</accession>
    <name>A0A922HZT9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pseudouridine-5'-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">HDHD1_4</name>
        <name evidence="1" type="ORF">DERF_008206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZT9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="258" mass="29153" checksum="A6E77F9F50EBE1DD" modified="2023-02-22" version="1">MIISQQKNIIVQLFETMRPVTHVIFDLDGTLIDSEKHLFRSTNDVLNEFGKSFDWDIRSKTLGLHLQKSAPIIIEHFHLPIEPAEYIGKVLSRFKSYVQGEIDGCGVQLLPGVKRLVTHLAKHDIPMAVCTGCMEDTFRYKTEPFTDFFRPGNMFHHFVIAGSDPDVGERNKPHPTPYLVCIERFENGHSLQPQQVLAFEDSPTGLRSAIAAGCQTVFIPDPKLDRNSLSSVQPSIILNSMEQFRPEQFGLAAFDTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZX9</accession>
    <name>A0A922HZX9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor SF3b 155 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Spliceosome-associated protein 155</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SF3B1_2</name>
        <name evidence="14" type="ORF">DERF_007222</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZX9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000303">
        <property type="entry name" value="splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000088">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="repeat" description="HEAT" evidence="12">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="13">
        <location>
            <begin position="589"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9516487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="852" mass="97306" checksum="030FE06A30822A39" modified="2023-02-22" version="1">MKLLLKIKNGTPPMRKSALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAAGLATMISTMRPDIENVDEYVRNTTARAFAVVASALGIPSLLPFLKAVCRSKKSWQARHTGIKIVQQIAILMGCAILPHLRNLVEIIEHGLVDEQQKVRTITALALAALAEAATPYGIESFDSVLKPLWKGIRTHRGKGLAAFLKAIGYLIPLMDAEYANDYTREVMFILIREFQSPDEEMKKIVLKVVKQCCGTDGVEPKYIKEEVLPHFFRHFWNHRMALDKRNYRQLVDTTVEIANKVEAAEIITRIVDDLKDENEAYRKMVMETIEKIMSNLGASQIDSRLEEQLIDGILYSFQEQTTEDMVMLNGFGTVVNTLGKRVKPYLPQICGTILWRLNNKSAKVRQQAADLISKIAVVMKVCQEEKLMSHMGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMEKMTPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRAAVNTFGYIAKAIGPHDVLATLLNNLRVQERQNRVCTTVAIAIVAETCSPFTVLPALMNEYRVPELNVQNGVLKSFSFLFEYIGEMAKDYIYAVTPLLEDALMDRDLVHRQTACSVVQHMALGVYGFGCEDALTHVLNYVWPNIFETSPHLVQAFMGSIEGLRVAIGPNKMLQYTLQGLFHPARKVRDVYWKVYNTLYIGAQDSLIAGYPRIPNDSTNNYIRYELIILYNHIIIIIIHKLDLIITYNHHHHKHHLRYFFIYKKNFFAMKLLFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I023</accession>
    <name>A0A922I023_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I023"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="318" mass="35044" checksum="55F42FEE496DFE23" modified="2023-02-22" version="1">MSRNFGLTRTAKLRRPGLRFGQIKWLNGLIIFGSCSFSIRLLAPLIIIIGFIIRGGSWVSSDVEAIFSSNLCKLSGLVKSMATFPFDSFRESTIFIPSLTGTILVVKTCRVVSESSFPGMDTIVRWIGSVALLSILSNSIMSISLSSRTSLFRFIDSAKRFRRIRTSLYMASAMDRDFKTSRLCSVLRLPAKPLTILYVVLMNFASASVVYFGRSQDCRLELVLALLILQMGSVIISSTLGSVRCVRVICGRRDGGGFFDVWSRILSSSLSESSKIVIGMVSSIIEATSFVSMLSSVEFGFKIFFCLPAVAMSRLGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I088</accession>
    <name>A0A922I088_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Kinesin-like protein kif21b, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">KIF21B_1</name>
        <name evidence="16" type="ORF">DERF_008384</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01372">
        <property type="entry name" value="KISc_KIF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000011">
        <property type="entry name" value="Kinesin family member 21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056532">
        <property type="entry name" value="KIF21A/B_hel_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF28">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23203">
        <property type="entry name" value="KIF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25764">
        <property type="entry name" value="KIF21A_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="6"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="1351"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="1434"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="361"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="577"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="85"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9517746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1477" mass="168555" checksum="F86C36472A64217A" modified="2023-02-22" version="1">MASNTNVSVAVRIRPKLQREEIDMYNICTRCTPGEPQVWLGDDKAFTFDHVFDMSSKQSEIYDACVTSLIEGCFNGYNATILAYGQTGSGKTYTMGTGFDVTFPQEQRGIIPRAVEHLFENINKRRDQAKNDGLPMPEFSISTQFIEIYNDEIIDLLAENRNKRNRIRIMDDEGIVLLGVESKSVSTSDDTMHCLKSGSLFRTTGATLMNAESSRSHAIFTLFIKQTRIDLIKKEDDNETPEQEVITLTAKFNFVDLAGSERLSRTGAVGERAREGISINTGLLHLGNVISALGDRTRKMTHIPYRDSKLTRVLQDSLGGNSVTLMIACISPCDRDFVETLNTLRYANRAKNIKNKVTANQDSQTQLINELRRQIMQLQLENQELRQGKLFVKNDGEVELNDVYHENEMLRRELNNANVRIKALNTRLTDVNDENINLKENLVKYQIANNDGGGGGGGGGTSITNQNANEDAAESFIKAYLKEISDLRSRVVESEHLITHYRKQLNRTTNDEYETNGGMDIIEKAKHDVELGKSFYNQLNHSMSSPDSNGNRVTDLHDDDQEDFSEEDNTEDFETKLANHNVELANLMESLASKERLIEEFEARERRIIELTEQYEQKIVSFKMKIKQIEEDRDKLMGKIKKENKDDHTSKAKKEEYEKRISNLQADIRKYENLKREHKKMLSQESISKEQLKKLRQEVLEAKQHRVKLIAQMREQMGKHNKELLRNRIMINKLTREDQKKDMQIRNLETRSNQQKKILQRREEEIKNLKRLARPAYSDRVGGRLRRYMNGGSTPQKARDKWTQFEQKFNKIVALRTQFELEEKKLTRYYEDRQESIDLLNTLKENNDDYDYFESVKENIEYLDQCIKTSQGIIMQSEDENLNIDQLFDKLDPDETEYILNKLANSAINHAIVASQRDEELKEKDARCKNLTDEYVARSQLLDYLIETNKLQQLKYENDNYDDDILPHISDIPPSNPKYRRLTRTPAELLLPPQSQQEQEIKHQQLEMNRTFWLIKDNDKNNIDQQQQHCDSNSLMIQSMYESSNAANTVSSAGGVNPNKSSLNGGGGGGAASAVPVVCHVSNASSLNDTFNINESSTAVTGTPPGSPSINRRINRETTKSSTLMCSSMNNDSDVFSRLTGASTVSNQVENSIGQILPCTTASSSKAIDKQFPLTCTHSLDIDEHGSKDCTAKIWDLNQCTEVFSLNDHPDAVNVVRYEEYNKLIFTCSKSIIKIWDPRQKPINCVRTLSSTGLTTDLGNDIFIYDIQLSADGSILFSTSDRIVRAWDLRKFQPISRLNTGHNSLVTCLAVDDDEINDTRLVITGSKDHYVKVFELEQNLNGIYVPKYTLQPPHYDGIQALRLINKGRFLFSGGRDGYIKKWDLTAQSCMATYSNRGWVLALDTFLQETVLLSACRSGYLRLWSTENCHLFGEIQAHQMAVNDIATIQQTIFTASNDCTINLWQHRDSSPIEDIISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0A8</accession>
    <name>A0A922I0A8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_007851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0A8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="111" mass="12469" checksum="F0B2281C1D82EEE4" modified="2023-02-22" version="1">MRIIIKFLSFGLKSTNQPTRIPFLTNDDDVLLRTNGKNCLFKKKKERISNWIRTLAKNGLGLFVCSITLVTNVIITGVNHVRLTSPSSSSSSSEFGTKFDPNSYNRYVVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0U0</accession>
    <name>A0A922I0U0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CCDC28A</name>
        <name evidence="2" type="ORF">DERF_010216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0U0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025271">
        <property type="entry name" value="CCDC28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13400">
        <property type="entry name" value="CHEMOKINE C-C MOTIF RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13400:SF4">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 28A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13270">
        <property type="entry name" value="CCDC28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="289" mass="32695" checksum="02BB620BE4C5D46E" modified="2023-02-22" version="1">MSSKKKMMMMTSFSDDYIDILAAETNQRSHIQQQPQRRSQSQVQPPYSSSPKNQQHHRRNIHRAQIARHSHFPSYYTLNSLYSKPNFLREFADVRETEQGLTDLLNDFHDGKINAFGENITLENMIKVREQQENLARLHFEMNSQQSNKQSTIDVSGMCNTNASLYQSGGSQPSTPSSSLDQKEQSYQSDSQLSNEPMTMVFANMNGQTTTSSDNNNNNNNNGNSSPRIIISMEETSTTSSSPQPQTPDPMVICGKPFSKSNMIKLIQNLQNLCESIELLQSKNHSAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I153</accession>
    <name>A0A922I153_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">3-dehydrosphinganine reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KSR1</name>
        <name evidence="14" type="ORF">DERF_007457</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I153"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20812">
        <property type="entry name" value="C1_KSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000107">
        <property type="entry name" value="kinase suppressor of Ras 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000034">
        <property type="entry name" value="Kinase suppressor of Ras 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF253">
        <property type="entry name" value="KINASE SUPPRESSOR OF RAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="13">
        <location>
            <begin position="591"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="914"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="471"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="718"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="845"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1190"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="523"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="747"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="845"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="940"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9516737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1209" mass="136841" checksum="D33F963E246AD77D" modified="2023-02-22" version="1">MHPDSDYVHSVEQCSSISTISANWLQTIQWNREECLLWKNLIEHDSNQLEKLCSYNEFDEIIKQQIRFLENKLVRNFVKLIFARRHWSKWDEIDDLHSFSIVSNWFQAIGLDHKCKEVILLDHYEDIEELLNADEEELKILLMRGFQLRLDELDFDDDICNNDEDFKDSYGFYNQHDRNGSITDDDNEDNDHEKSTIKQDLRMYIHDYIIRVWKAHRSMHRCLDTIKNFDELPSTILDLYWDSWDHWIQRADESQKASLASAIAMLKKAKHSPKPLPPLPDLKANFLRNYRINGDSRSTGSSPLSPPVPPLSAGNFSHRSTSSSSSSIIQSGFHNLNLIIDPNHVPYSNSSSQQSSGNLQHRRPTPPPTPPVSHHQTKKSFILLSSATLFNNAASNSRNSSERKFPTTPPPIRRHQTNIFGIGENFPLTKSKSHEEHLSNRIELLDPVINSKLLKKYNLVSICGKSQKPCHQHNYHHHQSSNNKHNSLDNLPHVPTSTNMASQTPFPHHSQRRRLATEPGSIGSISPILTSSNCSSPIAISPENQTYHDNSNSNNITNNNNNRQSAAVDNCFLDSTVPRSPRSQAMSHSIHHRFVSTMKINSIQCNVCEKQMFFGFKCRDCKYYCHRDCQDKAPNSCGLPNELVDIFKQTLSEHNVGGHQTRSSSPKNQHQQSMIPQRAKSQMSNYYCGSQMNLIGGGSHSSSSNPSSPAAVFLHHNQQHQHQLYNSNAQSSSSSSTTISPTGPIYYSNQKTPGSACSGSQFQFPPDINITSTMSVDYDDSLMVTEQFSPTLMSTEMEIENTPSNFISTIQEEEEAATTGAISRASTASPTITLTSQCSTLPQHSTLIDSDKSNNSALITSGSSGDSIRTVTGRLDSQDSQASDVDQNDRGSATPWPRQNSVTSCEWDIPYDELIIEEEIGTGRSGTVFRGKWHGTVAIKRLNMGQTNVSEEKKAFETFKQEVAIFRKTRHDNLVLFMGACMKPPHLAIVTSFCKGLTLHTHIHVRHDKFNLNRTTMIAEQICLAMGYLHARGIIHKDLKTKNIFYENGRVIITDFGLSSVAKLCMSNRRGDRLTVPKGWLCYLAPELIRTLSVYSQDGGDDLPFSFSTDIYAFGTVWFELLFGSWPFSGQPPEVIIFQVGKGIKHPITNFQASKEIKDLLYTCWTFNPDSRPDFSKLYEYIEKLPKKRLQRSPSHPAHLQHASEQTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1K7</accession>
    <name>A0A922I1K7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Rab5 GDP/GTP exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RABGEF1</name>
        <name evidence="8" type="ORF">DERF_008035</name>
        <name evidence="7" type="ORF">HUG17_2309</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1K7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF122">
        <property type="entry name" value="RABAPTIN-5-ASSOCIATED EXCHANGE FACTOR FOR RAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="5">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="VPS9" evidence="6">
        <location>
            <begin position="351"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="661"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="666"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7646771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9517357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="714" mass="81666" checksum="623AD2E7491E0CF9" modified="2023-02-22" version="1">MDDDFGITTTTTASSIDESDDSIIVLKNNKNNNDNDGDDNHDTSMMTMNNDNGGSYRHKMTVQIVADKSALHCKNGCGFYGNREWFGYCSICYKEIRHHQQQQQHQHHHNQSNMAQIQKNYPVSSSIPPPSTSMSPPPLQPTSQSSSFSMSLKQKILPESLNRAHSTTSLSSSTASFLTNPTGSLSFRKFEEKKRQQSEKNRIKSIFKRASTFREYRSSSAASSSQQHSNSNNNSQHTTQENNSWPFFSLERPFEEVLAKFYPDYALRDINVNVAKCVEKVNKLLNRGTSIEDLTELMHDFYSTMENRFQTSPHYKDVNSVQFSQLIDQTEKILMNKLYTNLFARVQNEEEERDLELQKKIRNLNWIMSNHLDIEINLRHPKVKDLMDQAITEISEVDSKQIPYEKLDAIVRCSKTIFEMLQIDNNAAISADQFLPALVFVIINANPPLLQSNIKFITRFSTPSRLMTGEAGYYFTNLCCATTFIEKISGESLNMSESDFQSYINGEAQPPGYYKQSFLCEPFRIMNSNHTILNDTIKRNAQWLENLDYLEKRMDRFEQIFENKCRVAIDSSKEMIAQHSTYKIFDTASVDDVDPLLFPENFRETYKKHRQQKKEKENLLIEIESTSSSPNLNINDVSVDSQIVCDQLASIDFNHDSSIEPLTVETNDDDKDNNNDNDDDGGGFPKLPNPLCPEPISTTTTVNSNSDQSEKTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1P4</accession>
    <name>A0A922I1P4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Transcriptional repressor NF-X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NFX1</name>
        <name evidence="13" type="ORF">DERF_006600</name>
        <name evidence="12" type="ORF">HUG17_1214</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1P4"/>
    <dbReference type="OrthoDB" id="6512771at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF12">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR NF-X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="885"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7645676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9515825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1000" mass="115839" checksum="76CD05D0482042BE" modified="2023-02-22" version="1">MAHPEKTSDNYRYNNNNGIDQSQNSRNMNPFHRQQYNQNNNTDRYNYHRGPQNSRFNNNFNHFRDQDNYDSRRSGNYSYRSGKQSNHQSNELPPRFARNRQMNSNENHSRNNYQTRYRNNDPQQRIPYDESDMYNRFSRMDMNYGSNEINRDDRYKTFRDDDGLRNVPSTSHHRSQDFHQRHHYQAPRNRMLIDNHNGKHSTRSMDNNKTDKSPVKSDLESQREIMDELLRKAQYECIICCEMIRVHDRTWNCNNCFNVFHLKCTQQWARKSSVDPNEASTSQDNKKKNQQIQEWRCPTCQTVHRNFPHHYYCFCGEMKDPETSNYRVPHSCGETCSKNLELFNIKIENEEYFECKHRCTLMCHPGKCPPCTLKVERICACRKTKMSLNCAAKLSDIKCLELCNKLLDCGKHRCQKNCHFGQCNPCEKIFEMKCFCGKKSREAVSCIDLESGFSCEQTCSKPYECGSHKCEKQCHSGSCGSCPLSPELVTKCPCGKTILSSIANQQARKSCLDPISNCGKICDKILSCGSDNIDKPHQCKSFCHSGSCPPCDQTTIIRCNCGANSQKLNCSELESKTFKCKRKCNKKLSCGRHKCLKECCTEKEHFCRQTCGRKLVCGKHTCEEQCHQVCRSCPNVIWDEITCNCGHEKLFPPLPCGTLKPPCKRPCSRKHGCDHLPLHPCHDEPECPPCIEFVSRLCYGGHEVRESVHCYETGVSCGRFCQKPLPCGLHKCSKICHNGDCPVCTQKCIKIRLNCSHQCGLPCHQSSSVTCPESPCREKIRIYCECEFKSKEVECDTVLDSRRFQQHLDDILRRFSFNSSITLDEMKEMVRHNVRHSLECDQDCAREKRNRNLADAFGVDSEGLTIGANLVKYSDQLKNEARSNPQFIMTVHDKFVQLIDAFKQSNQKIMCYNFQPMNRNLREIIHNYAAHFGLKTESVDKEPNRSIIITANKNSAIPKTTLLEAVNIDVKDLRPKQSIVKYKKASEENRNKKVINYFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1U2</accession>
    <name>A0A922I1U2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_008903</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1U2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9518313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="331" mass="37585" checksum="5395F6FE196F963B" modified="2023-02-22" version="1">MRSDVKVSVDEAANTIRNRILPQLGVLISNCSNFQAKENEYRKKIDDLENELKLRETEAPRLAKIEELVKQNSQMLSQINKHESNTYHNSYSKVASSSVAHNQYQPPRNSHASVLYIKNDKQNTTAAEALKMARVIVSSNPAGTAVVANKLLSNGKILVFSKNQESKEKLDQVINSSKDMVAEEPKRFDPLILIKGVPKDILGDMEDRERASNLIPKLIKECNQDITNACENEESIAVVFFRKNRKDHLVNVGIKVSPRIRKVILETQDGKISFGFNLVHAEDVSPLKQCFHCLGFGHTKKNCPKKEEMPQCKHCPNKHPYQHIEESTYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2I9</accession>
    <name>A0A922I2I9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit Tim17-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TIMM17B</name>
        <name evidence="14" type="ORF">DERF_008530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2I9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="143"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9517912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="183" mass="19450" checksum="890907C8C4F12975" modified="2023-02-22" version="1">MEEYSREPCPWRIVDDCGGAFTMGAIGGGVFQAIKGFRNAPSGFSRRTTGAWSTVRSRAPVIGGNFAVWGGLFSTIDCSLIYLRKKEDPWNSITSGALTGAILSVRNGTGAMIGSAIIGGVLLALIEGMGILFMRYTSEQFRPQNPLEDPTQLGSPIPSSSSSSPSSLSDQMASPFATQPQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I409</accession>
    <name>A0A922I409_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="8">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="8">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="8">HAD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_008813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="8"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I409"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Domain A (catalytic)" evidence="8">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Domain B" evidence="8">
        <location>
            <begin position="199"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9518222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="300" mass="34969" checksum="5DD9E6F2EE043B36" modified="2023-02-22" version="1">MMDQSVIPEAKLIDVHSWLEENESNFKPPICNKMMHNDQLKVFFVGGPNERNDYHIELGEEFFYQLKGDMCLKVIECGRKKSIHIRQGEAFLLPARIPHSPQRKANTIGMVIERQRENNELDGLRYYVDDDGENILYERWFHCYDLGTQLAPLIKKFHDSNEYKTGKPSENSRLIEVPYMDDNRTVNIDPISLSKWLQCHDEEIDQIGHRTLFDESYGFTTRVQIYGGDFKHCIRSDKKDDRFEIFLWQMVSSATIRLGQQPIIHLKTGNSLRIPPFTRVELDTRSGCYTLVLSMPSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4V8</accession>
    <name>A0A922I4V8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_008076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4V8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF6">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="363"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9517400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="518" mass="56151" checksum="67F4AAB405EAE0A5" modified="2023-02-22" version="1">MNGINTASNNNNGYESSSSNNNTKNDTNIDFANNNSATTAGGDSANALTSATTTTATTSNNNPTSSSGSNNNDNSSNNNNNNNNQQDDVCRDYLRNVCRRGKSCRYKHPDVNDSEMMKNKDPYVFCHDFQNRECRRDNCRFLHCTKQEEEIYRNTGKLPPHIQAQYPPDERNIAPVCKDFLNNTCRRGPRCKYRHPLPMNDSFHQYGHHHHQQQPLHHSSSPSNPVARIGNQFNGRGGGGNYPNSHMADYPTHYSRAGSNSGTMMPSNYGSYDAYADTTPQNKRKRYDPQSSMYHHENNGPYSGAYQEPPPPPPPPPSGNVRNTYGGGNSMHDTPYGASGGAGGYPNSQPPRSQQPPTIDSSRSYLEEENAALRRRIDDLKKQVQDLLSTNEYLMEQMNQIRASGQAAVAAACGAPHGSTSVASLQPQPTPGSVQSTAPIGMSAPITLQAPAQAAVAIGPLPPVSIVSSIASISLPTVSAPVTLVPNSSAAAYTPSMATMHSSNPWPLGVDQLLKNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I603</accession>
    <name>A0A922I603_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I603"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="69" mass="7907" checksum="26D6A0F48314E424" modified="2023-02-22" version="1">MKNFQKNGTRAICHIVNQCLAVHLCRFQFHSHSHIQISNIINPEHLLIVVIVQLTHGSCICICQNPYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6G4</accession>
    <name>A0A922I6G4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_000382</name>
        <name evidence="3" type="ORF">HUG17_8196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6G4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="589"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7640727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9526282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="630" mass="74769" checksum="CE994341E9D4A925" modified="2023-02-22" version="1">MPSNRLQIEGILSTAFDDITDIRQTSDYDDNNTFFISKLNYKQNSFDKKPSSSILNNESNVHVNTSTPLINRNQQTMVNGLLNRYNYRNNFKDIVEEEECTIQDVESLDNDDGGSHSDNLSLSTDHNFNNNHDDDEENILQQSPKFLLHNNQDLSLNDVHIKDLCMLKQEFAQINTNYRLLQAKYHKLYQLNEENAGLINSQCVKIQKLEKQLKEERDGRESERRLASMFESKVSSLEYQLNELQKGDNRNLNSDEQMKWFETLKIRHHKEMNNIRTDYETRIEKLTKTIQAKDDELIENCNILLKYKQEANYFQEKLKKLETDFKSKLQQEIQSAKERTESNMLKEFDDSMRKLKSEWEHKLQEDIDKIVNFFENNDDEENNLIESSSPKFDVRFEKLIDLYRSLKSFSINREQHIQTQIDRMDDAKRQLEKAIIESRMRNSSISSTSSRSDLIEMDNNNGHMMDIPVHSKSSPSLVTNNKKKPLPALLDLKEFNENNVMLPEEKAKIMTNLRLKYEKEMKDIRDQFESELDLLRIQLLNKEEETVQYRVKTNKYRQHIHSLKDRHDQDLNLLKNKFAKIIQELMDDKKQHQNHHHHHHRHHTHFEDLPEKPIRKSNSNGHGPFNFDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6G9</accession>
    <name>A0A922I6G9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_000022</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6G9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF5">
        <property type="entry name" value="VENT HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="203"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="205"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9525889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="506" mass="56179" checksum="F99396873EEDEDBB" modified="2023-02-22" version="1">MPILSLNHTDDDYVNGLMINKSTSSYSQSKAMISSSSSSSTSSAIIDPEINFITNQNKIEGGGVCIPSTIDGSCYKNFPLCLPITITPSSSSSLTNHAELPNINDNNNNNNHNNSKHSRSMDKKFQFFAAAAAAAAAAAAAAATTANQMRSNELNVNIKGQHNQHHHHHQMIPTNNNHNGQTLELQSTAAATPTTTTTTTSTKKQRRRRTAFTQAQLNFLEKNFHEKKYLTVADRGQVADALNLSETQIKTWYQNRRTKWKRQHNVKLDELRYNGPKNSINSKNHCEDSTKIIIKNNNNDTVTDQQKQQTNESILLDPVNSYQANFKIPILQANNRHSPLQSHSPSITSSPSSSSSASEQQQQSTSTLSSLTPSYLQPFVSSSSSNNNYNHSTVNNLLEKMISKNFLINSLMHHSLQSLSPKTIPINLPHHNQQQQQMYGQTNFMIDHHHSPPPLPPPLPPPIMMVKSSKKKNSTFHHHMEFPLPSSSSSSSSSSLQQRLRNSNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I739</accession>
    <name>A0A922I739_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I739"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7645" checksum="81F90239230EB53F" modified="2023-02-22" version="1">MDLWPILIFSFEPLKLHEYLLHSFLWDIIFLNATMNIYNNNNNNEMNERRQTTYNEERHGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7S4</accession>
    <name>A0A922I7S4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fatty-acid amide hydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FAAH2_1</name>
        <name evidence="5" type="ORF">DERF_000023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7S4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052739">
        <property type="entry name" value="FAAH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372:SF3">
        <property type="entry name" value="AT07710P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43372">
        <property type="entry name" value="FATTY-ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="64"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9525890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="538" mass="60005" checksum="79B7FC76FCAEB6E5" modified="2023-02-22" version="1">MFMLIIDLLLRQLRYIVNIFAIIIGYIFYPSQQGFLPTIKNDLLLQPAIKLAQKIKSGQLKSEDLVQAYIDRCKKVNDDLNTIVHDNFTDALQEARNVDERVQRELRGEKLPDESSIHDYPFLGIPYTAKNSISVKGFTFTCGTYNRKGIVADKDCTTIINMRKSGAIFLALTNVPDTTLFSDSFNYLDGQTNNPYDKSRVPGGSSGGEAALIASAGSVLGIGSDIGGSLRIPAHFCGIFSHCTTAGNIVIDEIFPPQKDIHPDVLTIGPMCRYACDLRPMLKVMTGDKLDLTEKPFNYSDLNVYYIRDLGDPLALPVDVEILKGLDKMVRHFIENGTRTMELNMAKGDPDSFYDFRLATLFWLAALHDPQMPSYHELISYGVKMNPYYELIKCFIGTQSRYAAGPLVIGITQKVGDKFLTKDFFDKWRKTQSNLHKLLENDGVILCPISPEIAPKHNQSLLKVFDCVYTMLWNSMNVAITTIPMGIDRHGMPFAIQVIAAPNNDKLSLSIVEELSKHFGGWIPPCPVDVLSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7X8</accession>
    <name>A0A922I7X8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7X8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9525962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="92" mass="10545" checksum="1070396CD6EA71DF" modified="2023-02-22" version="1">MYVHVNDHNETGGKKAKEILINIFDPNGMNFFLFHLRAFFEKFAEYLPKAKPSLNRPPPPPPPNTYRPSSSSLEFNYTLKCNVVNGKFGDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7Y2</accession>
    <name>A0A922I7Y2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">protein-lysine 6-oxidase</fullName>
            <ecNumber evidence="12">1.4.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOXL4</name>
        <name evidence="17" type="ORF">DERF_001095</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24544"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:12448"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:131803"/>
            <dbReference type="EC" id="1.4.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>lysine tyrosylquinone residue</name>
            <dbReference type="ChEBI" id="CHEBI:20489"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lysyl oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.13" evidence="12"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7Y2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004720">
        <property type="term" value="F:protein-lysine 6-oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000026">
        <property type="entry name" value="Tequila, isoform D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050912">
        <property type="entry name" value="LOX-like_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001695">
        <property type="entry name" value="Lysyl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019828">
        <property type="entry name" value="Lysyl_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817">
        <property type="entry name" value="LYSYL OXIDASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817:SF4">
        <property type="entry name" value="LYSYL OXIDASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01186">
        <property type="entry name" value="Lysyl_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00074">
        <property type="entry name" value="LYSYLOXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00926">
        <property type="entry name" value="LYSYL_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0886">LTQ</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037633339" description="protein-lysine 6-oxidase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="16">
        <location>
            <begin position="37"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9527047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="383" mass="44122" checksum="942C0F07E6A41A2F" modified="2023-02-22" version="1">MINFILFFQLSILMTINSQLFNDNRIDNNNHHDEGMIRLVGGRTMFEGNVEINHFGQWGMICDDEWNMNDANVACKQLGFVLGAIMATNNSRYGQENELIWMDNVMCDGRESSISSCRFNGWNIHDCKTDEAAGVICRVRFDQPQQPLWPIPIPKPTLMVNRQMKMPDLPDLEPDPKEVEKSAYIESRSIMYLQCAMEENCLSQSAYEIDKNDPTWIFHTRILLRFTASIRNVGNVDFRPFRQKNQWIWHSCHRHYHSMEIFATFNIIDHDGNPVAQGHKASFCLEDNECHNGVDANYVCANYGDQGISVNCVDIYKSDLDCQWIDITDIVPGSYQLKIIINPEMKVAEKTFDNNAVLCSFDYHDGHRNHRSIVVTNCTLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7Z7</accession>
    <name>A0A922I7Z7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_000112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC34A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7Z7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01013">
        <property type="entry name" value="2a58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="780"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Helitron helicase-like" evidence="9">
        <location>
            <begin position="163"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="931"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9525992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1071" mass="120782" checksum="F2F2703C7C25BFED" modified="2023-02-22" version="1">MSVYSTVPNSKIFFKQITDSNSSDHQHNFFNNNFNNGFMINLNQINGNSTMISTSNNHAVANDSSSLNREEFHIALTPPNTPTHGVIINTTGPPDDEPLQTEADDDDPFGQPRAFILINNSDSTQSTPSDLRSLCDTPDSQEPWNLPQLSQSSGPKWNDSCYKNEVESRFGRVVILASSFEGSARNINEHYHDAMAIVAKYGFSELFITMTANTEWREIIENLHPNQTAFERPDLIDRVFKKKLNHLMEIIYKKAYFGRCQAYVYTIEYQKRGLYCWLIDADKLDIAENIDRYISAQIPPNNPDYEFVREIVLKHMIHTCMPNRCLEEDGEYNKKFPKPFEAETVIENDELDYKRKLVHITIIVLKLIAILLLLYSFICSLELLSTSFRLLGARVIGNFFQDNELLQNPIVGLMIGVLVTVLVQSSSTSTSIAVTMVASRIIHVRQAIPIMMGANIGTSVTNTIVSLMQSADRDEFGRAFAAATVHDMFNWLTVMVLLPIEMTTHYLERLTTFMVEKFSGELQQDKMANHQFLNHLTKPLTSRIIQIDKDLLEEMAYGNHSALDPNRHLLIRCCSSKESSMLPEIFADTPTGLILLAISILVLCLCLMLLVKVLNSMLTGQIAKLIKRTMNRTYAFPYSLIADYSAILAGCILTILVQSSSIFTSALTPLAGIGIISLEKIYPLTLGANIGTTTTGILAALAADPNRLHDTMQIALCHLFFNISGILLFYPIPCMRIPIPLSRMLGHITAKYRWFSIFYLLMMFFMLPLIVFSLSTLGSFAMLIIGIPFLLLVMIIVAINLIQHHLPHWLPSWLKNWRFLPLWMRSLDPLDRLITRLSKQFGCANCCATSGQLQHMRFERGHDGTKLLGHHSDTHHSRLHILGAMYRSNSEQHLSDSLLIEQHRHHRHHQTYDRPSVPETIKRVISKLAKASQINSSHQNISSSGGGGVGNNINRRHRYSNGWQQPSTTTTTTTDDSHPNWSLFNSHTVHAGSQVHRYHYPSSPFSRASTQMEYITRRNIDHSTDQTIIPLPSSSPLSSSIPLESTTTTTTSSLLSPNNDPLATVDETKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I943</accession>
    <name>A0A922I943_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase family oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_000009</name>
        <name evidence="4" type="ORF">HUG17_7913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I943"/>
    <dbReference type="OrthoDB" id="6877434at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7640446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9525876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="239" mass="25862" checksum="7E3B5CBFA13A10D3" modified="2023-02-22" version="1">MTFKNVIVTGANRGIGLEFVRQLLKQNNSPKNLIATTRKQSPELDSLKSAHNNLHVLTYDATNYDSYGDFVKQVESIVKNEGLNLLINNAGMAIRSTLDNVTPKDILTNVEVNAVGSLMLTKALLPLLKASAAAGQKTLVANISSAMGSIDDNGSGGSYAYRASKVTMNMFTKSLSVDLKSDNIIVMTLHPGWVQTDMGGPNALINTETSATGLLDVFNKADMSYTGKFLDWAGKERKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I978</accession>
    <name>A0A922I978_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">STT3A</name>
        <name evidence="24" type="ORF">DERF_000066</name>
        <name evidence="23" type="ORF">HUG17_7955</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">JKM2019</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the oligosaccharyltransferase (OST) complex. There are 2 OST complexes, OST-A and OST-B, which contain STT3A or STT3B as catalytic subunit, respectively. OST-A and OST-B contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, and OST-A contains DC2/OSTC and KRTCAP2/KCP2 specific accessory subunits. OST-A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the OST-A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The OST-A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I978"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000002">
        <property type="entry name" value="dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054479">
        <property type="entry name" value="AglB-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF43">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22627">
        <property type="entry name" value="AglB_core-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="21">
        <location>
            <begin position="38"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="AglB-like core" evidence="22">
        <location>
            <begin position="543"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF22627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH7640488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAH9525936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="731" mass="83233" checksum="75A273E5A97A2403" modified="2023-02-22" version="1">MAGHSFLNVKKDSQTMAKNDTTIFGNNNNSSSSTVSLMKIVILVISALLAFFVRLFSVLRFESVIHEFDPYFNYRTTRYLAENGFYNFHNWFDDRAWYPLGRIIGGTIYPGLMVTSAVLFNLLKMLSFPVDIKDVCVFLAPLFSSLTTIITYALTKELSDEASGLVAAAMISIVPGYISRSVAGSYDNEGIAIFCMLFTYYMWIKAVKTGSIFWSCLCSLAYFYMVSSWGGYVFLINLIPLHVFTLIITGRFTKRVYVAYSTMYCIGTLLSMQIPFVGFQPVQSSEHMAAFGVFGLCQLYAFNSFIRSKLSQEYYSILFRSLVLFIGIISLSAIIILTIIGKISPWTGRFYSLLDPSYAKNNIPIIASVSEHQPTSWSSFYFDLQILVFLFPVGLYFCFKNLTDYNIFIILYGVTSIYFAGVMVRLMLVLAPVMCILSGIGISRLLTIYCGHLDSTTGQSSSSTTHHQSERKQKRIENTFVMKKEVATVFVFIATGMLLSYGYHCIWVTSEAYSSPSIVLSARTHDGSRIIFDDFREAYYWLRMNTPEDAKIMSWWDYGYQITAMANRTILVDNNTWNNTHISRVGQAMASDEQHAYKIMQELDVDYVLIIFGGLTGYSSDDINKFLWMVRIGGSTDRGRHIKEQDYYTTSGEFRVDKEGSKTLLNCLMYKMSYYRFGSVYTEGGKPPGYDRVRGTEIGNKDFELTTLEEAYTTEHWLVRIYKVKKMPNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9D0</accession>
    <name>A0A922I9D0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AarF domain-containing protein kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ADCK1</name>
        <name evidence="3" type="ORF">DERF_001376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9D0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="115"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="522" mass="60927" checksum="EAFE1A56B00A29C4" modified="2023-02-22" version="1">MSRFLKFSTFAGIGGYTGYVLHQNDWNPRHIGLVRFGVAAYTVSQIAIDYKFSVSKLRDDSMETLEKWSQCHQRSADRLLKLCCTNGGVFIKVGQHIAALDYLVPKEYVNTLKILHSQAPRSKFSDIKKVIEKELGQQIDEIFDEFDEKAIASASLAQVYRAKLRNSNETVAVKVQHPKVFQHSLVDIATMEFLFNVIDRLFPDFSFMWLVNETKRNIPLELDFVNEAKNSEKIAILLKDLPWLKIPHIYWKHTTKRVLMMEFVEGTSITDKEFFISNRMNCQEIANRFENMYGRMIYTYGTVHCDPHPGNVLVKKTGSKDFYLYLLDHGLYTQLTDEFRQNYSAFWLAIFRGDLKQIQERAILMGIDEKDAPLLSCMVTAKPWSAISRGLENRPKDQTVISKEKNELRKNASLYMHNISQILGKVDRQLLLIMKTNDLIRNISHVLGCDERRSLLNMNRYCIQTTSEQRLAQSRNMFQRIIIRLQTRYLYFKLSLYSFYLWMDSWFTYRSSSIKSTLSAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9K1</accession>
    <name>A0A922I9K1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000772</name>
        <name evidence="1" type="ORF">HUG17_8512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7641043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9K1"/>
    <dbReference type="OrthoDB" id="10354901at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7641043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="146" mass="17240" checksum="ACA8ADCC4DF73784" modified="2023-02-22" version="1">MNLFIRINKIWPSFHICLFILIWTIWSFISIHDTAATAASTTIINTSSSLVNCRCGLKPWKNRDTDSEEPTRDCCQYFIQSRQGNFSDTTFLCHIHNELVYKRFHSCCITLLHNAYCSQTRIKSGAANKISSDRQRQRRRYRYRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9W1</accession>
    <name>A0A922I9W1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL24</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CACHD1</name>
        <name evidence="10" type="ORF">DERF_001621</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18773">
        <property type="entry name" value="PDC1_HK_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF66">
        <property type="entry name" value="VWFA AND CACHE DOMAIN-CONTAINING PROTEIN CG16868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037196116" description="Large ribosomal subunit protein eL24" evidence="8">
        <location>
            <begin position="27"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1288"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="TRASH" evidence="9">
        <location>
            <begin position="1502"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1416"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1590"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1421"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1436"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1592"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1620"/>
            <end position="1640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9527614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1653" mass="190551" checksum="1BC5EAE741028FE5" modified="2023-02-22" version="1">MIHQKQRMAMAHAIVLLMLWLGIVNSINYHDHPDHGRMIKNDTKMTRLFFVNVDKIRSSTSNVTSEINRKNLYPSLVIENVSIDQMTDHFLDELNKFGAYSKLTSQLLQSIVNKELGATFMKRLLNKANRNHDQQTVDLTADIIDNMVDKMSQQVQDIHSAIEMVGELLQETYGQHSNTTTTNTFDCCNPYEDRWPEYHENNGSGYYDAKELQEIKLEEQQIRNYNYDYDKRFYSWVSKSFSCDMDYWNRYKEFHPALTEQFRRNLVANVHIKWQYYMSFNGVHIEYPAYYPPNNYCFLNRLNMKAKFFTNEFNATTNGNLKRYPNSKGKKILHQHWLNHHHHYKAYDDQRQFFAQRHQSNLMAAALPRPKMVIIVLDRGSALTDHQLRVAKSIVKHILNSLSHRDKISLVDLSSSAHDVSGDTCGSNLAMANADYESKHIYGKYIDRLQRSFNSTNHYLGLKKAFEIVEANYLSFKEMEPPVLIAYISRGLLASLADARPVMQLIADQLANANYQFIINTYALIDERIPIMLETIFLREVAAMNFRKFNVQSPAQVMIRPGIMVAINSTDQLSTVLETIYTVFKNDQHLNQTNSLYVSLPHQDLISKDTYVSLSKAYHHPQDGLIGVIGIDISLLDWAADVIHYDGHQNSYAFLMDGFTGKLIYHPVFAKYFQETCKPRQVMSKYGLYTNQASDSLENSFINAHLVELELNDALLKQMIFTTHSGEYQIDSTKYMWNKTVNDWSYEWRGCLLNPYKSLVYHWRRIQATHYIIVIVSSTTHNNKQSSIEPHGQAEWQLVSHRLDYDWQLKGHVTLCKHFNQLATMDKATVHLSPNAFIDSYQIEMNLDSSHTIQRQWSYLTDRSDLIVNPGFKPNVRPDLILVNELIDHWQRRNQEITECSKYVVRKYIAVVSGSFTVFPGSLMDLSYRPKNRPWYIRAIAEPEKIHLLPPYMDVGGSGYIVTISQAIYKTTNQSKHSENDEVWAVIGIDLTLGYFHRILDAMVSICRRDKASCFLVDQFGYIIVHSSLSNMPTLAMIERQHLTHKEPHMMNSLLSQEDRFIRKIVCNSYTDRTMQRFYRFNTSLNGIVTSVYRNEQISCAKYMIISLTTTNALFGMVDHSCDNVTTTFCPCSLTDRLCLNCHRIEQTDCECPCECPLVMNVCNGQFIESDDGRHPICTTAAVSPPYEQQLREPYGSKLHLGSYNSCIHNDCHNKLLESECKGILGCEWCIMDNGMTKLANPFCSNQMVCFGGIFGSENPYLSQQQPYLHFYRHNDKPMQQTQSTAPIGPLTATLIICFIILTFSVYCFHFQSNRNLATSRYLNSSNHNDHQMLQPNNHNDMFDDSQENGSNIESLAQAVVNANYARIASPYQYNSNYRRRMEAESDYGYSTMTPNEDSEHNIPIYINPDIIRTRKKSNMDSRSSVASIVSNEGDSSIQSSPSTLSLNNNEDMSRLPPPPPTRSKSKNRSKQIFVDTEHSRATRLSTVQERSIVIKMKIELCSFSGYKIYPGHGKRLVKIDGKVFQFMNSKCESSHLMRRNPRKTTWTVLYRRKHKKGSEVELAKKRRRKTTKYQRAIVGASLNDILAKRNMKPEVRKAQREQAVRAAKEKQRSTKGQKKSSQAGQKSGQKAKQAQKATKPVMAKAPRVGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA94</accession>
    <name>A0A922IA94_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA94"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23131" checksum="6110C29E434F3BF5" modified="2023-02-22" version="1">MAIIINHQSFDYLIILSFAFILFDDFCCLKISSIKSSPQSINANVQQQKRGPEFLIEPPGIITFINDTGTVITCSARGQPSPKIYWIYATIATENGIGGGSMMNHLIPVDGLQQIRHDSLASQLIYLPFKSNQYRQDVHSIRIRCIATNQFGSIQSHDIQIRAFNRAIRCHYTEFIRDMSCYTIGFALEMIRMCWLVGNTAGDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAW5</accession>
    <name>A0A922IAW5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_002095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAW5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9528124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1040" mass="118555" checksum="9BF99D49850F8209" modified="2023-02-22" version="1">MEHYYRFNEMSEIFFNCSINSNPDAHRIEWFMNEKLIHTDIPKGIIITNTNRTLIISPSQRRSSGLYYCAATNILGKTVSDRVQIDILFKPQCQVEFVQTYYQNLDDYVQLKCHIIANPSENVQFTWRFNDTVFIGDFNSAYTSSSSSLSSESFVEHVSNDIQDISSSSSIEDVIDQEFMMNHDKTINSSKRNNNRRWKIPRPKSTLIHTTIDHQHLITNVIRIHLKKWSSFGQFTCTAKNNVGIQSEPCRWQLIPHHYHTHYRNSYESSMNIIHGNRHHFHHHQQQQQQKSQSLMQQFSSSSSRLPNQLNNCHIIESSNAVVIKCSNGVEVYERTSDSSNQHLDSIQTMNMNDSHYRSNHYHNRHPNNNNIYEYSNGGLSNQQVRPLLTYHVQVFRLSMNNNSIIPIIKTLANDKINEKIANNNYDNDTPNNNDHYDGAIDGDDDEHFEQYSHQKSEPKKLKNPTIMNQPETKKQIASIHGGSSSHGESRTEITSTTKTTMTNKPLPIMETLNFTNPLFIITNLTSSTSYLLRIWSSKQHMDDSMIEQVNITVRTKPDDDEFDQNHHHHQQHGDRSKMDQKSVKIFDNLLSFISFGHKDLFIILVMIILFIFIIITLTYSIRFARKVHHHSHGKDRRDVNDNYNDSNDDDDHNNIVNNNNNHNLNVHHTNENERSTPLSSAINVFETALCEMRPETLENDLKCKNSSTTPSSSSSTNITTTGASVAITNPYSAIMDTFKPYHVNMENLSNDQHYQSHQPATSSSALIIKCDLPDSSIITYQNYLFPLTTCESTSATTTTTATTTTTNSMMEDISMMATTNNGACISIDSANVVNNNNNNNNALDTIATNVTNNNNSHSYTFESTNQQPHTASFTRNEFTMNMTEPPATTTMLEQRNYHHLHDLIHNNHHHHNNSNHHHHHHHHGHSAVVNDSRMNSGADDGGNGVDNESFLLSNSFQYPLSVRIVPTDINDANVSNAVATAAQFATGSTTDIYDMNSTNNNSKTNKIHTLNSHWEIVIIQYDMISFSSSSTSIGSISTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAW9</accession>
    <name>A0A922IAW9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAW9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="284" mass="32293" checksum="0DD5C3FCD462DF85" modified="2023-02-22" version="1">MNQEQNYDNLDNSVNINNSIRNNKNVVNVIKNYLILSSAKKSPSIMMMAVMKSKCRHHSSSSLFSSYYYLLWLAVFVFFDLRFWAIDQNFASVEASIVCPKLIPVRKTPRFGKRSADYNKMYPFECLEFKKRLINEFLPMAKIVHSSEISKTNYELIDSLTQTGRSLVASSSAPPIPEGKNIFGVIYGQPNQFEKYFLSILNKHAAESTPTSAPSVDANTTVSTKSLISTSLSPESGIKDSNESSNTDAETTLRRQREILARLFVSYIDKLKEQNQRQQQKQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB44</accession>
    <name>A0A922IB44_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AN1-type zinc finger protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ZFAND1_1</name>
        <name evidence="6" type="ORF">DERF_001050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB44"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035617">
        <property type="term" value="P:stress granule disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF37">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9527001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="227" mass="26391" checksum="F47284A4CDFBC8E3" modified="2023-02-22" version="1">MAELPHLGQHCSICSILDSVQITQSSVCNHCMKRFCLNHRHQVDHKCLKLISNQIDDKKIDSKTDEILAKIRSVYKPGMNVKNRGAKNNPLALKVALMKLKSKAIGLESTPQEEREYFYLSFIANEIGYNQQCKEFRDEPIFLCREWSIGKCVDWLAQKWSLINKNNQWNAPKLILTSERLLIDTNDQRKCCEKQKNFFCFSHHLKDLLADNVIFSTDLLILTYLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBA1</accession>
    <name>A0A922IBA1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_001635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBA1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9527627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="621" mass="71698" checksum="24169CEE8DDF94CD" modified="2023-02-22" version="1">MYIEEKLRQQQIESEMLPMKPQRKPSRKQLLYQRRSQTTPHYMLASCSSNSTLPTRFPIRTIKCLNFHCLSKVFEYVDFKDLINCQLVCSFWNECVKFHLAKRTYFAYGKQYNDLQRMNYDDEKEFQNNTNDSNTRDPLSLSLNSFYSCEKCQAIINAKIAYDRDESNNYAESKSSGLSSTSENLSSSSSLSASQTSLTSSSDSVIDLLDQNNNNTNGNYNDYRCAECQAIFEELKTFTTKTTNNNNNNNSDKQIRQNYYDQFIDAIRLNIFERILSKLPKLRLLKYAQGYRYGFQHNCLDVYGVNLILRTNRHCPHLTNIDLSNCVGLTEADFYQLAKFYGQQLISLNVSGCRIDETCLRLIIKSCDKLRYLNMANNFCRLQGTCLEWISDKIETIVADYNQNVRVLDGLLQGKGRNIIELELNVGYCFNPSMPYKILGNHFQNLISLKIIFKSFGKYKQGIFIHLAKLKELECLYLIEEIDDFDSESSLDDFSVLEILKSCGSKLRELYLHAASSLFGCQSSLTDHSISKIDTFCPLLEVFSIKRASITDQSLNSIARLRNAYTVQLIDLEYISDKGIRQIMTSFRENEDQHKQKLRQICGIDIDVGHNGPNIEQVKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBL8</accession>
    <name>A0A922IBL8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBL8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="345" mass="41138" checksum="A6A3B2ADC1B16947" modified="2023-02-22" version="1">MMTNSNCQCTNARILIEGYRLPMPIEFSQMEAIKQNLCVCEVPSTIRKKYLDFCERESRKSTLIRLLQANYKNIDENPNTDRKEELPSEVLEEMKKFVIEIRRHERQLPCLSDDFECWSDYVDYRQKQQSMLPRSAIRLPSQVMSQLLTTNRPSFMLELNEYYVPIPEDFIVYFYSDIQNRIIAELPETIRSIYLNMLWQYGHQQELISIILPLPRQFNEMTFDQQLESLKNLPESIHENYMKICQNDAKLQSAINLIIDELHAEKDFRQSKSETDSNIKIEININGHHLPLVKDFNRWSCQRRKQLLRNLPDNVRGRYLNLIWQEDIGSRLCAESRPLYQPFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBP0</accession>
    <name>A0A922IBP0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Laminin subunit beta-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Laminin B1 chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Laminin-1 subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Laminin-10 subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Laminin-12 subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminin-2 subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Laminin-6 subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Laminin-8 subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">LAMB1</name>
        <name evidence="29" type="ORF">DERF_006471</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">Derf</strain>
            <tissue evidence="29">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">Derf</strain>
            <tissue evidence="29">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="14">Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin-211 or merosin), laminin-6 (laminin-311 or K-laminin), laminin-8 (laminin-411), laminin-10 (laminin-511) and laminin-12 (laminin-213). Interacts with ITGB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005606">
        <property type="term" value="C:laminin-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043259">
        <property type="term" value="C:laminin-10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22302">
        <property type="entry name" value="cc_DmLAMB1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000011">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000083">
        <property type="entry name" value="Laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000090">
        <property type="entry name" value="laminin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000084">
        <property type="entry name" value="Laminin subunit alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000065">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000130">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000138">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000145">
        <property type="entry name" value="Laminin subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000135">
        <property type="entry name" value="Laminin subunit beta 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000001">
        <property type="entry name" value="Laminin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000224">
        <property type="entry name" value="Usherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013015">
        <property type="entry name" value="Laminin_IV_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF375">
        <property type="entry name" value="LAMININ SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21199">
        <property type="entry name" value="LAMININ_IV_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51116">
        <property type="entry name" value="LAMININ_IVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9 24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 23" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Laminin N-terminal" evidence="28">
        <location>
            <begin position="199"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="26">
        <location>
            <begin position="474"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="26">
        <location>
            <begin position="537"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="26">
        <location>
            <begin position="597"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="26">
        <location>
            <begin position="648"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type B" evidence="27">
        <location>
            <begin position="687"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="26">
        <location>
            <begin position="906"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="26">
        <location>
            <begin position="954"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="26">
        <location>
            <begin position="1000"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="26">
        <location>
            <begin position="1112"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="26">
        <location>
            <begin position="1164"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="26">
        <location>
            <begin position="1215"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="26">
        <location>
            <begin position="1263"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="1375"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="1569"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="1714"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="669"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="906"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="908"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="954"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="956"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="975"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1136"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1187"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1215"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1217"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1236"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1263"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1265"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="1284"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="29">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00075415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00082919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00083431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAH9522918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1911" mass="215505" checksum="6FBEA6B681718A1E" modified="2023-02-22" version="1" fragment="single">TLCQRYPDHHHQREYDEYDRNARQQRVGYNSKPYSHDVSYFKLNETSITSTSNDHHDSQQKQRPVPINPVNGRSSSYEWSRNSGYPQSSLNHRNYYESHHKSRVTDDNRNQQIVSNRPSVIGDGGKHMPGPFIWYNDTFHWAENRSRGYDPDLDGPTLAPPTIEHTYDEEDWDGTDLKSRHKFDDRHPMAIYPSGRCDDFQACYPATGNLLIGREDRLKASSTCGLRQQVRYCVVSHLKEKKKCFYCDSRDRFKGTARYHGIENVVSRVGQKRRQFWWQAENGVENVYVQFDLEAEFHFTHLYINILPMIVVHHFLGIPLGPRNRITDLVCDSRYSNVEPSTEGEVIFRVLPPNIHIDDPYSKEVQDMLKITNLRINFTQLHTLGDNLFDPRIEVKEKYYYAIYDMVVRGSCSCYGHASRCIPSNHETIPDMVYGRCECTHHTKGLNCELCEDLYNDLEWKPAIGRQTNACKKCECNNHASRCHFDMAVYQASNNISGGVCEDCQHNTMGVHCERCRPSFFRDPNRRLDDPYVCQQCDCDPRGSKEEGNCDPYTDPALGLESGRCSCKKNVEGRRCDHCKPGFWNLHEINPDGCEPCSCNQMGTVGNHGCNINTGECVCKRNVVGRDCNQCAPNYYGLGVDEEGCKFCDCDPGGSYSPDCDQETGRCNCRPHVTGRRCDQPEPGYFVPSPDYLTFEAEDAKTIQGSPIITPRNYDERMHWTGEGFNRLPPYSGIEFTIDNVPISKYYDVVVRYEPETSGRFNNAQLMIKRPYGTDVYGPCGNYSTTNDIRTINLSSNERTAIADSICLEKGQRYQMELNANEFERPSYGNEQSPSILIDSIILIPKANDIPFLSGGTPENQRRQYEYEHRCLMPYYNLNRAPEVDEHCRKTLMSAGFYTFDGAQPCSCNPTGSYSADCQQLGGLCQCKQYVSPRTCDRCHVGYYGFGPDGCKACDCHRIGALDNECDPITGQCNCRPETYGRQCDECQPGYWNYPNCQRCDCNGMSDMCDSKTGSCIDCRDNTAGAHCEECVAGYYGDPLGRMTGMVVPCRPCPCPGVEDSGMSHAHTCQLDPRTQNVICHCHPGYAGERCDRCDENYFGDPNLPGGQCVACNCSGNTDISQPGNCDPKTGECLRCLYNTGGPNCQVCKPGYYGNALDHSCAECVCHHLGTDPRSAFCNQTTGQCSCLPNVEGISCNRCADNHWNLASQQGCEPCDCDPQGALSMKCNEIDGQCHCKTTFGGRACNECLPNHYGNPRLQCKLCECNSAGSSSMQCHKVTGDCVCIDGISGAKCDRCARGFTGMVPYCEACGECFESWDNITNILKTETFHLLDKARQIKQTGTTGAYTKQFTQIELNLDEINKILEGQNINKFDLERVQHMIEEAKSNLANLQEALNNHERQLEDTKTNIINVNFKLNALANKSMELELEANQLKNETFALQEANVEGAYNMTKDAQRRSRASRNMVEESSNILTDSQTIRRNTEQLIDQPKGQHNLTYHENDRILRNIQQEISEMENGLPNINNLVCDGFSTIDQCDNLCGGAGCGRCGGISCTHGATTKASTAVELAKKAEKDLQEKDRHVKDELRRIKEAREKSDEALEEAKAAFERIMLAKNTSTNTAVEVNNLLDQIHNFLSDDVAQAKDVREIAEKCRQNTISLDENEIRLLALEINKTIAGLKDIDRILIETRDSLEKAEHLKIKADQVKKKANDILSVAESVKQELNKALEAQRKAKNSIDMANKSIIGIEQDLKEVTGKAEEAKDKTEEAKGKIGSLNDRLNNLTKKFTGNKFNIENAEKEAMAASSSAEDANKYVDDLERKYRLAAQKLDQKSKVSDDLKKRAKALKDNASTLLNNVSVKLKSIEDFENDIANNDQKLDDLRRKIEELDNEMKNHLENIERQSKFYRDCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC68</accession>
    <name>A0A922IC68_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC68"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="384" mass="44188" checksum="5B16CE124B284202" modified="2023-02-22" version="1">MPRRGEISSTIACSLEFRNYRTLYQHIVAVHPNFFVDNSIPQDESPEKLKHHDHTIAFSVSIKSKSQSTACMEKKIITLCSTLIGNNRRYDQERSNRVVATPFTEFILRNETRHVRRRAKKVEALINSPEISSLIKESLRSKFDRANELAAGFSELIPKRTLDKNNALLNQCMQSEEARSLLTLRSTPSRLAYQSNKRAESTECMEKKSSPMCSTIGVDNDETNLSNQRSSNGEKIDGTKIFDHNVNCSPQQQSSSIESMNKSSQALADSNDDNSSVDLSRSLLQQEENRKILKDYDYQYRRLDLIVKTLMDKKASKLTLHRLTQEVKRVLEDWLFPLNDNFYPLFLFDKDANVHFEFFILDPESPVTITNRSPCSDMRIFRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICJ2</accession>
    <name>A0A922ICJ2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">OSBPL1A_2</name>
        <name evidence="6" type="ORF">DERF_001820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICJ2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000005">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000015">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF209">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="379"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="477"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9527826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="605" mass="70018" checksum="2AFAE706B5565544" modified="2023-02-22" version="1">MEKSSLILHTLNNNNNNNNTPKMDSNNVEQHSDLLFSMENCNKNHHDNGHHHQDGDHVGALAKFNHNSQHRDRLPAPMVPRDEIGLWSILKHCIGKELSKITFPVIFNEPLSFLQRMTELFHYTHYLNIADQCDDIVERMENICAYIVSAYSSNWLRLNKPFNPLLGETFEYEIKTSQTKIVCEQVSHHPPISAWHAESPHFILRGTSAPKLRFWGKSIEVKPEGTATLELKSCGEIYTWKSVNCCVHNIIVGKIWFEQYGTVEVANHMNQFKLLINFKPAGWFGYDLNRLDGYIQNVKKEKLRFVYGKWNDYLKSASIEDYDEYLKANNNKFRAPDKPIDIGASDGSGQNDHHSFNRSKMMSKLNSLTKQLTGSLDLGVAIGGSSNDQQQQQTDDNNLPPEAIEGDMPKSDSSHSLDINNSRILWKAEPRPEHSSQYYNFNWFTFGLNELPGDNNERQELLKRLPPTDSRLRPDIRKLEEGDLDAAAAEKNRLEEKQREARRLRKKGKMKEFQPLWFRPEFNQYTGQEDWVFKQEYWTKQKGYKVIENLILDLKLPKLYECSVFVPAPGHIYIIIKKEFVLPSVRTTTLSENVMAFKNKNSLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICK2</accession>
    <name>A0A922ICK2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_000302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KIN17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICK2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2030:FF:000001">
        <property type="entry name" value="DNA/RNA-binding protein KIN17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25088">
        <property type="entry name" value="GPKOW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9526203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="422" mass="48936" checksum="8D1BE29F260C1B85" modified="2023-02-22" version="1">MGKHEPLTAKAIGKRIKAKGLQKLKFYCQMCQKQCRDANGFKCHLTSEAHQRQLLLFSENPNRYMDEFSSDFLKDFLHLLKRRYSTKRVLANQVYQEYIKDRDHLHMNSTRWCTLTGLVKWMGRKGICHVENNEKGWFITYIDRDPETLLRNENKAKKEKMFRDDDERQAQLIQEQIERGKRSEIEYRLRNSQNTDDTDQESNQSSKQILVKEDPDQKITFSLAVKKSLNCQPIATIFNNVKPLDSISSKTQNKVDTEKKSSLESKSKSKKSALEEILEEQERWKARKAASQHRSNNNSGSYKSETWMQPGIIVRIVTKQLGSEYYEKKARIESIESPGYAAIIKLLSNGDLIRVDERHLETVVPSKSGSKVMILKGLYRGQLATIVRVDEQNEKILVTIDSRSSGSSEPIHCNFDQISKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICP5</accession>
    <name>A0A922ICP5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_002572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICP5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261">
        <property type="entry name" value="BEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21261:SF15">
        <property type="entry name" value="BEATEN PATH IIIA, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9528650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="498" mass="57224" checksum="5C4F0031CA37CF47" modified="2023-02-22" version="1">MAPDYIFYRDPMWLNCSVIDLDYNQIYSIKWFKDNDEMYRFITADETSPRTFYDTPGIVIDESRSNYGNLYILHADFKTEANFRCEVLAENDFTTAIQIKKIRVYYIPRDGQPIIVGKKSHFGPNEPVNLTCTSPMSTPAARLVVNLNGNSLVASNSNNNVNVNDNDVIKNNQVIMRTYYRHFENGQSSTSVNVQFPGSWLQTKRINQFECTSSIIHRYNRTASLRVEWKIDPINNHTLYVPVLDHNINNNHLQDRLAPRIENFKKKYNLGEPISLRCISSKYKPMPELYWLLNGQHVDAQYLDYKQSDFNQNGFIRLDLKYPLNGGQNNNDNNGHQHQRNLHSHPHQHQRRQHGQQRMNNNNNNNNNVNWNNKRQLSSSNLNYDSNVVVSIDKQQQQSTIDSYHFECIQILSNVISVSSEVVQLYGTSSSSSSSSGSNHELEQSLNHGNSVEAVKSFIGNGATITTLSPSSSLLFIQQLYSLVFMIIISIPCILNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICS1</accession>
    <name>A0A922ICS1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="9">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="9">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_002367</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="9"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICS1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="11">
        <location>
            <begin position="39"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9528418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="257" mass="29014" checksum="667F88EAF4CDE3C6" modified="2023-02-22" version="1">MSTTTNTTMVNDQQKNNNNDDDINVIIVNDDDDDEHPRKLIPKLCRQMYQLGWVTGTGGGMSIRMNDDIYIAPSGVQKECIKPEHLFVLDIDGNVKNLPPNELCLKQSECTPLFLAAYKQRNAGAVIHSHSISAVLATIITDGNEFCVSHQEMIKGIKRGTTNENYRYDQTLIVPIIDNTPFERDLTNQLEMVMVKYPDTNAVLVRRHGVYIWGSTWKQAKTMAECYDYLFNYVVQLKQFGIDPVIVSSTNGCSSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICY5</accession>
    <name>A0A922ICY5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICY5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="253" mass="29162" checksum="71793D2D8402105F" modified="2023-02-22" version="1">MNSMKESDISESDDMTENDGESTEIDESTNEDKVANADDDWLDVEKMPEIFDFNGSEGLKRNLSPDITPFEAFSLIFNNVLVEKIVNWTNYKAKVQRSKRKYMWKDTDAQEIKKILSSVMGSVAQELPDITILNDSNFHRWAMEIELTMKGKKLWKFVIDNNINDSEDPSKFMAMAFIVRTVDETNFHQISGCDSVKQMMDKLIQYHRGCSSKSTEISSDQPEMMIEDSVDPNQTENIDQNENHQRGRPFISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDT7</accession>
    <name>A0A922IDT7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDT7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="124" mass="13902" checksum="CACFBA4A635E39FB" modified="2023-02-22" version="1">MNASTFSLNLFGYNSLRMLITLYMAICLIYSLKLTIVNASPVVNIGKNSGTNHDHSTHQNSLSPTDLISNTEYFRQMLSNGSGFNKTILFKREDVTDNIVKILRNNPNDLLLTNQTDHHLGSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE55</accession>
    <name>A0A922IE55_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptor 83</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Neuropeptide Y receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GPR83_1</name>
        <name evidence="14" type="ORF">DERF_002961</name>
        <name evidence="13" type="ORF">HUG17_5006</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE55"/>
    <dbReference type="OrthoDB" id="6506432at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="20"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7641961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9529052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="520" mass="58991" checksum="476079F259F0E5B4" modified="2023-02-22" version="1">MSSIVIVISFSLLIVVSFCGNTLVCRTLFRQRRFCANSTNVLIGMLAISDLMMTIFNIPFTVADIILNDWIFGDFVCILVSFVQANSVYVSSFTMAVIAIDRCKAIYKFRPQQSSNDSTNNNHIANNGRNINENTGTCNDNRETSNNRPNGGGNGCCCLMDCFIFNISCPLIKSNNKSVHLSSSSQQPQSETSKTRTTRFKLELRTKMILIISAIWIMAALHSLPHTIFNRVTVIEMNNIVVESGLTNTNNNRASLHENNRKNDFEQGIGTTEIATIEAFDDSISMDSDKNSNHKYPKSSSSTTAMIMETNQTRTIRRCIPVTPTWFGAKFSLWLTLYTTATQYIIPLSCAAIIYTRIAFTINSQGKVGQMTESRAEKINKHKRRRLLMLALIVAIFAICWLPFNVYYLLLDFGITKSYNHTAFLFCLWLATSSVCYNPFVYCWLNKSFRQEAKNVWNCLSQLFSCFCCKGGQQQQQQSDQQLQNNQIQFQRQSQNDHIKRKPQSLNLNENQCQHQTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF12</accession>
    <name>A0A922IF12_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF12"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6999" checksum="B2742EA3C48D7ED5" modified="2023-02-22" version="1">MVVIFTRSVGPYFFDENEKEKHNKQTNKISTNIDDDDIYQIASQPDKTVTFIDRYDDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF53</accession>
    <name>A0A922IF53_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate synthase</fullName>
            <ecNumber evidence="3">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_003939</name>
        <name evidence="11" type="ORF">HUG17_5784</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF53"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000002">
        <property type="entry name" value="Possible thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7642737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9530105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="289" mass="33238" checksum="3EC738185DAAB7B6" modified="2023-02-22" version="1">MKHDEYQYLDLIKHVLDNGAEKNDRTGTGTFSVFGTQSRYSLRDQTLPLITTKRVFWRGVVEELLWFLQGSTDSKKLSEKGVKIWDANGSREFLDSLGFADRQEGDLGPVYGFQWRHFGAEYRDKNSDYNAQGVDQLKQLIHTIKTNPNDRRMIISAWNPTDLPKMALPPCHCLAQFYVNNGELSCQLYQRSGDIGLGVPFNIASYSLLTHVIAHICELKTGEFIHTIGDAHIYRDHVDALREQLTRTPKPFPKIQFKRIVNDIDDFKFEDIQLIGYDPYAVIKMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF82</accession>
    <name>A0A922IF82_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retinitis pigmentosa 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RP9</name>
        <name evidence="2" type="ORF">DERF_003716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF82"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034585">
        <property type="entry name" value="PAP-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35252">
        <property type="entry name" value="RETINITIS PIGMENTOSA 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35252:SF1">
        <property type="entry name" value="RETINITIS PIGMENTOSA 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="243" mass="28381" checksum="4EAB9AE0693BCECB" modified="2023-02-22" version="1">MTESSKTKKKLSKIDEKLLDTLKHYDSFYEKPPPGLFKENDEEKPEDVIPDLPENKAAREFLAKAPTKGLWMPLGKEVKVMKCWRCKIYGHRSGDKECPLFMSGNRAMEEFRHAHEDPMYNYIKENEFREKMKKVEMLKTLLQQSDDDDDDDNDKHGKKRKKKQSTSSSLKKKKEKKDSRRNKHRRKKSSSSSSSSDSDSPSSSSSSSSSSSSSDDHHSKRHKKKRKKEHSKKHRKHHTSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF84</accession>
    <name>A0A922IF84_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PTPRZ1_1</name>
        <name evidence="2" type="ORF">DERF_001577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF84"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="106" mass="12304" checksum="D6F220DD124969B9" modified="2023-02-22" version="1" fragment="single">DLGQLEFHNIYTRRGSNATIACEPASRATKIYNIQWFKDERKVVEIENQRIINWQVGDHVSFVPETGALLLRSVSFRDSGDYLCLVNNKRENGQVRLMVQGKKKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFE5</accession>
    <name>A0A922IFE5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidylcholine transfer protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">START domain-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">StAR-related lipid transfer protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">STARD7</name>
        <name evidence="13" type="ORF">DERF_003826</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with ACOT13/THEM2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFE5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000017">
        <property type="entry name" value="Phosphatidylcholine transfer protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF8">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="12">
        <location>
            <begin position="221"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9529978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="500" mass="59834" checksum="D63F4BA1B592F023" modified="2023-02-22" version="1">MFRFFMTAKQTPKNIKIFQNSNFRTQSSSSSSKPLKQYSDWYGKLSQNDTKLFRWLAKTTLIKERIYDNLIVFTRILHVQSNVYLTLQIRRIAQLCHLYRRLYSPSEFQLVINNLKFFKFLSHEYRNYWKKYFLQRLVLFSYAVCCAYNWEERINDNEFDELIQDFIHNYEQNQVEKESNVKVNRSNDDDDDRCVLQDNGDTSFMVVNCMEADNSSVITEWEEIIKRENFHVLRKSINNSALYQYKVFGSFDDISAYSFYSVQKDLDYRKKWDKLVIKLDIVDVESTKPKTVSKRHRLYDTGNELIHWIMKYPYPMMNREYLYIRRSIIDFQRNFIVLISRSVTNSNITESQEQVRVYNYMSHMVIRPYESFDKPGFEFMLTYFDDPRASFPSPAYAWMAARGVPEFVEKLHQAALKFANEKPMENIFHQFTIVDQDDDDDDDDNDETFVINKFETPNEDEITNGSETAATKLNKDKINKKNFLARLPEPIVDFDSLIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFI4</accession>
    <name>A0A922IFI4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFI4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070290">
        <property type="term" value="F:N-acylphosphatidylethanolamine-specific phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070291">
        <property type="term" value="P:N-acylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="222"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9530068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="481" mass="54922" checksum="779BCB60050249E8" modified="2023-02-22" version="1">MIQKFKFLSKRTNSCEQNDDYNNNDSSVITSGSEKKLVSRNAVICSSGKDKYRHDSERANIPIRPVNSELEYVPESNNNNNNHLKVNNPIHASRQSMYCTNDLIASTSSLCPSHHSQLSRQNSTTSQVVKRHTVVNRLDLESSMMIGGKFQNPWPNYRSPTFTNILKLGLSRDKSNVASKKDLNQHLPILEPNISTEPPENSFRITWLGHASVLAEFDNMAVLTDPMFSERASPSQVIGPKRYRDPPCTVHDLPSNLDAVVISHSHYDHLDLNTVVLLNARYGSDLRWFIPIGLGDWFGRVGCENVVELDWWEENCVPDKNDVSFVFTPSQHWSKRTLTDDNKSLWGSWVVKGPRYRFFFTGDTGFCDVFKRIGSIYGPFDVSAIPIGSYEPRRYMKYQHINPAEAVQLHKDLRSKFSVAIHWGTFAFSDEHFLEPRNRLRIEAEKARINCKKFATFMHGETRIITPSGKVESTHQNKIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFY1</accession>
    <name>A0A922IFY1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sterol O-acyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SOAT1_1</name>
        <name evidence="10" type="ORF">DERF_002594</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFY1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF8">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9528674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="498" mass="59881" checksum="552A423EF4DBB051" modified="2023-02-22" version="1">MIANNLASATKQFQIRDSLVTILVNNDPQVRTLHNFCWLCSFVYAATKIGDYLFNAQKYDEEFKFAMEIIQRNVVDIYNGLFVWIIMNTVVFSLHYSLVLINNFNQFQLLIQIIDDNRNKNSGSSIENGETIGTGQLYKQFHSRQQSRLYQRLLIDIIYMLITLIGLIVFSTASILMYDFQFIGSIMIMAEMFRLTLKAHSFYVENRDLQISEEELQLLIKNQLIQSRNWFKIFSVWQSRPKFNAFCYFLFAPTLIYRNSYVRTKTIRWNFVLNYCCQMIFILVVWVYIILSCTVKHHMHRIGSHVYYWRDLYGHLFTLWIVGVFNYYCFFYTLFHLWHNITGELLRFADRHYYEAFWNARSLKQFYRQWNLIVQDWVYHYAYKPINQWTNNRWITTIMVTFVSAVAHEYIIAISLRFCFPLIFLCFGFCGFILDMINHYLKYKRWQNMLFIFQFYLGFGLMTLGYFVEVLARIECPENSSSILQYFIPRIITCLTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGI7</accession>
    <name>A0A922IGI7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocon-associated protein subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Signal sequence receptor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SSR1</name>
        <name evidence="15" type="ORF">DERF_003239</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAP-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGI7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037295345" description="Translocon-associated protein subunit alpha" evidence="14">
        <location>
            <begin position="25"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9529349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="290" mass="33065" checksum="319D86252A6482E9" modified="2023-02-22" version="1">MNLIRNILLAFLFILPLLTLFNNANNFNVKAVEDDPVEGEDSDVNVETGDVIKTEEEDDSTLSSEGYRNSPDADITYMFTKPLGNGLELPVGKEVHFLVGFMNKGQKDFFVDTMDASFRYSADFSYYLQNFSALAYNRLVKPKQEVTFSYQFFVSEAYSPRPYGLTINLYYRDADNVQYLTPVFNETVNIFELDEGLDSETFFLFIVLAGLAVLALVGIYQLFQSYGKKHIPMPSSSKPKYETGTSNHEDVDLDWLPKEGSKYYMKQLSNAHKSPNPAKPSSPRQRRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KRI0</accession>
    <name>A0A922KRI0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ARF6</name>
        <name evidence="13" type="ORF">DERF_015787</name>
        <name evidence="12" type="ORF">HUG17_3786</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KRI0"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000286">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7639753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9491051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="175" mass="20021" checksum="DB9169D458534882" modified="2023-02-22" version="1">MGKFLSKIFGSKEIRILMLGLDASGKTTILYKLKSGQTVTTIPTVGFNVETVTYKNVRFSVWDVGGQDKIRPLWRHYYTGTQGLIFVVDSTDRDRIDEARHELHKIVNDREMRDVIILVFANKQDLKDAMKPAEIQDKLGLTMTKQRNWYVQPACALTGDGLHEGLTWLMSYHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KS51</accession>
    <name>A0A922KS51_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_016078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KS51"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF25">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="SWIM-type" evidence="4">
        <location>
            <begin position="801"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="984"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9491351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1012" mass="115204" checksum="E58A0AE189B2B405" modified="2023-02-22" version="1">MDRSAIHNSNGPSQGLIHVPGCDTSNGTSNVTNGPSQDQIFSSHQVPIFSRQHVPISVRNVTNGPSQGLVHVPGSDTSNGTSNVVNGLSQDQIFSSHQVPIFSRQHVPISVRNVTNGPSQGLVHVPGSNISNGTSSVANGQHVPISVRNVTNGPSQGLVHVPGSNISNGTSSVANGQHVPISVRNVTNGPSQGLVHVPGSNTSNGTSNVTNGQHVPISVCNVKNGPSLNNDASIGKIPLHFCERCNQSFNSKWNLKRHNKRIHDVDKSTSKNLYECCLCRKKYAGYLAVHLKSAHGVEIQVKNLEFKDFEMFKSFLEKTEEETCSNYLTRRIERDSNQQVITANYICSRRGTIPANRSERKRAPKSNKTIKIGNICPSQISLTRNKNGTYTAKWTTTHVGHELDMKFCRLPNKYKESIAHYLKIGLQPSVIKKKMRNLLDDSDKITMAQMVTTKDINNIKKQYNTEDIAEESLSTFIDYLKTSSCSVIYFKDIGKAIDGFHEDDFLIILQANSQKDMMKENSEIISIDSTHDSSIKGLILTTIMCRDKMKVGYPCAFLLSNKVNFKFITFYFEKIKINLGQNLKSNIVMTDMEILFSNAWKHIFGNCIFLYCSFHVKKAFNQNLNAKISDKKIRDAVRSSVMKLLTNLDPQNFENEKNKFLDNYLHQNETNGFAKYMLQYYLANDSRYPPERWAYCHRTQLGINTNMIIENFHKKLKHQYMDGKKNRNVTSTLKKLLHIISDYEIDSVVRINRGYIPTKVRYLRSKHAESKKMVIDNFKEIDHSCGIITLKYWSQEKKRYYVISINSNQDPDCEIKCEECKLCLCQVSCNCHDFIIRNNFCMHIHLAYSKYVSLHKEQTNIELQFEEEINPPDILDQTVSISYENDTFKLTKVENVFNGYKPIKKIEKKQNSINFISRKQLTDFAAPENVQQKVSAFWQTYTKEEKRVKNTMAKINDIYSRSQQLDEDQYNELVAHASSIFPHLFKNDNDDRKKNLAPQKRQKTSKNVDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KTE2</accession>
    <name>A0A922KTE2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formin-like protein 2, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FMNL2_1</name>
        <name evidence="7" type="ORF">DERF_014615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KTE2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF4">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="5">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="6">
        <location>
            <begin position="258"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="4">
        <location>
            <begin position="805"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="758"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="826"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="730"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="759"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9493888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="851" mass="96020" checksum="567B8603962580DE" modified="2023-02-22" version="1">MVACMQFINIIVHSVEDMNFRVHLQYEFTQLGLDNYLENKLRNMESDDLLVQIQAYLDNVFDVAALMEDAEQKNVALEQCQQLIQQVANAHEAERDWESKFHELKHAYDSLEKDRLDLAELNQHMNDELTRLKQSVCELEESRRRESLLESRINELKRMSTSGGGDIDSNLVNSDTTTGSKISSTLSSSSSSSTTTAATVPQSPQPSLTVPPPPPPPPPPPPPPSISMVPPPPPPPPPMASGAFGSSTNDSSNMLMTLKRTYQTKYKLPTFNWVPLKPNQVKGTIFNDFHDEETILKTINFDDFEEQFKLGIKSFGGKKGGLIGQDQRDSSGMANGIGNNNTGGDVSKRFKVPEKVSLLQHNRLRNMAISMRKIDLDTETVVKAIHSFDTNILSMDYTEVLLRMIPQPEETKSYREYERQGRLIDEMNDVDKFLLQISKVERLEPKLRIMFYMNNINLPVDSPAFNHKPGSGGGDGDATMVITIITQYMQRIKTIREAAIAIRTSPGVREILEYILVFGNYLNCSTRTLATAPAYGFKLQTLDLITETKSSVDRSRSLLHYLVDVILVKEKPGGNHSGPSKSEVLATALAIRPLLISNRSQHQLTGGNSDASVLENIKMPYDFDHLLQIIERATSVSLETCVAEVLEIEKGMELCRNELQLRNQGGLASSPATKILQQFIQQKGPEVSGLKDELRKTQQQYNECVEYFGENPKMLESSNQLFGTFVRFLKNFKQCQLDNLMAQRKRIEEELRRQILAKQQQRMMQQQQNNSNGGSQSDQSGNHNQQGQATSDNQKVKEKRLLKQDEVYNGALEDILSGLKNEPFRRADAVRRSQRRRQANMTTNEMQDNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KTL5</accession>
    <name>A0A922KTL5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Exocyst complex component 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exocyst complex component Exo70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EXOC7</name>
        <name evidence="7" type="ORF">DERF_014073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KTL5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="6">
        <location>
            <begin position="314"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9493316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="725" mass="83748" checksum="C86C89264D7B64B7" modified="2023-02-22" version="1">MLELEDDRRKLANATNSLARLKSLLTSSTDNCMKMVETLTQFDDRLLKLEETVQPVYKQTGNLQRQQENINSSLKRLDYVIKFYTVAGEVEPNIINGPGSSSMYGEYISDLNRLTDAVRYFERNNRESPELMNCGSLLEKGGQIIQKEFRQNMSRHSEEIKKVDIILDMIKSNAPQQEPDLYKVFKLSDRRNGGGGGIGNPEKILQDLKLLAEWLCYNRNQDFLLLYSRLRSDVLSKSLKNLRSYLKSSTLGSMIKTLGAHLSPLLGGRKNLHLMKRIDISTSTTSSSSSMDKDNLLDINITEPEIFAYVLTVTGLLKLMQLELSLIERIIPVEHQKTIFSRVILSSLESVYNEGEQLSTRVKRSVQKQDFSSALFLLPVLRYHAYMRHSFDLLLDGCDPQVSNRLHSLVVTLQTTISKTLEEFIEYIKCDQHHHRVPKDGTVHELTSNVMLFLVHLQSYLDILSRVVTVTDIQSLELSGDKNRIAFAQYIWRVLSAMGLSLRKRSESYHNDQALQSLFLLNNTFYILKTLTTSSLLSIVSLYRSNIRDDYQIQIREFKMEYYKCWNKVVHYIDEINNPTILSPQRTGTMSSSSSYSTLSNSHSSSYSLSGISSSTISGHHHHHHTQPMMMIRLKDKDRQIIKDKFAGFNKEFEQVIQSHRSYAIPDRDLREEIKKELIQWLNRIYFQFYERYVAVEFTKNVHKYIKYTPDHVSQSISLLFDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KTW4</accession>
    <name>A0A922KTW4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KTW4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7616" checksum="5F1EF4E4C4720E21" modified="2023-02-22" version="1">MDMKQIGKITKKTNGQTKLDHHNGLVYISNELWNQQQKVFQILMTQQQQQYKLWQIIFIIIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KUS7</accession>
    <name>A0A922KUS7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asterix-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Protein Asterix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">WDR83OS</name>
        <name evidence="9" type="ORF">DERF_014656</name>
        <name evidence="8" type="ORF">HUG17_6561</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asterix family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7644199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KUS7"/>
    <dbReference type="OrthoDB" id="284718at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005351">
        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193">
        <property type="entry name" value="CGI-140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT ASTERIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7644199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9493931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="109" mass="12513" checksum="3F10852CB956D60F" modified="2023-02-22" version="1">MSQMNSNDPRRPDRVQRYKPLPAGCIGSPSEDPTPDYMNLLSMLFSMCGLMMKLKWSAWIALFCSAISFANLRMHDDFKQIFSCFMLSFLAVVMTYLQNPLPMTLPFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY08</accession>
    <name>A0A922KY08_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY08"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7487" checksum="75A09DF88595ABC3" modified="2023-02-22" version="1">MEEFIDDNCIFEDPMDGDDYNIIILYLVLVSCSRKPLPITLCKCSSSSSSSSMNNIRRFESISTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZ94</accession>
    <name>A0A922KZ94_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZ94"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7441" checksum="1B49DE42BB21B48C" modified="2023-02-22" version="1">MEANVRPNESNESSRSKEILCPLLQIVNTIMSLNFLMDPGSPMATIFIELNTGTGINDDLSFDHDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L242</accession>
    <name>A0A922L242_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L242"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="6973" checksum="EDF61D3CDAF5DCE5" modified="2023-02-22" version="1">MNGDGDDDDDDDCDDEVVGNALLETPIENQKNVHHKSDIGMNRFFTEYPYQFFNGVTRKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L253</accession>
    <name>A0A922L253_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_009022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L253"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037320033" description="Lipase domain-containing protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="92"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9510501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="197" mass="22701" checksum="9BCB2B765EAB8908" modified="2023-02-22" version="1">MNLSSSFILIFTMTITFCPLDRAQLLLSLKNSSSSILMANNNRLSTVDSITNDLRIHRQHYSDRRYRLSSNRQKRNSTNTVAMKLSHRIKCKNAIRLLLLRDDQNVIFVGWRSLNELFVAAMIIQSYSLYLARFINFLKSKYHLNGEQIHCIGHSLGGFMCGFAGDITFIGRVTVMDAGPRPYFQQKPPQQRLNRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2E1</accession>
    <name>A0A922L2E1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2E1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9515983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8579" checksum="FA69ABEE44CA20F1" modified="2023-02-22" version="1">MTDIFSFFSHFEFVIYHQLMFICVNRMIKTKKQQQQQQQQQKRIFCSTTPLPPTTTTTIIIKNSNHQILITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2K4</accession>
    <name>A0A922L2K4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2K4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="7889" checksum="78999F9A07FF15FB" modified="2023-02-22" version="1">MNIVMMTTTIIWWSIFFVFIEKIATLCISTSTLGESIIKSSPSLCFNETNDNDDDDSNIFQSSFGAIINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4R9</accession>
    <name>A0A922L4R9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_008853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4R9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="172"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="400"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9518263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="68206" checksum="471FF1C4A529BB62" modified="2023-02-22" version="1">MFNRFLCIERSIFNHRKSLIDHQSFRLNHEDIPIIKIPKYMENNLGNTIYQEHCKVKETREKRRQKMANPLNPNHLNKKIISWTGDKKLFHYYGRRYNTRDVPLISKFFLKETSNGQYMTVHNFDTNPSLMSCDHPKSFDSLGLGQNLTQSIYDTVNSGQSIFPSTIQSAVIPLLLRYRNVVFSAETGSGKTIAYLAPLIQLIQQTKVVNSNRNRKCPFGLIVLPSRELTEQVGDVAKQLCANTDVGVATMIGGLPKHLHQTGIDLVITTIGIIESHLNNGVYSLRNLNHIVFDEADTLLDDSFAYETMDLLGKLNINHGQNHDDDKEQCNIESDESHVLNGTQLICASATMPMALDSTIGSLVDMQDDIDQISTKNLHTLHPNIKHRFFRVNRHKKDIKLFELLFESQAQKSPVIVFANRAKAVDWLFKFINENGFNCVRLTGTMDEEERYQSFQLFQKGEYDILVATDLGSRGLDTSRVKHVINFDCPHYVSDYIHRSGRTGRLGSSFIGHVSTFVSFKPDAYMLMELERALRLGEPITTVNANIKAQISQHRVDKWQKIQRNKSVAIEVRAKSVHLRSNSFNVSFEVPFSASGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4Y6</accession>
    <name>A0A922L4Y6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho GTPase-activating protein 42</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Rho gtpase-activating protein 26-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARHGAP42</name>
        <name evidence="9" type="ORF">DERF_010379</name>
        <name evidence="8" type="ORF">HUG17_0332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4Y6"/>
    <dbReference type="OrthoDB" id="3183924at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01249">
        <property type="entry name" value="BAR-PH_GRAF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07602">
        <property type="entry name" value="BAR_RhoGAP_OPHN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11882">
        <property type="entry name" value="SH3_GRAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000001">
        <property type="entry name" value="Rho GTPase-activating protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047234">
        <property type="entry name" value="GRAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047225">
        <property type="entry name" value="PH_GRAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552">
        <property type="entry name" value="OLIGOPHRENIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12552:SF1">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN GRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="461"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="1126"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="861"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1005"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1072"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1012"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1091"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7644794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9511960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1185" mass="135168" checksum="A84A7EE08BC5FF82" modified="2023-02-22" version="1">MGLLPLEFTDGLTDSPFFRETLQSHERELDLTNTAIKHLIKDIKDLIAAARNLSRAQRTLSDTLNNFNFECIGNSQTDDEMVIANSFKDFARLLSTIEDERDRLLEKADEAFLEPIERFRRDQIGSAKEAKKKFEKETAKYCQNLERYLNLSVKKSETQLWEADANNSMEQQHFFKAMSEYVLKLQEVNERKKFEFVETVLSFMLGWLTFYHQGHEIATDFYSVKMELQMRLQRTRNNFNMTQEETKSLRKKMLDNQEKFRQKFQDSCSSKKTYSRQGYLFLMEKKAFTTSWTKHFCKFNKQTKRLKMIQYTQTTGKIVSTDEITIKECIKRNQDTIDRRFCFDIVAQPEILNSNHHHHHHSGHNHSATTNGGGSNSGSVGNNMAIQKHSNNSQNTNSSSNDGSAQVVIYTFQAISEEDYKYWLETLNARDPYPTNLSGQKSGKQNSNKINSDNLKNTIDSHLNETYQLDAEGYWFVKKCIRTIESHGLDQKGIYRMVGVASRVRTLMDMFAQSKSINQNHEDHEHDIDRTDLLPNFNVDSEDFETKTLTSALKSYLRNLAEPIMTFQLHHLFITAAKLENRALRIEKIHQLVHRLPPINFKVLKILIEHLQKVAKLHDKNLMTSSNLGVCFGPTLLRTAEESVAAIMDIKFVNVIAELLIENYEKFFLTKPTQMELEQVQPITNYLTSTVNQNYMNSQIQQRPLPNVPISQQQQQQQHYAKTIYETPMSTMNNRLLPPSLNQQQSPTNICRSNSQDQLHTANIQTKSRALYCNNQNALNSVGQNMNGSSTAMLHAQHSKQYSINYSTYPHYQIQPQQQQQQQQLNCNNTASRRALHLSLSSSSPSPSLGSTTLSTMANTLQQQQQQHLYSQPHQQQQQQQQQHQMFYKQIPANSIYGQIRTNSNHLLQPSISYQNLHYNNELSAAFSGDAMQKKSPTGPNSNIIYNRPMTSIGIMPPNSNYASLLRSDSNETGSKLESISKNNYSPITNESIALQSGFISIPNTQSMQQHSSRPVNFSSSSSTSLPSTPEHSQFPYKLPPATMIKSATTTSAMNRNPIVDQTGSTTADPIIELYGSSAGGGSVVNHPHHQQQFNHQQQQQQQQQPPVSKPIYASISSPSSPPQSSIGRTVRTRYVCIGGTDSELSFQPNMIITNVRPSREPGWLEGTLNGKTGLIPLNYVEYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8J5</accession>
    <name>A0A922L8J5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ring finger protein 145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_005303</name>
        <name evidence="11" type="ORF">HUG17_3652</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8J5"/>
    <dbReference type="OrthoDB" id="4348522at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025754">
        <property type="entry name" value="TRC8_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF191">
        <property type="entry name" value="RING FINGER PROTEIN 145 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13705">
        <property type="entry name" value="TRC8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="570"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7639619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9521667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="650" mass="75808" checksum="E067CE2CECF9B659" modified="2023-02-22" version="1">MNSFKNHSRSPTTTTTIKIDMKRMEKALIALLRMPGLFLIDNYFKYFNYNWSIRHRDWNLLLSHFALLNGFLLLLLPLSYLKRYYIHLICWITFVYLSRTLFFIDHHLVPQLVATSSSSSIIAVDDDEARNILIFIVHFVFDLIILSIFKAPKKLYQIGFVGYGIMAIIYATDQRTIGGVGWLKILDTMSYGIGSFTLLNYFFKHTPLFLIDMKTLAMDIIRLAKNEGFHTLYWQTFEQIFVPFHFFLFWTLTILTKIYYLQMFATTVNDNQNDHLEWIPLLLNSVSSIFISPVSLLSTSITVAYISCFILNTIKLYLSGGTDYQNHNQQQHHHHHPIAAYRDHNGWEEGMTTMLLTTITAFTDMNENTRMAVMVIISFVVISSLLQSILEISEPVILSLNMNHNINRIHHLKVLLLCAFLFIFPLYVTNVYAKIFPANFWIAVVFSTSLLISARVLDLIIIHCLFWWDSCRTESWEYLDEIIYFARSFTKFIEFIISISVVIVGIWEALNNRSNILNATILIMHGYYNVWQRINHGMNSYNRRRQANRIVDQLCLVENVEQLNKYDDLCSICYSEMKLMKSSMVIVITDCKHLFHRKCIKKWLAIQNRCPLCSTQIEEADKSVNQSIDSPTAATTMEQSFVEEIKSENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAT1</accession>
    <name>A0A922LAT1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAT1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="7989" checksum="7157C0209F02C12D" modified="2023-02-22" version="1">MGRWPPLYGNHNDNDDDGGSMKSGSKTGSRSGYGSFFLASFLDARKKHPKTIIGHEPKEKKIGHKVEIFTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBD1</accession>
    <name>A0A922LBD1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBD1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6773" checksum="175B158809D2A2B7" modified="2023-02-22" version="1">MSLFFHSKLIGLFMNININIQLNQIEKDTLDTNMGSYLNISNTVEAFESDSEFSIKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBN9</accession>
    <name>A0A922LBN9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_003646</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBN9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9529779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="389" mass="45431" checksum="5CC094DB00B61BB8" modified="2023-02-22" version="1" fragment="single">NFRENIADSKYILLLPLIGAYELWNSDDSGSKSHLFPYYLLINASIVLFAYRFNVSFSLFILFNVGIFIFVHQTLFNLFPIGFLLLIFNVIALKTLRTLARKYSKCFTFAEFAIVFQCINYYLISIITFNWQYWIDGEFTAYRKLDKFCLICYSTLAFHWIVAKWIRISGLDPIIYLISFPLSLYGFLYHFLHIEPLYWFFNFLSFNQTRIYLLLFWSLVLLLTLLFAYIHTFHTVHRATTTATRKIFHLAISLVYITGIKYDVILLDFASKLILFIFIFIEIIRLSNIPVIISIINTIFDRFRDEKDSGILTLSHIYLLVGCSSPLWLCNNLHHSNQISLASGIMAIGIGDTIASVVGITYGNRRWPKSRKTYLGTFASHQNFNLIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBU9</accession>
    <name>A0A922LBU9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">ATP synthase mitochondrial F1 complex assembly factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ATPAF1</name>
        <name evidence="7" type="ORF">DERF_003835</name>
        <name evidence="6" type="ORF">HUG17_5699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBU9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7642652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9529989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="329" mass="38170" checksum="A15C38FEDA611EC2" modified="2023-02-22" version="1">MNRNLRNLTQPSNNVLPLCYSLAINPNNPVNKLLLSTDAIVNAEQQQKQQSLKKSIEENPYYSKYAEKIKKAQLSSSSSLKVDDDKKIESPDKKPTTTIVESVAEDCEKLKSEINTIKVNKANISDKSSKKKLDDIVKLDLFMDKSKEEIIQIWNQYHSKRDCLYAIIESSLYETFHRNLCEYSAFILPLPRRNSDNNDDDTATTLSSYEFFLMQFQEHCCHFTPLAAYHLRKEMAPVCLTIYYYPELTELKGIVLMMGEFDSNILNIMECQALANQLQYYYLTKDPSARLSLHLFNKEPKSFDHMRLIRHLEDGFHSTQQQINLNQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCL9</accession>
    <name>A0A922LCL9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCL9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="358" mass="40587" checksum="CCAEAE3B1CAC1986" modified="2023-02-22" version="1">MKIFKNSLHFPMKKSLTTSKSIMNNDHHYGKHCRTSLQSQMRTNRISTIDKQIQLIALSVLFCGSWLLWPWPSSSTSTSILSSFISKSCIQVQAYPIKPSPSPSSSLSSLSSMYGCNITVYPENNGCHPLQATCDPESQLCICSNLLDDDKIYGDDHDSDNNNNDNESKKQRHYQHKRIDIYQCLPRKKLGQKCQHSAQCYSMITGSGCYRQQQQQQNGNNHLMWMMTNGIVHVHLDIKKNNGNRNLRLLMTVDQQKQECINEWNIQEPDHEQCDQMDGGYLWIPILRKCVATDRRIHYSMRVGRAGGGRGGGGGGSVGRSTGSRSWFSNRRNGIVDYRSNISTILMVSMLSLLLILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDS1</accession>
    <name>A0A922LDS1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDS1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036863021" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9530245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="9091" checksum="2A121898720F6C50" modified="2023-02-22" version="1">MNNGNQNFFLLLAAIASTLGQKHLYNLFTTTIHDCNISRYFLKKIYSIKLLQQQQLQQQQQQQQQQRTLITNHQSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HFM0</accession>
    <name>A0A922HFM0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015908</name>
        <name evidence="1" type="ORF">HUG17_3879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HFM0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7639846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="235" mass="27245" checksum="5A28F59B7D796480" modified="2023-02-22" version="1">MMTSKRELANRLDRLENRFESLCSLMNNLLKITDNKDDGNLSSIRQMTSNQLRNRFGEWLFNDSGRWSQINRIIDRPSSTATTISIPMARVAISGGNDDQDQGYKSLSPNIESQRQPTIQQEPIAHNPHHQNVHDGDGNNDQRKKHIIYQLIFETIEPMILAGFLSSDMMLLFNNPLFTIIRTRPEKMIIFLECQHTVQDFLAHCHYDPSKGCWQLSVRNLPPIKITLERSIYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKY2</accession>
    <name>A0A922HKY2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stk17bp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">STK17B</name>
        <name evidence="8" type="ORF">DERF_015987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKY2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF12">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9491255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="656" mass="74579" checksum="21DB0BB6015A1F4E" modified="2023-02-22" version="1">MDYVDDDDDDLGKFACVRRVKHRQTGRQYAAKIMKRRRLRHGDVTDEILHEIRVLLSAADSDRIVRLYEVFETRLDFTLILELAEGGELQKVLDDEESIDERQCRRLIRQIIEGIRYLHQKHIAHLDIKPQNILLTDALPNGDVKLCDFGISRMIEDHCEVREIMGTVDYMPPEILQYEPISLASDLWSLGIVTYVLLSGHSPFGGDDKQQTYSNITSSDLEFPDKLFSHITDDAKNFIRKLLNRDPKKRLNCDECLQHPWLLLDNNNMCETSSINDLKHTIDSNNQTSDLDDEEEDDDKHSDDDDDDDDDEDLAMAKSRSTSDSKSSSMTLSSIKQQNVVEKDSLLPSSNCDSGLGENICDTMLTNDDITKANNNKMDSCQNVQIDNNVTNQAIESMNSGQSSNDNVVDDDKENQIPPQPEQNLLSPFIMNTKYHHKRLSSDIFPDRKSIIAIVSNSLQSTSKKSTSESSMSSSSSTTISGDRTSRTLLVNVQNQQMMMMMSSKQENSVNSIINNDHSPPSTPSKKFYLSIDDYDINDDDNNHWKRRYSNLRSLSMERLNTSPLHNDDVYDNHISTIPLATVETHSITTSATMDSLFTKKINDNNTNPSLFQHHHQQTAMMTTTKTTIIHQTSLPMIKISTNNNNDVDDDDGYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMR3</accession>
    <name>A0A922HMR3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spatacsin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_015867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028103">
        <property type="entry name" value="Spatacsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028107">
        <property type="entry name" value="Spatacsin_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650:SF0">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14649">
        <property type="entry name" value="Spatacsin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spatacsin C-terminal" evidence="2">
        <location>
            <begin position="2128"/>
            <end position="2517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1722"/>
            <end position="1741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1724"/>
            <end position="1741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9491133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2671" mass="309126" checksum="5F1ADEB6A6B22273" modified="2023-02-22" version="1">MDFTALELGLRNRQLLQVKCFLRIQIETFRYFIKQDLCNSSSNEQAAALEKFFLHDWQNVVNKIVSFATIQMSGDYAAKIFSILLYRSLIYSCNQLIMTVSAIQIDNDDDDDDNSDDNVFIRSTDTTQSLRSSPISNTMASDTNTNENSLRLVKQRILLHLIKQINSMRDCLDNRIRLNNSLLPNEPLESTSLKIVRPKINDDSSDHDESLSTMLKTIEALLKTYGNAHRFQELFERSLQNNSIPLFVWAVKKFAQQSNSAYGEQLIHWDIIVERIVQYTAMKIGRPDSIVDDRLISEINSYLIQTGRPVFDILYALFIQTSDAIIRQKLLHIFAICLASHPEDDDPNVRIINSNVNFKQFQCQFGQYFRMLSIMDLYIFCFRPKISPVNDEEKLEIAFEWININDDDDDNGNIRLAKSFLLPILGELTQHSQMLNNWEEMTANNYNLIVFDPFRQHIFIEENFQSYINALSVWQYLIDNNDTKSLIKWIESDQIIQPYCDQIRPINLKMSIRMCEYLLRQSPTILLADIFVALISNPYFFNQHDFSDLMAKMLSFSDFLQIIGQTNILSSVNSCSSGNGCAILEKLLNKVIKLSQLVQHCIESRQYEFLFLLYNRYKIDFDVFFSSSSNIEESSSSSKQMLNVLNFMRDLCRSNGEVFEKSLFIHQFLVNDFSKPLKSIFSHSKSFDENVRFLLETFAAGSIDLDMILMIISFSSKYGFDEFFDALQQQEPDLVKSFVNKLATKYPLVHRASISHQESNASSSSSLNIYTFLQQAIPFVDINNVFQWQTNRCLSKPITNDSNSNHHNEMPHFSQKHLSELYGFKSNLNASFYLKNLRIIEAFLTFNKFLSSNEKSRDRHSINEKLSIKAIKKSTIIGYNNISDQSIVTTCLLFQSLIKSSLMPGKHKSSSNHRSSVLRETLDKNIFNECEKFRLHLALGRLIIEYAGDFLNLEGVQQQQNVLATLLRRSHFHSDRICSQKLLDLATVALERKYSSIQKPLTKFRRQQQQQQQQRQPPNRSLNVKFLLLFIETSNKFMTKNENDKDQIESLIPMIESSCNLLIECFEWKPLFMFAGHYSLKRPFGHFLNKCTNEDNWLVFVIFAQLYEIPKEDLQQILSQSNFNNQCIGEHLAKAFQSSRHVNVTSLSEAESRILRSKQTPDSSRNVLYSKLFKDKSIPIGSPPSVHIAPQSPPDNSTTVTESDSPENLSLFSSSMISGDLNSQKRSNVQVLFESKLQLQTASKDFLQLILDIYRNCVSFAHYHRVGPSSFSIEKSFQITLLYTSVSLSNPVLALLACSMNICDQRALPVDIKTTPSSSTSPIQSPKNGHNQQSSIKRSIDSSSAFDRIKYPSFACWLLASVSTASKQSFIDWYCQTNSLNPTTDSLIDCFIHWSPERLLRLINILTANDAQNYQKILDGFKMFDIQIPILYTLLEFHIEFLVMKDYYQTSDLLQRFQTLLAEYNEEEFIQNDSNKSMDGDDSNDDSDDYEWQLSDFFQRSWIEKCSLIMITNSLLIARQFELSILLSHYNFVRIQDSFSSEIHQYVPDIRRFYLFSQCLNKVPDYSLPIGPLLSIEANTNDESRYGEVLKNLILQLQQSGHFDAARNIINLLTIENTNEFIINEWMLKAKQAELESSNINNNNNIDISFWEDCWSQVVRIDPSMHSAFKVMERFVQQLEPDQLLIKCFVLLKCLLAIETILNDTINEIESIYPIINQTKDKQQQLQQPPDDNSTISSSNASSNNNVELIQDYFNFELSFWKSVVDCEMFIQKMDTSNDMKQIVDKNIITAWQDIWKDIVQYFTKSLLRKFILPKLTERYPHIGQNVENQRSKQQQNVQIDVNQYQSLNRVIGNLLDHFCYKKAIEVAKLFGYDHDDFEIIRTCDQIASGQLKDLSDASSSVQLKIKNQGENYSNGIGKFMKVTLIAGSNLTDDQRKIITMIETLASFTTIGEKFCEYILLHYKIACLLRKSYDELKDTDDEYSTTPCQLLEMLLLSNQIDESITVGHDVSSYSYQSFNEFNDSSMDQNQMSSLIDNYSETIMCAKEFIRFMGRIDDRLVNEEKIVDLLAEFVYNDVQRIVDRQFKDWDDPFNAQYTLFTEIELDRIQLEFNSARFSVLNRLLREPYLLGHKLLEWVKKSKTIFENAWNGFNHSDHTIDGQQPTVIHQKTEKEIRFILAKRKYYVQIVELYIRAHESFTAQCDVGGIALVLRKIRPLITQELRPARYFHLILRLLTGIGRYSEMIYCFDLFRECDRFELILSKRVQRTPQLRIALLNYLKNAEHIDELLPLVAIRFFLHREMADQHRNRAEKLLMETNFNNLHTSSSSSSSSLKTAMPIRSLTKKVSSTNSLSEMISTSPSLPTFKLTPSLLNMNNSNALKEQLEAIMFEFQEAEINYTKASSLANADYCSWRAQLIALQLYHFNKSKFTALHTDISTTVPILINLDMNRVRDFINQCNHYYEALIVAKSYPDVNIEWADPFFNNAIVNNNVQYAAQFLDNYEISVSFLEKVIKRFELFSTLFRQQQQQHQQQTIIKSSSNSQIAGQLFSSSSSSSSSPLPASFISSLSQIRSEMELQKIFLILEQIMESILCDGVNTTAQTNDSNVESSTMKFASTSFLKINLHDRYRLARRLNSRRILRHLMALNRENSAYLLDWIAKSNQNQCVNNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN47</accession>
    <name>A0A922HN47_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_013781</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000933">
        <property type="entry name" value="ABC transporter A family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3012"/>
            <end position="3033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3054"/>
            <end position="3078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3084"/>
            <end position="3104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3111"/>
            <end position="3135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3189"/>
            <end position="3210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="3809"/>
            <end position="3832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="4054"/>
            <end position="4075"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="4095"/>
            <end position="4122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="4134"/>
            <end position="4155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="4167"/>
            <end position="4187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="4253"/>
            <end position="4270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="3379"/>
            <end position="3616"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="4362"/>
            <end position="4598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="3757"/>
            <end position="3777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4323"/>
            <end position="4357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4682"/>
            <end position="4708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="4897"/>
            <end position="4927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="4340"/>
            <end position="4357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="4898"/>
            <end position="4927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9497826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="4927" mass="565805" checksum="84A55537E2076CD2" modified="2023-02-22" version="1">[encoded data, 4927 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNK1</accession>
    <name>A0A922HNK1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9496970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNK1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9496970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="6830" checksum="07CF3652F883457C" modified="2023-02-22" version="1">MPEISKAVGVVTAQAADMYLSMAPLNHSDVINPREIEGTCKIVRPGVKSKSALALLHLTLGPDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNT4</accession>
    <name>A0A922HNT4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNT4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7762" checksum="44E504698B22FAF7" modified="2023-02-22" version="1">MKIVTVIQTNLHHHHLTNLIIIISDQPLHWCPCGPPIMSNKNNNNKLKLKFNPLLSPEILVISIQHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP06</accession>
    <name>A0A922HP06_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_014983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP06"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="755"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="794"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="155"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9494288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="872" mass="100614" checksum="EF41A5B64CD02A6A" modified="2023-02-22" version="1">MNLKKILCPISSSSSSLSLNKHFLLAIFILLSSSSLLLLSHCQSINNYARHYRRFKHDTEPPPPPPSSSSPLTIDSTDSGFPKIDPKELLQVKVINKSVNYYKTQLLRVRTSLQDQLKEFINGLKAIRDQAQFGPELQEKMNETFLQFIQDLEISPYCLASFNHLLLEMKERRLWPLKFIDAMEFLPSGLLEGVMSMFGVYEECINIESPMVKWNDIRGKYCLAKVHLPFLNPLFPEFDVHDDNDLSRNHELKSIKDLYTYHGRKSLYNRINRDFDHSNNKFKILQMLNMFNGSYLRIGLCFPSTCSSFELERAINKFLQPISNPIRIEIEEECSYKGQEIELDNHQRMAIFILVGLCLLVGACTGFEYYLRNFRDPNEINKNQYNSYLLTFSALSNTRYLLGHADMATEDEKRLCSIDSITLFFVIMEFVGRSYVLPIFYGMINIKRALNGLTDQYFTAKKFFFIRGSSFAVCTYVLASSIILAYNICGRKSQIKPSILNYVKFILNRYLSIIRRLIGPILLIYLMPLFGDGPTWHYFSPLYVEPCKHNLWKTLLLINNFESSFDKVCLIPSTVFSALFYMSLAAPFILYTLNHKYFGYIVFIMLIILGTIISVIPKIVYNLPVTPYEISSISSVAEAKLSFIHYYSSTDQLIVVFAIGLFVGYLIRCKPKINLGKRAANIALWIGMLALPIISSQWNDTFKPLKGNFSQFNFISWFLLSKIMWCFGFGWIIYTCNTGRANTFNQAITMSLIRPLGKLAFGAYLNHITILSFRQLTKKQTSPLTNVEILTNDISDIVIAFTVAYIFYILIERPFYYWIKMILNIENDTNNDEQQTAVKRFSMSDLENGKLHGDHGEFDLKPLNDSNYSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPF7</accession>
    <name>A0A922HPF7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPF7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="472" mass="48182" checksum="1DF6B95019FEE58A" modified="2023-02-22" version="1">MCGAHVLFGSSLSTTTIGGNTNISGQSATTNYILTSHQQHLPTTIKTFTVGSTTTTTTASTITTTTTTSGTSQQQHFIAVSSNDSSTTIKLLPTSAGTIAIQQQQQQQHQHQQQQSGQHQGTISSINLSQNAQITHTPKGHIIISGNSGGGGGGVGPNSTTPTLLHQVVSHNNQSGTTTTTNPNQTLTFAIRAAGQLSSSSSTSSSSSTTSSSQSNTVHLSTLTLKNPSTSSSSSTTTTSSGGGGGGVGIQQVTVPNTSQTSALVAALSQSSSSSSNIGDQHQQQPGTTTVTANNAAILRTLASSNVSAKAIPIVLMQSSNPQNSNIIAQTTSGTAVSLINIGQHTAAIASNNQQQPFPRPIVSNKITTATQTSGATLGSILSAAAKQADSQQQQQQQQQQQYSNTTTTLSSPSTNQTTTTTTISTIAKPKESPLIEALMSSSKSSSSSSTTTTTTTSQPKDSKITDKDSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ30</accession>
    <name>A0A922HQ30_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CORO1C</name>
        <name evidence="11" type="ORF">DERF_012709</name>
        <name evidence="10" type="ORF">HUG17_8713</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ30"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="9">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="412"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7637609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9501900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="508" mass="56365" checksum="1FE395DF46C73F98" modified="2023-02-22" version="1">MASRGIVRTSKFRHVFGQAFKRENCYDNIRISKNSWDGNFCAVNSKFVAIVIEAAGGGAFLVLPLKQPGRVDINHPLVAGHKGPVLDIAWCPFNDNIIASSSEDTTVKVWQIPDHGLSRTLTDPVVDLVGHQRRVGFLAWHPSANNVLLSAGADCKIIIWNVGTGEILSAISLPDLIFHVSWCWNGSRIVTTSKDKKIRIYDPRTGDMEQEGEGHEGAKPQRAIYLRDDLIFTTGFSKMSERQYSLRSESDLKPIVLETLDTSNGVLYPFYDPDVNLLYLCAKGDSNIRYFEITDEPPFVHYINTYQSSEPQRGIGYMPKRGCDVHNNEIARLFKLHSKGLCEVISFTVPRKSELFQDDLYPDTAGDEPALTAEQWINGEDAEPILVSLKEGYQSTKKQDLKVVKKKSNILDTKPASKRSTADGESSAVTGSSGGGDSLDALLSSLPPPGMTPEQLQKFEELANEVHKLKAIVLKHEIRLRDTEKALAAHNITLDTDESSRTNNGETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQD2</accession>
    <name>A0A922HQD2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ELMO domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ELMOD1</name>
        <name evidence="2" type="ORF">DERF_013738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQD2"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF51">
        <property type="entry name" value="LD01482P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="145"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="317" mass="36992" checksum="20214715FB50DF34" modified="2023-02-22" version="1">MYIIGQLYNLLLTTIYFFFRKLLKGFLRKTTGLCELQRICYSADYSNAYRSKSVEQSLKLSKSPVLQKIDTELTGIALADQLVNRWEIVEKAVEATLVTKCINTNIHVDFTQPYRICLVQIYGYRQLIARLDRLRAIAFDSDNKSHRKLLETLWENLCPDRKLDGLISKQWTEIGFQGNDPSTDFRGMGLLSLENLVFFATVFGEYARNILSHSLHPTYGYPFAAVGINITHLALNLLRMNHLQTHLFNSETRLYVIEDFHKIYAYLFVSFDKLWIRSKPSSVMEFSHIRDKFEAAVIEKLNDDRSMFHWDPYLETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQN5</accession>
    <name>A0A922HQN5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DFP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQN5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43888" checksum="676475F67DFF1234" modified="2023-02-22" version="1">MNGQFIANAHITSPSNRIREKINKSNNNNQPLSSRKPSSSSSAARMDFAIKSAHGSRNGIGIGGGGLIQSVYNEFQNSDGGGIKSFVTGNSRKNDFHGDRKIDQKTLNKIKEIINAAVKTRFSMETKEADFDEDDYDQTPQVIEIGGSELPLEIHFKSSSSRINIKQSHETDEGQTIGPMKTNSKPMRIIHENYKPVIAEIREIITPYRKVFQEIQPVMEEIHTVVTQGKKRKKIKPGHRINDGGGTKGGSGSSSNAGGGLKGGSGGRQKQQRPSSSSLEENIRQVLERMNERSIQKEQFEQQTVEDNLEQQQQQQLEQNDEFEQQQQVENDRFSESPESQQQQQQQQQQVEIDDNDDEDSIYKVRQQSSSRNNAVGSRKGYDRRKKRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQU7</accession>
    <name>A0A922HQU7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQU7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="658" mass="75645" checksum="663B51949D748F56" modified="2023-02-22" version="1">MAASFILAMMSSFNLKYDYKTCVDLQRIYINRFESIYNRCKRKNFSNRNDKRYFLTLVHDIRKLHQILLCQFNVTSDFVQNRFESKVNELIQLYDLKLLDYDAWVDDGNHYGGGNHAGDDDNNVTDSTSKERTSISNHFGQLEPMVSKKELLELFRKLTRDTNRKGHCPACFYIGYRRYHTISRCKSIELAYEVYKQNENVLLSNKTLSDSYSDFDNVSDYDGDTLLFVNSGRNQTPSKILHPKPIIAHVGNKFKHNSIANQSESLTKSMDELAISNCLNTDWKAGINRSLSSPMISIDSSTIMVNLISKCKNQMEPSIKAMLNYDFNANYILRSFLDNLKNNFNYGDIKFDDFPKDISKRIIYKRIGIISINVGIGLFHESIEFIVLDGDKKRLNDNGFNDIFRNLHRFGMVISCEELKKFLINISKNTSSYNIDLKQSVKMIDYCFKNLVNANGCTVTIPSFIPSLLPQTISNDTEEMKEIVLGSGIHFKVKPMNPISNPWMNKLLRARILAPIIHQLDHVSQSMPIQINVKNVPIETDITAISTAYCIDPNIKIYYHFETAIADGLVSIESQENVAKYDNVIIYLIVGEFPSTSLQKLDNNNEQCDATTHRSLLFKFQPSNFIIIEKINTFDDCDESRELLIANYIRINVKPKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HR50</accession>
    <name>A0A922HR50_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HR50"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="386" mass="43920" checksum="DD9A72E8D6BEE7A9" modified="2023-02-22" version="1">MRFWDFPMSFGRGSTCLCQRENYPESKTHEILDLSGINLKELGVLKNVYRTCALIQLNDISISNIVRHRTYSMISKCGMLATLNPTLTKNSNFPFENLYNRYLGVINEFNCSESQRENYKKVFDNKQMEFEEINLIEPTSQNNLVNHLIEYIYKKCYNPRQANILIKAVNNITSTTTLTKSLKDNLLDLALSYKNHSQPSLTEFYQKINFCSTSEDCRDLLSIIAGQMGLEPNMKTFEMLSPTSPENITTAAGYGACTEQIPDSPISTDSTCVHHTQTGTVNAGSPSTSATMAIRSTGTKDIARKALPEDSRSLLYIYSNENDNSYVSESLEEDRISEENCWLELKFTERCGDRNRVIWHSKQIASKDGPTIIDIRQNSIWPSNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRB5</accession>
    <name>A0A922HRB5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_013966</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRB5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000065">
        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037111732" description="EGF-like domain-containing protein" evidence="15">
        <location>
            <begin position="18"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="995"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="954"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="963"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9498041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1089" mass="125449" checksum="35AA7F75D8CD420C" modified="2023-02-22" version="1">MMARLLIWLLFLPLISFESCSSQACGDNFFDCGNGHCLAKFFVCDGDNDCSNYKDELYCNSSENKTSDDDQHRHLPCPLNEFACNDAVNNCVPQRWVCDGQSECSNNADEANCSKSSIDCLGDFQCGSLECIPPKWRCDGVNDCLDHSDEQNCTTINDADNDLICDKLHDRYRCQSNGLCIDYSRVCDGQRDCPNGDDEQQNCHAEKCHNKKCSHICLIDEHSKQALCSCPPGYELIDGHYCRDYDECMQQKQHNLCSHKCINLVGSYRCECFGGYHLIDNRTCVVDTESGSRISPVLYFSTGNDIHGYDTRRKIIFPVLTLNDYDPTTIIALDLSIADEYPLLLHDIKSQIEGISIDWLAKHIYMTEANRERIVVCHTESLICTTLIENLPSPRGIVAVRSRYRLYWTQWHDNNGGIYESRLDGSQVTKLFTDVAWPNDIVYESETNRLYWCDGKTGSIEYYDFDIEMRRVVHEDFIRQPYSMIVFEDTLYWTDWIAKKLFACQKIRCHEQVNIFTPTISKRRGLYGLTMYHPLRQQQQTTKSEMIDPCVRHHHRNPCSHLCLSRTNETFTCLCPDHMYLSNDHRTCLSRSDDFLIISTGYRLYKFYPDSASTEPFEMITMTPMFLISDLAYNHERYEFYLYDRLKDRIVVAKMQPDLVYRTIVDEDIANVFGLTYEINSDNLYWVDMIKGTMEAVNIQKGYRAILNDKLEQPVSMAINALTKTIFVGLKSKSAQILMLTMDGQVKRSLLRSKQGFPFALVAYPFENELIWGDPVFEKIDFIHLDHSRYEHHGPEKLVEKHVGTVQSMAILNDTLFWTNGDTPRLYWTNLTSAMKMIESKKVPHSNLDNDVLKIVSGFKHIPIYDYCRTNNSCHHICLIGANGPVCRCNIGFESQDNGHTCVRKIHSLDTKITRPIVHAINLEDIFDFFLNKQKDQMFDTWINVDANTTVANTTTDIDQNEENQTTKSDSQSSSLPQTNDQSNESSNFFKRNSIYLWFIAVCMLGVSLLLCVKLNLLPIARMNSITDLACRRRRHRETATDNNVDEENGNKNIRTGQVRFFSNPNYQMGQYGQLKNNNNNLDNDLLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRU1</accession>
    <name>A0A922HRU1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRU1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="149" mass="17617" checksum="0C2CD5F631FFC0EC" modified="2023-02-22" version="1">MSSKFTNVVIIHIFSFVLLLKIEKFSLLLLPFVNFGSFQGLCYNVSINKANVNENNHDPRNNYYIYSSSINSSGEPFFSGRIWTKRQRKIPTIISIVFHRNNDISMLLWCCCCQRRYRKKNVIDLNDFIPIPVQYGRIIIFFFIFENIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS12</accession>
    <name>A0A922HS12_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS12"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="6749" checksum="7E35D76C566C6F0D" modified="2023-02-22" version="1">MTAMATAISIKLATNCLQIMGAKPSKPGDVLLLNLVMAFISSRSVTGWNGVSSLRWILDQLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSM7</accession>
    <name>A0A922HSM7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromodomain associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_011291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSM7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06847">
        <property type="entry name" value="HFD_SUPT7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039460">
        <property type="entry name" value="SUPT7L/Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28598">
        <property type="entry name" value="STAGA COMPLEX 65 SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28598:SF1">
        <property type="entry name" value="STAGA COMPLEX 65 SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="5">
        <location>
            <begin position="105"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9506565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="217" mass="25128" checksum="8A2CEF7CE3190219" modified="2023-02-22" version="1">MDLWGEIEDSPIDTKSQQLLLNSTPKIVNPSEFELHDQQRFQANPLLVKHHSTDYIIGSSSSNEITSPFFETLKLLIAKEQQINDYKNVEQPKTTKSNHNSVAQSMRESIIMILTHVGFDLSHDLTIDLLVDVLEYYLKSFGKLLRSFTDSIDLQSPNDFYDIMDKTLHHMNVPNFESLRKFHEELVENYNRVKTENSFEENIQKMSCQGTKTAETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSN7</accession>
    <name>A0A922HSN7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSN7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="7511" checksum="CC4A130F8763EFFA" modified="2023-02-22" version="1">MFWNGAFYLTITNIEHREIDDNFVSDKNEWTTKKKLQRYPIEFLVVIDMDTLYQLIINRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSZ9</accession>
    <name>A0A922HSZ9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dCTP pyrophosphatase 1</fullName>
            <ecNumber evidence="1">3.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DCTPP1_2</name>
        <name evidence="3" type="ORF">DERF_011405</name>
        <name evidence="2" type="ORF">HUG17_10639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dCTP + H2O = dCMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="EC" id="3.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.12" evidence="1"/>
    <dbReference type="EMBL" id="SDOV01000006">
        <property type="protein sequence ID" value="KAH7640159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSZ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047840">
        <property type="term" value="F:dCTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006253">
        <property type="term" value="P:dCTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11537">
        <property type="entry name" value="NTP-PPase_RS21-C6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052555">
        <property type="entry name" value="dCTP_Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46523">
        <property type="entry name" value="DCTP PYROPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46523:SF1">
        <property type="entry name" value="DCTP PYROPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029826">
        <property type="entry name" value="UCP029826_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR029826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7640159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="113" mass="13373" checksum="2CB95812C3DA720D" modified="2023-02-22" version="1">MDQSIDSNKIDKSFHFSPLTLEQIRQMHDDFVMKRNWEQFHQPRNILLALIGELGEIAENFQWKPDSYCDNGLTKWTEKERNALADELSDVLIYLIRLSDRCRIDVSKTICKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU11</accession>
    <name>A0A922HU11_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU11"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="119" mass="13158" checksum="F0CDAB74F358A5B4" modified="2023-02-22" version="1">MFSLFNISSLANIVKERIETLEELIENTGTQQTTSTATAIGGGGSTILTTTALHSSSSLDNAGNLINRNILSQQKPYHHHQVQQQQQHQHHHHHQQQQQQPTPFSVSSVKRDSMVAGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV10</accession>
    <name>A0A922HV10_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV10"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="155" mass="18475" checksum="0A375CFE5E2B0F26" modified="2023-02-22" version="1">MVIINHFGVRNNDDDIDNNQDGHPIQQSMTTKMAIMNRHHPATLIDSPNMMIMSPQLQHHNFQHHQQQQRNITYNWCLLYKNDHGNDAEHYKFIGGYLFTDMVRCPMKHHVHHQVTLKFRYQSMILTLTFLKGLHWIEFSEQLIRFVPEILQSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV88</accession>
    <name>A0A922HV88_DERFA</name>
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        <submittedName>
            <fullName evidence="6">Tight junction protein ZO-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TJP2</name>
        <name evidence="6" type="ORF">DERF_011354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein localization to cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06727">
        <property type="entry name" value="PDZ1_ZO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06728">
        <property type="entry name" value="PDZ2_ZO1-like_ds"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ3_ZO1-like_domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd11859">
        <property type="entry name" value="SH3_ZO"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GK/Ca_channel_bsu"/>
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        <property type="entry name" value="Guanylate_kin-like_dom"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="PDZ"/>
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        <property type="entry name" value="PDZ_sf"/>
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        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
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        <property type="entry name" value="POLYCHAETOID, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13865">
        <property type="entry name" value="TIGHT JUNCTION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="327"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
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            <begin position="437"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="740"/>
            <end position="813"/>
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    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="5">
        <location>
            <begin position="1898"/>
            <end position="2033"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="16"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="1207"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1215"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1320"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1752"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1763"/>
            <end position="1776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9506630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2036" mass="227656" checksum="ECBD9AEA93E4BEDC" modified="2023-02-22" version="1">MFRRFYCKIFSSEQRSRRRTSSMMKKKRKTEPTRKKEKQSLSSSSSLLMKGSSKSGNVPTGHNSYRQSNSVTPLNKKRSSSSSSSRIKSRRDHHDDHLNANKNDEHSKRSRRTNSLPKSNDKSKNGSKTYDNKNDNGNHMFKHNVSNWLTNFNHLHSHTCQDGQVEKQNNIQTIIQSPKNRNPDNDQSNRGHGGHYIPSSLPSRNGGRESFIQVQNFGQQLWPHQERQVQQQRQQQQIVRPFGQIDANGYVKTTLTKSLGPPLPLSSWSLCHPEYNRRQQQPSINRSGLMVGRHKHQPLPFTSTTTNMDQSIPYSLGGERVGWEYHDITLSRVPVYGFGIAVSGGRDNPHFMNGDPSIAISDVLKAGPAEGKLLVNDRVISANGISLENVDYSQAIHVLRECGNTVNLLIKRRALISTMNSTHFSSVNDANNNNLIKITLTKNSKKEDLGIVLGCKIFVKEIVNRNLTTNGDKENHLQEGDVIQKINNTNVENLSLKEAKKLLDNCKDKLTLVVRRDMMINQNFLNENRNYINGHSRSNSGISNMFRQQHQHLTQKWPQNGYESSAQSPLPNTSLSNNNELANDNVNHGQSPYNSSSIATMANSRSTNGWSNQNLYVQPPTRMNDSSLINGNHDTTRNRELINGNIDHCEPSSTSSMNTSETVISPTAKLSYRPLPQKPTATTSSSSSIQLGETTESTNTNMVTTSSNVNSNPETVVDQEISLIPKTQINNEIRYIAFQKEGSVGIRLTGGNEVGIFVTAVQPGSPAYQQGLQVADKILKANNVDMKDFTREEAVLYLLRIKDRIELYVQNCKEEYENIVAKQKGDSFYIRVHFNYDSEGKGELSFHDGDVFHVVDTLFNGVVGSWFVYRLGRNNQEIQKGSIPNKSRADELATEQRLENRSKKSNSGTDDLSITETGSSRRSNFFKRRRSARRSKSLCRENWEDILFGDANSKFQAYERVALRHPGFVRPVIFFGPLADIAREKLLRDYPDKFESPQSMNSSNEESTKNSKLNNSGIVRLSAIKEIIEHGKHALLDITPSAVDRLNYAQFYPIVIFMRVENKSIVKELRNRSSTKNTVHRSSRKLFEQSIKLEKIWHHVFTSSITLTSGGDLWYKKLREIIDKQQTQNVWMSEFKPDESISDDFLFPMNSISRLSYASSPESDLDISMNDGKMDDDDDNENRDKDKDGGFLSSTSGGRLAKSSSDPSLAKIDPASTTAETMVSFETNTPKADETKSIENQSTMPIKNDQQSPSSPNNKQIPLHLLLKKELTKNNSFQKRMEQQQQIDNIPITEYPTLKLGDTQSMSLDRTAVGVNAESPLPPPPPFPPLPQPATSNSSKLAVEIPPRIDRNSKPSRFRSAHERLFGSSSSSKATQPAPPLPPPTSVASSVHNGSNGHQYDDSDYINTTVFEYATDKLQKIEQSVDQHMMEQKNSVLPRTTGSFINDPYKFTRSAAQSVQPKPSSLERTKKPLPPPLPAPANGKTESPGYLQHPTKTPPSPPPKPKLNNHSLQYQMNAMTLNDNRQQMLNNGSKPYMSTTNMMHDRNHQQGYGDYDNMPPLYPLKVPPKRALNTVATNSSEMSNGPPGYYQSLPHSSYHHGYPTSKDHSIHQRYSSHAETISNFINGTTTYNNTDMNGNLNMKDRTAYIDSMQGVKANKVAVHMDPSANHYNHSQPNYDNLCYPSSSGLYMNSTANYMPPPPPLQQQQPNDNTYLNFPFNVRTFENPVGYDHHGPMASSMMNDMNGHNGQPSPLPPPPPLPTYSRSNNPTPNIVQPIPQQARQSGLYLDLSSNRENRGSAFELYQRKPMDTSSARISTTTPGSPMFHGLPPPPPLLPVNDFNLANMYTNIDEINSSSQSSSITRFARGTGGGGDNNTFWNGNSNGSGAKSMDQSTVIATARGIFGSEGGSLVSAETGVSIIIPPHAIPEGVTQEIYFKVCEDNKLAPPLDRNLGETLLSPTVMCGPHGLRFNIPIELRLPHCAIVNPESWSFALKSSDINNGEPTGWRNISLNNECDRINANNFNEQFVSVLVDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV92</accession>
    <name>A0A922HV92_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV92"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9507094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="98" mass="9769" checksum="64823F7C39C16D59" modified="2023-02-22" version="1" fragment="single">MGIDGPKGEPGEKGDKGDKGESGLDVITTSKGVKRSVTRLRGGTLGYAELIAIKGLASMGLIATPRDILLMKGPPGPIGPMGPIGPPGPLGKDGLQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVV5</accession>
    <name>A0A922HVV5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVV5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="110" mass="12593" checksum="19E52C8009E151F2" modified="2023-02-22" version="1">MTKREYCQQQIKLWPTWQDTRTPYTSVHLNPNNTSVAQSREFSVQAPALGTTKRDIEFVRMTLEEVAPLVTLLMSLPKTNHSSLEVVLLYKMKVLDVQGLLDSETFTPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWC2</accession>
    <name>A0A922HWC2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010039</name>
        <name evidence="1" type="ORF">HUG17_0086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWC2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7644548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="109" mass="12824" checksum="173E6A4DD34CFB2A" modified="2023-02-22" version="1">MDPQLVYDELYRVLRNSTRVSIMASSLFIALQTEGMLNAENLRQLNLCKRAMDTINTRRLVLNNILDRSRIYDLNEQVTIMRQLLNDTWQLTVHVIQVIDEFLSEQTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWZ7</accession>
    <name>A0A922HWZ7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWZ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="78" mass="9655" checksum="4CC73E10D88E5BE1" modified="2023-02-22" version="1">MNFLVLQFIHRFDDQIKLHHHQSLSFYWAANSYKFIFTETFFFPFNSMKRCEKQQQQQQQQRQSPRNHDNETDDDPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXV1</accession>
    <name>A0A922HXV1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Proton-coupled zinc antiporter SLC30A9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Solute carrier family 30 member 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Zinc transporter 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">DERF_010064</name>
        <name evidence="24" type="ORF">HUG17_0103</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Derf</strain>
            <tissue evidence="25">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">JKM2019</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Derf</strain>
            <tissue evidence="25">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXV1"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21078">
        <property type="entry name" value="NTD_ZNT9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040177">
        <property type="entry name" value="SLC30A9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414">
        <property type="entry name" value="HUEL-CATION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13414:SF9">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="23">
        <location>
            <begin position="248"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAH7644565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAH9511616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="576" mass="65422" checksum="289DE565F4CEA33F" modified="2023-02-22" version="1">MTIISNLIMANNYRPTNHSTKMLMTIMLRSMIRRNMIMMNNNHQQFKRRSLFILNSCPFPSSSSSSSSRLVFQNNHQYRSFIVNTPSQQHYRLVNNYWLQLTRTLSNTTTGSKSEDIHVIPKVKTINTKERNKDLTLGRNFITTTRAMREYALDISDLVDLRKFQRRSPYNDEPPITVYLRKDVEAKALEVWKNWDCLNEELRRRKEKEETYSDSLLIVKKYNKDYRRLNTPQAKFRENIMRESGRVVMAAVIINGANFFLKLFAWLYTGSHSLFSEAIHSLADTCNQLLLAFGIRKSIQVPNKDHPYGYHPMRYISSLISGVAIFCTGTGLSIYHGIDGILHPEPIESYYWAYFILLGSLISEGGTLIIALNAARRSASLQGISLTQYILAGSDPTLNVVILEDFAAVLGVTIAAGCMGLTSYFNTPIFDACGSLAIGALLGVVASFVIYTNAGALVGKSIAPNRMGEINKFLESDGMVRAIHDVKATHMGNDMVRYKAEVDFDGRKLTRNYLDSIDLEVLYKEMLSVKTMDECEEFMLKHGENIVDLLGAEVDRIENELKAKHPEVRHVDLEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYC9</accession>
    <name>A0A922HYC9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYC9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="246" mass="28708" checksum="7BDC1F343C0BE00B" modified="2023-02-22" version="1">MHTPLMSSIHSDHQHCSNARYSDHQSLILAGGNWKLSQRNSINDFGRFNISLGNLSNNNNNNQLNGHQQHFSSTMTSMMASNGSIQQQPSSSSTTTTNTAMMTDQTKISHDLLDKYRTQVSYRVNEETDRQLKEIDQWLYKHLEQTQQQQQQQSPNRTNINNNNNNSSRLHLNQDIGSIRQQQQQQQQQNRLQQKGNKNNKRYIFINSKILQLTYCSFIFLISKLQFQWLAINKFTHTKCQFFIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYM4</accession>
    <name>A0A922HYM4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Lysosomal cobalamin transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LMBRD1</name>
        <name evidence="13" type="ORF">DERF_007789</name>
        <name evidence="12" type="ORF">HUG17_2114</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYM4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="9" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7646576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9517089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="529" mass="61544" checksum="199BCF0E5B0C8A9F" modified="2023-02-22" version="1">MYTVFPFENLAGILSSFLFALLFIILFSIYYVRKYSNHEDSIKTTNITAIVSLIIALLTCSLLPVDIFIVSSMKYPNGTFKEWASNVTEREHYENQILYTYYSLYSFIFMFVFLVIPFVYFYFEERESSIFDTSPLLNALKNTFIFVLLAAFFLLIGAFVPLRPTPDPNNNGSWIDKFKNLINVLEKNRGEDAMSMVLSILTAIGVTNVAIYTAFGMFSWPVSLIKGTKSARTQLQDIEDRHLNNSFNINSLREKLRTTGHLTEREMNRLRSLEEQERMTSLEESYVIEYRESYFYRLRFLFRPIQIFFGTIILLISILVWISLLITNVDKAFHSLGMHMGYALVNSTFPNPINFILSELQTVYPLDYILILILSFSLVMYTISGFKHIGIRFLCIKLYKIKPRKTAPQAILLLFALIMLAILGINVLFYSAFPQYATYGRQFYEDVSANQTLTKICTLDSPKDSCTMTRMSALLLRFFYKAWFFGAYYYWMMWTFLIVSLCSFIYVSLRPKQTVTQGLLENDFENEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYQ3</accession>
    <name>A0A922HYQ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYQ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9512111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="17" mass="2124" checksum="F08121FB4B4B5C67" modified="2023-02-22" version="1">MAYNNNNNNDNHHHYDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZB6</accession>
    <name>A0A922HZB6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_008125</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZB6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000177">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="15">
        <location>
            <begin position="178"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="16">
        <location>
            <begin position="434"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="699"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="699"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9517449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="817" mass="91881" checksum="7E819E9CF027C5BF" modified="2023-02-22" version="1">MNGDHIHMKCDHHSFSSICSIMHDYNIIKIDHSCDYIDFVACAEEYIGNIYRIALVSAFSGCLLFVGKIEEEEEAYTSRKKNKIHSSNEQTSFIHHHDDDDVTDKIFIGNNHHHHHSSFITKSSSLPNQPSLNGQNMSYSSSIILEAEDDHHHGRHQTNHNHHHHENGDTIIRSNRLVAAIDQGTSSSRFLVFSTETGELVTYHQIEIKKIYPNEGWVEQDPAEILSSVTRCIDVVAKKLPELGFQISDIRCVGVTNQRESTILWERTTGKALYNSIVWLDNRTSDLVETVIDRVPGRDMNWLKSKTGLPISTYFSALKIKWLIKNVAEVRRSMLAGTLMFGTIDSWLLWNLTGKHLTDVTNASRTLLMDLETLEWDAWLCDFFQDSNLDSTRNKAIQFNIQNGPLRSIPITGVIGDQNAALVGQKCLSIGQIKVTYGTGAFLMQNIGPGPLHGAYKNVPEEARHKLLTTVAFKLGDEMAWYALEGSIAIAGAAITWLRDNLELIDNYGQVEDLARMDSNSGGLYFVPAFQGLYAPYWDAYASGLIIGISQFTRKSHLVRATLEGVAYQTNDILCLMRNGLNYGIRVDGGMSSNDLLCQILSNVTGNLILRAKMAESTAFGAALVASHHCGLWERLLKADHNHQQLQINDDILATNFNNNNQSAMNNGKICNGNISNKLQPQQDSTFDHIKRQLSSFLSSSSSSSSTTTTTTTSLSPSSTLSSSSTSQPPKSTAQLLCEPINETMKLQYDLFRPELDEDQRQERIENWRAAVRRSRKWIRINEQKEQKRVEYLRLSTLPMTFFIISTLGLCILSRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0F6</accession>
    <name>A0A922I0F6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Ras1</name>
        <name evidence="16" type="ORF">DERF_008474</name>
        <name evidence="15" type="ORF">HUG17_2592</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Lipid-anchor</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0F6"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000096">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7638559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9517851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="187" mass="21161" checksum="E34F5956DD30CDBE" modified="2023-02-22" version="1">MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLLVFAVNSAKSFEDISTYREQIKRVKDAEDVPMVLVGNKCDLPVRSVYINGAAEVAKNYGIPFVETSAKTRMGVDEAFYSLVREIRKDRERRGRDKRKNQKSSKKCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0K6</accession>
    <name>A0A922I0K6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription initiation factor TFIID subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TAF3</name>
        <name evidence="11" type="ORF">DERF_006640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008537">
        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22916">
        <property type="entry name" value="HFD_TAF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15522">
        <property type="entry name" value="PHD_TAF3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.180">
        <property type="entry name" value="Proteasome activator pa28, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46452">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46452:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47216">
        <property type="entry name" value="Proteasome activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="924"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="1210"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="418"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="654"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="855"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1007"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1158"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="617"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="674"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="883"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1013"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1170"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9515866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1579" mass="180816" checksum="6AD9236E57C33392" modified="2023-02-22" version="1">MSSSLTFQQSILRAIVSKICHDVGWHSAHTSTLNVLSDLLNHYLRRLSMLAIDAANLAGRNEPTMDDMFMAFKYIAIDMNQLKDYVLNVESSPLEFSLPVYSLPNRPSRIFDQYDPNEERSEYYDEWLPSLNCTKYIESDSNEHTKSMISADENPIDLNSEKNDLQQNEGKLSETQNQTILDKNDNEQKTDKMEDEIETETADDEQKTKLVFKFSLGKSLEENQSNANQEKSAQNGTDNSNKIALFQSASANDLVNHLMSSKAYLRLLSNANSGSLLPNLENQETRKKLRFPDTQRLPNNHISRENSPEPGEPENADFSANNPLNAINNNIDLDINLKKLKKMPITKKPIKIGSLGLEEFGESVTPSIKVKEIRSNNKERVKKDVTEKISRLKKPKLDKPLNFKFTISSEDKIVASQDNDNLKTTTPVKKRQYKRKDKPIKENVERKPKKAAGRKSVQKQKASNSTDFVPSPLQNASLGSNLFPPKNSKNISDNSFNENEAAETLVSIFESKDVKKENDDSLSYISGIELDMDDSNSKLTSTSKKSSRPNTNNNNKRNKSANQRFKSAEVINSSGDSSSDDNMDVDKIPVSLLVNQSDINESLDNEIPTSNRKRHNSNSSLSSVYSNSSKSSRSTAMIDTGMDIDDSKLLGKAFNEEHHIKSKKPGEEKSKESSKHKKNKKHSKNKHRHGEEKQHKKHKKNRDKERDKDVAKIKEKDFKPKINIKFGQGPSDSNQDPIKLDTLNQSVNKQKVSMKEFDEAKLVDFKESSLIINKIEKKSATKSKKAETEDIHNELVFIKDTTIKTKESKTKKNPIISVATSLFANDSIVNTPSNNKASKSKDVLVKEGKKVKNKDLDLAKGNEELPLPPPSSSSSLKHKKEKSIRDLKKDKDSPHVISKKDENQACTVVSETINVTSETIDNKLWICPICLKPDDGTPMIGCDTCDQWHHYYCLGIQHDPNPGGPWFCPRCFEKQKKKLEKFQKKQEKLAKAKNEEDFVTITVTTNIDETSKPKRPVGRPRKHPPLNLSTPQDSGLTITPIDPTPSLSTTSSSMKYDHNFIKEQQRQSYLTSMEMIMNQAASAGGDVGSIIEKPTQKKEICPKCQSVENLSVNMIGCDSCDQWFHWPCVGINTAPSPDSSWFCAKCIKKKSSKRLWTELDSGSDSEQQSSKHRRKMHHHQKQLSSSRAKSHLEDQIHDDSIVEIQTDSKQSICGTCKQHTKNDLNEEWIACDICDVWYHFVCENIIKAPEKNEHWFCRHCIKKQRNIENQIHRIRRSNIRKLPTVPLDSSNLNENKEKMINDSIECVQNEIPKTLIQINEFYNEIIKFIDDNYDKQLTKNDYENIRNKLQNKLEKLWPFECEQQQQQQQSESKQVSNKTLSCAEKRHPYSQCVRHVNNLHHHCYNRYSFWETINIVPEILSNTTISNEYIVRFSEKFRSIIVDLTEKLLKINIGFSFLVPKTEDNEDNDISIKVLDKVLALTSFECSIDFNEIFNERARLLKTINQHPHSEECYFMMQEYDHETCLQIQHELQDIMTQCYCLYDIIIKNFDKIIKTKKSFKRNDDNNDVYNDNHSTLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I179</accession>
    <name>A0A922I179_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHF complex subunit HOOK-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_004327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I179"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="871"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9520627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1111" mass="127305" checksum="A11AD519DFCF52E3" modified="2023-02-22" version="1">MPDVLNSNVSSSSSSSNNLSSTMINNNHSHNNNNNNHHHHHHHHHHPMSSLSTTDEYSSRYSSLQDTESLKSAILDSFRMHWIQAWSIMECKILNDITIDDLSSIVNHIEQMISLLVEENVNDVRTAASMSDIKTFEHTTTSSENNSHHSCGQHNLNPNNNNNNSIIIESSSTSSSSSSSLSPLLEFLSSESILEKIFQWSEMSGEWKNAMYLEQLKLYDLLISELCQTDIILFKQSFFQPLIYLLDSLSTFLMSNYTTINNYVVEIEKRLVILLNTLCVIISQNNRLLNLFIINGKFYSTKINNSNRKLSLNDMYDDDMTVTINHQNSHMPKQQSSHLDSYCDKQNKTNEHTDKIDNDYDNQQDDNFENVSFPLFSLLIQFVHRDGPIGQQARDAILLCLAMSRHDERLAYYVANKTDFCPILATGLSGHFSSLPRVLIAANNDNHQPLSGNNNNNNNKNNNNNEQYQSYQFKHELLSNSKEIDHFLKCLDFCNAVVQMSHPIIQVQLLKFTFNGFLISVIGPALHQNTLDEIITTTAYLDLFIRTTSEPKLIRIFLEFLCFEVYDNNFIISTLINRITAKSKLSLVTLIFFKTLLDLNCEDLLYELIFKHLMRGRHLKKESHHDDNLDYSSSKHYAQNQSYRSYQKNWLAISAQKLLSTSISYYLNSLCPHQAAAVNIEIESISSFDSNISNNCKCHSGYFLNYLNYLNDARQNLEQCHLATKTWRNSYHEPCHLLNEVQDENIIFCTIDRNNLNGDNNNNNNDNNDDHNHDDCGHQQQSTTTMAMMDEEIIDINDIITQNTLLAKFSPGFKMKNCYYDLKKKKISYKIETNKPSFFGMMNIISNNIKSSNNNNNNNNRGNDWSEPPPIGSFLSILFMKFEKFFENEVITNLHLTGLLTRLCHFPHKLLLSLLFDETLSRTKNVPCFLHLIQKLSLEAQNYCDEIPDFETVFQAAKSNLQSMPLGEVECSLLLGSGAGGVTNIRSSNSSLSKSNETNEKGSQHKAFGMLKNFFFRSTNSSSSTSTIVSRRPSNASIVSSTGQMLEVVPGGIRFINQTLLQQQRELREQRDQSQNVNRFNQLVYNIIVFDEFLMELSAILIEHSLRYIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I190</accession>
    <name>A0A922I190_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_007408</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I190"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9516683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="310" mass="35052" checksum="21BF71D06E77E089" modified="2023-02-22" version="1">MAQEMKMTKKTSNRFKSFLFILYHVFKNFILFFVPNRLMPKNFKNVNDQCILITGGGSGIGQLMVMKFLKLGAKVIIWDVNVDNLDRTRQMAKGYDEKLFCYRIDLCQKDSIYETAKQVQNDVGPVDILINNAGVVTGKNILDLSDEQIQRTMNVNVISHFFTIRAFLPRMIERKSGHIVTIASLAGELGVALLTDYCASKFAAIGMEQSLHFELAKANLDSQIKTTIVKPWLITTGMFSGAHSGLIPMFSPEYVAQKIVEAILLEKSVLVLPWYLEYMGILLKIFPSKCLIPIYDFLGGFESMDNFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2G0</accession>
    <name>A0A922I2G0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_004930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2G0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF158">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="571"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="444"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="502"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9521257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="626" mass="69628" checksum="71D7116E8501E9E2" modified="2023-02-22" version="1">MMIDPMWQDIESVLLLGQQQQQQQQQAPPAPPPPPPSLQPQQQDQITSSSSSSSSNDHHHHHHHHHDNNNNNQQQSPTSTNGQCIINNNNNNANNNNNNCSNGHDSLTNNNNDETIINGQSITQINMDKNGDKLESINNSNNNQTNSLKTKQLDLTEMIINEYGGHFYNGITAINNGDVNDNDNDNDDDDNNNNADGQRCSTMVVNPTVTSIQSILPVPPYSSPTNSTKISITEMMPSVTLSPNSIISSSSSSSSSSSSSSSSSSPPMINSIKNVNQQYSNANKTMSVANGGDGVMPILHQQLSNKFVTTTNKTIISHQQINNNNNQVSYSKSSSLSSNGQTSSAWNNNNNNVRENQIDNFYYQNTTTANYNDNGYCHTNGTDNNGYHSRFNQNVSSLSVMSPPASPADQKSLIQMHLHKQQQQPQPPNSDTNQTYQFLSTSAWSMTNSQQQQQQQQQQQQQTMLTLQSTNSSISQPPNNCIVTNDNNNEDIICNGQLMQHSSNHTHSLSQQHQHQHQSQKSQTNNSNNSVNSRQKKVTTHTCSHPGCTKTYTKSSHLKAHLRTHTGEKPYQCSWKGCGWKFARSDELTRHFRKHTGDRPFQCQLCERAFSRSDHLALHMKRHAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I336</accession>
    <name>A0A922I336_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Strictosidine synthase/gluconolaconase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_004790</name>
        <name evidence="3" type="ORF">HUG17_7744</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I336"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF88">
        <property type="entry name" value="ADIPOCYTE PLASMA MEMBRANE-ASSOCIATED PROTEIN HEMOMUCIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="91"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7640277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9521116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="438" mass="49911" checksum="152EF966EB127E85" modified="2023-02-22" version="1">MAFQIKDLFSLLYKTTFDILFYTTVISIIFGLLPDQFFNDFPIIPMKYDNEHFYKGLYGFEWNDHLVSKAKMIAINQVHGPESLADIGDYIYTGILGGRIVRIHKQTEQIDEIVRYNNSKECQHEKLKAGNCGRFLGLREQGDNLYVLEASTGIYRVDLRKGELIHLSKHLIPENESAIINDLVFDPKHSEIVYITVSSSKWSLDRIAWSIVDHDKSGYVLALNLSTGQSHRIADGFALANGIEITADQKYLLICQTTDFSILKVDLDNVRKIFLSKQSALKADQLEIFGQRLPGEVDNIRLDKSTGDLLIGMFTVRPYSKVLRDYLAQWPFIRKSFARTAYALYLLLDYIDAKVISNAAIEQLRDDLYTGHIVYKALPQRDGAVIRLDSKTGHIKQIFGSSKFFGISEAIIDTQGDLYYGSFRNSFIGRISKNDHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3G0</accession>
    <name>A0A922I3G0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_007999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3G0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="155" mass="16896" checksum="E0057AA636CEE231" modified="2023-02-22" version="1">MEKTSNTTTWTISPSDQISPVSLIIIILSSLVIFISVCNLSLIFAKLTCQRHTSSSSSSSSSSSSQMPIKTTTNPSANVPPLIMTTTMTGAALTSTASSQQQQNLPSNSISQQQQQQQLKRMKSQSQSRSFRTLDQPTGKSLSIKLIKQIWKTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3L1</accession>
    <name>A0A922I3L1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3L1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038078758" evidence="1">
        <location>
            <begin position="18"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8674" checksum="974299BB8A7B58C1" modified="2023-02-22" version="1">MLELLTIFSYFLLLVFHKEDICFNVLLSIHRSIWYYNKPLGYIQNYYDYYELQSIEHDDCQIDNCHDGVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3T3</accession>
    <name>A0A922I3T3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3T3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7161" checksum="12EDB95B20CE1F75" modified="2023-02-22" version="1">MDEIILGASIEYSNNENNDDHDGQNFINSQKDEIQKQHKINDLKMTAENTNESQLVESFQMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I447</accession>
    <name>A0A922I447_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I447"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8053" checksum="5FAEBDE7802B5B79" modified="2023-02-22" version="1">MLSASNLLELSFTVLRKSDDCRIGSVSFINNNNNNNNNQMMKTTTRNIDDKLKQFFSPHFQHVSSLSSLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4V3</accession>
    <name>A0A922I4V3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4V3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="78" mass="9151" checksum="13543C4C55B95E56" modified="2023-02-22" version="1">MQLQKLYNEESSFVLKCETMKNKMSFEMIKFKLTLIHYKCNPFDSTKINGMDGLQIYILCHSSAFIRNNPISFYSIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I704</accession>
    <name>A0A922I704_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_006139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I704"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9522575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="673" mass="77520" checksum="ADEEBD999985E06B" modified="2023-02-22" version="1">MSTRISETTTTTTTAIFDTTMLMILSNDTNDVDNGEQSLSLLSSDTSSSISMMNNSNSYNQPYDNDDLQHHQQQQQQQSNIYYKIINILKEIIIDLFEELDPIAIGLIVAAIMIVIIGIMAIICQYRTWRKSQLMMISKNIDTNSWLEYKLDRTKLAKHDSFRFSSNNINNNMVADDDNNDGSRSSIISSSLPLPSPTSSSSCYYHDEYKQHKRLIKSWCWNKTLAKDNRKQSAMKKQQPKWPINSYYHQQHQHHRHSSSLSSSTIGLFEYHHPNDCMIRSSNGYCNQNKMMQFSTTKNNHPHPYHYRNNFKASNLLLYNNNNISNCNNYLEHPYNIYGNMVAISKSLPKILPPSSSPIFIVDIPTKSLNASDMNKNKMTKMNNKKKKKKMKTNIKNDKKMMKKSKPSSSLLLFGKKRYYPNSNNNNNNQTDLQPFFSIKSSSLSTSSSTTRSNKAAISIVERTNNNHRCSLLNDHRDYEIQTVEMNLTGSDDGDESIDGDDHDHRQQQQKREKLPSIEHNHQLSSSSTSSSSSTSAMNNRQRQRKDPNRFSNNKSMSNLQSMKNNSFIQLNDRNHSATVTAKNPLYMEHNTSSDEIIMDNNNVTKFDGHQIPIFRSQSYHNITTPCINAIAKNQRLINEIDYYPRRSCCSTFQKPLLTDNDHQNNHDHHHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I757</accession>
    <name>A0A922I757_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Platelet-derived growth factor (PDGF) family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_006271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I757"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000072">
        <property type="entry name" value="PDGF/VEGF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21719">
        <property type="entry name" value="FI06402P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21719:SF1">
        <property type="entry name" value="FI06402P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00341">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50278">
        <property type="entry name" value="PDGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Platelet-derived growth factor (PDGF) family profile" evidence="3">
        <location>
            <begin position="128"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9522707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="310" mass="35025" checksum="9114324C8338B9BD" modified="2023-02-22" version="1">MVIQLFKRKSISSAAIMTKVANKYMAKTRTTMTMTGMITLAGIISFIISHTISSLTMIIIIGNLFTSSLYSLRPFVICDIIHDDNNNHANSDQYQYQRLIINQPNSNESLLASEHYNRVLKYAKCQYPMAKVVNIQNELQNPSATKKYIPHCTILHYCGEHTGCCRLETEHCIAKTIEMVRLYFWTIEITARGHKKGIEVIMMKNHTECMCAPINQKSSSSPSSSSSSLSINHHGANRSSSSSYHSNHHQHRFNPTTLRFEPVTTSLLLSSYPTTLLPTTITTTTTTTMKKQRKKPIVDRSKSIRTNNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I776</accession>
    <name>A0A922I776_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_004963</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I776"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="855"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1212"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="552"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="963"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="908"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="972"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="987"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9521294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1265" mass="145701" checksum="12667D55B37328F4" modified="2023-02-22" version="1">MMIKLLLKIIFITFLIIIYGLFVNFAESCLYDIVNYGSLYPDRAFVEVGKELSFDCKLEKEFVDNGTIDIARVFFDHNEIAIDTRFITRIDPYTVRLSIKNTSLDDIGNYSCKFNNTRGETKSICYSDDKPLNVDNFKCIYYYREKLLCSWTKPNNTILTVYSLYHYYEGILSEEKPCGHNYSDDYKQYCFWNISHEVSLHNARYYLLLKGENQLGTNEQSFEYDQTSITQLPPPRMKPKSEQFVNGRLQWIPPKSLLVDEKLKNMLQYRISVIDIYNNTLRMIDYNPHKHDGKSMSNNVSLKIKDLRPFTHYRFNISCKIDDSQNPYWSDMISVDILTEPKIPETSPQILNQSFMIDSMAEQRKVVIYWQQLANELKNGPDFEYFVSYSAENEQDWKNQTTLYPNLTLTLNNVSYLFRIYSKNSIGLSNNYSLFILPATKKILWNNDSNVLASMINVSMFPNGDYELDWTSINDSFIKDYTLFWCLAINDHGQCLDQIHWETKYKKHGHLRLPDLPDTHHVYKFGIAYNSHDQQTTGIIWAKCLANLKTKKIDGISFSVSNIKASSVVVNWKLACEAQRSLIDEFEISYCGPQSCKSENADKNENQFTLARLEPNTKYRITVGLPSLPKNNEIEIRTESGVPPSPKEFSCELIDDTEFLLRWRTPEAETINQFELKMTGPLSLFKEFQIKQDESCRLERTCNFTIKNLTGKLRPFSNYSFYLQACNDKHCSKEVQQVYRTKPSNPGIMIPPIVSSINDKLRVHLKPPVEPNGRIDYYHIRIYEQDKLIIDKRFVGNQQYVDVDFDSCKRLKDGDSKEYFLAVKASNLYNNQLFSGNYTDRMQIPLYCSPVYNRILLLIIGFICFIIFLCFVLFCTYRMFKSVKQKNDDFTINIGMEDQSFKDQFQTKFGSNQNYNPNNNDMLPEQSTPQQSQYRETNIDNVSNNNVSESSLMESDLTMANTATNANSSNTINDQAPLSSSGEADPNLLLINHSNNHINDDNHQNNNNNNRNNSTNLAKNSYIKLSTNQFCSSDSGVSDMNHHDNLEYFYNQDDSSLREPFLPNSKKSTQIINNGHRPMNGGGGGGGVTKGIGSFWSKLSSSTAAAAASLATSVSTAATAFYTFGAKLNNYYHHRLPVTTTNINNNNINNSSITKPAYFKPSVPPPTHILSGKLLSAFKRIIFICLNLKLKLFVDTPFLLPFSPMHPSLSSSSLALALIYPFYFLGHLYTVEHKICYNLKNRTKIYMSHLYIYQQKKNSTLPKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7G1</accession>
    <name>A0A922I7G1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FG-nucleoporin nsp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NSP1_2</name>
        <name evidence="10" type="ORF">DERF_006267</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7G1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="9">
        <location>
            <begin position="76"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9522703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="249" mass="27169" checksum="8E228FB2FAE5C38B" modified="2023-02-22" version="1">MAATTTTASISFGLNSSATITTTPASSSSITAKPNTGFVITPLSSSTTTAAGTATATTTITSTPITTATVSSSNASTAVASTPAQLTFGQLEDQINIWMNELTQFEVDFHEQSQTINSWDSLLISNGQKLIEMDKMIEKLNVSLRGLDHQLDFIIAQQKELEQVEDNKLDLGANNVNAEREHTYSLIETVHNDLNAIGADLKDFIKKLNETKSTNHDADDPMIRILKLLNLHMDVLQWMENQIKNIKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7V8</accession>
    <name>A0A922I7V8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sequence-specific mRNA binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SRSF3</name>
        <name evidence="5" type="ORF">DERF_005887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7V8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000078">
        <property type="entry name" value="serine/arginine-rich splicing factor 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9522300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="198" mass="21935" checksum="E36557C769795ACF" modified="2023-02-22" version="1">MMGRRESVPLDCKVYVGELGNSGNRHELEDAFGYYGPLREVWVARNPPGFAFVMFQDARDARDAVRALDGKLICNRRVRVELSTGKSRHEKRGFRMRDGPGGPRGGGYGGPGGPRDGSPRRPRGDPYGRGMPDRGPPPNGPAGGRYDDRYAHRGRGYSRSRSRSPSPIVRGRPRTPPSRSRSRSPIPKSPLSDRYGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I894</accession>
    <name>A0A922I894_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I894"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="540" mass="62294" checksum="EFB9D4E3F6D0D1E6" modified="2023-02-22" version="1">MNTNTNANEIVDSCSNCEDSNKLSDTVSIQSIDSIMISTTTGMANTTSTSTPIRPRPILASAFSFDSGYEISPFSNYSFQFGTESVPNTILTNNNNNSIMATNRLLNPIVQEDYEGIDDELISIDQHFTPIHSPATVENMANGQIDSSSSLMNHFSQRQQAFNLAIQRRENRLIQNEMEINNNDPNYPNAENQYFSFDDFGDDEVFLDNENDDSQPERIMAREWHQPIRPSCSMGIMYDNNEIQDNNNVDDENQVQIDHSYREPNLSTTSSSTSRCSSEPIPIPGARNRYRSSPLLDNNDDLSDFFDGTSASHFMAEQNEQEFSLPDSRRMPYFHRMAPRLLNDNNDYQRHRFGSRFQLSLSMIQDYRDHSECHCSTPSTLRMPSGFSFRFGHQSPNQILYESRRLLTPLPEMDEENDENLIFPMSLDEHHVDDHEEQTFRIMEPIMEQSMNTNEFNEQIIVNDSSSSLNNDDNCPSSMDCLIIMKMVETILLVIIIIIIQMNDEQCPFHYQLIRKQSQKLVENYGKFHMNFICYRFNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8E1</accession>
    <name>A0A922I8E1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8E1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF133">
        <property type="entry name" value="POLY(A) RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="1">
        <location>
            <begin position="160"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="466" mass="53859" checksum="6D2F54E057FAF4D4" modified="2023-02-22" version="1">MHSRQSHIIYRKILHNNNNSTRCSFSSRINFNDLIKTNKNDSKRLILVENLATKNSISMINGPSLSEHLNVKIDQFWSWNYRRRNFVLIRLNKIDDVAKIQSICGYNLHALPIRTRMMETNFSTTGHHSPSKSHYELGTNFKKSLSCSELKDRFPTNEQLIAHLTEMNSLNELDVQLRYFLITQLEDIICHSVFADFNIYPFGSSLAGLGDSTSDLDLAILHAHQWRKNRDINFAMPELKSERDQTQQCLSLIADIVRNFMPNISKVNRILRARVPIVKMSFDLAPIDIDVSIELSPETGHHGLLMADYLHYCVSQHPNIKQFLLFLKYWSKQHGVVKSIPGNWFSNFQILVLAIYFLQNEQILKPINDIDTKTDDGISFNFEKQAMSIQTGKSFAKPDFSPLYIENPMEPTLNICKNVSGVEFKKLLLQAYNSLDAMHCTDFHLANLLDPEYFKTLEKRNNQSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8Z6</accession>
    <name>A0A922I8Z6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8Z6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="80" mass="9575" checksum="E722D9CB8E578B1E" modified="2023-02-22" version="1">MKQGNIIEKVTQHTCMTNVRIWKVVYAKQVNNENGNVQKIMRKRTDGQTFFQRQFLVSLKKYRTKLHYQQIHGHNLSNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I994</accession>
    <name>A0A922I994_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I994"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39299">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39299:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="327" mass="37232" checksum="FC0C437F756BE9E8" modified="2023-02-22" version="1">MIIIVPDSIIINRTGDMMKKIFGYNTWQWLYFLIASAQLITIFVLTLLNLKELIDLKELMSSSFVVNATILIICVISISFLACGIFGFKQNEICLFLLAMSLCCFYIAIEFAFTVQYNSTIKLARLCIALSLTSILLISSKTVAIYSEEYSIIGVSPTLLSMYKLQCFFLVLLKFDFLCAVSFALFNIGVPRDEPSWQFIAMSIFILISIIHWIIGRYAVIKEIQSFLLVFITISTLSLLWIPLQLVTLETCFRFDHCINSILLLSYGSLVSALILIIVRIWMFMQLLKVYKNFGYGLADSAFIGLVSETTRLLMRSSTYRQSIDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9K4</accession>
    <name>A0A922I9K4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">IGHMBP2_1</name>
        <name evidence="16" type="ORF">DERF_001919</name>
        <name evidence="15" type="ORF">HUG17_6887</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9K4"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="206"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="224"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="695"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7636681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9527932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="742" mass="84563" checksum="CB68BAEDD8F2E225" modified="2023-02-22" version="1">MAKSIKSPANLTIESWIQKQLKLIKLDYDEELERNQELRSKHSLKQLEKSGHAVRKLVITNQRTAFAKKVIQFSVRPEKRDLVNLINSGMSHGDIVGVTTQEQTSAHCTGVVLQVKRLTCEIAFNADTTLFDEEKDHLFNLIQLTNDITYRRIKYALENLYERSIRNYLVGLLFGSEPLLDPLTVLPPYTNDLPYPLAGQSNIVWFNSNLNYSQKNAIEFALYQRHLAVIHGPPGTGKTTTLTELILQMITRGLRVLVCAPSNVAVDNIFKQLIHSSQKNICLKYRLKRSFNFVRMGHPARMDSEIQPYSLDSIVMSEGADVLGDLKNEINQIKSETRQNRYTRGQIRERMKEFDQIEEKVSKEKLREAHVIMSTCNGAVMNGQLRYLYDDLNTFSFDVVIIDECAQALEASTWIPLSYAKKCVLGGDHKQLPATICSQEAEKQGLGISLIERVVDQFQNCPDKVVRMLTVQYRMNGLIMNWPSNFFYENRLKADDCVVDRRLKLKNIDELLPVIRLIDTVGCSMYELESDQQSLSKGNIYEVKLVCIVIKDLLDNGLSPADIGVISPYRLQTSLIEAGCRRMYPESVTDQLEINSVDAFQGREKEVIILSLVRSNDEGTIGFLIEERRLNVAITRSRSHLVVVCDSGTVTRNSTALEKFIDYCYEYGKAESASDYEELLDQIVMDQVPQAVSTNSQQAVDVKSNKNNKDLKKNLKANRKQDNNHKNKKKQNINNNNNNFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9U3</accession>
    <name>A0A922I9U3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">T-cell immunomodulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ITFG1_1</name>
        <name evidence="9" type="ORF">DERF_001080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9U3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="8">
        <location>
            <begin position="555"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9527030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="667" mass="76027" checksum="86D320B912DDC40D" modified="2023-02-22" version="1">MPLQNCFHHFHYLITSVFIVFSLITILQSLSQQIVNNNSANRSIIDDDHVDDNYNLINLTDKLSNFNFENFFLPSSSSSSSSSQSQSRLSYGTTKFLAPEAIYSPFNPQSMIENISAIPLAYGDFDSDKFTDIFMLGNNGTSIYLLKGHSCVDGKTVLTFFGSRRCLSIVHDFHCHLSNNVYNLIASDFTGHMHQDLLITVKSTKFKSRYDIILVNGNTTAEEFNCNERKKILINNAKSEPFILDYNGDMISDFIVETDDCSLQLVLGGVTDTTIDTIDLYNNLTIDSKHELKNRYVCLSNLTKIKHLAHPHASGFLNLNSYLIDMTSDLFINGQNEFEYIYNIPQEGFQPNQNGENLYSFPTIASIRGQSSFVDLNYDGKLEHLIPVCLDSDAKSFAQCKQPNLMVFDMDTGDWFSILNTTEPLGTEFNRTLTFIDSRFCDYIEIPVTLHIGDIDYDGYPDFATILFDQQTEQTVAAIFLNKMIDGEKNTWNRIFQLDWIGEYTENVRMVSLFDIFNNGRLNLLITTENAHTNQLTLQSYDYYGEKSLYFSFLPYGGTPPGAMVCFAGPYTDDHCCSVQMSQTAHFALQPPYIIFGLGDVLKLPYEPDQMKNWELRVFINMSIYSLVSLSFLLILGLILTCAISILHFREKVEDRIDNQQYRNAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9U9</accession>
    <name>A0A922I9U9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DHX33</name>
        <name evidence="10" type="ORF">DERF_002054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9U9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17978">
        <property type="entry name" value="DEXHc_DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="112"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="357"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9528082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="790" mass="89367" checksum="F9A09370B9392A70" modified="2023-02-22" version="1">MVPDIALLKNKQQQIQLPNINSATPSPGSIVSTSSPESPSSSSPSCPGRSGSTSSFPSSPENFSSHHSNTHHHNSNDYSFYHHQQRSPRPPTNYHRLSTNKLPVCLVKSQLLDRIQNNETLIIIGETGSGKTTQIPQFLYEHLSSSKYHQPSTLPNGNCTSSSKVTIGITQPRRVAAVSVAQRVSQEIQCRIGDLVGYKIRFDDCTSSNTRIKYMTDGILLREAIHDPLLSNYRVIILDEAHERTVQSDLLFGIVKQAQRLRSGQKRPLDEDSDSSNGGQRHYEPLKIIIMSATMDVDNFSRYFNQAPVIYIEGRVYPIEIFYTESKHTDYATACLSTLFQIHQEEDELTFGDEPTRQNNDFSLIGGDILVFCTGQEEIESMIKIVQSYSAQTNIMKTSKGTVKTLKAYPLYSALPKTKQQRIFDRNLNDCFRRVIFATNIAETSITIPNIRYVIDTGKFKSKIFSPKTGFEIMRVENISKAQACQRSGRAGRLAPGKCYRLYTRPEYRSFSPFPIPEIQKCSIYSVLLQLIALGISNVQAFDFIDSPSIENIQSSLKKLMKMKAIEKENDSDVDYKLTKLGRTMVKFPIDPRYALLLIEAQKFRCTEEIITIISMLSVDNVFDTSMTNEKVIAIHRKFASSEGDLIKLLNVFRRYREAQQKMTWCQENYLRSYQLKQAGDIRQQLVDLCKQASIDLVSTPSTETVRKCLAIASGVGVGLGANIAEFQRDGDFRTITFGQNDRPSMTVFIHPSSCLFSQKPECVLFVELVQTNKSYMRNLCLIDRKWLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAL4</accession>
    <name>A0A922IAL4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001308</name>
        <name evidence="2" type="ORF">HUG17_4512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAL4"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="656" mass="73828" checksum="B2928D8D86EA6FCB" modified="2023-02-22" version="1">MDDHRCLHGRNSTIEFVLLFLIIIIIITTNQIDLAIATNNDQSTTTPTTFINSLIARFQSNGIRGYVLFTENGTSTSISTKIFDNGSNNETYSWKVYNAGYMIDNNDCNVRNNIYLSFDLTLLMGSIEPIRQNIFNVHLNFVTGEHSFLGKTLVLKGNDSGRMSCAIILPFENKSTFIAYFRTNIHGIVYFLQSGNLFSIVSSLHHLSPLIKTSLYDWNIVSMIDNHRSTLKTTMKNDEKNFDSYYKNEIQSCNSSMDNLQPLLQSMETNQISVSSESSTLNSRSYINLLNVPNLTSSSSSSSSTNLYIILRNNNQNIACAPIHQLYPRKTVAKFNEPDYLIGQVMFSQESPIDPTLVDIELKTNKYGYSYGIDELPSISRAAEAHKTCPNINNIIYNPTNISPFSVPIEGLGTSDQYAIGDLSGKYGTLLQKSDEKISTVDFNLPLFGPESVVGRALVFYAPNGTTVACANLELVDVDMTVSFATFDKPIQGQIIFKQPKNRCNEDTSIYFEISRSNDNDTITHNHEWNIHRSPIFTDNSWSTSDCSKTDEIFNPYNKTMDTIYRRDCNGKNLIACIIGDMSKKLSTIEIVPYKINENGDVNLKKYYFIDIHLPLCGPNSIIGKSIQINKNNFDQQSLACTNIVLFESDDDQDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAZ9</accession>
    <name>A0A922IAZ9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAZ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="293" mass="33454" checksum="8902727DC27E1E33" modified="2023-02-22" version="1" fragment="single">LISSVRLLMDNLLRAFILACQDGSIEHLNSIIGKQRPFFPSTKNFGINLRYQRQIKPKLITLVQTNQTIDFNDMCNLLMPSSSSSSSSLSSLKETLYNSNAPSTIIVNGMNELDVGVTEIWFNNIFDQTISTTAMAKQNNDEHEHNSHSSKIMMMNISNQILSISLVPAVSIQVNFEIAPCFEVVFRFYDDDDDNRKHFEKKNCNTNNNKTIIMKANISEDKYKINSSNFDTNTNNDDGCFFNRHQQHHHHHHNHHVYNESIIKTNKSSSSSSSLTTVNTIHCARLMISHRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB31</accession>
    <name>A0A922IB31_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB31"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="95" mass="10643" checksum="1857F143A36CA829" modified="2023-02-22" version="1">MPNSCAKWLNPNFSRKSATIVGDLTNSKQAISCDFSKIFTLPNYWNKVTTAKHLTDTGREKLSGLGDTTNDFRTSTPPSFSNNVQYLVPKWIGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBG9</accession>
    <name>A0A922IBG9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alpha-L-fucoside fucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FUCA1_1</name>
        <name evidence="13" type="ORF">DERF_002877</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBG9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000027">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038205168" description="Putative alpha-L-fucosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="11">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-fucosidase C-terminal" evidence="12">
        <location>
            <begin position="364"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9528967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="454" mass="53295" checksum="036847DC90530B75" modified="2023-02-22" version="1">MFGKISLTILLIYYCLSIVSTNHYKADWTSIDKRPLPEWFDEAKIGIFIHWGVFSVPSFGTEWFWHSWSSHYKSYDEFMKKNYRPDFTYADFAKDFTTELFDPIEWASIFNKSGARYVVLTSKHHEGYTLWPSNYSFNWNAKDVGPNKDLVGELATAIRNVSLRFGLYHSLFEWYNPLYLRDKKNNFRTDDFVKSKIRPEMEELVNAYHPDVLWSDGEWEAPDTYWKSTDFLAWLYNESPVKDRVVVNDRWGKGTLCKHGGYFTCQDRYNPGVLQTRKWENAMTLDKQSWGFRREAILEDYLTIEELIYTLVKTISCGGNILINVGPTKYGKLVPIFEERLEQLGSWLQINGEAIYETKPWHRQNDSIASNVWYTQRGGDTVYAITLGYPKNGTIILGDVHYDQIESIQLLGTDKRVRISPIKATHNETVIEFPDLNPNDKPRYAFTFKIHYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBY7</accession>
    <name>A0A922IBY7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_002626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBY7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9528706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="539" mass="59324" checksum="BC23C01831FC3061" modified="2023-02-22" version="1">MDRHPQFSSNNNNNNSVTLTHSSPPAIHRTFANNDDDSNGGSIENNKKLNHHQQQSYLVMSNAMRSYIESLPEKLTLTKELTEYRFWKSLRTEFIATFLYVIFTCGILAVTTTTTQTTISTTLTNDIQPPQQQQLNSIELLKNSLAIGLTVATLIQCTGHVCGCHLSIAITIGLYVTERVTTLRLISYLFVQFLASLFGIMVVQNLFDTIIPLMPSTPTLSSTKIFGFEFLSTFLIVLTYLANCDPNRLQLTNNSNININNNYNCIIDSSKSLSIGFAYTVGHLFAFVATGASMNPAKALAISILTEHYCLHWIYWISPLLAGLFGGLIYDYIGSIKPISSIATATTLSRPSSSSSSSSSSSIHQIVPSPILSSTSSSSSSCSGTMIDPTTITTAASASIHYNNTANLSMPQQQQPKKTIPSSSTTMMMMMEKPDNSSSSSSTLLPTTTTTTTTMTSPPAASLSTLNPVETTTIRILDTPELPIFSLQKQQRQQQQQQPKFDNDETQFLIVNHKKTSLNNSDDFINETQNKPNLIRTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICL4</accession>
    <name>A0A922ICL4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Duf727 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_002960</name>
        <name evidence="3" type="ORF">HUG17_5004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSKIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICL4"/>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019207">
        <property type="term" value="F:kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060828">
        <property type="term" value="P:regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037395">
        <property type="entry name" value="GSKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007967">
        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490">
        <property type="entry name" value="GSK3B-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12490:SF4">
        <property type="entry name" value="GSK3B-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GSKIP" evidence="2">
        <location>
            <begin position="54"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7641959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9529051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="177" mass="19928" checksum="EC3840B87883A949" modified="2023-02-22" version="1">MSTSADSIIIEQSLHSEDDQETISAEEYMRREKAIKGTDERFLNGDNTDEEGWRSEALAVIDDIHTFVNLMSISSTLPCDNNGIYMNLETKESIRLTIELSSAGFRICGRGFDIIDDSNETDSIEITSPSSSLVDEPVRISLNSYYETPYSLLDTISPSYRNSFSNELAQRLMKLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICW4</accession>
    <name>A0A922ICW4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative exosome complex component RRP41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EXOSC4</name>
        <name evidence="12" type="ORF">DERF_000466</name>
        <name evidence="11" type="ORF">HUG17_8268</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Non-catalytic component of the RNA exosome complex which has 3'-&gt;5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the RNA exosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICW4"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="153"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7640799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9526368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="240" mass="26587" checksum="F7CE987902F754E5" modified="2023-02-22" version="1">MEILSESGIRADGRRSNETRHVNCKLAVFEQADGSAYFEIGNTKVLAAVYGPHELSEQNKNKSIHDRAIINCQYSMATFSTSERKSRPRGDFRSLEINAYLNEIFETVIITELYPHSQIDIYLEVLQSDGSNYSACVNAASLALIHAGIPIKDIICSCSAGYYNNVSLVDLNYLEESIHSIPTICIALLPKSKQTVSIESNGRINVDSLEKLIENVIDGCMQILAAMKTVASDYIKELNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICZ3</accession>
    <name>A0A922ICZ3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase kappa</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DERF_002386</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICZ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000004">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000012">
        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="99"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="516"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="549"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="676"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="699"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9528437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="731" mass="83283" checksum="2F75017073FFDBBF" modified="2023-02-22" version="1">MVDSMSTDSAKPEFINLNVHKAGLDGLDQQRINQIIQEASKGSNFYTFQQRRQKRINEQIEQLKKRANSITDVQRQQAMKKADMIIADLEQRRVLNKIIVHFDMDMFFAAVEIKKDPSLADVPMAVGSLSMISTSNYIARRFGVRSAMAGFIAKKLCPQLKLIKPNFKNYAAESEFVMNIIRQYDPNLRTFSLDEVFIDLTDFVFDGYSKKNNIPLEDLYCMDVLSDDIWQFTNEVVTEIRAKVHEESRLTVSAGIACNTLLAKVCTDINKPNGQFMVKGQREEIMDFVSQIQIRKFTGIGPVRDQILSAFNIVKPTDLFNERVLLSCLFGDIDYYLRVYLGIGSTHLSNNESVQQKSHSRERTVGEMSNFDDICHLLKDISHRLSNDLKNEQQICKTITLKLKKINFEMFIKCKTIDHYTDDEQIVFRVGKELLSQEMQKSPQNKYRLIGLKVSNLCNISNANDKVVLPSDQLTLSKFFQTSTKRKAIESEPDSTHSIDQIDDSSDSNFNENGELECNLCERTFTRITKFRYHRQFCRGNTGDSMYGLSSDSDDDDDCDGDGDGDYSYSNSDNNKDNDDESFVENDDNPYINNGELSSDTIGNKQDGNEAQFLKCPVCQSNTLFNTNEDLNRHIDICLNREVCIELTAIADKQKSDDSSSNMNIDSLVSPMKNIDSSASSHLCKSNKKKSNKKKRRTSTTGTDRTSSSSSSSIIQSANQTKIDHYYEWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ID22</accession>
    <name>A0A922ID22_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003182</name>
        <name evidence="1" type="ORF">HUG17_5187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ID22"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7642142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="283" mass="33216" checksum="2CEFA0FA6960FD3D" modified="2023-02-22" version="1">MATSLFTGCVAKKIFTRAFIAAYKDHGISQKELANWIKLSLYFEDPTRTLKQGMIYYQTIPRYTELFQTGLCIFAFGYYTKQVRALQKYWLHEWIVTAILGRQTIDHYSRSPLIKYHDHSYITDDSIDDSLQKFIGVIEQTGPGYLYEEKQPVDREEVMESDEEESISNGQCRENTPRLKHCYSIEFLDRQDREIKLRITSDGLFNCRSFVRDLGFYLNCPSSIDSAHLEKLGPVKSEQSLQKYQLHYEQMVKLAEEITPACIEYLKQLHRQYPDTKTSSRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDF4</accession>
    <name>A0A922IDF4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_002273</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDF4"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000011">
        <property type="entry name" value="Prolyl alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="13">
        <location>
            <begin position="435"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9528321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="564" mass="65244" checksum="F609CC93DE5106FD" modified="2023-02-22" version="1">MDNDNHSIQLINQRQQQQQLDDCHQNFIRSSPNSNNNNNELLFNKIFAIIILCCCCLLIHQHDGVIPTVQCDIFSSTATIQSLMHLERHLVTSLTLYMENLEERSNQIKMYLSEFAYSAGQKRFAGTYADNLMDNPLQAFQLVKRLTINWNKIVKTVKKDDEWQQVDQLMNSYSMLLPKQEDLNGAALALIRLQDTYNLSLTDMADGYIMGKDSSIRLSARDCLYLGKNAFNNGYYGHSLEWFDEALVRAHQEGNRTASVDEIVPFYQLAIEYIDRLDNELREQNFPRHSDKLRVVEGDNEDYKRYQMLCRGEEFPMDKTELKRRTSDQRCYYSTNNGHPYLILKPLKVEQFNSEPFIAMYYDVISDKEIEIIKELSMPMLTRARVLTDDKDNEISTVRVSQTAWFTEANEPLIGQLNRRIESITGLSVNMNKSDCELVQIANYGIGGHYVPHYDYLIKDKPENQRTNISEKDQYAGDRIATFMFYLSDVEVGGSTVFTRLGIRVNPVKGAAIFWYNLLRNGEGIIDTIHGACPVLIGEKWVANYWIREHGQIFHRPCSLDPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDR1</accession>
    <name>A0A922IDR1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cleavage stimulation factor subunit 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002417</name>
        <name evidence="2" type="ORF">HUG17_10360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDR1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324725" evidence="1">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7636390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="129" mass="14411" checksum="2835C43CD30F87ED" modified="2023-02-22" version="1">MKASLFIGFLLVAIMVITAKAQVVDDDEQFDISRKDGEKFDKKNPKLEGIMFGSIRKTIRILAIGRYGSFDKLKDFLICLNIAILESCSTQIIECLKAKNPKDCMASLVCGKEKVMANCLNHLPDLPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE57</accession>
    <name>A0A922IE57_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE57"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005240">
        <property type="entry name" value="DUF389"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20992:SF9">
        <property type="entry name" value="AT15442P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04087">
        <property type="entry name" value="DUF389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="642" mass="72205" checksum="DB0581B0A49EF5DA" modified="2023-02-22" version="1">MSSVLIIIIIPDQQCEIEVAEKEKLARKYSRKKLKKGLSITIENDEEDENDTNSLENNNFRLSKVGLSYLEIPDATWQKSFNGKYWHISFPVDLEDSDIVIQYFKSRGIGLHLNSSIGIIPFTLFCFNEESAKLEEEPEIELDDKTRELHNFKENKNKFLKSVTARLTVAQIVSSVRDSATLTFDFLCYLIFASWIAAMGLLDNSVVSLVASMLVSPMMGPVMAMTFGTIIKDRSLRNMGIKNIFVCLMGTISFGFLFGMIALNFTQSWTDSLGSNNTYTWPTDMMRERGLVRITWVAISLLSGNDASLVGVAISVSLLPPAVNAGLLWAFSLLKLLYSFGESGKVMTQFQSHFNHSNLIELPQALVPLENYTTVYSDNMALEALYLGMLSLCLSLINIANIIIGALLLLKIKEIVPLSNLSPVSRRFFQEDIKIAREYNQRSETKNLSEDVLREYATIHGYDSEQFMKPEQRAAQLQALNDIAEDVEADQVFQTVTRSVHNTDNNLARRLSQSLFVNQNNGRWGRRQTSAAIFNHQPPTIIVSDALNPRRPSYVHLASHNRLRISTALKNNLNEMNDNLSSTKTCPGYINKAFSFNENDINNYNERKGSDSSVVKLDLETITRFNDKSTPPPSPKMNGTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEP4</accession>
    <name>A0A922IEP4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">AP1G1</name>
        <name evidence="13" type="ORF">DERF_003422</name>
        <name evidence="12" type="ORF">HUG17_5378</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEP4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="767"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7642333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9529543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="887" mass="100538" checksum="F409F6DFE7539760" modified="2023-02-22" version="1">MDNLQSAILSRFTNAMPTPIRLRDLIRQIRAARTAADERAVVQKECAYIRSTFREEDNVWRCRNVAKLLYIHMLGYPAHFGQLECLKLIASNRYTDKRIGYLGAMLLLDERQDVHLLITNSLKNDLNSPQQFIVGLALCCLGAICSAEMSRDLLDEVERLMKSSNSYIKKKAALCAARMVRKIPDLTEMFMNTARNFLSEKNHGCLITGITLITEMSEQNQDALNFFKKTVHSLVRILKNLIMSGYSPEHDVSGISDPFLQIKILRLLRILGHNDEMTSEIMNDILAQVATNTESSKNVGNAILYETVISIMDIKSESGLRVLGINILGRFLLNTDKNIRYVALTTLLKTVQADYNAVQRHRTTIVECLKDPDVSIRKKSMELCFALMNENNIKTMTKELIYFLEKADPEFKSICSSNLCISAERYAPDSRWHIDTVIKILNTAGNYVRDDVVSLLIELISSCDSLHRYSICQLWLQLKEGDLSSKQPLVQVAMWTLGEFADMLLQACGSEELDAIDVDESQTIEKCEEILSMNHVNLVTKEYTISALIKLSVRFPNQTAKVKQIVDFFGCSHSIELQQRSVEFTTLFTRHNKLRPNILERMPQIPKNERKIFTKNEKFDQINKLDSMEQTNELIAATGNSVPPSDSSVLLDLLDISPTSLMNNTTNTLPLAETISTNQTNDVLDLLGSLENSDNDNTTSAISVFNESLVDNFKKNDMNNLDTILQYNNNNVMNGSADGQQNNSIISFNNENNLFDMMLEQEPIVNEKISSITAFEKNGLKIVFHFERNVENPLTISITMIATNTTDQPMNDFLFQAAVPKSFQLQLMPPSGTIIPANNNGSIKQMIRVVNPNKAQLKMRLRLSYKFQDQDTLEQCDVTNFPKKTWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF85</accession>
    <name>A0A922IF85_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF85"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9530180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="80" mass="9058" checksum="5D1108AC75282635" modified="2023-02-22" version="1">MIIGGQIPGRTIEQNLTSEARDGFAMSLEECLSSKTSRAKRVTVLRWSRRLGRQMAKPGPQKYTESNKMISMDQKKNISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFQ2</accession>
    <name>A0A922IFQ2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Intimal thickness related receptor IRP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_003857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFQ2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053880">
        <property type="entry name" value="GPR180-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047831">
        <property type="entry name" value="GPR180/TMEM145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019336">
        <property type="entry name" value="GPR180/TMEM145_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252">
        <property type="entry name" value="INTIMAL THICKNESS RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23252:SF24">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10192">
        <property type="entry name" value="GPR180-TMEM145_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21892">
        <property type="entry name" value="TMEM145_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180-like N-terminal" evidence="9">
        <location>
            <begin position="63"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="GPR180/TMEM145 transmembrane" evidence="8">
        <location>
            <begin position="262"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9530012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="66945" checksum="F48DCA43E6B0C49F" modified="2023-02-22" version="1">MFSIGNVSMQIPLLLNRNVLSFLLSIGLIFHQQQQQRIDARIIEGVIRTNEKVFSNIMSLIQKVYAPQNLLLYFDAKSQWPAVYKQNKTCEQKQAVLIDDFNQVINLTEYRREYKATTASGCRVDRYNNEMNETWYRCVQKRTFQSYRERWWYIALDNCGSRKGLYLKYRITMTNSQSNQWLRHFSADEFYILHTDVIMCTLFYLLLFATCFEAYALYTRHLFHKTYKLYIASLLSGNNNNRMNEKQRIGLIQTFSMYGKKTECLGLLFLCIYYGQFAQQGLASQTLKLIGKAFEAASTLIFLLLLLLISKGYTITRARLKPRTVAKFSMFMVMSSIAYAIIFYHEQYLFDPGEVLYMYESSFGYLLISLRLLAWSWFSYAIVFTLIHYPQKSAFFAKLFLVYSIWFISAPIIILVATFVIPKWMREKIINAVELIIAFKAHLIFFYLTRPSRANKNFPFHVRTTQISIMEKTGNIESGTLEHFNNYKYAPTRSTPIDVFAITSAAFAGLTGAGGGGSGGGVGGGNYTNNNHNIAKGMNSQRMINSAESEITSVASLSNQSGHTSQETFAINGGPDWMPRAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGY2</accession>
    <name>A0A922IGY2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FK506-binding protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FKBP15</name>
        <name evidence="4" type="ORF">DERF_003067</name>
        <name evidence="3" type="ORF">HUG17_5086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGY2"/>
    <dbReference type="OrthoDB" id="5842926at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44927">
        <property type="entry name" value="FK506-BINDING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44927:SF1">
        <property type="entry name" value="FK506-BINDING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="447"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7642041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9529173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="605" mass="70682" checksum="55124E515E37D30F" modified="2023-02-22" version="1">MLKLDSNDDDDEVEIMKSKSKLSNIFDDDGDNNLIEDSKSRLFYKPKQNKKTEEKSSRRSSSASNSSGSKLTVLIAFAVDVYKFENSQYSYVGKFGLALCGNEQESLYRIILYTAKNQPICSATISENFPFLCQQKNYCLIQDDQRQKWSILFSSHSDVCQFCRHLAHCLFSVRFIKHSDNGDISVKQPLGFHEQLNDDWSKKYELMNTLICFRLEITAFEQNYSLHSNLRGSAIWLEESVHRCALKDDNRQLFKWICKNPGDRYYLVIPYSQFDHYRKIIPIEKLDKFVKQKQDKIWKIAIEIEMVGFEAVEPTNLESSHQSSSETLETKDKSIDLATKMSRIGAMPIFPLIQQIQNTADIQRSTTRNEIEEIHNDDQQLRDDNPNRSSVNSLDYFQNFLQTKFDLITKNFEDLKHQIDISKKSNDNNILQHTNLTLDSALLMNSIQKIIDENHKLKSEIEEKKLETTRVQQKLFQMIDRGDTGCLSPPNAELILKLKEEIVDLKDRIQRLKEENYRSMQINYPAPRPRARNQMKQIFHDIRERFNLHPKLESLSEQNRQLVDDVLAEVLTMQIESSDSFTIHNNVSHNNHDDEHEQLKQEPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IH83</accession>
    <name>A0A922IH83_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RCC1 and BTB domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RCBTB1_7</name>
        <name evidence="3" type="ORF">DERF_004165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IH83"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="142"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="331"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9530354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="517" mass="59534" checksum="E55D23F7BE84F779" modified="2023-02-22" version="1">MARLPTENIDIIDLFQDDFKYIDQEYLPSIVSICSLYICDDKKEFILMTIDATWAYGKQICSLLSLEHDMSKPQRISVLNGVKIVQVDYGITFVAILTDQGQVFLASEWKTNKTLQLINTGNDCFKMIACGQFHLLLLRQDGHVFAMGDNSYGQKTGNEKSSLESMIHIDNLENVQLIDLVMEKTETLPCLVPFPNDNSTRIKDIVAGMYHSLFLFENGQLWGCGSSNMVKLVLLTKVPIENVQQIVCSKFHNFSLVYDGSSYYAWGKNGHWSSPKKLDYHPTSFASASTMILSSPITFGLTSTIHVFGSHDPISYQSKSILQLFDNQDNCDVEFIIDKKHIKACKCYLKSVSEYYRLMFSGNWIKKDQVPIQNYSYETYYAYLRMLHTGDLNEQTMTTYLPLITKYEMKELHDKLIHLTIKQMLPKCFRSSIMANSHTDNIDIELFKDDLEYIDQDFLQSIIQIFCFNYEDEKQFLLMTEEATYAYVDSVHEFVAILTEDGQVFLASDVKLRMENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KS19</accession>
    <name>A0A922KS19_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_016035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KS19"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9491306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="225" mass="25181" checksum="D89985F6E3B78702" modified="2023-02-22" version="1">MISTHEVQQQSLNSLILKIKNTTTTTTTIERIFLNDICYRNLKQKQKCISFGLPSDLDPVVFVCHHHKEYPNRPSNHDDDDDDDMDYVVLSSSSSLKIITHITFVIQEFSVEIKTVTIAKFLPICRPFLYIFASISNSISCGPSNDDIMAKRTSLSFVRRISKSLTLAARTPGLGDFTDTKRNLKSTIIGDSTGTTNVKNSCPRPLLLLLPIDGCCFKRCTVTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KTC3</accession>
    <name>A0A922KTC3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EIF4B</name>
        <name evidence="5" type="ORF">DERF_016006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KTC3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="92"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9491274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="771" mass="85418" checksum="0B908F684354B755" modified="2023-02-22" version="1">MSSSQIQNQQANNADTNNSQNVSGKSKGKQKKKGEKLDVDLFFANTTTNWASIMEDDSENDIIPPSQYNLPDAPKALVNEIDPSQLPSVPPFKIHLRNLHYDLEKEDLEGLFKNLTVVDIQMIKDRTIRTAWVEFETKQDLIQALDLNNRAVRGRNISMSLDRGGSDRYGSGDRRGRSGFGGRDNTSSDWRLRDTMPPKQVPKTGGYGGNRGPRRYGDDDGGYAPPPSHRNDYSGGRSGGYDDRGDDRSGYDDRYGRRNDYGHRRGNDSSGGMGGGDGGNWRRNDKPQEEPSNWRREVPSIPHQQQQDHSSYDQPRGGRSLRYDDNNVSSRAMLPPRMASDQQQQSSYRNDDTSGYNDDLYSTPLPTRTSNQSIDHHTDMQQPSSRALRNESSAAYDQRRSINEQYYQSNDQSRSGHRNPPLMDHQPRERLSSTRSNVSNVEPHSTDDYNSSGGGAGGSAPSTAAAPKERRKFVDTSVLDALRKQATETVQPARGSSYSSIFGEAKPVDTTEKELEIEKKLLSSKQAAIAATTAANEESDKSTDQQESTNDVGGDVSAPAATAAISVSSNNTASNDRPNRIDHREYQHRDHRSNDQDSIPPRRRANGGIGSNRMGGVGGGGGMRRDYDDRNNGALGDRRMGGGMRGPRGDHDRDRMGNNAPRMRRDGPRGDSYINNSSGGGGYNDRRRFGDRDRIGGRRGYGDDNVAPRYQDRGPRGGGGGGYDNDRNRYHSSGSDYHEWSNDRDLDSKQISYASTNKFEHLGETDDHGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KTJ7</accession>
    <name>A0A922KTJ7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_014687</name>
        <name evidence="11" type="ORF">HUG17_6530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7644168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KTJ7"/>
    <dbReference type="OrthoDB" id="6495762at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7644168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9493963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="358" mass="41947" checksum="754FA874D7FB8ACF" modified="2023-02-22" version="1">MNDENVADSSAAARIAPTSTIMMNNDEKMAMNMNITNEVYLKFGRPISNEWSEFPGLPFAFEFESNFNRDYHRQWMYDNWYIAIYVSIIYIMVIFTGRWLMTNRQPYSLRTPMALWNLAIALFSLFGTIRCLPEFIHIITQEGIEQSFCSSSYYRDVRITLWYWLFVWSKVIELGDTIFIILRKQNLIFLHWIHHVLTLSYAFFVIGDAPGTARWMVSMNFTIHTSMYTYYTLKAMRFRISRLIAMTITIAQITQMIFGLYINMKAYLIKQSGQSCDTSISASLCGLFIYFLFFLLFIKFFVFSYCSRFPLIGLRKSLRTTTTKTTSNIKNNSIITNNSHSTNISNSNNVRSMKKHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVS5</accession>
    <name>A0A922KVS5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_013052</name>
        <name evidence="3" type="ORF">HUG17_6276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVS5"/>
    <dbReference type="OrthoDB" id="10366635at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324734" evidence="2">
        <location>
            <begin position="25"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7643914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9497039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="334" mass="39475" checksum="EA98FAAA715AAA8C" modified="2023-02-22" version="1">MKTNFCLFLFYGSIIIELIVNVQTKPKTCFELRQEIINHIVAVGPFFHDNYLIFLTNKWIAYNTTINSLIGDIQFDLLTDTEIHDFGPVMNKFISLRHLEKMPISIYLPGHTCDNNNDSELIVTFVSKIDHLYRTYRFDFDMNRLILNVEQSRTNRTYQKIIINDCHNRTILMDNGRLYLLDHNENHNRYNICVQRSNIDRNRMEIGSTINECNDIDQSKLIFSNVRSGFLVSNTGQLYLISKDYLLIFTHNTIIDHDKYFVLTTKSFYEWLDCGDYSYIQQSQQSMNDADRFVSTISGLLFLFFLIYSLFVFYFMFKSNKSSSTYGNKNHNRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KXH2</accession>
    <name>A0A922KXH2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KXH2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="788" mass="94840" checksum="2E43BA4AAB52605E" modified="2023-02-22" version="1">MSLIRWFVSEMIPIKNLDYIQTYLQLQKQIAHNEQHHHILCTNFRDHQKSDASRIISKLIWFQIFQLFRYLLLFFLPLNAEQRILAFDIFYIYGINDVMNLLGVFLTCLGIYLIYKLYLDVPDNVVRLMDMILFKTHGDRYFLHKQHKQQNICHFIRHKMTESIQQNQLFVLALNMFTLYSIYVFINEMTIFFQRITHDEDENILWLTIRYSIMVSYILCSLMNCLFFDLAQFIMAHCYMLIMYVFLFLTWTLFLKLDQINLFLDKKPISGEHHPHYYSRIVNRFLWLYNHTFIQVDRLTRYESDLFSSYLIANFPMNLLVIVTTYLIDNNNQLHAWKFFATAVIGQQLIGFFVIHLICSIYTIKIHKCSHKLIYWSIHFPLRPLSLHVRSSLYIEKIHTSKQYGIVLGGAVVISMIFFLKTVTKIANNDKKVISSTNFGQKSDANRIINHIIWFQTFQLFRYLLLFFLPLNNEHRILVFDIFYIYGLPNAMNLMGVFLTCLGIYLIYKLYLDIPDNVVRLMDMILFKSDGDRYFLHKQHKQQNICHFIRGKMIEFIQQNQTHSDRIIYDDNENILWLTIRYSLIVSRILCSLLNCLLFDGAQFMMAHCYLLFMYQFIVITWTIFLKLDQINSTLDTKRIMNKSHPRYYSRIVNRFLWLHGHNFDQVNRLTCYESDLFSSYLIANFPMNLLLIITTYFFDNNNQFYLWKFLLLLIHKCSHKIIYYSVHFPLRPLSLHIRTSLYIEKIHTLNQYGIIFGRATLISMMSFLKFFFFYLQSLMLMYNLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZ18</accession>
    <name>A0A922KZ18_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="18">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ATP8A1</name>
        <name evidence="22" type="ORF">DERF_013761</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 18">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 18">Membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="18"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZ18"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000021">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="899"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="944"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="980"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1014"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1054"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="53"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="138"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="837"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="15">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="697"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="785"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="791"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="811"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="814"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="815"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="815"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAH9497803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1191" mass="135092" checksum="A41E94289DA267A0" modified="2023-02-22" version="1">MSPTIELRRLSSDQRSLTGRNGGGTGGSIWTRFFRRGSNPLMNYRIVKVTGPNRYDDNSIATAKYNIVTFIPKFLFEQFRKYANIFFLFIALMQQIPNVSPTGRYTTLVPLIFIMVVSALKEMFEDLKRHRADHKVNNSHTEVYEKSSFVQTKWKNLRVGDIVRVRKGQFFPSDLVILTSNEPNGICYVETANLDGETNLKSRSSVAVTDAICTTTDSDGRRKLNIQAFEPNKLLSSIINCDLPNKELYEFIGKIIIDNREYPISPENILLRGAKLRNTEWIIGCVIYTGHETKLMMNSLNKTILKQSYVEIMTNRQILALLGILIVICLISAICSVLWTQHNQSHWYIAELQSQVTANFFLILLTFIILYNNLIPISLQVTLEMVRFIQAHFINNDLEMYDADTDTPAMARTSNLNEELGQVRYILSDKTGTMTRNIMEFKKCSINGIIYDEENFNNLLTIIQQKHDGCEKVREFLTLLAVCHTVIPEPTTQPTENGSKFIYQASSPDEAALVKGAQKIGFEFLQRTPAKVVIDAMGKIEKFEVLNILPFNSDRKRMSTIIRTSEDRIKIYTKGADSIIQRRLCEQSLNDFSQTEINLTIFATDGLRTLCCAYNEIPDDKYDDWEKRYNKAILMPAASLDERTLRDQALNALMSEIEENLTLLGATAIEDKLQEGVPETIETLMRAGINIWMLTGDKLETATNISYSCRLLKNIQALESYHIVKDDTLDSCRESLVNAETKLYEHPEDFTLIIDSKPLGFCLQPQLRPTFMEVALKCRSVICCRVSPAQKAEIVDAVKQSTSSITLAIGDGANDVAMIRAANVGVGISGQEGLQAVHSSDYAIAQFRFLARLLLVHGSGHFPLILYSFYKNIALYVIELWFASVSAWSGQAVFERWSIGLYNVIFTAGPPLAIGLFDRICSDKVMLENPELYRDQSNIFSIKLFWFWIASAIWHSLVLFWLTYATISHDALWVNGRSDGGYLCFGNILYTYVVVTVCLKAALETNCWTLPTHLAIWGSIVSWFFFLIVYSRAWPTFPIGADISNIDRIIFTTTIFWLGLAIIPFVALLVDIIVKLVTRTCFKSLADRIIELELLKEMRARQHVSISERARLLINNFLPASRDTPQQQTSSSHDRVIVSSSIERIESLHPNATDIERDALHGYSFSQEERDPSSAVSHSSVIRLYPNTTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L000</accession>
    <name>A0A922L000_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amidophosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_013016</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:14907"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9496997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L000"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="37"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9496997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="617" mass="68510" checksum="64FBF082CC9ABE19" modified="2023-02-22" version="1" fragment="single">KSKKMCSKKGHVNLLYDIDNNIDDIDNDHLEQLQDKCGVFACIANGDWPTNLDVAHIICLGLVGLQHRGQESAGIITCKWTHEPLAIHRGIGLVSQIFNESAMMSLKGNLGIGHTRYSTMGGADNVQLVQPFMVHTSYGTIAVAHNGELVNSNRLRERILANGVGLSTGSDSELITQALSMEPPEQFKQEYLMLRYKMPNRMSSPQISMTNGHSEHHHNPISVDPNSDTESIDSKSMYPSKFATQFSHDSDKEANFVARILHLMSLTPLSYSLTILFDECIYAIRDPFGNRPLCLGALVPPNTPLGKMENFDNVDGWVVSSESCSFPSVCARIVRDVMPGEIVKLEQHKPPQTLAIVPRPDSMLLILFLDKMHHQHFCIFEYVYFARPDSMMEGQMVYSVRRKCGQQLAIEAPVVRASNDNSDLIVAAVPESSIPAALGYSQEAKLPYIEVFCKNRYVGRSFIQPSMRLRRLAVAKKFGPLSLNFIGKSIILIDDSIVRGTTIGQLIRLLKDAGAKEVHIRIASPALHFPCYMGINIPTKEELIANHFQADQLAQQVGAASLVYLSVDGLRKSVQTGIKEHIIMNNPNKTVSKEELRNQIGHCTACLTGQYPVKLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0Q3</accession>
    <name>A0A922L0Q3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNA topoisomerase 2-beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TOP2B_17</name>
        <name evidence="15" type="ORF">DERF_012864</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06790">
        <property type="entry name" value="PDZ_neurabin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000010">
        <property type="entry name" value="Neurabin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040645">
        <property type="entry name" value="Neurabin-1/2_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043446">
        <property type="entry name" value="Neurabin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16154">
        <property type="entry name" value="NEURABIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16154:SF6">
        <property type="entry name" value="SPINOPHILIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17817">
        <property type="entry name" value="PDZ_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="PDZ" evidence="14">
        <location>
            <begin position="823"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="1494"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="151"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="208"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="476"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="724"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="967"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1147"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1215"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1270"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="486"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1162"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1177"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1223"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1285"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9502066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1584" mass="175331" checksum="D8D628EC9A716F30" modified="2023-02-22" version="1">MANVRAEILAASRSRTTTGYWKDSINRAANNNNNNNNNQQSTINNIGNNNNSQTCAIESVVAMSSSTPSSSSTIGGGKLNSLKLTFESSTKNVIHGDHHHHINGSSSNNNGGKIFNRSHSVPSSSATASSGVGGRKLGTKVSQIANLFQSLSPPTSETNLSSSISTSTSLLNGKHHHHQQQRSSSSLLTQKSNSLISVNSPAAATAAVTTTATSATTTTTTTTTISMKRDSMPNLSNLDHKGNDDQQQQQQSIKTNGQILNNNIKSIKNRMLNDNNNNNNDHHHHNHKTIIDTGKHLTNGSNHSTTTTTTTTTTTVTTQPKKTAIIVNTTNNTNSLDKRKISFDNYCHLKHNGTTATTPVTTTNGFNREHKTKPELLPKTIRQSADMMILKSNVRSPPPPPVSTINGVVKKTLPTLLQRSESRVSRFNNARAVFERLQSSDSIISSQKTTITMNGHNENNGGESKLLTKFNSFDSIRSKSSSPSSLNTTAAAATDETPSTQQQQRTNESNEEVSSPNVKVSHVRNLFQRNDNVSNDDETKVLQSVIVRSNSNASTKENSPVSDSESSSLIIQQQQLLPLNKSTSSSSSMVSCSQDQLLDKIVEQITDPLDKLSNVDLNSCDISGIPDDVNIDECLNNVGVVTDEDAQRLLKEQMLKNDEDDESKNTVFDDSIKLITKNHLATIDSDDKIIDDNCGDEKEEEESELIFIDNIPFHRRKDGEIYMEAPGIPPEEEDDEEENGFLDDPQQQQQSDQYDLETGNIIMPQQHQQRKRNSKVRFSSEPIKVFMTYSAQEYDRRNEEFDPVVASAEYELEKRIEKMDTFAVEIVKGDEGLGFSIIGMGVGADAGIEKLGIFVKTITEGGPVHRDGRIQPNDQIIEVDGKSLVGVTQSYAASVLRSTSGLVRFVIGRERDPANSEIAQLISRSIQSEQQQQQQQQMMLMNQQQQRSIGSDSTMMYQMMENNDEMSTNTEMPQSQPTIPGNKSTSQMNNDQMNVSYIQQQHLQSLRDIDMLKRNIIEWQLKYSSLTDEICKVKQKSDSKIYDLQKQLEDEMVISKEKEAQIITLQKELDQKNTLFNEFKQQYSLLEKKYLKLKKLVKDLQQREQDLLQKDQSFRKMFDDEKQQSTLMIDSLQERITRLEQQIGEKFKSNKQESIDVENDENSSSSSRSSCNSGAITDDHSSKTDRSFKEAISQSENISLLDISYSKQKAELVSRGSLANRQPPSSNIIKKNSSLSRTSSNNDVYSESSSDNNNNNKESSMIAQTEFNQTISSTPKSSIIDEKCSNPSSSSSSPSRSQAKMICQQAVAAIAAKNANLNSSPTMTINVAAASRCGQRNSNISDNQTFQHQQYIESPLLIYEALTPLDASNVRHMMSPQATTTTTTSQSSPIRSMVVDQHLQTSTISSSSGSLISPNSITFDNDDLISMATYSGSGGGGGGNYSFVDDMSHHSSNIYSNESSTANTSATNTLSSCHQQNSLPCMNTFPNSLSVTDWSVLDVVEFLEQIHLGSYGKRFQDENITGARFIQLDSAQLKALGIINSGDRQLLKKKIKEFRQLLDKDKKEQHKVRAGDNHGKIHFRNAFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L177</accession>
    <name>A0A922L177_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L177"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="115" mass="12537" checksum="86D24FC62A4BA3AB" modified="2023-02-22" version="1" fragment="single">TSTHTHKTLCSSTKLTFPGGSRKSLCQLTSGGPGREARPPQQRPLVVTRTNSPRVAPVNSHCCVQLSQSPNSYGQKPVPTRINKKQSPHSIGRISLQTSSTNEAYTTRINNIEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L184</accession>
    <name>A0A922L184_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_014387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L184"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF116">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG5065-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="6">
        <location>
            <begin position="64"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="5">
        <location>
            <begin position="421"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9493647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="558" mass="63833" checksum="338F48EE381732CB" modified="2023-02-22" version="1">MFRYETLIETVDAPLRCSDNQTELNPTYLQELLSSQQQRPNNRQQPTSDYLNVLQFYQDKTILITGATGFIGKVLLEKLLRVGVIRRIYILLRSKHSKTPHERLEELLIKSPCFQFHRQRLDLAKVFAIEGDITRKDLGLSAQDQRRLTQEVDVVFHSAASVQFKGNLRIFIEQNVLGTDYTMNLCTKMIGLKAVVYVSTAYANCNLSTVEEKVYPLNFTIPYAYVNDESIDQFISDILWKYGNTWPKRGHQALWGRPNCYTFSKALAELLLAKKYSNLLPYVICRPSIVTHSAAEPTPGWCDTKNGVSGAMILGGLGIARTMILNGKCNADVIPVDHVVNSLIVVAAHTAIVPVEQRKQVVHLTSGQRNPITWGELLDRSRECVATKPFMKQIRPLAQKPETIDTMYGRLSHQMTKIFSHYGFALLADGLIMLTGNKPFLMNITKRMHLGFDTLEPFTNNEWQFRHENYQDIYYQLSPHEQEIFQSDVGSLDWMKYVDNATLGTRRYLLNDDDSTIDRAMKRQKFINWAHGSAEALAYLGIFGIIWCNIFAQHIHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1K5</accession>
    <name>A0A922L1K5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipid phosphate phosphatase- protein type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PLPPR4</name>
        <name evidence="9" type="ORF">DERF_009513</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1K5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF103">
        <property type="entry name" value="PHOSPHOLIPID PHOSPHATASE HOMOLOG 1.2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="391"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9511027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="669" mass="75515" checksum="5C081C925D3586E1" modified="2023-02-22" version="1">MNRSFPSLSLNSISIIDDDTNDNSNNHHHPVSISTSLRTIPKSINRPSIRSNDDGPITISTQGRCLGLVLQELGVSSIFFPTKIGLKKMGSKNSKCESEENADNKNLMKLDSISTVSMAFTANDGGGTDDGIDGVKPPLCSCQSQRHMQQQQQQQQKQQSFSNQTDVYENKSIVQQQSDRSKSSLPASRNSFVLDMDDDNHIHHVRHQQHHHKSANIDHGDYGFPTLDSIHSTIEKNHGGHSPNSAAAAVNRKSITRKSSSIMLITLFDTLILMMMLALAIILRFTDEIKPIETWFSKRLVCMFPELYSWPFKVVSNTEGVLLFDKLSSTEFLFFLFVFIIPIAAIIFLELNRLLIRQIVHGDHDDHGESIIVPKINLSIPLSVRRTCRILAGFILGLTACSIIADFVKLQTGQYRPFILDICPDFCHGKIVNSNITCWNNNSIADDQRIDVRKSMPSIVATLSSYTAIFLVYYTTAALNYRATKLFRLSLSVAIIVIGVLLSMSRVTTYRNHLWDVWAGWLIGWPLAYYIVWYHLNGFSNRLSISNLFSAKYQCRCNRSNVQDSSMMTSSINWLPFHIPRVQTSAKTANENVARIPSYLKSNSGQVKQSPTTHSNAYINPAFSADDNNPDNHYHYHSSRIILDSNNNQMVKRDGHHQKRRSQMRTFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1M0</accession>
    <name>A0A922L1M0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1M0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="84" mass="10043" checksum="3008ED9A5E494120" modified="2023-02-22" version="1">MQFSHLFKQNIKLFWDFFSLLRFDILTFSNFSLLFAKQLLISYSSVLHCVLFIVQKCLPFELLLQPIIFIHMIENIPIVQHSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1Q1</accession>
    <name>A0A922L1Q1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1Q1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037295715" evidence="2">
        <location>
            <begin position="28"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9494187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="251" mass="29316" checksum="C712B50FB02026C2" modified="2023-02-22" version="1">MSKLASFWFWEIRFLLLLLLYVPIAKLQHDTSLSFNNVCITNSDCQSLSNHSNETELNVNNVVVVDDDDDDDLLLSLPLFCLDKSQCLCNRLQTSSNKPFYTIDGQCIDCNFEIIKLNGHFIDPCVEQDPYSQCNETNGQCECLTEDQINQSLFDYQDDGHSDQNHRKQSVCFHHLIERKFETFINSTHQTMMNWTQVGSDQTKSFDWILATIFAYILPFISITVFLYFIYRSLYRPDEDRDSEMILYQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1X7</accession>
    <name>A0A922L1X7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DSCR3_2</name>
        <name evidence="14" type="ORF">DERF_013028</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1X7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="RIO kinase" evidence="13">
        <location>
            <begin position="640"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9497010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="948" mass="111216" checksum="E4E2B2E91B8799DB" modified="2023-02-22" version="1">MLIIKKNIYPMRPYRKRDIASIFLQNFENLKFFNSRLEFSLSDYEQRQISIRSLQTIQNSIWITTMEILTIITFIICIIWPNNDYTISLRLLERIIKMERIDLIMINLVFAFGLVHCFWLYSFKQATTYQCSLIDCCLANSSCTVNDRFCPEFRSYLINFYAITNMVAIIIIRTIIFAHLILLIINIYAYIHFYQLNILSLIQLIISLPLYSITVIYIAYIMSEICMNTNFLIFTMVFIELRLKQLFEMTKTMLEDDHRNMNPFKIRNILYWKKFQMQYVQLYAETARLNQNNNQQTLMNSENTFVTIVSISIFCFINGLYSRASRLPSYNQRCVRSIFVWIARSQFNKSIPNYYLKRIILRHLIKLNLFITTMTNNRFGFTCVLKRNCYKEMSNKTWSELVSQSSIGQEHQQQSLTSIETLSPPPQQQQSISLNDIMSEQLALDLSVNQCSSRDYKQISNQSENQITPDYENPLNNMTEELECSNDEMLAKLLQHELDLEHDRMLKLEEKQYNANSKVQLSFEKLRRIRDEDLGDSDLDDEIHHEYGEESKHWDFFEQKEKQAPKIGKQGYVVAKNGEVTTKHDIELNKCRNACKVMEFESDIRTGDGGGFPMKLSNNVYNALKVHSISEGKRMARLHEKKEKSSAEKAVDAKSRILLFKLINGGTLETMNGIIATGKESVVIHAIGQNIEKGIPLGEVAVKVFKTTITEFRERIQYIVGDPILEQTGKLSKQNPKLTIPLWAEKEMHNLNRLRKFGIACPEVVLLKKHILIMTFIGREGRPAPTIKNLKFPEELFNRIWTETEKLMIRLYKECDMIHADLSEYNLLWYENKLWCIDVSQSVRTTHPMAFRFLWRDCVNICKFFSKKLCDFKSPCKLFETITGKNMSELEHDAVVIELFDKMENYEKSRKNVDICSFETKQQCEPDMFDELFEKALQQNRAEGFVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3M2</accession>
    <name>A0A922L3M2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3M2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
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            <begin position="208"/>
            <end position="261"/>
        </location>
    </feature>
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            <end position="307"/>
        </location>
    </feature>
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            <end position="453"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="221"/>
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            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
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            <begin position="339"/>
            <end position="349"/>
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            <begin position="703"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9512121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="744" mass="76299" checksum="FCDAD60CECBC42E5" modified="2023-02-22" version="1">MIFAKQQASAASAAAAAAAAAAATAAVATSIPLSINGNNMMMNSMINNLQHNNDNNNNDNELDKNNDIIVKESLPSATTLTETLINGNKSTNSISALSSPSSSSPHSIVSIISNVSNHHHHSHNNKNCEKSTLTLKQNCKSFINKKKLSRSSLSPTPSPLSSSSSSSSISSNIDSEESIILTPPINDTSIKQLLPITTSPSLFHQSQTSAFYLPPPPPPLSSSSSSSSGTLISTTTDSIMTTSGRNNNNSPNSQSTGSSSSAATAAATAAAAAAAAAALMINMNHHPSHLHHHHHHPQQSLPPSSHAIHSHHTVASLAAHHHHHQQQQLTNGLNVAGVLPPPPPPPPLPNNHHHHHHNLPLHIPHPNHHHHHHPHLNLHSPLPAHSSSTAAAATTSFEQVLRSAAAASIVTGNATISPTSSPINHNNSGINSGHGNKRSRSPSMHGGDHHSSMVESSVAGFQKFFKLSSTQQQSTLNDNSDDDDALSVSSIGSSTRIHGGGSGGGGHPINLIGSAASSGGGGGGRSITPSSSSSTTISHHGAIGVETSSPFASAFSSAVASSNFLLRNSTSPTIISSPSSSSSSIKHPAFTSLAQDPNTLAVINAAAFAGNFTGTGNNGNNGNGDNTTQNIGGNNGSSGVNSSGSTTPTSPIGDRSSSSITTTTTTRRSHSTSAAAAAAAAAAAIDASSCASGSSTSNDSSRHPKCSKCRNHGSRVPVKKKQKKSNKFGFKCCQNKTKRKNKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3T9</accession>
    <name>A0A922L3T9_DERFA</name>
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        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
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    </protein>
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        <name evidence="12" type="primary">PPM1G</name>
        <name evidence="12" type="ORF">DERF_007624</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3T9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="23"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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        </location>
    </feature>
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        <location>
            <begin position="456"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="173"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="206"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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        </location>
    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9516911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="516" mass="57885" checksum="BD991C34198BB33D" modified="2023-02-22" version="1">MGSYLSKPLTKIDSSICENDHFIYCTAEMQGWRKTQEDAHVAILNYDDKDSVFFAVFDGHGGDEVSKYCALKLPNFVKNSSLYKEDKIVEALEDSFLKFDNTLKESAVVSELKKLANIDEANEIDENETSDLRKEASIPIEEIINKNFKCYENDKDNENVQNGNSDNSDEQESSSTSSSSDISLKKKSLLLRSETLKAFLEDYLNEEEDDEEDDESDEENGEFSDSSSNDDEENDEENDEEDDDNDEDLDDDDKNDDGEDVATGLKNFFNLDYEPGKGSGCTAIVAVIRDNMLHVANVGDSRCVLSREGKALDMSEDHKPEDDKEKERIINAGGEITHDGRVNGGLNLSRAIGDHMYKNNTKLSDREQMITALPDIRTCSIDVEKDDFLFLACDGIWNSMNSQEVVDFIKERLNNNVDLKVICEELFKACLAPSTDGDGSGCDNMTCILVRFKKPSENSTNNGNSSKRSLEDDSTNHSSTSTLNDEHSESNNKRIRNNDDDETINDDLYKPGSSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4F2</accession>
    <name>A0A922L4F2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">UBE2K</name>
        <name evidence="6" type="ORF">DERF_008549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4F2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9517933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="204" mass="23662" checksum="CF7EC7BC65DB2FA8" modified="2023-02-22" version="1">MANIAAKRIKREFMELPQTENEPNKLFHIEPVDNNLLNLTGYVIGPSESLFEGGRFKVEIKIPETYPFNPPKVRFTTKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSIQALLTSPEPDDPQDAVVARQFKDHPDFYRQTAKFWTYYFATDRSAEKRKQFESYEGTKIKRLRELSHIDEERAICALSQFNWNIEQALQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4N3</accession>
    <name>A0A922L4N3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_010077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4N3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09093">
        <property type="entry name" value="INPP5c_INPP5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000004">
        <property type="entry name" value="Type II inositol 1,4,5-trisphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037793">
        <property type="entry name" value="OCRL1/INPP5B_INPP5c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="838"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1033"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9511630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1096" mass="126890" checksum="70C5DD9CAC58741F" modified="2023-02-22" version="1">MNSRFFLQTIKDDDDDDDNNKKKTLNNGETTKTNHQTDNKMATTLKSNHKCLAKLNVTIILGDDDDDDNNKIQSSRLIGLIQADYGSYGLFIWNNNNNNQNDQNENIPIETIIPIDQRFHYQLENGTDLALFITYDECSPLTTTTTTTTKTINKSMTLNLETENDKTISVKDSILLEYDPLMIVDDKIESNNDDDDDDEKIINKQSSSSSSSYRFILSYNEMTEKFISQLQHIVSVSSNGGNNDNLRSISNPSPSSSSSENKLKNSNSSNKLINLFDDMNQQQQQYENHQMKSIINNNNYIEPESPEHFGDYDTDNFLNSDFNRELQIQTATEERRNEYVRYVNYTLFIGTWNVNGQIMLNTDVMRTHFLSIDANAPDFYAIGFQELDLSKEAFLFNDNKKEDYWLQICEQSLHPERQYFLLKKIRLIGMMLIIFAAREFRQFIKNVAAETVGTGILGKMGNKGGVAIRFELHDTSICFVNCHLAAHVEQFERRNQDFREINSRLQFMNLKTPKRIYDHDQIYWFGDLNYRIMTSDTDYVKKLLNLQEFDKLLAIDQLRNQMLEKNCFQGFNESIIRHMPSYKYNTGTNEWDSSEKRRPPAWCDRILWRGENIHQTVYRSHPELKDSDHKPVSALFESQVLLIDHQLKRKVYEDVMKKLDKVENELLPQVSIDTTEINFGTVSFKDNSCRMLTLTNTGQSRIRYRFINKPNDKNFCKQWLRVTPATGMIKVKEEIIIVFELNFDDISMAYRFNYGLETLADTLVLSLIGGKDIFITISGDYRLSCFGCSLQTLVQLEQPIATMTLKEFQQKFGDHHVSKLPNYKERLIDIITESMSTMNVNDNNNDDGLPLPKELFILIDHLYRNGYVNVNIFQSSGMENEFFIIRDSLDSSDPNRIANVSEHSLAEALLLFLETLPESIIPFIFYDRVQRANKNHSECKQIYNELSEIHRSAFHYLMMFLQEMCNNSGIDKPLNKLYISKLFGPILIRRPPESFYTFNNNNSDNNQLLIDIHQSGHQQQQQLLQQPYGTIKSSSSSSSSSSSLSSTTIATAHQQMSCFSGQPMNSGSIGNNEKYKIDTLTPEQFFINYFLNLNTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4Q2</accession>
    <name>A0A922L4Q2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_010129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4Q2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="560" mass="65478" checksum="4331FF0645435CB7" modified="2023-02-22" version="1">MDKILIIVIAIFIAIIIVNGDNRLLSSASQPSTTTMFSIINITTIDDHNNNDNRTINDDDHHHHENYSSLVSHHLDHHHHHHHDNHHHYSYFLTSIPLNYSKNSYKHHSIISNNNDNNVKHSKKLPTKMFKKDAQPKLTSMKMIMMAKELHEKRTNIHGSNYIDNNNNNNNDKLCSQYHNSCHECLRQNHHHHYGSIEFKNQESNINIDDDGIDNKNHQNNNDNDDDNNDQYGDEDQYCIYLICERRNFCINIKNPLLNYFNMDNRIMDSHCRLLNECPISSSNDNVGDKTKEKEQNNDNKKIEQHHHNQYYYNTNNEKVPKFSNYKQDNNEDVFNQRKKHFHHHHHHHHHHHHHQNHRSHHNHHHHHQQQQQQQTASVSLPLSSSSSSSSNNYRNFFTTGTLFQTPIIMMNNAQKRQQQQREQLNNDDDDDMTMKLQQTLKLNDKKNRLYGSSLFTSEIGSKKSTAIHSSSRSDSTTIDMNRINSSNNNNHYHALVYHISLGTIMALMLCSTLVLAAVITVAYKKIHRIYLNRNNTYDTLNNETSLSPSSSSITIASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5A3</accession>
    <name>A0A922L5A3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Williams-Beuren syndrome chromosome region 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">WBSCR16</name>
        <name evidence="4" type="ORF">DERF_004541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5A3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053035">
        <property type="entry name" value="Mitochondrial_GEF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46337:SF1">
        <property type="entry name" value="RCC1-LIKE G EXCHANGING FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="51"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="125"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="190"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="247"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="300"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="357"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="415"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9520856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="466" mass="51604" checksum="D0D57BCE9702495B" modified="2023-02-22" version="1">MTMMMTTKHRPYTMTSINQSRQTRMRPQDPEEVANMDEYQFADEKHSTKRSKSIFCWGFSSTGALGRQSHLGRYEKATGQIEIPKRTVIRSPQRLRFVNPRCHVYDVAAGSGFTVIAATYDGSTHVLFGCGLNTDSQIGFQSNQSNEPLICVAEPVPIDLPLNNSNKKNMEKVVKVACGRAHTVCLTNHNNVFTLGNNSFGQCGRPIVEDEKYFASKRVHQIDYDQNDPIVDICCGLDHTLALTRSGIVYSFGWGDDGQLGHGVCRSSWKLSKVIGDIQGEKIIKISSAGDCVLAINEKGQMFGWGNNEYGQLAMANNVNQTQIHTSRHLKVDNNSIGKISDVAAAGSMCALINDSGSIFVWGYGILGLGPNIREKLWPTELHANLFGRNVLNMDTKITKIIAGLHHFGAINNRGELFMWGKNNRANLGIGTKHDMMFPFRISIPTHVIKLSLGIDHSIAVGYRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6X5</accession>
    <name>A0A922L6X5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6X5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8364" checksum="7F377F8FD06DDDC0" modified="2023-02-22" version="1">MTIINVNDMYINEQTFLCMYFISVRARSIENFNFFFFSFLAQYIHQLSTAAAAAEEEEEEAAAAVIISFRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L825</accession>
    <name>A0A922L825_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF87">
        <property type="entry name" value="CRESCERIN-LIKE PROTEIN CHE-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="1942"/>
            <end position="2177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1613"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1753"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1327"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1383"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1407"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1625"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1647"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1686"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1707"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1757"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1789"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1810"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1823"/>
            <end position="1834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1856"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1884"/>
            <end position="1899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2207" mass="247904" checksum="8C21D9E28BC7978C" modified="2023-02-22" version="1">MDWFELNSHLRLLRQSKTQNTSFLKQPLGTSTKSIQASNVSNAQFVISGQRLETLKSLRKLLRKFPSRLNHSTISSIFDVLKSIIAELTLIYFNLDGNLTNNQNGSNNHHPHQMVRWNSMAQIPTNSKTQPPLLRKTLSTDNVFIAAVRRNEILECIQIIIDLISMKSLAANQDQQSQSANSNNQQLLTSASTNAEYDAQDLGCQEDYFGRTFLPEIITLLGHESSDVQRNSIRFLQLYISRTHNLQRTMTTFIEHGVESSITGTQFGALNALPHLFVREELRAENLGPLVSSLGQMLVRTQTDKPHIFYPTYVALERINSLIGSKRFYQYLFQCGLQSDQDGGDISKKAVTIYETVQKRAPSPQVYIANMGLHTFIDSSSTATTTNNQQQRRGSKGSRRYSNASTINSSKPNNSKTVDDKQQQNANNKMKPGQGPVGQIISTVDNRRFTTNLPIMEEEYDLEPEQEMMMMMLNGASSHPSIRHWANEQMFTENDDYDNYNDDDDDENQAIVNDHTNHDVRDDLISPSHENDNNDDGQQQSHDDRTEIHRDYPVATANGEERSLENEELRTKKWVEKEAADTFSNREQEQVLLLANLDHPHYNYRSNQRQEQDKKDYYDDDRHGECQNLDSLNNNRIMDVLPNINYQKDMIRRQSITAAATINGDPYVASTTLDTAMMDHEGPAVRTTQQCKLVTNNENDNKLSKPGKPLSNYDQQQQLEQRLITTKEKEEQNQVQEANPLLIHNNNNDDDGTGVSQEDESSLYSNDITDDQRCGHGQEPDFKTNHNSNDNDDDAENMVKSSGGQGRRLSIVADGTTVNRNNNTKLQQHSNRSSKQTSSSLNPTRQVTFANGYRKGSISTVIGPKIAKKPTTLSVLKTTQDSPGSSHTSRTLSSDEDDIVAHQNRSIANTRNNQLADDTTDTKMAAAAASTTNFIPQGSLASLTQLDADTLANIEYIPTMKHYLLPYYHHSYYHDLLYHPTTLAAATTSPILYPPTAASLVANPHLLRFGIFPRVLIYQALSSIAEEQFAAVQAIVRIVRDAPNDHLLLLLPHMDEFLSVFVSQLLLDSSSNFKIILWTLDIIELLTERFKLRIHPHLSQLILLLSQRLGDNRIVIRDSVIKVFHQMMTRYCPQEMLDLLFKHVSSSAQHQQPLAFTSASKLREEMANRVNASIATFPRSRLNLPKLCFDIAPLLIDRRSLVRLASLECVATLAQALGPHKLGSLMTAVHSLETTLTAIDFDRLIASIQARLARRSLARVGPDGNVHYVLRVPTSSESWYYRRIYDADLEWIALGPTTPPINVPPLNTPTVVVAPKFPSKNCEDLSSESSEPPRTNDSSPATLKPESCQERMTIQQQRLLNSPDSEDIPPPVKSKVTVGGVQSHHHHHHRLRHNRSSTSPEPDAHKSVKIRSRSRSKTQTQQHSSSRKTIDPDGMAQDPPSPLRNFSDRQQQQEIEQRFHSLEAPQLHRSKTSQEFRPYGKHKARRDQFIERLVRGESVDDSDLADAQWFRRSSTESLEAWRQYFGRFKKQMADISLLSGAGRPYGSRPGSSIYYGLSPLPPFTLPAATFAPPGFLSPSYYYHYYIANGLSNSYHDLSQLQQKNMMSIMKRSGFISGSDQDPDPDIDRDRDHESKRHKPERIVDSKPSANDSGQHSKQILQGGQVNGTLKNIKRSSNNRDENENNLPKQESSNQLDSEPLPLERSFSMPSIRTDSSTENDQHLHAHQNAQDNPQVISDEVIQELGMWEQVIQEEKNQQSLDNNAIEQSTENVNDANQIEAKPQAKIPTVSIQPSTPSVQSTSLKQSYEVSSSLPPLPSSSSSSPPPPPPPPSPPSQSSHTDNDDEQQEQPTSNAESKPEESIKNVDDSGRPTESSPKGNVDSKLAQTTTAKSKPPTVTKTGPAAPPVSRRMSKPVQQLYIKTTPAIPMNANIQHILGNVARTEGPFDNPYDAVKAAVIALRDHAWTTKVEGMLAVVRLATFHPHHLIRDQHQISLALAGETRNLRSTVARSAIFTIGELFSKLRSQIEPELDILTQALLHKVIENSVFIREDIDRALQLMIESMPQTRAALALITFGSSHRNTHVRRSSAQFLSALVEKMGPMKCLLGPRDIGENLLPAAARFIQDHSSHTRYFGRRIFAALMQHPLFDKFLRRHVSPGTYRNICGMLETIKRRGVGDAPSDLYSPTVQPKESDPRRLVVVEATTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9D1</accession>
    <name>A0A922L9D1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CARM1</name>
        <name evidence="18" type="ORF">DERF_001412</name>
        <name evidence="17" type="ORF">HUG17_4592</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9D1"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070611">
        <property type="term" value="F:histone H3R2 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000002">
        <property type="entry name" value="Probable histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000031">
        <property type="entry name" value="Putative Histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF10">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6 14 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="16">
        <location>
            <begin position="297"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="607"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="616"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7641547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9527394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="693" mass="78474" checksum="DF76B102975B22B0" modified="2023-02-22" version="1">MSSIFEEVYLYDYDEEKLTFYKRYQKPFNIEVIDESDKLLIRSRTKNNNDNYNNNTSLNNNINNNNNNNSTTSIQFQAEIYKDTPCSEFSKNGFVITDENGKSVHLLFGKKYIYDNEKANYKETDFCRFTKLVNDFKLGRKESVFTLRTDEASATQYFQFYGYLSQQQNMMQDYIRTSTYQRAILSNLEDFQNKIILDVGAGSGILSFFAVQAGARKVYAVEASSMAKHAEQLVASNKLADRIIVIPGKIEEISLPEQVDVIISEPMGYMLFNERMLETYLHAKKWLKPGGNMFPTRGDLHVAPFSDAQLYTEQLTKANFWFQQNFHGVDLTALRNAALKEYFYQPVVDTFDIRICVAKSNKYSVDFLKAHEKDLHVIDIPLKFHINQTDEIHGLAFWFDVAFFGSQQAVWLSTAPTQPLTHWYQVRCLIDKPLFVQRGYTVSGRVLLVSNRRQSYNVQIELQVDEIPGSHSSNSLDLKNPYFRYTGQPVQQPPGCNQTSPSEDYWQQIDAAQQQHMNGGNLINGVCSQPTNQMNTNGGLAHSLQPQHQQQQTGMGHPVLIQQQTSPLADQIQNQFVSNQTNHHNNSSRMFGGSSGIAMTHSNAAFSYGLPSHPNSMPTNQSAQQQQQQQQPQQQTPSMMTSMFNSSGGGSINANSGQVAGINNMNFPVNQSLMIGDYAAAVSGQTIPPYKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9E4</accession>
    <name>A0A922L9E4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_002196</name>
        <name evidence="10" type="ORF">HUG17_10163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9E4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF73">
        <property type="entry name" value="SODIUM_CALCIUM EXCHANGER MEMBRANE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="102"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="354"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7636193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9528236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="522" mass="59585" checksum="884E39A82E50EDEE" modified="2023-02-22" version="1">MVVLTNCSKNNNTTTTTTTTSTKIIATTAKTTTTIISVDELVDQIIKNQSNITVLPNRIGENYTIEDDRDINPDLINVLSFLPPDFMNAQLRRNGGYIVHILIFCYLCFVLTLVIDSYFVPSLQMFSHVYGLSPNIVGSTLMVLGTSSPELFTSIISVFIGGKSIVTGAIVVSSLFNLLAIPGICGLMVLTPRTFTFIRINAWPVRREIVFYSITIVVFILSIKDDSIDCIESLIFIFIYTVYMLCLYLWSNFEIIQQQQNRRKFFHAQDRPWLKYTHYLQQSKINMKPAMKKLTIANPQQPSTSGSQENNNNGGGSTLYRGTFPQDKYLKSILIPFQWIFSITIPRVNRRSFIATYILSNIWIVAITYFLMWMISIISKAIHFTHSSSVLTMLALGNITKMISSIIVIKRLHLVDMVICHAIGSNIFNILICLGLPWFLKIFILTVKEGTTLEKLQAYTIDIDYRLFEYVAISLTLLLLIFIFIFYLSNWKLSIKSSYSFTILYIFFLVCLLIFDHYISIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAX1</accession>
    <name>A0A922LAX1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAX1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7645" checksum="E1E2934F0999CF97" modified="2023-02-22" version="1">MINKTPVLETVTIEINEHKPFNIGKQTDKKIRTFDTTSFGVDVFSHFWRNLILDNEKKDYSSNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCH6</accession>
    <name>A0A922LCH6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCH6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="125" mass="13873" checksum="35802C4EABAA6004" modified="2023-02-22" version="1">MECTVNKPKENLLSRLAFSLKTESISIKSSNVRFPVPSCENTLQILSLNGFSFNSAILIIFSIGIDMNSDTTPIMLSLHLPPVNSLCLKDCSSSSSFIDKLPILIDWYIIFYHESCIGHSTLTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCR9</accession>
    <name>A0A922LCR9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/arginine-rich splicing factor 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SRSF12</name>
        <name evidence="4" type="ORF">DERF_001000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCR9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9526945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="200" mass="23870" checksum="C6ABEEAECD94BC70" modified="2023-02-22" version="1">MSHHHHHHRYDYSSAPKPNRSLFIKRVPFQTRSHDLREIFEKYGPVKDVYIPKDFYTGKIRGFAYVEFERLKDAEYAIRKLKYDRLWGNELCAEFAQGDRKTPTQMRKRNNYSTTSYGQRSPISNEYYSQIIIEGIVHDHHHQAIILIVIIIKNDNHLAVQDLVHHIIIKNIDQQVQSQAMIQDFFLTRKKTKHSKQKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCX1</accession>
    <name>A0A922LCX1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCX1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9530352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="106" mass="12152" checksum="B8FD3138FEBF7300" modified="2023-02-22" version="1" fragment="single">MRRIGMAKTSVKKRGHVSQTYFWARKKLWTCPPRTVVNMSSERSLEHMVYVTSGVVKPIGSGKNHIKVHQSSSHHLGSFLLTGRFNLPPSSLHFYFSNTCIFILQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LD77</accession>
    <name>A0A922LD77_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LD77"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7276" checksum="51F31EF7F2AACC2F" modified="2023-02-22" version="1">MHYYIAATILLCHEAKKKCTRLSIDPGDLLLGFSTTHIIYNKKRDSPEFEMENRCDNCNERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HFJ7</accession>
    <name>A0A922HFJ7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_015894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HFJ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9491162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="69" mass="7993" checksum="3381BD32A938209A" modified="2023-02-22" version="1">MNDTSTTILYDEINAEKKLLKQRKLSLFSDKKKYPDQAINLSTTVGNKNIYFFHIAVYVNQQVTFVTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HHT6</accession>
    <name>A0A922HHT6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DFP2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HHT6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18169" checksum="4683B7E96C08D521" modified="2023-02-22" version="1">MLLLFMPLAMAQPPPPVLQRDPHSITLHELLVSHGIQNGQMALVMVAPLNAEQALQASAGTLQNQLVNRPLLVQSPAQEVNVHYRSQSAPLNVQHTHIPAPKPELQLSRSEEEPHKLVHEIVRPVIQEVREIIQPYRRIIQEIRPVQEELVQKIAKNSNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKF4</accession>
    <name>A0A922HKF4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKF4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="303" mass="34916" checksum="A8563224018C0226" modified="2023-02-22" version="1">MEKSNSKKLDEQKLMEKSKSFNEIQKKSNSNKKNNSITLSKQNVSVMMKKSLAKTGSKKNMSSKKSKSLTKSKKPKSLVKSKSLQKSFSKTKKSSGKKSSKEKIIMKSKSGSKKHDLSLTTKTSSYRKIKSTSKKPIHESKSFTKSKLDSSLIGVKKQENVEPLSKSFVQTEMSKKSSMEKSGLPIPSNPLIESKIQPSSKVNISESNVNENEKRIESRLIQVNVPEKVQKQLDEIIKNLQKNDQDDEWEYFYDRIEWPEFDNDDCEYEWIDEKDIHKYQPEQIIRVDYDPDSKCSIDFKSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKT2</accession>
    <name>A0A922HKT2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">GID complex subunit 4, VID24</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Vacuolar import and degradation protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GID4_1</name>
        <name evidence="4" type="ORF">DERF_013022</name>
        <name evidence="2" type="ORF">HUG17_6307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKT2"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7643945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9497004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="269" mass="31422" checksum="6494D30726B82CEE" modified="2023-02-22" version="1">MPVRYSSNITGFSQQMLHNIDDNCDCICEDDCCHEKANFPNKNADVNNYNSMMKSSTTATSTVNKPKIKPTLFCPSPLIHSSQLGITHSLLFSGSKFGGYQKSKGNSYEVEVIFQNVDESNSYLCGYLMIKGLTEEYPTLTTFFDGEIISEKYPFLTRKWEADEDIDRKHWNRFDSFAQYSKTFNCDNFDYKQLENNDHIFMRWKEHFLVPDHTVKDINGASFAGFYYICFTKSKATIEGYYYHRQSEWFQSLNLKHIPENSIQVYEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HL48</accession>
    <name>A0A922HL48_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG1</name>
        <name evidence="11" type="ORF">DERF_016058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HL48"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9491330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="447" mass="52154" checksum="1097AA38D8416106" modified="2023-02-22" version="1">MTNPHQTRSVCICVSGDIGHSPRMQYHSLSLAEVGYHVDIVADQESRPHEKLLSNPRIRIHPLSSYQSIRCSNRFSHIPPGFPRIINYFFKILFNTIFLLWNLMLIPRPDYILVQNPPSVPTLAIVWFVCRIRSCKFIIDWHNYGHTIMALSLGAKHPLVRLYSRIEFNFGKRSDYSFCVTRAMKDDLRERTGKKAIVLYDRPYSFFQPITSIEEKHLFLVKLKSEYSQLEYHGQNETLFTRYSFKNDEYQMKSNRPIILISSTSWTKDEDFQILLDALYEFDQNYANKVIGTDNDLKIVCFITGKGPMKSYYIRMVEKSYSFRHTRFVFPWLSAEDYPKLLACADLGICLHKSSSGLDLPMKVLDMFGARLPVCAYHYKSISELVIEDQYGLLFNDSASLVQCLMRLLQDFPTCLQLKRMQTNIDSSFDGNDWHSNWKLNALPVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HM31</accession>
    <name>A0A922HM31_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DERF_013371</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000010">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000007">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.750:FF:000001">
        <property type="entry name" value="Putative phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="46"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="194"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="465"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="679"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="853"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAH9497376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1332" mass="148341" checksum="5612363DFC67B050" modified="2023-02-22" version="1">MAFMTNIIRFYQNPALSNDQEKNLLNKVRQQFKNGGDEIIKSVQTEFCFNIEQQAQLSSDELSKIEWILTPDFNVKLDRESSRLRSLNSSSSKNTVLIEIGPRLNFSTALSTNAVSICKNIGLDKKISRIEKSTIYLFEIERSMTKEQENQLVESLHDRMTEQRYHKPIESFKLPTNDDKWFEIDVIGRGEQALREVSEQLGLAFDDWDISYYCSLFKDKLKRNPTSVECFDLAQSNSEHSRHWFFKGRIFIDDKEVPQSLFGMVTSTQDNTNDNNVIKFSDNSSAIRGFSDLNILIPKDSTQASSMELKKDQTRHIIFTAETHNFPTGVAPFPGATTGTGGRIRDVQAAGRGAHVIAATAGYSFGNLHIPDYHLDWEDDNEIYPHNFASPLHICIEASNGASDYGNKFGEPVLAGFARSFGQRIPSNERIEYIKPIMFTGGIGTIDDGYVQKNHAEIGMDVAKIGGPVYRIGVGGGAASSTEVQGSEGSESLDFNAVQRGDAEMEQKLNRLIRACIEHQKGNVIESIHDQGAGGNGNVLKEISEPMGAKIHCNKFTLGDPTINTMELWGAEYQESNAILIRKENRAILDKISKREKCQVDYVGEITGDHHITLVENETAQKHPVHLDLELVLASMPRKNFRYQQKQIPLKPLVIQGEDKTRLMIESLHKVLRLPSVASKRYLTTKVDRCVTGLVAQQQCVGPQHTPIADYALIALNYYTYHGSVTSIGEQPIKGLISPEANGRLSVAEAVTNLMFCAITEMADIKCEGNWMWPAKLDGEGALLVQTCEAMCEFMKQINIGIDGGKDSLSMAAKVKLPNGSEIVKSPGTLVISAYAPVPDIRIKVTPEMKIDGCSLIYVKLNGNDRFRLGGSALAQVYKQIGNDCPDMEDPSHLKNGFAIVQKLIKNKICTAGHDVSDGGLIVCLLEMAFVTDCGIDVAIPSFGQDPLNVFFAEECGVIIEIRDENVQSVLNDFKSANIIAHKIGKAIRKKDVVIRFDNTVMILGHMFTLRDVWEETSFQLENHQANPECVMHEKNGLKFRKTPNWKLTFETAKINLNIDSHITSAPKVAVLREEGINGDREMIASFFMVGFDVVDITVTDLISQTVNLDHFRGLIFPGGFSYADVLGSARGWAATLKYNSNVETQLQRFKHRNDTFSLGVCNGCQLMALLGWVGSKSNGTQGTLLTHNTSGRFECRFTSVMIPEKTPAMMLNGMQGSVMGVWVAHGEGRFVFENDQIKKSVKDFVSLVYVDDDNKPTTIYPMNPNGSVDGIAGICSTDGRHLAMMPHPERATLSWQWPYIPSTMEHMKHSLASPWAKMFENAYKWSMATRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMY5</accession>
    <name>A0A922HMY5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box only protein 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FBXO47</name>
        <name evidence="2" type="ORF">DERF_015970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMY5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056622">
        <property type="entry name" value="ARM_FBXO47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038946">
        <property type="entry name" value="FBXO47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34098:SF1">
        <property type="entry name" value="F-BOX ONLY PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24467">
        <property type="entry name" value="ARM_FBXO47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FBXO47 ARM repeats region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="494" mass="58057" checksum="FBED5764BA1E2CA0" modified="2023-02-22" version="1">MIADLKISMMNQSGIKRKFSTNSSSIKQTISETIETDMIVTNNNKKIALLPYEIPLYTGIKDNIDRPEYENDQKQIIGYFCLLPEEIMIKIFRLLSIEELSLMAMTNSKIRNFIIQFFLFSHPGYVFLIRASQFNTIDIYEPRFIFESQKLFSRIGLLIKRSTFLFRTNDRIDMMIHIMEFSYGIPSIRLLSNHDYAHFKLTIKCYSKLMNTFIKGWRDFECEKMFQKLKDVCQIDLQIGKILKNTLGSKQKQELLVRNFFRMIFAHPHDSLNNLKEKIGWLMKTVNVYTLSEMARLFIVIFGPLVTVNNNFHNLSLPYIAWWDLTESNFTERSFEDLGLTLYFLYLKSDEFSYSKDFLIDLVDRIIMTPTRWTAMNVSEMLYYAGYELTLTFFGKKIKEGYIEDVATQLCHLNVVTYKNTKDLTTIAKIIEILVNENGFELIQKLPDAFSAAFFDVEIMSDEDQIEIYEISDIIESQLELMKIALLKCNQNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN94</accession>
    <name>A0A922HN94_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_016067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN94"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036711294" description="DUF19 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="30141" checksum="97A4E1F9BE71F127" modified="2023-02-22" version="1">MINKSLFWIINLLLLSLLITLIAMNSVYAESRYLLKNRTNCTENNLKQIELKVAKMMPIGTFARKLPENFNQAKGFCKESIRLVRETEQFFLHCYKKEMVDLAKIIIYTLKQNIKLYCRKNTKRLAKLLTVAPCVNKHINRADHCIGNFMNQTKQLVGFKNDKDKIKYACCNYVEGMKCARVVLDDVVCSEENNDELIMDSIRGLTGNFVNFVCGDFDETTTLCDQLGPQPPLDKPITKQYYTPIFLLVDLMESMKSFQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP32</accession>
    <name>A0A922HP32_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TRMT44</name>
        <name evidence="14" type="ORF">DERF_015025</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="11"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP32"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="689"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="689"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9494333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="718" mass="85325" checksum="A87BAFA7F4D86C0B" modified="2023-02-22" version="1">MAPDNSFWHAALLYINRPNLLNKRLIGAKLERFWQFPNENYDIEQFLSTPNFKTSIKHLDSIFIICDKNNKNLLNFCDPTNELQHQRPILILRKLFRKQSLKSLLKCSTSSDQSNNIEYDFVCLWPLLNKFIIVPLDVEPGFNVNIRQDENSSHVQINIRNGNDDIAFALKLIDDVDKAQNCDKQNFHLELSFPSLVPNEENGKESQLWLKNVFTNKFERWIRQQRQNVEITNKNNSKHKVKRKEQEKSKNNDKYNNRDNKNLEGSIRNISVENYCENYNRLKQKYVQPLMRIWTTIENTDPIKFIYEDIAIAAYLITLWQEEMEKFDTKFQQRKQTFADIGCGNGLLVYILTQEGYDGYGVDLRRRNIWYLYNNDDDDDKERKKVRLIEMKIDLFEYETTDDFGLPHCDWMIGNHSDELTPWILYMASMQNTQTRVFLLPCCCYNLDGFRFQRTTEPSTKSQYQCYIDFLESLCYQFGFAQCQRDKLRIPSTKRICLICTGRTYLMSLVSDNNIINDSSGEQKNIGKQNDESIESEWQQKRRQIVRQSLQKQNDYHQRKRLRETKEPVRNCTHIDQNIKQEIISRLSNALISQTDNDNDPYDGSSLSFQEAIALLDCNNHNDDDDDDDRDKDRIRKHLKNQCGGLQTFIRNHKFIFTIRDGRIRFQSIDYLRIWNQNKDNDPNGEQMKPTKKDCWFYRNHPRGCPLLANECRFRHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPY5</accession>
    <name>A0A922HPY5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">TOM1-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TOM1L2</name>
        <name evidence="8" type="ORF">DERF_013331</name>
        <name evidence="7" type="ORF">HUG17_6071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPY5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14233">
        <property type="entry name" value="GAT_TOM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03565">
        <property type="entry name" value="VHS_Tom1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014645">
        <property type="entry name" value="TOM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF137">
        <property type="entry name" value="GH05942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036948">
        <property type="entry name" value="TOM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="5">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="6">
        <location>
            <begin position="219"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7643709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9497336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="508" mass="56986" checksum="24F6868CCE23A5DA" modified="2023-02-22" version="1">MADLLQRFSGNPFSTSVGQRIEQATDPSMNSENWSLNMEICDIINDTEDGARDAIRAIKKRLQQTAGKNFTVFKLTLIVLETCVKNCGKRFHILVSNKDFIQDLVKLIGPKNDPPAEIQEKVLSLIQSWAEAFHGQPDMQGVSIVYNELRNKGIEFPKSSNEPKVPIYTPQRQISPSSKNQEIASSPPKYSMQETSPNKQVTSATRTTSELYPLHLSPEQLNKLKTELEVVQGNMKVMSEMLTEMKPGQEHKDDWTLLIELHQTLVSMQKRIMDLIEKVANEEVTSELLRINDELNNLFMRFDRYQKKRGGNNGNDQRTDFNLMPSTSSKLPHPNQKNMKSTNQPSLIDFTDENDEPDLIGGLKKLDMNSSQSSQMTKPSSNNMIISSSSSSQQHVENMGDKEFDMFAQSRSSTTATTSSSIISQASTSSSLSSTSKPLLNVGSRPKDPAPLPSTEEAKKEMEEIERWLNTKPGEPSMSFEAFLEKRANALDKQPLKKTNSNGQQDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ87</accession>
    <name>A0A922HQ87_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ87"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8959" checksum="6E676DA401FBB2A0" modified="2023-02-22" version="1">MNQIFSGIYGENFEHEPSVNERNKIRMIAKKIFNEIIFQNENFYDNGFDQRIKSYFDSIIDNINKLIKKDFDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HR91</accession>
    <name>A0A922HR91_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HR91"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="396" mass="48260" checksum="54211379B0C12E24" modified="2023-02-22" version="1">MENSQEITSISTIFQMYFKHSQIYNQRINYSMYEYQTHSIPFKKRCAKTVYHFISTMYVAFMLIITQTKYIPSLRFIIKIQNEMTGFDMQLLSSFSAATLLLKEYKWYTTVRQLLEYRYPLNEILIKYGDTIGENLDNHNQLLLVKYFIRSNRFTKKLNRFFRLGFYFTTIKMIIMLMEYVADEKIDWNQFFIGAIFTIIMFININHFIIGFSMEMIYLIFSLGYLTSYMKQLIDEMKQWQSIWNRRMAIFQYNIRRQYLRHYNEMINFNNMHCNFLMFIEIMSKSLVLIIVIACGKTMNLSINNFLKIMKNSLKCFMIGMQKINQTYSYRSNISSFKRIIYLRETIERNLFLQTITRNHYGFYFGQIFFIDKMKLVEMFMFNFVFFTMLYKKIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRP0</accession>
    <name>A0A922HRP0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRP0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="323" mass="36876" checksum="B035F9F27C74BF6F" modified="2023-02-22" version="1">MNYLKKKITKVVGNPKRKNDDDDDFDNYVPEIPPHPSTLTTTTTTTDINDQLKIKFDSTNTNFANFDSVNNITVGEPFPLSFGEQEQQQQQEQPKLSLEELKAKEEEYRKEEREKLRQQEESKKDCEEWKFFLSLTAKADAVTSKTQTVLEKLQTESAVKEISKFEDPTFSDQFDETAPKNIGAWAAFDETADYNPSDPIFQFPKQDETEQQQSIDKDKTKPVIDEETKRIARELIEDFGFTNPAPGIPLVDGEKTKTDTSLFAIEEPTIDPFDTSFIDVEAIKSGESILKPTLIKDIDVDEIDPFDTSYIESTIQKDLAIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRP1</accession>
    <name>A0A922HRP1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRP1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="394" mass="47530" checksum="13B63C554ECAB2E0" modified="2023-02-22" version="1">MRRNKNCDPSKDNVMLNENENENIDLFFRFYSLLGISLYGYEQSKKSWILSFSFILTSIWRTYFIITSSFVLYSHGQMFIEFYSQFIKSIKTQPLLKFSFVWSWRIKNLFNFVLIILFIFNGTKILKCFNSSILFKYDHHIKISKSISIRLLGYMSMFAFIVWFIYKQFHQINFLHLLLVSHMYFGYTYMAFFYDLHFLMFSLSKRTFDILIRKLSEIDDNNLTKDDSFELINDIKALGKTLYEFNRMCSMTLFCSVIDTVFSYLNNIVFFFGQTKFHGNEIFFFHFFMNILRSIFICILSWTSQNVINRFDDIYYELLDKSIETSHNYYSKYQKHSKAISLSNAFKIHELAVYRRHFKSYYFYEILPMCLGSLGHICIFIFQYMIIFIQTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRS4</accession>
    <name>A0A922HRS4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acrosin</fullName>
            <ecNumber evidence="3">3.4.21.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DERF_013535</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.</text>
            <dbReference type="EC" id="3.4.21.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.10" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRS4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF8">
        <property type="entry name" value="ACROSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="15">
        <location>
            <begin position="194"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="17">
        <location>
            <begin position="403"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="16">
        <location>
            <begin position="530"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9497558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="793" mass="89696" checksum="F010802EEA5A4949" modified="2023-02-22" version="1">MDKTDKTNDQQTQSLPPQQASSSSSAVATAATATASNDILMSEKQCGSILNSTPVTGDGGGGGGCDGSINQPTTTTTTTIITNNKHESIQLKPRMSAKLPPHHHIRGDDTHEIENANTGDNLKSSRRSYYSDSSDRAKLPLHQRLVAYLRIKSRLLSCSLYFLIIFLSLAVLFAVAIVIYYILTIYYHRQAISIDTDSCIPMRVTLCQKFNVQYSYTKLPNRFGQIDQSIINDKLTSTYSTILGIKCFTLLPLFLCSQLVPRCNSSGHAVPMCKQICKESIHRCSFFLDIFDIEWPDEIDCDKLPDSNDPDICVGNRQAMELNQLANRHICKENGFRCDQTRCIPPNWKCDGYMDCNDSLDERHCNECRDDQFYCSHGVCINRSNICDGKPDCPDGRDERQCFRLSDAMGLNGQGKLQVWNPLLSQWDEMCGEDWQVPEQSEEVCRLLGYQSSNETRLQDETSVIRSRYLPPKFNHGRSNFSPKRIRFSSLLNRDDKCRDSDTSVHIKCHNFECGRPSHFHQRRRRNTRIVGGEESYPGKWPWLVSFHGGPAEVFFCAGVLISDWWVLTAAHCIGTKNNTSGWTINLGVTRRTSTPLFVRQRQVAKLIKHPGFQMSVDYYYSDDIALVLLKEKVEFDEFLRPVCLPANSSVEVAPGTKCMVIGWGKKIHDDYADYQSAIHEVEVPIVSHRKCIQWYAKQLPYHPIPTTMVCAGYEQGKKDACQGDSGGPLLCYNEDQSWFVAGIVSWGINCAQPQLPGIYTNVPKYLNWIKMTTNEHEKPISIDNNLDYLMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HST4</accession>
    <name>A0A922HST4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ARL4C</name>
        <name evidence="10" type="ORF">DERF_012801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in apoptosis. May act as a tumor suppressor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HST4"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000898">
        <property type="entry name" value="ADP-ribosylation factor-like protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9501998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="216" mass="24938" checksum="9EDF9FAE61363A18" modified="2023-02-22" version="1">MTIMGSTFSKRLQSLIESLPFFQTLHITMVGLDSAGKTTALYRLKFGQYINTLPTIGFNCEKIRIDFKKSKGVSFTIWDIGGQDKLRPLWIPYTRCTDGIIFMVDSVDDDRFEEARIELMRTLKFPQNAQVPVLIFANKHDLPNSKNPDEITQALGLNDLNGKHLWHIQSCCSITGDDLEDGLEHLYEMIIERRRMQKLNPNNHFHHGSNNKRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTN8</accession>
    <name>A0A922HTN8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTN8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="6780" checksum="1BBA0053B1CB5586" modified="2023-02-22" version="1">MNILSNGINNLVCVQIINVLCCMFITYTSHTTLGTIDIFMTVIHTNCGCLKGFINKSIKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTN9</accession>
    <name>A0A922HTN9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-terminal acetyltransferase B complex subunit MDM20 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NAA25</name>
        <name evidence="5" type="ORF">DERF_012234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTN9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="868"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9501386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1008" mass="120348" checksum="B7533EADE1975C57" modified="2023-02-22" version="1">MSRQHQPQQQPAENDRKLRPVFEYLDNGSYKKALQEIDKLLKKNRNQQYVRALKSLTLVRLHRRKESMEILNELHAEMPADEMILQTMSMCYREIQRNDLITTLYENALKKDSTNEKLFAHLFMSYVRMNDYKKQQITALNLYKVHQKNPYYFWAIMSIYMQAMSADDETMANKIILPLAEKMCEKFYKENRFESDSEYDLYLMVLEAQKNYSRMITIMEEREMKRKINKKSTDHFNYQLEQKAKLLRNESRLIECFDCYERLINDNNDQYEYYIDAFTLALQLDDQQRDSNSNTESLHMVRLLKLMQQMCIEGKTSVWKMYDEDKQQSNDSLHKMVTERCPRSPFIARIIIFSKLLNDNQDNHPLFQHYIQENPLINPIDLCVEYFENFGSKYVCIKDLIFILKNIKMERNKINELLMRMKFLVTKLNDDDHHHLVSDKNLNMSLCYNYIEHYCQEKFIENINDRRRDVDNFINNNYEQQHFTNNSSLIYLIVLKTLANTDIYQTNIDDDDHHQCLSQTIFDLIIIIESYLLQNRNDFYAKLILVCLYNAIGAAFSSLNLYELMEIKLIQNETLGYHFFPSSLHCALFQKAQQFLNSSYKFYSYNFKEASDSILTCYKNGCFAKIEEILNFNSKLKNSICYHLTFVERFFNDLLLDCKSENSFSQFAYILFLEIFRSKDFVIDIMKICDNRDLKILNPYHYQMDLYVENVLKKTTLEQEKQWLLYRYNVLKMIALGHFLSKKLWSDDCVLMNNNTNKESSEITNHVNHDDDDNQTDFDHLNVEMFENLLENSAKQYEYCMAEIQHDLKYCIEGPQPSRLITFFDHLIIMKKILRFKMKICSTNCLKEIETVIDEWKCNQTMKGAYKLLGRISVWIDVLNIAVSLFSLIIDGQRRLNKMMKKLKKRLDVKKFQDVEQFSNTFAMAITSMYMNIDGYFKSIITIIQEVEIIPMVDSYEYKFSEKFNISDTVIDSVRTNVRTSYEKSLSEMLQILQMKQKYLSSSMNPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUL6</accession>
    <name>A0A922HUL6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MIC10</name>
        <name evidence="11" type="ORF">DERF_010629</name>
        <name evidence="10" type="ORF">HUG17_9718</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUL6"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7643027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9505858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8284" checksum="29C7175E88842127" modified="2023-02-22" version="1">MSVTNQNVKSDMAICQKYDRFIANAIMNTGIGIAAGSLASLILFKRRVWPIHYGIGIAFGYSLKDFEICLNQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV30</accession>
    <name>A0A922HV30_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chitin binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">Cda5_6</name>
        <name evidence="3" type="ORF">DERF_011265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV30"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052740">
        <property type="entry name" value="CE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45985:SF12">
        <property type="entry name" value="CHITIN DEACETYLASE-LIKE 5, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="601"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="920" mass="104710" checksum="23503ADB4C699E50" modified="2023-02-22" version="1">MNPSTNSKLAVDHRQIRNSSIGSSSSNHPRYQPIILVERNRLLIGDSFIINNNSQNQQIPASNPPTTASIIPKHLQLRRQPSTTTSIDNENENLVVMTTPTYRKLKFKRPHLHHHNRQHLSQIINSNITSSRRPSFQEIILPQNHLITSNEEIIVPNDNENGVVDDGKDKNKKTATMVTAKYVSPSLNIMSPANTITIFSKFLWSFNVTDKPYEDRPPSSASQSKGYSQTVTDRVNVIPNENNEIRDPRPQSTETTINIIEATPLIGVDNNQLTLAVRPLFAENEEFDILRNDISKSNTAAKHLRRSLPNFLPSNISSAFQSPPNFRIQSASFGRPAPKPSSYHWSYSAPINLTSRYKAKSLSTITSEHLQPQSFTLNNDQPFQSFITHSTTRKFSTAVTPRTNVPVTSMNFHHHQHNRNQPFDLSYGARPVMSSPRKPNTNNAIVAQQQFISTPLMTNTTSTTTRRTTTTTTTTPAPISITSFSRTAINRNYNDNHRHPISNYDYDFSDDHFYHNYGIAASHSVVTSTTTTPAPSRRQMTNKLRTSSLSNLKNSKTDIVVTRGGGRTNAERCTEESCHLPYCRCGSSAIPAGLKPKDIAQLVMITFDDSINELNWDLYQDIFSNRFNPNGCPILGTFYVSHEWTDYSQVQNLYSVGHEMASHTITHSFGDKFSKEKWLNEVNGQREILSLYGGVQYEDVRGMRAPFLQPGGNRQYEMLYDANFTYDSSLPVFENNPPYWPYTFDYAMNHECMITPCPSKSFPGLWEVGMVMLIDHRGGRCSMVDACSHPSTEDGVFENLLKNFNRHYHSNKAPFGLYFHSAWFNTAHHKNGFLRFIDHIGKNKDVYFVTKWQLLQWMMQPTPLIRLKSFQPFQCDYSDRPACRQPKVCSTSHRDGPRYLKTCQKCPKHYPWVGKTGFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVT1</accession>
    <name>A0A922HVT1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVT1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9507134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="387" mass="45041" checksum="A173E03699908A2F" modified="2023-02-22" version="1">MNHFLPKKPNFVINQIESSSFNDVINNTTTNVISNQMTNLSWSFFEKFIHQLSLAYNETCHHWYDDNDRLLSLTATINIETSSYIDLIPHLQFAIKNDTNFTFDDNYLLLNRFIDSINFEISKRPLELYTMFQPLLFIIILIISIFYKSSFIAHNLYFLAFESMVIILTDGHDSSMFASYYESFIMFFIFCLSIYIAIIGFSFFKQKSYKICTVKIDDIIDSSSDMISIESSLYNHDNDYSISTEMHADGESDLEIMDNQSHMEMEHIFDEQLLMRSTPIRELFINHRHLFPPLFVHNEYYHPIPSDCCSSISSTSNLNTTIDSKQTNESIINRIHSSNIVRKMPFKSLMEQSSNTQSLIKTDVSTDHDDDNNINSFIIVDSDGEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW26</accession>
    <name>A0A922HW26_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_010905</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW26"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="15">
        <location>
            <begin position="121"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9506162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="601" mass="69018" checksum="33994A29876D17A8" modified="2023-02-22" version="1">MAININNQQSDHIDNHDNVNGNVSDMDQGYCHQQHHHRVSSSPLTIRKKLMTQSTHEIPTTTTKTTITTTTSENFLAKIDRSISSSIIMVENDDDDIVGDPKLIGYVYVSLYPVKFFTVPWIALLGVAGGFGVSIGAHRLFAHRSFKARWLLRFGLVLVETLSMNGGCYSYARDHRCHHKFVDTNGDPKNAKRGFFFAHIGWWMLKKHPDVIRMGRKLNHKDLDDEPLIVWQKKLYFPLFLLVSVVGPTLIPIYLWNEDIVISFFMSAVLRTVVVVHHLFTVNSIAHIFGLRPYNRDIGPTESKITMYLSLGEGSHNYHHTFPYDYANCEKKWWEVFNPSTLFVDMCSMIGLAYDLKKPSDRVIKGVVSRVGDPRFYEKKLTVQKPMRKRIMHGATDWLIGTVVAGWAIYPPILFKIITGRPLIINNYSPLFQSRRRSLPKFGTNSMDSLEVIINVYSDRVLVRNRSLIMMMEDSERIDDQLFEWNSKTISSCFVLREDKRIISVVAFNPENLQMEAYVFYMADRFIVAQLMNILYKMLVENFTTINGGHDGNEDSNSSTDSLCDNHQKPIKLLMTMVDGRQKNIPNNHHSSSDDIQLINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWC0</accession>
    <name>A0A922HWC0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7041 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWC0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="69"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9510643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="353" mass="40230" checksum="4A547748F96CCD78" modified="2023-02-22" version="1">MDNNDNANDTLMSETGEQANQVDPALIASLLQSMHSMMIEMKRDRDTLQAMVVDMRNERRSRPASNIDMPPFIDTDPRGWLEAVSACFNAAHVNDEKDQFFKIVSQLPKTIRDNLKHKLDLTDYTDGKLASLKELIIREYELSETIRRDRILSRKDLENQKPSVAWSWLLNMGKNVFTIVQLLAFWEKLLPKDIGLSIHHVIVPIERQLTENPNDPQVLQSIAGIVHMADSLIEKYGITTNNHQVSAISRPRTASTSNNNNPNSRNIRKRQAFRDDGPYCRNHFLYGNRANRCGRPQSCTFLSRSNRSNQSNNQSNRFNNPRSNTPSRSQSPNPSQQQQQPSSTTTTAANQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWP5</accession>
    <name>A0A922HWP5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">UBL3_1</name>
        <name evidence="2" type="ORF">DERF_010271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWP5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17048">
        <property type="entry name" value="Ubl_UBL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047977">
        <property type="entry name" value="UBL3_Ubl_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="1">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="135" mass="15043" checksum="1244C7A0D6B69882" modified="2023-02-22" version="1">MNYVIWKKMADTIPSDKINLRLIMPAYGESGKAKDFIFSPSDSAADIAQFVFNHWPDDWADQAVPKPEILRLIFQGRFLHGNVTLGILQLPLGKTTVMHLVPREHLPKVNSQDNCPKSKDRSSGCCSCLGSCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWR2</accession>
    <name>A0A922HWR2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FAXDC2_5</name>
        <name evidence="7" type="ORF">DERF_011249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWR2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="228"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9506522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="380" mass="45371" checksum="DF71B53D03C73A64" modified="2023-02-22" version="1">MVPISSCIERLRTLDRVERIDCGRFERLLSLDRFQFRQFQIDLHQNLRLYPHNHHAFLAIAVKDFRFLHPFACVINYIYIRGLHFGQTIAYKMETINLTIDNITEPYRLAVENHYESFILHRFNGDHKFANSLIGLFITIPVYWIVGTAYTFIDIYQWPKFILKYKIQMDKSQVNGKDLRRLVKQVLFNQILGISLGVSFQWLQVNHILIPQSSTRIPTISRFITEWISFILIREVLFYYTHRLCHHGYLYRHIHKRHHEWQTPIALAAIYCHPIEHAIVNTFPVLIGPYLMQSHLLVSNLWLLYTVLLTLNDHCGYHFPWSLSPVFHDFHHLKFNVNYGILGILDWLHGTDKIFRKSKYFQNHRIYFGLTPPSDYSKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HY74</accession>
    <name>A0A922HY74_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fat storage-inducing transmembrane protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FITM2_1</name>
        <name evidence="10" type="ORF">DERF_010238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HY74"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9511811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="476" mass="54295" checksum="7B75FE91C5494B4F" modified="2023-02-22" version="1">MSRRTNRSHRTSAYSSSSSSSSSSSSSLSGFNNGNNWLKFSNTSVTWARSRQQRSDSLAQNSTGIETFRRRKIFNASTEFIHVVSLILMSLCRQVTNRSLLQRRMIIYLFLIFIGGLLKDFASLIIRALVFSLSSEHFLNRYFVKLAWFWNTILLVPLIILSSSTLYLLDSIQLTDVDKSIEDYHERKTNTPLMGVGGGSSTKTTSQNSSLQTNGTGTKQTSQIITLQSSSQNQNQSQLLIEQYQQAILAQADQCQQCQRFSLRWFGYSAQKIIQIAMVKDMIRFIICSGFYLASISIFAMIQFSTTTQLATVSQVNVTTTGGFDISGHVYILIFSNLMIIEECTIMTGWEPLGDRLYALSVEFMNIVIGSQSPTLTNNIEMNRKLYLSWSRYRSHSRKLRLIFLAITLLSIVWDFMLMQTIFFYHSLIEKLLAMLWAFIGWYVCYRFLFPLLNIEVRRVSIVKGQNSNTNTTAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYG5</accession>
    <name>A0A922HYG5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_006998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYG5"/>
    <dbReference type="OrthoDB" id="6488802at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052729">
        <property type="entry name" value="Acyl/Acetyltrans_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH/HolE_GNAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237:SF1">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9516244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="316" mass="36397" checksum="9465642548AAD948" modified="2023-02-22" version="1">MMDDFVVKINNEGKCILITICQMLSQHIDGAVECFNDNFDVFDCPSTVLAFFHQDPQAFFIAIENESQKVIGVCGAPRCSQQTNFLGLYGIRPEYRSHGIGSILFEQCLNHIQDHNVGLYAVPNMIQKYITKRGFRIREHVSMVNFSGVPKRISQSNRTNIQIIQLCTENIEKFQEKIIKYDEKIQDTSREKLIKFILQDQSYRTCMALDSNDFSIQGFGCLRQHSITKRFYLGPLYSDDADSAQLLIESLIETNFSSIQANGMIWNAIDANQISLDLAKKFDLQEIERCERIFTKHPIRANYQFIYSVFSPDFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYJ1</accession>
    <name>A0A922HYJ1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">IQ motif and S7 domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">IQSEC1_1</name>
        <name evidence="8" type="ORF">DERF_010057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRAG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYJ1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033742">
        <property type="entry name" value="IQSEC_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF342">
        <property type="entry name" value="FI21420P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16453">
        <property type="entry name" value="IQ_SEC7_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="87"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="505"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9511609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="551" mass="62520" checksum="E6FCE91BFA85E8D6" modified="2023-02-22" version="1">MNTNMVANTNVQQQYSNQNQQNHKSQGGQVLFSNNIQYMNNNNNNSSISSSATTESLLQHHYHHGHHNNTAATTAGGGGGTNADIYRKRLYRVGLNLFNKQPSERGIRFLIANNFIEQSVTIEEQARAVAIFLITRKGVSRQMIGEYLADNNPFNKAVLKSFVAEINLTGLIVDEALRSFQMNFRFPGEAQKIERLVESFADRYKECNPNDVLSRDSIFILAFAIIMLNTDLHKPTNIKHRMTQEQWLSNLKGVFSEGDLSSQFLLGVYKRIKKQELQTGPDHVTQVLKVQSTIVGKDVPNLCLSHRRLVCYCRLYEIRDVNRKEKVGQHQRDVFLFNDLLLITKTTNRSRNNQMAEYQYRSSTSLDGLQVNIFAKGFYAHGIRISRRVDQKCLALFNARNELDQKRFVEDLRESIAEMDEMEQIRITKSSSLVQLNDFMLTTTTTNNNNAIMASSSGHGTYHNNNRQQSISSSNLHSSNGDIDGNLATSDSTINDVDIDDEQNKQQQQQQPQSPNGSGPNPSTTAPTTTTSNGHLVQHQQQQQQQHYYHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYR4</accession>
    <name>A0A922HYR4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Activating signal cointegrator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TRIP4</name>
        <name evidence="4" type="ORF">DERF_007843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYR4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06554">
        <property type="entry name" value="ASCH_ASC-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.30:FF:000006">
        <property type="entry name" value="Putative_zinc_finger_motif_-_C2HC5-type /ASCH_domain_containing_protein_-_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.30">
        <property type="entry name" value="Hypothetical protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="3">
        <location>
            <begin position="24"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="ASCH" evidence="2">
        <location>
            <begin position="317"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9517149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="454" mass="52068" checksum="A606DC69E82A3327" modified="2023-02-22" version="1">MKNKKKNQFIQIVDESGTFLLDGRRQCMCEASKHELINNCLNCGRIVCQQEGSGPCFTCGTFVLNKQERDQLLSGSDEAIQKVQQLADSGARLDFMDQVASCLNTKKSLKEIAASLTNDPNLDRAIEHKNKLLEFDKKSVARSKVFDDQVDYFTIQSQNFITEQNRQAIANRVDYIVENKFNKIDKIAIDFNNLTVSDYTESVIENIDDEHRKLEELSTITTDYELKPSSYFIDNDDKTMDKKSLPPPIYVPSQDTIDGHDKNNGGNNNNKNRMKTTNSNHSNKSIILPKMVSKMNEYEHRVQDTEMAKIDDHGMCLAIRQPYASLLVAGIKRFEGRTWYSPFKGRLWIYAAHKMPSDEEIQNVEQFYSHLGNKNFPRNYPTDVIVGCVIIEDCLPEEIYRKQYPECEIESPYVFVCDYPIAFMRPLPVAKSGGRQIYRLEPKIHQACKGLLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0F1</accession>
    <name>A0A922I0F1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_008681</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0F1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9518079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="742" mass="86613" checksum="050BD282284D87BB" modified="2023-02-22" version="1">MSYYNQKNYWSSPLWPFYSTLNINITIRSSFSHRKFVILLFGLIFCHSTLCLSHMITDHHHHHNYDDDEYLNLRKEFPCGHIPPKLNQIRFVHINHHHNRNKRNEQPTINHHQNLRIKYFYDESVEKITKEKYLIIDKVVLPEAISYWQQALFVKPFHVPIKLNRRCIRDNPDFLVNQDYCIEGCEQHTLCGEVVIPDEHLEDCVVCDEHGRDCVREKPSGTNHSLINGIQDADFVFYISTLQSVRCGKGSTIAYAAHCQQETTLNRPIAGHANICPDSISTKPQDLETLISTFKHEILHALGFSVSLYAFYLDPNGLNPTVDAFKKLQNKQQTLANNRSTFNGGGSMLMISKKILQRVPRKNWMVRGGNITNNVFVISTPNVLREVRNHFNCSKLEGAELENQGEDGTLLTHWEKRLFENEAMTGTHTQNPVYSRITLALMEDTGWYKVNYSLAQPLEWGRNLGCDFAMKSCKEWMDTKRHQGKSIHPFCDRVKKDPLQTECNDNRDSVALCNLRQYDQKLDRKFQIFDEIKNVSQDAVSYYGGSVILADYCPYIQEFTWKQNNETVRGSKCSFPENNPSIEKNFALEHYGTNSKCMNHGDEMWVERTCQEIRQWQHWGSGCYQYRCTEDGFLSIIIKNHTYVCMFDNQEIKIQLSYNNWLHKGSIICPKCTELCSNCKQLDPESLERLKNETIYDRDHLKCSATTPNYFKNYSYFLFFIYLISSVIITHFFFTTFSHSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1B2</accession>
    <name>A0A922I1B2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein TSR1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TSR1</name>
        <name evidence="7" type="ORF">DERF_006995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required during maturation of the 40S ribosomal subunit in the nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1B2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AARP2CN" evidence="5">
        <location>
            <begin position="238"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="6">
        <location>
            <begin position="490"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="394"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9516241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="815" mass="95602" checksum="F6A603CB7EC4D1F3" modified="2023-02-22" version="1">MEQHRPGRLKQKNKPHKAGKKRVRFHSTSSVNSLRSSSTCVGGKKGSGLARSVRKNQLIQIRRLKREEIINSRRKISIAPILIAVIDLSDRLDHFAKLLLAFDQTATVEISKHGHYWHIDIPKFRTRYQLVNLDRKDLYSSIDLAKLADILLIIHSNKVERFEVDNPELIQDDFFTLDAIYNHCLPLTIHAIIGLADVSNPKQKDRVRRTLFEAINKNFPGLMNGGNDKMRSLDTAQDLIKLFHYCSTVKCCRSRSRSYCSRRSQLLAEDFHFVPNSSDPEIGTLQVEGFVRNNPFNVSSLVYVPEFGEFQMDLIETVSVPYGDKKRKQNKEIEFRSQCDLQLRPSLKRENPVQTIFEEEMQAQHEDKKHSEIEKKKVPIGTSDYQANWIFESDEEENDDDDDVECDNESQFSDDQDEIIEKIKKIQFAPIDNASDDDDENVNGMKDDNEKDDVSLDKDIDYDQEINMQDEQMELEKFKEQRMYEMFPDEIDTPVDRPARERFAKYRGLKSFRTSQWDCKENLPSDYSRIFQFENFNRTRRRIFKSDTFGADPGFYIRVHLANVPRKLSDYFQQNSHKPLILYELLAHEHKMSVMNVVVKKVPSFTMPIKSKERLIFHVGYRRFVAKPIFSAHTTGDKHKYEKYLRSDVACVATLYGPITYPPAPVLVYKEFEQDGSHQLVAIGSLLDCSPDRLIIKRYILSGHPYKIHRRHSVVRYMFFNREDILWFRPVELRTKYGRHGHILEPLGTHGHMKCRFDHQLSSQDTVLMYLYKRVFPKWYYEPITIDQHPNIHLTSNDQINNNNDDDDDDHRMQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1I2</accession>
    <name>A0A922I1I2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1I2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="86" mass="9650" checksum="45750D7012543C40" modified="2023-02-22" version="1">MAICSDFFPALGVVARTDVIVLVFATHINTTGIQNLKLNYQSSSSSTTKTTTMGNLMIKYSQETKIKDFQERTFLMNSISLKTIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2E3</accession>
    <name>A0A922I2E3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine and histidine-rich protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CYHR1</name>
        <name evidence="9" type="ORF">DERF_004901</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ZFTRAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2E3"/>
    <dbReference type="OrthoDB" id="10062218at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16505">
        <property type="entry name" value="RING-HC_CYHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039338">
        <property type="entry name" value="ZFTRAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23059">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23059:SF4">
        <property type="entry name" value="ZINC FINGER TRAF-TYPE-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="268"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="8">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="5">
        <location>
            <begin position="338"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9521227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="562" mass="61914" checksum="BB60D62CA68B3EE5" modified="2023-02-22" version="1">MSTDVLNSNAATANAVPTVDNNNGTSNTSANNSSNNGQIESTNSSSSSSSSSSSSSTASTSNTTLLATQPQQASTSMMGAPTSVVVTISTQQQQQQQHQQQQQHAQQGPSTSSQSTSSLVAGPSSQASYVGIINEIPGTSSTSMQYLTETATYLHSVMSQGQTQTSHHLIHPIQSSSSSIASSSGSQSLATETGVVTQNVHHLIKRPFESNMDKLLTADDSCGSASSSSKRSKMSSSSLSPPPSKLFDADGLTMRQKLEQRLNGILCCAVCLDLPRSFVYQCTNGHLMCAGCFTHVLADARLRDESPTCPSCRVNISKESCSRNLAVEKAVSELPGECRFCQRELPRSMLEKHMTEICEERIVPCSFSNIGCPWNGPFHEAAYHANDCSHPNKSAREVLAHLENEERRRCEQRRVHETLFTLLSYEKIAFHDIQFRPYRTDEYIHKLFYETSRFTAFNLQWVVKARVNDDQRDPTQSCQRHLSFQLCLKSKINNAMTIHYMLLKGPLGEAKVLPMIYKFDFNESQTESNYNCINLASTNADSNRLLAERTINFRLIMFQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2K1</accession>
    <name>A0A922I2K1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Solute carrier family 43 member 3-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2K1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027197">
        <property type="entry name" value="SLC43A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20765:SF1">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOBASE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20765">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 43 MEMBER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="72807" checksum="2E70C42A81C563B3" modified="2023-02-22" version="1">MTLSMDSKDFLPNNNEDDDDDQSSCNKKPMATTTTTATTTIDTTVNNQDEYQKAITPRPIRYFILISTIIESIIFSGLIFGWPALFYMLKNEQIYSHLCSSQNDDNDDGQLSILFDDNNDQFNNTTIDSIFFVDDTDNNKLNNNNGHNCIPQENILNMAFTIGIFSMGFTSFAWGFLLESKGLRFVRMALNFLISLGCFLLSITDSGLVGVPLRIANMQIADFFPLKRSTIITLFSGAFSASPVIFVLIKYGYDNWSLSYFWATFTLFITSITLLPMNTFCLPRLSVRTREKALLKRFDEYRMKIEALDMEMNKKKPHFINRKMIKTVSDRIDEQESGKLLIQSIDGINNSDNDNNNNSKNGTSNNSKKPIIVNFSQYQREKEAARKPGLIKRIFKPVKVSGEENELPLRVSLLSVSFLMHQLWFSWINTYMVLYSGSMALWLDRVTDDDREKGLFTQTFGLVQVSALIIAPIAGDVLDRIVRRAKDVDDGNRRRLLQAQSGFGPILFTTLTLLGAVICRFFDTSIAVYTSIVFITILRALFIAVASAYLRVRYPACHFNRLNGIMCTIGAFFSLLQFPLFYFESKSDLGAFQVNLVCAILTVLCLLNPLSLRIGHLQQYLINKEQNYGQSLMMKSTKSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I319</accession>
    <name>A0A922I319_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I319"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="86" mass="10201" checksum="8F20BB5E0895A063" modified="2023-02-22" version="1">MLRSSNSDLIKKILRNFYLEKYDEHRLKIFTDKYLTKQQQQRKKNQQKVTKNQRINRTTTTTKILPSAFTAFTIAVVVAVVVDFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3M2</accession>
    <name>A0A922I3M2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3M2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="118" mass="13999" checksum="9C64BB2C6C3287A9" modified="2023-02-22" version="1">MILDLMAWEIGVTNKDRLKETEIEKGRKYELLANELEMTYHAKVFQIPVVITWDGLVTHHHRKHLQKIGVDKRLQAYLQYITIKRVLIDARAERPCHDKDLNELFDVAEQQDENLIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I455</accession>
    <name>A0A922I455_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine/arginine-rich splicing factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SRSF1</name>
        <name evidence="11" type="ORF">DERF_008301</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I455"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12601">
        <property type="entry name" value="RRM2_SRSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000053">
        <property type="entry name" value="Serine/arginine-rich splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="107"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9517651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="346" mass="39626" checksum="6D41451F9B1FB8EE" modified="2023-02-22" version="1">MSRSRCRIYVGNLPPDIRTKDIEDLFYRFGKITFVDLKTRRGPPFAFVEFADSRDAKDAVYERDGYDYDGYKLRVEFPRGRERGPGGVFKSGSSSSSRPPPARRSSYRIKVTGLPSSGSWQDLKDHMREAGDVCYADVFKDGSGVVEFLRRDDMKYAINKLDGSKFRSHEGETSYIRITEDSSNSRSNYRRGSRTAYGSRSRSRSRSRSRSRSRSNSRSRSRSYSRSRSITPAAKRSRGSPTYSPPARSRSRSRSRSSRSRTPSSRRSRESRSRSPEISTNNNKTSNGHNRHSRSYSRSVSYSRSRSRTPNDNYNRDRSRSRSRSPDSSSGERTNESSRSIRNEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4B6</accession>
    <name>A0A922I4B6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">TRAFAC class myosin-kinesin ATPase super</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">Myo22</name>
        <name evidence="16" type="ORF">DERF_008877</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17208">
        <property type="entry name" value="FERM_F1_DdMyo7_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051724">
        <property type="entry name" value="Actin_motor_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049">
        <property type="entry name" value="AGAP003327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049:SF5">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 10" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="15">
        <location>
            <begin position="15"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="14">
        <location>
            <begin position="1335"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="13">
        <location>
            <begin position="1488"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="12">
        <location>
            <begin position="1490"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="14">
        <location>
            <begin position="1930"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="12">
        <location>
            <begin position="2120"/>
            <end position="2457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="10">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="799"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="963"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1011"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1063"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1249"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1567"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1892"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1965"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2477"/>
            <end position="2497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="979"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1012"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1029"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1091"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1117"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1249"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1567"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1577"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1969"/>
            <end position="1985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2479"/>
            <end position="2495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9518288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2592" mass="293246" checksum="19079C3210230BE6" modified="2023-02-22" version="1">MVCENDEPVGNRSMDGVPDLTLISNIDEIGINENLHVRYNRQQIYTYAGSILIAVNPYEELDIYESEWQQMYCGKRLGDLEPHVFAIAESSYRHLCSDDADQSIVISGESGAGKTESTKFILQYLCSVTSSQSSWVEHQILEANTILEAFGNAKTARNDNSSRFGKFIQVCFDERGQIGGCVVRDYLLERSRIALQSAAERNYHVFYQLVSAARRDQELAKQLQLDDPAIEFVYLNQSGCTSIEGVDDAANFDSLRLAMSVLRVPETMSDGLFAALSAILWLGNLEFEEQAETERCRLTENDELVISTVATLLGVDAYRLTLITLRRQISVRGTVTDIPLSLREARENRHAMAMAIYSRTFAWLVRHINACTLPDQCAKRFIGVLDIFGFENFQYNSFEQLCINYANEKLQRFFNHYVFALEQQIYHDEGISFEHINFTDNTPCVELLEKPPKCVLRLLSEECKIPRGTDSSFVQKLHSEFHQNHQYYVRGDDRRHWNAQFGIKHYAGDVMYQVADFLAKNKDAQQDQFFEIMLDSNNDFIKSIATLQDTTESIYGTIGRAQDGKGSKGRPLVADAFRQQLSALVDLLSATCPWYVRCIKPNLTKSSRAYDVAQVHTQLRYLGMLDIIRIRREGFPAHYKFDVFIARFRCLLLVKSSHHHHHHHQSHHVPHLKPNSASTRELLNRIRIEPIQWQIGHSKVFLKAGAADELEERRTLLRERMVIRIQSAWRRLICMRLYRCQRSSAIIIQRAFRAMRTRLLYQRQRRAAITIQAFVRGMFAREVARALCHMRAIEAAEKLQRERMERQQSSEENDGTDQQQEQDRMAVEQINGHFLGKRRSSTPDELDELERQLRADVERLYCRNNNNNNNSNYEEILVEETEQVNNTCDTNNNQVDNHTDDELHLKSLKESSVDEDSALESMSSLPPPPPMPLIGQKIGNQPNRSISDQFDQLIQKTELAVDSLDKIQKMNPPKPKPKPNMSAYHHQQQQQQQHQSSLAEKLKAILIVDETQQQQSDDQQQGKMHHHQPSPSICSVDSAVSDSPATSTSDTLMMVANNDQIVHSNGVDGGISQSNDDRSSTASSSILDNRGSISSSEHTGTNTSQRDDVMSVMSDGAATSNSTSDFENSSPLPGSATFHQQQQVHVPLTIATAVPAPTMVPMATAAAIAQVHHQQIYNQQQQKKLIQPQVLSQQQQPIYNGQNQMTMIPVTTTTIAAQPNQQLHQLTPQQIQAITNSKFITKQIVHQQQRSQMPMTTNGAVSSLNGEPPTEWEKDFELSEYASKHLNRHKRDDYSGALSGSSGQIVRTLNRNKRKGLDVNSAELFLTPIEMITWTSSSTIPTAHVHLAIPQNINLACSIFKELNKYLAGEKKLETEIRFIQSMIGHGIEREELRDEIFIQLVRQSNDNPSKEQTIRCWSLLALATAAFMPNKQLSRYLLTYLRRHLRANNTSIACYAQFCLDNLHVGRLSARRFPPSIAEVKAVTALRSLVCRFHLLDGRTKALDLHPADTASDAVLSLAAKLGLRNIDGWALFEVAPEGERVLRSHDYVADVLTLWELRARSESKSTSSSSSASSNHHQSTTIPNSPSVDSIATNCRFVFKKRLFRNANEIPRDTVEVSLLYAQAVHSVVRLDEFPVSERIALQLAGLQAQVLMGDFVEGRIRSYEDVENYISARVRRAAGHSSMEWAVKIADAHRLHGYGKSSLVAKVWYLSLVMQYPLYGAALFPVQYKGVLAIFGNMPLLLGVHSAAILVVAAADKRVLATYRYSDIETLTIYPTESLLTLKMFKETPDGSNKCLTFETLQKEEIASLVAAYSPQHAAGFTFGMANAMVDVLSTPVANQRPRRLLKMTLEDRLRLHTEVINCRRALVTANIMRKPAAEHQTKWRTTLRRLGRSSKSNSKNNQINLDDDDYSHDEILRNYPRPFWAYIKEPLVSSLLVISDPDLEAAAVTMFEQILSYSGLRNDASQSDNSSTTTNGSSSSNEVEWCMRATQSEQNQIRQAQAILEKCLGGDADILRNEFFLQLIRQTTDHPIPNSRVNIKHWQLLALACSLTQPSDRRVLAYLHAHLRRCALDQITREGQYAQFALRNLQGTLETRGRRLAPSRPEIAATIQCRRVYARVHFLDGHFQAVEFDACAVIAEVLEQIQLKIELRTHAPGYALYQVLGQNGAEQALQPEDKVGDAIAFWERWHDEHLGQVQNGSTAAAGVVRNGGTQEPIHYFIFKKHLQIDNYVDFNDPVERELLYHQTLHNVRNDRFPLTDQEAILLVAIRAQLEFGDSHSNNMMVNNSLSTMIEANSGGLDDMSYNQLIGKTLPERLACRILVKDVRTQHQIQSGMDQQQAKAAFFNLIQSWPLHRATVFEVLQTYTSSWPKTLWLAIDQSGMHLLQPRTRNVLCSCEYRNLVDYTATSNSLMIVANVATAITKTIKYMFITHQALQISQLLRDYTSAVMNANSNRMAVNGGGGPLNRNGSLVMSSQTSSISNASNTTGSTGRRKSVEFDLALRNMSAADKNHPKSVAFSAALNPIPQPRRSLMAQQQQATYDTQMYIQQQQQQQLYQNQQQIQYQMLQQQQRKPRPLIRHANDSDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4K0</accession>
    <name>A0A922I4K0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4K0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="44" mass="5055" checksum="4BFF91D126CD4C05" modified="2023-02-22" version="1">MKEDDDDDEGDGEEIDGRRRKSMNGWSSSTQQSTMILFHKHIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I525</accession>
    <name>A0A922I525_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lysine-specific demethylase 3B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KDM3B</name>
        <name evidence="10" type="ORF">DERF_005134</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I525"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXXC-type" evidence="9">
        <location>
            <begin position="571"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9521480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="634" mass="73581" checksum="6CE4A188DF9425A6" modified="2023-02-22" version="1">MQPNRQQRIRKSPQSLCQQQQPNRNMIQDQQQQQQQHQSLSSQIDTRITRSKDRKNVEQQQQSSILMTMDNNCMKNKSNHRIMTNNNICATGGVYYNNKKSTTTTNSGRRQHQLDYSKIRRRSGKSNNNNQNRKVTSTMTTIRTNRHQLHRKNHHHHHRDRRNDSPESKDLSSPSSPSSSSSVVITSSSSSTLINESRTNLNNCEPCFKFFSRFVKEPKHFQCNDKGECLIVLANDDNNNGKNDDNSAQRFSNGTGGRCKACWLKLCIEKFKIDFDTRRSLMEKYCQKSTIESSEIIVDNKPVTTSKTSMLKKHKINVKNHNECQKPVLNKVQSTKKSETLNNVDSSMKKLKSMSNENDLQIEPQMLMKRKKIHKDSDENKQINSLKLQFSINKNEISSNNNVTMPLTMVDVQSSSEEIRFPYSINSSPNFIDHDSKYPIEQNTTIKTNVGTMKSAHFNHDESMMISTTEMFALNNDYQMTRRHEEHKQTKTNPLINMENLDEINNESTIHVEKSRWMKTKDKKKMKTAIDSMDRNSSEKFIISRGSYFQDNKTNHHNNQSTSSLLTNINNNNKKSRCKECEGCRAQDCGQCSYCLDKKKFGGSNVIKQACKYRICIRFRGSTRRQQQQKKQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I543</accession>
    <name>A0A922I543_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat domain phosphoinositide-interacting protein 4, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">WDR45</name>
        <name evidence="5" type="ORF">DERF_004508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I543"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9520821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="418" mass="46634" checksum="CB79F740CADC16FC" modified="2023-02-22" version="1">MNQHQREILNVSINDEGNLFVACMDSGVRIYNMEPLVGKLFIDSTIIGSVSICKLLHRTNLIAIVGGGQRPKFADNTVLIWDDYQKKFVLEFTFANRVLALKIRRDRLFVVERNRIHCFSFPNSPTKLFSIETRDNPMGICEVTPLTNAAEIQLLAYPGHRIGSVQLLDLSHTNRLLTVNNHHHQLYNAQQNLDTVEESDETMTNGNMTAATVAASASSSISPSSISAHTSDIASIALNRTGTLLATASRKGTLIRIFRTIDTDGNIANKSNINNHYQHNHHQQQQYVPLSPVQIIEFRRGIDQAMVYGIVFSPDSEYVLVSSDKGTVHIFALKDTRLNRRSTLSSMPLVNNMQLASYALAKFTLTAECACVCSFGGGNDRRSVYAICVDGTFHKYSFKHDGTCVRDNFDTFLNSINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I549</accession>
    <name>A0A922I549_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">3-hydroxyacyl-CoA dehydrogenase type-2</fullName>
            <ecNumber evidence="3">1.1.1.53</ecNumber>
            <ecNumber evidence="4">1.1.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">3-hydroxyacyl-CoA dehydrogenase type II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial ribonuclease P protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Type II HADH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DERF_005958</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:30800"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:30801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>11-dehydrocorticosterone + NAD(+) = pregn-4-ene-3,11,20,21-tetraone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42020"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78600"/>
            <dbReference type="ChEBI" id="CHEBI:78601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:24613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42024"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78602"/>
            <dbReference type="ChEBI" id="CHEBI:78603"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:42025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42004"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:36713"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.53"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:42006"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42008"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28952"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78594"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42009"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22433"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:22434"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42012"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17650"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:42013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42016"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16962"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78596"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ursodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42028"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78604"/>
            <dbReference type="ChEBI" id="CHEBI:78605"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:42029"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 20">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="3"/>
    <dbReference type="EC" id="1.1.1.62" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I549"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008209">
        <property type="term" value="P:androgen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05371">
        <property type="entry name" value="HSD10-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000215">
        <property type="entry name" value="3-hydroxyacyl-CoA dehydrogenase type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="21">
        <location>
            <begin position="10"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAH9522379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="256" mass="27149" checksum="93471E9A57EF2A07" modified="2023-02-22" version="1">MSGVQAIKGMVALVTGGASGLGRGVVDRLIRQGAKGVVALDRNHEESKYDNPNVLPITASVTEESEIQKALDACKEKFGRLDAVVNCAGVGIARRTYDFRKNQPHSLDEFQMVIEINMIGTFNVSRLAAGMIGANEPVNGLRGVIINTASVAAFDGQIGQIAYSASKGGIVAMTLPMARDFAPHGIRVMTIAPGLFDTPLLAALPEPARKALAATIPCPSRLGHVDEYAHLVQAIIENPMLNGEVIRLDGALRMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5J2</accession>
    <name>A0A922I5J2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5J2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="40" mass="4633" checksum="30A3B6582684BF4B" modified="2023-02-22" version="1">MPLCSNQNQQSNSSIIIPPMMVKSATPLNCIKYHRFRQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5P1</accession>
    <name>A0A922I5P1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glutamate receptor 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_005591</name>
        <name evidence="16" type="ORF">HUG17_3437</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5P1"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000078">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Solute-binding protein family 3/N-terminal" evidence="13">
        <location>
            <begin position="43"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="14">
        <location>
            <begin position="43"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="15">
        <location>
            <begin position="54"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7639404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9521987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="323" mass="37488" checksum="59FF2BF6D873FAA3" modified="2023-02-22" version="1">MIKSIQTFNWPFLLLIILAILLINPFYLTSSSSSSSSSLVSARILAGVTIESAPFINVENNKFTGFCVDLMNLIEEFTGLNYSLYLVADGTYGFGNEHTGKVSGLIGDVYLKKADFAIADMTVTEKRKQYVNFTEPFLRFSFSALARRSLVKNLQTMDDLAIKSDLAIGTFMNGKTMINMQLVRDKIRNVQWLYDQLLRNKTNLVTRLDEAMYKIYHERYAFIQEEPKNLYLASKDCSLKMLNDQNLYVPGEYAIAFRHDSPYIQKFNNAIKFIKYKGYLKRLIRKHFYNAQCMNSAYSQHWQQQYFYQLIISVSLTLYWTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5Z9</accession>
    <name>A0A922I5Z9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intraflagellar transport protein 88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">IFT88</name>
        <name evidence="3" type="ORF">DERF_005512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5Z9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44117:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 88 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="674"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="758"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="935"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="942"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="978"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9521893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1096" mass="122135" checksum="8158BCAEE1D8656C" modified="2023-02-22" version="1">MSSTRERIIMLNDDDDGDDDDDNHGGDDNEDLYKGYNEFHPALDTRNLQDDEEFRQTVNKSGYGRQLQSRSLQLRSGFRTAFSRSQNHSNSLIKSRGTAGGGGGGGLRTAIGTGGTGRPATAVRGAGYTSQSSQNRIFDPLGLANGSSAGQNSTIGNGSKSVFHLQDESTPEWKIKQLEKQIMLLLDESVQAAAQRRQDFGQALDLAKDCVAKERSLNRLKEQSGLMETYGPNSDLTLATMFNLAERYSDAQMWSEAINTYQALLKNRSFTNTGRFRMNIGEIYFRQRQYPKAIKFFRMALDQIPQIQNELRLKLMANIGLAFVRLTQYADAIAAFEFILAERGDWNDAETVFHLIVAYYALGDGDKMKYYFNKLLQVKVEDQFEERYGHHEILTNGGIIFAGGGGGGGGGQVGSTEITETIDNRTSASSSINQRPTSPILLIRDEQDHFNNLLIEAIRNDRLRQYEKESIRHVEWCILTAAKLISPFIQVDHGPTGPNGLMVMPIDSFNRIQLTNGELSTTTTTTTITSGYDWCLEQIRRMASITSTTSFGFNSGLNFVHLADELELYKATKQLRSREFDLAISTLKSFESKDRLLTASRTASANDPSNRLNMISTISSSATSSSSVARMSSATARVTATAATNLSFLYLLQRDYESAGRYADEAIAIDRYCLGAVLNKGNIFYRQGDFQRAIEHYQEVIANNSTILEAYFNLALAERKLGNYDRALDALYRLRTVIRIPKNRPNMLNQKITNTIEVDLMYQIGLIYESMGNQDQARDFFQKVLQLVPTDVGLLIKMADMASDENDRKQSLHYLLESYRYLPSHIPTIERLAAYYIEMKMYDQTIKFLEQLAIIQPSQIKWQLMIAASYRRSGNYPQALSTYQSIHQHFPENIDCLKFLIRLCSELESNEPNGSYGQLVEQYSDRLRRLEKTRELREEQKLTSSRSASRASTAAGRQTATAATYSNRNLSGGGGGSSSREGSAATTSSNGSGSSGYMTKSITPTKSSPRLLIATNNNNADVVNGGSSKSSTGSISAIVDQVVEQFDTTNMERPTTSWRDRNLKSSHGRAGMGRGVGDPDDEDFLLDANIDEMLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I662</accession>
    <name>A0A922I662_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I662"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037203923" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8872" checksum="EC1E2BDD10C23C74" modified="2023-02-22" version="1">MRCHSILLRSLIITLCLQQVLLRSFLLKNSKHFKCFSVQRFPIRSLSSNVLVNNDDFGGRGVVQRLKLNNPKKRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I666</accession>
    <name>A0A922I666_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Potassium voltage-gated channel sub KQT member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KCNQ4_1</name>
        <name evidence="15" type="ORF">DERF_000240</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I666"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013821">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF9">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03520">
        <property type="entry name" value="KCNQ_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01459">
        <property type="entry name" value="KCNQCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="13">
        <location>
            <begin position="151"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent KCNQ C-terminal" evidence="14">
        <location>
            <begin position="462"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9526132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="638" mass="73379" checksum="AE0615C4DC9B3631" modified="2023-02-22" version="1">MNIFNNNNNNNNNDNRDSSFSKSRFQVTPRIDIESAIEDLGEFRSPTPFAGNGGICDHDLSNEPLFELEENGNNNTVTTTSSSTNSFYNTIYKYRKLKQGGNSLDTVFFPPPPNRRLSTYPHSVVGVPFYNERILVYNFLQRPTGAWAIGYHVFVSLAVVYCLILTIISTSSTEYGNSLAKTLNTIDYMIVTFFIVEFLARIWSSECVSYYQGWKGKIRFFKNPIRIIDLCVIIVSLAVLISNIHGELLITSLRGVRFIQIFQMVRLDFKFRPWRMMASVVYSQRIHLAIVFYMGFLALILISFVIYFVEKDYNEDFDSLAASMWWAVITLCTIGYGDMYPKTSTGKLLACICSLIGVSIFALPAGILGTGLALKVQEQQRQLKISKRKQPAARLIQCAWKLYVAEQELIRTSDSSKYNIGNGNTASTLSCFRSVIWKRFETSKNKSKTLSWKEMNGLCFVFAVKFCISKRDFVKAFKPYDIKDVLEQYAAGHADMLAKIRIMDHRLEKIQSNSISAKAQHDIRLRFLTHISKLEYEMQKMQINLNDLMHYQVNSRLIIENLLKYLLDQQISLRCLSNNNNNNNRCRFGRLNQMAECNVCSNTNNRTTQLLSQFHKLNFVDKLEKIFQTFNQDVLLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7N9</accession>
    <name>A0A922I7N9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7N9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037047314" evidence="1">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="132" mass="14938" checksum="DDA2956179F22601" modified="2023-02-22" version="1">MYFVSKSVIFFAAIILIANYPSTVISGPTTEHPIVENEDDFGFDDVLNIFKNTGKLNAQIAKIIAETIRLLEIDDDHVLVRCAALKAKLMATEAAMNIIRCHKAERKDSFECKHLQRLVDNLKRELKYANCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8C9</accession>
    <name>A0A922I8C9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8C9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06543">
        <property type="entry name" value="GH18_PF-ChiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052750">
        <property type="entry name" value="GH18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42976">
        <property type="entry name" value="BIFUNCTIONAL CHITINASE/LYSOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42976:SF1">
        <property type="entry name" value="GH18 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037632592" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="346"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="403" mass="44751" checksum="BD2854DD20CCBCC9" modified="2023-02-22" version="1">MKIEIFCLFLITSSLWMMSIEAAREPAVSPYVDATRMPNENYLVDLHRETGLNSVTLAFVLGTGYGCTPSWGGESTLQDSRIINAVKAFKNVGGDVIVATGGAMGPYLEATCSSPDQLADAYKKALDIVDSTHLDIDIEASINVDIMMNALKKLRSMIPSLTISFTMMVQGDDYGIVDILGVDILKRAVQNNVEVNIVNGMTMEFGSKRASWGDAVIAASESLHRQMKQVWPHKSDEELYTMIGVTPMIGRNFNGKIFQIKHAEQLVDWAKQRKIGHLSFWSVGRDNGDCPGGGVSPSCSSIAQNKFEFSKIFQQYSGTHIPDHFSTTKKPSTENPHHSTKPKPLKIDCSTGVQYIPHETYCDKYYWCFEGKPHLEQCANHLVWDPKINSCNYAESAQRTDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8G5</accession>
    <name>A0A922I8G5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">WD repeat-containing protein 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">WDR35</name>
        <name evidence="14" type="ORF">DERF_000949</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8G5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056158">
        <property type="entry name" value="Beta-prop_IFT121_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056159">
        <property type="entry name" value="Beta-prop_IFT121_TULP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057979">
        <property type="entry name" value="TPR_IFT121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057361">
        <property type="entry name" value="TPR_WDR35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017233">
        <property type="entry name" value="WDR35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056170">
        <property type="entry name" value="Znf_IFT121-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF5">
        <property type="entry name" value="LD29485P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23390">
        <property type="entry name" value="Beta-prop_WDR35_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24797">
        <property type="entry name" value="Beta-prop_WDR35_TULP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25768">
        <property type="entry name" value="TPR_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25170">
        <property type="entry name" value="TPR_WDR35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23145">
        <property type="entry name" value="Zf_2nd_IFT121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037536">
        <property type="entry name" value="WD_repeat_p35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT121/TULP4 N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121 second beta-propeller" evidence="11">
        <location>
            <begin position="330"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like TPR repeats" evidence="13">
        <location>
            <begin position="1053"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="IFT121-like zinc finger" evidence="10">
        <location>
            <begin position="1213"/>
            <end position="1254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9526891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1255" mass="145030" checksum="05D31CAA92FD11E3" modified="2023-02-22" version="1">MFLHLNKKISIPNCSQVRCIAWSWEHEFIACGGEAGMLKVIKLESNVNQHQTSKNDLSKNLSVNQTLESHKATVESVCWNEKFQKLTSSDANGTIIVWMFYKGMWYEEMVNNRQKSLVTGMAWTHDGNKICIVYEDGAIITGSVDGSRLWGKELKNISLNQVEWSPDGKIILIGTKDVEIHVFDHVGNFLKKMSLNHTVVAKAAEKLIAIKWFKNGTTSNHYPRRLIIAFDNGVIQLMRNESDYNAKLIYCEMGITSIEWNYNGDMFAVTGSTGNKNFIKIYNDQAQLLTVTKIPGNEVYDCSWEKNSRKLVLAVDSFMYFANLKCRISWCFLSNSIAFLRNNFDDEQKKKRSLMFWELKTNKRNERSADNFIQMACWHHYCVVVDKMDKLQSNNNKNNTLENNQSSSNKDVYCLNLYNSIGTLIDYHLTDLQQIKFCCMNSNRVIVASDNSFYVWPFKQLYNANSFKSLAFYSDNLYQELTQNIANDNDLMAGGSVGVKSRRQQQSSSTSFVVVVTDNDNISCVTVSEKFFIVGFESGIINQYLLPNASFINKIQLDASPSRMALNKNSTKLALTDRNSRFYLYDFEANNEQTWTEGNWIEISNTVAKLTDIWDFKWETDNNDLIVLLEKNKFIVINLYKGGVKILDPILFDGYLCSFQQLSIQTIALDQLIVDISNHLDNLDVNDYIVNIPSHYVNEIKNLINEKDSITDAINYAVKIPELPSLWTIVSNECLKNLDIETAYLAMIKNRDYKGLQFLKRLNRIKDLNLKNAEVCAYQNHIQQAESLYLQELDRPDLAVYLNKMNGNFERVRTLLEKYNNLANHDKEMKECYMNLGEYYQDNYQWQQAIRYYEKINAYDQLAECYISEQKYDALVTLVDKVNDEKILLQMAMFLESLGFCKDSVRAYIRANNFEMATNACVKLSEWKMATELANRYKTKNVDMLLEQYIQHLETDHKYMEMIQVYRNANMIDKAVAIIIKLIDETKKMDNNDGASLLKKLHLLIGIIYEENKLNNQNSGRNNKHETLDELLSQNDIFANGTDQQHQPIISTDPWKGAEAYHFYLLTQRNLYRGKYQLAMNCALHLQDYEEYLTVQQIYSLLALAAYANKCYDICSKAFIKLESIDNEQQCKWNSCINDLFNVNTTSTITTMANEEKKRIEYERMAVQIFLKNSPDENSSSNNVSTNISCKFCGQSIPEYSATCPKCQTKFHACVATGKSIIDQRKNWTCKRCRHHAIQEEIVSYTNCPLCHVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I963</accession>
    <name>A0A922I963_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epidermal growth factor receptor kinase substrate 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EPS8_1</name>
        <name evidence="5" type="ORF">DERF_005322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I963"/>
    <dbReference type="OrthoDB" id="4680325at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11764">
        <property type="entry name" value="SH3_Eps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039801">
        <property type="entry name" value="EPS8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055093">
        <property type="entry name" value="EPS8_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035462">
        <property type="entry name" value="Eps8_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287:SF23">
        <property type="entry name" value="AROUSER, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12287">
        <property type="entry name" value="EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22975">
        <property type="entry name" value="EPS8_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="336"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9521688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="686" mass="79116" checksum="BA71CD49BA5FD3FB" modified="2023-02-22" version="1">MSSPQSHRHHHRHHHHPHHHHRTNKINENYSNERYVSILNHCFDDIETFISRLQQRKLQKRNHHKRGGSSDGFLTKYAPGSCDEEFFEILSKFKLAFNLLAKLNGCIHDPNAPELVHFLFTPLAIIIQAAHENEPPMDPSLVEIPYLSPDAIEFLLNCCTSIECDLWRSLGDNWRKSVKHIRMTSPFQPIFNDGWTPAITEPELLGIIIPTLMATEIDMDQEEIITARSSSIPNKSRSPTSFDDDSDYEDQHTNGDNNPRIIAHYHHHHHQQQQHGNRPLSSPIGSIEQDDQLPSSPSLSLTMVDHNNINNNGNSNDQQTINVVQMEWLAELQSRNATKIVRVQFPRTANNNKELTVTRGEILEILDDSRKWWKARNSLGQIAYVPNTIVVEIESPMMKTMTAANKLNNTTHREDGNYHVYSEIIRRHSSSLSPTNRQRLHIEKKNSFKNNKPMEIKMKIVPSPPPPPPPLTPSPSTPPSFTIIQSPKIEINKQQQQQQQSESFVDDKISTSSSLCSTSLISLSQFSINTYDTIEQELNDRFKNPMIMGQTDKTKNHDEFMSRYNGKNENNFTGEDLSMFLTFKEFPPELINFVENLFQIKEIRCNLFHWNKNELRANIPMNIANDFLIQRLWSNLLLLKNMVKPSKMDTLAIILKQRKRLLIEKMKKDSDTAAEKSNSDTLNDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA36</accession>
    <name>A0A922IA36_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase HAL4/sat4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SAT4</name>
        <name evidence="3" type="ORF">DERF_006310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA36"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
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            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
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            <end position="539"/>
        </location>
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            <end position="597"/>
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    </feature>
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        <location>
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            <end position="648"/>
        </location>
    </feature>
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        <location>
            <begin position="657"/>
            <end position="692"/>
        </location>
    </feature>
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        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
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        <location>
            <begin position="703"/>
            <end position="740"/>
        </location>
    </feature>
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        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="753"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9522749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="828" mass="86602" checksum="4A83FE4354F744E8" modified="2023-02-22" version="1">MPYFDHQMATSISDSPSDSQSSKSMGSKKDKILRTVACSNKKTEKITHKDPDASITSKYKQNIDLRKLMFMRNLLKAEIETLQKTKGALPSDNNPNYAKYSYDTNKSLQQQCASDSQFYEAQNTDYPAQPLCCQLYDSKSSGIESNSLYLRTIRHLGKKHQSIVQTWDLFINSSGNIEIFQEYCSAGNLEQFVENNTLNEKQISLYAWQLLRGLDFLGDIGISHRDIQPHNIMLRPAQKDNFLKITNFHKSIIYWNVTENDVIYVQCEPKDKQGDKNYQAPEIYGDPSKEEFDPIIADTWSYGAVIHFMGSKQYPYNVGSKSDDLDKEIADNVDKLKSLSKDGKDLLKAILKANASERMPIGLIEKSSWFNDAKRAKLKILVDKNAPVAKGGAGKVADFGKSNIFARPSEFKSTASTKKEKSSSSKKSISKSKSLSSKSKSKSKTMADNDDGEASDQEASASGAASSSSKSGKTSGKEDDEDGESGSEGDGSSGKDDEASGSQSKSGTTSKSKSKADSSSKSKSKSSASSKSGATSGEESGSEEGGGSENDGSGKDEQSGSSSAKSSAKSTSKSDTSSKSKSKSSSSSKSGATSGEESGSEGGSENDGSGKDEQSGSSAKSTSKSGASSKSKSKSSSSSKSGATSGEESGSEEGGSDSESGQSGSSAKSTSKSGASSKSKSKSSSKSGATSGEESDSEEGGSDSESGQSGSSSKSSAKSTSKSGASSKSKSKSSSKSGATSDEESGSEEGGSDSESGQSGSSAKSSAKSTSKSGASSKSKSKSSKSGATSGEESGAEGSENDGSDKEEQSGSSTAKFYVNVGSIVEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAF4</accession>
    <name>A0A922IAF4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AT-rich interactive domain-containing protein 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ARID1B</name>
        <name evidence="4" type="ORF">DERF_001228</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAF4"/>
    <dbReference type="OrthoDB" id="8709537at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035060">
        <property type="term" value="C:brahma complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021906">
        <property type="entry name" value="BAF250/Osa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033388">
        <property type="entry name" value="BAF250_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656">
        <property type="entry name" value="BRG-1 ASSOCIATED FACTOR 250 BAF250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12656:SF5">
        <property type="entry name" value="TRITHORAX GROUP PROTEIN OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12031">
        <property type="entry name" value="BAF250_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF-like complex subunit BAF250 C-terminal" evidence="3">
        <location>
            <begin position="324"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9527192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="652" mass="75057" checksum="45F898A0FF446D77" modified="2023-02-22" version="1">MENQGPRSTSVMEQPIRMWPMINNNAGNNQNRIISNNNIVKRENVPKPGNNIYLRQALGFTSLKASPNQIMDENIVERTKPMFRKIRKVTKIGSIDMKKLIMSLESGLLAETTWALDCLHIMSSNGQLQLQSNLSGRLVEYYKCFLDAIFDDLFVDTKIDYQLKMMSNDSDGPNIVSKTNSNNLIEPNDRIYLLDSTNYTFQSRNGLPVKLKEDVDLNANIVNQLEKDWLDIFCDHQYLQNGNTMSTAHIIRSMNPMQEMVPFIRPITDKQQQQQQQQQQQHVNETQQNKRFMVKKRKLELDDEAEKFEISSTLCPRLEAYESMLKRCLCISSIIRNASFSITNSRMMANDVSLLLVMARLLSYNHEHDEKKTFAMILNSVTNRNHNNNNNNDKENEIFLGELFDDFSFETLHMIRMNTLVTLSNLSEHLDLCQYSDKIILPLLDGLLHWIVCSSSYARDPLPPDNLSCQIQALEIVAKLSIHQSNIDLILATPPFNRIEQMYRVLVETIGRNDDDQVLQELSLVVLAHFSHGDLLSARIILHIDLVINNLLAFIEQNEFHNRMNGICLTTTNSSLQHPDECSINYIIGLAARTLRTLASACDHNDCYLFYKYENRFVDLIMSIFLDTNVGQILADLMFILSNRKSVFNHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAP3</accession>
    <name>A0A922IAP3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001545</name>
        <name evidence="1" type="ORF">DERF_005993</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAP3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7398" checksum="DF16DCC5A9CEB08B" modified="2023-02-22" version="1">MNFGYPTSWNTDFKARAAAIGVKSSRIPIRRQRVDKHATIKPQYFLLFRNVNGPKPSIAIRLKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAT5</accession>
    <name>A0A922IAT5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_006049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAT5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9522483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="119" mass="14045" checksum="53F26F3D580E0B66" modified="2023-02-22" version="1">MTKLINMVVTINMMMIIVMITISEAMKQQKLMPPPRADNAYGRSACYLCPKTKRSIQQMTKDISEIKHLVSKCKCGDKQPPSNDENRIEYDYDDYNYDEFSSRHQHRHQRQEDDNEEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAU8</accession>
    <name>A0A922IAU8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Thioredoxin- transmembrane protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TMX1_1</name>
        <name evidence="5" type="ORF">DERF_001430</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAU8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040397">
        <property type="entry name" value="SWAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019147">
        <property type="entry name" value="SWAP_N_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161:SF4">
        <property type="entry name" value="CLK4-ASSOCIATING SERINE_ARGININE RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13161">
        <property type="entry name" value="SPLICING FACTOR SUPPRESSOR OF WHITE APRICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09750">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01141">
        <property type="entry name" value="DRY_EERY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Suppressor of white apricot N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="657"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="699"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="737"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9527413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9527414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="773" mass="90839" checksum="3982AEF7D6871D44" modified="2023-02-22" version="1">MWHEARKHEKKIRGIMIDHRRRAEKRREFYESIRRDPASYLQIHGQQMKIHIDPLISQAAESSLVPWMGDQNNMIDRFDVRANLDCIPSSADVGTNDNDEGLLTSDQECQLNYERFRNLVQNDFVDNNEQKVLHKIFLKEKWGEQQQQTNNVKTKNELKKKLAEKKSAIGYNYDDNDGKSSKNDDETSSESGDDSDDEEFEDLDTIVFVDQLDLDMCERVNIVAKKYGIKSGAFMKFMQADKAEADRLRIAKEIENEKSMFVGRKSRRERKVLIQQQSNKKKLSEKSKQIPAKQISSNQPLIYGPTLPVDVANSKVDSNIRFNHTSNSNVKNRRCFREANNDEKFTFDRSPSYTIRRSPSVRRRYSSDDANSSDESMSHRSRSSRRRLSPPSRYRSRSRSHSRSHNYRRSRSKSPRRRKTSYRKRSRSKSPIRRSDRPSSRHRDHKQKQKSPNQSLIPIKTNDVKLETNDDNMKLYKLLEKIESNAKKCRRASSRDRKSEKTDEIEAKSQSESKSMINLVVEKEKSPPIKRYYRHDLVDSQSGDDHSDDPNIDSDEKKSNLSVIHANSSEPTKHSSLTNLTPSAASKSNSSSSSSLVITPQERLKRLMKAQLDKQCLYYYMKYEFLNFNIIINFKLDKLDKKAENDRLERRKIEQRERKEEFDKLSRRNRRSPSRSSDSSRSSRSSFSSYSNSDSSYDRRKRYHSRSRSRSRSKSRHGTKERYRRQRSRSRSITPHDRRHYHHHHHHHHSNHSSTSSKHHHIALLNHCISLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBC9</accession>
    <name>A0A922IBC9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_006314</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBC9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="34"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="205"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9522753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="378" mass="40619" checksum="6076AC485863B925" modified="2023-02-22" version="1">MSTVGKDIECYAAVAWEAKKPLSIEKVTVSPPKAGEVRIRIQYTGVCHTDQYTLSGIDPEGLFPCILGHEGAGIVESVGDGVTSVQPGDTVIPCYIPQCNDCKFCRSSKTNLCSKIRNTQGKGVMPDGTSRFTCKGKTLFHFMGVSAFSQYTVVAEISLAKINPKAPLKSVCLLGCGISTGYGAVLNTANVEKDSTVAVFGLGTVGLAAIFGAKKRGAKEIIGIDINTKKESLAKKFGSTRFVNPKDYPDRPIQDVLIEMTDGGLDYTFECVGNVQLMRSALEACHKGWGTSVIIGVAGSGQEISTRPFQLVTGRVWKGSAFGGWKSRESVPKLVEEYMASELMVDEHITHRVGIDDINKAFDYLHSGDALRVVVDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBI6</accession>
    <name>A0A922IBI6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBI6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="390" mass="46412" checksum="8ECC99B97DE9D540" modified="2023-02-22" version="1">MDNKQENNEQMNVYGMYIQKYFCDLQHLQLQHGRLWQSYRELQIKSSKQTGGHHSNNPHHHHNDTKTDDELRQELEQEKMINKSLNTEMAQIVDNMKTLETRHKEFLAIFNKDNKQDSRIKELENENKELRETLDFVTSENTVFKDLEERAFNEKREWIEEKKKFEEVVVWSKHLNDKYKTTLAQNEKYGQQMDKFLNCIHDTFIQCSNDNDLSLLIEDFRKCSINNESFDKKLEIAEKFLKSLPKQHSDIVNNNDNNNNNKLDSKLKISDQQKENIQCLKTEIAELKNLLINNGMSLEQINLKLENTELSEKLRLKEETLEKLKEKFARNRAVLEENHRRSLDEIKTLDNFIAIIINKLNKLPEDLKKHNELKELITIVNENDSDPDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC64</accession>
    <name>A0A922IC64_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC64"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7879" checksum="2B552EA2CCBA7C06" modified="2023-02-22" version="1">MIKLHDADDDDDDEKWNSSATKEMLMKRLFSSRTKKKTEYITVIMIIIVSRIRKQSYKKKLFIVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC70</accession>
    <name>A0A922IC70_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dual specificity protein kinase clk2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CLK2</name>
        <name evidence="12" type="ORF">DERF_002318</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC70"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036966735" evidence="10">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="114"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9528365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="444" mass="52421" checksum="59FD793E24BB5F96" modified="2023-02-22" version="1">MVILCFPGSCCLILPVDLFTYLNNNNDDNDDVDQKQSERTSDEDRSSKQQTHHQSQQQQKSDHHRKGGHNNHNNNNSSNHHYHQKNQTESTTTIEDDQHGHLIYKNGDILQDKYEILATLGEGTFGKVIRVRNLKTNNALALKIIKNVDKYREAAMFEIKVLQTIAERDPKGRNLCVRMFDWFDYHGHICIAFEMLGLSVFDFMKDNNFQPYPIDQIRHIGYQLIFSVKFLHENELTHTDLKPENILFLNSEYDVELTKKRKEIRRVKNTDIRLIDFGSATFDYEHHSKIVSTRHYRAPEVILELGWSHPCDAWSVGCILFELYQGMTLFQTHDNLEHLAMMERILGPLPYRMSRKSKTRYYYHGKLMDWDERSAAGRYVRENCKPLHRYIIQPDNDDHRNLFDLISQLLEYEPNNRLSLQDALDHPFFKRLPSEQRLHDDDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICW3</accession>
    <name>A0A922ICW3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Paramyosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">unc-15_1</name>
        <name evidence="13" type="ORF">DERF_002357</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Paramyosin is a major structural component of many thick filaments isolated from invertebrate muscles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paramyosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICW3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030239">
        <property type="term" value="P:myofibril assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000035">
        <property type="entry name" value="Paramyosin, long form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349">
        <property type="entry name" value="CINGULIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46349:SF6">
        <property type="entry name" value="MYOSIN-6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="7" id="KW-0518">Myosin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0787">Thick filament</keyword>
    <feature type="domain" description="Myosin tail" evidence="12">
        <location>
            <begin position="34"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="117"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="647"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9528407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="870" mass="101785" checksum="E0516EB05E120DB5" modified="2023-02-22" version="1">MSARTAKYMYRSSGAGASGDISVEYGTDLGALTRLEDKIRLLSDDLESEREMRQRIEREKAELQIQVMSLGERLEEAEGSSESVTEMNKKRDSELAKLRKLLEDVHIESEETAHHLRQKHQAAIQEMQDQLDQLQKAKNKSDKEKQKFQAEVFELLAQLETANKEKLTALKNVEKLEYTVHELNIKIEEINRTVIELTSHKQRLSQENTELIKEVHEVKLQLDNANHLKTQIAQQLEDTRHRLEEEERKRASLENHAHTLEVELESLKVQLDEESEARLELERQLTKANGDAASWKSKYEAELQAHADEVEELRRKMAQKISEYEEQLEALLNKCSSLEKQKSRLQSEVEVLIMDLEKATAHAQQLEKRVAQLEKINLDLKNKLEEVTMLMEQAQKELRVKIAELQKLQHEYEKLRDQRDQLARENKKLTDDLAEAKSQLNDAHRRIHEQEIEIKRLENERDELSAAYKEAETLRKQEEAKNQRLIAELAQVRHDYEKRLAQKDEEIEALRKQYQIEIEQLNMRLAEAEAKLKTEIARLKKKYQAQITELELSLDAANKANIDLQKTIKKQALQITELQAHYDEVHRQLQQAVDQLGVTQRRCQALQAELEEMRIALEQANPEQLHEEAVVRVNELTTINVNLASAKSKLESEFSALQADYDEVHKELRISDERVQKLTIELKSTKDLLIEEQERLVKLETVKKSLEQEVRTLHVRIEEVEANALAGGKRVIAKLESRIRDVEIEVEEERRRHAETDKMLRKKDHRVKELLLQNEEDHKQIQLLQEMTDKLNEKVKVYKRQMQEQEGMSQQNLTRVRRFQRELEAAEDRADQAESNLSFIRAKHRSWVTTSQVPGGTRQVFTTQEETTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICX1</accession>
    <name>A0A922ICX1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_003110</name>
        <name evidence="2" type="ORF">HUG17_5123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICX1"/>
    <dbReference type="OrthoDB" id="6512993at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276979" evidence="1">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7642078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9529216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="152" mass="15583" checksum="C998DA52710C62C4" modified="2023-02-22" version="1">MKFFIVALSLISVAAAIPAIGHLGYAAAPLALGHTASMAIAGPAIAAYPAAYPAAYGYATHGPAPAGLGGHGFGHGGHFSPMPMQEVRLVGVPQPYPVAQPIPVDKPYAVPVDKPYTVPVDRPVPAPYVAKVVQPMIHKQTVVSSAILPAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDB5</accession>
    <name>A0A922IDB5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDB5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9197" checksum="47D7BC6725FAFCE1" modified="2023-02-22" version="1">MKSYSLLLLFVRFESHRILRSSKGILFVSICVILMFMCNSGSSRSSTGRTCGCLCQNDDDAEMIGPWLLFSTKFSMADLLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDP2</accession>
    <name>A0A922IDP2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CCR4-NOT transcription complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CNOT1_1</name>
        <name evidence="5" type="ORF">DERF_002105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDP2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1103"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="704"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="783"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="858"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="704"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="785"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9528135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1253" mass="137661" checksum="772E9CC7EE76BFF7" modified="2023-02-22" version="1">MPSDVHIEQQQSLSQFRHLSSPPSPSSSSSSSTTTTTSVKERRSMSEQTDINISGCTMIDGQPESIYMQRYKALRDAGFDETTANKYSPLYSSVNEVIDAILSQSLNDNLTTNGGRTIMAKKGIDNNSYSTAIYCNGNNKSSTIMNYNDTSAINAAELLSELTDSISMNKTNNNNNNNLIMECIHGQSPSSTSSKSFLYMSNGDSNGSVINSNDLISCSSNESFHNHSHINADGNYLSLSNCIGNSHRNSLMKNTIFSSESSESSTDNNRSNSSNLIVTMLKDGLLEDSSDEITLEDDVGLLADGQNGNGSSSSPSTSSSLSSGISSSFFMDTSSSSPSSFSSLSSSISISPPSNQSIVANFEQQQQRQSTNNNNGNHHQTLTNDNGTLISLFLSKQQQQKSSNNNNNVQNNGKIKSTSAKTITTMMMNDSNDIIISNGYNNNNNNRMHNGINKNNNNNETNDLNCETFSFSLDNLSTSSSSSTSSSLSSNTTTMESNQQKNGEQTFDGLLENHHHSMIIGNNKLSFNSNNRLSMKLYGNGNDSAENSHHHHHHHYQQNNNNKLLHPVNGNNSDSVPVVEPNSFNDTGHISGVDGGHHYRHNLHFPSTTMIDKFNVDSGCTDLLFDNHDQQNPKTTNGLMMKSCQPITVAAGYRNSDDTLNDLLGYLNLQQQLFTNNQPQQQQQQQHLQYGNNFDHRNCSMLATVTTPTSSSPSSSSLSSNSLSTTNNNNNDVISSSSQSSSFDENGVNLKNTVSDIFNNVENNTATTIVGVLNEINNHYHHHQNNNCNNKNNYNNNNNSNNLNLFSSSTPSSSPPVSINTTSTSLLIDTLNTMNDSIFNQACSSESVTNLEQHHQLNQNCSPNNYHQHHHHHHQHHSQQQYHTFLTTAPNHHANHQQQQQQPRTFADIAASSLNGHHSNGVHNNNGNNVLNSSGSGSNNIDLVDSSSFLSILDSPTHKSLNCSNNGNNGTSNGYFNAFTSSSNIPVANTIQSFYDQFNTEQNGLNKKFYRKQQQTQALNFRPIGASPLSPSMNVNDANKLLKSGQIKESQLGFIRSSNGSLTITDCGGHIGIGDNGFESNGITMNENNTQSPNRPTNLMGYKGLWVCNVSPEVGLHYLKRRFRRYGHFTGIQTFERRATNGTNIVFVHYDNPNSPVEAIAALHNYNGQDLCADPNEPLKLRFAPSMEQSRAGQLPTLEQARKIVEKSGECFNWRLSSGCHRGQRCHLKHVSINKEIDSQPWVKALKKKINET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEH7</accession>
    <name>A0A922IEH7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FLYWCH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_003597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEH7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9529730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="195" mass="21926" checksum="1818AFAAB1EC6FB3" modified="2023-02-22" version="1">MISLNGYLYKQEKSKNGFTYCCCAYKKHHNCPGRLILREDGGYEEKSYHNHPVDIDLIGARRLINNMKSAAKARPDGPTKIIAEELANFFANHLPAYTNFIRTVQRASKPLKRSNLESIRFPDKCAQRLRLNISQYGACSNKYITPAGNKVVYRRFGTFKLGYVLCSSTATSDMTSSLADAISPQMGCVKLQSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFX1</accession>
    <name>A0A922IFX1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFX1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6927" checksum="2E15FDCCD16A2AF0" modified="2023-02-22" version="1">MIIIIVMTVINQKKNITRYINVLRISVAQPLDIFLDSGVRLVLSLYCQYYRLNLLIIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG10</accession>
    <name>A0A922IG10_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Gamma-aminobutyric acid receptor subunit beta-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_004085</name>
        <name evidence="14" type="ORF">HUG17_9409</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7638303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG10"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000045">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="12">
        <location>
            <begin position="9"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="13">
        <location>
            <begin position="216"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7638303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9530267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="44481" checksum="E5C11D5032242731" modified="2023-02-22" version="1">MVRQMVNKRHYNKDIRPDYGSGGPLIVNVTIAIHDIYDISDVNMDFTIDLHFRQYWRDSRLMFEPISNITRLFMGGDFYELIWLPDTFFLNGKSLQTHQSTASTRSNTLIELSHNGSILYSTRMTVVASCPMDLSYFPADRQRCQLNFGSYGYTIDDIIYKWTPGKILLEDRNLATFTVSGLNNSHQIRHNDVGSFSHLILYIDIERSTGYYLYQTFIPAFLIVLISWIPFWLGHDDHVERVAIGVTTVLTITTLITSTMESLPKISYVKALDIYLFVCFIMVFISLIEYAIVGYYEHSRRIRFIHQCLCLKPIATGQQPTNEPNHHQQHNNILESRLFMDQTSSIDYYSRWLFPIIFALFNAIYIWFIFSVKEFYHHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG42</accession>
    <name>A0A922IG42_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG42"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="194" mass="23048" checksum="35275B2E4A25A105" modified="2023-02-22" version="1">MFIGMTLAMPNPIAKDTYNNKVSELLIDRARTLVEKAKHVIDENKEQHEDLLSSIKNLVEQIETLSDKFEKEYHGLDLTKNEIHTMSEELLHFENRLTEEFLIFYEHIKHNDDDDEDVDHLIKRGEELIKKAHDVLRQYHPDYKTTAVVDFEIAAVLKLIKIVRHGDEETRRKYIPELKHQLRSLEIILERIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG65</accession>
    <name>A0A922IG65_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Amiloride-sensitive sodium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SCNN1G</name>
        <name evidence="14" type="ORF">DERF_004033</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG65"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9530211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="521" mass="60590" checksum="970B7D66711F09FF" modified="2023-02-22" version="1">MIFIRRDKCNAFTGFAIKRINGETLIWAVILTITSVVCLLFMAIIAKQYYKYETTISIYNEQPDVLNELPAITICAANVFTPRQLAGICSHYFLSLTKLMLDSWPKNETIICPNQQEIIENQKAFDRFESKAFEDYTAYEVIVEKSVQIEEIVAGCKVYPVSIRNMFDSVTLVEDPLSIDGIECSNLQEYMPSVYEGQKCFTYFSSMHDMKEKWLQYIPPIADVERLVFEQCVNDSLSCHWPTRQSNRTWNHCLRDNFAIFYDLQTMIKIDIRMDIDTLHFLSEKAIKLTVHSSDTLINKRKYKYLHVTGPYLYEVVFTRRMSMLMDRPYRPFCSHYGKHSEDPKLQVFHTNEECRNYCIKNHISQMAHSCQSYYNVLSASAVFEESLRREHICPHDQQNISLYLVAKQSCEAVCPEECHQSIYEISGYRSFSRGLFDCTDEMIYEQQQITNCFAQVYIRPSTEPFQLIQHRPAISYEEVIGAIGGNIGMWLGMSIFSIISLSVSCLQRCLVKMVYGQHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGM9</accession>
    <name>A0A922IGM9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RCC1 and BTB domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RCBTB2_3</name>
        <name evidence="5" type="ORF">DERF_004152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGM9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="147"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="197"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="251"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="372"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9530340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="496" mass="57007" checksum="6C3D480DAA72AA5C" modified="2023-02-22" version="1">MARSLIESIDFKLFQDDFKNIDQKFLQSVVSIFSFFTFKEIYFEKQFLLITENATYAYGDEICSWFSLEHDMTKPQRISLFNDVIIVQVDSGHGFVAILTDDGRVYLASNDSNWKTNNTFRLINTGNDRFKMIACGWHHLLMLRHDGHVFAIGHNSFGQITGNEKSSYESMIQIDNLKNVKLIACGGYHSFSITKNGEIFSWGLNDFGQLGLGDEENRITPCLVAFPNANSTRIKDIVAGEDYSLFLFKNGEVWGCGSNYAGELGLGDENNRSILTKIPIENVQQIACSSFHSFSLAHDGSSYYAWGETKNGTNWSSPRKLDDSHSSFASASVQVLDSPLTFGLTSTIYEFGSHDSISYKSILPLFDNQDNYDVKFIIDENYIKACKFYLKSVSEYYRRMFSGNWIENDQVTIDDYSYETYYAYLRMLHTGKIHINRQNITELVDLANCYGDERLMEYCETFIRNDLDEQTMPKYLPLINKYELKGSYTIPYYMPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KUK2</accession>
    <name>A0A922KUK2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDAN1-interacting nuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_013096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KUK2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029404">
        <property type="entry name" value="CDIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31661:SF1">
        <property type="entry name" value="CDAN1-INTERACTING NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31661">
        <property type="entry name" value="SIMILAR TO CDNA SEQUENCE BC052040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14811">
        <property type="entry name" value="TPD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9497086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="259" mass="30668" checksum="1EE0FD421933C320" modified="2023-02-22" version="1">MALVSYEFRREYPNKYSNTKANMQQILHEWNDTATTRTLSILELAQKYNVCAYSLMRYIVNQTSPNKDTAKLWLKNPNHCANGRLAYEIMEINLYDLMDGVFSQKISLNVGMAFEMEIRDYLQQNQVSFLCEQQLRDRNYDVTPDFRLNLPLVLIRQSNSNNKDDDNNVRLFRINKMDQIKQELIDNNNERIMLITWIECKAMFASIDCHIDYYERQYLSYINRFGNGIVLYKHGFIDDAIPAEFTRNLIIMQQMPAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KWQ4</accession>
    <name>A0A922KWQ4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KWQ4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="120" mass="14302" checksum="D7527382D4FAD39E" modified="2023-02-22" version="1">MRNRMQKFFNQHQHQQRKDNFEEKFYEFDFVEIFTVNMSSTSSESNTPRITKNGKINFEHERLKRLQNQSLKIFPPIKISMANEEQNDCEKCRQNDTGSAEADCCMLDVPIEQFIDIQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KX91</accession>
    <name>A0A922KX91_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KX91"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="108" mass="11052" checksum="01A8345DF55D319C" modified="2023-02-22" version="1">MKSESSAAVSAAAAAGAAATAPPPPDGTDANFSVPISPKNERQNVNFKIIAKIVINKPCAINSSIDLPFNSVTTLDNFSLSTSTPTLLNILVISSDDGSLLPPKTANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYH1</accession>
    <name>A0A922KYH1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_016065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYH1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF26">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="471" mass="54725" checksum="C93928391DE8548B" modified="2023-02-22" version="1">MERHDDNDDYSDIDHHHDEQNYGQQQQQHQQQHQLPPSSNSFNNLKNDHHLSNNFKNHHYHHHHNNNKIVKHIPSVLYPSDLWLKQQVLLDIEKIFTATPSPSPPPPVPTPPVPPTPLSPVVANPESKRPPDILFKKRSKTKVLTKIKSKTTTTTLFPAKDFDEPLLSAIKSMEKTDAIVKTRRKRTINLPRTRDRRFRYQKPLPTTTTTMEQSPKSPSPPQTTNKCLNNNNNNNKDNKDWSTSMKQKKLIKTTGSSGKKIESLKTPSMILMAAAAAAAAAADEKKKFIINNKNDNDDDNDNSHRCYSTMMINDPKEQTSTIIENIKNLKIDGRNYHHHQHHRVQRKKLIEDNYNYHHDETGTIRTNTTKIDNEENRNNNNNNNNKNIRKAWKQQQQDQSPSILIWKKNLRPMSRIYDSIKQQQQQQQRPHSMMILKRATTTPRRRATTTTTTTYPRSLIKAIENFLKNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYU0</accession>
    <name>A0A922KYU0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ARIH2</name>
        <name evidence="12" type="ORF">DERF_013612</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYU0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20360">
        <property type="entry name" value="Rcat_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16773">
        <property type="entry name" value="RING-HC_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047556">
        <property type="entry name" value="Rcat_RBR_TRIAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26000">
        <property type="entry name" value="UBA_ARIH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="148"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9497638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="506" mass="59993" checksum="A4A47F93892FBE23" modified="2023-02-22" version="1">MMHNDDNDDEYHYDDTDDWNYDNYEDFGEQIDDNDDRPTKDLEHFDYRCISFSEAKNILNDIIHSITNRIKLNHSLAKMLLIQCKWDANEVLNKYFACDNEYFECKGVKPFHKSWEDSIAKAWQYECSCSPTAIQSEQNQQASSLSLLMICCDVCLDRDFKDHFLSLICGHSFCHDCWFNYCRVNVQNGQSTGIRCMNSDCQLFLPEDFVHFIFKKTILLREKYDLLSFRESVDSYIRMRLCINSECQTVIAAQEQPASKRVTCTNCNNSFCFQCGNDYHAPTDCKTILLWYRKCADDSETAHYISAHTKLCPNCSSCIEKNGGCNHMSCYSCKHEFCWICLGTWDIHGPQYFKCSKYKENLDIKNESERAREALKKYLFYYERWDNHMKSLKLEDENRQRIQAKIDDELNRNNGTWIDWQYLLRGAKILSKCRYTLQYTYPYAYYMECGPQKELFEFQQAALENEIENLAWKIENAETTDRGALENQMTIVEKRRTTLLYNFFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L034</accession>
    <name>A0A922L034_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial-processing peptidase subunit beta</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DERF_012367</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L034"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="60"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="213"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9501526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="476" mass="54622" checksum="6C62199FF1FC872C" modified="2023-02-22" version="1">MSYRNFIRHFNRNVRLIKPTVNKKLVTFENNGRLLHQHHHQPEILNVPETKVSTISNGIRVVTEDSGIPTCTIGLWIDAGSRYETLENNGVAHFLEHMAFKGTQKRTQMQLELEIENLGAHLNAYTSREQTVYYAKCLQNDIKQSLDILADIIQRSKFGKEEIERERSVILREMQEVENNLQEVVFDHLHDIAFRETPLGMTILGPIENIQRINRNDLISYINTHYKGPRIVVAGAGGTNHDQIVELVDSYFGDMDRDASNIRPEPCRYQGGDVRLNDPSMNLIYGALAIEATGWINADNIVLMIANTLIGSWDRSLGGGFNSFSYLAQTSIQQDLCNSFQSFNTCYKDTGLWGVYFIGDKTKTNSFIQHLIRQWQQLCTDVTEEELERAKNLLKTNMMLQLDGSTQICEDIGRQMLCYGRRISSIEIESRIDSIDLDYFRKICQQYIRNRPPVLAIVGATDSIESYDHIEQSMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0X8</accession>
    <name>A0A922L0X8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EMC2</name>
        <name evidence="8" type="ORF">DERF_009486</name>
        <name evidence="7" type="ORF">HUG17_7386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0X8"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="6">
        <location>
            <begin position="80"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7637180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9510999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="305" mass="35033" checksum="D54896870B401542" modified="2023-02-22" version="1">MDPNKFESCDEFVSKLSKRESKELLQKWREENARNSELVRQIWLTKDLGSYLGDEKWVVLEQVCVAAMDLHDKTLIESCITQLLNKFPNSSRVKRLRMMAKLELTQRYDDAIAKYNELIANDESNSLLHKRKIAILIATRKNHLAIKASCDYLKNFMNDHEAWIQLSEFYIQEQEYAKAAFCVEELILSNPHNHLYHERYADIQYTIGTGDSLELARSYYAQATKLKPSSLHALYGLILSSNALATSPKTTASKKKEYILLAQWASNQISNIYKKNLSSSNSIEKANERLIDNIDSALEALSISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L132</accession>
    <name>A0A922L132_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_013944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L132"/>
    <dbReference type="OrthoDB" id="6510469at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037690082" evidence="2">
        <location>
            <begin position="16"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9498017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="305" mass="34617" checksum="F302B1BDA285F532" modified="2023-02-22" version="1">MLKLILIFLIGIAYATQTRIKIGSKSWAYQIDLNHGQQIRNEFSNEDGVTSGFYLFRNEQNQTKKLQYTIDPNRNQPDVEFDVINIANNDEMMADHNQSGCVRPNANLTFDSIDSNEDFKGHVTLKVGNATYSINFATGDKSNSREEILTPTGLLYGRYNFMPKNSQNKIVINYKFNSTSVDPTFEVSLFKSSELETISRDYHPRERDYYHHNNINYNPNRAPYQRGYLPATSSSSSSSGTSAAAVAGVLSSSHRAAIARAQEQARQAALAEKYRNNKNPQFQYHDSLSTTIPSWYYNRSKSNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L153</accession>
    <name>A0A922L153_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SNRPD1</name>
        <name evidence="14" type="ORF">DERF_009680</name>
        <name evidence="13" type="ORF">HUG17_7529</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L153"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7637323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9511209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="128" mass="13671" checksum="F28D21FC93941FCE" modified="2023-02-22" version="1">MKLVRFLMKLSHETVTVELKNGSVAHGTIAGVDVAMNTHLKTVKLVNKNGAQQTLDSLTVRGNNIRYFILPDSLPLETLLVDDTPKAKAKKRDMGRGGAGASRGGRGRGSRGRGRGGIGRGSAPPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L238</accession>
    <name>A0A922L238_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L238"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="93" mass="11140" checksum="962A71DD414AFCD4" modified="2023-02-22" version="1">MNKLFNKWMNSNELQLIVNQSTDNDVYVWLHPKKNQMNVAENTKKNYLKFCNLIASSSSHHQQHFKYPSDDDSNKQDMFVVLYDTKRNETKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L244</accession>
    <name>A0A922L244_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RCC1 domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RCCD1_1</name>
        <name evidence="3" type="ORF">DERF_008991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L244"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="2">
        <location>
            <begin position="18"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="267"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9510471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="336" mass="39062" checksum="3EB709D975EE65DD" modified="2023-02-22" version="1">MNDDNLKILQSPIIKYRVANIFHQCPMLLGDPNIAIRLNVLKLSYISMKLLRSYEGNIFSIILDILLPYVHRFWDSLVQLLPLELEHPVVVKNAFDCLMLANKLCGDFLLRRTGKKIIPALINFLQIRFDSRINYYRKHGHNETLKTMDYYIELELLRSLGRLAVNVKLRSQDIWKMLPIFILYTCSNGIIMDLRQNSLELLIIISDRADYYSVRYFVHIFFEIFYENPGLSILRPNQLSNQCLIKFQCICHRNPGSRHSMAVSENGILFGWGWNKYGQLGIDSTAIEFADAPNVIPFDHKVSNVYCKFWSSLIETENDDSEPQSNESAITNNNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2L6</accession>
    <name>A0A922L2L6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase makorin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MKRN1_4</name>
        <name evidence="6" type="ORF">DERF_010471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2L6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="210"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9512062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="336" mass="40125" checksum="4FE1DCA1BAC5E0BF" modified="2023-02-22" version="1">MSYHNRNSNSRGLSNENENNDEHWNVNHDNDVINEQQRPRLSAIETFRLTTANYRSSSRYNRLNSNLNFRNQSLQSSQVNEMTITRRNNNNHQKSINQHLSPEQESIREILRNFCCPFNEDGNCRYIHRPEYCNFSHPNHAEESSYKRLPSFLCIFNLMKKCHYVVFGDKPRCSDGFHLDAHDLFNLEQFEIENQRAIVGFYYRYCVQECMICAEKICEKQFHKKRCWALHENCSHFACITCMRKWRERSHLCPMCRVQSDRYIWSNSHRIYDENHKKSLFENHGHRQIVKDPPISVPRAEPLNFDDVEIIYSIEPDGNIVYLDLPPEDEFDDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L385</accession>
    <name>A0A922L385_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">oct-1</name>
        <name evidence="7" type="ORF">DERF_010140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L385"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="106"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9511701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="651" mass="74466" checksum="EBBEC71271B6238B" modified="2023-02-22" version="1">MKFEDILQQIGDENRFQNFLIIFLLLPTSFFNVFFEGMFLLSTPDHWCRVPELEHLSMEHQQHLIRPIDPITGKRSNCERYDVEYKDFLNTINTNNNNNNDLHQDIKLLISNSTIQTFAKIQCNNGWIYDQSLYTETAVTWFNFVCNRDYYVNLIMSLTAIGLAVLTPLLSNLSDSIGRKKAMLITMIIAQISCLSPIIFKDIYSFLIARFLAGGILCVYYQLPFVITQELVSQKYRTLASSLSAIFYSLGSCSLTLALKLTGNWVTFTWVQFIFTSFLIIAYKLIPESPSWLISKKRYDEAYEQLAQVCRFNKRKVPDDLMANIMSLESDEDELKSTTTTTTKITEINNDNENEDSFFDLILMPGLRSKTLIITIVFIACIIGYGGIIGNTVNMEANNQLYNYLLLSFIDLPSLFICWKLINTRLGRRWTNVITMGICGIALILPAIFNRQYDEYFYTGCTLVGKFGVAGTFMIIYQHSSELYPTTLRNQGLGLTATIGSIGAILTPQIVYIAKYGEWIPLFIIGILCLLASIIASFLPETLNEYLPQCSREAANFGRDKKFFTMADLKNRKLSITKKTTTISINNDDDGEKQKQQQQTSPKTLMKIFSNKNSNDYNSNCNHQNNNNNNNYYYYHTSNNTTTIITPIIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L398</accession>
    <name>A0A922L398_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DIS3-like exonuclease 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DIS3L2</name>
        <name evidence="9" type="ORF">DERF_007075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L398"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="8">
        <location>
            <begin position="350"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9516326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="862" mass="99757" checksum="62F66FE27160890D" modified="2023-02-22" version="1">MSSSTTTAATTATMMTNATKNSSRKKRMANYEEYLPLCEMQKGLQKGEIVEGILRINQRNYNDAYISAPDGGLDIYIKGLIDRNKALNGDLVAVKFLDETEWKISYTAINANWEEWKDDFMRLIMANNEEIDLSKLKLNSKDMGLISMGSKSTSSPMTNETSKQLLLDEFENLPLEIFTLQNSIVKEEISYWPRLIQRTGKVVGILKQNHPRMFAGTLKFDENNDNNMNQKKKKIENDNKYVKFTSCDIRNPQLIIPIQTLPEFLLKDHIKFKNHLFLAEITDWKSDSLYPSGKIIKNFGKMGDIDVETEIMLISFSINKDDFPDQALAEYQEIFPDKDWHIPETEIEQRRDLRKECIFTIDPETARDLDDAISYRQLSDDRFEIGVHIADVSYFIKENTLLDLIASDRATSVYLVSKVIPMLPHIFCQDLCSLNPGQDKLTFSAIITVNNYGQVLDRWFGRTVINSCCKLSYELAQKLIESDDDNKLDESIFPQLYGPWSLSEIGQRVRHLHIIAKTLRRNRQESGSIRLDKTKVSFMLNEEGMPLALSKYKLRESNWLIEEFMLMANKCVAEFLYDKFAPEGRAFLRCHPSLDKFVLREFLKSIKDICPIEFKSECSRSMVESLEKLADIDRNFCQMSTMFLIKAMKLAMYTCVSDQDNPLSYHHFALNFSTYTHFTSPIRRYADIIVHRLLSVALGYESSICSKTNEELKKIADHCNTKKYNAMLASEKSTEIYLKAYISKIGSLTSKAIVFQVYDHSFDVLTLTFDTINRIYLDQLYIDDYQFIRDNSKRELKLKWKPIDKQSMPDTCSETLSDDNKMNLIQTIKSFAILDIEMIVTDKFEFKVITAHPNGKFIYNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3J7</accession>
    <name>A0A922L3J7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3J7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="103" mass="12454" checksum="1979BE292527F22B" modified="2023-02-22" version="1">MDQMAELVLELELSMFRMMDRMAELELSMFQMKIDQMVELVLELVLAMFRMKMDRMVELVLEMELSMFRMKMDQMAELDLELELSMFRTKMDRKVVLALELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4D6</accession>
    <name>A0A922L4D6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4D6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="89" mass="10477" checksum="4F810F1944F6A720" modified="2023-02-22" version="1">MDAHVRFRIIKSKLFIFIIDNVRMMAINSKNSNNCDGKLIIHTGSVSLHNDKPQRFSILVRKIKNRGQEQIKRTEFWVCISHQHKDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4R0</accession>
    <name>A0A922L4R0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4R0"/>
    <dbReference type="OrthoDB" id="6516977at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038011986" evidence="2">
        <location>
            <begin position="23"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9518233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="287" mass="32513" checksum="A91A672E9797A30D" modified="2023-02-22" version="1">MDNRLICLILAIQFTIISSSSSSTIFDENKLELGKIIKNSAKYLLKNHGHQLKQSGRATTTSQVIEYNARNIVLMTLLNSVLILGGILGSLNRPDLPFNVLGSGNGASLPFKRIDLFKKRLWPKRTNHKPNVIIDDQAVQMEALVKDLMNKNKHFEPLSNDIFPRMLDTIKRNDRRRSDNSDSIDTEEVTDIDPTNCALLIQCTDAKGKPYYPTLSSLTKTAVQLVNTSHENDNEAKKSPSKIKTKKSGRSLIRRPKMLLDQVQEMIEIEQKAKCQWKELCQIEIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6R5</accession>
    <name>A0A922L6R5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6R5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="121" mass="13645" checksum="BAF84A8E18AC9A7E" modified="2023-02-22" version="1" fragment="single">FSPKKKKKFVDDYAMQMLMQQFTLLPFFGMIRAGRGACADCAPHKASRCLRPFRCTTQGLAAPTFQAIFAQGLAIFSAGPGYDDVVMVVISFDYCNQNQHFTFNFTGMLNLEFEGKEDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7L9</accession>
    <name>A0A922L7L9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ADCY7_1</name>
        <name evidence="19" type="ORF">DERF_005893</name>
        <name evidence="18" type="ORF">HUG17_3197</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000032">
        <property type="entry name" value="Adenylyl cyclase 78C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF12">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="876"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="948"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="974"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1031"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="364"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="1119"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7639164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9522308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1323" mass="149780" checksum="21D2A2D04091153C" modified="2023-02-22" version="1">MNINANCFTSSFMANPKTTTTTIIGNNDKLLSSCANNNNNNSNNGSPPYRQYILATVFLIFWLWCTFLVHRILSDIFYHENYWSRSHHFHIESMDIDLLVAVFSIIYIQSVLPFNPYINLAIQFICFALYILMEIMQIITVFNDDRLRMIIQQQQQRSIINNNETSSSSSSWQQSHQQQQSLNDSHGFNEYIVKKILTDILILLAFITYTTDSRRRMEQENCDTFAGARKIIDDRILLEFEREQQEQLLLSVIPAYIAAEVKRRIMDKMDVDRKGARAEMEKQNNNNNQKSTKTATTANVTNIKTNFNQMNSGGKNRRESHAISGSNQILSGNHRLAGPGDLLPKTPQKQRFHELYVQRHNNVSLLYADIVNFTPLSEQLSASELVRTLNDLFGRFDELAQENQCMRIKILGDCYYCVSGLPVSRPNHAINCVQMGLRMIKAIKMVRDATGVNVDMRIGVHSGNVLCGVIGLRKWQYDVWSDDVTLANHMESGGVPGRVHITEDTLDRLDNRFEVEPGNGHLRDSYLAQHAIKTYLIIDPTKSKQDTLDTKSIADTGNNTSNDCALSSKRRSSLQVDGSIIHNDLINCKNNDNQSSQTNSSLTNVSKVQRKMGPGVGSKRNFSKWTECGSSGWAVDKPFSNISESVIAKNVTQTSIALVEAVLTPTPQSLMDTLRSWFSCCLPASELQHYHPRKAEINSIFLHFKDSSLENPYERHAFVGNFPTNSLNVTILMSVLAIIEFILLPINIFTLTLIISMIIIALTFTISILIQSIRNHQVPLTMLPTRFSTTFDQYNNNGANNTNNIGTNICDDLETGSNIGNTSITHHNTLQQQQKRMKIFEWYQRLGMVMGEKLDFIHVSIRNYTENFLSCHQQSIMLFSLSICSALTIIMITIEHCLTFVPSIVNCDDVPIPIMMIMTTATGSGDTIPTITTTLNEHQKCQLELRHYFRVSSVIVLMLISTSLSHLKHTYRILVQIFYFGILAILNILAVGNSGTNAPSMIHSTNISLDNQNINDDHNIMDTTTEEATPTGVYGATILFALFFSLILYVRDRHIEFSSRLHQLWKAKLQVEQEDVETIGGINKILLENILPQHVAQHFLLNNYGPNRTLYHERYNSVAVMFASIPNYHEFYDENDVNKQGLECLRLLNEIICDFDKLLLKPKFSCIEKIKTIGSTYMAAAGLQPGRESFEAGAKEGSFKLHREEHNVISLVEFSIALNNVLQQINRESFQRFRLRVGINHGPVIAGVVGAHKPQYDIWGNTVNVASRMDSHGMMGKIQIPVATAKLLMEHGYDCECRGRIHVKGKGELETYFIKSPALKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7S1</accession>
    <name>A0A922L7S1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_006492</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7S1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2320:FF:000001">
        <property type="entry name" value="phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000178">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040724">
        <property type="entry name" value="PheRS_DBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040586">
        <property type="entry name" value="PheRS_DBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18552">
        <property type="entry name" value="PheRS_DBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18554">
        <property type="entry name" value="PheRS_DBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="236"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9522939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="525" mass="59834" checksum="306855AA0A5579FF" modified="2023-02-22" version="1">MSDQELSQLLLEKLNLLQSPVVKINSLDFAQENQLDHQKVVGAVKSLQSLGELIKANQVESKRFELSNEGGQIVENGSHEFRVWSTIPMDGSILQSDLMKSIPDSNVARLGFAKAMSNKWITLDKSSGKPMVKRNASNVKDEIRVLLKLVQSGAATKLNDAQRNDLKKRKLIQEIVEKSYDVHRGSNFQTTIEKPETDLNAEMIAKGTWRTKTFKEYNFNALGIAPDRGHLHPLLKVREQFRQIFLEMGFEEMATNNYVESSFWCFDTLFVPQKHPARDLQDTFYLSDPAECKDVPYDYMERVRAVHETGGDCGSIGYQYEWKESETRKNVLRTHTTAVSARMLYKAAQQYQNSGSKKFRPIKLFSIDRVFRNETLDATHLAEFNQIEGVVADRNLTLGHLMGMTKAFFEKLGIHDIRFKPTYNPYTEPSMEMYSWHSGLGKWVEIGNSGLFRPEMLKPMGLPEDINVLGWGLSLERPTMIKYGISNIRDLVGHKIDLQMVYGNPVCILEPRQQQQKPVGATLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8B4</accession>
    <name>A0A922L8B4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SERine Proteinase INhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SRPN7</name>
        <name evidence="7" type="ORF">DERF_000457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8B4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF342">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR 28DC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037081245" evidence="5">
        <location>
            <begin position="24"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="102"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="526"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9526359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="580" mass="64754" checksum="D0DF231BE6B98CE2" modified="2023-02-22" version="1">MTNPNMTMTIILFVFLFANVATANIHHHQRSSIVSTNPIVAKSSQWQGIATTSNQSTTLSSSSSSQQQQQQPQRVQTTTATTNSNEQWIGNGHLQFTFDLLAGIFMNSIDLKTGNLDSVVFSPFSIQSMLMMIHLGAKGVTKSEIAKILHLDSLENNVTFSKTHEAFSQAVKSLIDDVNISKSLHSANQIFIQETLQVSNTYLSAVNHYHLSSIRYLNFAKESYQVLNTINDWIEKQTQHMITNFLTTPPSPATTLMAVNAIRFKGDWQYRFDPSDTEKDAWFRMINGQVATVDMMVAQHPVAFAYSASLQTSIIELPFKMQRLSFFLLLPNDTFGLFSLLNSLNATVFADLIYSMRKVNSGDKTFGGSNGVNIRLPKFTISSMPRITEIMKTQMGVKSLFSTESANLEAMFNRYSGHIHMGDLLHKAVIKIDEQGSIGAAVSTSSIERIGAFNGPYFEADHPFIYLLMDKQTGLALFAGIYAGPGKEDQQQDSTIQKSKTLSTTKTIMQSNNNNNNLQQQINTVKNSNQQPPSSASIQSQSSSYHHHHHHQRLHLNQYTFGMTPDGSNVDNNNKMKYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8L6</accession>
    <name>A0A922L8L6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8L6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037139584" evidence="2">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="289" mass="31927" checksum="58697DA6700CD6FA" modified="2023-02-22" version="1">MKLTATLLLILTLSWAVDANPRFKRDNRDDVLKQTEELIKSAQDVLEKLPDSDLKDEIAEKLATMKHYKHELENAKNPIKIAHFELELLTMFKKFQSLLNEANEIIKSLTTTTTEPTTPTPEPTTPTPEPTTKTPEPTTKTPEPTTPTPEPTTKTPEPTTKTPEPTTPTPEPTTKTPEPTTPTPEPTTKTPEPTTKTPEPSTPTPEPTTKTPEPTTKTPEPTTPTPEPTTKTPEPTTKPEPYPTRTTTKTEPHPTPEPHQTPEPTTKTPEPTTPTPEPTTKTPEPIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8R4</accession>
    <name>A0A922L8R4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPL4</name>
        <name evidence="8" type="ORF">DERF_000540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8R4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="228"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="331"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="704"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="908"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="704"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9526448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1256" mass="140909" checksum="7F9075100624F3D7" modified="2023-02-22" version="1">MVDIDQNFGGNENEMDFDMMFDPSYTNKPLNVTVRSMSTTSISIHWQSPYEEPQGYKIKFRLKGNKKQETIVLDSSNYHHELKNLEKATSYQIKLAAIYGNETGPFTEWYTVETLQRDLDETQVPDQPGSLRLKQDHSSIHLSWTPPKNRNIVVRGYTIGWGEGVPDRWTWRVQGGDQRSYTIENATISTEYVISLRAYNLRGEGQPIYETIKITFDPDKDDQFVMLPPIGLKTTVISSSAIVLDWTDASRDSSSSIHQDNRFYLIRYTNIIHSNSPRYRYANTTKRTFLVEDLKPKTQYEFSVKVIKNKRNSTWSMTIMNTTHEAVPSTPPRDLTIVPSSNDDPTTINIHWQPPKQPNGQITGYVIFYTQDNTQEDRDWIVKVIFGDKLNAMLNGLQSSSVYYFKIQARNNKGYGPLSSEVSFRTLPATMKTHTTNGSDIQINLFSLIIIIISCISIIFLIGILKIYICKNDKTNNETMGKNRKGYIPTATSPGGGGGKNTNSRMMNNIRNNNAGTGGGGGMMEKPPDLWIHHSEQVEMKLMDKNNGDNDSNGGALSVKNNIEQPFAKIKKTNSTYGMNTALYDDINSNKSPSSPIDNIGMATMRRSSSIRPKTSTCMDHSLMNMSMMNMEPSTGLSRPLYPKTNQFNIAHPMDTMDSASTMAAPFHHHHHHHLYDPVPGSGAGGHIALTNLHESQLVHSVNSSNSYMSSGNSSSPHSVISNNTVLTNSSTGTSNLTNSSTSPPNTSIYLSNSRQPQKPSSSMMMVPTAASGNAVSHSALKSFGVPTPPPALPSLATLGGLQNNSHNSFYNTSLGSPSKKFLLTTTNNLNTNNNICGSNSTLASNGKSATNFSDDHSISATAAYRPLISVYNEKNESTGTTIKLPAVFRAPIRTDIVNYVHTNIRKNRRQPHAVSREAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFGPIRVWRRWYRKVNRNQRRYAVVSAIAASGVPSIVMSKGHVVNDVPEFPLVQELNKTKQAVEFLKQVKAWSDIERVYRSKHFRAGKGKMRNRRRVQRLGPVVVYGTDSGLTRAFRNIPGVELMNVEKLNLLRLAPGGHVGRFVIWTESAFRKLDEIYGTWKAESKQKRDYTLPQPKMANTDLSRLLKCDEIQSVLRPRITKVVRRSVKRNPLRNPLVMRRLNPYSWVLKTQARANNLRRRRAKEILRRRKAGEKVDQKSLDKAVNLLGIKLRKYKEYKLERSKKVATKKEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9A5</accession>
    <name>A0A922L9A5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RPLP1</name>
        <name evidence="9" type="ORF">DERF_006031</name>
        <name evidence="8" type="ORF">HUG17_3119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9A5"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7639086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9522462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="119" mass="12116" checksum="420B439386F25A38" modified="2023-02-22" version="1">MSINELACVYASLILQDDDVAITSEKIQTILKTANVDVEPYWPGLFAKALENIDVKGLITNVGSGVGGAPAAAGVGGAVSAAAAGGDGAAADDAKDKKKEKEAEPESEEDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA65</accession>
    <name>A0A922LA65_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA65"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8097" checksum="586CDB461A93C6C9" modified="2023-02-22" version="1">MMKILTLLSIIESNNKSAQLFLINGNYKCYRMMAPHLTKTLSAMANTPQFSMIIANGIKSQDLQNNNLFTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAI0</accession>
    <name>A0A922LAI0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_002320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAI0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037481663" description="Peptidase S1 domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="74"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9528368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="407" mass="45464" checksum="59F972D6C5476B98" modified="2023-02-22" version="1">MELLFITLSSLYLISMITALPTTTPEPRITTLFGLDSDDITTTVTMEENAIDNFNYINLNECNCGRRMTRYPKIINGSNAVHGNNPWMISLLLNNRHHCGGSLINGRWVLTAAHCVYRVPSSRFRVKLGSHLRSNNNTEPMSTILDNVLAIAHPGFTFTTFQDDLALIRLPETVSYTNYIRPICLPDQVTARQIQKKATVIGWGKLKQGGASAETLQQVDLPIIDNDKCINWYREMGKMLTIRPTQICAGFEEGGKDACQGDSGSPMIITDNYSKRSTVIGVVSAGIGCALPKLPGIYTRVSAYLPWIQKTMKRYDRIYNEKPKLPFSPAAISVNNDDVITTEKPEQIVMTSTISELNDETKEPEHDNLWALVSPTPSSQLQLIETNETMESENNKLWTLITSSPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBG0</accession>
    <name>A0A922LBG0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBG0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37703" checksum="77D6F8D19C2F0FE9" modified="2023-02-22" version="1">MTSPVNEQEIKINSRLDYLESMKSKLRKKITEYHKEIKNNTFSITDLIVKTHKLSDTIIEYNEELTKVVDLSDKKKSRSKQKNYHEKVKKYCYICSRSTHSTMDCYSKIPPQMKKEIILTNNLCLNCFEFGHKAKFCFSPRRCLNCKNKHHVFFCNVGVKHEFNQTTKQSTSKLNQQTKPMLTYNQNKNIQNVQNQKNQNRLAVVPRQNYLVTTPEGSESANDSDSESTIGLHGFEKQSLMAFKDKKINEDIKNLLLPITVNGMVNGRKQKFILDTGSNINIITPKMCEILNIPIKNYVEIIETIGAQTKTTHICHTKVSIGEISNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LC77</accession>
    <name>A0A922LC77_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate [NMDA] receptor subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">GRIN1_2</name>
        <name evidence="29" type="ORF">DERF_002790</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">Derf</strain>
            <tissue evidence="29">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">Derf</strain>
            <tissue evidence="29">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a heteromeric NMDA channel with Nmdar2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LC77"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000010">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000009">
        <property type="entry name" value="Putative glutamate receptor ionotropic NMDA 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018882">
        <property type="entry name" value="CaM-bd_C0_NMDA_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10562">
        <property type="entry name" value="CaM_bdg_C0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="24" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="14 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="15 29" id="KW-0675">Receptor</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="8 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="27">
        <location>
            <begin position="448"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="28">
        <location>
            <begin position="469"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="909"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1052"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="971"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="759"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="23">
        <location>
            <position position="691"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="23">
        <location>
            <position position="721"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24">
        <location>
            <begin position="771"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAH9528882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1088" mass="123990" checksum="79569843FC61473D" modified="2023-02-22" version="1">MIIKFFKICLTSNFFQQLSSSLCLVIYLLFLNLDQRKSSTVVDAQRQYHIGAVLSSAEQVVQFQKIIEDINYEGDILPYGVSLHGHSILKQTNPIDDTRNLCHNLMPFEIYAIIIDDTVPSNAITFTSSLHNIPTIGLANRECLFSDKSLYGSYMRTTPTYSNQADVWVRIPIMRLLTHLDFECAHFIVSDSINGRDIKTQFITLADINNLEIESIIEYDFSRPILRPDLEAIKERNSSCRINVLYCLSEIIGLNITGADNIWIVSEQALYAPNLPIGFLGIRYKDQSNIQSHIIDSVYVISNAIKEMRSKINANLTMPPGDCRNIGRSRWTDGDLFYDFLRGQTIIFGKTGKISFDEHGDRLNGHYEIWNQQPNTNPNRTSNNRLVNVGQYYYNQSAMKMTIDIDEKKIVWPGNKTEKPISYSTPAHLRIATLAEIPFVWVLPVNEHKGCSAGQVPCPIRKKNGKTGLYYQETFCCEGYCIDLLIQLAAQLNFTYTLHQVEDGFYGSYRFNDKTGHHEWTGLLGELYYDRADMVVAALTITPERSLAIDFTKPFKYQGITILQKQQAIHRLGHPLTSFLQPFQNSLWVSVFVAVHVVALALYLLDRFSPFGRYKLPNCETITEEDALNLSSAIWFAWGVLFNSGIGEGTPRSFSGRVLGMVWAGFAMIIVASYTANLAAFLVLDRPQTALSGINDPRLRTPPDGFNYSTVRNSAIDNYFKRQVELKLMHQRMSEIFFNNVEDAIAAVKSGTLSAFIWDSARLEYEAANDCELIISGEHFGRSGYAIGLPKDKIYWKDKVSLALLGMHESGFMEDLDQKWILLNEQVCSIRTEHFPPTLGLKNMAGVFILVATGILGGVGLIMFEIFYKQHQTRKQKRMELARNALDRWKEMVQKRKLRKESLRMAAQQRYRDQQVLHRRRQQLRHSSKSLSDERFSTSSSIEITDPHGHQHYLQQQQQSQQSERCNNLYNDKHSDSRHGEFSRPSKPTYLELKHINTSILPSSVAAQQAHPPPTLTTSRRMFEQEQHPVASARIYTKPKLRREFSIAYETSDNTGSAGEDPNFSQRTSSLSSARTTEKYGSNFVNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LD52</accession>
    <name>A0A922LD52_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001933</name>
        <name evidence="2" type="ORF">HUG17_6902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LD52"/>
    <dbReference type="OrthoDB" id="6492612at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7636696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="151" mass="16331" checksum="63B60C4B961A5922" modified="2023-02-22" version="1">MPSSKHLNYYGFLGLFVCLATAASFFILKNADCNIGTGQNYDKLSPIQIAGIITGGILFILAFFNIANVLYDIKIVFFLVVIAILGVAGVMFWGAYIAFSEPCKSVIGINTSIFSKNAFEAEDGNNIAVMFLDIIAGLMLCSVGFTFAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDC5</accession>
    <name>A0A922LDC5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase arkadia-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_002562</name>
        <name evidence="6" type="ORF">HUG17_10523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDC5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7636553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9528640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="9929" checksum="0EF37F353D465DB5" modified="2023-02-22" version="1">MVLLLWRRLPCLHVFHIKCIDKWLKQNKKCPICRISIAIDYEKIFSLLNSGISIEQCLNQQESSLGSNIASFLQDFTDLQQLVYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HIC0</accession>
    <name>A0A922HIC0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_014503</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HIC0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000009">
        <property type="entry name" value="Aspartic proteinase A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037587895" description="Peptidase A1 domain-containing protein" evidence="11">
        <location>
            <begin position="23"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="77"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9493774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="402" mass="44677" checksum="7805D3749BEB10D8" modified="2023-02-22" version="1">MKLIVLSSLAIIMMMMANMAIAKELFRIPLQHTQTFRSRLLEVGTNVKLALLDHHFHHWTKYGPFPEPLSNYADAQYYGEISIGTPPQKFKFVIFDTGSSNLWIPSKKCSYTNIACMLHNKYDSSKSSTYKANGTAFEIRYGTGSMTGFLSTDTVSISEIAIKDQTFAEAVKEPGVTFIFAKFDGILGLGFETISQDQVPTVFGNMVRQGLVKDPVFSFYLNRDENGKVGGEIIFGGSDPNYYDGNFTYVPLSKIGYWQFNMSSVNIENKDDKIVGHLCEYGCQAIADTGTSLIGGPNEEVDHLNKALGANGPIKGIYTFNCSKINDLPNIVFKIGGKNFPLTPQQYVMKMQALGQTACISSFIGLPPEIGDLWILGDVFIGYYYTEFDYANHRVGFAKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKV6</accession>
    <name>A0A922HKV6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9496971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKV6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9496971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7921" checksum="5671CD8CDEBCA0F3" modified="2023-02-22" version="1">MQKHLLGAALINFQWGLNQKIANIDMKIPKKMHKSCYYRKTAANGDCEFLVFLWGFMAIPTRHSPFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKZ4</accession>
    <name>A0A922HKZ4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKZ4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="78" mass="8869" checksum="A6FCD05C11DC7A4A" modified="2023-02-22" version="1">MEDSSQKKTKLSNFEIVFRKSSNEIQYSHHSNPISTQQSVLITRISVGGGIICIREYLKHLEIIESGSNTLSNEMKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HL30</accession>
    <name>A0A922HL30_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endoplasmic reticulum resident protein 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ERP29_3</name>
        <name evidence="4" type="ORF">DERF_014119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HL30"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016855">
        <property type="entry name" value="ERp29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012883">
        <property type="entry name" value="ERp29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12211">
        <property type="entry name" value="ENDOPLASMIC RETICULUM PROTEIN ERP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12211:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM RESIDENT PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07912">
        <property type="entry name" value="ERp29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERp29 N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9493367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="322" mass="38135" checksum="3C0FE9FDEAC467B2" modified="2023-02-22" version="1">MFTLSAHCYYDDDETIDLVSLMLSMIIAVDQCCGQHYLGVIESDQLTFDLIASRFHYVLVKFDHLYAYGSNQDVFNQLALDTMNNTGREDIIFINLEVKDFDDHQCMDLVNRYGIEKKQFPAIRLFINAEQFNVEKFKTIKPIEYPVQRNQSNRYQPDKIILDPTRLRLFLRQYTTIRLLLPNCTEYLDRVATEFVHTLNNGTFDEQNRIIDKMKMMAKQKLNNDDNLYGWKQLNQYIFWMKYGQKHSDGGGDGNSAKVYDDQHERLKSILWNENGHISWTKRQQLQVRFNVLQSFRLTNDEQQNDDDGDNDTIDSHRKQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLH2</accession>
    <name>A0A922HLH2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLH2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="170" mass="19086" checksum="23BCC1E0D3EB503A" modified="2023-02-22" version="1">MFSSSLIRSVGSSSSSNSKRKTKNQSKQPITTTTTTPSTSKQRLSSTTFGRISIVGDIIERTTRLNKQQQQQQQQNKRVMNTTTNTNDGIDNQLNFDDDDDDNDDNNRQSSSITIINGNKKNVSISDRCDQLLFGVEPKTIDNYDESESAIMATTTTTTQQQQQQQQHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HML3</accession>
    <name>A0A922HML3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HML3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="122"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="941" mass="107033" checksum="A3B32EA5F744E8BA" modified="2023-02-22" version="1">MITEPPIRKGIPNIKRKYNPLYATNSNVIHHLNNYQPNHHLNVSNLQPSSSSSQSIQQVRPSQQTNSAGLGPSDNSNSSNQPMTNNQQASINNANIIQQPVRSCIIILNPLLPPIIISSVSNTDFITIEINSFVFASVYSQPENNAYRPIGLLSTMGKAFERIIANRISGHLLNNGHLSTSQFGFVAGRSTDHAVYNLNRDIESAMASNNHVALISLDIRGAFDHAWHPFIISQLIDYRTPIYLIKTMANYQMDRRICGSHGGVSFCKETNRGVVQGSMLGPLNWNIVVNNLLMKNLGPDIKMQAYADDIAIIVSSKCQTYLPIKINNVLKLAYEWGAKCKLTFSEAKTQVMFVTRRINRPIYSPVIMNGIEIKPVEQMKILGVIFDHRLDYRPHIHYAVSKAVKVYRAVNSIARKTYGLGPRVLQLIHHCIIEPIITYGAVVTRRAVQYQHVIKELRQMLKPMAQKATMAYRTAPIIATSAIADFPLIDLLINYRATVVNARVTKLYSHLDSDIPVDIEEVRETSADVRINFILREPAVFPPIRIFMKSILTNHGIGTAFMAFNQNNRIITKSYRLPVYCTLQQADFFCISMAIEWSSVNLGQQATYIMTNNIGTVQHLKRTDHRKTQRLANIITTMANNNITIMWHKVDRENRWYRNLKQLARRTGKHRNRNYDYDRIQMNVIKKLERRNMLAEWNNKYTNDRFGTTIKTICPQLGDARQFSRVINRFLTQTLTGHGQFGSYLARFGISYDIACICGFPVQDVAHLINDCPMLNRLRNDFWLASRTTTDPISKIEKRAIFYANIAIFADVNRNAIHQLRPPFGTTIKTICPQLGDARQFSRVINRFLTQTLTGHGQFGSYLARFGISYDIACICGFPVQDVPHLINDCPMLNRLRNDFWLASRTTTDPISKIEKRAIFYANIAIFADVNRNAIHQLRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNL4</accession>
    <name>A0A922HNL4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNL4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="129" mass="12161" checksum="A796E0582C63D06F" modified="2023-02-22" version="1">MANSTSVTTGQNKVQNNDSSTGGSGSSGGGGGSGGGTTNTTAATANATSSSSTSAAASTAAAATAATSSSSPSATTTTTTGQGTTTGTGQTAATNSSNTATTNNANQKLSTTDRIIKTGAYVFRLFDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNP3</accession>
    <name>A0A922HNP3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_011956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNP3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="444" mass="49477" checksum="D9567373D75D2108" modified="2023-02-22" version="1">MANQDSNDEYYSYSKLEKFRRCERHFRSVQAVLLLFMVVCFVFYMITFGIDIAKFLNDPPLLAASLTIVIVAMIFLIIGIRGVAFESFCMVLSFTIIFFLITIAHGVTFIYRHPGLTATNLVLALLLFIGAIIYLCYLCRMNRLKPPDYGKTTAGGRTGNDAADDDDDDTESSMALTSPQTDATIEKIVTNVKSGFTDLNRGLTDSGEREYGRIKREMGNFKTGIDGEVETVKKEFANLQTAAGENVEKEFIAVKRVMLNEAQTIRDGVEREYDNLRIGLNDVKRELGENLQREYTVVKREISNDMDRLVGDVKGRYGDLEKELRGSFKSNLGDIENEFNIFQREFPDTIGADTGGGGDGTGGGGGDDGNNSTTIQRMVTNVRKGFEEFKSGGENVKREIVEVKRDESGNITSYIERRLTDSGVEICSVSVDKNRAPIANFTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNP4</accession>
    <name>A0A922HNP4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNP4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9498037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="8796" checksum="C7365F6A7CDA086C" modified="2023-02-22" version="1">MKIVLCLYHVFVYGCLCQFFYNGGYSKRDIHSLETRSEMKLFFTNIGKLYKSTPEYCNQEKYFMLTISTYLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPK7</accession>
    <name>A0A922HPK7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Calcium ion binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">Mmp1</name>
        <name evidence="18" type="ORF">DERF_013160</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="12">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPK7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000022">
        <property type="entry name" value="Matrix metalloproteinase 1, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000007">
        <property type="entry name" value="stromelysin-3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF291">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 1, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="17">
        <location>
            <begin position="72"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
            <begin position="263"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
            <begin position="309"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
            <begin position="355"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="14">
        <location>
            <begin position="48"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="13">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9497156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="559" mass="64040" checksum="27AF1A6B2940CDED" modified="2023-02-22" version="1">MNESEDSASSHLISENIYSHAVMEFQRFAGINESGILDEETIQMMNAPRCGNKDLVGHGEEARRRRKRYALQGSKWRRTDLTYRISQYPSKMNLKRSDIDREIARAFHVWAEVTPLNFQVKKEGRVHIDIRFVSGEHGDGDPFDGPGNTLAHAYFPQYGGDAHFDNEEHWTVSSYSGTNIFQVAAHELGHSLGLGHSSVRDSLMAPFYQKYKPKFKLHQDDVLAIQALYGYKDDNEDESSTETSSRRPSEPDPSGDGPDLCQDSGIDAVTRIADGSTYVFKGEYYWRIESSGIADGYPRRISADWDGLAGNLNAALTWADGKTFFFKGNKYWRFKNMRMDKGYPKLINTGFAGIPDNVDAAFVWGGNGKTYFFKGNEYWRFDSKNEPPVSKQYPKSIKNWNGIPTRVDAAFRWENGMTYFFKGPLYYRFNDIDFEIDTRAKPPFPRQTSQWWFDCQSLSRKLKRRPTKKRSSNLSSFTENLRSFFGIGNTKPIASALTNSELSMNESEWRMHGIPETDEIFNDHIKSDSSNSVNMTMENCKLLTTTTIMITIFSLWLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQL0</accession>
    <name>A0A922HQL0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9496973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQL0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9496973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="303" mass="35315" checksum="B13E4D9CAA340495" modified="2023-02-22" version="1">MFNKEVESIAPKYELNVKEYAIFNDVWEEKWSQIKIQIQNMSVSSDKPTTARVANSPKIKFDINKIQLIEQFDGNMMNFPLFWAEFVRMVDQTDLSDEEKFAALKSKLDDNTKRRIIGLGGKSYKVAKKILVDYLLNPNIVKKYYLQNFQKEKKVENSKNIQAFRNLITEATITYENLKLAKVDNTSIEIFGLMLIERMPDSILTRCRIQDDTKKNVETIIDQMRQELLQVEEIEGNSLFWNNNNSITDASSNQEGHSGHCQNNIVATKGETKKDEEEKHVTILSSKSNKKSDKLHRIFRFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQQ7</accession>
    <name>A0A922HQQ7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear localization 4 protein-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Nuclear protein localization protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NPLOC4</name>
        <name evidence="10" type="ORF">DERF_012787</name>
        <name evidence="9" type="ORF">HUG17_8642</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQQ7"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="139"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="504"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7637538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9501984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="536" mass="61420" checksum="3F923B80A64DD665" modified="2023-02-22" version="1">MASTNNSAMWSKLFNLPTSGEIEMVDSILMKHDGLIVRKMDPNLCHHGPKAQCVHCAPIEPYDESYMKKQNIKHMSFHSYLRKLKRGADKGKFICLEDISCKIKPDCKGHPSWPRGICTKCQPSAITLNSQTYRHVDNVTFENTSIVENFLDYWRTTGNQRIGFLYGYYEPHKDVPLGIKAVVVAIYEPPQESTRDLIKIHMERLDFTDVDMMAMQLGYKRIGWIFTDLIPQEKGTVKYIRCSDSYFLTAQECIMAGFFQNCHPNPCSLSKSGYFGSKFVTVCLTGDRNNQVHIEAYQVTNQCMALVRDDCLLPTNVPMLAYVRESNKERYVPDVFYKVNDQYGNEVTKIARPFPIEYLLVDVPVSAPIEQTYTFNPIPGLRPFPIENRMIEGHLQDFQALLQYMRQFRSEDQFFQAMSDFHLLIYLASMETVPLRDALADLLKALKSKDASKAIEWSKRENWSTVEQLFKAHSDDYGKQSTTQSTNVQQHQQQSSSTAAASTSTGQKWSCTYCTFENELQKSSCEMCNLPKGNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRY0</accession>
    <name>A0A922HRY0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LINGO2</name>
        <name evidence="5" type="ORF">DERF_012476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRY0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9501643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="422" mass="48224" checksum="1DFBCC0E29516996" modified="2023-02-22" version="1">MFRLSAVLKLLTQQQQPLNSRTQNFIITQTTDATANDEEALVAEDAAAVAAVSHLIDRHVFHYQEWSSDLNYTKLLKNCSFVDNDLFCDCDLLSRTFICYNVQSVDQIRRAFDHLLNATRSIYWNRLEIHCIEPYSNDDPTTATGSDNSSGGGTTKQSTIPPNKSFHISYELFTDGPRFDSILFVGDCSKPRHYDNLIAVDRDVQQIIMHRNMLRISTSCSLFQPKFERLTELILKDCLVAGDMISSTFSTRCLGHYGTRNEPMQLSKLIISSCNISLIEGGAFYNFAELELIDLSRNQITHLSRQAFAPHLYRLRTLKLHHNKLTSLNGEFFEKLPELREVLLSENRLQTLPFLPSAGPGVAQVLRLAENPWDCRCRLTWILEEPMDSVRLISDEPRCETPINFQNQTLFKGLQLIKQTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS37</accession>
    <name>A0A922HS37_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c oxidase assembly factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COA6</name>
        <name evidence="5" type="ORF">DERF_013875</name>
        <name evidence="4" type="ORF">HUG17_0800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS37"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042775">
        <property type="term" value="P:mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008535">
        <property type="term" value="P:respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042289">
        <property type="entry name" value="COA6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46690:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7645262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9497944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="94" mass="11545" checksum="3E67F9F60B164DA3" modified="2023-02-22" version="1">MSSFPRKENRLKCYASRDQYWHCLDQHSNVKNENNDDQNQNNNIPDECKKLKSLFETDCPQQWVQHFNRKYRYLKFKDKIEKGFEPIDNDDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSG2</accession>
    <name>A0A922HSG2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polymerase delta-interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">POLDIP2</name>
        <name evidence="3" type="ORF">DERF_012577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSG2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1470">
        <property type="entry name" value="ApaG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007474">
        <property type="entry name" value="ApaG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036767">
        <property type="entry name" value="ApaG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003967">
        <property type="entry name" value="PRK05461.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289">
        <property type="entry name" value="F-BOX ONLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14289:SF16">
        <property type="entry name" value="POLYMERASE DELTA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04379">
        <property type="entry name" value="DUF525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110069">
        <property type="entry name" value="ApaG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51087">
        <property type="entry name" value="APAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApaG" evidence="2">
        <location>
            <begin position="205"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="388" mass="45125" checksum="7D2E55A7F68994B7" modified="2023-02-22" version="1">MSFSRYTPWILHSSCRPLLSVSIRNCQNYRLAEIGRIVSPKISNEKYDTGQFFLHRVFGYRGVTLFPWTAKVYDRDHRKKQPSQITHNERNEFKMNGVTPKPHTYYQVLIDQRDCPYVKAQTEAVTFLGNHDNTRALYAIPGLDYVAHDDVIPYMSTESTLIQHQLFEKFLTFEPDKDPPFAPKETLLAWQEKNHPWLELSDVHRETTENIRVTVIPFYMGCRLSQNNNVYWWRYCVRIENLGDITVQLRERHWQIYSIPGILESIRGRGVVGEEPVLSKKFPAFQYSSHVSLQDPSGHMWGIFKMEREDGTMFDCKIPAFALESKHHNDNTTHPNHHHPGPINLNQHKKHPSNASSNNDVTNNDPKHTNSSSSSSSSNNHHQQDDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HST9</accession>
    <name>A0A922HST9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LRRC47_1</name>
        <name evidence="3" type="ORF">DERF_012078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HST9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="223" mass="25054" checksum="C094F43144C289EF" modified="2023-02-22" version="1">MATSKKSNNQQQQNPNERVEWGLLLKQKPREIVLSGDRIAKQIEEENGLNELLFKIKSLNFLEITDASSLTSINTNISNLNNLTNLVLEGNKLSSIPAEIGQLTKLKCLNLSRNEIEILPDKVFENLVHLQSLNLEQNQLKVLPEMSKLSSLISFKCGSNQLKCFPSTLCDKIRKNKELSAQSSIPIYENGAIHLAELDASHNQIEELPYIIERFGCIKIIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HT56</accession>
    <name>A0A922HT56_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LPIN3_2</name>
        <name evidence="2" type="ORF">DERF_009002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HT56"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipin N-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="76" mass="8901" checksum="0901F0FBC4677AE4" modified="2023-02-22" version="1">MIIKDNSFPELCVPQFEKSLESKCKKKKKNSQYCISKSNMYNIEINDEPVEIHMKLGDSGEAYFLEECDDDEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HT80</accession>
    <name>A0A922HT80_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SETD1B</name>
        <name evidence="19" type="ORF">DERF_012012</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12304">
        <property type="entry name" value="RRM_Set1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19169">
        <property type="entry name" value="SET_SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000010">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037841">
        <property type="entry name" value="SET_SETD1A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="257"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="17">
        <location>
            <begin position="1409"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="18">
        <location>
            <begin position="1531"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="63"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="549"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="845"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1164"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="848"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="885"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="943"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="961"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1044"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022603"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
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            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
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            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
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            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9501146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1547" mass="175075" checksum="6BB1C22A3F5D7DE0" modified="2023-02-22" version="1">MNGNIDSLVASMDKLSSSESSPISNQSANDLLIQDETIEKYSTNNNNHKDNIGQDSINDLIKIDPKNRMTTTTTTTNIDSSIGHHPNHNQIIRHHPHNDLNEKNLNHHHHHQQQQQQQQQHRQNDAHHHHPHSTHHQNNQNHKSNVTNHQNQIPSFQIQQHHQQSSQILSQQYPPSSTLPNHPKYKSYKLVSDPALRKGATKLYRYDGTVSSKELAIIVKDPRQHSVSLHWTLREPADLIVPRFKIDKNYVGTPPSIEVSITNLNDNINKSFLIETLKKFDSMEEIEIFYHPKTKKHLGLAKVIFMTPSGARACVTKLNQTSLMGNIINVFFDPFAKKINQIYESIVNPPPANSLSNIDNNFIDPNHLDPNKSRLTKTSDYGSYDVSSEYNSATLSTPSTFENQSFYSSSTNTINTFDTASTPSTVSGWKTNDKKESGNQSPVRESLEKRISNLLRKNCVGMVAPFFPDSGNNHQDPNFSPLPHILNNHEHTFHRRNSQKRIDDSDAILGTPPSPFVSASEYLKWHQVTKEIDNKDSDKNQTNDMNAMSVKKRHSQDGHNDNNVDYNDDDDDDRMSLSSLSSGDNKFEDNSVITNHHHHHHHTTTTASMAGTTMNYNDLSTMMAQWNSSTATAATNAYNPITNSLFPPFMYHSFTAQPAFSFFNSFITTAMPSMPSLDLNDIRSRIARSNEDILKELLDDTLKASIKDLKEILRKDIYKKIVENFSFKMFDQWWEDSERKYHHHSSDHINAVTGGDHENKVGERPLSPFKLAEIHLPFLTNPIFENSIQNRSRHQINSSNLEYGVSRGLRAAMGKLPSFKRKIIKPKSPIDDKLSDISDEDDLDNRRTIRRRPHQRIPHHRRKRSSISSESLPSRHHRRHRSDISESSSASSSSSSESSSSSSGSSSSSSSSSGSESESASSSSSSSESSSGSSDEESEDENGSSASVSGSVSAEEESGSESDASGSSSSSSAVASSLADAASVASSILSKKSQTTKSSTKSSTKSSLAAAALKTGENKAIETKAQVISRDIMDKSVPAKHLDDDDDDDDVYDSDSSRTCSADETKVCEEELRRRESISLNGMNFDDIKNSKTREEFEASEALISLAASWFEQPSGDDFSHLQNQSQQDSKLSMPLSSNDLIQMEHNYCRRMVIERQELSPLLVTSGKRKRQPKTAPVEPKRKRKKKDEIVTDENITPSVLAVASEWRKAKRKSVKQPELVSSENLMVTDENKLFKDEIKSTTPEQPPITFPIRNVKTEETILFEFLHNGLELEEIGYLKRRYHQLLEEDNSNLPWLNDIHWVDHPATCWQPPKKKRKEDNLVRVHETGCARSEGYYKLDRMEKMHHIANIPIASNEMEDTNRPKQIVTTQQLTREARNQRRLYNLVEQQASSYHTDLLKLNQLKFRKKQVKFARSKIHVWGLFAMQPIPPDEMVIEYIGQRIRPMVAEIREKKYLHEGSSYLFKIDSDTIIDATHCGNVARFINHSCNPNCYAKVITVEGQKRIVIYSKQLIEVGQEITYDYKFPIEDDNKIPCLCRSVGCRGFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HT81</accession>
    <name>A0A922HT81_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ssb-c31ap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Ssb-c31a_2</name>
        <name evidence="9" type="ORF">DERF_009049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HT81"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9510527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="92" mass="10558" checksum="8B29C01010F3432D" modified="2023-02-22" version="1">MSSKKKQQKAMAPDSGEESPNSLKLSNNRYLTVSDFKNKVRVDIREYYRNKDGKRKPGKKGISLSMEEWKKIVSNMDMIKKMIKVQGDSGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTF8</accession>
    <name>A0A922HTF8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTF8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="233" mass="26247" checksum="5548E1D83E3B1478" modified="2023-02-22" version="1">MNTPFINDHFHSHLSYNLISPPTPERPRAISQYFNSALTIRTNNYQNSNTHLDHLQKSKLPLIIISTYHCISVVILDGTVTQIHTTHACSNSSVISIYQSDLTIRHHLTHSVIAPYVVEKLFHDSHSLTTHNASHLVHHLTSTPPQTLRDHTPQSFSITIQKPTRPLNIPPGNLTNTTRMEHITVNFDDDKITLPTQSNPRCIITHEIDNCVKSSPTSSLTMLTNNSNQKSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTW4</accession>
    <name>A0A922HTW4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glu-AdT subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">QRSL1</name>
        <name evidence="2" type="ORF">DERF_009373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTW4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="190"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="464" mass="53201" checksum="CFA7926B9B8B6CEE" modified="2023-02-22" version="1">MLKVNLDNSWPLLNRSINEIHHLFRTRQLSPSDLFEACRQRIRDTKMLNSFITCTDDLGLDQSSKSNERYLQGKPFGLLDGIPISIKDNFNTKNIRTTCASKMLENYHPPFNATVVEKLFDSGVTLMGKTNMDEFAMGSACSESYFGSAYHPWNSSLNCKFCLKSENPKTITESKPVDDKNCWFITGGSSGIMARNVNDVRLVFTCLHGHDPRDSTTVAVEIEDCEHLDLNNLTIGIPVEYDVENLSPTISKAWKDAEHMLRDAGLRIERISLPHTGYSLACYSILNSSEVASNFACYDGIEYGYRTSKMDLNLEDLYITTREEALNDIVKSRIIAGNYFLLNQNYQKFFEKSLRIRRLITEDFVRAFQTVDFILTPVCITHTMNYQEWNRMDQTEEAIREDYCTQPANMAGLPAISLPFKLDSDNHHLPIGLQIIGRRFNDYQLLKFSEKFQQLAQFPHLIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU30</accession>
    <name>A0A922HU30_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU30"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="135" mass="15399" checksum="943154CF7C02A6E9" modified="2023-02-22" version="1">MTPVMQCYKCYGYNHKISECQVPDQMCLHCGDFHSFNQCPRKSSPAICLNCIRSNITNATPHNSVNRECPVHIRLLSRSPSSLTSFIDYCNEHHVDIMIVSEPPIKKQLPNFPSSIVPIFHHTNTIRLSEHVCAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU55</accession>
    <name>A0A922HU55_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pseudouridine 5'-phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pseudouridine-5'-monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HDHD1_6</name>
        <name evidence="9" type="ORF">DERF_010807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>psi-UMP + H2O = pseudouridine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10944"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17802"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58380"/>
            <dbReference type="EC" id="3.1.3.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.96" evidence="7"/>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU55"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990738">
        <property type="term" value="F:pseudouridine 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000055">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9506060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="244" mass="27403" checksum="86C69E956C1E74DD" modified="2023-02-22" version="1">MSSSSSISSVTPLQPQKTITHVIFDMDGLILDTETLYEKAINSVTKRYGHEYPFEVKMKTMGRIGPEGSQIIIDELKLPLTVDEYSRLVDEEYRKVFTEFVPLMPGAERLIRHLHNHGIPIAVATSSKAFAFDLKTKHHPELFQLFHHILIASNDAEIVRGKPDPQTFLVCARRFQPPVSESQMSNVLVFEDSVAGIQAANAAGMQSVWVPDPRMPKNSVQSSLVLKSLQEFKPEQFGLPPFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUG0</accession>
    <name>A0A922HUG0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytoglobin-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_011177</name>
        <name evidence="8" type="ORF">HUG17_5949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUG0"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47217">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47217:SF1">
        <property type="entry name" value="GLOBIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7643587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9506444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="155" mass="17887" checksum="C7BA0788B786C49F" modified="2023-02-22" version="1">MTLTEKDTEIIQKTWTMVRADSIQAGVDLFRKFFEANPDYVKLFPFDNHEDIEAVLKSSTLKMHAGRVMTALSSIVDNLNDPIMFEENLQKIIISHVQRNIELKQFENLKLALVQLLMDKLGTNIMDDQAKESWSKAYDVILETYKKSKQNSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUH8</accession>
    <name>A0A922HUH8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GATOR2 complex protein WDR24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">WDR24</name>
        <name evidence="11" type="ORF">DERF_011408</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUH8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16693">
        <property type="entry name" value="mRING-H2-C3H3C2_WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049566">
        <property type="entry name" value="WDR59_RTC1-like_RING_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21720">
        <property type="entry name" value="MIOS_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17120">
        <property type="entry name" value="zf-RING_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="104"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="191"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="WDR59/RTC1-like RING zinc finger" evidence="10">
        <location>
            <begin position="920"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="581"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9506689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="969" mass="109798" checksum="0EDEDD33042457C6" modified="2023-02-22" version="1">MFQDTMQFKTDSPVNAMAVSRDGLLAVAGRSLLKVYNLCDETGSSFGQELFNLRSSNLKNLNFSNSDVTWCSLDNDILATAATNGAVVIWNLQNSTKSKIGVVYNDHKRTVNKVCFHGNDPNLLLSGSQDGCMKLFDLRKKEAVTTFVSNSESVRDVQFSPHWTYHFASVQETGNVEIWDIRKPDRPECNFIAHDGPVLACEWHPNQEAYKWLATGGRDKIIKVWDLSNRNRPQLIYNVHTITPVSKLKWRPEKDFHIGSCSLVVDFSVYVWDIKRPYVPFAIFGTKKDVTTGLAWKNDPFVFISSCKDGTIYQHRFETDAYYPAEHYPPIGIDFNPFGDVAFSTTDFIYRHSQTLQNSNSMNIGSSRSNRMKTFGLNNLSNNILVQSNSATNLNHSLSSSFTQNNYELPPTNASIACDARPTTRHISIGSPSNHHAHQYLIASGHGQPKYLPSQQQQQQQQISSSSSSSSYSTPAYNISVPISYRKTNETILADHFRCMISYMMLFESRKFPTISACLTEEISMKNFIHSARKYLLMDRTFEELCEHNAQVSDSLNRCQIAQTWRMIRYMFSIAGRHPTSSGGVGGTTGNNPSGGSLQNSMQPINDSGDYKMKNEIPSRHASGGGGGTRHFSGNNNAAVNNHPFFSKESKHSDDDDDRNDNNQLDLFQNHFPTLKQDTMPSNKFVVDFFDYQPNQLETMDSIEQRLLHYHHRNDENFYDFESNCQEWELQRESIFHRHNIAEYGIQMNEMNANNAGDNSLMSNYEVNSSISYDEDDELDFNLNESPGFSNVNLQALLSSKNPAPPTWPIYESVAQMLRFYVDVSDVQTAVSIILVLGDRMKQIVSIDKQTIQIWFRSYIDLLHRFQLWNISTRLIQQCSDPDIQAINQSLTSVLVYCALCKKAIHHGSVLCEKCRTQPSTCSICHVSVRGLYVWCQGCAHGGHLKHMLDWFRTNSLCPAGCGHQCEMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVB0</accession>
    <name>A0A922HVB0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CREB-regulated transcription coactivator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CRTC1</name>
        <name evidence="13" type="ORF">DERF_010588</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TORC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVB0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008140">
        <property type="term" value="F:cAMP response element binding protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024786">
        <property type="entry name" value="TORC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024784">
        <property type="entry name" value="TORC_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024783">
        <property type="entry name" value="TORC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13589:SF15">
        <property type="entry name" value="CREB-REGULATED TRANSCRIPTION COACTIVATOR, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12885">
        <property type="entry name" value="TORC_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12884">
        <property type="entry name" value="TORC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transducer of regulated CREB activity N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Transducer of regulated CREB activity middle" evidence="12">
        <location>
            <begin position="278"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="209"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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        </location>
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        </location>
    </feature>
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            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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        </location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007167"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF12884"/>
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            <dbReference type="Pfam" id="PF12885"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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    <sequence length="1039" mass="114438" checksum="54801ED3FC18D9D0" modified="2023-02-22" version="1">MANPRKFSEKIALHNQKQAEETAAFEEIMREVMGATRNRTSSYSNHQQQPLQTAAPPLPQPIQSQNHLHIAPSSFNPANRAGSLPNVNHIEQQQQQQSTDSTANNNNLNNNSNQSSKGTNVTTTTATNTTTATCIDLQSALNNLQEIKNDNNNNCSNNGSTNITRRNTINNSLTGTTGMIANRTTITGGNNNNNNTNIGIGPGHRHHSSHNISSMACGIMTSGSVSPTQTSSSPATGYNDVQQQTMRFMHAHRRSQSPYSMNNNAYLSPPAADTQWRRTNSDSALHQSSNNQHQQETNMTTSPIDVTGGFNQILHHHNQQPHSPTNNSSPQDSCNNSPGQTPGTAISSGSTTMIIDGTTMLYSNSSSDNQQMMNWEYYAHLRPRSCEVPGINIYPSQEDGTMNNINNTNDTNQIHHITISSNTGSLPDLTNLNFPVPLNVPIDGTTDEQQLQQQQQRQHQQNLLKHIANNTVNTNSPYNSNGPDSPYSPTSSHNSNLSPPPPMIQQQSQQRNQSPNRRQQSPGPSPSPTAQRRRAHHNANTMVMGNPRQQAQQQQQQVCYDHQFPVQRHHPITQPLADSHTRRINKDPTQQQQPPPPPPRPPKIKLEGLMMVTNECCGDDNQCIPPLSPYNNQHSSNSSHHHHHHHHPHHHHQQQSNNNNNLNLMNGHPTSPTSLHHQQMNNNNNNNHFQFSNHAASTPITMTCPNMATMGAHRSTTPSDSCSAPTSPASQNISPSNSPELTLNNATGAGGGGGGGGCVGNQPNGLSNTTTSTNQHFNQSYSSPSYQNQQQANLLQHQLEQFRMTNDAEPGGYVMTCTADMITQQQQQQQQQQQQQQQQANNGQNSNVFYLDSITLNQFNDNTSTIVMASSSQSSPHHQSQQQQQQFNQTSTPLHDPHQQQGSPFGQNDGLFFDSSQTLTLNTMSTEPFLKTDGLSSLYQQHQTQNNNGQHQPLSNSSHCTTPQTPSSIPDIILTGPNNLDEALQTSNDLIKDLNNMSSFDTDIFGCHNDDVIRGTVGSFDSFDLDSLQMLHDIETNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVC9</accession>
    <name>A0A922HVC9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009625</name>
        <name evidence="2" type="ORF">HUG17_7477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
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        <property type="protein sequence ID" value="KAH9511154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVC9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7637271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="206" mass="24043" checksum="AEC0EF62D41AF02B" modified="2023-02-22" version="1">MSLELNTLDHLFKIQKIIDNDKLIDPRLSSYYRWLFNNQCDQYESCLAIHPESSKTEPNNNNNNKELANLPELCPNCWSSMARFRLIPKKTKHKKRMKKGNNFNHNIMNAKCKNCESKFKFKALSRSQQQNIQESKKIINRTNITPSKSSISVNSKTQKKVINQSTPTTSQNSKEMLQKFLINSKKKRNLDGHTKLSTFLQQCFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVN1</accession>
    <name>A0A922HVN1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVN1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9507132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7451" checksum="FA4C38D639A9E91D" modified="2023-02-22" version="1">MFVSEFANVSNVERYANLNNQNKPEKHQALPFPSRPKKKEFVHFINGHMFMFCFLHILRLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWG0</accession>
    <name>A0A922HWG0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_009212</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWG0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="91"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9510703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="233" mass="27661" checksum="5B74630E08CE4E0A" modified="2023-02-22" version="1">MAEPKGWAKCPEIGDLVADNFVPFKVPFGPSFTPEYVIRKFRQNNLNVGLWIDLTNTRRYYRSDLVKNQNIRYEKIFVTGHGECPSNDQIKRFIQICSNFLRMHPDQEIAVHCTHGFNRTGFMICAYMVRELGWSISQAIDHFSERRHPGIYRQEYIDELLRMFSNDDDDPRTITAPAKPDWSRDNNRRSYNHYHRRTSSSDPDNLIGRMNNLRISQQPVIDNNYNYYYDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWX9</accession>
    <name>A0A922HWX9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NDUFB11</name>
        <name evidence="18" type="ORF">DERF_009705</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWX9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13327:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13327">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ESSS SUBUNIT, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9511233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="195" mass="22891" checksum="09F8FC23419217BE" modified="2023-02-22" version="1">MMLRSISRFVLVNQRHANLALKRSVHQNHVMNTLVKRLGDFKWSSSSSSSSLMMITRGIKTTSKKDETYVEVFDPEYINEKKPKGPETAEEFADVSSQKNWISFGYDEVDQKEDRHLANAYFFSYFTLGCLVFSWIIYYYPYIDGYDWAQREAFIEVNRREQLGLPFIDPNLVDPEKITLPSEEELKKLNLEIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXI1</accession>
    <name>A0A922HXI1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">40S ribosomal protein S18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RpS18</name>
        <name evidence="11" type="ORF">DERF_009227</name>
        <name evidence="10" type="ORF">HUG17_7179</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXI1"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7636973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9510717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="153" mass="17923" checksum="5E151FA655A1A7D1" modified="2023-02-22" version="1">MSLIIPERFQHILRVMNTNIDGNRKVMFALTSIKGIGRRFSNIVCKKADVDLNKRAGELSEEEVERLITIISNPRQFKIPNWFLNRQKDIRDGKYSQVTSNNLDTKLREDLERLKKIRAHRGLRHYWGLRVRGQHTKTTGRRGRTVGVSKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXM5</accession>
    <name>A0A922HXM5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_011677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXM5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF158">
        <property type="entry name" value="V-SET AND IMMUNOGLOBULIN DOMAIN-CONTAINING PROTEIN 10-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="393"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="523"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="760"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="903"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="903"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9506972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1011" mass="114566" checksum="6FE08177FB9FF140" modified="2023-02-22" version="1">MIFVVVVGHYLLVNSTFFFSILPIELHPIIDDTQARHIFINDTFTLRCFVHIDIGVIIVVDWDHPNNNHQQRHSERIFKSAAETTRQLVNNNSYDTVAINITIVNATKEDEGLYRCNATDGNGRTFSATKRIVIFDEHLVSSINFTTDFHTPIIGEYGHDIHFTINAQAFPDISFIDLSWYKDGNELSSINTNNSHIQMNLMNLFNDNQTQITLYMISARPSDSGLYTLVGQTSWSSQQQRRNESMTNISIPVYIQGDIEILIENHQDFYRLNHSYELLCKSYGYPSPSIQWQWHPCETVYSCLNDDGDDDDQITKITWFNITTSSSSSSSTTTTISDNDARIIEIDDGNETTKVSYLNMARLSLKARQSGVYRCFSSLRHMNDTIMKHQEIPFIVMDAEDLFEIRPSTDEPTVNDTIILTCKASVYRYSQLWWVNTRLDTDIINPINVNTMLEQKNQSTSDPLIESMNLSNDQNEYSLSSTLTLSSVTLNHSSLFTCEAVLLFDALKTERKEFFLNVKEITPPIIIETNMNESIIEAEYNSQTELRCYIEGRPRPQLEWYRNDQPLLMDHHDSGVRLYDKGQRIVFTRLLAKDSGLYVCRGRNRGGEVTCAVLLKVIGNMDQTSIDLLPYCCLFNNGCHHNYNGLFDCVLYQNVDILTPHTPDSPSNKERFDYFIANNGNGSAAMAGISYVDLLNRQMANTSSSNGGVDYINTAITNPIITTTNINGIVNVSSTGVAYYNNNYGSPGICNKNFSVVGNGQSKRPSSSSSSNRFQRQWSSISQRRQGRTVTTSDLICWAFQCSRGMDYLTMRKILGTSDYLKMSSNNSNGNGVGCEQSIMVNNEDNPITTITTTMIDECEYETNISQLIMDNNRNHQHQHNQQHSGSNEKTSIIMANQNSNNNVVIEDNNKPSSSSSSSIIKMNNNNNNNDDDDHVGCDDDGDNIIEMSILERSLTETSSNHHDDIMMMNITAKHNGHHHHHHFNNKDVRMTTTTTTTTTKNLIYDNLTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HY23</accession>
    <name>A0A922HY23_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Netrin receptor unc5c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">UNC5C</name>
        <name evidence="11" type="ORF">DERF_007380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000002">
        <property type="entry name" value="Unc-5 netrin receptor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057755">
        <property type="entry name" value="UNC5A-D-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25609">
        <property type="entry name" value="Unc5_NetrinR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="10">
        <location>
            <begin position="243"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="768"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="884"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1300"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="769"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="835"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1300"/>
            <end position="1327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9516651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1552" mass="175023" checksum="5810002AC0BEA7DD" modified="2023-02-22" version="1">MIKHTVVTTFMNDTYANLTLTTSAILNLTSLHNPHVNLHSHNHHHHHHHHHQLNHQHSNHNLSITNSSSTTTIKAIIEDDESSLPLLPLESSHPSLGIGSSTSSSSSSSTSSFDHTIHPDKNNPKGLRFEEEPADSYIVRSKSAILRCRTLNALNAWFTCNSGDERRIQSNQKISNYVDPQTGIRLIEIDLEITRSDVEEHTNSGYTNPYQCWCTAYGGHHQIMSRKASVSFAYLKKHFHLEPKSVRIALDDGKSSIQFRCQPPFGIPKPIVFWMRNDMIILESEPEHSSSSQSLSSSPSSSSSLKSSQKSQFLTEKFIRRKKNFPDKKVIRKKFISNNKTITNYSGNGGHRKRMAESVNNNYNDNYDEDEDDEMDDEDDDDDDDDDELEFDASKQPEKEIGSDDNDEDSILPHHFDLAAGHVSNSNNNNIPINYHMADDYSLVIKHVTMDDHANYTCGVYNVAGVRFTRPATLTVFVNGEWSNWGSWSPCQLAPGLTAQGLKCGIGTQKRVRHCSNPTPVNNGQFCPGESVQVTECTILCPPIDGFWSPWSQWSICSHECTQVRRRICNNPIPEYGGHDCFGSDFLIKNCTGGLCRKNFDPTNFIQPIGSPTTTLQQSNDQIYFIIIFILILIILTFVIYIVLKFQLHRRRHGAKSTASPFNHHSWLNGGTDSDHLSHGSLGPIDPEDSLVPQTSLTPTLLLLQQQDGRFYNKAVKPSGNYNHYPMEPILSKQQQSASATPQKMMLVSRLNQSNQQNGMLDHFLMQPGSGSSLQSTPLHPKGHPLPTIPRDDDSVSFRSGGSSANRYEEPQFHHSLVQPISGVRKSVKKGSPHSSNGGNAGTNSSSGSANTALTTTANDMSQNESEPDYAEPIINEFEQTANIRPPSLTTAPPISPSPQKNLRYSSEESSGCSDGSNNIGSLCGRHEKFLKINHELTRYGHYSSLPNLGVCLYLPPEFLILTSSMSGNHSMNRATDESNGDLYIRYGIDTRARYPGLCSLSSVITLNLSKQHQHYIDLNRPAILSFRHCLSFPNHQQPIDMASRKNLVIMWQNQQEHQHSSKSSSKWIELIRLDDQQDPNCYAYLDSNHVYLVTRLLGRFMFCYKHDFSQYGSTSTTADSNLELPSTFGSIGRSASKSAESSVISKMVNFSITIEQCSQTEHLIKCFVYDNLPASVLMFQNDQLPSLNSSSESTVMNGQNKLVQVLIGRMSNPLLTTAYNSSTKISLPPNRSSALCFELIQQANSTPSHSRIPNIGSNPRMEIPLEHLCSLGPNSMLHCSFMVPNVRNTNILIMDNDENLVDDNDDDQEQDSDDDIDLQDSYDSVDDSSFSPTYENKPTRPYSRRKKSLLKKNYRNLNYEIKVWQQKPETRKRLHHHHSNTLTLNYLNMRPLHRLPSSDSAQQYFYHEESCRLFGDSELELRRSMAERLDLSLYGNDLSPWKEWAMAMLMISRDNSHHGWLTYFERQPSPSIQLMELWESKTITELMIAMVDDKIGRRSHRKRNNNKQSSILMSTNPMKMKELFFSKLLHQIQTTIGGSSDLVDLILGHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYL4</accession>
    <name>A0A922HYL4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">METTL6_2</name>
        <name evidence="6" type="ORF">DERF_007774</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYL4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9517074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="300" mass="35504" checksum="78FD5014C53EE27A" modified="2023-02-22" version="1">MEQSSESSSMKKMEDDKKFGQSARQLTKEEIDKLNSDTELISDFRQRKLEQECKKNWDLFYKRNEDRFFRDRNWTTREFHELLELSAETNDDRQLRLLEVGCGVGNFIWPLLESGLPFQFYACDFSPRAIDLLRKNERYDPKRCHVFQADITEPNGIGRNLSSSSSCDNENLKFDFVALIFVLSSIHPCKMPLALKNISDVLDDDRGILIFRDYGLYDHSMLRYSNGHKLDENFYVRQDGTRTYYFSIDVMNKLAQESDLEVIQLNYIQRETINIKENLCVPRIFLQGKFRKKRKSSYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ67</accession>
    <name>A0A922HZ67_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ67"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21219">
        <property type="entry name" value="FI19613P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21219:SF4">
        <property type="entry name" value="PID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="17"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="793" mass="86626" checksum="46143770F4738625" modified="2023-02-22" version="1">MAKSVNGGGDDTDNETTPICRCRVLYLGSAVPHITKDGLQGIQEPLRDLYPEQGVFWNTDRDHIATGIDSWLSVWSNGILVENVDDKGNTIRRFHPIESLHYCAAVRYVSVPANDTTSTKNGSSHDSNKIAKFLPLDSPFSKNSAIDPMKMGHPPLFACILRRTSGIKVLECHAFICKKEAAANALVRCCFHAYADTMHAKQIELESPYEQLDRRRSRSIGSALDSQSLIDDKINTWQKNSAGSSTGSPDETNGFGETRSISRQKQQQRTPSVASLVSHSMAAEHHHHHHHHPQLPPPPLPPHLHHGLPMMGLPEPIYGIPPTGTLRSVRSFISLAALKSHKKSRSRQIPLPFAHGLPPPPLPPQPQPVMFATLSKKELKKVLKKESTLKRKHKYKDFPLPFVTANGYPAPPPPPPQFIYGPPPPLPPHGIHPGPMPIYAPPMGPSYYGTIDSRKSRIPSLPPPPPPPPTSNMINENGHMLPPPPPPPPSSHFDEPIYMPAVPSPNGTLRPVTPHGEPIYFEGRTVNGLPPMPMPIHHHPGPPGPMFMGPTHPQMVPCTLIPTLSRKELKELEKQKALMKKAAKKEKKNAKKNKNQQPPHPQQQQIMTNGNEIGDPDESIISPSEMQLSSGNYSNASTGGGGGGGGIYKKKGHLNERAFSYSIRQEHRSRSNSLSNLAFENGPNNGSGRNGENESHNNSSVSLKSQTDAMAAGQPVPNGPKMMNGNGSIPHHNGGPMMMMDANGPIDPNTLATRMSNLSLKNGYGPNNPPPPPPPLPTNGYHYQQRTATIKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZN5</accession>
    <name>A0A922HZN5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_007085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZN5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560">
        <property type="entry name" value="CYPHER, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46560:SF9">
        <property type="entry name" value="ZP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="153"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9516337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="696" mass="79207" checksum="4271DE72C6FA1D69" modified="2023-02-22" version="1">MMMKPKHCDSITTAVDYGYNNFNEKSRTTTSIYIDYWSRIFILIHQYYSLIKRLLLYYYHHPHQKQRPQLSSCKNRQQCHSNFFQSSLLSMIISLLIIFSSSSQLNSQVLAQNKLNNNGEKVSLSAQQNISSPSSTTTTTFGSYIFDPHVQAQCERNLMNIMVTFDQSFNGIVHVRNFRRNPCQIYGNGSTIVVLNIDLLAPSNRPNFCGVHRVKGTEERSISLVVRLHRALELSDDKHFVITCGNTEFSNRNKNEKLMFKFVDRHGHKINKLYHGEPYRLRAEIVQQHQQQQISSQLKTSGSQSSYHLYVRNCFIFNGNDTDVEFLDNNGCPNINDHMLGPFKQIGQNIAEAEIYSMFKLPGTNQLHMQCLVELVDNCSFCDPSFCPLIGNETMMMNKTIENNHNITSIGNSRNRPTSGMQMLASTTVYVFEPDQQMSSSIMMAGVGGGGSGGSDDFIHGHCNEWRFPWLIALCIMLGILLIIMMVVNIFLCTSMSCSCFRSEMVEHEPTIMDDYDPYKIDIGSYYSPYDSRLSLNRSTTSIANPMTSNVVGNHHHHQHNTHHHSNNHHGNNNGDRSGSYYSTQQQPLHLNTIHHHLHHGFNNNNKPIPSMSSSYSPSTTENTTHSRPGAKLINSNKNMGNGNKNRISKPNKSRQQKPSNHKSPSLMTTSIIPLNSSTYNPYQHSPQSIRSDDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I059</accession>
    <name>A0A922I059_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I059"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7699" checksum="6A859E09B41C42C1" modified="2023-02-22" version="1">MIFDISKRIVVNNDPVDEFSPLIGLLCVKSFHENNFFSYTNKDNKCRCNNIQLVLFLHQIPPIVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0Y4</accession>
    <name>A0A922I0Y4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0Y4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="170" mass="20212" checksum="8DE49BDE91B7DF57" modified="2023-02-22" version="1">MTIVGTLCFDVKICIDNHWAAIDNIQSTESHNVDADVWQNSQNQQQIFAFGFPSKICQMLCGLCCYFYQNQQNEMQLRQSQHNHLMILKYDYIREKRRQDFVASMIMNKLDNHSGHYLMVNGTYRLILLKNRRQSKGHMNRQYNWEKLERFVHRIDTCDSEGRINDTIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I151</accession>
    <name>A0A922I151_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retinol dehydrogenase 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_006911</name>
        <name evidence="3" type="ORF">HUG17_1443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I151"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324695" evidence="2">
        <location>
            <begin position="17"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7645905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9516151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="333" mass="38215" checksum="E448333D6054E816" modified="2023-02-22" version="1">MFLFASFILFIVVCVAVKLYFRMTNGICVENTELNGKVIVITGGNTGIGSEYVLDMARRNCAHIVMACRNIEKGKQCARWVYKKIQAENMTTTVITVEHCDLSSFDSVVRFCDRLKRLSIKQRIDYLICFAAATGIPIEQKFTADGLEMHFQCNYLSHFLLIHLLLPLLNEGARIILTSSQAHLFGKIDLENINRLERYDRHPFRTYGDSKLALVILARELSKRLAANNILAYSFHPGTVLTNGIKHNRIWYLRILLTIVAYFYGKSHRDGAQTMIYLTVTEQRWLSNGRYYADCAVAHYNPMVDDEKLADQLWSHSYNLIEKYIDGISIAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2B0</accession>
    <name>A0A922I2B0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2B0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="28" mass="2898" checksum="07382D32DD97E73A" modified="2023-02-22" version="1">MSATRGGSGGFIQSFIANTVSINIQLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2H5</accession>
    <name>A0A922I2H5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone cofactor-dependent protein refolding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TOR1A</name>
        <name evidence="3" type="ORF">DERF_008103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2H5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="360" mass="41162" checksum="1D5E068D6516FE3B" modified="2023-02-22" version="1">MPSPDDKQLMLVVYDPTRNQRRKKKISFMYIIQIIALISIWATILALDPFTITGSIIASGVGYYYKDKLTCMVKECCHDHTSDKWIANRMEWSDLSEEIFGQHIAVNVVSKLVHFHMKNENPSKPLVLSFHGFTGVGKNHLSDMLAKRIYRQFNATGASNFVHKYVATNLAKGNDLSMLAKDIHKKLDNCDRSLVIIDEIDKLPEKYLDILLPFLEHASPYKKSIFIFLGNSAGSNINNKVVQLMHSGKSREDIDYEDLENIVTNNAIKMGGLKNSELITRGVVDLFVPFLPLAKRHVRQCVVDNLRRQHKFSDPFIDPGSEFIRKVMNSIEFKDDEFSVYGCRRVSSKIAIFLPRKNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4H8</accession>
    <name>A0A922I4H8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005667</name>
        <name evidence="1" type="ORF">HUG17_3375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4H8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7639342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="226" mass="25663" checksum="34061890F15CF3B2" modified="2023-02-22" version="1">MTTRSMTTAQKYKLTNPYYGGYRCRISSDCNDDDNNDEIGDRVDQLAYIILQSSRTINRLSSIHGERIIDRFICQPPAVEKRIRKVSYPNPVTNLINSNETCSAIFQANHMNPNQQDQQQQKQKHPASVITLENASKFDITKNHRTNANDNVDNDNILFIRNENCIQQQQEPNEKKLTRSLVNMSSISICSNGVGSGGQSSSSIISGHRRRLQIDLDTTTFFTFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4U7</accession>
    <name>A0A922I4U7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4U7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="103" mass="11594" checksum="284C524A69454170" modified="2023-02-22" version="1">MADDDNHQSSDSSSSSSSLLSLKEQQEKSESTVEMMMIEMTKEQSPLSTISSSSSSSLPYEHDDNESNNLELNLMNLQLKSKQNDSNNDNESLIDPKWNNKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4X9</accession>
    <name>A0A922I4X9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4X9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9518056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="47" mass="5023" checksum="055BE845D516EB3B" modified="2023-02-22" version="1">MSASTIKAAAATTRNTSIVDNNQDCRTTTTTTTTTTTTTKTMTKTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I590</accession>
    <name>A0A922I590_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I590"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="40" mass="4714" checksum="09737B70FB5FDAA7" modified="2023-02-22" version="1">MVIDEDAGYDNENLILHFSYQVNIFLEHHALYDMICVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5L6</accession>
    <name>A0A922I5L6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Muscle-specific protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MP20</name>
        <name evidence="8" type="ORF">DERF_004219</name>
        <name evidence="7" type="ORF">HUG17_0383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5L6"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21207">
        <property type="entry name" value="CH_dMP20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001997">
        <property type="entry name" value="Calponin/LIMCH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF24">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00889">
        <property type="entry name" value="CALPONIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7644845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9520514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="186" mass="20609" checksum="B0629E3602E750C1" modified="2023-02-22" version="1">MASRGPSYGLSAQVANKIAGKRDPQLEAEVLGWIEAVLGERLPSGPFEEVLRDGTILCRLMNKLKPGAIPKINTSGGQFKMMENINKFQKAIKEYGVPDIDCFQTVDLYERRNIPQVTQCIMALGRTCYLHPEWPGPFLGPKPADENKRNFTEEQLRAGEGVINLQYGTNKGANASGLNFGNTRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7L7</accession>
    <name>A0A922I7L7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7L7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036765698" evidence="1">
        <location>
            <begin position="27"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="121" mass="13788" checksum="75D6E31612C6F552" modified="2023-02-22" version="1">MKMIKLLFIVMIIILIIIIDCHSVIASSNVSSSSYNSDEKSNKSNVIPYTSFTNNMTTVMKSNKSEYHSHTISINDDDDDDGVSEEFFSPKAQGFWGWISDCIVKGWNWLIDKVKKLINKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7T6</accession>
    <name>A0A922I7T6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellular heat acclimation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lin-53</name>
        <name evidence="7" type="ORF">DERF_001025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7T6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="6">
        <location>
            <begin position="423"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="708"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9526972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="859" mass="100299" checksum="16916B9C411459D2" modified="2023-02-22" version="1">MDHLPNQNLVDRVNGLIVKHSLAVPRLVSSRYINYQFWATIFTRLFRVKCDLSLRTNRERLEMIRSCLNTLELLAGISLDHIKPLRLLNYDVATISNMLEIAEVWGEHMNDDFQNFVDDSDWLDCELKTTTTKMKNSNLNIQQSLSKSEPLMVNQICDSTKANNLADLLYKALKNQIIALEIEKKIKSYLGDVSVKNQRNIKNELIRASRQSIVRTRTIQPMATFDFNFTREEKRNPILSVDLERLYPEISTEQLKKIQHLEQNLLVLQRGNLKVGQLNRAHLNQILSYTIEKQRRLIEMTNNFDDYGDGKSRFPNKQRLQLSIGQTISQRELRSQKASLSEEIRKFSKSSKAAYLNARSYLERILVEEFRKVDSHQRDHLNEIRRYLRDNQDNMELDKMSVSTFFTIFMYDQPMHEDRVTSDEYKQWKKNVPFMYDFMMTRILEYPSQTIQWLNDGIEKIDDDPYESILQRILFGTNTGAFNEDNYLIVASIALPGYREPPKIDLYNMPEDAFGTFIHYNDQLEADFKLYHNGPVQCARSMYGKENIIATRNHNDLFIYDIKDCLVDYDTAGMFDELFFSANLNNDFFLIRNNNNNNLGTTSPILSYPNLNSETNLEWNHETSGLLLTGYDRNQVAVWDLNSQKKRKTLTTKLILSCDDDGNDHVGFIYDASWHQKHPDICGASTLKGNILLWDIRSNNVKRPSHYFNGHKGSAFQIKFNPFSEYVFITSGSDCQIAAWDLRNMNEKLHSIQLKQEKFHTLKWSPHCETLFGALTNDRKVYLFDMDKIFDSLLPQEIDNGPSTLTFIHGGHTSRVYDFDWNHNDDDPLMICSVSDDNVFQIWQMSNKFVTKDTARLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7Z8</accession>
    <name>A0A922I7Z8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein C-ets-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ETS1_1</name>
        <name evidence="7" type="ORF">DERF_001121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ETS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7Z8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:001050">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000014">
        <property type="entry name" value="Protein c-ets-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF289">
        <property type="entry name" value="ETS-LIKE PROTEIN POINTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="6">
        <location>
            <begin position="106"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="5">
        <location>
            <begin position="659"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9527077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="767" mass="86189" checksum="5805054454E1ECF7" modified="2023-02-22" version="1">MANGGQSMSSLRQPPPLPPQIPLTATAAAYNLTYALLSQQQLQQSTSSLRSDRFDNCLLLIPPPPPPPPPLPSSSSSSSLDATNLPIQVPPLTPGTNQKMSQALAASFASWEKERDEFNIPKDPQLWSESDVNHWLLWAIKEFNLDGFDAQSFLMTGKMICEMGKEMFLAQTPPYVGDILWEHLDRLLRDSDGSIVDNNNNLMIFFNNNNINYKRQQQQHTPPPITSPSSSSSTTNIDPIVIGHHNHSHHHHHNHHHDNLQHLNHHQSDVIYSSPFNDHHHSQQQQQQQSSSSSSSSSSSTSITNNQQQQQQQNTDIISSCTDNVTTTTATATTTTTNSTINTINNNNNNNNPNNNHNKSMIMNVPMTSSMPDVISSSSSSSSSLSTTPMAITTLSNFIDGSYSQSIASMNELSPTGNNNNNADKMIAMNRHQQSNHHHNNNNNHHHHHHHQSFETENAETYQQHLPTSTNGHHHNHNHHNNNNDNHHHYLEAHSEFYLAHTMVIDSGKFSQQYQPKFNRGPHNYFGRYTGNELPSMIDNYGQYENSFSTMTPSSIPHTPSPEQWPTNDLANIGSTIGSTLMPNTIPSPNINTLVPNHMNANYESLPIHGRDQIGLNTMVNNNIIHSNGVHQGANIFHQSSIDGKPFIQAAVLAGSGPIQLWQFLLELLTDKDCQSFISWTGDGWEFKLTDPDEVARRWGIRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGCKPEDLHSVVDLKPEKKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I962</accession>
    <name>A0A922I962_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nitric oxide synthase-interacting protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_001282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NOSIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I962"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16661">
        <property type="entry name" value="RING-Ubox1_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16662">
        <property type="entry name" value="RING-Ubox2_NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016818">
        <property type="entry name" value="NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031790">
        <property type="entry name" value="Znf-NOSIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063">
        <property type="entry name" value="ENOS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13063:SF10">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15906">
        <property type="entry name" value="zf-NOSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023577">
        <property type="entry name" value="ENOS_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitric oxide synthase-interacting protein zinc-finger" evidence="6">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR023577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9527251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="287" mass="32611" checksum="58BD02AEAF631DD3" modified="2023-02-22" version="1">MTRHAKNNTASSVYSYHERQRDNQSSGYGTQHKRLNKDSVKDFNACNLSLQPCRNPVLTPDGYLYDKEAILEYIIRQKAKIMRNIKRYEKEKQKDEQRLKESMEKDDEIKTKKFSDHETMKVLSGNNDDEQQQASTSSSISNMNNGNDKQLPSFWIPNLTPSTEDRTKKPDTIVRCPMSGKALKSNRLIEVKFTPVDPKCINPYRATYKCAVSGDILTNASRCVVLKTSGSVVTEECLEKIIKKDMIDPINDKPLKESDIIPLQRGGTGYSSANELEAKLHRPVMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I966</accession>
    <name>A0A922I966_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_001284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I966"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9527254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="10125" checksum="A242F619CB56555E" modified="2023-02-22" version="1">MLFPVRCWTCGKVIGHLWNEYNERLQIAKVSNDNLENGLEPLFKELGLKRFCCHTMFLSHYETYEDAIKMGFPEDYNEYGDVQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9L1</accession>
    <name>A0A922I9L1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IDH3A</name>
        <name evidence="14" type="ORF">DERF_000787</name>
        <name evidence="13" type="ORF">HUG17_8526</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7641057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9L1"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="12">
        <location>
            <begin position="33"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7641057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9526723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="361" mass="40022" checksum="BA96107363747AAF" modified="2023-02-22" version="1">MQRQFRPILAQFFRAQSLSSHQQNVNRHQSIHTVTMIPGDGIGPEISESVEKIFAAAKVPIEWDRVDVTPVKGPDGRFSIPLKAIESVQRNKIGLKGPLATPIGKGHRSLNLEIRKVFSLYANVRPCRSLEGYKTLYDNVDIVTIRENTEGEYSGIEHEIVPGVVQSIKLITEPASRRVAEYAFEYAIANGRKVITAVHKANIMRMSDGLFLQCCRETAEKHPEIKYKEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGKEGAVFESVHGTAPDIAGQDKANPTALLLSSIMMLRYMEMNEFADKIEHACYDVIREGKHRTADLGGKAKCSEFTNEICARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAL0</accession>
    <name>A0A922IAL0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor 3B subunit 5</fullName>
            <shortName evidence="2">SF3b5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SF3B5</name>
        <name evidence="3" type="ORF">DERF_000636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAL0"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="9924" checksum="DEF21DA3641AF9D7" modified="2023-02-22" version="1">MTDRYNIHSQLEHLQSKYIGTGHADTSKFEWMVNQHRDTYASYLGHPDMLSFFSIAENESIGRIKFNMMEKMLQPCGINPEKPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAQ2</accession>
    <name>A0A922IAQ2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SET and MYND domain-containing protein 4-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_000691</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAQ2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="271"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="10">
        <location>
            <begin position="320"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9526620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="897" mass="105978" checksum="D69966BC684F3236" modified="2023-02-22" version="1">MNSKLRHQIQSRLNDLVVDGNGETKMKMDKMNFTDIEWLINFIEANVTSYGNLWKKIQMHIERKFHNNSKSLLAKNSRISKANLCEIRFYLSEQKKKTHDNCCNLDEEIEDNNDDDHHHHHQSANNHSISDKILKLVNEALRSCHFDDRKLMARLFFIRAKQLALFSDDGNDEESLKQALINIDFALRFRLSKTYLSAKVYLLAKIGNMEKALQLFSILVRNYPMIENKNQFKRFLRTKSHNYYDDNLHQDLIETFTNDDDKYFSSYDDNIDIDLRCSLTNRHGQGRFFMANETMENDELIFRERPFSIAMFPEASLIRCQQCFRLISNTFYPCLNCTEIVYCSTECLQHSYDSHHRFECRMKQFWTERSKSSYHMFHLLNRFGIKNILKLNSSEKSSSAIIEMYINNNQPMDDDKMYKFQIFMNLIDNHEKHGLDFLAYHLTNALDVAITASIVQGYYCDQSRPPPREQIIHLIDVCIRGIRRISINSFEWPNVGTCVCLIGSLFNHRCESNSEWKFMDNGYFHLTTNRPIAQFEEISINYGCGWPLVSFTQRLKQHSCYFFQCNCCQCMEDSKTILALQCRQCTIGPVLLSSIVYNPNDQDCDAICMLCYRPYPNTKQVFDRLCYVRNEISLVMVIFPCLTSKMRSTYLMKIQSYMDELIAIMYDKSRLLMDDLQKSCQILLEYGDGSLMINSKLIKYAQIIDKILPRYDQELVKIKSLDSLWKSMRNLDGITRYLLRKNKIDDEDNNNDDDQKNNNHDDEEVDDYWPSLDDEIRYMSFWTNFFRNYIHHQNQNPNHDPPQYSMITMMELCENFHNRLFGLLKFRIRLLLSSSGGHNDDGEKQHQHQQQKQPQSSSMKEAIELLSILLKSKQDQWNLLQKKMNPSLLPSLPRIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB58</accession>
    <name>A0A922IB58_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_000903</name>
        <name evidence="4" type="ORF">HUG17_4171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB58"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF264">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER ON CHROMOSOME X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276984" evidence="3">
        <location>
            <begin position="24"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7641127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9526845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="380" mass="43719" checksum="B28F908D90FDBA92" modified="2023-02-22" version="1">MNIFAPLLSALAVLSHQSSDVKGFEIVINPVFITANRLQFYAVVLPYLLREHQRKVAPYQNNIRILNENDPDIRGNLEGKVAIITGGSRGLGVEVVRSFLRKGARVITTASSNDPRKIESRYKSITKGIPVGKWNLEIWHLDLMSMNSVIRFLDRFKSQNDTRLNYFIGNAGVMFPPFKLSEDGFESQFSINYLGHVLMSYYLLPYLYRTAKDERDQSRLVLVTSCLHHIPTRIRFNDLQSLQVYSPHYAYGLSKLSVLMFIYSLNRTLSIKQDWNERVKVFAVHPGLVDTDLLNTIEIMKQYPSLANQLTFRDTKAGAETIIYASLSSQLKQKGGEYFEDSKATRSSMLSYNLDVQSRLWMVTRNLLEKWTNGYWFEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBF5</accession>
    <name>A0A922IBF5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Polycystic kidney disease 2-like 1 protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="24">TRP-like ion channel Pkd2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">PKD2</name>
        <name evidence="24" type="ORF">DERF_002346</name>
        <name evidence="23" type="ORF">HUG17_10300</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">JKM2019</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBF5"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000055">
        <property type="entry name" value="Polycystic kidney disease 2-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF183">
        <property type="entry name" value="AT14535P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 18" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="614"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH7636330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAH9528394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="714" mass="83551" checksum="54CC8496275363D5" modified="2023-02-22" version="1">MIHSATSDRQFDAESSSVASSSDGMINKKTKWQTIQGNLEDFWITKQILPKDADKTKVVKTTLRELLTYIAFLVTITYITFSMMNPTMYYQTKIMSNLFLDQPDSKGITFRMATQMDHFWDFVEGPLIHGLYWDKWYNNETASSFKSILYENYLLGAPRMRQIRVRNDSCEIHKDFQRAIFSCYNHYSKIYEDRDDIHEKHIPEFEWQEIRSFAKNDVWGQLSTYSGEGGYIVNLSLNKTIAIKTIEKLKEFLWIDRGTRAVLIDFTTYNPNINLYVVTKLIAEFPATGGMFTSWQFRTLNLLENSSQAQIGLYVCFIMFLIFIVYYTIEEFFEITALGFIPYLRSSGWNYLDLFIILISLALVFFLVCRKYIITKIFDEAYTEELAEHGYMVEMGNRTVSLQIDTYQFDTLGFWSAQFSNILAVLSFVSWIKIFKYISFNKTMSQLSSTLSRCAKDIAGFGLMFFIVFFAFAQLGYLLFGTQVKDYSSFGRAVFTLLRLILGDFDFQAIENANRVLGPIFFLSYIFFVFFVLMNMFLAIINDTYAEVKSELKDDEEFAMMDYFKAISNQILHKLGTQKEQIEEIQQAIKQSGFDGSRRVSFSTIRQELKKRNLSDQEIEMLFAKYDIDQNRELDETELHAMFEDLEGKKKSIEKEMEENKNKRRDSVLSLHGRHLPQFDFGKISKRVDRMEYVLATISNKMDSLFANRIENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBJ1</accession>
    <name>A0A922IBJ1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBJ1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7679" checksum="377840E9012945E3" modified="2023-02-22" version="1" fragment="single">MAKFFFIPQKKVPETCSRPGQQQQQQQQKTPRGQVCINENDKDDDGKNRIVLKKRSTVAVAAAAKCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC38</accession>
    <name>A0A922IC38_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET and MYND domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SMYD3</name>
        <name evidence="3" type="ORF">DERF_001362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC38"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="643" mass="75796" checksum="613F1C6D1A57CB8D" modified="2023-02-22" version="1">MFRYSFSSISTDRSTIYDYDDDHKRLSKSVAFETGDILVTCRPFIHIIADSWRGKICDLCLRQPIGSKNLYICRDCQQIHFCRSCQQLQSPSIFKNVHNLECPLLAKYGHILSSSSRLFLRLYLRLTNPESIHYQPIFNPLTREPINFEQLELAIIIEHNELADRITICCEKFANKSDDNDEQSTDMTTEEFALLQFIGLLDELRLCRDDDDDDDDVGENEILSMISDDDKIYELWKIFVRLWSYTLPIFDETLTGLFLKDAIAYGLYLEPSILTADGVHSCIPNCSFIHYGPVIQLRAMKSIEIGEQLSINYVDISLSRMERLKQLRNYYIGDCICIRCMEEQNDGNDMIDIDLFHSLREEFITQFQEEFIDSTLKNQSFLNFSTTSNNHDENEMIMKEKCLKMSQLARQLDEQYQQLYLFEHPEKSRFLFAFMAVEMNLLLFKLEFREQLQQQQKQHANMLINTMNGHESNGGRSQKNSRESGSITTLDTIIIEIKYWSDLLKRTVRSIRITHGIDHRLYREYPVPILNIWHKTLPKSLTLERLYQDPGILMSCSLSHDSSFSKEFLSEQFEFIKGQFAKLFNDKQQQQQQTNIIRQEKSESINKKRYDHYKVLFRILLVIFALLFPFFIYFTMYLENSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICC7</accession>
    <name>A0A922ICC7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICC7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7410" checksum="91867540176BF601" modified="2023-02-22" version="1">MAHSILFQNSHSIPQCLVDRSVANRRNKKGERKVNSDINVSPRTFLVYGDILAFLIILGQGYVPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDQ9</accession>
    <name>A0A922IDQ9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDQ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="8005" checksum="690126A0A8466893" modified="2023-02-22" version="1">MTKIQKCPSYIKAHHHFENEEEKTDVQTHHHHHHNEMNKYTVKLQLNPQFGLLFFAFITIKLPKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDS0</accession>
    <name>A0A922IDS0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDS0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="6912" checksum="D41EB41AB5C71633" modified="2023-02-22" version="1">MAKSNLVKIKISPLGIENHQYPSSLRPYHVEKTGSRLITKVKLRRAELVLGRGTTWEHSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDU3</accession>
    <name>A0A922IDU3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adiponectin receptor protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ADIPOR2_3</name>
        <name evidence="9" type="ORF">DERF_004075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDU3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9530257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="520" mass="59078" checksum="8EE749CC8B5C00AB" modified="2023-02-22" version="1">MQTYATPSQSKLSCSNHHHHAHHHRSVSLCNYDELLCRTRKRSEINSDLIQRKMIPITGGQPLECPHYNNDNQDDDEHCCEECPLNNDVPCDNNNEVFNTNITTNQTADDNDGDGQQSTNHNNSGSSSGGGGESTIINMLNSDQSLRVLFYPLKFSCSSSFLTTSNNPNRQPSSSSSSQQVKGHRRSLSLRQQFEYGYDYIRSEWEQARELAGKTVEQATKTVSQATGAVWKVCHFNMLPNWMQDNEYLHTGHRPPLPTFWACIKSIFRLHTETGNIWTHGIGALLFVGLFIYEFVTISAHKTAVDRLMLTIYFCGIIMCLLFSCMFHTFSCYASPKVIKIFSKLDYCGISIQIIGSMTPALYYGFYEDLNMFKLYISFGVVLCILSIAVSLWDKFGEPQYRGFRAMVFLCFGLSNVIPGVHWYLILDSRLLTAYYLFILQGALYVIGSLLYANRIPERLFPGKCDYMFQSHQIFHVLVVLAAFVHLNGINLMAESRLHNHHNLMQNHSDVLVSTTSSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE75</accession>
    <name>A0A922IE75_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL36m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L36, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MRPL36</name>
        <name evidence="9" type="ORF">DERF_002355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE75"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052143">
        <property type="entry name" value="Mitoribosomal_bL36m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL36M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9528405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="134" mass="16489" checksum="EEF23A51E6A16D8A" modified="2023-02-22" version="1">MIQTCPNLNYSKTIMLRNCLNIMTNLWRIAQRTNIQTTLIRPEFQLPLSMDKFPMLQQQQIRTFKDKDVLKLRCSKCYFKKIDDRWWVLCNEHPRHKQRQKLSRIQQQDEMIVTHITRTGSYKKKHYQYLYHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEA8</accession>
    <name>A0A922IEA8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CTP synthase</fullName>
            <ecNumber evidence="10">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CTPS1</name>
        <name evidence="14" type="ORF">DERF_003044</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="10"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEA8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="12">
        <location>
            <begin position="328"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9529142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="602" mass="67745" checksum="4EC674EE3AFC3387" modified="2023-02-22" version="1">MKYILVTGGVISGIGKGVVSSSIGTLLKSMGFIVTAIKIDPYINIDASLFSPYEHGEVFVLDDGGEVDLDLGNYERFLDIKLHRDNNITTGKIYQKVIEKERLGDYLGKTVQIIPHITNEIQEWVERVAQLPVTEPLAVCDDGSNNLSDESSGQVPDICVIELGGTIGDIEGMPFVESFRQFARKKGPENFCCVHVSLLPKPKSTGEHKTKPTQVSVKELRALGLSPDLIVARSEEPIDQSIKEKISNYCHVDPDQVICLCDQASIYRVPLVLDQQGLIEYFSKKFNLSIEPDPSRKFLHKWRRLAERHDRLLKTISIALVGKYTKLEDSYASVIKALNHASLTINRKLQIFYIEGSSLEETTKQHNPSEYYEAWQQLCKADGLLVPGGFGGRGIEGKILAIEHARQKKQPFLGICLGFQCAVIEFCRNVLGMTNAESQEQNPDAKEKVVVEMPEHNGGNLGGTMRVGRRETIFVHKDSILYRLYNPKNDRVYERHRHRYEVNIDMLDRLEKAGMRFVGKDTTMLRMEIMELRDHPYFVGVQFHPEYTSRPLKPSIPYLGLLLASAQKLDTYLARIESPISNSDNDVSDSDSTDSIVVVKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG23</accession>
    <name>A0A922IG23_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG23"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="78" mass="8941" checksum="D8C1E583F17CFDFC" modified="2023-02-22" version="1">MIISPPPFLPPFLPLDLYNNAGPQPDLPPIMNRSPPFLSPASVIVMIIIDKVMYITIQQPIMAILLQHLNIFFYYFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGM3</accession>
    <name>A0A922IGM3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein with similarity to mammalian ELMO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LMO1_2</name>
        <name evidence="9" type="ORF">DERF_003368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGM3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09388">
        <property type="entry name" value="LIM1_LMO1_LMO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000015">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF1">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="172"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="236"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9529484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="402" mass="45170" checksum="168835BB635C7AD2" modified="2023-02-22" version="1">MNELIRKVICNLTIEPFQDRQCQQIFSDFLFISSLCNITIPRQRQRQFSFITFCKLSKKNNELSSILFILFIYFRNIYFTNLISSHWIYYLMEIKSSSNMGFHHHHHHHHHQNNSNSQHNHNHRSSNHRIMTNSLISTNNSNNHNNTVVAANNNNIGSTTTNNCQLLMPMGSNCAACHKPIRERFLLKALDQLWHEDCLKCSCCDCRLGEVGSTLFTKANLILCKRDYLRLFGATGMCSACNKIIPAFEMVMRVHGDRVYHLECFQCSQCNHRFCIGDRFHLYDNRILCEYDFEEMLVFGGGNNGNATATSNSNKISINNNHIDKLVKQTESTLASFSSSSSSTAGSVVSTSGPVAIAGTSTTQSNQTAQVAAQQAINPSSNHADDGSSGYGSPDSLLSDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGU5</accession>
    <name>A0A922IGU5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGU5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="84" mass="9873" checksum="540FA4F0BC5485DD" modified="2023-02-22" version="1">MDIKLFENGTYGLNSLVFSCRVRSMEIHSGIGRWLHPTGLKKENIYKLNSQQKETGTLEFGCKIRNVITVTIMRKYKEYYHIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGW3</accession>
    <name>A0A922IGW3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGW3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="121" mass="14160" checksum="2F115C26C7053B19" modified="2023-02-22" version="1" fragment="single">RFSVKSIISNKNYLRYGNHHQNHHLLSSSDWLELMLLSHAVYTISYQMFDEFDETTTSIITAKFDGYYDLCHDEDPQYPCIGVSKLTIITTTTIESITSRYFNIRNNNNHHNYKDGVALDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KWX0</accession>
    <name>A0A922KWX0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KWX0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="126" mass="14175" checksum="67C27B5973B8CB2D" modified="2023-02-22" version="1">MHHNQYVLHVMTKQISSIQSLNVWKFSIFQYNPTLVPVQYDHKRNSLNDSFSTRTRFGCKRCTTGGDESISCLILATGDVGGIIAATVVVVFEILSFSNDDGNLFDSVVEFCIQILQLLEYTCVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KX02</accession>
    <name>A0A922KX02_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_013789</name>
        <name evidence="10" type="ORF">HUG17_0887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KX02"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048420">
        <property type="entry name" value="Zap1-like_Znf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21816">
        <property type="entry name" value="Zap1_zf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7645349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9497834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="430" mass="50520" checksum="082D5DD84199288E" modified="2023-02-22" version="1">MSEIIDLSDLIVNDEDNDDNELIYQNLLYGETIPNNTILSSPSSSCSVSYHHNERLTSSSSCSSSTINNNYDHFDDAFLMQSFPFTSQQQQQQQQQQNLFKFESSFFCYWLNCSKSFTTLKELNDHIGYDHVEPQKYHVHQQQNSGKKFICQWYNCMRDRKPFDQRYKLINHMRIHSCYKPKLCQYPGCGKSFSRQENLKNHYRTHTREKPYICKIGGCMKTFTNTSDRAKHRRVHFDPKPCRCKFPGCTKAYTDPSSLRKHRKNKHATNRNLSESWSMSSSSSSPSSSFTNMNYDNSNLAHSWPNSIFTNYESNELNSNQNVQNYESYVTQPMQPEQNGSQNHHHYGIINNEGLMIMANDDHQHYCSDSLQSQYNDSSSFRSQIVEQNFHFNNYSIDEQVDYGNGIINNHHYYQDNDLWQQNNQTLYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZA8</accession>
    <name>A0A922KZA8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZA8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="413" mass="48513" checksum="5D7539BDD111EF1C" modified="2023-02-22" version="1">MSILPKLINDFCFKMDLNETIWPLDISLYNSMPVISSTISWSMSSFQNFAQIEREKVDRNTSCNLRAGLFPNEIFIIYGEQYICSSSYEIYLMLLHYYRCSISFVVSNESYGGYLTSNGSWTGILKLVQQNKIDFIPHMFSMEYNRHQLLDHKQLFPQEHTTTMLTQKHYLINDDPFRLFHAYTLDIWLLILTSFLCFTFLTNSLECLIAINLKEKFCPSMFIVHHSSNRSNQWLRFHHIVNNLIDMFTLFIGQVDGQHILIIDRGRAQLLENFYENLKLHVSIEGLPGTVVNIAIRKNLDNKIKHYLRQLSKVIHGMGIWNLIWRRSIKFNWLQSELSRLQNQWILTINDIETNVKEISEINFKNRILHNNNIGEHSLDTTNTSSLIYIYLFGVGLSIVMFMVEIVYFVING</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZI0</accession>
    <name>A0A922KZI0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZI0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="7154" checksum="1418B988310D53C3" modified="2023-02-22" version="1">MNYYYCYIIKIQVTKKNEGVWYKNNNDKMFLFYMDAKGNNLKDKHADTNCYQKNPLSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZU8</accession>
    <name>A0A922KZU8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_015017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZU8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="8067" checksum="FD45AC32E3CCDD98" modified="2023-02-22" version="1">MQTDENLIPEQNIGGKKIQFSNIEAFLNRGSIEIKLRKKNETMNEQKTIKKTTFEQLFVFFFQKTKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L011</accession>
    <name>A0A922L011_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RISC-loading complex subunit tarbp2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Risc-loading complex subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TARBP2_3</name>
        <name evidence="5" type="ORF">DERF_011142</name>
        <name evidence="4" type="ORF">HUG17_5922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L011"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070920">
        <property type="term" value="P:regulation of regulatory ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051247">
        <property type="entry name" value="RLC_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205:SF3">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="110"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7643560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9506408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="363" mass="41138" checksum="096819886C8229E4" modified="2023-02-22" version="1">METPAAILNQIVIDNITDAVYTLLPCKGKLFQYRCEVKGHIEEALGQSKKKAKQAAAKKMVIYLLNDSKLTIAGNLDQIHAILDQYDEVGASNELKEKKEATQIQQPSSNTISDLQILCSRKRWESPSYNEVETKGMPHDRVFVIECFIKEMNLSATGSGKSKQQAKHDAASKMMAILKNENLDKSDEILDHHSKRNKVFEYQPKTKFDIPKAIDDFLKNEEKNQLKAYNTFNFFAKITSDAEKMGKMKKLIPNGIDFIQHFFAADETVDSNNIEILAANIAQIFDCKLVLSCLPDKSSVGQYQYLAEFFTTDESPGTLPLITVWGADNDLIMARIKSVRYLILQIVFYLSINENFNCHSENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L102</accession>
    <name>A0A922L102_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DIS3 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DIS3_1</name>
        <name evidence="13" type="ORF">DERF_008992</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L102"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RNB" evidence="12">
        <location>
            <begin position="135"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9510472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="617" mass="70550" checksum="757D56937A6453F2" modified="2023-02-22" version="1">MKPKPFGRIVAIIRRNWRSFCGVIREPKILTSTSSNFIFVPVDKRIPFIRIETRQYQQICGIKILVRIDCWPRDSRYPRGHYSRVIGESGDKETETNVLLLEHLIPHMEFSAQVLNCLPVEGDKWQPRIDDLSNRSDFRQECVVSVDPPGCTDIDDALHCKDLGNNQLEVGIHIADVTHFIRPGSAIDREAAERGTTVYLADRRIDMVPGLLSSNLCSLISGRERLSFSCVWKINSKTGEIYQTKFSKSIIQSRASLTYAEAQTRIDDPEDQGEIAQSLRRLNSLAKILRAKRIEKGALVLASANEIRFVEVESETAENELVILEKQALETNSMIEEFMLLANISVAEKIYEIFPELAVLRRHPKPAQSNFEELIVAARNRGFDINVSDGKSLSASLNSIHDPSNEHLNLLFRMITTRCMSQALYFCSGSLGSDPNLTFFHYGLASEIYTHFTSPIRRYADVLVHRLLSHAIDFEQQPPEFLCKRKITDICDHINMRNMNARRASRSSNELHSYLYVRNSREKCCHEKGHVFTIKNNALVIFIMHLSFEVVYMFGDGDQSMNDWQVDKDNGFVIHKPSNVRIRQFDPVQVELTVKPSALTSNFKKQIIVRLIDSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1N4</accession>
    <name>A0A922L1N4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1N4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="8562" checksum="79C18617AB157BC3" modified="2023-02-22" version="1">MKGSFIFTFSRARPKCQRSSHHQSSVSQSSFYERVLLLEFDQLLAHSLVIKIGENDRKNKPSKRNHHHHESET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1R5</accession>
    <name>A0A922L1R5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1R5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7592" checksum="31EDCD58542BC254" modified="2023-02-22" version="1">MKKNPLNQHLKNYEEKKTNPIPVIRQSHNHDHQHQCEIICTTISAILCHRLIDVRQMFKNEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1U8</accession>
    <name>A0A922L1U8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ARPC2</name>
        <name evidence="10" type="ORF">DERF_011653</name>
        <name evidence="9" type="ORF">HUG17_10048</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1U8"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000002">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000004">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7643357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9506947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="301" mass="35495" checksum="086DE04DFFF05B2D" modified="2023-02-22" version="1">MILLEFNNRIIEDVLRLKISEYEKNNKADSVEVKVADFDGVLYHISNPCLDKTKIRISISLKFYKELQQHGADDLLKREYGDFLLKPPENGYNVTLLYDLNNLPTDKESLIEKASLLKRNCFASVFEKYFEFQENDIQDTKRAVIHYRDDETMYVESQIDRVTVIFSTTFKDEDDIVLGKVFMQEFKEGRKASHTAPQVLFSHREPPRELQDTDARVGNNIGYITFVLFPRHTCKSNRDNTINLIHTFRDYLHYHIKCSKAYIHSRMRAKTSDFLKVLNRARPEKIEKEKRNIKGKIMNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2C0</accession>
    <name>A0A922L2C0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pyridoxine-5'-phosphate oxidase</fullName>
            <ecNumber evidence="7">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Pyridoxamine-phosphate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DERF_013467</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyridoxamine 5'-phosphate + O2 + H2O = pyridoxal 5'-phosphate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15818"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:15150"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="7"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2C0"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000020">
        <property type="entry name" value="PNPO isoform 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="16">
        <location>
            <begin position="69"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="17">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9497475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="240" mass="28506" checksum="F3B43D7057CC11CB" modified="2023-02-22" version="1">MSKTLSIFSFIIRRSINLSSTMSADLSDMRKPYCDKSQALTDENILSDPFELFHQWFENAKQNAGKHTEINAVCLSTSYQNKPSSRMVLLKGYDPDHGFRIFTNYESRKGSEIEQNSNVALLFYWEYPQRQIRIEGQARRVPESISDQYFNARPKLSRISAIVSQQSKKVDSRETLLKRQEEEEKRWTDCDVIPRPNFWGGYFISPERFEFWQGQSDRLHDRFIFEKSDQKTWFHYRIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L340</accession>
    <name>A0A922L340_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BCAP31</name>
        <name evidence="9" type="ORF">DERF_010017</name>
        <name evidence="8" type="ORF">HUG17_0074</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L340"/>
    <dbReference type="OrthoDB" id="6500863at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7644536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9511566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="230" mass="26480" checksum="2124869908CDAC28" modified="2023-02-22" version="1">MSLQWTLIATFLYVEIALIVLMLLSIIKPRFWRSFFQSRFMTVVAAQSNLYLVAFIGVLLLFFVESVREFHKYSSKLNTNDRMYVGSSAFYEDQMRVFRGQRNFYISGFALLCVFIIKRLIRLFGEMAQLKAESEASIRQARNAAELASQTLSASTKTTTTTNNDQQQIPLEKENAALKETIDELEKKLKKAQTDLKAMERQSVNTNKAFDEMAEKLARYEASADSRKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3F6</accession>
    <name>A0A922L3F6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Brinker DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_011789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3F6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00034">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018586">
        <property type="entry name" value="Brinker_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09607">
        <property type="entry name" value="BrkDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="TrpR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brinker DNA-binding" evidence="5">
        <location>
            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo shadow" evidence="4">
        <location>
            <begin position="227"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9507086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="35341" checksum="18D019DB77F0203C" modified="2023-02-22" version="1">MESTPMKRMSYTAEFKLKVIKYAKIHGNRASSRYFNINEKCIRDWRKRENELRRMPKYKRSNRGTKRLIRPEHIEYEHFNGQPSNDLVEINDDNNDGDDDVDISIEVAPDISEDLLNGLDDDVSLDFIKQENNFPQIMYDVYESNESTFKSNEKENNESKTNQMDFEIELKNLDESQPPPPSSSSSTSTTSSTIEIRTNDRKKRKKIIGPDKETGTLFDFGMKAIKVIGAIELDDKNSNQTKNLCYVIKFENNQCDIVMNKVAQKFCPQILFDFLESRIEFDEKNDIHLPLSMVKSSSDLLLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3N6</accession>
    <name>A0A922L3N6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">IkappaB kinase</fullName>
            <ecNumber evidence="2">2.7.11.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_007465</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19073"/>
            <dbReference type="Rhea" id="RHEA-COMP:13698"/>
            <dbReference type="Rhea" id="RHEA-COMP:13699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.10" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3N6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008385">
        <property type="term" value="C:IkappaB kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008384">
        <property type="term" value="F:IkappaB kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046375">
        <property type="entry name" value="IKBKB_SDD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051180">
        <property type="entry name" value="IKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969">
        <property type="entry name" value="IKB KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969:SF17">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9516746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="735" mass="86768" checksum="EE7E4202C9B33408" modified="2023-02-22" version="1">MHHSRQLLCDIGSVKNWQRVQTLGSGTFATITLWVNKDTDERIALKQNYMDVERYSKKQITYYYERWQQEITFMKQLKCENVVKALELPKEFSKLSLGMPILAMEYCSGGDLRKVLNEPTNCCGLSEKEVRQILKQISSAINCLHNLNIVHRDLKPENIVLQPLPHGKILYKLTDLGYAKQLSETTSANSFVGTFEYLAPELFLNIPYTSSVDNWSFGVIAYEIITGRRPFLPNHPVTEVLEAIKKKKSDDICTEIDERGNFYYSKEISQLNYISSILKSDLEKWLKTVLQFDPKKRGGRDAFKEIKQIVNKRNVQIFSIFSYETFAYEITEETHIDDLKEKIFASSNIIPANQYLFFQNGDLLKEKIGQQIIQTWYTPKSWFDRYNPITINMFDYSKEVNYQEFYKFLCLPNRVEMMLMNCDQTADYDELKFTWRSSVFVARQTVAKYRFVHETLKSCILNAITMFNRLQNEDAMLYNSLNQMFSTINAMEKLLKKNYLKFSNTEETNDDVKDSNHISSSSSSSIFMKLKNLHDWRNNIYISGHFERNGQIVPKFDKEKFMFEDFFQSPEIDESLMNKYVDIQKAYDMLRKLKKDEYKKYASNNLMVKLLCDIFKLVETLMKKMFSLLSILISFIRNIRNQQRDCQRIKIELDKWKTNELEELQQMIFRKTYHEYPSSTESSTEFLASQVISLDGCKDSINRQIEILSEFERENSQWQSKAFVFESLEFKDFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4S4</accession>
    <name>A0A922L4S4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA-processing protein FCF1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FCF1</name>
        <name evidence="10" type="ORF">DERF_008867</name>
        <name evidence="9" type="ORF">HUG17_4780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4S4"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="8">
        <location>
            <begin position="68"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7641735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9518278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="197" mass="22875" checksum="CF59FA63CA5E3C01" modified="2023-02-22" version="1">MAKTRTPKLLSMKDSRVKNQLEMKPRPLKKKEREKVKKAAKRAERQNQPAIVSTTMFFHYNLQLGPPFRIICDTNFVNFSIKNKLDIMQSMMNCLLAKCIPMVTDCIVAELQKLGQKYRLALKIVKEQFERLPCSHKGTYADDCIVNRVTQHKCYIVGTCDKALKRRIRKIPGIPIMFLVGHQYTIERMPDAYGIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L508</accession>
    <name>A0A922L508_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L508"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9512020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="658" mass="75050" checksum="C25070EF65DBF1CA" modified="2023-02-22" version="1">MAPSKETATNNNIDLRSSSNQQPSDDFEDDEHSLPIPELIEMLKNLAACNEKLYKWEQSTVKLEQIPADDPNKQQLNEIINFVNLKTGSTREKAIYLYQRLGRKCSQHGNYIGAAKAFERAASLLMDPTDQSEMNNADDKTIMETIQCLESAIHNYDAIHKYKHAGTLHYRCSRILRLLSDFSHSQVEQHHIKALEYFTKPDHELKQRKRIDGLKISCYSSSSTWARMISSNIRMMKTKNKNNMMNTTHHKMITRTNHHLIKFLHHHDDDEDYADDEDDDDDELVTLVESDVENDNHLVNHRYSNDESDHSKRRKTLSMNNDNNIPSNSIHTNSGLSLSPSSSLSKIFQSTSPKSTSFDFNPINESTAKPMLKNFLDQHLSQNQLENRRQDAPIPSAMIFNESLPSTPTTPSSLASRDSIPSLPVGGGQQQRKRQRSVSPIRKYHKENHSHRSESIYKQQKHHNLETTSQEYLHRHSHRSYSSYHHNSSKSSNHQRPDDDDYIGIRIESVKDLIKKLHNVTTTDIDAGRVDCRICDRYLGAVSSTLKNHIGNYVPVNTNIINRSLQCSNIIANQQQQHPPLASTINQIQWHKQPTDLDTTNNNRESEYQAQQQLYRSSAATVVVNPSGNVQPQSLPFSTTAAVPTCGFLSSSSPYFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5C0</accession>
    <name>A0A922L5C0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5C0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9515969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="94" mass="11503" checksum="EECA9EB3898BF0C9" modified="2023-02-22" version="1">MTTVKNNNNNGNGDDDDVKRNRSIYSSNEKIYNETTFITDNNRHGQKSMTRSIRYDHDHDYNGWNKNQKGWRKYRREMRSTLPYRFIKRYSIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L611</accession>
    <name>A0A922L611_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PCYT2</name>
        <name evidence="14" type="ORF">DERF_009710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L611"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02173">
        <property type="entry name" value="ECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000108">
        <property type="entry name" value="Ethanolamine-phosphate cytidylyltransferase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="18"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="217"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="372"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="374"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9511238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="412" mass="46839" checksum="98F3A25443190E10" modified="2023-02-22" version="1">MDSDFNSSNDKKKITRVWCDGCYDMVHFGHANQLRQAKAMGDRLVVGIHSDAEITRHKGPPVFNEQERYKMILAIKWVDEVVENAPYITSLETLDKYKCDFCVHGNDITVDENGLDTYRYVKTAGRYRECQRTEGVSTTDIVGRMLLMTKTHHQIDSMDDNDLVKQSKQTSEHVEHIRRDSTTHSPYTGISHFLPTTKKIIQFADGKDPNPGDKIIYVDGSFDLFHVGHLDFLEKARSHGDFLIVGLHSDSVVNRTQGSNYPIMNLHERVLSVLACKYVNEVVIGAPYIITKELLDHFKVDLVLHGKTSIMKDDDGTDPYRIPKQLNKYKRIDSGNKMSTSTIVDRIIKNAMQYTLRNLKKEKKELELFRMLSHHSSSPSSSSSSSSSCSSLNENSDDNNNNNVDDEKDGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6J3</accession>
    <name>A0A922L6J3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_004784</name>
        <name evidence="8" type="ORF">HUG17_7737</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6J3"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000002">
        <property type="entry name" value="oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7640270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9521108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="404" mass="47518" checksum="849DD69216C59FF5" modified="2023-02-22" version="1">MFYNYSNVRCFAVAFCQFTRKCHQIYRKHQPLAQMHRKTGTAMLAFSFGSLFGFSGSSNDQYNSYYEFMAESITPKDELLSQAQNGSMRHQFELFVMQVQREFCQALESMETKYTDEIDETKVKRFHSDRWLRQEGGGGITCILQDSTVFEKAGVNISVVHGQLPPQAAAQMRSRGKHLSTTEPLKFFATGVSSVIHPRNPNVPTLHFNFRYFEIESNEDQKSNHWWFGGGTDMTPYILDEQDARHFHRHLKQACDKHDRNYYERFKKWCDDYFYIKHRDERRGIGGLFFDDIDYPDQKRAFAFIRDCAHSLVPSYIPIIDRNATKPYSLSDRQWQLIRRGRYVEFNLIYDRGTKFGLMTPGARYESILMSLPLVARWEYQHCLAENSKESALMEVLKNPREWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7H3</accession>
    <name>A0A922L7H3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000232</name>
        <name evidence="2" type="ORF">HUG17_8077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7H3"/>
    <dbReference type="OrthoDB" id="6511828at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7640608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="219" mass="25513" checksum="FF0A37AE02C5E59B" modified="2023-02-22" version="1">MAKITGKKSKLPFQFEFLGKTYKDHYNYEDFLYNATIFLRNKYPFLPLELLTARAKDEWNKKKIRNNKRNIVSKDKRSRTGNGHGKKKPLAFEAETNRKIRSKPKRNKLFAVNNFETTKQSMISEEESHEESHEKSTFEDPEIININDESSSLMEDFLNRESSEIVSEQSMTKCSISDAYLPIHFDGDDENRLTTTIEEVQPAKISISESNIPLYLSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7T1</accession>
    <name>A0A922L7T1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7T1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6741" checksum="409B29567655EE8E" modified="2023-02-22" version="1">MTTYLNEFHWHSSSKPPSSPQQHSTLLNGSLWTKKIYNGNLPTKTNNILSPLKSELCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7V6</accession>
    <name>A0A922L7V6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7V6"/>
    <dbReference type="OrthoDB" id="10456775at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="200" mass="23281" checksum="3ED356482D570842" modified="2023-02-22" version="1">MANTRIHTLEKSSDVTYSNSKLFNDDFLTNKAIGADHIVNKENEIISGKLFFCIEKFVFSNQTNDKIISLIGDESSIVGRKFVREFQSLVGFLVDDLNEIFAIPPPDSVLREVSLKLFFEHPDLSKRYETEMKAGFFSDELFVNCLQKKLRNKFQVAERKLKIQLANSEFDRHYYLERKKNKKISIQKTIKKALTKENDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L810</accession>
    <name>A0A922L810_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHHC U11-48K-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_000770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L810"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022776">
        <property type="entry name" value="TRM13/UPF0224_CHHC_Znf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05253">
        <property type="entry name" value="zf-U11-48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51800">
        <property type="entry name" value="ZF_CHHC_U11_48K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHHC U11-48K-type" evidence="4">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9526706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="191" mass="22575" checksum="1303647A11716A89" modified="2023-02-22" version="1">MHFVFISKKIIYIVSPSIGHIDMFVVFPGFSFTVKNEQVESNIKLTNCDDENMATSCCHSKYLICPINSNHKVNSKRYDDHLLRCRLMNLEKLDTTSQNESEISIYSNYEDRSSSLIGEQNDHSDLTHQSSFTINHDLKSGEPTISIDWKRLEQVDRFQYIPYNILMMMTIDQRKRYKDCLFNYTKQHYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8Q5</accession>
    <name>A0A922L8Q5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001496</name>
        <name evidence="1" type="ORF">HUG17_4644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8Q5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7641599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7988" checksum="616ECD5344CDEF36" modified="2023-02-22" version="1">MNSIPKTNDLSTSMLNVDVDPNDIIRSRIMKTIDLDYRFENLNHLKFNSYSKPINDHIRTVIQQRPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAH8</accession>
    <name>A0A922LAH8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylinositol N-acetylglucosaminyltransferase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_004786</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAH8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9521110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47928" checksum="D2904A01636077DF" modified="2023-02-22" version="1">MVGSLPDLMDHFIDNDNLNPFTSMTNGYISNNNHHHRTISNHVAQNYNSNDNNFKKTNGSFNFNMAKSNGYNSSIKESISSSSSPERNDQEWQKVLYKRQGVPDNYVPTTFLKDLRKNVNLRRFHLMEIIVAASIVTQQIVLIVILIMMFIYFDSYDNHYDHILFTIVALVTIFLYTFIFISSKFQEIIQIKSCLIFLIACFTMSPVLKTLTETISTDTIYAQCTIMAFVHLAFHDYGLDAAMVSQPISLNAIFFASVCLASRLSTNYHAFAFLIFSTDLFVLISSMYQSFERQTKLFTTIMFTIITLIIIELTFGLVGFFASIIFVLFINLICPYIFLRMQILKDNIYGPWDEAIIDGNALKFSSKNFKKKFIINGFHHHHNHELSLNFQYSNKSSESSNPSSPLSPMNVSNIFTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAJ5</accession>
    <name>A0A922LAJ5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ARPC5</name>
        <name evidence="8" type="ORF">DERF_002362</name>
        <name evidence="7" type="ORF">HUG17_10315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAJ5"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7636345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9528413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="153" mass="17241" checksum="BDDB74EA562AF823" modified="2023-02-22" version="1">MAKNTLSSQFRKIDVDQFGEDVFKEEDQLDQSSPAGLNVDEKEICNLINSAKQKDALKLVLNSAPIGSKSQYLRDANLQLALKVLLSVKISEIEAICNELNFDEIDILMKYIYRGFELPSDNSSAHLLVWHDKAFQKGGVGSIIRVLTDRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAW6</accession>
    <name>A0A922LAW6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_003757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAW6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF40">
        <property type="entry name" value="CUTICULAR PROTEIN ANALOGOUS TO PERITROPHINS 1-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038115885" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="506"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9529901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="680" mass="78693" checksum="A977EEAB563487F7" modified="2023-02-22" version="1">MRYKLAFIHYMFMIFMTLKNECLCDDDCHNCFAISQYYNHHNGNHYQSYPISVINNPDQRQYESSVNYQYMHPSQNDGGTLNYGHHHHHHQNYQQQLQSQQQQQQQQQIHSSLLSKPLPPPPQPPPPQYRPIIMAYHPRVNNRHYPFFTRNSDHLLDDSPSSRSNNDNESIIDDNTTDEQQQQQNQQQQQSFVRVPQKSVRQRISNQYWPPLVNHTFGNSIGNFATTTTTSTTTTTTTTTTTTTTTTTTPAPPPFSLDDYEEEFHHEMITNPRLPSSSLSANANNNNAQEFSSSSSSDHQPNSNNRVLSRIENPIVSNNIENNNNSTIVDKNNKFDNTNFENNNGRFGSGRQRKRQRTTTTTTTTTTEPPYYDDGDYYDYDHDDYDVYDDYDYLATTTTTTTTTTRRPRDRHYRGRGGHHHRRRGGGGGRRRYHHHRHNDDDDDELLPAKPTEPSTTTTTTTLSPNYKPRPDGRIIDYHADPNFPYELKGADLTDYPFYISIPETDFNCKGRHDGYYANIDLKCQVYHHCAIGHQRYDFLCPNYTLFDQTTFTCRFVNTVDCDASENHYKRNNELYVESTTNGPQNNFYNSYHHQPPPSSPQSESLQSPPRSSSSNNDHLQTSDSSSSSQSQSQNNDDDNDNYRPNQLPLIRLNKRPPLPLPPPSPPQQQQQQKKPQQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB93</accession>
    <name>A0A922LB93_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB93"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="263" mass="29687" checksum="3252CBCBD2E73BC5" modified="2023-02-22" version="1">MATCRQRKIVRSKIFINGMEKKMSCINHYGNTFGWHEFHDVIFYAKLIGIDPISEPELLWIARAGLLSSLPSGWIAVIDEVVDETEPEYHKNQHSDDDDESIASLKAVVLMRNSTNNNEEQTLETKSTIAKIETPATSMKKDLDEDGDDDDIIFSDLMENLIQKDVFNNSNDRTGNHEQQRKRPQSARQPSSSTITKTTITAKTSMNEILLNQHQPELSSNKSNISNNRTIMARTNTATSLEAVFEEDDEDGPTDEPQNGRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBM9</accession>
    <name>A0A922LBM9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neural proliferation differentiation control-1 protein (Npdc1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NPDC1</name>
        <name evidence="4" type="ORF">DERF_003616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBM9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009635">
        <property type="entry name" value="NPDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23352:SF2">
        <property type="entry name" value="NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23352">
        <property type="entry name" value="NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN-1 NPDC-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06809">
        <property type="entry name" value="NPDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038055200" evidence="3">
        <location>
            <begin position="21"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9529749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="481" mass="54038" checksum="913ABCBAC04A2032" modified="2023-02-22" version="1">MKQIYLTTCLLLLTLNLIDAFQPQQQQRVKPQNKYEPFSTSYLRTLLPYGGGHNNVYYRRPSQQQEFDLRRQQIDEDPSETEAAAAASIQQQLALLNDDAGVFLNGPEGLLSKYKNLNRPISVAALQRKQTYNQQKQPISDEELNRLFVSIQNIQPPIDERNDDYLNLNDENRASEQLLDFANIIGNRQPAAADAIINDNINYGNSDFNRKWKLQKHLTSSSSSSPSPSSNHGQQQQQHQQAPVYREENMAIPYDEIEQTKKRKETKNVSVNNNGDDNQSLMEKKRLQVPSNVMNNEHSIQAPKSYQQSIINTKSSIQSKFSSLSDIYFIAIVACVSTIAIFSVIGAGYCFYKVQQSNKAAADVDFPAYGVIGPVSRNDGNDGNKCTSPNNDHIESDEENEDGEYTVYECPGLAPTGEMEIKNPLFQDDITPMSSPSVNGSTATSKDTTPKDNDSKQSINNQQQKQSQKFDNNLNKNGKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCV1</accession>
    <name>A0A922LCV1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DERL1_1</name>
        <name evidence="9" type="ORF">DERF_004050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCV1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9530232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="265" mass="30606" checksum="90CFF444123B72CA" modified="2023-02-22" version="1">MSFMNEIMAEIKQWFMSIPIITRYWFGLSIAMPVLGRIGLLNPYHMFMTKDALWRLELWRPFTGTFYYPIGPGTGFHYLINLYFLYQYSKNLETNEFVGKPADYLFMLIFNWSALVLMAVFMNIFLLMDPLILSVLYVWCQLNKEMIVSFWFGTRFKAQFLPWVLLGFNMILGGGGFFEILGILTGHLYYYVKYVYPRDQGGELITTPAILYRFLPNYTPLRSTGFLSFPTASSIRSQRNTASNDSSTSSSGHNWGGRGHVLGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDJ0</accession>
    <name>A0A922LDJ0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Choline dehydrogenase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CHD7</name>
        <name evidence="12" type="ORF">DERF_003335</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9529450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="4307" mass="473516" checksum="9A6EF0CA79454477" modified="2023-02-22" version="1">[encoded data, 4307 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDQ7</accession>
    <name>A0A922LDQ7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CDC7</name>
        <name evidence="10" type="ORF">DERF_003955</name>
        <name evidence="9" type="ORF">HUG17_5798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDQ7"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="67"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7642751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9530125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="677" mass="76578" checksum="CC47DBC37958DD90" modified="2023-02-22" version="1">MTESSVGKKTSPMFNTTNQSRNTIVLNGHNNFSSLRIEDPKKATSSLENDVYMKIMMNNVPKIAQYFNVVDKIGEGTFSKVYKAKLKRGIETDDNNNNNNNNNNDDGEECKYYALKYIIPIVKPARIAKELRFLRDLGGHSNIIPIKTCFYNSGHTVVVMPIVEHDRFQDYLCDLTITEIRSYMRNLLIALDRVHSHGIIHRDIKPSNFLYNRSTGQFALVDFGLSQSERELYHTINLSLYPYPNKSSMKTTITNDSKVRKNLSSKFQKNSTKIEDVQLKRSFNEMNNQSNVENENAKRKKLSHPQQQQQQTSSIFISPLTPSLMVMKNKDSKTSSNSLFVPGTPVKTPFNEHDTNACTTFQPEIPDTPIKDQYAYKTPTKTGEMRVDNVNKTPIKTAVLSIPETPPKTVQKNLQFSRATPPSLVNPKYKENVNHYNTPKTISKPMNFRFQTIKKLLHPELSSIQNGNNNTVNGVDNNLTISKLSQHNHQQRLCDCTQTATICHDCLSKIELNVPRAGTPGFRAPEILLRYPNQSTKIDIWSCGVIFASLLSGRYPFFRCNDDISCLAEIITLLGSSKVKRAANALGKTLTISRRSIPTMDLKKICIKLKTTSFPPTADDKSTTTTNKWYQAPDSAYDLLEHLLDPNPRTRFSANEALSHPFIIGTDNLSLDDVKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HEX2</accession>
    <name>A0A922HEX2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">La-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LARP1B</name>
        <name evidence="6" type="ORF">DERF_016711</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000010">
        <property type="protein sequence ID" value="KAH9490513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008187">
        <property type="term" value="F:poly-pyrimidine tract binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000131">
        <property type="entry name" value="la-related protein 1B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006607">
        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="832"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="499"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="965"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1060"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1152"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1304"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1350"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1645"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1770"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="325"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="573"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="965"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="996"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1016"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1060"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1350"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1645"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1683"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1695"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1718"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1775"/>
            <end position="1795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9490513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1795" mass="196183" checksum="846A8D91B4DCCC8D" modified="2023-02-22" version="1">MNNHTNNTSNSVTNPVTTIKTNANKQATTAIDCMKINHGHNNINLENGDLSSSSIKSAELSSNIESTLDYPKLTNEKTTTTTTAINNSNNITDSNKLDSDCIDNNNKAQKSSTPTGANDNVIIHNGYGTSSSLEHHNNHLIQSQLQTTTVVPNAWISSPGKLVAKSYNQTAPSPSLIPPSQQLSSTTSANNCQTTNTKTLLNNTHNNGNNKNVIPLSTTTTISSSSSSVMPISSTSTNTTVCTTTTVTTTSTSGVNNNKWSIKNGSNSASNSIVNNNSSCTNNASNNQKDEYNLNYSEDWPSLNEVNELSLNSKRNSAGETMVINSTNQNNNNEVVSSSSPLSTPSSPNIIAQNFESKTLAKTLSSSSSQPANTQNSNDNRKLSNNSSLPNGISVVQSSPIQDECLDDGSTTSSKDANLISSGQGLDSSTLTSDKNKHKKKGQKKWVPLDGIIGAPPAKLRGKIVNKTNDYYSVGEYNGINGYTDHEYKSGAAGGGGRYNSGNGGGNGNFSRNRSQRRGERGTGNGGNAGSRGPGNATGTNTVAVSNVNNSNNNEDNHRFGIGNANGSKVGPSNTSSSISNSNNMNKSNAQSEIIDSSSTSSSNPNANSNHNNNTNNHNNKKKNIISGSGNAVSGNNPNDSHHQYSHHPHPPHQHSHQQQQHQQHHHHPLNVQQQPPLSVPLYTRRNPNGGMRGRSRGGGLMGAGRILNRSRSQMSNESTGPVVNPTAAIVHQQTNGNVGVLPGTTVTATMPPPQPSVVTNTVAAVGNGVTAAPNIHPEEYAAAYPQYTAYDFPAQNIRPDMNSPLSAGLSTAPAPTAAFLPPSYYYNTPFVYGPDGIKEMLRSQIEYYFSEENLQRDFFLRRKMDEQGFLPISLIASFHRVQALTQDVTLVVEALANSTTIEVADGIKVRTRNDPQKWPILDNLSAAATTAIHPAMVMAAANLKSHQQSPENIANHQDVEIKSGNNDFDIVNNNSSCPSHVKNSSDGDPPKHQVSVANDDQSTSDVNSIHVTNIAQSQQTTNSSSTTADTQSNEDEIQQQKQVIRNQSQIHLASVISSSATMDGSAVPTTTPVSGNNTDSQSLSSNAEPSVVEIANCDKSKQVNSPDGDAKSSSIDSQNRETAYVNANSNSDNVNVTASTTVSVANEIEDWKPVRSKKNKSRANKSNEHSSHQSSSNCKTINRLTTKEDLPFLLDEDVHDAEEFQLTGRRKTYIDYSDYDDYDEISDQDLKKIILVTQSRKGNQLNDRTGDWTTRVKMTQEMAKIIDDGLFHYEQNLLLNHQGSNTKQHKTLGYISREDFELYSGSPKDKKENAYSTPPPPPPTLNDDIKLDEVYTTTGDHTLSAEELQQSAKSLQRKSPNPRFYLAPEPHELLPAGTPRKQKTRHSSNPPIEPHVGWLLDVRDHETASMNADATLGMNSDGNKDDKNVIISNTTNMQSHQTNTGSVSILSTSLGSTPQSLPKFEHPSHALLKENGFTQFVYHKYRLRCIKERKQLGIGQSQEMFTLYRFWSFFLREFFNRNMYEEFRRLANEDAQVGFRYGLECLFRFYSYGLEKHFRSDLFNDFQKETIKDVDAGELYGLEKFWAFRKYYKNWCSIESLVDPFLLQKLDNYKSVDDFRLDAETIAQRETQNRTKREEYVRNFQQEQQQNSSSNKKKGDGNGNVFVGKNLNRRHQNTMIGDENKHQFSKQDNRTQSSKSNIGSNKPVKDAIVGKNGDQSRTSSNINAKQPMRQSNNLQTNNIKSVPMTPQAAPVNSPTSFAAIVASKPKKLAETQSATGTTAATSNTENSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HFD6</accession>
    <name>A0A922HFD6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_015851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HFD6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9491116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="90" mass="10234" checksum="7388E722DEEA73E4" modified="2023-02-22" version="1">MSNCIILIDKNFHHFILTKQGVPQRKLNTPTMTIHSFPLPNCRALFVSESRSIGMTISTFIRCVTSCERNTSLTFSANSFRRFSNSSQDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKY8</accession>
    <name>A0A922HKY8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_015069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKY8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18559" checksum="7950FA8A21A2DE32" modified="2023-02-22" version="1" fragment="single">TVLLAGQLFRLETSIQMVQNPKKSQSKPKNNKNRQRMDKYAKLVICSTNSFLTTHPTTLDDVPFSSEEAYDAILTENDNKSPARYIPGQMESIYRQSNPTICGESAEKLLSRGCPQGAKCSPLLWNILYDNLLKLHLPTGCYLQAVWFPKCLYVLHPALPKNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLR8</accession>
    <name>A0A922HLR8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_015973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLR8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9491241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="131" mass="15166" checksum="4E8EF755C68268AB" modified="2023-02-22" version="1">MGSNLCEYIQDTINIQYLIRQLLRMANDQTDCLADDCMDDGINNNNNNNQIENNLRQVDHGIGSTSLTFGYLMFTFLLIWMVLPRNYNPQSQSQQQQQRNRRNNQSSDEMKKSNHNNDHNDNDHGDPGLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HM36</accession>
    <name>A0A922HM36_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HM36"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="117" mass="13296" checksum="00F2D9888033B498" modified="2023-02-22" version="1">MNKFEYIKQQQRQELQAACDDDVIITPSLFLSSQKRSQAKKINVSHLYIQMMMMFILICECKILLLSPPTITPTSQENFSSSVLQDEETLCSSRFSLNNDGGKKHGSKFGTLNEQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMD5</accession>
    <name>A0A922HMD5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMD5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="184" mass="20891" checksum="DFB37800BF554EFC" modified="2023-02-22" version="1">MDLREFFDNIFNIDDTIEDLEKSFIRGNFIFDDGSLRSNIRPRDLMLKNSSTIRRSTTRNGGHHSIDNFFESFADDRQQNIGGGSIASKSQSVIKEFKSDSNGKFEEKIVIKDSSGNEKIITKQSDGSKTVQREIHKKDDKIVQDKEIVSDIGDDVRKIDIIGEKDGGGSNSTGSYWPYIWPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNM3</accession>
    <name>A0A922HNM3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_015045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUF2428" evidence="2">
        <location>
            <begin position="693"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="3">
        <location>
            <begin position="961"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9494355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1526" mass="178556" checksum="94C86ECE3F745540" modified="2023-02-22" version="1">MTMCILHKLNKENVYKLFTNLVESSIIGIEYLPSNAERILVNLSILFNHNLISKDFGFLSKLIAAIFRFHRIRRKNLDLYCHEDSTFSSTDLFGKFSFYFDNEFKLASLILNWMRKNVEKLNPDLNARFEHIIDQYRCLVIINAWYLLYSNDELSVFHDNIEPLSLEFNSEFFMTLLSTFLMESFKSPALLTLNIGNLIKQMLTIDHCDSNFVYHLALLQFNWAKTIKFIVENHRAKLSSTIIEIVIRQDVNEMLNFSIQNWSHTNVDYIFSTASLSIQILRIISMSSWFESYLINQLYPKFCELNHSDFRLFCIISDSIGIKELLQKSPYRQSQYFLKIILPKLFQHFPSSKMIVKQIFTYVFSVGDEQTLWTMRPDLILLLLQLNQKENLQIIDEKNAVQNFAEKFALQYINNNDDDLRLHTLRLLIESKMNKKDEFESNRIKSYISAIQKLRHHSTSIWSIARAITTQHKRNKTEFVGNNQIYYDFIQMICRYCFDNLHINRYFGSLLIYLQILHLLVDKLLVSTKPLLIMLQDSCITPVDRQSLMFMLQHSLQEIRTAAKDFIVSCYHLKLIAFTQNEINFLNKWSKTMLQSIQPRESQIGVILKQLTVSLDDNNGYSSHFDVIQTLIIELNQRIAVINVNITNSCTSPCYPLLLAIRTLLCNEIDLNKLKSDLQNDEQKLSSWKILFIQMIDSCMAACESIISIVCNDSPEGHLPAVENLENINFDFHDDHISELYMISQMLLINGWMTIKESVLIISHLVNSFPYHRSANETIISCVYIDKIIDFLYKNQLNLVHRGAFEQSSQGFNHLIASLLKNECKICRKKIESKIDEIKKRLQKREDDGMFPTYVSITRRSAGLPFIIQSIIAGDLNGVYCSTFIGTLVDILDTEKIDQNNQRQSWQIIHSLNILKSLIHDNRLSSVTAIWIEKLFKISILWFKRDTYNHCLHDSNSTNFVFGVKRNRLDTSRKNRMSSLSFFQSYPTLYSFILRQLESPQICYDHSQLLFINPILIILSKLIISKSANNVYDANKFLPLIKNIIYECRDARLRRLAVHTYSRLLSSNSYSNVIIDLNEKLIENEIKTKKLNHLHGLAMLVAEISREFCLQTMNSNTESKDLSSSSLIKLYDNLMEIFKNQWIMNGLVLGILHQAHYRIFVCLKSKNESIVFKDHTVILEEKLVKLITNNNVQDDYSVNLIIDYLIHSFIDSTYQTFFSTLDMIVASKKAFEAKLTLWYWLNSRILLNDHDVKLDPLEMDENDTLLLLIEQCIEDFDEPILNSSVWSKFVDNIENLAAKLENISDRLTAIYCIGSCVRKFPFSNLSTNQDSYDILVRISIQFIQLLQDNEKIIRNASVVQITKLATMFLNEMNQNMSPQKNCIRLFVQIMMTGTENQNRIQQTIRAIFQIALHFLANDNTLESCSSARLFDKTKMNIFIDEYSIWMDLIDELYLYCQQQQIIESKLHNITLEIFLKQSDDYICKQFEKIESELNHAKDLDDENTEFIYSDRSIRRKKFLQLFQRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP01</accession>
    <name>A0A922HP01_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP01"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="110" mass="13118" checksum="842CCE2EB7F9E474" modified="2023-02-22" version="1">MINKGQAHVYLIGYLFGFYVARTDRNYHGWMDLRYICWPIIIGGYLFCIYSPTPWIYGRPFNPIWSAILWPLNRIFWMNIAKQKLLPTDLKSTIVNDFKLINSHSTNNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPQ1</accession>
    <name>A0A922HPQ1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger CCHC domain-containing protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TRAMP-like complex RNA-binding factor ZCCHC7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZCCHC7</name>
        <name evidence="10" type="ORF">DERF_012515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPQ1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9501687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="314" mass="36928" checksum="02BAD75D0AFBB465" modified="2023-02-22" version="1">MAYDYLEEIPYDHGHMFQKTCENVSFLQNRNETSNDDDDDDQHELLIHNVRNIFNERKVVKKKKIKERKNLKRKNQTDLQQNTIDDDGQQSIVKQNKITPGQFDISYGHNISLNSDNCTDTKNGFYLEANYDNEDIDEVMKKLPKDRRYWKVGTQDLQSFFYRRGRHRPKQCNLCFNFGHLDRVCPNRIKRCFICGDDDHEQKSCDKKLTCSNCFMIGHTSKNCTSKIQCKLCNIVGHSQENCTYHWRKYLTVVNETDDHKDISIFQSNDVTINTKVSCYNCGMDGSHFGHECKSLTINRKRNEIPSPIFHLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPQ6</accession>
    <name>A0A922HPQ6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPQ6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="125" mass="13780" checksum="D92263A13704037B" modified="2023-02-22" version="1">MRWRHYNGLATIQFVWIGWFRNTNMIERHDSELILGRSENDEFDSLPFPIRSGPRPTLFSARTLNPSKRPFGSAGGRHDTFTCDMVISSNSIGPISPGKSSSVCTIVGLDLGPSPAGLNAEICIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPS7</accession>
    <name>A0A922HPS7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FMP27 GFWDK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPS7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1109" mass="128634" checksum="9C606ADD4CE2C735" modified="2023-02-22" version="1">MDLFYYPFYLLIFFIFGYFLSRIFLWLLNYYLRLKFQINLQVKSIRFNSLRTIQLACPSLGININIEHIGLSSKIFNSKYNSLFVLKFSDIRLEGDIAAAFLKLRSATLSINSDQAQSNDITFRQDDETTIQQLLRTFFINKLSILAKKTFYLGSNYVSSNFQVSLHNISLMQLGVPSRDYRINDCLLHSTIQLIQFGYAKSQNQITFQVDGFAIKMFKSQTSIVSTTNENDGGGKKSYLFQCSFPFRFVYSPGDRSAEMFISSCEIIVYDLLKLAKMAPKRMNRIEMGSLSKAKILDKLMMTFNTILKGSLFKSASFKLISATVKLVRESGKKELTFSVEPIELFLNKVDNHRLESDLSIANCILQDSESIIDFSLNKCKTLCTIERDKLTDKLYIQLILEIHNCSFIINIDYLINFWFQNYFVQLFHNDFNGKVNNPVDEYSHKEVAAKYINKFVFLMVIHDISLSLKHSENFGMVTYGLKHLKTTCVRNVDIFRETSVELLLETFWCWNGNIQLKPLNPNSLKKYNEKHVPLFMSTLLLKFGNMNSSDLRINCVMDGLQVSLEYFLNTLENFNLESLKNTISMKDGHNNISPTFHSPYNLLGQINFTSVNVFTRQLMMRIDSMACDLNGAKITTSINGFGVNSMYAPSATLACLKASELVQHRIVYFSVMRINFCQDNGQDVALSLTEEIFIQWCPLFHVNVLELWEDFYHIYLNFKPDIQSQSLSVTANNDDDLQIDTKPYSLSLKLDGKICLGILLSDDGDTMRFETEYFTIAYQNHNQSMTIKCELLNIFINDVLNCKVEHLLIGHLAAAKSYLDRRSFKLTEQEQNDAIEINVDKVTMKFPYQFNFAYYFNEKFLTIVKWLRLFHSKPKQSQPHSPSIDQKTLLSPDFIIKIQSILMELGDDPFEIRLNNNYELMEDEFNESLKRWNILMEKINEKSCGRNNAALLLTDELRRAFDRQNAKTYVERSNKMYDANQTVQRTQLFTIKMENFQLHLIADSSYDSYEKKIRLIKQIDFHSPFPEDLRFSTIWCRQLFASIGVCVISLRDFPQPMLNAKKLYFKGVLLGAEQEASARARRTCEIDMGPNFARFKIERSMTTMKFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HR66</accession>
    <name>A0A922HR66_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MRPS5</name>
        <name evidence="12" type="ORF">DERF_013896</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HR66"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048584">
        <property type="entry name" value="Ribosomal_uS5m_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21251">
        <property type="entry name" value="Ribosomal_uS5m_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="199"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9497966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="450" mass="51959" checksum="70866503EBBA789E" modified="2023-02-22" version="1">MFFFVTCSKLNLKKNSKMMLKIIQYSRHFVTNSLHLNSYQSILSTAKCFDLQNLASNHQQWRNSSSFFTRNSGEQIWKGLLSVSNAGRRRGREDKLWVSGEKHFLWPGLNAPVMKGSEIVQIKELKADPAYKENLIKIRDQMEKRKRAYVHPLERGWSGTKLLGKWIGPPDPIAGEEFLGFDTRLLVVRPVFYMKPNFGRTKTISVLAVTGNGNGLVGYAVAKSEDLRTAISNAKNKAGQRLFRVELDHDTILHDFYSRFGSTKVFAEKKPPGCGLSAHRCLRSICDVIGIKDINCKVEGSERNYLNLTRAFLLGLINQKTFQQMADEKRLNVVEINESFSNYPILKAKPSDNLGGCRTDEQIGDTEILDFDIFIHDGKVKEQQNLKPMYYTKEKGWRNYMKKWNYRKSREQVRINLMARYNGQLESYITIREKERLMAKRQKFLATQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS90</accession>
    <name>A0A922HS90_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphofurin acidic cluster sorting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PACS1</name>
        <name evidence="6" type="ORF">DERF_013946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PACS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS90"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019381">
        <property type="entry name" value="PACS1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057541">
        <property type="entry name" value="PACS1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280:SF17">
        <property type="entry name" value="KRUEPPEL TARGET AT 95D, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13280">
        <property type="entry name" value="PHOSPHOFURIN ACIDIC CLUSTER SORTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25332">
        <property type="entry name" value="C2_PACS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10254">
        <property type="entry name" value="Pacs-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 N-terminal C2" evidence="5">
        <location>
            <begin position="34"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofurin acidic cluster sorting protein 1/2 C-terminal" evidence="4">
        <location>
            <begin position="507"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="827"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1055"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1056"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9498019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1087" mass="124715" checksum="E42D64A1ABB9163B" modified="2023-02-22" version="1">MQKMADKTNTKQMSSSTMTATATTTMWSNNNKPVKMKLFGAWEIDKTPSDCIPRLCSLNITRLTLNKSLWTDATAIMVAVKMQNSKRILRSNEITIPSSTTNQSNDQQQQQQNQMLDIELDLSFTLQYPHFIKRNRNYLQIILQRRKKYKNKAILGYKTLACGLIDMVEVLQRSTINEKTLDLIGRVKDIGKNEIIARIMISSLKSQPIDNQDNSSGNLRRGKVSIDRPDVYSDDDDFTSAEDGSDSETIEEGNNVMFRRKLNHDHKSRKLFTTNDKFRSIVPTNVQQRNLKQKFISLLKKFRLPDSEAYDSEEKFQEALEKELMSSTQEPPEDIDEFFDDEEIDDLDYMTDSGQEFDDVSISSTPKPSLRPFFSSCTLVGQDKSYEFPIAEHNNNNSTNKLDESQETSGTDGTPETSDNSQKQMNLDLVDTLIVPSAHNKKKLSFDKETKRVKLFPRDKDNKNHHHNHREKEKKSLHATMSLLSTTTNYHHHKDDTAATNTSKEFVLDQLNKVFVEEPTATIPEEIIFINLTECMHNNQQEQQSFIQMFERTNYRIITTNTLNDIRLSFNFLCNRIQKYCNNNNNLKISTPIKLILIGSDPYINSFLRYYVESLANKSQEWQNFFRFFIIPINYLYHHGYHHPHHHYGSNMLHKYIASIDQTYSQYFFPSTTTTTTKSLTTKDYDSSRFINNTTITTTTIAENNQSSIDNNNNLQGIHEFYQKIVNFINNAQTVIQIPIAEAMVTYKDKNFDDESNQVFIPFICDVKIGLADHAGSHSMEEELFNFSTVGINLSSNSMLQQQSQPQVSTTQAMMMIDKSIITSPTFNSKDQQQQQQHISTPPNSPSMTATTTTANNQHVFNQLMNKESMMMNEVMDLQFDYWTASLQPRIVDISSSSAMASSSSSSSSSSNKKSDNCKFTLKNSFRHVQITRLPNFGEATCSSLTFSYITKEKKQKIMRLGKKKEKDVDGNKCPRQTIEGICRLVCSYKTSQSPIKLIIDGVEYSGVKFFQLTPQWQTQVKFFPIVIYSNNPPPLSSSLTTTTTTTSMIDKDIASSSSSSNHVMHQQQQHNNSQNDNYHHHRVLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSC9</accession>
    <name>A0A922HSC9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_011108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSC9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037412919" evidence="3">
        <location>
            <begin position="21"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="632"/>
        </location>
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            <begin position="256"/>
            <end position="279"/>
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            <begin position="280"/>
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            <begin position="517"/>
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            <begin position="561"/>
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            <begin position="606"/>
            <end position="632"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9506371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="632" mass="68740" checksum="86F21E375A8786B5" modified="2023-02-22" version="1">MIKFLLQLLPPIVVLIKAAATADDVNIDQNHSSLSNMTNEYTTMSTEIQNGHINNTPNRLRSQYQNLRKHPMINETCRDESSDILYIKQARADILDCCLQVLSCECINRHCQHDPIYVDGAFCKFTRSHPCQPRPYCVNLDVSYKKCMALPEVNRLLLIILIVFGSLIAFSILILICIIAYKKYKAYNKAKKHGGGTTSQPQLEMAIASSPNVTSQVMYVSSIQQPSQVNQTRKSNRKSRKNSSNARECSGGAGKSSSSSSSSSSKPSTCSSVSKPSTSDFVSSKSSQQPNNGQKFSKDAIKTADINIDQNQNHSSPSSSSILNITNVMNDSMTTIQNGHNMTNQTIFPTYSRLIYQNPNPDKFVYPLLNVTCFEERDSIIGVKEGRADILKCCSQELMCECFKRHCENDMNYKGGKFCKFLDTHQCHMTLDCQDLGITYEKCMALPNVNRWLLLVLIVLGAAVAFSILVLICMIAYKKFKAYNKVKKHGGGSQPTHLRMALAPRPNVTSHVMYTGASSQQPSSSSSSAAASSAAASQQASRNSKNSSVRVCSGGGGVGHGKSSSASSSSSTNYNRGSSNKPSTSLSSNRGGGGGGSSGSVSSASKQNSNYGHKFSKASSKPTRSFLQRAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSI5</accession>
    <name>A0A922HSI5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sco1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_012672</name>
        <name evidence="13" type="ORF">HUG17_8750</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2) by facilitating the incorporation of copper into the Cu(A) site of MT-CO2/COX2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSI5"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 8 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="116"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7637646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9501863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="292" mass="33645" checksum="BE4CCBCE7697CF03" modified="2023-02-22" version="1">MNLTILRSSHHLFRRLIHQNHGLSMKIFTSTRNFTALSSNNRSMIVRIKFNHHHSNHSSGTILWLSTGKSDESKRAFFTWKAFIISGVLVSLFAGFMIHLKNEKLKQMERQRKKALGETAVGGRFDLIDHNGKPYSSTNLEGRWAMIYFGFTHCPDVCPDELEKIVKAVELIEQDKHSDPILPVFITVDPERDNVQAVREYIHEFSPKFIGLTGNKEQINQATRAYRVYYSAGPRDHENDYIVDHTIITYLINPEGQLVDYYGQTKTAEDVAQGVMKAMKNYRNLNRKLGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTR5</accession>
    <name>A0A922HTR5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTR5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8106" checksum="9EF2E03F713666C2" modified="2023-02-22" version="1">MTTDSKIGEKNLWLCIKIFAGSSDSLYPNAQNRRMYEPCTKTTVTSVVGLKMSESIFYVYMQSIVEITEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTX1</accession>
    <name>A0A922HTX1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ALDH3A2_5</name>
        <name evidence="7" type="ORF">DERF_011849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTX1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9507151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="442" mass="50523" checksum="2F3976DBCB223F94" modified="2023-02-22" version="1">MTTMNESTIEMIVWKTRQTYCTDRTKNVQFRIKQLKQLRKCLTENYDQFMDALLADLDKSKPEATISEMRPLLNDIDYQLNNIYHHTRLQYTKTKHMTNIFDSTYIKYEPLGVVLIISPWNYPLILSIRPLIGAIVAGNCAILKPSELSPNTEKLLTELLPKYLDEECYRIVIGDADVSTRLLENRFDLIFFTGSPMIGRIVYNAASKFLTPCVMELGGKNPVYLDNNVTDFNESAKRILWAKCVNKGQTCIAPDYLICTKKVQDRFVRLIPEFLQQFYGSDASKSPFYGRIVNRKNFEHLKILLESTKEKIVIGGHIDVMTGFFPITIMANVTFNDPIMQKEIFGPILPIVTVDSLDEALALIKQNEKPLSINVFTNNDHVFERFQNETSSGSIVKNDLFFNLLVNELPFGGVGNSGFGNYFGPIFISNIFTCKKCHDKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUX8</accession>
    <name>A0A922HUX8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MPHOSPH10</name>
        <name evidence="9" type="ORF">DERF_011636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUX8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="562"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9506929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="663" mass="77476" checksum="B3C173D76DD978A2" modified="2023-02-22" version="1">MKLSKRKSSDSQPQNQKKIKSLIENEILKNFQQLSSNPDNFLLPNEDISLKFKTITKTLYDHGQKMMADLNISIKSIGKEKQSLKPLKNLLIDQFDDEQIWQQLELFNQSFIVHSVDDISKLLSNRMPITLNIDMTTDDNSTVNVNNVVVTKPILKPNEKTISIPKEKKCVKFQLIEPITTTIDKVKSTVNKVDFFDLNEMERYLDEQDEKEMQDNNHNEYDDDDDIEQIDHLYEFPSDNDDEDEENDDQETMYSDFFDPPSTANKRQQAMNFDDENDEEENEEDGDYQDDDIDLDTRDYDMNENDDDNDDEDDEINQQLKALANNEDDDSNIDGDPEKSEYEKSQLRLQQRIKKAEQELLLPSDLRWQFAGETNAGVRPSNSLLEEHVQFDHVSRPPPLITDETTANLETLIKQRIKDKVFDDVERKVKPKEQPFEFRRRIMLESEKSKIGLAEVYEQEYLKQQQKQKEQEIGATATALDAFVSIGEVEENETRKEIRRHIRLLFRKLDSLSAFHYTPRPPAPEVKILTNLPAVTVEEIVPDSVSDMKLLAPEEVFSTRDKKVLQDRGERTQTDKKRSRRLKKKKQSVKQRFIQSSKMKLNAHHHHADKRKLEIEAIEDGKSLKSSTKFFQRLQEKNELQKIQKKAKPIIIQQANLAKKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUZ1</accession>
    <name>A0A922HUZ1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUZ1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9502016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="84" mass="9233" checksum="E5FB4546520C3445" modified="2023-02-22" version="1">MSECSLISLRVTVVFDVDCDCVVDGDGDCFEFDLFDDDDDPLVLRFVTPKAANNEFGFGTFILRGIDVVGVVVDERSCCCCCCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV14</accession>
    <name>A0A922HV14_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cathepsin b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_010002</name>
        <name evidence="10" type="ORF">HUG17_0061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV14"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276916" evidence="8">
        <location>
            <begin position="29"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="107"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7644523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9511550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="363" mass="41581" checksum="30CAB6E94CA3CD47" modified="2023-02-22" version="1">MLRHHNRYRFMIGAILLVVQWSIHVCQSQEILEFEKRNHIPDDEFDFLSDDYIDFINKQLNTSWRAGRNFDSDASKIYIQGLMGTLPTPEHLKLPKLYHRIDDDERLPDEFDSRKKWPKCKTINEIRDQGPCGSCWAFGAAEAMSDRVCIGSNGRINVELSPEDLVSCCHDCGAGCNGGFPAAAWSYFVHNGLVSGGLYGNHHTCQPYVFAPCEHHMKGKRPPCSDIQPTPKCQNKCDKFYNHTYNDDKHYGRKAYSLTSNPEHIMKDIMVNGPVEADFSVYEDFLQYKSGVYQRHSHKFLGGHAIRILGWGIDANSKLPYWLCANSWNTDWGEAGFFRMLRGHNECDIEEDINAGIARISKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV45</accession>
    <name>A0A922HV45_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV45"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8691" checksum="94E26E959D9C0A43" modified="2023-02-22" version="1">MFVLQLEQIFCCCFANICDNRIACAGDSRLVEMLVLFEHDDDSQFSRYHFGYDYSNVFDNVIENHWETIQGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW01</accession>
    <name>A0A922HW01_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_011739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW01"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037939737" evidence="2">
        <location>
            <begin position="17"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9507035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="125" mass="14321" checksum="D5AB8508CE8465FA" modified="2023-02-22" version="1">MLRLFLFISIVSFMLAMVIVATVVDSTGCPPSSSAVKIVYKKIPYTIIKKVPIIKEVIKEVKVPVYIQHHDHHHGHHGHHGDGKHHHHHTIVAKKIKFHNNGHNGHQHHHHDDDDIKSYDSFGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX47</accession>
    <name>A0A922HX47_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dipeptidylpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DPP8</name>
        <name evidence="5" type="ORF">DERF_011434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX47"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF193">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="4">
        <location>
            <begin position="486"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="3">
        <location>
            <begin position="999"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9506717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1200" mass="138844" checksum="09F409A49136419B" modified="2023-02-22" version="1">MDKKLNSNNDGHHLDQNELINHQARQSIPIQRQYSPANSSQINLQLPSTSSRNNNRNNYHQNIPTNSSIPFIINEDSQQPPSANNYLSQSWKNALQMSALNMPSLPDYFTSVPMPSMPNITMPNLPSMPTLTMPSMPSMPNLSMPNISMPSMPNINFPSISDFMRKNIKSWEQICASVREARKKYTSICPSLPFDFNFGYDSKREKLRIYFLASINSLETTLYYCDVDLLKNSTTYTNEVLLDFIGDESDQADFPIDIEHKQQQQQEQNPQLLQNSSSSSSSYYQQKTNNEVRSRSNSETNIDIADCDLDLDNNASSGSPTSMTLSTQSLSSSNSNESYMNTSLLHKSISSPTSSISNLETIEWKPLITNLDELINLEPYTQQQTNNEKSTHETVQQSSTSSHEEDLILQRKRIILNGIFSYDFHPKMARFVFTMKNAIYWFDDIAINGANHLSEMKEQNNRSEVRNTTNLFPPYIPQKLINNDYIKLNATICPYKPDLVAYTADNDLWVCDLISGSEIRLTNTNYTKTAIMAGRPSFVMQEEFSRYIGFWWRPSYQIYQNVYTILCEFVDESVVERISISGWGSMDEVHRFPKPGSTNAKSTLKLVHFAFINSLGRSKDRQLRLLKIEDLHIRLESIYREYEYLTRCDWLNDDVIWAQLLNRQQNHMAIVLYSISNRFPPQIIHTESHRDHWYNCHEILYFLKNKPLENDKSDGNMIAIPNLTDNENDNGDGDYDVIMVGSKVEFLWSSEVTGFRHLYKISVEIANFPEKIQLDNDDSFVNDEKHIERMNQETRNQLSNHELKAELLENRQLTYGNWEVSESMYWVDEQNDLIFFLGTRDSPLENHLYVISSSQSSRIAPRRLSKEDFTHTKIVFDPKFRFCIDFQSNVSIPPFGYLHKVVAPVDNPLNINLEPQYMFLNLPDDIKVEDSMEYYEKVQILGPTPHLFECKLRSGELIYGFLFKPEFMEPGFKYPVLLEIYGGPEVQLVTKSFKDLRYHRRHLIASEGYVVVGFDSRGSKHRGVEFEKHIYKRLGQVEIDDQVEALQWLADNTGFIDMNRVAIHGWSFGGYLSLMALVKRPDIFKCAIAGAPVTNWLLYDTGYTERYMGLPSENAENYQRSSILSYIKHFPNEYNRLLIIHGLMDENVHFCHTAQLIQGLVMAGKPYQLSIYPYERHSLKKINSAEHFEATLIHYLQQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXP7</accession>
    <name>A0A922HXP7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrator complex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">INTS12</name>
        <name evidence="8" type="ORF">DERF_007207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Integrator subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXP7"/>
    <dbReference type="OrthoDB" id="5846437at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15501">
        <property type="entry name" value="PHD_Int12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039054">
        <property type="entry name" value="Int12_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="98"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9516471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="274" mass="30642" checksum="609900EC2198361D" modified="2023-02-22" version="1">MEIEDFIKGLRLLHSRSPESSDELKKLLDFYHAKKMNYNLESRKPKDSILNAFSSLQSLNQGIRGEDKKTKALEEDSETTDIEDNEMLDSNDASNIVNNQCIICKQGESNNRLLECQECRSCFHPECHKPIVPKKDINDPRSIWYCFKCKNTGRKLNKNAIVATNSGKVIIDPNKVVNAPKSTLDTMKRPNKIATTQSTPYHPILKAMSTTGTGMGNYVRQSSTVAIHANVTNKTKTSATIGSIHSAYNPSTTISNLDKRLANMKKTKSGLKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HY54</accession>
    <name>A0A922HY54_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HY54"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="453" mass="49409" checksum="6F0F43F0165250AE" modified="2023-02-22" version="1">MVEPTDSSLAFFQKASPNQWRFVYELRRDAIKLKADQRSSKKGGPEEFIKLDTWFREKLPQMIHSRKDPHVLYEELVQIAKWRLMMGKYRPKMLDLVRINTETSVVNITRKAFKKLQHQKNLQQAITQLVNLKGIGPSTASAVLAAAYPEEAPFMSDEGMLSTPGVEATDSTIAEFNNYSEQLRNKTESLRQSDPDYKWTPHKVDQVLWIYYLIKDYKPTLLDSMPRGDDTTSTINTDNVSQLSDAADDNANVMAPTTTTMIDADGDESSSQDVLLSHHLNESSLNGSLEDSESASVPYSEEDLSSQGAASCSVDSTAATIGSDVSAVCTMPSSLGSPPSIMITTSTPTPIIIGSQTMANGVNGNGNANGAAVINSNNNQTTTSNTHHLIMAVSLTPNMNINQQPRMLTPSEENSVDNSVGDDEVSLDEAPPMKKQKTGLDLVAAAEPTGAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ43</accession>
    <name>A0A922HZ43_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_009406</name>
        <name evidence="8" type="ORF">HUG17_7325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fl(2)d family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ43"/>
    <dbReference type="OrthoDB" id="3366661at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033757">
        <property type="entry name" value="WTAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING REGULATOR WTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15217">
        <property type="entry name" value="WILMS' TUMOR 1-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17098">
        <property type="entry name" value="Wtap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="79"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7637119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9510916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="322" mass="36710" checksum="01985FB61F869BF4" modified="2023-02-22" version="1">MISDETSNLSSIQPEESNSSLDKVDNNVINPLSNTNDEDEKKEQHDSRIADDDSSLDVLVVESKLCPEMNPESNDSVSKKEMEAIRNSYENKLKKQQLESTRKENILIMRLTLKDQELQECLAQIEALKELERPSISNAESLHLDPAFNYIFEKMKKEVDVSKSRVEEMQNDMKAWKFTADSAHGKQLMAKCRSLHDENEELGKMISSGKIAKLESGLAMHKNYSEALNKSQSEVEEVVNEIEETVEGFQNTIYYLQQQLKHCKDRCHQLEQIIHNCNGHCKNQLVLDTATNDNGNDDGQQQIQTSLQITTQIELNGCVNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZE7</accession>
    <name>A0A922HZE7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar protein 58</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nucleolar protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">TCP1-chaperonin cofactor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Tubulin-folding cofactor A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Tubulin-specific chaperone A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NOP58</name>
        <name evidence="19" type="ORF">DERF_006882</name>
        <name evidence="18" type="ORF">HUG17_1424</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs).</text>
    </comment>
    <comment type="function">
        <text evidence="1">Tubulin-folding protein; involved in the early step of the tubulin folding pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles; the core proteins SNU13, NOP56, NOP58 and FBL or FBLL1 assemble stepwise onto the snoRNA. Interacts with NOLC1/Nopp140. Interacts with NOPCHAP1, NUFIP1, RUVBL1 and RUVBL2; NOPCHAP1 bridges the association of NOP58 with RUVBL1:RUVBL2 and NUFIP1. Interacts with PIH1D1. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TBCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZE7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000004">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="17">
        <location>
            <begin position="284"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="440"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7645886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9516120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="594" mass="67142" checksum="848DC0E40AEEE6E4" modified="2023-02-22" version="1">MLVLLESASGFYIFKVNDESKLNQPANLYKEFENAKKATKLLSFEVNQKFKDATDALTSTTALIEGKLSKRLKKFLSKKVLSVYSDETLAVADAKLAGAIKEKLDVPCVTSNAIQELMSCIRIHLPELVPDWNEDEEAAMQLGLSHGLGRYKLKFSPDKVDTMIIQAISLLDDLDKELNNYIMRAKEWYGWHFPELSKIIADNIAYIRTVMTIGMRTNAVTTDLSEIIPEEVETQVKELAEVSMGTEIAGEDLINIHALCRNCLDLHEYRAQLLEYLKNRMMAVAPNLTILVGELVGARLISHAGSLLNLAKHPASTVQILGAEKALFRALKTKHDTPKYGLIYHAQLITQANSKLKGKMSRMLAAKAALAIRVDALGEESSNELGVQNRAKLETQLKFFEEGNIRRISATGRQQRSQHPQKFENKSKVMIYKDGADSTFVPKNKRKSFDQDDVDDEAKPSPAKETNEQEEEVGEKTMDDDQDHQQVTSAKKKKKNKKIKKESDECVKERQAYEQELTRETERLNTMREQQRDVYEINKQQEIINETAMLLPDCQKRITAAYHDLQQLVEGVGDYAENEIYSAAKALLQETNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZS5</accession>
    <name>A0A922HZS5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein alan shepard</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RBMS1</name>
        <name evidence="8" type="ORF">DERF_006782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Has a role in the perception of gravity.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZS5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12243">
        <property type="entry name" value="RRM1_MSSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12244">
        <property type="entry name" value="RRM2_MSSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000169">
        <property type="entry name" value="protein alan shepard isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000012">
        <property type="entry name" value="RNA-binding motif, single-stranded-interacting protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="416"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="510"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="723"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="746"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9516017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="789" mass="84859" checksum="2717D7150E276DAE" modified="2023-02-22" version="1">MINPTAMAAAMMNPFTGFTGAPPPPTHNASVATNNNSNNNHHHHRQHHHGSINSGQQQHPHQHHHSSSSSSSTTTAAATLSSSSSSTIHHQTSSSHGNYVNYYTSNADGIRQYYPPPSTIPPVHSNAQSHSGHTQESQPKILYSRALQGSMSNTTSSTTSTTNNIKTMSSGNNNNNINQQQSKTTLVVSPSSTTITTTSSILANSMVDMNGPNMSSYHQHSPHLPHLNNNKRHNDSDKVQQIGTSGGSSVVVGIGGNGRTILPNSSQQTNMPFRMSNKNCLQQSSSNNNYSIRHTQPYHNSRISSQQQQQQITSSVSPSTTSAVSAAAAAAVGTGNQMVQTNNKLSTNGSSTSINVPSINSGNNANNNSTTSGNNNNNSSLSMNSTTNVNTQNGTTASILSSDKSDSSTLTTISKTNLYIRGLTPNTTDKDLQLLCQPYGNIVSTKAILDKETNKCKGYGFVDFDNPNSAEQAVKSLISQGVQAQMAKCTDTNRNKTMQQKILQQEHDPTNLYIANLPMTMAETDLEAMLSLYGNVISTRILKDSNGTPRGVGFARMESKEKCESIINILNGKLLPGGKDTLLVKFADGGSKKKNHYKNESRYRSDVDQLQMGFDSTNLTTNGGVTAMLPSPLSATSYQRFSSPYQNPMQANPWMHHQAPQPQYIMQPQLMDPNAATALQFSPALMHQLTAQMSHIQLGGVSGTAGYHLPGNPHPYGTQLYTPQLIPTMPMSGVSGDQQQDPINPSQSVSSGSVSGEDPQQHQQQSNPQQTSQQAPPPPNFQLCYGQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0S6</accession>
    <name>A0A922I0S6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0S6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="7101" checksum="6B4CF3112812A14E" modified="2023-02-22" version="1">MNAELNRAFIIFVFEYDKLKQNFGQTTETKQKKIHNEKIVFLRPHEYMIKTDVDVLVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I106</accession>
    <name>A0A922I106_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I106"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29824" checksum="817FBCEBF56AF5CE" modified="2023-02-22" version="1">MQAYADDIAIIVSSKCQTYLPIKINNVLKLAYEWGAKCKLTFSEAKTQVMFVTRRINRPIYSPVIMNGIEIKPVEQMKILGVIFDHRLDYRPHIHYAVSKAVKVYRAVNSIARKTYGLGPRVLQLIHHCIIEPIITYGAVVTRRAVQYQHVIKELRQMLKPMAQKATMAYRTAPIIATSAIADFPLIDLLINYRATVVNARVTKLYSHLDSDIPVDIEEVRETSADVRINFILREPAVFPPIRIFMKSILTNHGIGTAFYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1W2</accession>
    <name>A0A922I1W2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_004647</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1W2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9520972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="476" mass="56024" checksum="27F8AFE9BBD573E7" modified="2023-02-22" version="1">MNSVNNRRQTDDSVELSTLNHGSNNHSAMISNGNNRSDFQIISSQLHPHHNYHDSQLPQVFIIQQQQQQQQHQQSEQRQQQNSSYDQRLKFGLNFRTIIILIVAIIIASIAIRSLYKSFRCDPNHYRYRYSGSNGHPVHSVFRIAENRRYVIEDGVPSSSSSSSPWWNIGSWCPPPNDRQELVANPFELAAVSLTLKNLTEKNIIKLLNSTSGSNDRDCQAQLGSSLERMQQVCKQYRLNNHLLSPWHSTTPESCKTTRLCPLMIDNSTKIMACFLPRVFEPEWFQKSFAYQYDHPQLMSMIQQAQLVNNTSYIRIMFVRHPFVRLVDAFKKRFELAEFLPDGRPLIINNETMHVWTFEEWCEELLLPIDPYQYDPLWAPIWTQCEPCYVRYDLVGHYETFYQDFQNARQLFTNHSDISDNKNVDIPIVNDRDCDKRSYQETQQYIRRLKPKTIMALYAKYYLDFELFGYTIDEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2V9</accession>
    <name>A0A922I2V9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_008277</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2V9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08554">
        <property type="entry name" value="Cyt_b561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF0">
        <property type="entry name" value="LD36721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="102"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9517622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="388" mass="44181" checksum="FBA1DD959FBF487B" modified="2023-02-22" version="1">MSPPNSPPSSSPPPPSPSSPAQEDDNEAIVTVTDTTTEPPIKSSLDLNSSRKRKRKKSASPSRRQTIRSTPIEKIKIRAKINQENNNHVDATDGLNCLLYFLAQFFALIILSLLACWLIEYFGGFSLIPNDNDGDGYNYVDRIINFHPLIMTFSMIFTLANSILFINSSKKLTNARLFLIVMTFLIGFIGSGITIYWHFKMNYPHLQSMHSWFGILTWLMICFYISYIIYVYDNNQDLNERQRTDMVFAVRLFGIATLIIAGTTCLLGLNQLLSMTNIVTKNSTTLESSEIESLMMINNSSSIELNAATKLRSQANLLANSIAMFMILYILIMMYIIVRLRYKPRGNVRRQRMERQIRQTIERAMLTIDPEDETRSNNNSPPLFSPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2Y3</accession>
    <name>A0A922I2Y3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger CCHC domain-containing protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ZCCHC9</name>
        <name evidence="4" type="ORF">DERF_007190</name>
        <name evidence="3" type="ORF">HUG17_1643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2Y3"/>
    <dbReference type="OrthoDB" id="3863715at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042246">
        <property type="entry name" value="ZCCHC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 ZCCHC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7646105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9516455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="265" mass="30714" checksum="5A772AF03AC5D15B" modified="2023-02-22" version="1">MANKKGKKLNSTRSNVFKCTLMSTSDETTKKNIEYKKSTDRIIKSKRTNNFYMKCAKNRQDKGLVILPRNVETKIYKLKKILQRKNIDPDEIKQIIRKKRRDEENRLRHDIKRVCFKCRQPGHLVSDCPLQSDPDELTNICYFCCSLEHKLSECTKYQKKMKQLSSDDVNDVSLPFAKCFVCHQNGHLTRNCSMNKNGAFPRGGKCRGCGSINHTLKECPKKKTNVEEEEILLSTFNNMDCGVDVDEFSLEKLITQTGEKKIVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I342</accession>
    <name>A0A922I342_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_008295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I342"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="361"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9517643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="575" mass="64615" checksum="79CF768952F5109F" modified="2023-02-22" version="1">MDVLLKRGYTNLVKIDSGGQARVYKAEHVPDGKLVAIKIIHVENPNNTKLDDDLKRELQIISNVQHPNCIKVHKLLRSQGKVYIVMDYMINGTIGSRIRNDGELCEWHARLWFCPIARAIKYLHEHRIAHRDLKLDNILLDSHWNPILTDFGFSRFVNIMDDGQIQKSNTYCGTPSYNPPEVLKQIPYNPFAADIWCMGIMLFIMINKIYPFDKNDREKMYECQISRRYKLRDQIEMKSSIDVKDLIDRLLEPNPDLRPTIHDVCNHPWFPIVLRENEFIRKQRTTTATGDQQRPSSPDPQQQQQQSIDMTKSPGIDGAVRNTSTRIVGFVFPHQRFHFHLKIDRYNNDNDMPIVPSDRRNRVFIGGIGDRITKEDIETEFGRFGKLTNVWVAQNPPGFAFVEYDHISEADLAVSEMNGKSFLGSTNKIRVEHSHGGKSRNGRRGPGGGRFDGPRSSFGGGGGPPRNFSGGDGGYRSNGGGYRRMGRDGAFSGGSGRFDNGDKRRPFQSGGGGGGGRFSSGGGPRYGRNDRPYGGGGGRRSRSPNGRSNKYPPRVEPMSQGFSPVGGGYGNPSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I376</accession>
    <name>A0A922I376_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRPL12</name>
        <name evidence="6" type="ORF">DERF_007324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I376"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="54"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="120"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9516590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="188" mass="20328" checksum="99971F21E0A80D35" modified="2023-02-22" version="1">MFTMKILSITSRLNRQFISNRTMHVGRSLCSAQAASQSVVDGNQILSPTETSPKIKAIVDEIGKLTLLEVAELNVALKEVLKIPDAPMMSFAAGAMMAGMPGDKADEETDTASKTVQTSFNLKITKFDEGKKVALIKEVKNLVEGLNLVQAKKFVESVPQVVKNNLSKEEAEKLKTTLEAVGATCSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I383</accession>
    <name>A0A922I383_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-coumarate--CoA ligase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">4CL1_2</name>
        <name evidence="7" type="ORF">DERF_008344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I383"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="452"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9517703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="547" mass="62176" checksum="6D31293A10C77D38" modified="2023-02-22" version="1">MSKSIDKNLKTIGEYLFKNGQISTRLKDQIFLTEAKSGKQLKYGQLEDQSHSLAIAMLREFDFQSNDICAIMSESCIEYTIIINACLLLNVPYTSVAPVIGPFFIGERLDQTKSKCLFISNEYYFKLEQMYRQSKWQHLRDYVKIVVINYDQTFDDDKQYNSTTIKFDELISKFKNEKISTIPYYGNNESSIDDLVTIIFTSGSTGRPKGACHTHRTLLTNVIEMKSVETLAKYSHQTMLLTFPLGHVSGNCLLFVALISQTPIVLLNYNEMDRIFDVIEKYRCVQVFGSANIVNLLAKSDLTSHRDISSVKMVLTAGCKLSTSTAEILAKKHGIQILDAYGCTECLYISIGVSSQNVGKPLPSFQLKLIDNLTKNELTNSSSEQLGEICIRGTSRFREYYGRPDETKKAIDNDGWFHTGDVGFIDNNGCLHITDRIKEIIKYKGWSVFPAEIELFLMTHDDVIGVVVVGVKHNEYNEVPRAYVTVKSESSITVEQLQQYVNDNLGYHQRLIGGLLIVDQLHYNQMGKIDRRFYKDLCANEILDNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3U4</accession>
    <name>A0A922I3U4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3U4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33205:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="325" mass="37597" checksum="EFC43B2EE3F11FF9" modified="2023-02-22" version="1">METDLLAPQFYTTQCKQQLIDIVETAFRIQRHVKTGLETSISNHRQTQFIYSRRRTFINQFIRRRFRPETITPSNQRLDGHLSPAQSYGRPNHLIERGLASSARNAPKLVAEKNKGTISEKIHFRCRWLQALIESTEAQTSWFHLFAFQWFHVLFNSLFKVLCNFPSRYLFAIGLAVIFSLGWSLPPTLSCTLKQPDSRMHRDECATKPSNNHQRSQHSKCLEIISRHRNESRRYRFITFGLSNFDNDAQTNEAIGYPMAAMCVRMSSDQSVLHFTPINVASYVLPRPASRQSNYARIWYLNLAALITSDTLHPRSSRGQTGTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3V2</accession>
    <name>A0A922I3V2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3V2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="104" mass="12494" checksum="9001D495C723B61E" modified="2023-02-22" version="1" fragment="single">MKSILKNNQLDNFDGSKEQKQQQQQQQRKKQKQQQQQQQRIKANQNGEKKMVLFLQDKKLEIFRNNLNHYDDAPYRANNDDNNVHGDKLFGIMKQQRQHLCKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I416</accession>
    <name>A0A922I416_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Duf1168 domain containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">PRKR-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PRKRIP1</name>
        <name evidence="3" type="ORF">DERF_004791</name>
        <name evidence="2" type="ORF">HUG17_7745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I416"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7640278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9521117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="162" mass="18713" checksum="814A61E65FAD8C7E" modified="2023-02-22" version="1">MSDDDNDEGGKKFHPFTATDVQKIRLEKLMANIDKPIEIPTGLKTKNFATPPEFVRNVMGSSAGAGSGEFHVYRHLRRKEYARLNFIETQAKNEQLDESYRQKIEENRRKAEEATAKKRAKRLKKKEKLKAKKKMRKNEDNDKPNSEDDNQDDNGNNTDSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4Q2</accession>
    <name>A0A922I4Q2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004829</name>
        <name evidence="1" type="ORF">HUG17_7770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4Q2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7640303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="157" mass="18530" checksum="97E6B29BFA44FA1D" modified="2023-02-22" version="1">MDEDLKKRVQALCRQPPKPIDNGDDEDDDDLDTLTDWPLLNNWLQTMQEFNVIIPKLQQNIQSQEMDVTFNISVLSFLNDSLDRSIKTSSNATSITDKYFSMDRDFHTIAGIVEDLKNFDHKRLQQILDNDEKLVFERLTKKLETYLDKLNMKYKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4Q4</accession>
    <name>A0A922I4Q4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <shortName evidence="11">DHOdehase</shortName>
            <ecNumber evidence="4 11">1.3.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_004942</name>
        <name evidence="13" type="ORF">HUG17_7844</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="11">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="4 11"/>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4Q4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009220">
        <property type="term" value="P:pyrimidine ribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003645">
        <property type="entry name" value="PRK05286.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003652">
        <property type="entry name" value="PRK05286.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11" id="KW-0288">FMN</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="76"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7640377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9521270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="407" mass="45778" checksum="F8A5195FC56A0175" modified="2023-02-22" version="1">MSKKLKSLVTVGLGATVCFYGYNLYHGDYRLWSRHVIPIIHLMYPDAEKSHIVAITAARVGLVPRIPEDKDIKPILKTKLWNIEFDNPVGLAAGFDKNGEAIKSLSGFGFGFLEIGTVTPEPQKGNFLPRVFRLSKDRAVINRYGFNNYGHDRMETNLSRQESIIDKQNIIVGLNLGANKLTEDKIQDYIIGLQRFHVKNEIKYFVINISSPNTPNLRNLEGKDQLNKLLDRVLRVKKELEQKNQLHKPLLVKFSPDLNDDQINDIGKIMLKYSNETQTHGQIDGMIISNTTITRPADLKSPARLVKEEGGLSGPPLRKLSTEMIRKMYRLTNGSIPIIGVGGIETGLDAYEKIKAGASMVQLYTSMIYFGPPIVREVKYELAYMLAKDGFKNVNDAIGADFKSLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4Q8</accession>
    <name>A0A922I4Q8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4Q8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="43" mass="5049" checksum="7E3186B89F3F2AA2" modified="2023-02-22" version="1">MIKSSSSSSKPYWIYENVSILGVDVGYNKSMVIHYDHLLYIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I520</accession>
    <name>A0A922I520_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_005293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I520"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9521657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="208" mass="24133" checksum="42187BBC35B93E77" modified="2023-02-22" version="1">MYVMMAFYYLSLFMAIIAIQFFIVYVNCYYQQHYGSPKSFGYKTEIHHPARSYVYHEQHFPKISKSYYDNDNYGPNRHGGHKYNFDDDGGFKFDHYSPPMKRQIITYHHQAPPPPPPPKKTEKENDSIKFSVDIPVKNMDFGKGLEKEIMSVHEGITKSDDNGMVENNYGNDNSYGGVGDEKEMKKDLSIPEISIPKFDVDGMLDKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I640</accession>
    <name>A0A922I640_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_006401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I640"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14103">
        <property type="entry name" value="STKc_MLCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000594">
        <property type="entry name" value="Myosin light chain kinase isoform-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF20">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="34"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9522844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="360" mass="40942" checksum="12BB75CCDFEE8CD9" modified="2023-02-22" version="1">MIYVDETDPIDENEEPPFQPRNVCVKKINPNVEYTLGEELGRGKFGVVRLCYEKQSKKKLAAKFIQTTCTQDRKDVEREVEIMCALQHPRLLQLYDAFDDGKNQMCLIMECVEGGELFERVIDDDFVLTEKACSIFVRQICEGLDYIHSKSIIHLDMKPENVLCVTRTGNRIKLIDFGFARKFNKGLQVMFGTPEFAAPEVINFEDVDFVTDLWAVGVITYVLLSGLSPFMGDSDLETMANVTRAVYDFNDESFDPISKGAKDFIAKLLVKDKTKRLTATQALKHPWLKTRTKKLKNEPKDKSLDKKKLKKFVIRRRWQKAVNAILALRRMGATIDLPPLPIASIPTPKKSAPKTGKAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I667</accession>
    <name>A0A922I667_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I667"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="177" mass="20261" checksum="BE96AA6B864C0852" modified="2023-02-22" version="1">MTQKQNMVEDENDNREEFILIRAPKTIDPSTLNGPKIYLNRTDDCRPNVIRSSSSSSCIDDNNQTYGYNFTAIDGNDLPFYYSMNKIQPEKSGDNACYRMDRDSRLKGCLNFYKQSSSSNQESNECELQPLDSSTCDGPNDPVEMIIHRNKRKSTMTITTTITESKQVRKKSKLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I694</accession>
    <name>A0A922I694_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ELM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_005647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I694"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELM2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9522043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="193" mass="23196" checksum="87705FEF55F42793" modified="2023-02-22" version="1">MPRISVVNKDTAKEKNWITDIPNYEPPPIIDYKEPTYNHNNDQLVWIPNLVDDNELDEFIAVAKETNDWTLDQSHCFLHAFDYDIKKALKNLAIFRTVRSKPFDRCQQISMQHMMIHDNRIKTNRFPNHYELVKFLICDNHESLIRKDIISEILKSEIEYDEILKREQAIRELAQKQQQMIKNKKKMRKIKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6L0</accession>
    <name>A0A922I6L0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6L0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="8095" checksum="A63A96FA5CC18767" modified="2023-02-22" version="1">MDYKTFVSNLSLMKKKQLRLMVPWLLIGHDDSIYTFDFDSIECGIYHSFTIVHSRTFKQPIHPEKYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7B9</accession>
    <name>A0A922I7B9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_004434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7B9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="4">
        <location>
            <begin position="90"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="5">
        <location>
            <begin position="493"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9520743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="549" mass="60880" checksum="DC1F8E09BE5EE630" modified="2023-02-22" version="1">MTSSTLNLDKIYTVLLTLCRYRSICHSLSLIAVRTANKIERQQLQHQIRKYSAYNKIFAFHREKRLEQIDQLQTRKMSDYREEKDTMGIVRVPADRLYGAQTQRSRDNFRIGAGQNWDVEQMPKQIIHAFAVLKKACARVNQSYGELDEKLAKAIQQACDDVIDERLSIKDEFPLVIWQTGSGTQSNMNCNEVIANRASEILGGKRGAERLVHPNDHVNKSQSSNDTYPTAMHIAAAVEVNKVLLPALEKLHQSLMAKQNEFAKIIKIGRTHLQDATPLTLGQEFSGYSAQVQFGIDRVKAALEPRVYYLAIGGTAVGTGLNTRESWDRDVCKQISEITGLNFRPAPNKFEALASHDAMVELSGSLNVLACSLNKIANDIRLLASGPRSGIGELLLPELEPGSSIMPGKVNPTQCEAMTMVCAQVQGNHVATTIGGTQGHFELNVFKPMMAANVLRSSRLLADASVSFTKNCVDGIQANEKRIEQLMRDSLMLVTALNPHIGYDNAAKIAKTAHKEGGNLKDTAIKLGLLTAEQFDQWVRPENMIGPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7E0</accession>
    <name>A0A922I7E0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7E0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="572"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="774"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="830"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="879"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="895" mass="103496" checksum="E8E78359E11E8967" modified="2023-02-22" version="1">MSSTCCACHHHTNHHINGSNTLPSNSSFSDSIGSYNNNNNNNNNNNNGNHQHTINVVTCKSSSSSSNTIDHHHHHQQHNHHHHHHNNMVSSNNDCGYCCFRPARWLFTLLSSWAHRTNRHLSLITLSFVFILIWSSILSSIMIIHSYRERESATNMIELFTMHKNVGQLAFAIGNEMLSTLKLNKQQQQMMNNTTNNDQLNHTNTSSLYQQQNETDMAVKQMLNALKQKGYNGDQIEAMINEKLHYLRSKCNNWSINSSNNEIVTNSTIHHRNQTKQSSSMMIDCVRTYEKFFYNLDMELLPVYHHQQQSQSQQQNQSWLWERYSKLAMTDFSLRNMPYTLFIRGVIQRYTALGFGTILLATADFNNQKSIMKTFNISDYFHYYYSSRQQIESSFVWNQKFYQKYLEFEQSEYQTEMLVNHFNRWLMDIQQQYSQMSQLMIRLFTQETLNRMHSYLKKKNAESIERLMFVNGNRTKFITDQDANNQISIHVDSDFIESFGLQRIQHLINMAPQQPQQQQKSSTIDDVNNVMNEQYEQLTKDQVRFLIRVQDFLNISMYSHLVQTMINEQTNFIYHSIVVTMLIISVVSGLILFIYICIWSSYFRHPSCCMMMKSTNHHHHHHSGIFNRRWFIRRRPFWNLSLPSTSTFKTYFSSTATNQQHSSGCHHCHHHHHHHQSLNHRSCRSSLTNHHHNYCGPMTCCCCCCFQMIMNPGSPTINNGRLLKKNHCHHTSTLANVIFPCSNSNNAFLISSSTKRTIAGAVINRYCATPISSSSSSNNHQNQSINHNTNNNNQTKTSLSTYKFDNTRNNHGSGKNAINNGDTVAPIGPSLSSSSTTSTNSNHQIDCSIKHEKLSSIAEKNSECPKQKNNGIDDDDDNGNGNLAENNGCNDNNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7I4</accession>
    <name>A0A922I7I4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HAT1</name>
        <name evidence="12" type="ORF">DERF_000509</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7I4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048776">
        <property type="entry name" value="HAT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21183">
        <property type="entry name" value="HAT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Histone acetyltransferase type B catalytic subunit C-terminal" evidence="11">
        <location>
            <begin position="314"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="391"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9526411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="449" mass="53375" checksum="2B125B10D9738B33" modified="2023-02-22" version="1">MNDIMSFEFNAFENYVTDSNECVRFKLVTCIDDLIEDFDDTKVLGHKQDGESKKLVSSSCRIAPFKPDMTYQFFGENENIFGYKDLTVKVYYSCAQLNIYLCLKYADRLTKQQTDGIEPDDVLKIIASKYETKVCYNLNEFSANLSKEQSFMPYGELMEEFEIETKPTDDHQQAQKRHFCLFKANNSVPGFVAYHERMQTFLMWFIEGASYIEIDDDHWDFFVLYEKLPFIGSQSSKPLLKEYQYCFVGYSTVYRYYAYPQNVRPRISQFLILPSFQRIGLGSKLLASIYTNYNNKSIVDITVEDPSDDFQRMRDIYDCKLSIQLNWYKTLAPNTVWSNEMAREAQMKFKLNPKQTRRVFEILKLKLTNRNDPEQYRQYRMGIKQRLNAPYKKQINDIERLRQRKAISETNYTLLMKTNQIPREYRIKNLNKQYEEIESEYLQIIEKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7I5</accession>
    <name>A0A922I7I5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7I5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9784" checksum="AF0FAB74725167F1" modified="2023-02-22" version="1">MKSHNDKFDIRCKNPSQMILNRAGNVAFRASIATQTTKTSSNRVFIPSAIILTITGFGVSLFGLHRLDNSRKHSFYLNTNKQWKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8F2</accession>
    <name>A0A922I8F2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8F2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="7376" checksum="285E309D8CCD7CF0" modified="2023-02-22" version="1">MNEIVSQSARAIVYRPVYRFFIFLMNHHTHFHFNYITCDEKFTVAKTKLITMSQTCTSRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8H6</accession>
    <name>A0A922I8H6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8H6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7738" checksum="CA3BC8F2709B5DF9" modified="2023-02-22" version="1">MNRDDTDLFHFGLSNFDNDAQTNEAIGYPMAAMCVRMSSDQSVLHFTPINVASYVLPRPASRVIHHWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I923</accession>
    <name>A0A922I923_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sphingomyelin phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SMPD1_1</name>
        <name evidence="14" type="ORF">DERF_001227</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I923"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061750">
        <property type="term" value="F:acid sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045473">
        <property type="entry name" value="ASM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19272">
        <property type="entry name" value="ASMase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="12">
        <location>
            <begin position="393"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingomyelin phosphodiesterase C-terminal" evidence="13">
        <location>
            <begin position="684"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9527191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="811" mass="93148" checksum="90C498B41B0FE0DD" modified="2023-02-22" version="1">MLISIDSGANSIDMRFIMRYDGTRNIFIYSMFTTIIIIMVWYSCMIVEANTVSGVSSRYSSSSLSKPQSSSSSQSSSLIISGGNNNQRSEVRKFPILRALVSQFVSDRSSRDMINKDDSEILLGSFESSSSYSTPTFQSQRIKDNGKSLSSSSSSSSSIVAANQSPTINKQQQQQQQQQQQQQQSSQLKLHKQHVNSSNVKSIQHIIDDINSQNSKISNKRRKRFLVNILSRMLKSVNFTELSSQMRNGISSRASCWACNALAGLFLSPVYSKEMMTMAVNTVCMSFRLQTPRVCSGIVDSFKDDLDYIRTHTTLKHGEMCGVIFGMDCARKVTKNLNWTITIPERKHYRYFSNNNVKRTDNNIGNTDTVTGIENEFITVMDSYKDSYKSISKLVQITDIHVDPYYEPGSEASCGEPLCCRSTNGLAKNKDRSAGIWGDYRNCDTPVQTLRHVLKHINEMHSDAEYWLWTGDVAPHDIWNVTKHEVISQMKLVTNLIKQYARVPVYPVIGNHEGVPVNSFPPPEIKGSNSISWLYDSVAEEWAFWLPDDALQTLRYGGYYMVKPRSNMRVICINTNYCARLNPWSLYNPVDPANQLKWLSEELHKAEKVGDKVHIIGHIPPDNRECTQAWLYNFLRIIDRFNDTVLAQYYGHTHRDEYRLFYSPGHHEVPIGLAYIGPSITPFTENNPAYRLYYMEDSGLLTDHETYYFNLTEANHSNRGPQWKHEYRAIEKFGLDDMSPDSWHNLSIKLHTDDKLFNEFKNLYYRHSDVKKDERCTDKCRKYILSDLAVLHPLKNRPKRFFGRRKHSHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9H3</accession>
    <name>A0A922I9H3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sequence-specific DNA binding transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NFAT5</name>
        <name evidence="9" type="ORF">DERF_001433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Immunoglobulins"/>
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        <property type="entry name" value="RHD_dimer"/>
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    </dbReference>
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    </dbReference>
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            <end position="222"/>
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            <begin position="539"/>
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            <begin position="1"/>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9J4</accession>
    <name>A0A922I9J4_DERFA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001461</name>
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    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
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            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
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    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="1">Derf</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <position position="131"/>
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    <sequence length="131" mass="15413" checksum="7F6183AEA205D315" modified="2023-02-22" version="1" fragment="single">HPSISTVGTAAAEAAVTDKTNGPFKITFWMDVEGPSQKRYFIFNSHIDSNDVSNREKKSLFYFIYFVDHHQFIYPNIVRRWLVKCSRRRRRRIIPFDDARSLLLHSAFDVTTVKTYNLLYCIVRLTANCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9T0</accession>
    <name>A0A922I9T0_DERFA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
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            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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            <taxon>Dermatophagoides</taxon>
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    <reference evidence="2" key="1">
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                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
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            <end position="423"/>
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            <begin position="436"/>
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            <end position="478"/>
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        </location>
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            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="639" mass="69625" checksum="88B19DB017A4A9A2" modified="2023-02-22" version="1">MLSTQGVDLIVKTTTATTISATAASDHRHQRPLYNISNSNNHPHEHSYSHKFNRTDNQLSSYHQIPENFETYSDLNHTATDEQFQQEDLLIEQEESLFIPCTDTLEFDDLEKTMSNSTQVSAPPVQFLQSNTFGGLVMSGPGSNVVGQVNEAIMDHHHHGLSHHHQLWGHSDFANGVSSTTANNNGGGATNSTAQTMMIDENNGAITIISNGHHHHHNTPELHELTPTDLSKYLDDDDLMGPSSNLSDTVMNGVHGSSAMNNAFVCDLDSLLDDLHADSTHLLLTNPEKLLSQHNDGTTSTTNNNNASSNTNSSSSSSPPSQQLQHLNLNLNNNSNNDQIEILSTTRATNNNQTILLSTLLSSASSSNSSSTSTSSPTPTSNGNDDDNTTTIITNIDLDIPNSYKTNENPCSSTNNTANSNNSMVETNNSIVIVSSPTSTSAQPQFGSQQQQQQQSSKSNLATTSVSATTTTTTMSRTINSNYSLPLARKSQTVNEKPQHRRISIETREHLGKPIFSSSSRSSNRQSSQQRQVTKQQSQPLPDSTTPTPCSSNTTNKLTDGGSILQNALLQPRSTSSSTTSSISSQNSNSTTSNKSNNNSISEHFYNLMQRQQQQQRQQQQQQQQQQQQLISSKNNSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9X3</accession>
    <name>A0A922I9X3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9X3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="618" mass="66488" checksum="CE4CC699F6F7A3B5" modified="2023-02-22" version="1">MLMSPKPEPVATTHHHIDHRTAATMGTTSLELNQSKYNSINGFHHCNGDDYCHRLNPVATTTTTTPMSTPTQSPLQSQQQQQQQQQQQTSFASDMNDLNDELDDDDDCDDSGDDITEEEEQDENETRNHNNNSSGGNDKNNTSISTTSIPTTSSISTTSTTTTGNNNNPASSIFYTAMTCYTNPDIGSNKDQTNSYHHHPTSGGSGAGDHYLPLSSSYHPSISIDQQPYQLANSTSTSTSSLNRYNGQSSFNNVDDNSNMLHNGGGGGGGIVESETFYHERRRYHFLPHSNSNSSSSSSSVSSSTNSNLDSNNSSSNGSSSSSSSSVANNALVPVTGENSNQLQSSSTTTQMTDLVNNPFGAITPSGGGHHTTVMQSSIINQSNHYHHHYHHYHYYCPTNLHHHQSPYHHPPHPAFLAPPPPPPPPPPPPPTASATVPPSHHPLHHHIQAATATAIATPQSIMTTSAAAVNSPATATSQHPLSHQFYPALPSAGSNSYSTNNLGTGPLYGYDEDLSMTSCSSTNLSLPDSPSKFTSLCAKTNLTATNNKRKSLINDQTTANIKHYTDLSASIPRPPPPPLLNGSTSNHHHHHLNGVTPPHYEHSITKGKIIFEIFILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA21</accession>
    <name>A0A922IA21_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL33</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L35a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPL35A</name>
        <name evidence="7" type="ORF">DERF_001205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA21"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9527165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="142" mass="16258" checksum="59587E0AE0076FE5" modified="2023-02-22" version="1">MSDIKKSSSKQPVTSDGKKRVKRKRVSNPATPGRLYVKAIFTGYKRSHRNQYENTALLKLEGVDKRNETDFYLGKRCAFVYKAKNNKPVPKRPGKLSKFRVIWGKVTRAHGNSGAVRAKFHKNLPPKAMGRRVRVMLYPSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAF2</accession>
    <name>A0A922IAF2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_002335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAF2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037364599" description="Nose resistant-to-fluoxetine protein N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="771"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="804"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="848"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="892"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="922"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="4">
        <location>
            <begin position="292"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="545"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9528382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1024" mass="119261" checksum="6EA059FD93F02227" modified="2023-02-22" version="1">MIALKTFHFIFIIATTTIHLNNGLMNNLNDPNHVNVPDFQPRFRPIDTMIMMMMIRAKRQSNLTLSELDDNNKENIFSTTMLPLTPVTMTGFKNSTIITTTTSSTGSTDSNHHSSSIDNRKVQSFISLIKIEDDFKPLFKGRIIPKNELNLTDKARKVMSELDYYDDLDNDGDGEDYESDDYDENIENVITIVTSTTESSVKKTDGNINNNNEDSYSEEDDIDRAVGGISGILEKLIRGPNKEEINAKSKPEDVYIFLSRIIQNEYGKSIKATIPRIYDYQFPISERISQRCFNSFAQFADRLRKHYIWPHKMIEASASFSSFNKFALRSYGDFDSCLDIVADDGDRRTNEVFFTGQYCLLQVELPLPELKSSITYYDRILYFNQTELFGTFSEYFMMIAPFLYSNPLSFGLCLPSTCSASEIERVGNFFLHRLHINIRRSSDCYSRLNMTVEALPEDFYELDLESIKQMQSFHIGQFIVYHRYSNETLWKSHQRDRPKSFIVCFSFRYSLEQIFIIRDRYVCQQMLGQPIDFLKNQSQMVNTVCLDALKSIALAWICLSNFYLLGYQPQMISSLPHLRDLVFNMRTNVFYQIVIQSWLSFEIFFAISGFLLAYTFLPYIAKHEGRPSLSFFFAKRFVRLLPSMFFLCMAIKLLPLWKNAGPLYNSSVEKILQPCQNHILRSLLFFADFYDYNITCLPHLWYISNEFQLSMLGVFVLIFVYNRRKHAMKTFFTLIMIGILFSGLIAYRLQLKSLIIVNAIMDEIPNIFKSIHFNGFAHFQSYFAGMALGYYFRMNYSQAAKPFNFVLPLRILIALILLTLSSSYAIYIPLIFSHYTSPTSDDVNNWLIILYYATARILFIGPTLWIIIQCLPRNNIFTKVLSWSIFRICSHLSFQIYLWNLIIIWIYLFTKRTLLEINLMESFPVAMSLFILTVVISMFTFLLFEAPYRNLFRYYFESPRTHSNCSTISMNDRNQNNVNTTTTTTATTMDNGQMKTTVLIAKQNDSIRMNEYRVYDNPNIVIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAQ9</accession>
    <name>A0A922IAQ9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAQ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9643" checksum="99AD309C226233A4" modified="2023-02-22" version="1">MKRSFVYPIKNHRHCNQMVKSFIIISIITEYGSIIIVLLTITKIIKKIVVHKCNFKKQMKVKFAEKSQDNCCESGQMLTNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB17</accession>
    <name>A0A922IB17_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Brefeldin A-inhibited guanine nucleotide-exchange protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ARFGEF1_1</name>
        <name evidence="2" type="ORF">DERF_002201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB17"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000044">
        <property type="entry name" value="TBC Kinase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="839" mass="97244" checksum="B18C76D97E81FCF7" modified="2023-02-22" version="1">MVMKLSDNYKLATVAFESTVNQNDMFGTNGLPLTPPSITMIGNFHSFVHSFNAANTLTPYLTHYLDCIRSKNERITLVFEHYASCVAEDNSPISNENLQSILQCGLYGLYHLHYVIGAVHGLISPSAFLTTNDQKIPYKLTHWAINIITDMGRLCQTRIYPNDIRFISPEQCLLLKPTKKSDIWSFGLSILYLMFPNQRQNFPYNPLELIDDSNGFNSIMVKLGIEIKDLSEKWMNFFQSTLNPNPNERLSIKELIAIMAIPEPQYYTTYEKFIKTKSYQNVNEVNDEEFFKISNFINLHEFYYLWSIAYPSKETNKEEQKIPTILSIPKLVILENECSNQDNCDSNHNRTVPDDENNLIEKIMSIDLETNWKMVRLPSNCDFKLLPVDTINQRLLKLSSEIFSPLLISDANLFNNRPESKQSCESLPLPIREMDFDYQCERLFLFKALLNGYPFLRNQLITESKTDICPHYRAQIWCSLLNVRWKDKLLFEQIDKISKTTTDRQIAVDIPRCHQYNDLLASAEGHRKLTRILKAWLAYNESNGEVYWQGLDSLAAPFVILNFNNESQAFACFDHFVLLSNHLASLKFVPDLYAISWFLTMFTHILPLYQIFQLWDTLILGNESFPLFIGLAILHQLRDRILDFTFNDCILIFSDLPQIDIDRCVRNSIKFFCSTPKSISRRNLWEIHALKKYPRLPRINIEDLTILVDRLNLSNCTATAVAFDQQQSLCSDCGRNTQLVLIDCRSKDDITKYGGTLINSVRYEDFYQELQKEITNGNKTNRSTKCHYQQPHGKHDLIIVIDSIEKTLELIENFSIPRVCYLDLSSSDPGYIPKCLLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBC4</accession>
    <name>A0A922IBC4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTF/NF-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_000345</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000647">
        <property type="entry name" value="CTF/NFI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020604">
        <property type="entry name" value="CTF/NFI_DNA-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019548">
        <property type="entry name" value="CTF/NFI_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492">
        <property type="entry name" value="NUCLEAR FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492:SF8">
        <property type="entry name" value="NUCLEAR FACTOR I, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10524">
        <property type="entry name" value="NfI_DNAbd_pre-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51080">
        <property type="entry name" value="CTF_NFI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CTF/NF-I" evidence="9">
        <location>
            <begin position="598"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="792"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="981"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1074"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1243"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1299"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="797"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="981"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1074"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1249"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1299"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1344"/>
            <end position="1357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9526244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1357" mass="149227" checksum="B684332C47A8F993" modified="2023-02-22" version="1">MSAIILMNESQSTIACMTAKFRSPHHQMASSSSFHVNYCAYDIDTNNTGQSININEFEHQTQQQQQTTINATYGSLITVHPLSSSVHCDQQRSTAMMDMMMAYGKEGSTTSNPSFGENVNVQMLQHEWDRRYNGSDVRQSVMHKSSSKKTTNENSVISSSHEYCTTAFMNDSYRHKNRLVASSPQSSTTEARKEECLSLLALTSSCTAMVRKENGASETSNSYVSKMNTNITSIKERSIRLTPNGDSQISSYGHDANVDDEDEQHTDSSTTAFSSPSCWSPASSSTSPGSIATAVVNGGSSHQNLHHNQQHQQQPQNSGHSEQPEVVNNHNNHVYDDHSFSRRRRCYSAIASSSTSLSSPPPPPPPRPSLSSSSSTCHRLISVSASSQQYYPSSTIAAAAARQQQQRQPYQQQSQSMASPVILDCTSQTSTTGETENSIGNRSESIRTVAKSVTGNKQTTDSPKDRSREVRDVSSASSSSTSPTNGRLHRNSSLNTPVTSSHSATVVHTMTIGQSQRQPNHHQQQQQQQSCATPPTFIVRSNHTQHQSSSSSSSSSLSTAVSTNIGSSGSVANADPMNCIPLKGATSVAAVDQQSNVDGSVTSFIKLMYDDIIDPLLPFVKCFSYTWFNLQAAKRKHYKKHEKRMSLTEERHCKEQLQNERLEVKQKWASRLLGKLRKDITQESREDFVLGITGRKRISCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKAIPLESTDGERLEKSADCHYPNLCVNPYHINVSVRELDLYLANLIFSHEHLRGIPPPANIEIQGSSSDTNASANVTGNDDPTHHHHDSQTQTTTTSLAMNSCTVVFTSEELFRLSRASIMQTGQLVTYPQHQEEEQQQQSQLGPLVHDVNMEEAMAYLSTQQQQLNSSTSSPSPHPLNYTLSHTPTGTVDNATGLGGNGSDCQSPNTQMGVVAASIGQPFHGQQAPSPINAHHHHHHHFNNLIYGNQYSAGGQHQPETTTNNSNQQQQSQTVVIKLEEYPDEYYQHHHEQQQPESLMGDESSNATVIGTTASDQESFYTLLAAAAATTSTVATTTAVTNSNVSSQQQSNSLRRSTSAISPQVNKRQRLLNNDQCNLAFMQHSQPANATAQLLQRHSLMIDANVSLLSHSHHQSAMRTSEAETESGWMSATNESGWHCSGDNDTNSEAMVKKESSMCPMLVNVHDRSHPPIDEQLLTATTTTFGGGEQYEYQHHYSQYHHGQSGYVEMVGQTNHGTSGDGTTSTASDVGSPVTNSVVGPETTSILEQSSHIHSYGHHVQMAINTNMDSTNDSHNESAIQGHSSQSECSMDNIHHPHQQQQQQQQHANQIKVKEEIHDDTTGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC39</accession>
    <name>A0A922IC39_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PTPRZ1_2</name>
        <name evidence="12" type="ORF">DERF_001580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd14549">
        <property type="entry name" value="R5-PTPc-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001386">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000068">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000013">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase zeta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF540">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 99A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="319"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="11">
        <location>
            <begin position="417"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="620"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="816"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="948"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1236"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1318"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1344"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1236"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1283"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1344"/>
            <end position="1362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9527571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1415" mass="161152" checksum="A1D45FA4912877D7" modified="2023-02-22" version="1">MSFTSRSVNLSWAPSFNSHNSPVLNYIIHTRIGENGDWDSMNGISTLDNRTEYYIDKLQPFTVYSFRVIAVNAIGASQPSKESYYTVTLREIPDGIPIGFRCVNKSSSSLSLEWHPPPRNTIHGEFIGYRLRYHKNGNSASLLVLHEREITIGDPEARTSSSSFSHLLSNCYKSLSLRWKHHFRRQHKQIERQPYVLCRKSSPSSSSRSIWHNTRIIICLLSNILISLFFFHLVVANDELQIPTPSSSMSTNVSTTTTTTTKLAPIIITTTGLPPTQNYTIRNLEPYTEYFVTLRVFNPKGDGPVATLAATTDEGVPSPPRNVTVQRVNNLMARVQWSEPLQPNGRIIGYHIYVHNMAANLTEVKRFQTSDLSQHLMEYTIHNLKPFTQYKVWTKAYTERSEGEASRTIEFRTDVSGPSAPYISNLTCEGDDALIVQWTRPERFYHKIDYYFVYYRSEHDSDDNFDEIPINIPGFDTSFEHYTKITNLTKGTLYEVKVQGATRSLKESSKLYRGDFSESRKVILQSYASGSDLISASLMAGLTCALLAFLLAVASFFLWRKYFQAAYYYLDDPAIGGGSNPRSSPNLSEVYIDEAEYPPILTGQWSRHVQDLHCDGDIGFTREYEQLQRSTEVHADRLSSEHSHMAENKTKNRYVNIVAYDHTRVLLKPLPGQKKTGHDYINANYIDGYRKSQAYIGTQGPLPATFDDYWRMIWEQRVCIVVMITNLMERGRSYLQRHAELMDDGRKCDMYWPKEGTETYGIVQVRLLQEVVMATYTLRTFHVKNLKIKKKHGNERTVYQYHYTNWPDHGVPEHPLPVLAFIRKSAAANPPTGGPIIVHCSAGVGRTGTYIVLDAMMQQIKHRNCINVFGFLKHIRQQRNFLVQTEEQYIFIHDALLEFLDAGDTEVPSTHLLRYLQTLQTGGEPKLNGTDNGLIPSTMDKHSHWPLLERQFRMVTQFKAKDFNVVSALKPCNKPKNRSLNLIPLEAHRVHILPRTPGAEGSDYINATFLTGFSRLREFIITQHPIWDTVPDFWQMIWDHNVQTIVMLSSVIDEKEFPQFWPDKEDEADYGSFKVKLIEESRLMLNCENGGVGGGCPSGAGFITKRDLMLQSTQDDYELCCRLVHCSDWPERQPLAQVFDLIKIVQDWCTSDTVTSSGVLGPVVVVDKFGGTEAATFAILTTLYKQLNFEDCVDVYMYAKLYHLRRPGIWRSQDDYLFLYRALEALVSSSSTVQYTNAQTPQSGSGTNVNTLTSTSSATHLMGSNTPPPLTTSSTPNEALAQSYATLPRVSSRNSQQQTQHNQFGTRGPINLDQQQQTHYVNQHQHHHHHNHQQHDISPINHHQAVSQPQQQHYHQHPTVHQNRNRTPSPFMCDSPQQLLSVQATTGTAGYNSYHISMMSTANANVEQANQIVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ID30</accession>
    <name>A0A922ID30_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ID30"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="8073" checksum="963D23BADB6CE944" modified="2023-02-22" version="1">MEKYIEHEREFQIIRFYYYQTTRMIACNIEFRQGLRRQFDHLFSGCENLKKNRAKYRFRREDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDM1</accession>
    <name>A0A922IDM1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDM1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037173050" evidence="1">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="111" mass="12327" checksum="27E1AB391D696FDA" modified="2023-02-22" version="1">MSIAVLLCHKLLLNELFTPPNGNVDDTVVGTPDYDEDCVCTYDRFAENVNLFGCDDVDVFETLKLKPLLLLGLMLVDVKSNPVLFPLDGVGFNIDDDPIANMFDELLANEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDU4</accession>
    <name>A0A922IDU4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDU4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036789513" evidence="2">
        <location>
            <begin position="28"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="126" mass="14079" checksum="87D7BDBB0A188128" modified="2023-02-22" version="1">MRLLTIILFVITLIVIDNNNFVKQVDAKKQNSIQSINDDDGGGGGEKTFDPPIDSSDTCNISNDEKLATKTIAKKSKKAKEVIVEDIIVETKEQQDELIAQQKQIDENDTPPPPPPPPIIMKRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE00</accession>
    <name>A0A922IE00_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TPT1</name>
        <name evidence="5" type="ORF">DERF_000951</name>
        <name evidence="4" type="ORF">HUG17_4215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE00"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7641171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9526893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="173" mass="19672" checksum="DAC04F4AD5F0C1D0" modified="2023-02-22" version="1">MIIYKDLITGDEMFTDSSKVKLVDDCIWEVECQFVMRKQGDIAIEGFNPSAEEADEGTDEITESGYDLVLNQRLVEASFSKADFKNYLKTYTKTLQEKWKNLEWSDEQIAEAKTKFTEAVKKILPKVNDAQFYLGNSSNPDGIVGVLEFREGDDGNEKAVMNFFKHGLDAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2023-06-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEX8</accession>
    <name>A0A922IEX8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9530281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="10" mass="1310" checksum="739430CB172B172B" modified="2023-02-22" version="1">MSELELEFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFG1</accession>
    <name>A0A922IFG1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding protein NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NOB1</name>
        <name evidence="13" type="ORF">DERF_002297</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in mRNA degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFG1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="12">
        <location>
            <begin position="10"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="11">
        <location>
            <begin position="220"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9528344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="379" mass="43512" checksum="DEFB8FEFB4E27C2E" modified="2023-02-22" version="1">MMTQKKVQHLVTDSGAFILNCPLQDYGETIYTIGDVINEIKDEKTRQSLQILPYELKYREPTDEDVKFVAYFAKKTGDFNQLSTTDIRLIALTVRLEKEINQGVNLKENPDIKILPTKSSNSNSLTVKDLEMFGYDIKNAAIDSIQNFGDNEMQEIDKDGWITEENFEEIRDKLMGIKFDEDEDDDDELNIACITGDFAMQNVLMQMGLNVVSPKDGLHIRQTRQYILRCHACGRINPSTATKFCKYCGNCRTLKRVAITINNDGTVKMHINFKRPIRIRGTKYSLPMPRGGKHANNPILCEDQRIPQQRKSKAAVEEKKLLNMETILTDPDYLVRSNPFAINDVYSRASRMTPRQRKQINPNETRKPTGNKKKSNKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFR9</accession>
    <name>A0A922IFR9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">EPHA5</name>
        <name evidence="26" type="ORF">DERF_003296</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">Derf</strain>
            <tissue evidence="26">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="26" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">Derf</strain>
            <tissue evidence="26">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFR9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10319">
        <property type="entry name" value="EphR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05033">
        <property type="entry name" value="PTKc_EphR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000089">
        <property type="entry name" value="Eph receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000019">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000143">
        <property type="entry name" value="Ephrin type-B receptor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1770">
        <property type="entry name" value="ephrin a2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027936">
        <property type="entry name" value="Eph_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016257">
        <property type="entry name" value="Tyr_kinase_ephrin_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF14">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14575">
        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25599">
        <property type="entry name" value="Ephrin_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000666">
        <property type="entry name" value="TyrPK_ephrin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15 26" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Eph LBD" evidence="25">
        <location>
            <begin position="9"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="314"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="418"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="648"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="23">
        <location>
            <begin position="938"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="773"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="654"/>
            <end position="662"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="680"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="58"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAH9529410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1013" mass="113923" checksum="581F53568DE843FA" modified="2023-02-22" version="1">MIKESGDAFKMILLDTTQESSLDWTRLPYGPQARTPGWVEESFTNFEQGINWRSYVVCDVAYNNVNNWLWTPFIERHNANRIYIEIKFSMRDCNLFPGMALSCKETFSLLYYEHDGLNKEPPPWEPESYKLIDRIAADEGRFTSNSEVIINTEIRSVPVTKKGVYFAFRDQGACLSIIAIKIFYITCPNITTNFAFYPETPTGRELTTIVETDGVCVANSQQVEIPRLLCKGDGNWTLPSGGCKCMPGYEPMGQSCQVCSPGKFKPIVGDELCQPCPAHSKSSYHGSTECRCDAGYYRAPKDPKWIPCTQPPSSPQNLTINFLDQSTVILTWNKPKFLGGRNDTVYRISCDYCPSSTNYVPSQETINDTRVVISGLNPMTSYRFQVYAENGVSGYDSSQFVEITATTEASALPATTIYPPILRITSADGTQISLAWKRNPNDNSNNDPANEITAYELRYHSNDIERNSSSILISKDQFETTITGLKPQTEYTFQIRSRTKTGWSEFSKPMMKMTGQRLANPAYISGDNESVQTRIIIVGVILLIVIVTFIISLVLFYLKKNNEDCNKKQPSDCDTLEYRSCGMEGKKLVSTFDHAPIVPTPRFNSTFSVATPLFTNCATSRSYVDPHTYEDPNQAVKEFTKEIDASHITIEAIIGGGEFGDVCRGKLKIPGKSEVTVAIKTLKPTTAEKPRLDFLTEASIMGQFDHSNVIYLQGVVTKTNPIMIITEYMEHGSLDAFLRANEGKFTILQLIGMLRGIASGMEYLSTMNYVHRDLAARNVLVNSSLVCKIADFGLSREIESATEGAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSFGIVCWEVMSYGERPYWNWSNQDVIKSIEKGYRLPPPIDCPDAVYQLMLESWQKDRSNRPTFTQIVKTLDKLAKCPENLMKLAQQMTRVDPFIEQTSIPDVIQFKSFYEWLASIKMSRYQINFEHAGINNLPAVARLSPQDLLTIGIDIPSHQKKIMNSIFSLRAQNSIGSPEGFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG13</accession>
    <name>A0A922IG13_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Metal ion binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SCRT2</name>
        <name evidence="12" type="ORF">DERF_003496</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG13"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000043">
        <property type="entry name" value="Scratch family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000169">
        <property type="entry name" value="transcriptional repressor scratch 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF60">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR SCRATCH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="100"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="259"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="443"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9529620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="586" mass="64010" checksum="2B998B77B86F8BE8" modified="2023-02-22" version="1">MPRSFLVKKATTNYGQQFVKLHHHHHIGGRSISNTGSSGGGGDGQQQPPSSPTEGDCAPATVSVIGFNNANTYHKSVHRYSLNYGTNVDHSANTTTKIVETSNKLKDSSSSSSTTTSTTNGVIVHGKQSQNNHKQLLDLSNKRTRSSNNSISHNSNGYSSSSLYKSSNDYNNSGYHTASEDNTTITSLTENTESTGYNSSSDDHDDGTDHHATNSESNNSNDVTLIKTHKKHGKKNITISYTYDAFFISDGRSRKRNINGINNGSNGNSAGNSVGGGNAGHGNGIISDSSAGSIDPKERQRYSCTECGKHYATSSNLSRHKQTHRSPDSQLAKKCPTCHKVYVSMPALAMHVLTHNLNHKCEECGKAFSRPWLLQGHMRSHTGEKPFGCAHCGKAFADRSNLRAHMQTHSAFKHFRCERCNKSFALKSYLNKHYESSCFKDANNNNNNNNSNNNSKQQTTEQSMETNGNNCETLENHCSPTSSSSSSSSPSSFSTSTSFSKLNNNNKQSTTTTTASHQMNNSNSEKQQQKQKQEPEKHQQPQQRPSYTTTTNPYTNSITITRSKVLQQNGGGGSNIIISNKRKSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGC3</accession>
    <name>A0A922IGC3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGC3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018881">
        <property type="entry name" value="C2orf69_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31296:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTEIN C2ORF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31296">
        <property type="entry name" value="UPF0565 PROTEIN C2ORF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10561">
        <property type="entry name" value="C2orf69"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="273" mass="31817" checksum="C3A80EF89921FD4F" modified="2023-02-22" version="1">MSSLRYLMNVEGISGRFNNLIYVPCCMKRTDRFVWPIVCYFGGDIQNFHDEMIKQNNHEFLSYSLENVAKKLSNRFNEHDIFIVQPSKMINSFSLYDNFLQTTKPYGSPLYDDNDQSCFDHFYRLLTNASKQINITIDSSIEACLIAFSKGQIVINQLARSLHQVSPQSKFKLTDLYLLDGGHNGSKDFWIIQSKFIDSLVKHGCQKFHIGVTDFQLNKPQNIRQEFEKFHKILLTMANVNVEKTYLAQNDFAHLSPINLHFKLLDYLFENLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGP5</accession>
    <name>A0A922IGP5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc carboxypeptidase A 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SLC6A2_2</name>
        <name evidence="15" type="ORF">DERF_003437</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGP5"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000002">
        <property type="entry name" value="Carboxypeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000001">
        <property type="entry name" value="Carboxypeptidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037530029" description="Zinc carboxypeptidase A 1" evidence="13">
        <location>
            <begin position="26"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="14">
        <location>
            <begin position="143"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9529559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="448" mass="51192" checksum="C03A83092C6F502C" modified="2023-02-22" version="1">MVWIESIVFGLIFTIFFHNNNHVHCNNLTSVVKKEIAYDGYKVFRVRAENIDQLLYLRQLSDDVEKVDLKIDFWSMPNSLNSSIDLMVSPELGNDLQTILAKQNIKAETLINDVGRMVEMQRDNVEDSLFYSGFPNDTVFFQRYQPLSNIISFLDDLIRSNQDVSSMETIGKSGEGRAIKIIKIGYPPATGQNKSIIWIDAGIHAREWIAPATATYIISRLIREKDEEEISKMLKTFDFHILPSANPDGYEYSRLFDRFWRKTRSRNAGTFLGFFCVGVDPNRNYGYQWSRTGSSGNPCSNTYHGPRPFSEPETAAIASYVMQNKDKIKLFLSLHSYSQLILTPWGWTKDLPKDHADMMRMAEIASRAFKMRYGTEYRYGSSTSLLYSAAGGSDDWAYGAAGIKYSFTVELRDRGTYGFLLPARYIQPTGEETFDAIVAMLNEIKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYB8</accession>
    <name>A0A922KYB8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_015948</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYB8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="680"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="757"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="871"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="921"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="946"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="12">
        <location>
            <begin position="469"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9491217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="982" mass="110165" checksum="6E3BBD1D067CC495" modified="2023-02-22" version="1">MDNRLSSSTPGIIQIEMDTSYTMSNYSSNSSIINRSSPSQRSSSSSSSSTSTSESLAMNNGDTNNNDGRITETSLLYSSATNTTIENNGSTNNHNDLDNNNKMKNKLEEQQEKEEMLAEQQQEINGNPIDPYRTIFKQSKQHHTRQKSDSSSNKIGRFTVRTFDQLNPSQNFDDQSPYSTTTNCFDTITSLIPTSNFEETEYESDSQDVGLIMDHGHDPDDEEMAIGNDHNANRQLIIPHTEVLISRLRNEVVKPKNFNNEVRAGRDVKSFLANPCVLLDLEGDSVEEIIDQMLTAINNDLDGTLLSEARSSLYDAKNAFQLSDFLQGIYHTETGEYLHDPTWLCTFATVNNLSARRIVIARLDRPSNFGPTLRHVQFIVLVLVPSKEKTSKSAFEIARTFASLFADSTLRMSLLQCESQVEFCQQISDRVAFLKRRQSSKKFKSFSLDKLENHPDHLAKQKQSFGFGKGLVNDFRRRIKYYPSDFIDGIVGKNTISKVSAAVLSIFFACILPPIAFGVVNEHNTHGLIGPKQGLIGQAIGGLIFALTSGQPLVIIATTAPLTLYVKIVYQASQDWHVDFLDLFAAVGCFCAFYLILYALLNVSNLMRYVTRSTEETFATFVFVAFTAAAFTECHESFRKHYCFDNLTGYSNLTTTIIDLNDKIDMDDLPIRDCLPAKSILFLFLMLGTVAMAVLLYNFSSTPYLNSILRNTLADYALPLSVISFSLIGSVLFRDVHTDSFIINADFQWRLATFRTLTPTTIGLAAFLGFFLSMLFFIAQSGSAFHWDLFVLGSLNAVLSMIGLPWIYGILPHSPLHARLLADVVPATDSQHNSTKSYVVVRVRETRVTGVLVHLMIGSIVLVIPNSLSNIPVAVLCGLFLYCAISTLRNNSIHDRVVLVLTEQHSYPPTSYLRHVPQRTVHCFTATQLALLALITFVGFCPWKSFRLFFPFMIALMIPIRRYILPLVFEEKHLKIIDSKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZK7</accession>
    <name>A0A922KZK7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_010840</name>
        <name evidence="3" type="ORF">HUG17_9561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7642870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZK7"/>
    <dbReference type="OrthoDB" id="10642844at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7642870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9506093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="184" mass="20356" checksum="16E18830D51B2307" modified="2023-02-22" version="1">MNVHNFIFVIFVLTTMMVATIVHCQGRIGAIKQLSEISKKQKDPINKYGPYVKPLKQLLGISKGSGGIFSGGSSSHSSSNDYNRGTSIDRSRDYNSDSSSSYNSGYSSGNRNSYDRDRDYNSGSSSSYNSGYSSGNRNSYDRDRNYNSGSSSSRDRNSYSGSYDNDRYSPSSSSYNRGNSYNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1K0</accession>
    <name>A0A922L1K0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Translation initiation factor if-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MTIF2</name>
        <name evidence="8" type="ORF">DERF_012288</name>
        <name evidence="7" type="ORF">HUG17_9046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1K0"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="68"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7637942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9501440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="644" mass="72713" checksum="0BB23A63E8AF5191" modified="2023-02-22" version="1">MQIRPLSLSMRIYFRLSSSMRAALTKSYSTKFKNDIENHHQQDQITAESIVERIKNYSQLKQGKEFRIRPPIVTIMGHVDHGKTTLLDSIRKSELVKQEHGGITQHIGAFVVSLQDDKNIRQSRIEDLVVFLDTPGHKAFSSMRERGALVTDIIVLVVAADDGVMEQTIESISFAQKSQVPIIVAINKIDKIQNNPDLIENVKFGLKSQGIVLEEDGGDIQSIKISALKGEGIYELKEAIIALAETLELRAPIDGNVEGSIIESSIHPHRGRLTTILVQQGTLKRSDILISTNSRNGNVSWAKVRAMFDEYGQVINEVQPGFSAQVIGWRDDTLPDAGDQVWQFNSEKQVRDILGMSKELERQIRLSIDAKAIEQKREEHDTVYKTELAARREAGIRYKRKRSSIPRTKLIQTEGDEFKTSIVLKADVNGSLEVLLDLFDSYPNETSPAKLNLIHYGLGNVTENDIELASCFPNGMIYTFNVGVFTPALLKHAKELNIPIKRFNVIYHLVDHLKETLQERMPFVDKEEILGEAIVIQEFVVNDKKKKVPVAGSRCSKGILKKNALYKLIRNGHIIAKDLKLSSMRHHKDEVDTIKKDFDCGLMIADNIISNKSGQVIRFQSQDLLICYQLVNVHLPLQWKPKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L222</accession>
    <name>A0A922L222_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_009961</name>
        <name evidence="9" type="ORF">HUG17_0037</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L222"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 7" id="KW-0186">Copper</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="8">
        <location>
            <begin position="119"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7644499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9511507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="259" mass="27969" checksum="AC7EC7E1AC743EEA" modified="2023-02-22" version="1">MAIGTIAKIILFTFGCYQLFMIGICQSYFGGGVGAGGSNGYQNNRGNAWQGYRSYFEQPQQQQQPFQQFYSFVPQQQQQQNYFQTRQTPSSSTTSQVAASTTSASESLIAVAKLEGQNVQGIVQFRQMPNSMNLQVSGRITGLTPGLHGFHVHQFGDTRNGCTSMAGHYNPDNNNHGAPSDQKRHAGDLGNIEANQDGVAEFNMFDQRISLTGQYSILGRGLVVHANQDDLGRGGQQDSRTTGNAGGRVACGVIALAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L355</accession>
    <name>A0A922L355_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_010059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L355"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9511611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="341" mass="38820" checksum="F57278EA4D0673E0" modified="2023-02-22" version="1">MKAPCEIKISSLINMEQSQSQQQPQQQSSSDISDLNSGDDSTLTTTMDNNNRCYGDINIHHNDNNGDVVDDDDDDDDDDDNLDDAETTTTTSTTDQDEQLMQIMIQQPNQQSLINDSPTNTTTTATTMAAIFSTSSTMITTNSTATTTTTTTANDSINLQQQQQQFMMNNKTSQQMKHPQQLNNSRWPLQKQRSYTITSTQSDQSSSTTTIIQRLLDKIENLESDLNHIKQERDILYSENERLCFQLQMINEADKHQQRSSARKQQQQQQQQLQRQQSISGYDNNNLINQSISINGYSGGDVFHQKPHPITTQQQQQQRRLILILIPVIIIKILMMLFNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3P7</accession>
    <name>A0A922L3P7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_012697</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3P7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9501888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="327" mass="38634" checksum="999166765F077456" modified="2023-02-22" version="1">MNFSITINDNLSTLLDLKDFQFLINEPNICRSSFDHSEQQYSNIFLAIFIHSATKNFDKRDIIRKTWGNHSIGFGIDNHYNVRLVFMLGTTKNQTIQNQIQQESQHYGDIIQGSFLDTYRNITYKHVMGLKWINHFCPHASYILKADDDIFIDLHQLIYYLHGKFGDHPQRLMACYVNKNSRVSRSYRNKWRVSYKEYSEQYYPAYCDGWTIIMSNDITLDLYRIAGNRPLLWIDDVFISGILANDLHIDHFDFRKSIHCYKNENVKNWLIKSTKSSAISIPPMLSLIDANHYNDPNEISHTIISLWNKTVEYYRYNLNISIDQIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3Y6</accession>
    <name>A0A922L3Y6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">QTRT1</name>
        <name evidence="8" type="ORF">DERF_009366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3Y6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="16"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="263"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="6">
        <location>
            <begin position="287"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9510865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="409" mass="46535" checksum="FCDBC7E83FCAB902" modified="2023-02-22" version="1">MDRPLYFETITKCKKTRARVGRLLLKSTSEFGKDVEIETPIFMPVGTSGAMKSVMPEELEQTGCRLMLCNAYHLASQPGADVVNRIGRGGCHGFIRWPHAILTDSGGFQMVSLSKLMSINEEGVRFESPYNEGEIFLSPEGCMEIQHKLGSNIMMQLDDVVSATAQDDRRFEEALYRSIRWYDRARKYHHETGRDQLQNLYPIIQGGLDESFRRISVRELVARDPPGIAIGGLSGGEAKEDFIKMVAISTENLPDSKPRYLMGVGYAVDMLLCVALGCDQFDCVYPTRTARFGTALVGLGKQLNLSNQRYLTDKLPVCPDCDCSTCLTVNRSYLCQLFRSKNSIACQLLTIHNLRFQMRFMEMIRSAIKEQRFEQFIIDTLRYNIGTNYNDYPEWIRIALDILQIDFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L423</accession>
    <name>A0A922L423_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">10 kDa heat shock protein, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Chaperonin 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HSPE1</name>
        <name evidence="8" type="ORF">DERF_007845</name>
        <name evidence="7" type="ORF">HUG17_2150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L423"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7646612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9517151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="102" mass="11196" checksum="046221E22978A9A8" modified="2023-02-22" version="1">MAGNIGRRLIPLLDRVLVERFIPQTTTKGGIVLPEKAQNKIPTGTVVAAGPGRTTEKGDVIPMGVKTGDKVLLPEYGGTKVEIEDKEYYIFRDSEILGKWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L652</accession>
    <name>A0A922L652_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L652"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="597" mass="68167" checksum="4412019E0BBBFE3E" modified="2023-02-22" version="1">MKNKILNDFKQGDKSNLEQMTFNLWNNTSIDTSSASNQFFQVSSTDSVDSAVGVERLESWHESTQSPLSQMTISNRLSMNNLDPNQSLGPINHPPSSNLVMDDLFMNQMCTLNIDMSFDDRVFFGVHNFSQLKCSLSESQCNVDFSATNNKVAIIGKSENVTKMCKSFFLHSTFVLQFEFYFFDEISYAEYMKERFPTLQTEYEKLDMQLGFYQLGRVLPNFMSTLQMPIVSRDARVINASYLESIENETGTKIKSSRYHCQYYPYENIIITGADILSVFVSDLTMLVKCISSLNYDRSSIEVTISPCVSNPSLDSKILSIKTNEKHIDKIYSIHKELIDSMIINGVISEHRIDTFISIHDSSNFRFTTRNRNFSLFVTFPFYSRISTSYNKTTVSFRTEIRFELNPPYATSFNNNLQSGLGCMIMLPIFFDVTVSSLANSNSTCLSSGSISKFSSTVVCEVLPESKIQTFDDFSTDFKIKFDRSMHITITHRCLSVYLHHSDSIDSNFAMIVSSHILLLLLSFIMADFVLVQFLSGHGNFRHYLYKIGYSSESLCWCEMDTQNSVRLICSCPRFLIFRTNIENLCGLSLCKETLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L700</accession>
    <name>A0A922L700_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ectopic P granules protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EPG5</name>
        <name evidence="4" type="ORF">DERF_005811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059030">
        <property type="entry name" value="TPR_Epg5_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF4">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26103">
        <property type="entry name" value="TPR_Epg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epg5-like central TPR repeats" evidence="3">
        <location>
            <begin position="1905"/>
            <end position="2319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2768"/>
            <end position="2787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2768"/>
            <end position="2784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9522219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="3085" mass="361974" checksum="41046360B25EB9A1" modified="2023-02-22" version="1">MSENLHSTTSTNDEMDTIHNMSNDDSDGQTKSLYPNIHSPPQSLSQPSSSTLTLSSAQIPSQSMIMTSSMLSSMSLSGTNRTQQITTTTSSSCQKLEKLRIIKPFDERQLLEFYRNPLLDSNEKFIQHFQERYFSRSTSATNDYYDLIIRLDKSVERFQDIRKNIDEYIEQINQAEQEKCWNRSEHHLHQSDRCGDGQLVEAQHDYQRYHFDQDYVNNTLDRYHYLLRERLVNEHVVHSYFHKYFQLRFELVIYEADDIIQRLERKITNYNYSNQQPINQNFDSHLSIGTVIDDQTSTNCSSSIFDQTEIDVVTQIYQLEPSTRLLHEQLLDLFAALFAYYRRTMADNNNSNEKLKLHCYQAIMHLCRKFLNKLAKYSDRLFLLNQILRCPAGSSSEFSNLLEPLDPLPLKSNGQQFELAKQYVDYGVVTIATILSPIKSCKSEHHSKMITSNNNAGEQDKSNKESLWLMVDNDLDDEEFCLDQSPSPIAELTENDIICYLSRVPFREMLHFMSLITDDNDGQNFENNEDNDTINSSTETSMIRLFAFSTRLIQIFRHGLQNFNCLRFKRLTLYLASMIKQIIKTISDNWRWCKEKFTTKDQALLIRLQVEFDHFMLRSITAILSTNRRGVWPLLAKIDFEGISEPMLWNILWVVYQNGRNEQNEIASGLCPYMSSNYWKDKFRSHVHWKFVFIEKLAILSLEEASGLLDFFYNMAISRSKFESLMELSSSSTTTMFNDLSFDNIQHVDDFLREIIERFAEICLLRKLYSYPLDFENQMSQINPNQYLILNNQEFYSTKGVACLIKLLTRYKSMLFLLLQFLQSINDESNLLIQPCLDLFTSIVINDWKPEIRLFSLLYKWLTERPYDHVHNRFARILLTKIGWNRILVQNDQCLMIPIQQQQQFALKLYQAMEQHFKSINRADAINSNNNDTKTKIMIEYPIIQNEHLSNEEHRLHIAQSHNPNDYGCWCWSMLLSLRLHPLDLIPDESCWDDIIYGSEHKNKYSSSRRKHWTMQYMMKFNYDSEMIQIARGIEMDNPYAIYIAAMMSDLLFNAGHSSIDLKRMTELNDQLIRGGHLIPMLHILYHFLPFCFENDGELRANSSFILSILTLLQNDMTAEQLSSIILLQRKHFSRTEYSQQTCQAWTECLFETMNRCLNMKTSSWLSSFMPQFLQSSSSTLNVIDMILGKITIIFDQLSMELLLENGDCLKLYQQYLCRKLYGRMMNWKLTQLDSVSGLSSAGNSGSGVLSSSSSPASWLSLYWYSNEINVPAYLPDKTLIRSPWMTPFHLLLRHCLNSKQSIRIRQPVYLIFLQTEIDIRRTFNIWNYLVFELRKTQWNSNETHIDYTMIETELTQACTIYEKAPLPCQLLPLNLLTVYLLKLIPTADSQSSSDRHPHPMIPLLWRQFFSNYFLYTDSLSTIGNRFIDTTRLKQLNDRLNSLFDYHNQRWIRLNNERPTNDSISIDSELVQNELQQQQQSDSISALLFEDRLVKLYRAYRIWLKDNRFLQYADLDDEQFAKPEIQIKLLNSVVSVSCGRQIIVGHNYHFIQENFWPEFDHLNTFFMLNYVHKIPLQSYILLHEQSWIRLVKPILESLKHFNDDFDDNDNGDDNDNNNIDRKLLKLPESSSNEIQFIDTAASRQSIRQSVEYNQSDRFGQIIEYFTKLTASLNCNILFLDSDIGYNLGYVLDDNNQFTVDFDGQKSEQDISIVFVIIHQIVDNIVEEARFVENQLEKFNTLNVEFCKDILPKLYHDVSRDLIQRISCDRSEFDPSGCTKPAAIKFEFIESLLNNYIKQKLDRNRAEMDTIITSLIEDVPGQKVVASIYFMQKIANYLLRFYIDGSYPQRSENNNQQQRIQRLFETMSGWINSINLIGIKYHLTGQLLDIFLDMLQKLSTNYVDEINHFYLNTALQRSVSMSLTQQLAPCLTPSKTSPKMFIQMYKLIGSRLNQQHQQQQQQQHLTSPPQSIFVLLSKFDVATWLQLSHLKDEQRLDLLECLFQCFTFFGPNPSDDYLVIYDLYRKHLQDMILYRFPIFMTNILAYMLQGMNEQQLAPTLWNSILHTFGFYTKSLSSFSSLTKYTRPKLNENSSYIDDCERELSIIDFDYQTFDDDLRMYVMRQKLFTSHELYNLLKLMLEFKHNLHNPQHQQQQQPEFLDHFKIYNVKFLQFLTFISYCWINSNATTLPDDISIIWLPFFENWRSWIFPRHNTKFIQWEHFCFAWQLFIISVQFMLDSFYDGQSQILSCIWQPFMTFILETRSVERTDVEMFESKLLQLKNWSQFYPSITDIKLMYESIVMERYSVERLNSFVISRIQWNQALLNSPQHISIDNAVEILENLTYTIISLVDQPYIGQVDFPTIPFWLLPSQKIKKIVITLLEVMKKRVSIDMVDKNLSTKQKSTDSDSDNQLLIIMRLLKALVQLHNVDTVTESETDPIRQQQNAAKVIYYAHSIGSFISYLANQNVDYIAKNPDSMRSFLKDSIESLRPTIDSFDMTDRVSIFCELLQSLNEIQDSFIRDRLATHFVTLFSYMTSSQLFAEIIFAIGKIIYSIKTAIFLLECLLENYFDLAGDLQYLIDNLEIVHLNKHLNTLNNSQTNLLQQSSTNCDGNNSDPITITTSGNHIEDFMLESIKTRSCLLLLIYIHRRLKHRTVPDICTRRYVYSIMMQCAQHFKFGTQPQHSQQLYGKFFDEPKQCFFWCRLFDLLTFDHSSISDGLNISIHHLSSLKTTNIMMTKSNSSILSTSRSLMDMPIVYTAKIAQNSSSSSLLSLPPQSSTSSPLSHTRKTGFMDPNQLSLDIHQEEVSQAIHTLLLLCQSLNSSISDSLNRGFFGLFRTQKPPSNQCLFLLQSLVLHGACTMMETFFPEFDYHQTSSSSTTTDHDEQSQAKIANVDTIRQRLQTDLNELIRTSHQRIRSWRKNKSFQDIWSLIDKLLDYTKPMVISVQCSNEYHHHQQEQHNIHQQSNNNNNRKNIIELNNEIDNHHHNPEIPIFLIGDDDDDYDGSSEPTSPIIDTAINNLINPNDNNNDDGNGGQMNNNQMELLTKQWLRYYIRLSQHQQQRFHLIQRWLLDLYNNHNYMKHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7X7</accession>
    <name>A0A922L7X7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="5">2.7.11.22</ecNumber>
            <ecNumber evidence="4">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cell division protein kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 19 20">Mediator complex subunit cdk8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 21 22">Mediator of RNA polymerase II transcription subunit cdk8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">CDK8</name>
        <name evidence="27" type="ORF">DERF_000091</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Derf</strain>
            <tissue evidence="27">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Derf</strain>
            <tissue evidence="27">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="5"/>
    <dbReference type="EC" id="2.7.11.23" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7X7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000088">
        <property type="entry name" value="cyclin-dependent kinase 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000122">
        <property type="entry name" value="cyclin-dependent kinase 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 23 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 27" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 23 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 24" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="21"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="400"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00075377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00077233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00079474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAH9525969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="470" mass="53783" checksum="D8AE86B1AEDE4075" modified="2023-02-22" version="1">MDYEFKEKLAQERAKVEDLFEYEGCKVGRGTYGHVYKARPKESNDDRVYALKQIEGSGISMSACREIALLRELKHVNVINLQRVFLSHADRRVWLLFDYAEHDLWHIIKFHRSAKANKKTVHVPKGMVKSLIYQILAGIHYLHSNWILHRDLKPANILVMGEGRERGRVKIADMGFARLFNNPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTNNPYHQDQLDRIFNVMGFPMDKDWEDIKKMPEYNQLQKDFKKQPYTNCSLVKYMDKHKIKSDTRAFVLLSRLLSMDPTKRITSEQAMQDPYFSEDPEPTQDVFNAMPIPYPKREFLTDEGNEDNHNNQANHGQANQQNPAAVAAAAAVVAAAANNNQQNQGVGQKQGPPGQSGHHGQSSSDMVSKSGQQSGQSQQQNQHGNHGGEDMAMDQWDIIIIHRIIQQIKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L889</accession>
    <name>A0A922L889_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="8">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SIRT2</name>
        <name evidence="15" type="ORF">DERF_007640</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="8"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L889"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 8 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="14">
        <location>
            <begin position="56"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 12">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="72"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="168"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="267"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9516927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="343" mass="39569" checksum="AAA631E7A6D3620C" modified="2023-02-22" version="1">MFKIIVEKSPKSQIIMPRFLANFIPSKFFNLFSGSSSDNDNVHENVDGISIENIVNGIKNRKYDHIIFMCGAGISTCMFKIVFYLIQLIITAGIPDFRSPKTGLFHQLEKYNLPYPEAVFDVQFFSSNPKPFYHLAKNLLPDKFKATPCHYFMRLIHDKNQMLRLYTQNIDSLERIAGIPADKLVEAHGSFHTGHCINKECRKEYSFESMKKIVLDNDREDNVVYCEDCGSYVKPDIIFYGEVLPERFYRLYQRDFINCDLLIIMGTSLTVQPFASLVELVGPHIPRLMINKTRPSSGHFSRNNRDVFIKSETDSACLELAEKLGWRDELEKLINSDDSDNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L898</accession>
    <name>A0A922L898_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L898"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="438" mass="49622" checksum="71F913959F49AC80" modified="2023-02-22" version="1">MSPSNRFSYSMPSSSSTSTTTTSKCQPLLLWPFMTQCHYDQQQQQQTIYHHHYYNQPNKRCLLMVGCLLFSILQALDQSPIFVTVAASSPIVDDDTASAVAAAETAFPSQKILDSTTKTTNDAVEKSLFAINNQPKQQQQQSILQRMDGQQFINVFDRLMDGELTRIIEQIKAKNNKFNSIIPNKLTAKQYISLLDNYSSGEVSRRIESIFSPTSLSPSLLNGGSNKRNRRSSFDSMTGLSIGYLKRRFDPMIGSAFGSPLKRGMNFDEMDHSGFAGFAKRSAVDFDEMDHTGFAGFAKRRSADFDEMDHSGFAGFAKRRNFDEIDRSGFTGFAKRSVDFDEIDHSGFAGFAKRNHRGIDFDEMDRSGFTNSFAKRLNFDELDRSGFNGFKRFYFDPITDHRFSLSELNKAIRQIRPLSMMKTQQQLSNVKQQQGSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8N8</accession>
    <name>A0A922L8N8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DERF_005429</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8N8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="515"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9521802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="781" mass="91178" checksum="435B899D66686628" modified="2023-02-22" version="1">MTDTNSSHNPQELTEQQIREIKDELNLVQRMLDHKIKGFPSQTTEDQLTTMKGEAKLFKEIIDRHMKHYPDGRPTNPNLPRIEILTEAIKTAFVTMHEHFEWNVMPFGLKNAPAIFQRIVYNILKRNGLTEFAHNYIDDIIIFSKSEEDHLVHVEKVLAAVQRENLKLKLSKCHFMKRTVTYLGHHISENQICPLNSNVAAINEYPPPTDKKTLRRFLGKINFYHRFIPDRTKNLDPFYELLKKDKSFEWSAEKQAAFIRIKEIITSELVLHIFDPNKKTILITDASDIGIGAVLKQEHDGQEVPVGYFSRKLLKHQRNYVVTEKEALAIIEAVEYWHHYLYGRKFTIRTDHKPLKYINTYKRTNTRVMNWAMRLNQYEFDIGYIKGETNQEADFLSRNPNFEVNVLSLDRLEVLHRPLLQNPPRGCVKYNNHIVKVRKDVRRYYLPEQEALQELRRIHEEKGHLGMVKTNQHFALKYFANKQNDLVMKIVNGCDICKRAKKQIRKYGEIDKLGPATEPLQIVHIDTKGGFSEPRVKTRYLHIAIDAFSRFIWIRASQHQNSQDYLNLLQQIEEDGTPSKIVTDRYGAFKSDRFRSVLRTKSIVLVHTPTAHPQSNGLVERVGQTIVEKLRCKRLIDETRSWSALAKEVADEYNHTIHSSTKFTPAYLLAGRDPDEIYHGHDLNNDRKSALEHSQSAYQKEFKRIVQKQIPWKLKLGDMVYADLADELNKKKLDPVYRGPFKVINKISEVMFEIKLPDRTEKVHIGKLKPFVPAVGIGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L900</accession>
    <name>A0A922L900_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neuroendocrine protein 7B2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SCG5</name>
        <name evidence="11" type="ORF">DERF_008272</name>
        <name evidence="10" type="ORF">HUG17_2440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 7B2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L900"/>
    <dbReference type="OrthoDB" id="9922675at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046883">
        <property type="term" value="P:regulation of hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007945">
        <property type="entry name" value="Secretogranin_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12738">
        <property type="entry name" value="NEUROENDOCRINE PROTEIN 7B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12738:SF0">
        <property type="entry name" value="NEUROENDOCRINE PROTEIN 7B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05281">
        <property type="entry name" value="Secretogranin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324750" description="Neuroendocrine protein 7B2" evidence="9">
        <location>
            <begin position="20"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7638407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9517617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="321" mass="36804" checksum="8D5FABECEB900942" modified="2023-02-22" version="1">MKNCLVVSLLLLITFFGQNNNILCGQYFGINDLEYRIPNSLLNNFYGRIDEDQQQQQIHPQQPYVIVNPVDFQAKDSYPLYQSSDFNNYRIRKDLSEQQQQQQSNELLNRYHLQTRDDILLPREPVPRKEFLEHSSLYGHQYVQGGAGEGSQHLKPDGSIQNVQVIKSDSVLPAYCNPPNPCPVGYTAEDGCLEDFDNSADYSKEYQASQECMCDSEHMFNCPGNTDENELETLARSIQNEGIELDSTIDKIMDTMDTTAKDHKVVAKKYFQKRSKKSIVKRSIDEIKNNNKSFKQENPFLVGEKLPVVAKKSPQTAKIHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9R9</accession>
    <name>A0A922L9R9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001781</name>
        <name evidence="2" type="ORF">HUG17_7609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
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    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
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        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="114"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
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                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
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        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <tissue evidence="11">Whole organism</tissue>
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    </reference>
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            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:29999"/>
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            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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    <comment type="catalytic activity">
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    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="PANTHER" id="PTHR47634:SF9">
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9520810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2192" mass="247781" checksum="B57CDEF6B4F8C7B8" modified="2023-02-22" version="1">MDRFQDRAQKYFRSAKCWWIGSGNNTNNNMTNNNNNTANNNNNLSTKSTPIMMKHDAKNGHENKTKFYPNNDDDDDNDDDDDNGKKKNNIIRSSCIDMDNVRHQRPLSPTIAIFDQFQKNNHNNNNKQFRHQYEYRIQPQQPPQHPIPSSSSSSYRKNDGSDNENDDDEDDDDDDDDTDDDDDTDIDIDNKIELLKYSTPISVAPTIQEQIQEPNFAPCRRYQSRPSRIHNLINDEQHQQQSLQKKYQQQQQRQQQKSNQFLTVKLAIKQSSQTNHQSNQQQQQQQQQQQQQQQQPPKHRKRTKRRNRKPLKLDQQSMDPYLKNREPQFDELVLRFEREKCEKLLWNNDKTNESIIITNNDGDDEEIKNSNAGDDDDDFLCSSSYDYHLRAPDYQQQQQQQKSIATTTTAAATTMTTLKPSSINITASDRRQQLSRLYSFDHRDRDDDQTILQERNQFDDQQDHNKEDYLIQEEPADMDDMNDNDRFMESTYHSRSSYQQQQQQQQTSPWLRYPTAATTATTRQRPPNIERSNTEPASQTIMVTIDTPSSSTHHPNNNNVGQQQQQSPLHTTQHSPIRRSPLDNTSNVNIGNNNGSMMRQSSFDHHYLAPTLAYPSHHQYPSSLSLHHHQHHNHYLHNNSYGQQQQQMKSPSLYGTSSSASSLLLMMANNNNHDNSIQLHGGGCHYESTSSISSNNSNCSAAAAAAYLYPPHSSGNNSISPSGSRILPKVNFTKNPYLMLEDNSPGGANNRLSMSGSPGGSGPRAPPIMASQSVDEYSTGLIDPGNLALMMERSSLENLPLPSNGSTPQFFLNSSSSSSTQQQIQCGNNVNNNNNNSSSTSSWKQDDYCSIGGDSGTGSGGTTTSLGNRRGSTRSGHFPINTHHYHHPPVQSSYSLDVPTLDRYGNVHYHNNSHHHHHQQQQQQSYQYGSGSYSQYPSQSQLNFTQLQPSSSPCSYRDLTQTSILSQTTTTAPGNCSSSSTRRLSPKDFQNFLQQQQQQQQQQNQSPSHSSSPINQQQQQSSLTTTTTTMTTNDDPNFSQQRRRQLPTIKSLPLLINNNKTGATSITNEDAQQQRQRLFRRSPQHPRLSRLNSFHHHQQLHQQQQLQQTTISGGANGANNNSRLSVPSLRLTHSFDDDHHQHLQHQLQPQLSSTSTIINNNNNLMTEPNRHSSPTTPGAWINASPGYHQTIVTQQSSSSSSITISLTTGSSQHHYSSIYHLHRLSSFDQQHQQQQQQMIRKQYSVDSVDYKPSTTATTMMMTQFPLLGFSPPINQSINYQNRPSPYSDSSISINIENDVESTIKMAKQLLQQQQQRQQLQQQHQQHSYGQQQMTMGIKTGRKLPTIFSSSSSQSAYFWRHPRKSLSLEDAAIGSGSPDIYPNQLLHNARNQTFQQQQQPLEVKSDICGPHLSTQASLSSNSSAGCGPGSDPTSSCGEPKSSPSANIIDQDEEDIELISYLCRRYIKEQKDVDEDQEQEDLIDYKLGGYHPLKIFDVLNGRYSAILKLGWGHFSTKIFVAIKVVKSAGQYTETAHDEITLLMRVRKADPDHNQEIVQMYDSFQIIGINGSHVCMVFEVLGCTLLDLIIKSQYNGIPLENVRSIIKQVLRGLHYLHHTCGIIHTDLKPENVLLVGSHEMAQKLALKALYRIHHNVPLPLSYKSNAPIAQLEAEYRRIKKKFRRKNKKKAKKLANIKSNSSSTTSSTVTSGSNMTNVVNASNVDDGQADNDDSNSIREEDESICSRPNNNSSNQENLLMPEFAWVYDPSYIKYYEGVGYPEFAAEILESAPRLVRKEIQSGKNSEPAFEICDVRVKIGDLGNACWVDHHYSEDIQTRQYRSPEVILRAGYGPSADVWSVACLAFELATGDYLFDPRSTSSTTRDEDHIARMMELLGPLPREVIFAGSRRQKFFDNQGRFLKRLFEDYDIYSLLVNNHKFPKPVANIFADFLETLLNYNPTIRPTALECLKHPFMICDYNYSSMIEMAAARTASRNQNNDGGGNSSDHHHHSNNTSYNSTDDNDNDDDESESRTATDQHTESHDHCDRGSEISRSGCSNAGRSPTTYSQDDNQASVAAAAGSSSSSYNKKPICCLSTATTDNNNDHDDDDENNEKDIDDNDNRGNNHHVHINGTKFEKCFTNHHHNSNSMKKNSMYMVNNNNQKNLAKNSKIHGGQLLINNDGNNSATSESDADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAS3</accession>
    <name>A0A922LAS3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_002719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAS3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14699">
        <property type="entry name" value="bZIP_Fos_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="362"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9528804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="435" mass="49164" checksum="740008EA629A776C" modified="2023-02-22" version="1">MSDFFEIQQQQQQQYMMDMNPIDEDINNVPITSGDLLSNPGQDYYINNNNFSHQLDMAQFSNINCPTANNGNNQVDLGAISAQPVVINNTDYYYNDINWNYSPISEMISTSPQSTASNFSTPSIVSDYANQTQLPQYYPFDYMVSDISSQNQSNVTMDWDHYNNDNIDLSFFNQDVIPLPIPSASMSDAQSTLVNPESMNQQQQIKPTAVNKPVNPKSNSNQSISEMISTSPQSTASNFSTPSIVSDYAVQTQLPQYYPFNYMVSDVSSQIQSNVTKDWDHYNNDNIDLSFFNQDVIPLPISSASMSDAQSTLVNTESMKQQQQIKPTAANKPVKPKSNSNQSSDDLARKLELKRERNRVAARKCRNKKLQLIEEYKKTNAQLQKDIEESEALLRKINARKFELRAALLNALNSYPLQSLTPSTVLQECNEQSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB19</accession>
    <name>A0A922LB19_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidylinositol 4-kinase type 2</fullName>
            <ecNumber evidence="9">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PI4K2B</name>
        <name evidence="12" type="ORF">DERF_001318</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="9"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB19"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="241"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9527292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="595" mass="68370" checksum="4478768168D9D2EA" modified="2023-02-22" version="1">MYIDLYNDDDDNNTNRTTSNNVQQLVNNNNENNHMNDSNLLIQPLSINNNTTTPAANNEDSLLHNHNDSSSTSATIQNNQNLNSCCMVERLISIPNDDEDDNDDDRTNNDDDDVIVQNCNHHHTDNNESLIIPNGDCIIGNGCITTIQCSAATTTTTILPDVACVSTSTSSSIVGQQQSNLQQHNISMIHSTSYGSNQDNENQPLLRRFDNDSLQVINNFFPDDQEFNQITREVEQSIENGFLPKRISQGSSGSYFVKNRDGTKIVGVFKPKDEEPYGRLNPKWTKWMHKLCCPCCFGRSCLVPNQGYLSEAGAWIVDRKLQLNIVPKTRIVKLASETFNYSAIDRAKSRTKKNVTERFPKVGRHFNRIGLPPKVGSLQKYVENYEDACIWIRKAETLSDENVLDSFQLEFEKLVVLDYIIRNTDRGNDNWLVKQEFDDDGRLVFIKIAAIDNGLAFPFKHPDEWRAYPYYWAWLSFAKKPFSEEICRLILTQLSDMNFVQELCDELWNLFSTDKGFDRNIYEKQMSVMRGQILNLTQALKDRKTPQQLINMPAIIMEKSRIAVKGRFRTMKDNFTQTFQRKNTILFIVLKYFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB97</accession>
    <name>A0A922LB97_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gustatory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB97"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9530321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="73941" checksum="3D5E072403BAAB47" modified="2023-02-22" version="1">MDVDYEQKIHSPYIRSFVQFHGLMGMQLSSIHWHDWCSLLRFLFNISLNGFVFYGTYVEAYDKPDEINKASYLYKHFLQACLGIFYPLVYGISIICLLVYGQQIIKHLDSSAFFIINRNCQSNHHHSKVFIFYIIIILIWDQHYLLHGLHELLKLDLPHLYVVMFSVHFKDISQLINWYILFYHQLIIFYSLQQIVRKFNSEPANKSMRKTENNFSIEKRLFNSIKNLSENNRRLQYYCSYLLFGILIQQTNYVIDFLTLQILRPSTLHIGLSNIIAHTLRLSLGFFLVLINHRNIRLFDQIDKYFRSKCIGKPHHHNRTLRYGKYIHLQIYRSFYKLSVFTWLDIDLSLIPHIRTFVQFHRLMGVQLSSIQWYDWRSLFTLLFNLLLNGFIIYGIYIESNEKHDNVNKSIYLYEHFLQASITHKIIFHYDKIYGQLSTTNKSSSIRKTGNNFSIEKRLFNSIKNLSVHNRHIQYYLSYLLFGILIEQTNSIIHFLTFFIVDPRRTSIGLSNIIAQTLRNCLCFFLVQLNQRNICLFDQIDRHFRSKCIANHHHHHHRDNSITTLRYSKYNQLQIYRQYHQLSVFQWLNIDSSVLVQLFFFSLSYVLIISQTTKLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LC70</accession>
    <name>A0A922LC70_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_006553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9523000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="814"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="1328"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9523000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1610" mass="187404" checksum="75094EF17A82E9D3" modified="2023-02-22" version="1">MATTKSKIKQLNENLEQVYVELVNLQSEVKHPELQEDKEYLKQKLMNLKTKLAELMVLREEFAGLGYPNLPGIERGTSCHLLVSEISKELGSNITETVASGRIASVPISTETRITDQQLVRDSIASAPPIIFSSFAGPSPIYTSKQSETILTTTKPIITKPANIFKSIFNPSKIPIFAKTTAQYQFQNPPVYSGKIQNIQTMDYANITEDEQQPSTSHQDPLIYPLQIEEDIQPVSRYVKPFNLKWADKVPKFDGSFINFHSFINTFNHHVHSTDCDDSGKLLILREKLDPKSLQLIAGIREPNYLMAYNIIVRHYSESYPLQQKLKAKVQSLPEIRFWYQTEEMRSNLAVIKDVYNVLEQSESNRSFLETDFYFIVASKFPRDAIKDLMQKFGSKLTVKQYLFNLTMYIEQNEQQQTILSRTNYMTIRSNQPFRRSQPPRQNPFSRNPNPNRFNRNQPTRFNNPWSFSISKRQQNNQPKITFPGESTENSSTSLPLRIKYDNPTPSTSQTYPKILQQRSGTDSNSNQYKTNKCFFCGKNHIPINCDKPIMEKKRILSSQKRCLRCFSSFHIINQCPLRFTCRLCRGNHNTSICENKERYPIHNVNHIKKKEEGPTEIEVLLNDSQKSGLYDPGASHSFINKTQCKNLKSSIDPYCSKVKQAVSYSKISGKTKIKVKVGNIEEDHIFFVIPEIEQIIFGIDFIDKFKIIRLPYGEMFQYLDDELIPLKTNEEFKENDVPTAKVIQMEKIKDLQPQIQEVMRNYSDVFTDCAEIGRVRDDYCYINLKNNVPINLRPYRVSPVDQQIIDEQIEKLLEKKLIKPSVSNYSFPIVLADKKDEGKKTRLCVDYRKLNEVTITESYPMPLIQDIENKLYDASVFTTFDISAGFHHIPMAPEDCHKTAFVTMNEHYEWLVMPFGLKNAPAVFQRIIFKILKANELTKFAHNYIDDIIVFSKDLEEHIQHLEKILLVFRKERIILKFSKCKFASEEVNYLGHNIQCNQIRPLHSNKQSILSMHPPNDLKSLRRFIGKLNFYQRFIPNRTELLAPLYELLKKDVKFIWTEETDQAFKRAIEILSSDLVLGIFNYSKTTILISDASNIGIGAVLKQKETELDDDKTMVTIGYFSKKLHPYQINYSATEKECLAIIEALQFWHHYLYGNSFIIRTDHKPLKFINSTKTPNTRIMNWALKLSQYNYKIEYIPGKDNIEADCLSRDPNFQVNLLTLEEISNLQDFIQEPPPNCIRYNGLYVRYTNGRIRYYIPEDFAKYMIEYFHKVQGHIGQKQTALHFSQNYYTTNQNQIIHEIVYNCAICLQAKRPRKKLGKLSQIGPAKKPFEYVHIDTIGGLRDQGTTNRYFHVAIDAFTRYVWGLNSKTQGTNDFIKLIEEVKKDGIPESVVCDRYPALNSRRFREYLQENLADIIYIPVTHPATNGMVERFVQTFVERVRCKKIEHPNRSWSHFATDILKQYNSTVHTVTRFPPCFLLLGEDTYNIYAGESVYDLEDYRRTAFINSLIDHERNRSYYDKRRKNWQFTIGDWVFAKLADDLNRNKLDPRFEGPFEIIERSSDLVYVIDVSGNAVMVHVENLKPSTTRTGYSGFRIFDEEVEEESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCR4</accession>
    <name>A0A922LCR4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ELMO domain-containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ELMOD3</name>
        <name evidence="2" type="ORF">DERF_003852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCR4"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF2">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="106"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9530007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="297" mass="35077" checksum="BFCE4CB7BEDB0FE9" modified="2023-02-22" version="1">MSNEWDDIVCLPIIDISNNYNKNDVSIEQDSIDFITYQQLHSHVFSIDLGGPHDQKIHFEKKCNFLMKILRYMLFWKTYELKPHFVAEGNRIIRIAGQTFDNRNKLHIRCLYTIFAKLTGNVVLGMKRFGQHWEEIGFQGSDPSTDFRGVGLLGLFQLTFFVITPKICQLSKEIYDLSMDQVQHYPFAITSMNITQIVLQMLRDGSLNCFINRSDSVLIIFNQFYYGTFLYFHKIWKKDKKTIMDIGYVLKDLRYYVRNNLKKILDDLVNYQSMEMNKPGHQENFTNIINIDDRNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCT9</accession>
    <name>A0A922LCT9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCT9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9530157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="99" mass="11894" checksum="B94E59CB65E31A75" modified="2023-02-22" version="1">MPQIVQSTIKTRNLSISGIFVDLHQLVAMNDWLFHYLIRTFKHEKRKQAKFWIHPKRPRNHESDMRPLSSSKIWDQNLKRQDSSEKPKLLAQAPRYEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCY7</accession>
    <name>A0A922LCY7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_001357</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCY7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="133"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="424"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="577"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="578"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="10">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9527335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="629" mass="73195" checksum="40D36289C3E49D60" modified="2023-02-22" version="1">MTVETQLVMGCKCFKIGRRNPANEQYDESNYMADENGEPQMDDEQLQEQQQQEQQQEQQTPESTTTGKIGKKRKRSKEKRKHQKEKEKEKSKKHKSSKIQVTISRIPTTDVTPILSCKSDGSDTEKIIERIGYRLEKQIGKGGFGTVYKAIDLKTKQKVACKVMTVSTNRKDQLLIKKELFILHSVEHKHIIRVYKHFILQSSKSAHVYIFMQFADKSDLWNLVRKKLETGMKEKQARKMFKQITSAIEYLHRRNIAHRDIKLENILLDKKYNCLVTDFGLSIVVIQKEGRVVNAPNYCGTIPYMAPEIHLFLITKIIFDVLQADVWALGVVLYCMINQGQFPFSMDQDVMLQQQLSGQFQFTDKMSFKPDDRLIDLMTQIFQPNPLIRIRMVDLVQHPWLIDAPMDKNIPKLKTCEPKIMIDPPKQQQQQQQQQQTAPEHQSPPSLQGQQQNSQEKQKLDNITGQIVKQNLKTMMMMMMNVGDKKGGGGGGGKQILEQQISPAMMMRMPIKKRMKMKKRMKVKVKLKKFQRSPMMMKMKHQPKSPFQQKQQQQQPPYMMPMLMKGKSMYPPMFMDKQQQQQQQFPPFYQQQPFPPFYQQQQQQQQQLSSYSSGSSATSTMSSDTSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LD09</accession>
    <name>A0A922LD09_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger CCHC domain-containing protein 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ZCCHC24</name>
        <name evidence="6" type="ORF">DERF_001526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LD09"/>
    <dbReference type="OrthoDB" id="10038672at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057809">
        <property type="entry name" value="ZCCHC24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033446">
        <property type="entry name" value="ZCCHC24_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23490">
        <property type="entry name" value="ZCCHC24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17180">
        <property type="entry name" value="Zn_ribbon_3CxxC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="5">
        <location>
            <begin position="241"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9527515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="351" mass="38727" checksum="E93151BF656224C6" modified="2023-02-22" version="1">MNTTEDQNTNVNHHLHHHHHQHLQHPFHSYPPVTSTSIQQSSTQQQQHMTIMNQIVPGIHHHPYLHTQSTDPTSSFIAAAVAASAAAAAASSHPHPYNPATIFLSPTADSSPSTPSTTISTFPLQTAQLYPTSIAATQQSSLQPSHTSGHPTIVDLSQISLDQLLDHTPKLLTDHLNAHHHHHHHHQTSLLHESPQTFGLTTQPTTTTTMPTAATSQPPIIDLSSLTGKIDGLTPYQGKKRCFGEFKCPSCHRKWMSGNSWANSGQMCVRCRIMVYPHKQRPLDKPDGLDVSDQSKEHPQHLCQKCTQLGYYCRQRIQTDSSSPISNADDDTNISDSIADIQPSIVDEVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LD43</accession>
    <name>A0A922LD43_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Intraflagellar transport protein 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">IFT57</name>
        <name evidence="7" type="ORF">DERF_001852</name>
        <name evidence="6" type="ORF">HUG17_6849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT57 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LD43"/>
    <dbReference type="OrthoDB" id="423881at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019530">
        <property type="entry name" value="Intra-flagellar_transport_57"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16011">
        <property type="entry name" value="IFT57/HIPPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16011:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 57 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10498">
        <property type="entry name" value="IFT57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="336"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7636643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9527860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="426" mass="49197" checksum="566573C02B92A62E" modified="2023-02-22" version="1">MPGVTKNSAKSISSEEISEELLEKMHELNEKLLALDYTKEFVSNFKCPPIHRYFFSKQINQAQQFFAFCCMSSYLLNKLNDGRQQIQVDSFDDPNLTIDKIVGASQAYGVGDVSKSRLKLGYGAEVIALLSTLTDKLFLERYKSNEVHIEIIVRSGDGIQIESEDDDDEYIDDDEQENEIILEEEFEDYLETESDLVVHEDDNEEWQDASLESNHQQQLRQQMIQAARIDLSEWKLELERILPQMNAHRFMKNQSKNRMTMLTTANDISNEWRIHLQAARRHHTNIESIFSQTEGMLTGIAAEMKTALDKIAAKENYLHQNCNTILAEWINVRQRAIELKQSLDQAESELEARSLRLQELNDEDRSTKQSIEEYSLRMTDSSPLAEAKKAREMLKQEMTRISLQIGVAIQILVRHVSLHSSYCSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HFH1</accession>
    <name>A0A922HFH1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coiled-coil and interaction region of P66A and P66B with MBD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GATAD2A</name>
        <name evidence="8" type="ORF">DERF_015868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040386">
        <property type="entry name" value="P66"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032346">
        <property type="entry name" value="P66_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455:SF7">
        <property type="entry name" value="SIMJANG, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR P66-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16563">
        <property type="entry name" value="P66_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional repressor p66 coiled-coil MBD2-interaction" evidence="7">
        <location>
            <begin position="451"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="633"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="683"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="986"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1105"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1182"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1229"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1274"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="506"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="683"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="779"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="989"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1192"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1229"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1239"/>
            <end position="1249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9491134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1300" mass="141040" checksum="059A41A399105FEE" modified="2023-02-22" version="1">MSSKDETLTNETTDNVVEVMKSTETTSIIIDDDDNKINEKDDDDDEINQQKSDDDNEQQMLIDDQSDCCDNNNIGETLTNDQPDVDDDDDNVEQEIIENNGDTIIDDQTVDDDNVQDEKEEEKETKKSPLQSENDTINDDNDNNQVQNKLNPSNDDDDDKAKTVIDQPNESISINGTIDDNETDEIQNNRHQQQDENKNDDEDESIDSKDNIDDDDKVMESDKPEIKEEEQIEAKQNQHADDDEEEEEGSPQMLTDVDNEMKDLTVPKIEIKEDDKETEEKEKELNKSTSSKTIDIGQDEMATLDLSKSLPNGSQTKIRTKEQRQPLSESYVNTPMTRSQKRARSNNNTTTTNTSTSIVEDLSISGMKRQNTTTLPYSNGDSNSLDNDEIDDNDDKSNHNNNNDNDNPIMLKRKKRNSNDIYDMINQNEQQQQSLYNENIDDDDVREESMAKLKLIRCLKQRLFNEEMKLLFLKKIRHSQLKENISQQQQQQQAMDSTVTLMNTNQQQQQHGLGHGNQQQQQNHPNRLQQQQQQQQYPSHHNLTNSSASAAAVAAATLANNLSSIGGLNLACLQREFAQHLLAQHQNHSSTTSSYSAAGLNSVLNFSMPTSGSGSHGHHKNMANLINNNVAHSNHHLSSTNTGIHHTPAHAGSNTKNYHSSNSAVAAAAAAAAAALNFSTNHHQQMQPMQAHMTKSSSGNSSGSSHHGLSSSAKTPSPAHLNHPTYHHGITAGRSPYNYNPLAAPPPPPPPSLTKHRSNSGSSSSGIGHPDSPHTNLNAAHASSMKSTTSSSSSNNRAISSPNMAYPDLRHSSSSKHNQIIPPNVPSPVSNHQVVDGNSGNVVLTKEQILLQKQLATLKQVMRKHVEKPPQPKMIPSEMHFIPNPSNPEFIYYVGLETVVNYLTGSNQMPQPPEPFECVQCGTDFTPVWKWKDRSNPAKPSVICERCVSKNMKKIISDDYQKEVSSYAKTFEEIEKHLTTATVAAASIPTPPPPTLQPQPPPSPATVTSHRTMSPASIPGNSNVPNQPQQSSSSSSRQSSSNHLVSAANSLFGGSSAASNNPAVMAAAAAANFNLQQAHSQNSPLSSLSPSQMAAMAALLMPQANPQLPPQQQSTPPVAHSSSTRSSTASSSGNFGPSSLFGGAATNSAAAALTLLQQLQSFPKINQAQSLLLAQQLLAASTPLPPSPQPPASSASSSAAGNPNASAMAQLLSFPNFLYSSLLAASLTNNQQQQPQHKSSSSSSSSSGSTAMALNAAAAAAAASIPRQLLMEMLPGASGGSGGHHSGRSSSGHSQHNYKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HFJ6</accession>
    <name>A0A922HFJ6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mannanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_015884</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HFJ6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000050">
        <property type="entry name" value="Beta-mannosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000060">
        <property type="entry name" value="Probable beta-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="12">
        <location>
            <begin position="33"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="11">
        <location>
            <begin position="832"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9491152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="903" mass="105103" checksum="33FD92D004BB43C5" modified="2023-02-22" version="1">MNHTAIIIVLELFTIIINTITAVIIHPLDGNDWNVFDANKRSNSLPAKVPGTIYSDLVNAGILDELYNDFNDVKYRWVSYANWTYVKSFDFPKQLLTYDQIYLTCHGLDTIANVTLNGYQLGSVDNQFIRYRFLVKNLLKTQQNVIQISFTSAPVYARDYFLRKEYPIPPVCPPESQHGECHPNFIRKMQASFSWDWGPAFPTQGIWQPIAIEAYDNVLIRSISVNTVYEQQSNQWLLNATVWMESRPKASINANLTLSLADQVLIVKEFKTQFNSDGEAFVNTFVMIPKEMAIKPWFPNGLGDQILYRLSATIHTGHEMINKQVAIGFRTIELVQDRLNASVEAYSFYFRVNGVPIFAKGSNWIPAHVLSENVKREYVQFLLWSAKVANMNMLRVWGGGIYESDYFYQLADEYGILIWQDMMFACALYPTDPKFIQSVSTEIRQQIRRLHHHPSIALWAGNNENEMAIAGMWWIELAQHLADYKRDYLQLYIDTIMPIILNEDNSRPFVSSSPSNGIVSPRENYISTMPQNNRYGDNHHYIMFGDAWDWRTAPSAKFVSEYGFQSLPSLELLHKYLSVEYLKYPFNEGLTHREHQMNGLAYLIGFMDQHLPLPKNVSVPSIEHLDDFIYMSQIFQSMAIKIQTEFYRRNRRINYHNGNGFTMGALYWQLNNIWPGFSWTSIEYEGKWKMLHYYAKRMFDDLLVDVYEDEDNLYVIIVRDDHSHVADFNVDIEIYEWSKQEPISMQRINCLTNPFDITMAFKVNMNEFLHKSRCDNRDNCFINVRLNGTINGQQLMRDNFLLLGHLKNAKLMNDPKIFLQKIDGPFQRGGSHVYDIELITDKIAPFIWLDLVNDSSLFGIFSDNGFHLINRQKLQIFISKDIPKEDIASSLRIKTINNLVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HHA6</accession>
    <name>A0A922HHA6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="516"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1294" mass="147846" checksum="E43316653AEE9484" modified="2023-02-22" version="1">MSRLHQNANASPTALSQFLTFCDDNKIDIGIISEPPLRNNIPSINSKFKPMYVTNQLQLPTNNQRITRRQSASNNQSTSNNDQSNNNNQPAVRACIILLNPSLSSIIITHLSNSDFIVANINNIIIASVYSEPNGNINNTINCVINTTNYANNNKCIIAGDFNAKSIYWGEPTSDERGHEIMLTIVQCNLHILNEGNRPTFDTVRGQRRLTSCIDLTLVNDNLLDQINNWHIHDEIHLSDHRPITFTITDQCIDHQQNQSTTKWNTTNINWTEWSSDIEYQLHDHNLSATTINNINDTNELDLAVTIITVSIQFACNLHCGKYRHKRIRPAKWTSNQSLLDITKKQKAIYRKIRRCHNPFTIERLKNEYMIARQQYRDISQSLKNDDFNKYLNGQGPENCYQKVCRMLKNSDVMVARTIEGTNSPIESTTKLVNSLFPDDDFDDSNEQHEIRQFTKKWLEKNKNNTGVTAVSLLELNNVIHKFRDGKAPGFDGISPRILKNLWLSFPDLLLALYNACLRLKYVPYLWKSSIIRILPKPGRDDYSKTNAYRPIGLISVLGKVLERIMSIRITNHLISNGHMSDYQYGFIAGKSTDHALLNLHNDLESAITRFKHVCLISLDIRGAFDHTWHPFIINQLINYRAPKYLIQLIDAYQNDRRITASYGGVTCNKTTNRGTVQGSILGPLMWNLVVNDLLRKNFGLDVKIQAYADDVTMVVACDCIKYMPVKINKILEMAASWGRKCKLTFSESKTKIMYVSKKIARPIYPPVRMNGAIIDPVKETKILGIIIDHKLDYRPHIKYAIAKATRINRAVTGIARKSHGLSPQVLRMIYHSITEPIMSYGALITGRAVKYQHIQKILRQMVTPMAQQAVKAYRSSSYISVTALADFPPIELFIGFRAAIATARTTGQYKYNDLPITVDINDDLNNNTTSKITTIIKEPSASPPLRIIIKSIKTTMGVGAAFMIFNSDNIIGVKHYRLAPYCMLQQADLFAIMKATNWINENSNNQTVYIITNNISTVQHINRIDRKNRQRLANEIIDKSIDNIVIAWNKVDKAEPWYHRLKKYAKITANNRSRDYDYTRMPISFVKKYEHNNMMISWNDRYLRDRFGTNIKKLCPNLHDARKFVPYVNNFVTQTLTGHGQFGAYLSKFDISNDKKCCCGFRFQSVQHLINDCQMLNHLRHDYRISINSTDDAREKTRLTAVFYGNIAMFADQHRRSIHRLHPPTKLTFPGGSRKSLCQLTSGGPGREARPKQQRDHTYTTIITRINPQATCGHAHQQSQGGPRKQPLLCAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HIY8</accession>
    <name>A0A922HIY8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tyrosine 3-monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_014635</name>
        <name evidence="10" type="ORF">HUG17_6573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7644211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HIY8"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004511">
        <property type="term" value="F:tyrosine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048066">
        <property type="term" value="P:developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006585">
        <property type="term" value="P:dopamine biosynthetic process from tyrosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.800.10:FF:000004">
        <property type="entry name" value="Tyrosine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018301">
        <property type="entry name" value="ArAA_hydroxylase_Fe/CU_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019773">
        <property type="entry name" value="Tyrosine_3-monooxygenase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF15">
        <property type="entry name" value="TYROSINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000336">
        <property type="entry name" value="TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00367">
        <property type="entry name" value="BH4_AAA_HYDROXYL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="9">
        <location>
            <begin position="170"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7644211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9493909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="521" mass="60145" checksum="050543C036864479" modified="2023-02-22" version="1">MSATGFKIMASLASANRLEKKFAIRSYSVEHGYPSRRRSLVDDAKFETQKNREAVRSWIEESRSASQDFDLSEEEVIVAEETRQKDGEQKTDDMLKRKNLMIALPANNGLDNLPRILRLMQATQATIEHLESRQNEKDRKCFDIFMSVMITPANLLTFMKSARQAGLGEVSLLREKLISVKDPWFPRHISDLDFCTHIMTKYEPELDSDHPGFSDAIYRARRLEIANIAFDYRYGNPIPRVKYTEEEIKTWGIVYKELLRLFPTHACSKHIEVFKLLEQECGYAPDNIPQLEDVSRFLKKRTGFTIRPAAGLLTARDFLASLAYRVFQTTQYMRHPSEPDHSPEPDCVHELLGHIPILADESFADFSQEIGLASLGASDEDLEKLATLYWFTVEFGLCRENGQIRAYGAGLLSSFGELKHSLSNKPELREFDPEKTAIQPYQDLDYQEIYFVAESFDDAKEKFRKYVADKLPRRFEVSYDPYTDRVHVIDSVEKMDRLVGKISNQIERLHSCSSKLRKIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HK00</accession>
    <name>A0A922HK00_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of nonsense transcripts upf2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">UPF2_2</name>
        <name evidence="5" type="ORF">DERF_015850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000014">
        <property type="entry name" value="Putative regulator of nonsense transcripts 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="96"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="519"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="724"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="423"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1229"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1306"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1015"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1065"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1118"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1315"/>
            <end position="1327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9491115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1366" mass="157667" checksum="06E8B8A7FE1A012C" modified="2023-02-22" version="1">MQKSEENEADNSATNQEKQEETVNHGEENKNNDKDDNNKSEENDKEQQQQEEQSIQEYIKELSERYKEKREKRYEHNVSNIEYPDEDLFVKLDTSIKKNTAFVKKIRNMTESNKDVIMKDLENLNLSRFISELATALVETKIKANEIGMFIQICSFLHLRYCDFAAHLFDAWNKNLPRKPSDQFNASKMRVDIKIFTELILSGIFTTKDSLPALGNLLTILTNADKETHKNISILVAFCRGYGVEFAGLYPRRQRMLAEKFQLQLPVCDFLSVERQRGVQTLLKDYYHSLIQHISKDRKYLFHLKNDMKRSLETRGEVSEALQEKWKTKSVEFEKLYQTATTFADLIDEEMPDIDTQALENDTMLMKNENVTAVLFDLNRFKENNPSIWDDEETRIFYEKLPDLKSLVPAMLYKDSLKDESTMATNNNEASGKENGESNDGNLPPASSSTEIETDQNLDLSKEDDLILTGDDTSIPDPKDVPLLNENDDVDPDSSTMKYDKNKIRIVKFNFNATKDQLDTYFSSLPNCVNCDLIDKAALHFATTFNTKNNRKKLVDVLIRVPRTRLDLLPFYGRFVAQLAPIMPSVSTELCIGLKNQFRYNFYKKDQVYIESKVKIVRFIGELVKFNLFSKTEALKILKTLLSDFHHHHIEMTCNLFEVCGRYLYRCPESHHMTNLLLQQMMRLKNHMYVNTRYETMIQNAYYSVTPEDKSAARNIQTKPVMHQYIEHLVYTELSRKTVSNVLKKLRRIDWNDKEINAFAIQSLASAWKVKCDNIPALASLLSNLSQHRSQTVLMVMDTVLENIRIGKQMNSLEYNQRRISTIKFFAECFNYNLVDSTLLFNVMYSLLIYGVDYNDAGKSPMDPPFNLMRLRLVAQILHICGHFLMSPAAKKKLDFFLFFFQRYYWLKKSYINSLPVEQIDQMALFYIDAIFADVLQFLRPKFKKAQSYQQSCELLEKRLKELAENVKDVLPNSNVSIKNVLTPSTNSSNMQPPINDGQLEPIKEDSENEIDENGGDKKKNDEKNLLKKDSNNNDGNNNVNCNPLNNDGDINSDNNSGSKGCVDGDYDNSDEEEIEDRSIGNIYNDGDGSPRPIMQKPVEQKDDYDDDNNNADMINTDPDDSDGDLDSNEDIDDEEEDDEDDDDGDDSDENQNNKSNDGRGGGLRIHPCEEDDLFQRDFERLMMENLTSRSQEVTQRMNVEIVIPIERDSDTNKARQLGSGYESSLFSLEPSTMSNNNKNQQSQETETKSFNFRVMTKNQKSNKPILRSIEVPADSDLVQNFLAREQAQKREKEQVKKLILGFNERREMEDQSPNTSNSSVGSIGNNVRSITDYQHNRSTGGGYYHHQHHYRGGGGGGVNYRRRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HK65</accession>
    <name>A0A922HK65_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acylaminoacyl-peptidase</fullName>
            <ecNumber evidence="5">3.4.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_016703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide.</text>
            <dbReference type="EC" id="3.4.19.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.1" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000010">
        <property type="protein sequence ID" value="KAH9490504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HK65"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045550">
        <property type="entry name" value="AARE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19283">
        <property type="entry name" value="APEH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylamino-acid-releasing enzyme N-terminal" evidence="9">
        <location>
            <begin position="195"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="523"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9490504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="741" mass="84283" checksum="055A6865E9CC433E" modified="2023-02-22" version="1">MENFRDRYNIDRLKSLYNEYSFKPIPTRVTFIDDNSSFESDPNFRPQTLKISYQFRDTYQVKTSCYNKIYCWDQSSGTYKNKGLPEEQSEYVPSFNVSLQATSLDGKRTVYLKSKSDSKSSKSEQFIVIYDKTGVCTTIDVKSLNDELQIIENLHMSSFVLNEDGNYLLCLAEIQDKSNKDESPSVSKEYNINSHEYKQSWGEKFSTIYHTSIALIDLQKSKCILLDKVGVSLCQPFFFKSGDSSILSIGCIGFKEVPYKLGLIYCTNRVSYLFGAKVVRDPFGSTNVEPEIYYGDSADLSIRSPRVYYSNGYDNKIVFLESNAGGAHDKAARLQYFDVETRKIRTIIDDKIKREVIKKEDGTVSYSDIGPIFSSGLPKNCFTKDGKYILFDSETPFYRKSFAVKMEDHSVQMLDFADSTQIIDVNHDWVCAIGSSINQLPLVYLGKFSESNTKMQIVDDRQVRILETISFGMFMLPSKHYENKYITAIWTSPKEMVNKSGPIVIIPHGGPHSHYACTYLQSVALYNELGLKTCLVNYVGSTGIDQEYVEALLGNVGTSDVQDLLDVIQYMITNHHADKDRIILNGGSHGGFLVTNISGQHPEMNFLACIARNPVIDISIMVGITDIPDWNVVEALGVKEFRSLSEIYPRNVDEMSQMYSKSPLAHIAKVKVPTLLLLGKEDLRVPFPPGLLYHRILKARGIETRCLVYDDVHDLYKINVDFDCFINVAKFIEKFIYYNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMG1</accession>
    <name>A0A922HMG1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMG1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="97" mass="10642" checksum="A556FECB6BAAC3DC" modified="2023-02-22" version="1">MISSSSSIMKTTATMISNKQKQQQQQRQPDVTIDFDVSVIPCIQGLLYSKINSCCYLHCNVPTLFATRHGNIIVSPTIDVLSIGSISKRCGGNRPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMV8</accession>
    <name>A0A922HMV8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TAOK1_2</name>
        <name evidence="11" type="ORF">DERF_013620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMV8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051234">
        <property type="entry name" value="TAO_STE20_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TAO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47167:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="150"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="474"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9497647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="609" mass="71898" checksum="BD1D425D4223B056" modified="2023-02-22" version="1">MDPKNQSAQQQQHQQPNYQNQQPLYGNIVNNYNNNGKSNSVASYNSRQSTSQVSICSQSSSTSSIPAANNCVADIDAYRNPMSIRRESTSSSTGAGGIPNQANRISPSNSSASINSTELGANNFATLRTTSIVTRQLKEHARDNQLQEQMSGYKRMRRQHQKAIMQLEDKCRQEFEEQQQRLDKEYDALLQQFKKDLEKQITKQQQELDKKLKVNATQQRKISKSMTNTQKDEFSRAQIQQKREFKCIKDRLKREYPHDEYKVRLEQVQKEQHLKLQKLQQQNEEYYNLEIRKFRRRKLILYHQLERDMLRDELNKRQGQLEQAHDMLMQHHDIFQDLQYQQQKAIHQLREEQIRNQHSIELANQQEYIDRRLKELRKKHAMEVKQQPKSLKQKELQIRKQFRETCKTQTLQYKAWKEQILSSTPKDEQKNVIKKLKEEQVRKLQILGEQYEQSISDMLQTQSIRLDEAQEQDQNELRNQLDQELESLRAFQSKIRSNAEAQRAKERSELEERVRIDKLKLEKKMEDERQQFQNERNERKRLLLERQAQEIEKFDLESTQMGFNALAIADASTEPYPQLLDNDDSASVSGSLLSLAHSNSATSFTHTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN50</accession>
    <name>A0A922HN50_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_016056</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN50"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001556">
        <property type="entry name" value="Bombsn_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00358">
        <property type="entry name" value="BOMBESINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9491328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="409" mass="48420" checksum="2D5A969D381F1C67" modified="2023-02-22" version="1">MALFCIPFTYTNYMLGRWIFPHFLCPIIPFFQVTAVSVSIWTLTIIGIDRFFAIIYPFRSMLWLKRHKITTIFSIWLFGASIASPLLFYSRIESFQYRGENYDDCREQFSNDGGRIYTIFIFLFTFFLPIMALIFVYARICIHLIRNTTVPGNPDQNRDKYCVNKKIKVIKMLVTIVVLFAMCWFPIHLFQLLVWFHPTIQNQKTTFSYYLYVGSYFVCHWLAMAHSFVNPFVYCFMSGNFRQSLGKTLSRCWPRLFQKNNSNYHSTTITLDPNQHNHHHHHQHINKNHNHDHDNRLSNTNFDHHHHHHNDNDNDHRNDDEEISLTQTQHSITTMILMATPPQYNNNHHHHHLSSHCIDHHHQQQQQQHLPSSSSAAAETTTTTTTAKMAIHQYHSSEQNHNNNDDDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN97</accession>
    <name>A0A922HN97_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN97"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="79" mass="9652" checksum="FFA9C3BD9AED990A" modified="2023-02-22" version="1">MFGCLAYWRVNDSMVASKFDYRGQKMIFVGYAQSWLGWLENENQYFHSIDVYEDSQNVLQKKCYNIIYEQRKIFFKKHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP02</accession>
    <name>A0A922HP02_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP02"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8119" checksum="8D735D122609BD4F" modified="2023-02-22" version="1" fragment="single">QRHKNQFHFVSGQSDINISRNDLFFISFIMTQIKGVLPGVTIPYMMGLTRRWVRSGATFGAASFISHYILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP64</accession>
    <name>A0A922HP64_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CAMK2G_1</name>
        <name evidence="12" type="ORF">DERF_012225</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP64"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14086">
        <property type="entry name" value="STKc_CaMKII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000009">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000001">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9501372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="502" mass="56689" checksum="442A54B90A5C68B5" modified="2023-02-22" version="1">MAISDSNYPYQHRQQNNHHHYLANNNHDNQHSNRKQRPQQQQQNNDYYQEFSHSVTINDVDNSAGFPGASYGSGAFSVVRRCVQKSTCLEFAAKIINTKKLSSRDFQKLEREAHIVAREYYSEADASHCIQQILESVNHCHMNNVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGEQQAWYGFAGTPGYLSPEVLKKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKNLINSMLTVNPAKRITAAEALKHPWICQRERVASTLHRQETVDCLKKFNARRKLKGAILTTMLATRNFSKSTDSSNTTLEDEDTKDCLLNQHGVERSRTVIMADSSQARLSNGGGSFEPRKQEVIKVTEQLLEAINTGDYDTYAKLCDPNITAFEPAALGNLVEVFGKNCKSINSTILNPSVHLLGDDAACIAYIRLTQYVDKQGVAHTQQSEETRVWLRKDGKWQNCHLHRSMRTDFSLIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPD4</accession>
    <name>A0A922HPD4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair endonuclease XPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ERCC4</name>
        <name evidence="13" type="ORF">DERF_014604</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPD4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="12">
        <location>
            <begin position="645"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="938"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="938"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9493876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="974" mass="111612" checksum="783A9C6F2A21B354" modified="2023-02-22" version="1">MDELLEFEHEALLNVLNQNSLTISSKGLLNDRLLFYLVRTYSNPCHLVFVIGTDEIEENSILFQIDEYLTQRSIIDDEFERPKKISYASYKTQERHDMYLAGGVIFITTRILIVDMLTNRVPMSAISGIIIANAHRVLKDYYISFILRLYRLSNKTGFITALSQNASSFFGTFGQLEKCMRKLFVSHLYLWPRFQATILNSLTSRKQPKVSEFRIEMTPVMKEIQFSFLDLISSSIKELIKMENVGYFFDSTNTDEERSLNTISVVANNFNKLIRLNLDSVWYNLSLKARRTIREIQLLKSLLFHLTELDSVTFYGEIKHQMDSYDPTIHTVDWLHRPAATTLYDLTAKRIFQQNSNGEKVFHVEINPKLEALIQHLKDIEQQIVNNKKDIHGDDKIVDIIIVVENSYSIRQIERFLDKGRDVVIEELKQKAELFANGKKIEIVSKVIKTKSNTENDDDNDDGDGIIEFEDQLTLTQLLCPIESHETSIVRRHQSYQIHYYEWSNDNNCGLGLKHLLQTLRPYYVIIYEAEMCVIRQIELYQALYGQPNEPEIEVSFFVFDGSVEEQRYLRRLQVEKKSFEKLIQEKSRLPSHKENEGTVGEHPDLIRGKPTLLHPDEYIERINTRLGGMVNNQKKLSSSSSNSCVLIDLREFRSALPSFIHKIGIDLIPVTLEIGDYIITPECCIERKSIPDLLKSLSDGRLYSQTQIMTRHYRKSLLLIEFPEDSFSFNSRIWGNAFLFSQISKESRPDPLVQLSILTIQFPLLRLIWSPSPNFTADIINELKNGKDEPNKDKDIIRLNLEQDQQLPMECITDRFDIETKEFLLCLPGITTQNVYCIMNEFKSIINLVEQSIEVLTEKMGSGHHAKLLYNALHSPITLGVDTQQSKQPKETKRFAYVAQFVASAPAVHSICPVACVVQSSATWAFQSCSTGGSNSGAAIGSTGSPPKSVSNFAGRSDDKPISCSFSCCSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPJ0</accession>
    <name>A0A922HPJ0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPJ0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="122" mass="14456" checksum="8C3F3DABD937444C" modified="2023-02-22" version="1">MILFSGGRQYTYIHIQNDECEFCIMNTYEHNRMALSQWRIIDDDDDDDDDDDVVLFKLIVESNDDIVVVLMVKKICLDKKKKRWPSIQNVIPRLTLPRLALIRYNAVQLPYITLHCYVVYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQM1</accession>
    <name>A0A922HQM1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_013007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9496988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQM1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037747550" description="Sushi domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="43"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="5">
        <location>
            <begin position="406"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9496988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="632" mass="72673" checksum="08FE74A72D6DCA6F" modified="2023-02-22" version="1">MMIERIISLQFILIILLQIQRYKSSSSSLLESINNSSIVTGTCSRPNLPPTGRIRFASMEKVKFAENETIYILCEENQFPHQAQKRKCHHGRWLGKQARCGKAVVTKMNLLEATSCSELDQPLLLSVNLTQVDETPYPLPPNSFHFTRVPDKTPLSVIGSDCYHWYMQFEQPVEMQYLLIDINIKKEDSIKKDRPKIDIKIKNRKCQLEHTSYQVIEQDEIFGNYFFCDLYENITIKNNSDYNTTTATTTMMMLDDDIIKTDNLEMIIQIKGNRSVGLEAVFIGETYKKILKHLGNKSNIDCGKPEMKRTGVLEQIDLSHIKLRCNDSFIFLQTTSTTMPGMLLMMMNIKSIILFFLIVLLFVIIIISFELLKCGTNGLWQGEFPVCTPKKTCSKSEIFDTLNPTIQLEQIGNVYWFNESEWFAIEHTWIHYTCSNFDGIMVGKSERTCRGGHWTNKVPHCTTALNSGSVTISIIIIILVILIAVFSLIVYLSIRAHGKKINRKLESAKYELEEKALNKQISASSDGYYSDIGLETIYEDCKEIYTVPDYEMAEDIRYDIDPARRIQPKLLPLPFSSSSSQQQQQQPSNRLSEQIQYQSMEPEYLAMTEGTLNRPKTRPPLTPTYYNDDVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRE9</accession>
    <name>A0A922HRE9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRE9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="709"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="789"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="855"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="898" mass="104096" checksum="FD28DD2851F540B4" modified="2023-02-22" version="1">MRRSDKKRSKHDNIPDNEFRLFNNQATSSTTTTNNPFDNDSLMSSRQFYNQTAMNYPEPSAPPPESDNNPVSSEYTPLLENFTERFINRSQGPVLGVGVIDTTTTSSSSAMTTTTTNSNLAPQQSISTVISPVVPPELLLIHYQQSPFNPNLVESDISSFSSFDGDNNNVQNEHNQRGQQIPSSPIIEWTNGCFTKFRIYFCQTFWYLSQTILIISLIAFNFGSTFVPSIYSSLVITSNFSGHTNTSHTNRLVVFDFFALTTIQLSMAILSLIGSLILLYSASRVIHRLRRRVHLRNLKQITRTATNNLVQSLSSATAMATTNEKISDSELTTTIMTTEMIVFETLGSTMARTFSFIMLLHQFCLCSIYVHLIYDYFDMLISSSVSILSSEWIDYLDINGERKWYLNHLVVGSIWLTLIVVIVVALATTSFVWSRRRRDWRTIQYTRLFLLWIIKISGIIIGFIFIIIITFVGIHLYLKQNLQINNEILLNKINITNQSSIGYVPNPVPVFDTFLNDWYASLFGAIPLLLMPFHLNEILIMLMYSRYDYHYYRRRLQISDNDDIYGQNNDNGDNYNDGDQQQRRRLITAQQQMMNYQTIQRYPDILSGIRSPPPTPSQPPAPIANEESCDPLLYLASIQSMNRSVISSFFFRSFSTIRNWFIIIIFFIFLFQIIMNIFYFHSIDTNIMINSTRIELNFIRSYLNEKSPYVMAISIVLLLNATISYLLMLFRGKLSQDWLLYGQQQQQQQQSIREKRFHFWTPYIIWNCLALIISLALEYSQKFLQIQIWLIGSTTIVHLLFFPSMLLIYFAAKTIRSSSSSSSSSLPLSTNSNNNGNSNRQESIMQRFRPLRWPWIFLFISLFLLATTITYLIFWIYGYWYDESDFGYFNRIRHYDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRW2</accession>
    <name>A0A922HRW2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CCDC94</name>
        <name evidence="12" type="ORF">DERF_011266</name>
        <name evidence="11" type="ORF">HUG17_7124</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRW2"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="282"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="108"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7636918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9506541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="321" mass="37686" checksum="187872340961BD09" modified="2023-02-22" version="1">MSERKVLNKYYPPDFDPSKIPRLRLPKNRQYTVRIMAPCNMRCNTCGDYIARGKKFNARKETVDNEEYLGLKVFRFYFKCPRCMQEITFKTDPKSYDYTVEHGATPNFKALKLAEQQAIEEQKEKEEEERLNPMKMLENRTKASRREMENLEALEDIKEMNQREVAINYDELLRKKKEDLEQELKRQEAEDEMFIKLIFHHKETDCTDEHGESEEVIEEFDETEPNSSSCNEISSIQNEQQRPICTDILATATTSHEDQIKSINNKNKRKLIQKMIVVKKKVKVDDDDDDDDQLQSKNNTSNSTKSNVITSLCDYSGSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HT67</accession>
    <name>A0A922HT67_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HT67"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="75" mass="8842" checksum="9072C3EEC89C5759" modified="2023-02-22" version="1">MIEDLLICEITATMCDENNVCCSSNELFRSPRIYVEFCSELNIQLVVNSCKYLGIEYTRDRLLKTIFLNQYDYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTF3</accession>
    <name>A0A922HTF3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTF3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="129" mass="15519" checksum="3648AA4772054290" modified="2023-02-22" version="1">MIETSISRRRVNTHTVIPRHRHNKSNKNVIHYNQWYQSIFMLIFHRCHTAHNAGNRIQVLHYSFFCSDRLVFDQSTHTCRRRADAIPCETSPLFFDLNDRIGSDGPFLTHGDIDREKAVRPEYRRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTG4</accession>
    <name>A0A922HTG4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_010683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTG4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000005">
        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="174"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="267"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9505917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="283" mass="32062" checksum="B6EF0FF3EF089CF8" modified="2023-02-22" version="1">MCKRHVYQSPIMKVYYLDHNHYITKTMECFWRFAITRRLSSLSSSSSSSSINKNHMDMIRARNTPPTTTTTTTTTSMIATTINACSKRHVTGICSGIIFDTQIFSGAILSLSSISRSLFDQYHQACRQHNFLSNRNHHHLQIRLFSDQKKSTTTKMSDEQSKAQSATDDGQETIFGKMLNGKIPAKFIYEDDMCVAFDDINPVAPVHFLVIPRKPITQLSKTTDDDEKILGHMMSVVRKVAEQKGLATNGYRLVMNNGRHGCQSVYHIHFHVIGGRQLGWPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTL0</accession>
    <name>A0A922HTL0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_012928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09077">
        <property type="entry name" value="R1-I-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052560">
        <property type="entry name" value="RdDP_mobile_element"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36688:SF2">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1305"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9502139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2191" mass="248163" checksum="14C451C5EB77EC1D" modified="2023-02-22" version="1">MGSGKKSSGRRVVKNNQQINIGSEDDQSTSSPVMNVDDEVTIEDTDQPISHTETNPSTSASLINHSSPNQLFIPNASVQNQTMTSNYSSVAALYQQPNQYSTGTASTAHQLTTTTGFQIPQQYVPPLYQHSGYQQQYPPLTIQTQLPSGFNFQNQPTSSNQIFYASSSSQPIPAATSITTPITTTFSRSKPTSRSNTPSRNSTPRGSLNNLGDLDDHKFMKDTLKMVTSLAGNITTQKKEQVIEVIHRAICLLTENDDLKEQLVSANKRKRLTNDNDPRDVLMNDDSEFVTKTELKSCLDDIKSSINNLANAINQQKSNNNNNVQNKPTSFADMIKKTNKSAATTKHQTVVFIPDNDDTAMTRQTLTKFIQPAKEGIAMTDARSLSKGKMIIDFRDQASKSKFDLLAKATNKIVTEPPRKLMPTILLKGVRRDIDKSTIPAMFESFNYPIALFADTNKLDVTKLIEVVFERKNFRSERLINYGISIDPRIRDIIINEMNGKIILDYSLVHVEDASPLRQCFRCFGFNHKAAVCQLELNKQICFHCALFHKFDDCPNKMRPPRCVNCRKSGFNDPCNHNSISKSCPIYARMLQRIADKVQYSLDSPSALSQFLNFCDKNKIDIALVSEPPIRNNIPNIDKKYRPIYATNSFTSITNSSNRSDASRSLPISQTPSLSYIPAVSQIQSAIHVSSSNQSSSTHHQPSCVNHVSGVHHVSYVQPDPCAPPVFTNQVPSDPQVCQQSSHQVPAVHMSCVQPDPCAPPVFINQVPSDPQVCQQSSHQVPTVHMSYVQPDPCAPPALTNQVPSDPLVCQPNVHHVPTVNVSCAQPNSCAPPVSVNQVPSIQPSPLVDHSSNVLPSATQHVSSNQPINNNPPTSNVCLPVRSCILIFNPMITPIIISSLSYTDFVVIEINGFIIASVYSQPGVAIEPTIRNLDNLVQFAHNKRLLVAGDFNAKSTFWGPINDERGEELLASIIQNDLCILNDGIKPTFDTTRGNRRLTSFIDLTLVSQNLNDKVKNWTVRDDIHNSDHRPIITVINNIRLTSSDSGTTVRWSTANIDWSAWSSEIGNGLDGHSITCDDIDSIDDRQQLDLVIAIFTNIVQQTCDKFCVKYINKRTRCDTWHKDNELRQIVIKQRQVYRKIRQCYNQLALQRYKNEYQQLRQQYRDHLQNLKFKAFDKHINGEGQANCFQKVSRLIKNSGHVIVKTIDGTNSPAESTIKLVDALFPTDDIDNDTDEQKSLRRYIDLWLRKNHTVISPPPISMHELHRAITKFKDGTAPGYDGISPKILKNLWISFPEILLAIYNACLRLNYMPYVWKTAIVRIIPKPGKDDYSKTNAYRPIGLLSTMGKAFERIIANRISGHLLNNGHLSTSQFGFVAGRSTDHAVYNLNRDIESAMASNNHVALISLDIRGAFDHAWHPFIISQLIDYRTPIYLIKTMANYQMDRRICGSHGGVSFCKETNRGVVQGSMLGPLNWNIVVNNLLMKNLGPDIKMQAYADDIAIIVSSKCQTYLPIKINNVLKLAYEWGAKCKLTFSEAKTQVMFVTRRINRPIYSPVIMNGIEIKPVEQMKILGVIFDHRLDYRPHIHYAVSKAVKVYRAVNSIARKTYGLGPRVLQLIHHCIIEPIITYGAVVTRRAVQYQHVIKELRQMLKPMAQKATMAYRTAPIIATSAIADFPLIDLLINYRATVVNARVTKLYSHLDSDIPVDIEEVRETSADVRINFILREPAVFPPIRIFMKSILTNHGIGTAFMAFNQNNRIITKSYRLPVYCTLQQADFFCISMAIEWSSVNLGQQATYIMTNNIGTVQHLKRTDHRKTQRLANIITTMANNNITIMWHKVDRENRWYRNLKQLARRTGKHRNRNYDYDRIQMNVIKKLERRNMLADWNNKYTNDRFGTTIKTICPQLGDARQFSRYRAAVVNARVTGMYTLYDTSLNVDINDNIINDSTSKLTTIIREPSVQPPSRIFIKSIKTNHGIGSAFMADLFTMINATCWLKNQNNNQTTYIITNNISTVQHVNRQDRKNRQRLANELIDNIENNIVIVWNKIDKGENWYRKLKKYARSTANNQQRQVDYQRVPMSFIKKFEQNRMLISWNDIYRRDRFGSNIRMICPNVQDALCRQVQQVNRPISNNKITTIHEKILQSNNMIDQSSTPLPANNENEIINMEQLISQIAYQNNPTNDEIKEQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTP8</accession>
    <name>A0A922HTP8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTP8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="11389" checksum="8ADB703A7AF310DA" modified="2023-02-22" version="1">MSDNEDQRIDDNNNENQQQFVEIAENGITSFTEELVFIIELFVQILLIYCLCYLCTMKKFLMDQILVQPNLLRQPPTRWSAIIVHFRSSLLFFDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTZ1</accession>
    <name>A0A922HTZ1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009425</name>
        <name evidence="2" type="ORF">HUG17_7338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTZ1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="628"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="852"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7637132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9510935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="874" mass="104204" checksum="5B64A594B3D9BF11" modified="2023-02-22" version="1">MSGFLWLTKQPWMDVLYRWFAPYQLRYTNAFTQTTLNQINHHRRYRFEICRRQLPTISLMVLMVMIIIFLDHDEQLTIIWAIKQSNVFNIWFGHQFTRVIVCCYLIFLSYGSIMIMHRFLPFCHNKWNNMVLKDLLEYHNRKLPACRLRLLRGCDSNTLKHIDWTLFGLEIIFTLAPIIYALVALIASAIFVYQLYHNPPATLLVAIMELYVFGIGIIVIFIIISGALWLFIDAELRTIYFQDCFIQLNSLMNASVRDIHNVRRRKCKYLDHSGEWERRLMHFMYRHNFLCWFLQRMNPWWKRRNLICVIITIPNNAMMVNLLLFQTFEPRRFLVLFAFTVLQLVLAAIAEGIIPAINYYAIGARQSMYAYLALLPQHSASFSVRSNLKALSYLERITSDRMTIGVQIGIEQFVITYASYWQSKTNMSGFYWLTNQPWVDIFYRWLSPYQLRFATDFTQTTLVQINYRRRFRFEICRRLFPLISMMLFMVMVFLFIDHDHIVIIKALKESNVFNIWFGQKFTRIVILCYMLYLMYGLVIIVHRFLPRYQSKWVNSLIKELLEYHNGIKPITYTTLLRQCDQSTLKHIDWTVFGIEIIYKAIPLAHGLVAFLVAILFVMQLYYDPPRTMLIAIIESYIFINGITVARIIVTASCWLLFISELRCVYLQDRFMHLNSLMKNLHKASLEMTCNRYNGRNIISNQRIHSYSIHRLVYFLHNHNSLCWFLNKMNGHWSECNMLCMVFNIPNNAMMTNLLLFQKFDARRFLVLFLFTVIQFVMATIAIGIIPPIHYYAIGCRQHLFFCLCRFSQYTRPILSVRLQLKSFVYVERVTSPRMEIGIEIAPRQPVITYASYWQFFVLYIGYFARIVKLFRQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUT4</accession>
    <name>A0A922HUT4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Intraflagellar transport protein 81</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">IFT81</name>
        <name evidence="9" type="ORF">DERF_010725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IFT81 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUT4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.70">
        <property type="entry name" value="Intraflagellar transport protein 81, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029600">
        <property type="entry name" value="IFT81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041146">
        <property type="entry name" value="IFT81_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043016">
        <property type="entry name" value="IFT81_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15614">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15614:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 81 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18383">
        <property type="entry name" value="IFT81_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT81 calponin homology" evidence="8">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="168"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="319"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="490"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9505963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="683" mass="81174" checksum="22250A0133D69042" modified="2023-02-22" version="1">MDQIKFVIDELNQPPFNQNLNLISYDNLREEQRLDLLIQIFNVIDPKLNLPFIRVGNIEDIVATILDTLRIFKYSPPSSHSNPVEFRKNLIMADKDLLTNIIEWLLRRLPLLKKRAYLAHFLVKIELSPDVEGDQDVMILYQQYLNLIDEFKRIHSSHEMQKKSIDSIIELQKDIKTMELEKDQIKNKLDIVKRRVNLDMIETSNSVHNIKFDSVRAFVMARHENEKLQRQLREQQERIVMAKKHLEQQQTELNELNVQDWQESIQSPEVMLYRYKDEIDIKSKLVKDVLPNELTDLRLLVRDMEKTQQHADSDVTEQLQRTVTQVQVLTHEINELVEKKLLDKQSEEDRLSHYRQNAQVVAKKKEDAIKQCEQLEHQLATQQAELEDLRAKFSVDGESTLRGDALKLYIEKISRRETEMNEMKEELSRISGDIDELQSKLRSLRQQEKETLEEIQESEETIGLEGYFQMKESTLNALDDDEDNNIDDDNDKEQLNYEEINRQVDNFQDRLEQIKSSLVDVTKEVRILKEELNEAESEFDMKKRLYDSAAAGLEAELSRRESEFERLIGERDDLIAEQFEIQTRLLALQIEQKELLGMDKSNRLIEQLKMEIDSEQKLQENLRRHEIEWKEKEQYYKKQMEMWRDLRVIFETKSRLLAQKLEQKNQQSNAMIMIKDHLVLNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUX9</accession>
    <name>A0A922HUX9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUX9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="256" mass="30228" checksum="39B6E623FCEC5ECD" modified="2023-02-22" version="1">MSPLPGHPSYMLELQCPLYGDIRVQRVKFDGRKSNWLSFRDLFVTRYLANSQLSETEKFQLLRQAMPVYLHSFFNVNPTLKNIEWILSNLDDRYVSPDDSINEIFRDFKKIKPAFVNNDLRRLADELMVWFRRASDAEADSSRVEQEFLDNFFSLLPNATAMLTKIFGHNYSLRRSSPKAKRFDENQWSLPPKSGENIQTENLLYWPGFIDVRPIVLNSDDIQWSSPSPLASSQFIQRRKDTCHSPQQHYYDYDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV07</accession>
    <name>A0A922HV07_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_011461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV07"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="280"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9506744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="379" mass="44805" checksum="5FBA9ECFE759A84B" modified="2023-02-22" version="1">MTNITDFADCDFLLPIDNDRIYLKDYRSYWTLEPVMSSMCWRSNGEQPPFFSISSISPNFFDRRQSQIITDYDGCNSEMLNADKYLLYQNPEPMISMNDGDVLNIENVKKEYLFDSCDDANHSNYKWELDDFEEKFSTQTLNSVFYSNFDDDGNVHNLITDDQQLFIATIPDHNNGCQMAVHQQQNVQSPVMIKRESSPMFEAERELETISPQPLQNDYDDDHEMVKLSEIADEHIKIKPRKAHGRKSKSMTVLSNNIIDDQQNPESLKPLLAKQKSLLFPLKLWNLTNSSLFKAINWSKNGREIRINIKKLTPFLKQITRSNKFESFLRQLHLYGFRKMDNFNLKKRKFDRNIVRYFRRGFNRFVRNADEIDKIFLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV86</accession>
    <name>A0A922HV86_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Sodium-potassium-chloride cotransporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DERF_011615</name>
        <name evidence="23" type="ORF">HUG17_10078</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">JKM2019</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>K(+)(out) + 2 chloride(out) + Na(+)(out) = K(+)(in) + 2 chloride(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72395"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:72396"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV86"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000022">
        <property type="entry name" value="Bumetanide-sensitive na-k-cl cotransport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013612">
        <property type="entry name" value="AA_permease_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002443">
        <property type="entry name" value="SLC12A1/SLC12A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00930">
        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF103">
        <property type="entry name" value="SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08403">
        <property type="entry name" value="AA_permease_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01207">
        <property type="entry name" value="NAKCLTRNSPRT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0868">Chloride</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="614"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease N-terminal" evidence="22">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="20">
        <location>
            <begin position="192"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="21">
        <location>
            <begin position="700"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="21">
        <location>
            <begin position="853"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH7643387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAH9506907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1054" mass="117350" checksum="39A0A683C7968118" modified="2023-02-22" version="1">MSTKDQNVGTTNGEESRPLIVGGGQNPMALKSNLAKPRVEDNNGQPISSATSPPKQIAFRTASHTSPAAAAAAAANAENNRFQVDKVDDNDDNSEDSEDSYGEGLYGTSGAGYATKNLKSFRHYTREALPRADHYRNVESVHGFMARPTLDELHGTQATVSFDSNTGKIVIQKAAEEESKEKQAVKFGWIKGVLVRCLLNIWGVMLFLRLSWVAAQAGIVQGTIILMLASVVTLIATMSMSAICTNGEVKGGGTYYMISRSLGPEFGGSIGIIFSLANAVAVAMYTVGFAETVRDHIGQYGKIIFDGGLNDIRLISSVTTIILLGIVYIGTEWEAQTQVFLLFILLTAMSDFLIGSVLPPTDTQIARGYIGWSTSLIWENMFPAYRNETFFTVFSVYFPAATGILAGANISGDLKDPSYSIPLGTFLAIIITTISYVGFHFMVAANVVRDANGVVELVHHPGVKDVVQAIRNCSLAPDEICRYGSMNNFQIIELMSWFGPIIYAGIYAATLSSALASMVSAPKVFQALCNDKLFPGIAYFGKGFGRNNEPRRAYILTFFIGFGCCLMGELNAIAPIISNFFLAAYILINFSCFHASWSKSPGFRPSFKYYNKWIALFGSFLCLIVMFMTGWIAALLTFVIVLALHVWVQKRATDVNWGSSTQAQTHRSAVTSVYKLTMLPDHVKTYRPQILLLSGNPPTRSDFVDLAHLITKNAGLLICGHIVTTPISVRAQNALLHDGNLYLINRNMKAFFTLIQDASFSQGVRALIQSTGIGKLRPNIVMLGFKRDWIDCDRKEVVEYFKAIHAIFDYHFSIVIVHVPNRKQVTNGDVKPAVPAITDKNKDMAVVQMKDDAIPLDSFFLAKQKKGYIDVWWLYDDGGLTLLLPYIIRNQSQWKDCKLRVFALVNKKSELDAEQRNMAQLLSKFRIDYSDVILITDLLKPPEEYSKREFRRMIEKYIVEDSEERHDAGHKDGMTLTEADLVRFRDKTYRHIRLREILLNYSKDSRLIVITLPMPRKNSCPTVLYMAWLETLTKNMPPMMLMRGNQTDVLTFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVP0</accession>
    <name>A0A922HVP0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_011566</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVP0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18913">
        <property type="entry name" value="bHLH-O_hairy_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000009">
        <property type="entry name" value="Transcription factor HES-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9506855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="351" mass="39166" checksum="7F03FBD87D553ACB" modified="2023-02-22" version="1">MTANHGTVESSTNELSINRNNKPMTKASEHRRITKPIMEKKRRARINNSLNELKALILDALNKDPSRHSKLEKADILEMTVRHLQKLQRQQIAATIVNDTTLLNKYRAGYSECANEVGRYMNNIDSGIVGGGGVVDHQSLRQRILGHLNHCVNSLNQMVAATNNTNNVHNTKMVAFPGMIPSNVNNLHVQIPVMFGGHPQQQQFGGTDINNNNRTTFMDEIYVKHSGISSTTTSSSATTPPPSSASSSSSHFAFNLHSPTLSTTSTTKPISLTTTNDLFYRKNFHHQRQHHQHHHQQSLSPGSISYTSEQMMMSPIGSDYCLDDHQLDMAVDCTISKSSQSSNDENVWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVZ8</accession>
    <name>A0A922HVZ8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha/beta-hydrolase lipase region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lipl-2_5</name>
        <name evidence="9" type="ORF">DERF_009075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVZ8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000057">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025483">
        <property type="entry name" value="Lipase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000862">
        <property type="entry name" value="Steryl_ester_lip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037249577" evidence="7">
        <location>
            <begin position="23"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9510551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="353" mass="40672" checksum="F563BD6E2DCA50F9" modified="2023-02-22" version="1">MIAWNYSIIAILLTILLAITDGQSMHEDDPDQHRTLVELIESRGFQVEEHSIETNDGYILLAHRIVWPKNNTINSQDLKPMLLQHGLFGASSDFCINSPFLRTKRSLYGDTMSFALMMTKRYDVWLGNSRGNRYSRRHRTRSPANRDFWNFSWDQMATEDLPATSEYIRNATGRKTLAYVGYSQGTAIIFALLSLRPEYADIVQPFIALAPITFVKNIQSPMRYFSPMKPLLRLIGGVFLPSNTLIDNLVDRFCVYPDIRPLCANLIFLFGGFDKKNLNETRIGVYLHFTPSTTSTWDIAHGLKPSNRKKIGRNEKTQKKISNHNLLMRTLKRRRMMRKKGKRNLKNLAATHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWT2</accession>
    <name>A0A922HWT2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009369</name>
        <name evidence="2" type="ORF">HUG17_7298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWT2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7637092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9510868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="221" mass="24476" checksum="24DD3330E766432F" modified="2023-02-22" version="1">MDDKSKTNKAIAKNSLKKGLAKTSEKSSLVGKTLISKQKLSRSLNSKQLDPLGLYGKKSQFINVKLAKDKSIPTPIDLSLSTTSISSSNVDSSFSPVKFNVPTSNTLSESSTSIKSSNLFKKGEQSRRNSLSIIVEKQSISRDDQPKTIDKSNISPVIITAAPQQKPANKKESRPGSKNFYIELFKKMMGEYFYSSDFISFVGLNFLTIAIVLVIKWIRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HY64</accession>
    <name>A0A922HY64_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_010066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HY64"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20811">
        <property type="entry name" value="C1_Raf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003116">
        <property type="entry name" value="RBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02196">
        <property type="entry name" value="RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="398"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9511618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="516" mass="57520" checksum="EE48124F601E6323" modified="2023-02-22" version="1">MVQFVTMDNTNNNLTTTNSQNNANANANNNNNLMMMMNSKSSSPLSSPPPPPPAPPLSSSSSSLLNHGHLKQTTEASTTTNETMTTSSSSSTMQTSQTILQQQQQQPQDTNSLLLPNKMLLNVYMPNQQRTIVEINHHHRNQNGDDGFSGINDGHGQQQNKQQTIRDVLMRAMKKRRLTTDVCYVCYTDNGQPIDWDTEVSRLQSRNIEVRIIAHETRREFFSLANCDLCHKLIFTGLRCQACGIKYHLRCGQLISPICLARQYNIIHKMGSHPHHHHHHHHHHHHKNHQSSIIDMNGNNNNGNGVGNNNVSGGNNNNTISGGGGGKQDIKRTNSEPDRINIINTTDQTIPRILRSISTPNLNDDFVFGAGNGGGGKSTAVDFVEFDLHDYRSMLPQTTTTTTANNNNNNNNNVDYENSDFMDCIDDDDNVDCMDDDDDDDASSTSVSSPSIHHNHHQQFNEILTTTTSPIIDHNENIVSFNNNNNNNNSDSSSNNNNNNNNNNNQPSTYYMLTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYF8</accession>
    <name>A0A922HYF8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier 2 (Facilitated glucose transporter) member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC2A8_4</name>
        <name evidence="11" type="ORF">DERF_010455</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYF8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000218">
        <property type="entry name" value="facilitated trehalose transporter Tret1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF1">
        <property type="entry name" value="GH07001P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="66"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9512043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="526" mass="60004" checksum="2B00ADC8F35A9F02" modified="2023-02-22" version="1">MSPNLHKQQIEISQHYPPYHNHIVNIIDLHDEIQNIDQILPPNIELNQLETRDHSRYQSSWLVYGATLSAHMASIIMGSTFGWNAPAMEEMNENFIDEKQWHSPLVPTDQEKRLISSILTIGAMLGGLLCGLFIDRFGRRKTLMSLGLPYGIGWLCIAFARSTFVILVGRVINGLGIGIAIATVPTYLAEIATPNNRGYIGMSFNFFVVFGIVYMDIINILNFHWNQLALWALLPTALLVITMYFMPESPTWCMNCIETSNDALRLAEQNLRRLRTKESDIHGELRDLCEFKNQIQKAKKNRIKLSFQSIQRSDIYKPMLIAIFALFFQQFSGINGVQFYMNDIFVKSGSNLNAKLSTLISNGFMLMATIVGALVIDRFGRRILLMFSALGMALSIGVLGFYYYQHPELAHDYEGSIEQTNSWLPIICVSIFVSSFSLGVGPIAWVIITEITPPQTVWLISSISSIFAWIWTFIIVNETQSFFILFKEYGTYWIFSSISFICIIFAYCLPETKGKTMEEIRKIFHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZF0</accession>
    <name>A0A922HZF0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZF0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12925" checksum="CCAE6C87DC1D5AD7" modified="2023-02-22" version="1">MQLTSSRATSLIQIQTNMSSKQRLHSQCESPSKHVSLFKNPSLLSSYFAFITTNSNSLSSSDAKLATKSCHLHYENQNLKWRHQQESLPSLIIFIIAIIMMFLLPTFGESYTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZR0</accession>
    <name>A0A922HZR0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">EIF4A3</name>
        <name evidence="17" type="ORF">DERF_009718</name>
        <name evidence="16" type="ORF">HUG17_7562</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZR0"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="61"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="242"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7637356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9511246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="403" mass="46140" checksum="024B4733B5C2AD9B" modified="2023-02-22" version="1">MSTTKKANPTMPDDLSNVEFETSEDIEVISSFDSMNLNEDLLRGIYAYGFEKPSAIQQRAIRPIIKGRDVIAQAQSGTGKTATFSIGVLQSIDIQTRETQALILSPTRELALQIQKVILALGEFMNVQCHACIGGRTLGEDIRKLDYGQHVVAGTPGRVFDMIRRRNLRTRSIKLLVLDEADEMLNKGFKEQIYDVYRFLPPYTQVVLLSATLPHEILEITSKFMTDPIRILVKRDELTLEGIKQFFVAVEHEEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMKEANFTVSSMHGDMPQKERDSIMKEFRQGKSRVLITTDVWARGIDVQQVSLVINYDLPNNRELYIHRIGRSGRFGRKGVAINFVKSDDIRILRDIEQYYSTQIDEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I063</accession>
    <name>A0A922I063_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I063"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="243" mass="28111" checksum="C975042F891E8217" modified="2023-02-22" version="1">MRFLSLYSYSLKKSPKDLRLAIVACRLSLILAIIAFILFLLTVFVLFTNKSNHNYAFSSLLSDQDDGNSLEFAKQSDNFTNLNTPSVHFRTVDFSGEAIKLDYKNNSSIIFLLIGFILYICVTISSIYAYVSYRNYRQSRMVNYEMINRSFDQMYSEQIAKLKIKDPIIVSSNPKSLTEAITVIKVVESRKPTTSMPCTAVLNNNPEHRNKFKFWSRNKHQRQLQNQRRFSYGKAAISKEMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0D2</accession>
    <name>A0A922I0D2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0D2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9518049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="35" mass="4015" checksum="2408C0CD68932953" modified="2023-02-22" version="1">MSNKSVESQYGSCTIDNNNENPTGSKWNTQLKYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0P0</accession>
    <name>A0A922I0P0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0P0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9518214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="502" mass="57360" checksum="05A992B413ADF5E4" modified="2023-02-22" version="1">MLKASNQSTIDPIIISRDYKDGDANISTLIHQEPPSLPKARQNNNISSSNVRMMMSSTSSSTPNIMTNNVSNNNSNNNNKSNIGRTGSTANMATTEINNNNASLQPSNVIINTNLQRQQQIQNEELSVLTSYYACARYYLFMVYILVLITLIINTFIHFIFYGSNMSIGSMFLDVHHRQELINGQYYSLDNNNYAPNNYLSASTFNIGRDRNIVQHGGPYGTINHRPLSKHLGSNEQIYHCDRSSFLSLLDEFYHQYPVPKPQPPTYDSSDRMNLDGRNQLDGDDDTKSYPKIFANFDNYARTKDRQDLNEEDDIFYSSSSRSNDEESLQASRQRLATISVDKRFNNLNHQRTGNENRMLIIEVIALTLLFVTVLNQVLGLIGVIRKNLTLLIFVTIVNFVLFCILAFISNIGLILLLLLATSAGYLFIFQLKIGLRNRIKERLRFKEDISTEVQDAIMQMRNRMSPCIHVSMEQYEAMTQQMLNRYSSPIVYCPHYNESLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I123</accession>
    <name>A0A922I123_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I123"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="91" mass="11180" checksum="814C290E6EDDC4AB" modified="2023-02-22" version="1">MDIRTYRDGSDVDDYTKENNEQKKTRNQMTDICEIKLKLDSVNHVKKQNRHVERDGRNFRFLFLFFLFSNKNQIKQEKKKKYPDDNMLILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1J6</accession>
    <name>A0A922I1J6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1J6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7527" checksum="6DF04D5E4D8EA456" modified="2023-02-22" version="1">MPSRYCMVYGYNNHITNYSHWTNYMTIWEYIQDDGFNFLFTTTKKNSIILSQQFNNNNKNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1T2</accession>
    <name>A0A922I1T2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bromodomain adjacent to zinc finger domain protein 1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BAZ1A</name>
        <name evidence="12" type="ORF">DERF_008888</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031445">
        <property type="term" value="P:regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047171">
        <property type="entry name" value="BAZ1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46510:SF1">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WAC" evidence="11">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="10">
        <location>
            <begin position="421"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="1085"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="652"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1240"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1247"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1265"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9518298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1305" mass="152000" checksum="0B884F4971346A4C" modified="2023-02-22" version="1">MPLLGKEEFCLKSLPDNLSPDEQVFYCQITGEAFLSYDEYFERQFLYSSLLWTCSLTGRTGLTYSEALKSEQESQALVSSIPIVLQKVMLHLMTYMNNFSTNVTLSILIEYTNLRYFIGEHVQISPKNKNKRINGIIRDVIPPENYENTSSIAYGIDPLAYNYRVECIDQHDENECIVIPAARISRSKFLLTREKIRLFLKQHLAPKNGRYQALSIKAESLQKFGVDQSSWEDMFKGPTPNFSDDTLIVKALSRQRYSEEFNSHNHDSLNVNDENRENENLIQVLKKKSNLLSSQKQKLKRREAKQSNSSNIKESNDGGKRKYRKNLKKDNKLKRQNLKNKSGKSSRKKRTTPDAADSNETQDSKSSKQKDNEKDLKNRERECRKQYEEDLKNWAEKRDDFLCDDLLPLPSVTPIECDISPELIGDALVIIDFLNVFHEFLAFEPNTFPSHLTFDYFIKILQDNNVNTRTGIADLIMAILRTIFQSNRKDSHDGNDDLKIQENNNEDFDIFNADNDEESTASQVNCFANHFVTTYFSTLEQLARLQMDSFTVTEILRIYILKTRNFDGKRTTKICPDDMALVMHLATQTIFELNHSDRIKILKILLNDVVVQVADIRQKIESSMDDMVKLKIQMRHLNASYTRWLRENPIRQRMRKKKSSSNSNNDDQQQQQTELETELTKEEKEQYKKDKAEKEKKMKDDIAELKAKIRRLSAFCRSRPLGIDRRYRKYWIFDSIPGLFVEHSVHDEHDPNTCFDNPVPVAKPILNDYLANAKRRKKKTTAIPIVEAEMENVVEQNIDRCSGNPTTCKVHGSMFMTTAPLWSFYTKEQFDTLMDSLNSRGFRESELKNALAIEKQSILNDHLAEFDPFIFNRNYIPSPVIEIVEHEMNDDVNPVRKSERLQISDRATVTNKRRSTRSEFRLEYSDQTPVEVFDVNFQNQLAIFEDNIFNGCFCSFSITDRDEWYHGLNRTYCQDKINSLQMLTEKLASLARSIRPFCLMPPLSVYPESTMSSPSEKENIDNNQTMKFRVPMLSEKWLDVLKVPDSSELTEFESSYGITNHSQLFLNLYIFERSLNWEMSALKTANKCGICRRKANDEMILCDFCNRGYHIYCLTPPISSVNEIEGDWYCPKCLPRSPSDHESSNNKKAAQTIKIEVEAIDQQQTEQLSPPISNSKINQQPVNESLLERCKSCRKHIFDSFSEVSCKTCGECFHLRCVNLVRVPRSWNCAVCNEKEHCDEQYNNPHNDNDNSELRRSQRKRKPNHYHEFEPNDDQYHHQSTTNNHLKSRRCSDGQNSEYHRIIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3F1</accession>
    <name>A0A922I3F1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ankyrin repeat domain-containing protein 13D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ANKRD13D</name>
        <name evidence="12" type="ORF">DERF_007420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3F1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF31">
        <property type="entry name" value="LD31969P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="6" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="8" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="11">
        <location>
            <begin position="161"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="703"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9516695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="765" mass="87993" checksum="855C41CF423677B8" modified="2023-02-22" version="1">MLTEDDIQQRYPLHTFVWKNSHSQLKDYLSLHSKDVNLEQKDIRSRTPLMLAAALDHKECVRILLDHNALVNVTDHTGFNVLHEAVTTADPKLIRDVYLRKELQRINSIRVDGIPRLLSKICDTTDFYLEMKWEFTSWIPLISQLCPSDTYRIYKRGSKVRVDSTLIGIDEVTNEATIDWQRGNTSLILSGSENGCTFIEIDHNKRSVHKRAMEIIRPDEVHDLLGITEDQIADRLTQPIKTMYIDSEKVNFERAKSGFIGFRTDRVDQFNGYECKVYLAQNVEFITKTRIEHLTQEDKMRYKKMKDSSSLASFRSIVGIHEQNIPNPFENDEVYNSNPELRRNPYRLSLLDYFNLTPDDPRDIGSPRETNIKKQYFKANIWMSDDFPLSLKEQILPIVDMVATYSSHFAKLRDFITGKLPTGFPVKIEIPLFHLLNAKITFGNVFAQDSPVDGVSMSCFPDKSTINPGKEDFISPSSSSSNNHRNGKCTVDEKCFEPPEDYQILGNNSIFSMMSLDNHSENSAIHDDEDDDEYIKYILNQYNAKKTSSSTNDKCHIMDANKANQDQQKKLKTEPELSIMEALSYDSEKDLQKAIQLSLMEYNQQKDREAHVQSLALQSPSVNQIHANGSIVKSKKATGTKSIGNSSQIKCKEDSVLMIDDKIMKDVEDRCSITSSLSSYQSCDNNNENNDSNENIVPSAANNFINNGTHRRDKNESEVENVEEDEEKQLIQLTMEQSKRDHDEYERRRQMEEDEIIYKSNSNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3N4</accession>
    <name>A0A922I3N4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="6">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ5</name>
        <name evidence="8" type="ORF">DERF_007534</name>
        <name evidence="7" type="ORF">HUG17_1911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with PYURF; the interaction is direct, stabilizes COQ5 protein and associates PYURF with COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="6"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3N4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000064">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001244">
        <property type="entry name" value="PRK00216.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7646373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9516815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="307" mass="35485" checksum="EC043F4392403DD0" modified="2023-02-22" version="1">MIARCFQNKTYCLSRKIPLLNCLTKRAKHQSISKHDQVSIDCSQTNKDGDNDATNYFGFKPVSDKEKFEKVYNVFHNVAGKYDLMNDVMSFGIHRYWRNELIKKLDPIPGTRLLDVAGGTGDVAFEFLRYTNENNDNESSVIVCDVNENMLKIGQKRAQKFGFHHDRCQWVIGDAMNLPFDTESFDAYTISFGIRNVVDVNRAVQEAFRVLKPGGIFLCLEFSSQVNNPILKSVYDWYSFQIIPVMGEILLNDWHSYQYLVESIRKFPDQQTFKSMIETNGFTLVDYENYLSGVTSIHYGFKPLFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3U5</accession>
    <name>A0A922I3U5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">NADH:ubiquinone oxidoreductase, NDUFS5-15kDa</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Nadh:ubiquinone oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">Ndufs5</name>
        <name evidence="15" type="ORF">DERF_007619</name>
        <name evidence="14" type="ORF">HUG17_1984</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3U5"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21268">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21268:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10200">
        <property type="entry name" value="Ndufs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7646446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9516905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="116" mass="13855" checksum="51D61EA46815D2CD" modified="2023-02-22" version="1">MPYDPHLRFIDRVVRTNADSVDISSKTLQKQQECGDLEQDTLECLEAYGVRRGKKLCNDFLEDYKECMLQTMQRERNFLMKRERLKQVMRGERKPMEVFDPIKPPRDAYQSGPFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5J8</accession>
    <name>A0A922I5J8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Clarin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_005540</name>
        <name evidence="8" type="ORF">HUG17_3478</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the clarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5J8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026748">
        <property type="entry name" value="Clarin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548">
        <property type="entry name" value="CLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548:SF1">
        <property type="entry name" value="LD47387P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25807">
        <property type="entry name" value="Clarin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7639445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9521927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="30216" checksum="EBAB69CC5CD63712" modified="2023-02-22" version="1">MEQRKRIYIFITFFICTSCLALLTLSLATHRWIIARPIRLISLNSSTIFQLNDYDEHTEIELPKKFRGFVYFGLFQGTKVLNYGLGDRTTIIWLKQEMLRNPNLMSFALWLLTILSVSIAMIFGLVAAIFSIINTVMTPIEAITGVQGLYLWNALASLFCTCAAITWLIQYQTRLIKNVMTDDEQQDGWTSLNRTSLSFSYYVVIIALALHLFNIFIIYYGTTMIDNVTQRSNCGRSRRRCSKDRRSNRNDKHPEGLIMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5R1</accession>
    <name>A0A922I5R1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_005390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5R1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026095">
        <property type="entry name" value="Myb/SANT-like_DNA-bd_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22666">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22666:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9521758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="352" mass="41017" checksum="20E53ADCBA786CA1" modified="2023-02-22" version="1">MMDVSDHHHHLHINQHNPDQHQQYSGFIFEDLDAAFLSVPNNNDEDDDDDGCCGTGGGEDKVTLIKDDDDGQTYSIMNGGDLPSSSSSATISVKKDYKWSPNETIYMITSWEKYSKNASGKTSTYNKWIYMNIQQDLQSSGYDRNLEQIRRKISQLKSRYFKEIRQSPNNVENSTTNWEYFKQLDRILHHQYHGDNKNINDQQSSSSSSYLMNNSENYPIESPKPPTESNKRIRTINYDDNNHNDDESNDDSSSVSVGQNSITAGDSTTTTTTANSFEDRIMKMMKTQYRNQQQQWKRISQQIEQNRQSIDLLQQTINRLQEQLQNQQNGQWYNNGMSMQKNWNYDYNNQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5R7</accession>
    <name>A0A922I5R7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SERine Proteinase INhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SERPINB3_1</name>
        <name evidence="8" type="ORF">DERF_006182</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5R7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037196847" evidence="6">
        <location>
            <begin position="21"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="7">
        <location>
            <begin position="64"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9522616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="411" mass="46877" checksum="126EF5A80DDCF35D" modified="2023-02-22" version="1">MKKIILSIIFCSSLWSLINCQNVMLPKQPEKPIVPSSFVHASNEFGINVLEQLNPSPPEDANEEARSQYPEPKNVLISPFGLVSSMAMMYEGANGQTADQFAKVMKFDQMDKSTIPKAVHDGYDSIKSLTGLTYRMANALIGQDGIGFTDAYSKMIQDNFQAQSFESNVDLNDLNKIFADNMIERMIKAKPSDISMMLVDGTYFHGKWMYPFYEDESHIDTFFGRNDVTYNNVTFMRKFGRFGFTYLSDVEADMIEFPFEGDQIAFYGILPRDPNDDLSDIRSSLNVSYIEKMINKLSYKMDSTVELPRLNVDHEEEQLSEILMKMGITDAFGNDAKFGSISTQPAHLTRVMHRSRMIIDEHDGKRPANNDDDDSATGVAPLFYNFNHPFYYLIRHKQTGQIYMMGEVHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6K3</accession>
    <name>A0A922I6K3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elastin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6K3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036747103" description="Elastin" evidence="1">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9525916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="13360" checksum="9320F2F148A28472" modified="2023-02-22" version="1">MKFIFFASFLVFGIANIIAAEDVAQPNQRLLDPLLPGVGLPGLGAGLPGLGLPGLGVGLPGLGAGLPGLGLPGLGVGLPGLGLPGLGVGLPGLAAGLPGLGLPGLGVGLPGLAAGLPGLGLPGLGLPGVVDPILREEKTESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7B4</accession>
    <name>A0A922I7B4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7B4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34494">
        <property type="entry name" value="PROTEIN CBG25024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34494:SF1">
        <property type="entry name" value="PROTEIN CBG25024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="482" mass="54032" checksum="CC65C2984F59C6E9" modified="2023-02-22" version="1">MPGGDWIPVLSQMKSFVQVITGDMEGACQTQANFSRECPIVSQNWLVVMGEAAIETQRRCLSTMNDFVDGLPIVGHVKGGIHHLIGDHEGGNRAFKAATRTLVVIGAGAVATIFTGSAVPAGIAAGATFDASDSIIHDEPRELLAAVDKVVNKPTGGNVFDAAMGVVGYGMADYSGSKIKTKMPDNNQVVELGSKMAADIHKLNAGMDPNSAMTSGQAFTLGNEIKALNSEINTIRHGTPVYWDERMKHFMLTIMKENNSKGDTQKKCAIARNYKIKKISDDHNRDPRGNLKKTCELIVRLWFLLLRMPNEFNYTGAIIMNNAHEGLLHSFVRHFNQWNRFIDINDILKRLQPIRNRLDQIMRARNGNEALNFVQQLKSDIESLPNDVWVDVKLALFQVQERIYQFIQRNLTYCQYLGEGINNNGQMQVYFDVGNGQVMAIAVSRQLYDPIFPQDRRPVRSIITIFFMTKKEYEKRKTTILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I832</accession>
    <name>A0A922I832_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylamidoglycolate lyase</fullName>
            <ecNumber evidence="1">4.3.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_000778</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds one Zn(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.5" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I832"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004598">
        <property type="term" value="F:peptidylamidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14958">
        <property type="entry name" value="NHL_PAL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000720">
        <property type="entry name" value="PHM/PAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF36">
        <property type="entry name" value="PEPTIDYL-ALPHA-HYDROXYGLYCINE ALPHA-AMIDATING LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00790">
        <property type="entry name" value="PAMONOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="NHL" evidence="11">
        <location>
            <begin position="203"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="11">
        <location>
            <begin position="243"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>C-terminal Xaa-(2S)-2-hydroxyglycine residue</name>
            <dbReference type="ChEBI" id="CHEBI:142768"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>C-terminal Xaa-(2S)-2-hydroxyglycine residue</name>
            <dbReference type="ChEBI" id="CHEBI:142768"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>C-terminal Xaa-(2S)-2-hydroxyglycine residue</name>
            <dbReference type="ChEBI" id="CHEBI:142768"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9526714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="403" mass="45280" checksum="07882928D09995D9" modified="2023-02-22" version="1">MDHRICRLLTLSLTIILLITLNGCYGRFYGRPFVDQDLEDRANSLDDLDDQLSDVQGRTSSSSANDLLYLTSKHAKENREWSLQTEKHHYDQLLSQVSGVAATKDFLYIFHRGNVTWNQNSFNDDNVYQHQDRPVNVDTIVAVDLENADVMFSWGKDRFYLPHGISVDPQGNLWLTDVALHQAFRYKNNNFEQADLVLGERFVPGSDHGHFCKPTDVAVASTGTVYISDGYCNSRIVVFTPNGHYLTEFANNDNLRTPHSLALLENEDLICVADRENDRIMCYSAGLTSSISSDVIRRPPGLLLFELEQSELRKVYAIAHLGDVILALNGGPQSTVGISIDLGTEQIVDVWSPQNGSFYDAHDLSLTPNGQSFFVCQLSSAANNNRSKIVKFDLEDYPVFISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I836</accession>
    <name>A0A922I836_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat protein 39B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TTC39B_1</name>
        <name evidence="2" type="ORF">DERF_001178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I836"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="633" mass="72898" checksum="4408C04C0575076B" modified="2023-02-22" version="1">MNGNCVGGNGGGGGGGGNEKKPQQSNGTNQNNGSTTKTTATKVTGKTFGRFLYESFNRENLDELFRPGQQSIENYNLSLAHQRANCALDMYLGENNVQGGIERFADIIDEGPMESLSWAACFVIRAGLTLDKDDIEKARKCLQHTAKMCQKMMKHSFLDNISKWIVAPNYDKYTDVEIFAESYYAQQLALSIALYAFETNSVFTLIKLAYHLRGLVRKHTELWQVKKRRKMWQDEQSRLYFEAHMRFANGMINVVISHTPPKFLRIMNFLGYKGTETIGLNEMNRVAFDLNAGYWTKMAQLTLIYYWVYGKPHGENVPDDLSLCKKLIEAELQMFPQSMLYGLAKAKIEQINGEFDRAIEILQGLVRAPNLAIAYKAFYFELIWCYAIKLDWNNCILCADKIRESKHSPVCMAFLNAVFRYVKGVDDKNQQLLDQASEEFERLPSLRIRHFGKTMTTEKAALANAALYFKKGKCLVLPVIAMLYSGNYLMFVRDHNQLAKLMDRCEREVKLYEPDIENSHYLDNYLTALFYKCVLLRRQQRYEEARKNLQFILDSRDRIELETSIVPMATLEMGLIEIEQNNHDDDAKKWLDHAEKDFAGYTAENFVHLKVYAAIRMMGYKTDKEMANKEKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8D7</accession>
    <name>A0A922I8D7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_000336</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8D7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000328">
        <property type="entry name" value="CLUMA_CG000981, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="135"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="238"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9526235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="435" mass="49604" checksum="2BB47F82DF601D68" modified="2023-02-22" version="1">MEPSLIASNEWVTLPDWMAIKRKRYTLHQTDEPEFVGMIPNLTVSVGRDAKFPCIVNNLDTYRVGWIRNEDKSILTIQHQVVTRNSRISLTQSEHKIWTLHIKNVQESDRGGYMCQINTMPMKSQIGYLDVTVPPDFINSETSSDVIVRENQNLTLRCKARGHPEPKLTWRREDNKPIEYGNWQLNKESGFEYPNTTEGEVIHIEKVSRLHMGAYLCIAQNGVPPSVSRRIVLQVNFPPMIWVPNQLLGATINDQVTLRCDTEAFPLSLNYWTKEDRSSSSSSSSSSTKGDEPDHGEIMIVNSDRYRIANQEQSYKVHMKLVIKHITIDDFGIYRCHTKNSLGSTQGSIRIYEIHRTPSLSSSSSTSSDSTIRPITISRKKEPSTARILGLNDSSNDPMNEEYYSSRTIGLSSSFGYLVQTLLVFMMITRLLAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAA3</accession>
    <name>A0A922IAA3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pyridoxine-5'-phosphate oxidase</fullName>
            <ecNumber evidence="7">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Pyridoxamine-phosphate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DERF_001141</name>
        <name evidence="18" type="ORF">HUG17_4375</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyridoxamine 5'-phosphate + O2 + H2O = pyridoxal 5'-phosphate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15818"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:15150"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="7"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAA3"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000020">
        <property type="entry name" value="PNPO isoform 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="16">
        <location>
            <begin position="48"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="17">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7641331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9527098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="224" mass="26785" checksum="40EDD75D8A70DCE8" modified="2023-02-22" version="1">MSADLSAMRKEYSDRRRILAEKDIINDPFELFHHWFEVAKQKAPDDKWTETNAVCLSTATKDGRPSSRMVLLKGYDPINGFTIFTNYESRKGMEIRQNSHVALLFYWNYLSRQIRIEGCARKSSPEESDKYFHSRPRISQISARVSEQSRPIDSRETLIQRQQEEVKKFGDNIVIPRPDFWGGFHIQPERFEFWQGQSDRTHDRFIFELDPIERKWQQYYRIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAF3</accession>
    <name>A0A922IAF3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAF3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="69471" checksum="CD0E6D3DAD2DC2AA" modified="2023-02-22" version="1">MCLNHRTGMRLFQYFRNNEKLKKLFINEDLSLLHSAFKHQIELDRIRFDNDHHDSLLLETFSKKLLDNCKKIYSLSAVIAFAALIIAGPLTWTSSLIILFAISISITILWLKRNQTCQCDESIIKLAKQIDDERQLLTKLKELIEDNDCEVFNVITAISKLATSFRDIGIRCAKDFRQQTLALKELLPLKADIDDNLISSMPDDLYDSYNNCDVDNVRIIKSLRQLIRLQISEFFKRLLLIYVQNYYDVPSNFPEKLSNQIIIDTLNNILGKMLENSKCRQQELMTILSFYKSFYLSSSYDNDNQDKLKNENRMLWQNCRNVRKALYRSMAIIDDCETILDQSNTTAILDQKIKENLDCKFETMIETTTMANEMIQAIRRSLQHNHRKANITDKLELSTINDEMIGSNDNKPGTSGGLINECEPPKDEVFEAFIEDSRSRNTIWENDYDYDDDQTDVQMKDAENNMFFELRTALKDKHIEHRMREARAQGIELDREQIENEYRQSLMDNQTIPKQLMINDDNDHQMTTASAINSQFLEQHEQQSTTPLMGLNFQFDFNLAMRDSNQLKWRLNLNDGEETFGDSDHHNDHDDNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBA5</accession>
    <name>A0A922IBA5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBA5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="437" mass="51612" checksum="18B87EB99CB0C63B" modified="2023-02-22" version="1">MRKVQVIAYNYHMIMEGDQPHWYNIDQSRMTPDQRERFKRLERERRAREFMQYYRQTIISNLKPLAQTFYESQYYPKKRRTFELAGVNTYLRSRFCSVVSNRSLDNAFDNCRHRRFFHFNPKSTDSGPKNSQLVAVYNNQNLIHIKPQINITIPYDDDDEYFSYLLKPYYDPITQFNTINLIETYKDVSSLSRHDLYEIIDDRLVSKSSNRIRLGTNPYTCCHCTIGHLVLQAAHPKNACCIDFESDPNSNDDCAVIGYPGGIIEFVSLNWARNGRPKWRNSHQPRKNSRILDICKLDENRMIISATNHYLAQYDKRMFGRKAKPVVEYGKHYNTSHFHQINIDRKRNLIISSGSDDIVRFWNIDNGQLCYCLNLNEVDYFGTNNDYRLRQAYFAKDFSLYDASIPDRQSQPKIKGDTLIIADGDQIKFLANDMLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBC0</accession>
    <name>A0A922IBC0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DNA damage responsive protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DDR2_4</name>
        <name evidence="13" type="ORF">DERF_001664</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBC0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048525">
        <property type="entry name" value="DDR1-2_DS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21114">
        <property type="entry name" value="DDR1-2_DS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="12">
        <location>
            <begin position="130"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9527657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="891" mass="100393" checksum="870AA48F27EAB1F9" modified="2023-02-22" version="1">MMTRRRRRLVTATIAHHHSSPMYDHRQRHQNYPKIRQLTVHHFPVLIWLSFTFIWIISIQIAICSLQNNNVKQRIYGQPVSSVKNHHYQNNNDVDEQMGYPELYLSDTAFRRAEENNVITTNLCDKDGSIGIHALGMQSEIIPDSSLSASSAFEMLHVGPQNARLNKDKSGGAWCPSKQLGPDTSGTEWIQVDLDSLHVVTGVATQGRFGKGLGQEFTEWYSLFYSRQTMPTKWIKWKSLDGRTNLEGNIDPNTVRKHHLSVPMVAVRHVRIVPVSNHTRTVCLRFELFGCSYQGPISYTLPAAHEALARRNLNQLLDLSYDGSISSSGIWSGGLGQLTDGIKSLSAVNLKMKTREQNWLWVGWPKIADGSEASSVTMSFEFDQVYNFTSISLNCRNDFKQNIKAFTSALLWFSLDYQHWSHSAISFEYQSDDNAIDEFSRDIVIPLQYRIGQFVRIELIYTDEWLQLSEISFDFNPLPSNLTFDQKSQLFEWTHSEAYAASAAGGGTGSGTRYVMMAGHDNAIQNHSSDHHNNHHHMGKNKYPIGSDNQEGQALKYSLIIACLCTLGLVIISLLTSFVFKKLNLRKNNVFTEISDPTDLESENAAINMKNLPKEGGAGSSPLYCCPKEICSIQDEAEYAIPDVICPSNLSRTLALHTNDNHSGHHVVATANSIVCKTINPRFYASSDIIHAKQNIYGTRIQPPILDVGTHFRNIKNGSIQNVLHQRQTPLLDTFRNPNQHGIHCTPQRTQPFYVNDFISGTFGVRIYSESEIGVIQSLGKSKFGDILLCNIPATTSSASPATTTAVAKTRLVIVRTVNDLVLKNEFIESMDYQRNISQQHIDAFARLLGIIETPTYFASIIEYGDCDLNYFLRKTTTDILRYVLLLLPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBP5</accession>
    <name>A0A922IBP5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucan endo-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_001158</name>
        <name evidence="3" type="ORF">HUG17_4392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBP5"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08023">
        <property type="entry name" value="GH16_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="35"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7641348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9527115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="280" mass="32793" checksum="C3C10B8BB136725C" modified="2023-02-22" version="1">MNLNTFMMLSVFENIIQPSLSSAINGQRKNLIWNDEFDNTDRLNDNEWIYEQHCGRFNKELQCYTRHRTKNVRIENGHLIIEACVEPFNGYNFTSGRLLTRKAWKYGRFEIRARMPYGYQLWPAIWMLAKHETYGGWPTNGEIDIAEIIGNTADLMSSSVHYGPTEKTMISMTSGVKNFSIDLSKSFHSYTLDWTSKQLLWLLDDQPYYSVNLDRMMCCNDSNIKSPYNKKGQPFDQPFFLILNVAVGGTFFGPPPYVTPEQAKYWRKNTMEIDYIRIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBY9</accession>
    <name>A0A922IBY9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBY9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="97" mass="11192" checksum="E2B515E67E6A5861" modified="2023-02-22" version="1">MLSRYHVAGRKSTNSTKRCSRGEIFDESTSQSESILGRYLSTKYLISHPFTSQASRRIIATVELTVMKEFQFLGAIGTGKNRQYLSHFCKTYQILWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICI6</accession>
    <name>A0A922ICI6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pim1_1</name>
        <name evidence="15" type="ORF">DERF_002914</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICI6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000547">
        <property type="entry name" value="Serine/threonine-protein kinase prk-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051138">
        <property type="entry name" value="PIM_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984:SF25">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="430"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="206"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="296"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="713"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9529006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="742" mass="81261" checksum="D2F61832AE56ECFF" modified="2023-02-22" version="1">MCACNCLSSYKFLNCHSSQLPQHLHHPNCERYSRLSSQSSASSSLASSTASRSNSGAIAGFADYHYHHPHHHHHLFRGVNVGLGQPTAAMGVEDQLSSASSSPLSSSPYSAGSYLNSALGGQQQQQQQSLRAASNSISVHGGLQTRNGSIPLTNGISSSPSNQHHFNPSHHRMVIDSDTATAANCIPNSLSSHSFSCMLGHKTCSSSNNNNSQQLGSSSPSSSSSKKSLRKSIRRVESNSSAASLSGSNKNPNGGNNSTNMNSLGQGQPNRFLPSLFTPPTQYYLGTIHQMLFNQATSPSSSKQRHLSPSLNNNNKIKSSMNTNHHHHHHHHYNNNNHSRDHRLSASSTTTTSSSTQQPTSTVMPNSFQTKERTSMKPPATPTTDNPIMVSHHSPTLMQPPSLPPPSSNGRDVHNNNNYVRPREMFEKNYNVSNILGRGGFGTVYAGIRIRDGLPVAIKHIKRDNVTSWEQYNGRPVPMEVSLLEKVGHITGVIRMLDWYEDQSAFIIVMERPDNVKDLFDFITERVVLEERMARLFFRQVVEIIILCHKAGVCHRDIKDENILVDLRTMSIKLVDFGSGAYLKDSAYTDFTGTRVYSPPDRHSMVFRCLLYDMVCGDIPFDDDEAIIGGVLRFKRNVTSECQDLIFKCLSYNAKDRPTLEEILVHPWMGAKLDSSSTSIGVDIPSMDNSSSQISANGVAHHGGGRRSMQMMHFSSASVSGPESSTSSSSSSSPETPPGSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDK2</accession>
    <name>A0A922IDK2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPPP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDK2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032273">
        <property type="term" value="P:positive regulation of protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932">
        <property type="entry name" value="P25 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12932:SF9">
        <property type="entry name" value="TUBULIN POLYMERIZATION-PROMOTING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="178" mass="19782" checksum="BE10716939991302" modified="2023-02-22" version="1">MIIMMIMLKIQTKTPTESSSNESFVQLFKMFAKFGDCKSTGETITLSNSDKWFKQAKIIDPSNRTITTTDTGIYFKQVSKTKKTLNFKEYNLFLEKLATVKKIDLAELKNKLQQSGPPATNKTTTAVTSGAIGRLTDHTKYTGSHKQRFDESGKGRGKAGRVDITPNTGYVSGFKSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDQ8</accession>
    <name>A0A922IDQ8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">G-protein coupled receptor Fz Smo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FZD5_1</name>
        <name evidence="6" type="ORF">DERF_002883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDQ8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF126">
        <property type="entry name" value="FRIZZLED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="5">
        <location>
            <begin position="70"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="75"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9528973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="194" mass="22701" checksum="829483D1B3F00BCE" modified="2023-02-22" version="1">MITIITKGINVGEKYESLMKRTPPIKVNIMSSKFLGNFGGRLLVIMILNFWYYDPNVYFCQSMAILYDKNVRNRCEPIIIPMCANIGYTHTYMPNILEMETQQEAGLEVHQFWPLVHVNCSEDLRFFLCSIYTPICIEDYVGYIPSCRSVCERARIGCEPLLLQGGFQWPEQWRCNRFPIYGNRICMDPKKVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE94</accession>
    <name>A0A922IE94_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE94"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="521" mass="59984" checksum="E5CEED9A02108AA0" modified="2023-02-22" version="1">MSTNVEMDTEMYSEKNRLKSFENWPHDTGNITKEMMAKNGFYHHPDHIDNASTVIRVPIVAYVIPNLLHCDLIIGTDMLSRITRIDPLKSLKWKSKFGDIHYGPMVAIEHLKNDVNDIVDEENSDKHVARIDTPSNTGSFGVKYPFLSRVRPQSNPQKHYRGTIDDIRQCVFDANQMLSSGFELRKICFNVSIANGMPGENSMRKISEDSISSKYRDSLSSSVTKRIVLSTIVRIIDFSIFDHLKLRLQIMFSRIVPTGWNSSFKDVYARVLDESFVNWSILNQIKFNRFSPYTFIMYCLAVAIEPGLGYCLGSRFSFEKNKIASQMKTIVGKVFGSLLKLVETLNYIRKILSQSQTGLSIGIFLDLKIILFRSITSSNRFECHFGIRLRRVRQIITDCRIPVIFISGILNLADMFILPILVSKFLHQKPRHFRSINFLNDSYPFNMIRWIISSSLSFLVKNIYHEASNGICHFCFKVLYANLYLKSSPGRLNFVSKSYPLLVTWNIANAYRFDSITKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFG2</accession>
    <name>A0A922IFG2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Enolase-phosphatase E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ENOPH1_2</name>
        <name evidence="5" type="ORF">DERF_003079</name>
        <name evidence="4" type="ORF">HUG17_5099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFG2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01133">
        <property type="entry name" value="C1.5.4:_Enolase-phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00044">
        <property type="entry name" value="enolase-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7642054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9529185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="259" mass="29842" checksum="3916647D967A4408" modified="2023-02-22" version="1">MAEENQNLVKIKRPKIILCDIEGTTTAITFVKEKLFPYVRAKLRNYLIETWDTDTTRNDIKLLFEQYQKDMIDDQLFDLRIGNNCSFDIDTVCVYVDWLMDHDRKVGPLKQLQGHVWENGYNTGQILGHVYDDVSRCFRRWTSKFNVKIGIYSSGSVLAQKLLFSHSIHGDLTPFISYYFDTNIGPKQSTDSYRLITEKVGSSATDIVFLTDVPKEAKAAKESGMMAILSERDGIFLTPDDKHTFNSITSFDKIIFLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGJ0</accession>
    <name>A0A922IGJ0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_003253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGJ0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037025382" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9529364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21469" checksum="8774731811514CBE" modified="2023-02-22" version="1">MDHQRLIIVILLFLLSNHYHLAVAQDTIFAKGGTCLYKIGKQWQECMDQQSERLTYERDNLEPVYTRAALTESVNRISCCAYYEFLDCIEYAARQHCPHEKHDMIAYSRQLGSAVPSDICHEQFPRQIIECSGHIQRYSSGASSIFYLSSLLTLLLPSLIILLYNNETRDASFLCDVKYIAIDLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGL6</accession>
    <name>A0A922IGL6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGL6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="146" mass="17220" checksum="A19DA74A5D76470E" modified="2023-02-22" version="1">MDNSPGWARIPLRCASYDEPTVIYRLSIGHGLVVLESRFYSLVLFFIYTRLVQLTLILGLIKRSFCDNTDVVILIRWFYHPKFLFLILLVRCRYLLDFLSSVHNLILLFCMLIFVFTIVDFSILRILVNFMLNTVVLYDGRSFLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KW32</accession>
    <name>A0A922KW32_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_016046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KW32"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9491318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="606" mass="71285" checksum="978587ED096D4863" modified="2023-02-22" version="1">MDSRFFSRNLPSLCSSAKSSSTHPLSLSSESPSKDELNQIKSLNIQHSIHHHHQNHYYSINFASRLILFQTFLGTTYRGSYFHYFSHSKFNHKCLKWLSCLYEMITFIGILLFMRNTFDNSIFQSMFNYTNKTYTMIFVFKLTGFCLLLEQIVMKFMTLFHGYSIVGVVYKIAKNSHWKKRYDCRFMYLYASFQLSINIIGFLLITNYVGYSIYMKIAYVAGAIIFGTSKLSVATIHSFVSVLINHRIQDWKNRFHQYQNYSKLLREIIEQRNHLKELNQRLSLIMFVKVIVNSIELASLICFIEDMYSTGQDSVIIMAIFCFLLSTWFELFINFNFNVMGFIVLCNVTLLTILGNVLIQVFEPTNPINVIGYNNNLMMMAKIYHCESHSKRLISSKIDKQLYRIILFQTIFDCTYMGEYFRRKNDGKKFQKYFTTLFAIIQETIYGIPAALLWYLSATSYSADYLFEETAVHNTMRYLFSLFHFCILIETLSVKLTNIFRGHRIIAIIQDIGNVGLANLNHIHYQQYYQSDKQRRQSIISNENNMMTRFRPLISNGEYHCLEQICTMHNSFYFIVMEMFDLKHSTMLSLVSYVMSNAILLIQTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KW93</accession>
    <name>A0A922KW93_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proline dehydrogenase</fullName>
            <ecNumber evidence="5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_014097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KW93"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000012">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="325"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9493345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="620" mass="72579" checksum="984F5E2808192C9A" modified="2023-02-22" version="1">MLRIDNCFNRLLWSGFNSIRSSKTPVVTASHPSIICFIQNHQIHHHHHCHTRTLSSTTTTTTTVGKNSIRDKLDLTFSDTEQAYRSKTTFELIRAIAILYVSSFDTLVFNHDMLLKWSRRLMGERLFHYLMRSTFYGQFVAGKDQDDMKPVLDHLRSFGVKSILDYSAEEDIEKKFDKISDKQKGKEKAVKQYEYDDVVHGRREYRPVARTYFYMNEAQCEKNMDIFLRCIDVVAGATYGTGFAAIKLTALGRPELLLQLSEVIARTRKYFQQITGQNSMGLGNITPEEFQKQLDQRFNLNVDNTEIATFLKRMDYDQRGLMNLFAWNGLIDMDTLINDLFKVPNLRTGRLEMIINALNQEEEEMFRNMMRRTHTIARAATENDVRVLIDAEQTYFQPAINRISLELMRKYNKEKPIIFNTYQCYLKNAYETCELDAELSRRQGFYFGAKLVRGAYLEQERLRAKQLGYDDPINPTFEATTAMYEKNLDFFMNKIIDTGIDKKKFAIMVASHNEDTVRYTLKKMQELNIKPEHKLICFGQLYGMSDHLSFILGQSGYSVYKYVPYGPIDKVMPYLSRRALENHGILKKAKHERKLLMKELFRRIWRGKLFHKPIGNYQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KXL7</accession>
    <name>A0A922KXL7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KXL7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="382" mass="46004" checksum="5E41F0C995064328" modified="2023-02-22" version="1">MSSLEESYQKRKKALRKFDDYFNSLTDGHDEELCLEKMNIRQLIEQIRSFNRNLADDDNLYEDELVEQFNSRAHRLAKFLNDSTDIGMDEELPKKMMINKDIQIKPSQRQSEPRMFQNDDFDLNNENDHIDSLLTIYYIGELELTDNNWFDYYPKLMEFIVRDPKIPDERTRINYLKQTVQKNPKAIQLIKDERSIKNATKILEEHFDDWTLQKRALFIKEMIEKFHFDKNRESDEANFRQLLDIALHIRFNVSEEFQQKYFPMILFKLPNWIRARTLSHFIRMMRAKLRIYDAQHVLKAGTYEELEKLFDRLIVNGRPCPICYHLHNQMKAHPIVRCRHLNEFRNKYNNRNSNNLTMSMADLSISSNQLSNDQSGRSNQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZK3</accession>
    <name>A0A922KZK3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZK3"/>
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    </evidence>
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        <source>
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<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637545.1"/>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAH7637545.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9501976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="186" mass="21071" checksum="0911EBCD9F1749EA" modified="2023-02-22" version="1">MSIRGNIKKVLFPHIVKHIVISLCGASIFFIGYLMFDLISTLVDEIQNSPSNSSNMHDGGHKSDDPMTTGKVLYYFRNFFMLMLFALMQLFGLVGALKQNRNILSTFICCLMVAFVMMVIDYLTNTGYLSLGIFFLIQASFAYLLMILNQYRGHQISNIHYIPMPDEDVGSIGHRPSIVSSDSMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1H8</accession>
    <name>A0A922L1H8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009990</name>
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    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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            <end position="81"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="207"/>
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    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="ORF">HUG17_0101</name>
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    <organism evidence="3 4">
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1K8"/>
    <dbReference type="OrthoDB" id="9987145at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617:SF14">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7644563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="479" mass="55236" checksum="9FEC86ED1CA381D5" modified="2023-02-22" version="1">MSTTAQTISRLDTIYRSILLSKFFVKGWGNPQNMKRIFKFRKIISNRQTCQKLVQSNHPIYIDRKIEQTDSYCLYEGHFNSPLVDYLAELVPKESHVAYFQLIVPSYWNTDNRISQQQIRPLCVQLAGTGDHGFWRRRQFMAKPLIRDYGIGSIILENPFYGLRKPNNQSRSQLNNVSDIFIMGGCLILESLALFHWCKRMKFAPLCITGISMGGHNASLAATSWHEPIGIVPCLSWTTASCVFTQGVMSGSIPWKILETQYLSYPDQDRVELSELLHTPEKYLNDEMFDAGRSFAKHFQFNFNQFLTELNMSLSLYLDKIINFKFTQNQQQQNGQHNNNNKQQQQQQSTTTTTTTTNRDAAFFMRGIMDECTHLGNFSPLIDPELAIIINARHDGYVPSQGVMSLTDIWPGSQVRYLDRGHISAILFDNDEFRRAIAESIQLAARKYMNIDDIFIEHRQQQKKTIRNVSKHNGNDDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1T5</accession>
    <name>A0A922L1T5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chaoptin-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_012523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1T5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050328">
        <property type="entry name" value="Dev_Immune_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373:SF370">
        <property type="entry name" value="FISH-LIPS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24373">
        <property type="entry name" value="SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037266076" description="Chaoptin-like" evidence="5">
        <location>
            <begin position="23"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1073"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9501695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1122" mass="129188" checksum="B3A6343AE600972C" modified="2023-02-22" version="1">MTNSTTITFIIIIILCICSIHTNDEYKCPKNQFYLYPCRCTSNGFSGIDLQCENSNLATISLALENVKTPINHLMINNANITRLFGPLFKDKIIQSLSIRDSNLQTIDYECLNINTNFKSIQLDGNRFISIPEAIGIELSNLTKLTVINNKERIINEIKANDFKKNVQLIELNLRNNSIAKIDSSAFTPLTVLEKLDLSHNRLKKIERNQFRANKKLGYLDLSYNDFKELGKSDFNDLVSVTTLNLSYNDLREFPRSIFGRVSQLKVLNLSGNKFKQIDSYMLRGVRFLKELHAGHNLIEGLAKNSFTSTTRIKLIDLSHNLMTEVETEIFKDMQWLDLIDLSYNHINKIKKGSFQRMFKIAIKLNNNNISTIEYKSFQELSNITELDLSNNQIETLRANIFDECDCTIFKLNDNQIRNLSNVDIFANLTGLRMLNLSRNFITEINRKHFTTKKLYELSTIDLSYNNITEISGNVFEKFVSIRQIILTHNLIGKISYNAFGALPTLLELDLSHNQISEISNGGVSNLLSVKTIYLNDNRLERMFPVSMAVNTLHLENNRIQSIGSNMFPMINAVLAIHLDNNNISQLDDNSFRQCLSLNTLTLKGNQLTEIPQRALAPLTSLQKLDLSFNHLKNLGRNAFGTLNILFELDLSNNMIKNISENSFEGLLQLLALNMSHNELNQLTPDVFNTLVSLRTLDLSYNQINNLDNGTHSLFDQLLSLERLNTSHNQISIIKDRSFPYSPWIPYKLRHLDLSYNTIPVLTSHFDNGLSKLNWLSLKGNIINEIYPNTLGNLTELEYLDLSENDLRKISKGVLQPIPRKLKELDLSFNKIKSLFVDDIIAIPSLIKLNLNSNRLSHIDEELIERIKQNLTIYFDDNYLHCDCKIMTLVSWIFSQHHQSKLEGKQSTVYEHWRNLQCHEPLYVKNKFMVDLRATMVDCDENERDSYGKKFTSTSSIRIRTIDKFRKRRQESMRIVWFIQNQVEDIASFQILLRSENNPNDYFVNEKVNYLKRSFIVNNNNLQPGNRYVLCIVPIDSMGIMVHSNGDENFEQNCIHFFNSHAHVIIDGDQTQQQQQQSRQKLSNAPRVQKSNHHYQSSSAASFSSSRILISHLILLSITLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1Y4</accession>
    <name>A0A922L1Y4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1Y4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="106" mass="12026" checksum="AB1C53EE273E931D" modified="2023-02-22" version="1">MELNDSEIEDFSNPTSQQLPVNNQTIGQHNHNNNNNHHHQTHPLQHNHHHTHNRILDYEIENDDHMVVNNEIEPQQQPPLPPPPQSSSSSSSSTTTTTIPRNNPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2N8</accession>
    <name>A0A922L2N8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2N8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9512122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7497" checksum="58430AAF28097159" modified="2023-02-22" version="1">MFVINIEYSNVYLCVKLTNNNNNKKTMLFQLIIHYYRPEDVYPIKHPPLPQPPLLLSSSQYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L308</accession>
    <name>A0A922L308_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KICSTOR complex protein kaptin-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L308"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029982">
        <property type="entry name" value="Kptn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15435">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN KAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15435:SF2">
        <property type="entry name" value="KICSTOR COMPLEX PROTEIN KAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="53028" checksum="8F8F0EC3A420E5FE" modified="2023-02-22" version="1">MEQIGFFPISNSSNIYGMTNMHGDMTRILVATLEKQVFAVEYSDNKKITCNEIHFAYIPNSADIISIDAFVRTNYNDIVLGITFFKNYKESDSNEFRKNIVVSNNRSTSSSSEKNICNHYYFNIYSSLSSTNRFDLNQIAQDCQTFELDFVPYHLYHTSIINENNIAETLWLLSGSDCYVHVFREDNKKQSFYKDKIDLFPELNNFESIVIWIDVINYEENHKCHRLTAVGCENGILCLFFVELGETNNPRIIKSWKNRFDGPILSVKFFKDKINSNLNLRKLGFKSEFSPEIHLLVLDSCEQPTIYRNVQENGLGLRKILPKINENNIDLFPASIVGDVNFDNNNEIILGSYGKKIIFYKFEHESQTYFIENTMEVPHPVISLTYLDLTGDGINELIIVTTKGIVIYRHHIDPLIDALVKKMNTIAMVKPSAPDKSPDMAAANVDTRNNRSASSTCVSFTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L364</accession>
    <name>A0A922L364_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L364"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037056916" evidence="1">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="90" mass="10980" checksum="BD17F5E07EA7C554" modified="2023-02-22" version="1">MEEFAFFILIYSQFFILMAQSLNCKQIKSYYDTRWKPEIWLKNQTNLQEFLLDSYSSILMSNKQKDQNTTYVEFILIDFIDNSQFSQIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3A9</accession>
    <name>A0A922L3A9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TMTC3_3</name>
        <name evidence="19" type="ORF">DERF_012271</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMTC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3A9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44395">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44395:SF1">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 16" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="18">
        <location>
            <begin position="257"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="16">
        <location>
            <begin position="574"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9501423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="842" mass="98808" checksum="074EF82DE0F8EDAC" modified="2023-02-22" version="1">MTRMKSSSSLFDHIYPYIVITVTITIVFHNSLDCDFTFDDTSAIVQNRHVHTNETDWFRIFDVDYWGTPIRSEHSHKSYRPFTSLTFRWNHLWSPALNPYEFHLTNVLLHIIVSFICFEFLRIMLGPQNRWPACLFTLYFAIHPIKSEAVTSIVGRAELLSTLFILISLFCYFKNAYINFAITVLLASYSKEQGMTTPAICIAIECLKLMIQFKSLNYLPFWSRLWHSLSNLTMAKIIALIAYTAILIGTRIYLAGSSLPIFTKFDNPASFEETPSRQLTYNYLLPLNVRLMLWPRWLCADWTMNSIPLVKTFDDSRNAWTAIFYLVFIILSSRAFYLATSKQSKRLFNIEIDIERSNLLISLILIVIPFIPASNLLFPVGFVLAERILYTPSIGFTTLLAIGWLRIQNYFQRSRFIQFLLNFSTILMLVTFTFRTYERNFDWRNDLTLFKSGLMVNPNNAKLYNNIGHYYERRGEWSEAIKYFRLAADKDHEDIGAELNVARSLIRLNRLKDAEDLLWAIKPRVRTSILKNRMVPQYLNIWINLAHVISMNQTRLHEAENLYQEVLTIRSDFVDAYINLGELYIRKQLFDQAQETYEKALQRARHIDDGKRADIHYNLAIAKSLKLDHQQQKPSGSKLGSLLTEIAQDLMIAIDINREHREAIINLAILLQRPQFPSNNQNEYRTFAINALRSYSRSNELESFQFNIAITLLDIGGPTNRMDAIHHFKRAAELKPDFRSALYNLALLYYDFKDYEQSLFYLNRTLEHYSNYTKALLLTADIYSRMERLDDTEKTYTKVLEMDHNNYEAIHNLCMIYKQTQRKKEQEKCLLMLNDFKLKSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L443</accession>
    <name>A0A922L443_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L443"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9505989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46816" checksum="6324821FE7E9B945" modified="2023-02-22" version="1">MLASYNIIVYVNVVQSYQGGCQCPSRFNCHDYLDENNAGNLRGGKPVMDSTIHNHHHNDNDSDTEIRGRSLETELDYYNKCHYNGTSYNIGEIVPTENVCRICVCSYMSDGTLNVDCPSKIECPTPEARGLKMNSFHFTPITLIGGINGGGGGGPQSIQRYRRRPLRQKQQQKRNPNGEPESISSLSLYCYDYYKHDQCCPRQECIPVNSRTGRTIRPRKTCHYAGKEYQLGEKIHLSDIVDHRLTTTTVTNISESESDVENRIEHNGDGNERTKLAEIIACMRCICTENWNSSAIEARPDQLPSLLDADQISCRRKSCILDLDPRFRRGCIPVYDPDKCCPVDFICPRTRQMALRVRGVDYGSKLCHFEGRKYPVGARIYQSRHQAADCVDCECRIPPEFTCLKRKNCQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L492</accession>
    <name>A0A922L492_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clotting factor b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_007196</name>
        <name evidence="7" type="ORF">HUG17_1649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L492"/>
    <dbReference type="OrthoDB" id="6489948at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000036">
        <property type="entry name" value="Trypsin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S1" evidence="6">
        <location>
            <begin position="52"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7646111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9516460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="283" mass="32385" checksum="A702FB34F6F7D20F" modified="2023-02-22" version="1">MYRIFILSFLLYKSDNIHCDKFIVIDNIEFIVQVKNSLSLPGCGLSGHFERIANGQNSLDGSYPFAAMLYRYSIPFGGAVIINERWLLSAAHNFRDSKQSSIYSIGVGSINIKRLIMKKIDRIILHEKYQGRQKYDLALIRLKEPLRFGQTIRPICLPDYSFESLNNLKKGRAIGWGYRNFTSYKVSQILQEVDLDIIPLNECRSIYSKLKQDIIHSQICTYTMNKDACSGDSGGPFFAYRNDRAILFGIIDFGVTCADNFPGVNTAVSHFLHWINRILIENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4B4</accession>
    <name>A0A922L4B4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_007270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4B4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036719350" description="acid phosphatase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9516535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="399" mass="47163" checksum="1592FB38B28D3643" modified="2023-02-22" version="1">MLKLFFTSFFLSFPLIIVDCSLVLNSVSVILRHGDRNPLYIYPNDPYDETYWKQHGGVGTMTEQGKNRIKIAAKFYRQHYEMLLQESDGTNYQVITSTVDRAIETANIFMKEINKNATFQRNDNMLFMYAKCDKATKLRDDRLNEIAPELLPNNTFMDYLRNKTGDEFTDEDTVKKIRLLFDLADTLKIERDQLNMNVSDWITDKETVKTMSETERKIFAKMSNTPEIQRLRVGLLLKDIRDQMEKNPSQRFYLYSTHDFNQAVLLQALDMYDRLDKINQMPPTYVSSVVFEVFHNETNEQEKWIRFIYRQFLDINGTIMNLDEKILPEKCQDELEFHDGTVLNTGKFCSWQQFTNELLKDLIPDNWDKECQNSSFANKPMWITLMIFITILMSNFSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4D3</accession>
    <name>A0A922L4D3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4D3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="324" mass="36343" checksum="96950FF1DACD7D7C" modified="2023-02-22" version="1">MSRISSLSLSSSDLPPTTITTAKTTNKRQTTIKTATTTAEEENEAFDNIQRSSSSSSSLLGLTQKLFHAFKQAISSMFVCRLLTNLISVSRTTTTNVKTNNSNQQQQQYWWWSSKSSSSNHHNHGSSSFSFLSSSNSSSYDINLFESSSNLSNDSVFVEKNNTNHHHHNDSSSSSPSTSKIQTFATSSLAQEANEFSSSFSKTKTLIGERLNYSEKDEKKKKSKSSSKSSSSTKLSRAFDYYKSICNYYNKDSTRLSTKDKFSFDMEHIHHPDDDGDGNSAVDISNPQQQQNDLLARQKRFKITEKQLTYLKHKIVSLSIILFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L548</accession>
    <name>A0A922L548_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcript 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DDIT4L</name>
        <name evidence="5" type="ORF">DERF_011801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDIT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L548"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.40">
        <property type="entry name" value="RTP801-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012918">
        <property type="entry name" value="RTP801-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038281">
        <property type="entry name" value="RTP801-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478">
        <property type="entry name" value="DNA-DAMAGE-INDUCIBLE TRANSCRIPT 4 PROTEIN DDIT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12478:SF16">
        <property type="entry name" value="PROTEIN CHARYBDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07809">
        <property type="entry name" value="RTP801_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9507099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="500" mass="54796" checksum="310C59D76402DC67" modified="2023-02-22" version="1">MTKSSSFLITESNDQISSSSSSLIIKNDKKCCQSTTTTATTKQPSSSSSSASTLKIVTVATPIIGDINSSNNCVDSGRGGGGVDCSNNNIQSPSLSLSSTIWSNQSIKTIAKTRMASMACNQRLSSSILFDTNNVNRIGHTSSSSSSSSSASTTSSSSSSSSSNGVDDTNIDVNLLNHNNVSAMKMPPMSYMNGNSVRPIRRRHFSQQQTGGIYVNNDGNGGNGNGGGGDNCNQNGIIDTNLSMNYDNNIYEWNNRNKMIINTNDNKKVSSQANNVANTTTTTTNSNKTNLIDKYDDDMSTKTSSSSSSSSSSSSSSWNYFIDNNHHTANYNDEIIVRLAKGIENILRLAKETRLVHCTEILIPQMLMQQIVTNVIEMAECEPCGLRGCLLLIFIENDDDNVVVNNNNNSNSNNNNNNNNRRRPNNNNNNHQYKMNTSSTKLLGEFVIDPDIVPTFEVFLTLKRVKPSWFESLEYRFFKRTPIILSEIYLLNKKKLYQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L696</accession>
    <name>A0A922L696_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L696"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="204" mass="22207" checksum="5714F064B7C268EE" modified="2023-02-22" version="1">MTFANMTAASCTAATTTTYTTISSSSSSSLPLTSTNPQLQSNLVSDNVNDDETNDDDDDDDDDYHQNHYHSNNSVVQQQSLYPKILYSKCPTKNIPSSSSSLTTTTTTTTTTTTTNNIHDHLTTIGATTTTDGCCGSIIGVHQLFRSLFYCLNPNVTTSTTKTNATNSLTNHFDRRLKFRTTVPLKNSKQQQQHTAAAICNTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6K7</accession>
    <name>A0A922L6K7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6K7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="7061" checksum="032E57729D4BDE0F" modified="2023-02-22" version="1">MHRTNSPPETLINKVTESSSSTTTTTTTTTTTITAAAPAPATTTISIVASSSSAGSYRLLQLPYAAGGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6P3</accession>
    <name>A0A922L6P3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras- protein Rab-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RAB3_1</name>
        <name evidence="7" type="ORF">DERF_004958</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6P3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9521288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="232" mass="26998" checksum="A89999870072AB0F" modified="2023-02-22" version="1">MCSEYHHHHHHHHQLYLSQYSKYISSIECFKELKDQKWQKDTVDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRQDKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMVTQIKTYSWDNAQVILVGNKCDMEDERVVSYERGKQLADQLGLEFFETSAKENINVKAVFERLVDIICDKMSESLDSDPNVMNASKGTRLAENPMPQNQNCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6S4</accession>
    <name>A0A922L6S4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6S4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="137" mass="15664" checksum="8DA428AEBDC155E2" modified="2023-02-22" version="1">MSKRKFIVKSTNAITQVTESANDLTNNGNSFYVWNIENGVETLKRFSAKEIFGEDMKNGPIITIKGPQDTVDTLLKDLFPDEQTFGIWLTMETRHVFGIRNNFKYPVRTLDFSILSTKPKTTKAPGYENFLFFSAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7K4</accession>
    <name>A0A922L7K4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_006318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7K4"/>
    <dbReference type="OrthoDB" id="6490487at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051368">
        <property type="entry name" value="SerProtInhib-TIL_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259:SF70">
        <property type="entry name" value="ACCESSORY GLAND PROTEIN ACP62F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23259">
        <property type="entry name" value="RIDDLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037011693" description="TIL domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="TIL" evidence="4">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9522759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="94" mass="10560" checksum="5F611A836B614CBE" modified="2023-02-22" version="1">MNMKIATILIVTLFVAITMADPIQQTCHDNEEWKECGTKCPDTCLNRDIKHRGCVQMCVAGCFCRDGFIRLGYDMTGGIGHCVPVDYCDLIQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7T0</accession>
    <name>A0A922L7T0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_000543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7T0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051738">
        <property type="entry name" value="SAF_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683:SF8">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15683">
        <property type="entry name" value="SCAFFOLD ATTACHMENT FACTOR B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="163"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="499"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9526451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="554" mass="63026" checksum="E208114D62D51F68" modified="2023-02-22" version="1">MASYDDDEEYSNDGGGGGGSRNGNTKNDDQSFIMDDDVPSDIENESDDYQSRNDDDDDNEEEMEEIENADDGQSDDNEEEIVNNDDRRKRKQQQQQQSSSKSDSQSKKSGKFIIIIINNNNEKIMTVKRNHHRHHQQQIEIMFEEKARDPKPRSKKVDLAKTRYLWVSGVPVGTKSTHLEEIFSKHGKVLAIKIIRGNNNSLLGFVKLESHDQAQRCLDKLNKTDFRGSKIELFKERPDDKDSDGKKLEKIGFRDSRKYIAKPPIPKRPPTSSFRPNTRGGSFHRPQHRTSLPSKLRRTPPIRLSSSGSHHHDRRNNERDGGSSRLDRERQKLKMERLRFEQEKAEYFKIEQKSRFEFERGGGGGSSAIVGDLRSEDKTGPPHRIRSMIKRNVGGGSFDDGSPFMHHEEKRYDDYNNRREFNSIRRYDSRESPMERKINPRSSFGSITGGRNSYDTGSRPDHRYSDLGNKSWQPSLDSWMTTGLSSSIGADNRGWNSSTGYDHHTTPRILSSSIGGGTSGSMSSSRLNHSSDMNPRGHSGGGGGGGYYNNNRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8T2</accession>
    <name>A0A922L8T2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8T2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="96" mass="11191" checksum="E1CFE6624D3C8313" modified="2023-02-22" version="1">MFFLSIIIIFLVRDLIEKLWVRWTNDFLNLSASVFVLVVYVDKYRCGIGGGGGDDDTKSSGFFHSHKNLLSNTGKKIFFYSFPKKFYLIIIFLFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8W2</accession>
    <name>A0A922L8W2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="27">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">DERF_001688</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Derf</strain>
            <tissue evidence="27">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Derf</strain>
            <tissue evidence="27">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="21" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="20 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1745"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1780"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="26">
        <location>
            <begin position="445"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="25">
        <location>
            <begin position="1727"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1330"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1373"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1564"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1635"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1694"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1839"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1330"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1375"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1577"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1635"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="1657"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="1696"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1723"/>
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        </location>
    </feature>
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            <begin position="1847"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="23">
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            <begin position="1869"/>
            <end position="1898"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAH9527681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1935" mass="219948" checksum="02150FB257FA7631" modified="2023-02-22" version="1">MQSSLSTILKLRGWKNYHSWENCIYGLLAQHGFYQLFNEDFNQTTMTASERAKAAGIIITSLDEEVARKITVSHRMDPKGLLKFLKDSYGKSEASYVSIGISLLNLELNDISDIELFLENCKNLYNDINKLASEDEKLCEKFFVTIVLAKVKSKFRFITDLELNPNATINMATVFGKMISEARSIKNNQSSSDIGNSLNVMSVSKNNKMFCSYCKRTNHTIKSCFRRLRANNQNQDSSSSSSSTEPQSDHSDKFKNASGVSIAVNSFSVNQYRNNWLFDSGADNHFCCNRKLFKKIWKINKISISQFNPNDHITCDEYGSIDITTDTGILEIEAYYVPQGQNVISVTRLSRYGFSVSFTKSGLKITKDNDLVWFIENQTHGRFFSACPVQSSSKDWHNILGHADFNKLKILSQKYLFVQSKPYECDVCSANKMCKPKFEKSQHHHSKSPMEVVYADLCGPFPFSIHNQKYMLVIIDQFSRFSQVFFLKDKSAASVHSYIKYFIEFIERHTNFSTKRFVTDNGGEFVNEIVNNYFRSKGIIHVTTTAYTPQSNGLVERKNRSLLNMARCLLNHINLPKKLWPYALSYANEIQNRLPSANNNQIPFETVFNSKIDFNKFHMFGSKAFIKLDHFENKLVPRASPVMFIGLDHSKFIVYDPKTNKITSSRNIKFTDEIYSIQDPNYETSSIFSNFIQQLDYHSKQDFDDDNYDSSDYVISEIPIIDNQTPDFNINLIHDCNSSTDEMSNHASLVNQQSDDFSASNDDLSVSNSTNDSEATIENNDLPIAWRKPDRSVKIPDRLGVAASSLSSLSSALPSSSDLFSSSINDSIPIPKNYKDAMNSPHKNQWLAAINDEIKSFHEFNVLSSVPNNNQPTIDSKWVFAIKRDVNGKIEKFKARLVVRGFMQEDVDINDTFSPVVDKTTIRSLFVLAHRFNWHAIHLDVKTAFLHGKLDQDIFITVPDPLKTDGFIFKLNKSMYGLRQAPRVWFNTLVDHFNRIGLVQLDANICVFSDGCSNTENSLIIACYVDDILCFGPLSKIESFEKRIGDVIKIKNLGSVQKYLGIEIIKRNDGFHLSQSKYIESLSVQYQVNEAKYVKCPLLNSLLVDLNDKSTNFPIRNLIGSLLYIANWTRPDICTAVNQLSQYLHKPTDRLWRHALNVLKYLNSTKLVSLCLGSKSDKIIGFADANFATDSTDRKSVSGIAIFLFGSLVDWTSSKQKIVAESTSVAELIALHGCVKKLEILYCCLVSLNMKIIIPIEIYDDSQNVLQRINNGLSKAADVKLKYIIEQMNVGLIKLKFIPTTEQIADPLTKIIIRDYDNIRKNFAVTNSTTTTTTTTTTTGKTIKINNNNNRNNREMFKDCVSIKSSETVSAAVAKQQQQRQQYHHSSSSSKSSSSLNDKKRIEQQNNNNSEQNQFKTNDKHFHHSTNVHMDKLSVKNHRRKKSNIFFNEQQKLVKKSIINDEYDEQKNEQAKTSPNLLSSSSCVEINQNNKLLSATTSTSTSSSLSLIESQQKPSTILIANKISEELPIEYEQTSYGSSTNYSLSGNNNLSLTKSRFLLIKNLNNNNKKKLKKNNENKSSSSSSSLIHNGLRMVSYGRHRKNDHQSSSRCKRLTNNSSFYDSFRMKSFRFKSLRNQEQKQNGNNNDQIDSIETTCNENDDDDDDDDADQIFVNANNADDGLSTVVPVSDTDDHCKCKNKNNQKQRQRQRQRQQSSTITAAQKHRNELKREESSRLRQEKKAARQLGVILGAFILCWMPYIITYVVTAYCAYCISLTVHQVTIWLGYLNSFLNPFLYALCNENFKHAFKKMLGRLQQPQHFSYNFDQTLATAAAAAATATGGGGGGNNQNQNYHQQSATTRGNNNNSVRIITQQQQQQQQQNNNDNSTTTTTTIKTPKTTTTATMKRIIITKTIDNENENEQNKMKKKNLLNIRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9C4</accession>
    <name>A0A922L9C4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_002145</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9C4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043068">
        <property type="term" value="P:positive regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21889">
        <property type="entry name" value="SARAH_Hpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000040">
        <property type="entry name" value="Dual specificity mitogen-activated protein kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.170.10:FF:000002">
        <property type="entry name" value="serine/threonine-protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.170.10">
        <property type="entry name" value="p53-like tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024205">
        <property type="entry name" value="Mst1_2_SARAH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036674">
        <property type="entry name" value="p53_tetramer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11629">
        <property type="entry name" value="Mst1_SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="13">
        <location>
            <begin position="432"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9528176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="486" mass="54999" checksum="820AE26662FA2258" modified="2023-02-22" version="1">MSLEKLSEQQLTRQPEEVFDILCKLGEGSYGSVYKALHKESGQILAIKQVPVESDLGEIIKEISIMQQCESLYVVRYFGSYFKGSDLWIVMEYCGGGSVSDIMRFRKKTLTEAEISIILQDTLMGLEYLHTHRKIHRDIKAGNILLNNEGHAKLADFGVAGQLTDTMAKRNTVLARHFGWHQKLFKKSVMIALADIWSLGITALEMAEGKPPYGDIHPMRAIFMIPTKTSSFKCLVKNPEKRATANELLQHEFIKRALSVSIIQKIIQEAKEIQQNQQQQQQQNTSSTFGDNLNATMVSAKDVTLRSNSNYQNNDGNRTADSQMNRTAGTNFTTSDVESDLGTLIINDETDDEDSDKTLKPAFLQHFELKDKQKNYKSDAMPTMDDTLLEHPAKNGWNGNSDESNNNSNNSSVLSSINNNPLSKTILLGGDFEFLRLLSLDELKARMANLDLEMEAEIEELRRRYAAKRQPILDTMDQKKKRQQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9Q5</accession>
    <name>A0A922L9Q5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9Q5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="219" mass="25040" checksum="9D75E20C501716F0" modified="2023-02-22" version="1">MMIDLDQCLPQRIHNNNNNHHYHSNHHHHHHYSANIQHTNYQHQNVQPNSSTTATTIDSIGSHFHQTMPTTQQQQQQQQQQSNINNSLSEFMTNNHHHHNNNNNNRQFYNQQQQQQQTELMYNNNSNGKVKRCHNTNNNSSTLKLIQQNQLFSSSLNQSHHRHHHLSSPLPQSANIRINQMTMNNNNSISSGAVGKSITPPPLIMSSTTPSSASSSSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9T5</accession>
    <name>A0A922L9T5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9T5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="482" mass="58275" checksum="EF53D7EAC83E4478" modified="2023-02-22" version="1">MQYRFFRFLYTDLKDIVHLYHDRNYRLRHKWEMILLFILIVRLSFVPLTRLKFQKWCSVWNYDPISVFMINEYDQLYYYLFVICLMLFILGIIATNIFHFTTPVDTCTMLYPYDLIVRNFDQFQQCILDDDQKKRIWQTRFDHNMKWFIGRGHLPRMITEFACRIWTDCQYRLYFDHIDKQLMNGKFRLVYFPYIEFRARRYLIILQILLNSSFFVLHVIAFPIMCLLFAQYYRGLAEQFHMNRWYNKIWFAIEVITLTDAVYTSVECGLLGAGMELIIGAFHYFLINKWNPSLKSIRIQMNAINTSQRRRCQMNRELSKIHRDHGRLSKIYRKAFSEAWGSILLVYLMISIPMNVSIILLLRSGILETFEYMSGFVGIVVHTIITMVLIVPMCFEVETLHQTKKDLPAIVPNIRHIRLKLKYDDWYGRLIHGPKYGPVIATLGSITYKMALESIEESLKELHFRWYRFYRNINVFSRVRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA32</accession>
    <name>A0A922LA32_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA32"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="76" mass="9535" checksum="B74DFD6953BCF6DC" modified="2023-02-22" version="1">MLSQRMAEKSEFIRFEFVNLQFTIYRNKLWQIFCHNNNQMKLIDCNFQFKWINWIAKELKWKNLVTVPVQFDRFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAL3</accession>
    <name>A0A922LAL3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAL3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="75" mass="9148" checksum="5B2E74C5C7D3448C" modified="2023-02-22" version="1">MFIIIALRKFRILNLISSFHSKFLDLFCVCRLNFLFLFPVFFWFYFLVIDLNESNEFIDHQYEKDKLKKKNSNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB86</accession>
    <name>A0A922LB86_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB86"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019308">
        <property type="entry name" value="TMEM214"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10151">
        <property type="entry name" value="TMEM214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037795038" evidence="1">
        <location>
            <begin position="25"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="214" mass="25058" checksum="12502E71C889D677" modified="2023-02-22" version="1">MASMQNFFTIILLATTTFIVLDLSKNDSFNKSATGKYLNKIGVGPHLQRFINTIIHSEFYRQYVLPAYNSLIRTLAPHMAFIRKETIKYGNHVSVWFKNTFPSLLQTVRVTVKMTIPKMLNFYSSKQIERKVIPAIAEHYSHFVVYTQKYWTVTYSKMQEISLITGEWINQNVFTKFPRDQLLKTFNEFIANTQKMAYNSYEYLASQIQKFIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBB9</accession>
    <name>A0A922LBB9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBB9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="49" mass="5520" checksum="99A20E14ECEFFEC6" modified="2023-02-22" version="1">MAIFCNVQQDHYNHEMGSKKKAVQQPQDSQDLFSVPFPTMIAPNDAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBV8</accession>
    <name>A0A922LBV8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_003901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBV8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000006">
        <property type="entry name" value="Expansion, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22742:SF2">
        <property type="entry name" value="EXPANSION, ISOFORM A-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="70"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9530063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="658" mass="76879" checksum="594145451CC29F7F" modified="2023-02-22" version="1">MTSTISRRQIISRSRDTGLNRQQQQQKQQPMNRFAPYEDYEEMWFSHEHLFKDHIAEVLRKWEQIDDEIWAKMIFMTRNRRIAKAYVRVPAVIIDGTDNGFDGYRVGLNGFEDPFRDPMTDQLMNNIEKGCRIGIDDNGNILIKRYSMANVYVRSYPLDYSHSCVDNNVIRMNGLLELQKRYILFDMCKFEMAMMNELKSAYPDRSRLEQQCIVIIGFVRDNPDSILDMPCYVMLINIVALDMLKSKLNPVMYRNIVPHKKRVPEFVSIFQQQQQHDNDGDNHSDCCSGDDDDDDNHYPIYGQIIESSSSYGDNYLWKNKNNHRYNERRGLLYSHENGPQSMPTLANIHHPLRYLPRLEQGQSEMSIHSMTMNNRPPKLPPRDKKKLSRQINTIKSARKSQKNHNNNNSTIRRSVEIPSPDYHHNEEISTIKSRSNRTNTKCMNENSNNGENIYGTIMLTKNNGYQTSSTKQRELNSHHNNKNWPTTTTINDRYERSMTKSMPTYCIRNNNNGRTVTGPSSFHNHHHSNSTSFNRTFIGDGPNLIMNHHPHHLDEDPYYSGLEARVTSNRLNWMMRKVLSSNYINMLTSRRQKKQNNNNNNKIPKSKSSTNESSTDSDPYVSINDVYEPIYGYGINNNNNMNSRMSNGWPTIQARIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A922LC21_DERFA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002515</name>
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    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LC21"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8370" checksum="1DC0D630AB849518" modified="2023-02-22" version="1">MEIENEKKIMPATAPPLPSQQQQQQQQFTSENENKIKKKFVEFIHNHHHRVINLNNDNSNQAPVIDFVKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDN3</accession>
    <name>A0A922LDN3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003742</name>
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    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
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            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDN3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="109" mass="11909" checksum="95188F30DEDD7A88" modified="2023-02-22" version="1">MEICISGAAAAATATVIVTEFQIHNIKRKRKIFIDDVVVVAIGFLPDVVKLLTNGRLELLAKTNSNNSSSDMAEISAESRIDKCILAKCTRYSLRDEIGVAQNAHFICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HH00</accession>
    <name>A0A922HH00_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CB1 cannabinoid receptor-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_014188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CNRIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HH00"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031718">
        <property type="term" value="F:type 1 cannabinoid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029204">
        <property type="entry name" value="CNRIP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31952">
        <property type="entry name" value="CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31952:SF1">
        <property type="entry name" value="CB1 CANNABINOID RECEPTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15043">
        <property type="entry name" value="CNRIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9493444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="181" mass="20777" checksum="0A8B7D05A540A6B4" modified="2023-02-22" version="1">MVKKLTCSIFIADLGDRSNSSSASSSHSSRTIYFKNDGTRFEPNICASTLKLSNENRYRFRIVLKSTPSSISAIRINDIPMQYQCRYDDDDECVELSFEMDARQISIAANHGRTRLIIQIDFMDFHHLDLGIQTKFYDRCDSHLTWGQPFRSLIAEAESSSSSLKFNDKNFVLTKMNFLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HHL5</accession>
    <name>A0A922HHL5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-chimaerin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CHN1</name>
        <name evidence="8" type="ORF">DERF_014251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HHL5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20806">
        <property type="entry name" value="C1_CHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10352">
        <property type="entry name" value="SH2_a2chimerin_b2chimerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000019">
        <property type="entry name" value="Chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000025">
        <property type="entry name" value="Chimaerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035840">
        <property type="entry name" value="Chimaerin_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051854">
        <property type="entry name" value="Rho-type_GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075">
        <property type="entry name" value="CHIMERIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46075:SF2">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 5A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="120"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="6">
        <location>
            <begin position="297"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="360"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9493509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="548" mass="62912" checksum="C6344862FB84D8E6" modified="2023-02-22" version="1">MIMMASNNQMHNYLREIRGISGVVMTSDSSSSSSLVCSGIKSTLDASSSSNSNPLAESYGQQPKALNRQSRVVLHPQLHQQHLKNVWKHYLYELQQRAPTPKRVVCPFVIRSRPSHYGREFHGIMSRDEAEQILLDDGKQATTDQTSHHHQDDGRYLIRESSRQKSQMTLSLRFNNQTKNFRLFYDHQGGQHYVNELKRFDTVHDLVADGLITLYVELHAADYIANLANQSRYEESPYMTLHKNRLLKTNKQTRSACKLDNVQIMPIQPQELCLQDDPCDDDDSLDRKFDVRLYEKAHNFRTHTFIGHPWCDFCGNFIWGLIGQGVRCEDCGFGAHRKCSESVPNDCCPDLRHIRRIFGIDLTTFCKASQLPRPFIVELCVAEIERRGLRVEGLYRACGSSDEIDLWKNRFETDWEHTPLAQIEDIHVVTGLLKQYLRLLPIPLITFDSYQRFVDSAKKNCQEQAVQGLRDASHHLPPAHYQTLKFLIVHLNKQGLCIRGLQPDVGEKPGFNIRSDVDIHAQHSDDVSDDELLLGIRIQGHRIDDSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HIH0</accession>
    <name>A0A922HIH0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_014532</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HIH0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9493804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="397" mass="46844" checksum="ACE33B7F32C3DD79" modified="2023-02-22" version="1">MKISRLKLLLYFLQILRIVIVFIPQSGYIQPDEFHQFTEPLAERFLRVETLKCWEFTRDQPIRSMIIPQLLIGPMFLAFHRMFSPTSYQSLSSYWILVLPRFIMVLFSFITDIVLKRLVTMINNNSDGHRSLSSSSRTKLYTSLIHSSTYLAFTYYNRTFTNTIETILMALLLLIIFESLQLKRQKYTASSTKIGSILAIGFFNRPTFVIFASVPVIFWICSFSRKQTTTTTTTKTTAKHRIWSIITKWIRNSFAILQSFLVVSLMFIVGDSIFYNRFDLMTIINDPYDMIQNLVITPWNFIQYNIRPSNLANHGLHPVYFHSLVSMPLMFTLLAVMIYMNLFHNMWKFFRRSSSRRQCLVQIINDFYYGENQFRFRCTLHLTIFRIIIIAIIDTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKC3</accession>
    <name>A0A922HKC3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_015775</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKC3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000025">
        <property type="entry name" value="Spalt-like transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF107">
        <property type="entry name" value="ZINC FINGER PROTEIN 521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="119"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="309"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="123"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9491038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="541" mass="57592" checksum="4993A9762BA960EB" modified="2023-02-22" version="1">MSKAFAASNNNSINNNNNNNNHRSSSSNIQNIGRHHSHHHHHQQQQQQQHQLHAHSTTNNRITTATTNNNNSGNYSMNMGSFNASSCYDQAVANMMSTNYGGLLSAAFGDPMRSLFGVRNLPGTNGTGNSNNGTSAATAATNNQTGSSSNSNQNSAGGSSSEHLQAIYGTKSTHHHHSHHMNSGGGANTNGGGIGQPNSAMNAHQQQQHHHAQHMQQQQSHHQTSQQHHAHQQQQHQSHHQSQQQQQQQQQQQQQQQQHQNQSDKDFFCELCCKRFSQKGNLKTHIRSVHTKEKPFTCPVCGKTFSQKGNLKTHMQRHAGTYPSQKRSTSSRRNTLANHPNNPPNPAAMVAAVNGNQHSGGGGGHHTVERVSSASLMQAAATYGPNSVLDLGLGAVAAAAVNPNNNNNNNAGGHDTRPNGSPSRSSSVTDDDGGSSSSPLSDIPSAAAAAAAAAAAAASSHHSNLLNARNHLNHSLSSQNNQRNFEIGKTTDSTTDPTMISFVNATGVNVGPSSSSVAAAALTLYSPSTTNQLLVKRRLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLY4</accession>
    <name>A0A922HLY4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="824"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="927"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="965"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1342"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1482"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1596" mass="193982" checksum="053E569D127CF9EF" modified="2023-02-22" version="1" fragment="single">MSDNRFVFTLYFITRYKYHELFLMNFIIRQFAMKKNPECRWFIIQIVLSESTILLMIVSNRSDLIYQFLLLTFIQIEYLWLDQFRKILSYNFNANKLFIKYNVFNDNNHHLNTRYRSHISHLIHNGNLISKILIKTMSKAVWLSAVFINYTTYSVYINDDDNNGEISFITLIAYNLLMFNTAYRMTVMFSQLFDAMKYLLFIIEFFCLKFKQFIMIRLYRRRLLFWLIFMKKYNEFFREISILNQTVSGVFFCSEMISKLAIIFCTLFFSKQNSMNIYNWIIVTFLLSSFIYADCLYSRVARLPQCNQIGCRKLINWLAKFQRNRQCPNRSQRLLIRNSIKLNLFAQTMSNNRLGFSCGHVFFITKFKFVELFILNFFECFKYYVFRLEYSLDDYQNQRIPWTYQTFRRAIWITLNSWINILSFLHLIVYPTNIELKTMKNFESELQFDRCDLIFPPSIFVFVMLEYFWFTLFHEILTYKFKVSQLIVKYSHFNNDHLEPEYHRYITRFSHTGNFASNTLNVVVVINEIIFYLLIIHRIYSFYLNDEISMFFMIIFILLITNSSYRIEYMAGQLFVAMKYLLFINEFFKIQLKRLVIHLRWTIKLDRFLLLSKRRSIWTRFMKKYVQLYYEVAIFNKTISGVFLDIEAISKCSIVFCIMFYSKQIHMNIHNTIIVILSLAPFIYTNGLYSRVAQFPQFNQIASQKMMQWLARSQYRRHYRHDRNRLFIRDIIKSNLFVQTMSKNRFGISCGQKKKRETMSLMILMKMIQKLWLRYKCPSPISIRTIMQQCFQSWKQYAARIEYHPYDYQNHKIPWTLKTFRRTIIITFASAVNISFLITLVIGPEMIGLPISLNDMDHILHVNECRILAIYAIFTLLILEYMWLGVFRRILRYECRVNDIFIEYSCHDNNCHYLCANIHRYFTRFILIANIFFGMIYRLLTAGISIVFILIVYGKILSYLHSQIHLLNIILFILIAIFVYIHTSYTFGQLFISMKYLLFMIEFFRLQSKQLLQDLLEIVLQRNTINHHHHHRQQRHCKRIIINEHLIWQQFYRNYVKLYDDTSKLNCSLRAVFLSIEMISKCSIIFSSIFYGQQIHWNIFNSMFVLLLMCAFHSNMAIYSRVSLIPSYNEKCWHYLCDWNARKQYYLQCHRNQLIINNNHYPLAKSFNHHTIHLNLFIQTISMNQFAVSFFQSWKKYIARMDYNLDDYYRRTIPHTFQTFLPSITIVLAATITIVYLIILVAFPATATTILPFTLNDLEKILKFQSFNLILWYSIIVLFILETVWFVAFRKILIYDCRINDIFRKYQYFHNGETFVEPKYRHYFHWFMTITNLIANSTYKSLLYILILTLLRILYWVLYIYWDNRIDFMKVFIFIIVCIAIAWHTKHSFGILFISIRHLLQYIELFRIQVKQLVIRFKSKSRIRNFWHQFHRHYLILFNEISTMNYTSREFYIKMELISKFSIIISSLFYSQQQRMSVVNTILVILLLAVFFSTIAVYLWLSLIPSYNEQFYHSTMKRYVRSFVVVDNHHQHQKHQHHRHQRHFKQLQRIRQFRDRLKISHFIQSISENLFGFTCGQIFFINKYKWIELFMFNFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN76</accession>
    <name>A0A922HN76_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphotyrosine interaction domain (PTB/PID)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">APBB2_1</name>
        <name evidence="5" type="ORF">DERF_013768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN76"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039576">
        <property type="entry name" value="APBB1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058">
        <property type="entry name" value="AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14058:SF8">
        <property type="entry name" value="PROTEIN FE65 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="3">
        <location>
            <begin position="270"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9497812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="444" mass="51062" checksum="A7546B0A6097781C" modified="2023-02-22" version="1">MMADTDQFANESITNVDKLISNQQQQQHSKNVKKSYENPNYRKLYAKLSMNTMIGTNESSSINNNHDDNAEMNPFSFGEDEDDDDDDDDDSLANEEEEDDDDDDEYEDLSSGDENVKQNLLQQQSNDSKKSQTSIDLPDGWERHEDELGSYFWHIPTGTIQRERPYLNTIDKSMIRSDSLVFLDKSAINIDYNPADSIEENPDGESKETENHDVADDDDDDDDEDEHRQQTKALINRKKIIANMQLTFPTTDDDDDDDDDDSTSIAKELSFIVHSLGWLDVDESQINSQTGSMVIKRCIYELSTRAENAARCWGPSDTQSLILKINNERISLLEPNTSTTLTVQLIREIRMWAVDDNNNFAYVVKDRKSGKPGTVKCHIFHCDDDQQQQQQQQENNCGTTQTQQQQQQTAQRLALYLKDALVRIKNHQQNRNERRPNDLLLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN98</accession>
    <name>A0A922HN98_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heat shock protein 83</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HSP83_2</name>
        <name evidence="14" type="ORF">DERF_013797</name>
        <name evidence="13" type="ORF">HUG17_0881</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN98"/>
    <dbReference type="OrthoDB" id="5426351at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="12">
        <location>
            <begin position="30"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="694"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="123"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7645343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9497842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="718" mass="82833" checksum="C503FAE9C2160C0B" modified="2023-02-22" version="1">MPEEQEIETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLGEQKDLYIRIIPNKDEKTLTIIDTGIGMTKADMINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSGYLVADKVTVHSKHNDDEQYIWESSAGGSFTIRPDTGEQLGRGTKIILHLKEDQIEYGEERRIKEIVKKHSQFIAYPIKLMVQKEREKEISDDEEETAADDDKEKDGEEKKETDEAKIEDVDEEKEKKSKKKTIKEKYNDEEELNKTKPLWMRNPDEISQEEYGEFYKSLTNDWDEHLAVKHFSVEGQLEFRALLFIPKRAPFDLFENKKQKNNIKLYVRRVFIMENCEELIPEYLNFIKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEELNDDKEQFKKFYEQFSKNIKLGIHEDTTNRKKLADLLRYHTSSSGDELCSLKDYVSRMKENQKHIYFITGESRDIVAHSAFVERVCKRGYEVIYMVDPIDEYCVQQLKEYDGKTLVSVTKEGLELPEDEAEKKKLEEDKKRFEDLCKAMKDILDKKVEKVLVSNRLVSSPCCIVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKNLEINPDHPVVEKLRQKVEIDKNDKSVKDLVNLLFETALLCSGFGLEDPQTHASRIYRMIKLGLGIDEDDTVVDDGGDVIDEPTVPDSQAQAADVSRMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNJ6</accession>
    <name>A0A922HNJ6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNJ6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="154" mass="16882" checksum="A7FB212F88CE1190" modified="2023-02-22" version="1">MKKVKQQQQQKCLRSSLKGDDDLHLDIIILPWTIFVGRSFVRSCNSISICVDPLCSSAQHKKKNRYGKHNKMDDKKNKNGIPPKNGPKPPVDTFPPGPSAIERPTANPLVNPPPCGPTLPPTATGLALAVIIVIIRSSSNNPAKKLVTICIKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNL8</accession>
    <name>A0A922HNL8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adiponectin receptor protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ADIPOR2_5</name>
        <name evidence="10" type="ORF">DERF_013934</name>
        <name evidence="9" type="ORF">HUG17_0751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNL8"/>
    <dbReference type="OrthoDB" id="6485519at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7645213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9498007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="336" mass="39314" checksum="883A81D6F32D859F" modified="2023-02-22" version="1">MADNCPSSSCSMTKESKRQNFKNDDDDEEPSGVYPCNTCPDVHILRSISEMPSWCCTHNRIIFAGYRPITLSSWQTFRSLFLIHNETGNIWTHMIGAIMFYFLFQHVCRNPPDTRSMSRIDFTLICIFFFGVFVCLFQSTMYHLFASHSMKLNKLFAKLDYCGITILIGCTFIPWIYYGFYNSPWLQTGYISFTTICTIICVLFCVYDPFGVPQYYHYRTLMFLSHGFLVFVPAFHWTIREIANNADNRNDFQSFLSLDHRAHLLILIQGIIYLSGALIYMFKLPESIYPNVALFNLWFNSHQLFHIFVVFGLILYYHSLVLIIKMRLADPKCFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP92</accession>
    <name>A0A922HP92_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP92"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="667"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="915"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="937" mass="112365" checksum="9ECDFEE35AC62CB8" modified="2023-02-22" version="1">MSLQIRHYIYNAMKHIVDQHDTRQYRISHNLEVILYLFWLIRGLFISLMYLDSEQFPLYEFDYMSEYFWKNRKIFNKFFMILIILFTLTGLLGIKTFFYSRVDTLSFQVLYDCIVYNTDQYYKSLDKDENVANKLSTRFRQYQRQFVRDHRLLSLMIPEFIMKKLITIRVWIGSWLELDRIDKKLFMNRNKMRLFPNANIKSRTDVLLFVLIIDIFNFIVHIFTAIVYIICNYLIIIDIISSELIRNSWIIKFQLFIEIILFIPTLLILLQCSMLLSCSITAPYQVFHNILNHLNQKFSTLYENLRRGKQIGLKESKELRFIYRQHNILCYYTVFADTDAWSQALYYYALVSIPINVTFMCELIFEDLTAETRFLFIFMMIMHAFTGLIPFIVLANVSKAYHAIRKNIPAMQLQLKRRKDLRLKLKFDDLYERLVDGKKIAYTFGYLGVLTYRGLFEQKTKMFLQIRHYIYNAMKHIVEQHDTRQYWLSHNAEVILYLFWLTRALFISLMYLDSEHFPLYEFDYMSEYFWKNQKIFNKFFMILIILFILTGLLGIKTFFYSRVDTLSFQVLYDCIVYNTDQYYKSLDTDKNVANKLSTRFRQYQRQFVRDHRLLSLMIPKFIMKKLIAICVWIDSWLKLDRIDKKLFINQNKMRLFPHANIKSRTHVLLFVLIIDIVNFIVHIFTAIVYIIGNYLLISDAILSDLIRNSFIIKVHMFIEVILFIPSFLILLQCSMLLSCSASAAYQVFHSTLNHLNKKFLTIYENSCHGKQIGLKESKELRFIYRQHNILCYYEIFTDKDVWSQALYYYALVSIPINVTFMCELIFEDLITETQLLFVFLMFMHAFTGLIPLIILADVSKDYHAIRKNIPAMQLQLKRRKDLRLKLKFDDLYERLVDGKKIAYTFGYLGVLTYRGLLEAFLGYIAAFFLIVGFYTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPV6</accession>
    <name>A0A922HPV6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NCBP2</name>
        <name evidence="12" type="ORF">DERF_013622</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPV6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF13">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9497650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="374" mass="43856" checksum="3B6576E36FEE44F0" modified="2023-02-22" version="1">MMNKTLLKVAANHMNGSKLQQELLKSYLRKTSNQFICLKNPKVAEKFCKKISNELDCDFNANSYLFEASPGYGILTEQLLKHSNGKIRVFEHVSKRRPHLETLCQKYGNNRMEIIDKQILDFASGNYRLLDLDREDFFRLCFGGLNNNWSFSTNHNQQPQPAFRLFTALSPFFARELLTYLIYSIVRFESFFESGPNEFYLFVPISMYKMMVSKPSRNLHLYTAFTIHMNTLFERYEINLHSSELKNGIDNIKIENRHCSIISSANFAYTNDRKFKSKEAFILIKLKPKPFINQMEADFLIDYVVFVKQSFMKRTNNAIKYYEKLFPGCTIDLIGLGISYHKTLGDLTSDEMFQIFSHVHKLPHYKNSIFKNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ41</accession>
    <name>A0A922HQ41_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 UFM1-protein ligase 1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">E3 UFM1-protein transferase 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">UFL1_2</name>
        <name evidence="11" type="ORF">DERF_013403</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">E3 UFM1-protein ligase that mediates ufmylation of target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UFL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ41"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056761">
        <property type="entry name" value="Ufl1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056580">
        <property type="entry name" value="Ufl1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23659">
        <property type="entry name" value="UFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25041">
        <property type="entry name" value="UFL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25870">
        <property type="entry name" value="WHD_UFL1_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like" evidence="9">
        <location>
            <begin position="539"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase-like C-terminal" evidence="10">
        <location>
            <begin position="664"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="399"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9497411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="784" mass="89274" checksum="7FB4317B67FF86D5" modified="2023-02-22" version="1">MAANWEEVKKLASDFQRAQQMSSVLKLSERNCVDIVKKLIEKKLINVLFTNDGKEYLTADHLKYEIEGELYAAGGRISIPDLVSILNVDYSYAEATANQIARNSGGEINIVLGQLVSRDYKDNLASEIDLHLQETGSLSIGDLSKQYDLPADFLVNLIQERLDTLIQGQFDNDARIIYTHDYIARYESKIIGIFSAITRSIALQTIINRYNISDKMLTSTLDKLFAKKRILGIVSGPTFIPDIYSKNQQEYVNSFFKHNRYLDYSTLTKLGISNPQTYLKKKFADQLCYLDTCAVDQMLSIQLETNFEDVVQNKSFVDIFDMIPSVLTSVDIDLLIKQTLEHKNYSNSIEILCDTFVTSKSFMEQTKDYFEQIKKDRAEEDLKNGVLQNYFFKSKNSATKSIDADNDGKKSTKDDHGGKKGRGKSSTGGGGGTGSGGGGATQRREVKTKAVKKKYKPGQKGQKMEQEPDDAGINELEFIPMEQIIDFLTEKLTEDVSNEFIESIAESIYEDLRKSYESYAKELFITRNAEMNKSKKSFAELQSFVNSTYSKILLFNKTNEFIGESSSQAFKDLQSRLNKHLLRTLATDIANELISFFNEELLSENISHEARTKIINKLDVEFKNDFLKLNDSLNSNEVKTFIGELDECAVKIDMMIKKIDSKKEKSILSEHQQSLLLQLNECQDSILCLHILVLLVFQMVHHHMLHASGKFVPQILQFLQKDTNDEIYQLMKQCQDYVLQFIATKDDQAKLDIKTKLNESIGHCKQLLNDFIAKKLSLRIVENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQR6</accession>
    <name>A0A922HQR6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQR6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9498100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="49" mass="5263" checksum="AAE34417A7283665" modified="2023-02-22" version="1">MTAGTTLNAMPTSELCQTFAPYVFIWCCHRQSTGHGQVATISICSSPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRT3</accession>
    <name>A0A922HRT3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRT3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="143" mass="16864" checksum="D22DBDD7E25F963B" modified="2023-02-22" version="1">MVERVHLTFWNLLRVVVADSHNDLVVHLPSVLDVYRDTIHAMLGISSFEALFNHKLNEDYLLLNKKSVELQPYCKINRHSNITKPYNTKKTVQIKKPEFAFNCFINEKWTEDFNRFDSALIKYLEDSVSMEGKLLDPLPNYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS05</accession>
    <name>A0A922HS05_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_010933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS05"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055470">
        <property type="entry name" value="DUF7042"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055471">
        <property type="entry name" value="DUF7043"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055472">
        <property type="entry name" value="DUF7044"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055473">
        <property type="entry name" value="DUF7045"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255:SF4">
        <property type="entry name" value="CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22255">
        <property type="entry name" value="LP06548P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23069">
        <property type="entry name" value="DUF7042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23070">
        <property type="entry name" value="DUF7043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23071">
        <property type="entry name" value="DUF7044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23073">
        <property type="entry name" value="DUF7045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="746"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7044" evidence="5">
        <location>
            <begin position="18"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7042" evidence="3">
        <location>
            <begin position="160"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7043" evidence="4">
        <location>
            <begin position="311"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7045" evidence="6">
        <location>
            <begin position="430"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9506191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="769" mass="87121" checksum="93E9B0A5CC6D6C18" modified="2023-02-22" version="1">MVNNRFFYYFQLITEASACYFPIEYQGTFLIQTQGLVAFAPQIDHSQTNANQSSVTYSEVMIEADAIQPWGRCHKRRGNNVILKDSTGAGQDCLRCFHLSMKTPNVISLHTDGLERCYTNEEAARATCPLDKDIGQQKRKFKEIILFRKHVPGGLQSIEHVFCPFNGRFRFSYIGNNGGSSTSQQQQMRCDFGYSEMSNCPHGNALNVKFRKCSFQTMDIHFLCLGDWPTTTTTNSNERYLALMDLREAPEANRPKYRCGLYKEDHLTGQITVSLSSDSTCTTQLSNSSVGYESLILSPLPNKRIPPMVEASKCRFPDWMQGRWQRTKVDNQQFIYKDAQNQFRTIRSRCIQRQSDLANDRFIVHSITQCGEQSFSCLWVKRRSPNIMEFRFSDKSSSIMNDKLCDERNFATNQWITEGKEKIVAQSTPCPITGDYTGEVPGASGLCAKVASDCNNPDIMFYSVSSCENRSHVYEEREYRCLGNWEEDGVLYTFTQRRDMPGHQCFAGKVYRNGDEAYIKEAGEDSCLRGEDEDPIIFGMKITKQASCPRHILPKPIIPASILPHPPSLSLPPSIQHHHQQQHHHHSASPSDVGNTQQHASGHKSQSIGIAIQSSSQPQSPINKFSYPPIIKPLMPTLPPAPPLPAVILGHHPSFKPIHVDHHNHPHHRTNNNNGDDNVYSPPPPPFWQYDSTELQNHHPSSASKTHYRPIVESGNNHLNNNNNNNRHSHREISSSSTSILATSSWTFWNIMLISTIVIQIIINPIVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS67</accession>
    <name>A0A922HS67_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein O-mannosyltransferase 1</fullName>
            <ecNumber evidence="4">2.4.1.109</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein rotated abdomen</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">POMT1</name>
        <name evidence="22" type="ORF">DERF_013713</name>
        <name evidence="21" type="ORF">HUG17_0949</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">JKM2019</strain>
            <tissue evidence="21">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Rt/POMT1 and tw/POMT2 function as a protein O-mannosyltransferase in association with each other to generate and maintain normal muscle development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with tw/POMT2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS67"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23281">
        <property type="entry name" value="beta-trefoil_MIR_POMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="20">
        <location>
            <begin position="373"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="20">
        <location>
            <begin position="445"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="20">
        <location>
            <begin position="508"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAH7645411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAH9497753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="798" mass="93047" checksum="640A0E89031B88F9" modified="2023-02-22" version="1">MAIQIKNRKKQATDNLNSNQISESSSSSPNEYEDDNGKPNEKNLKNVTTNCHENLIRQWFTKKNGIANKNTTNDLMMAKISENETEFPLAITFRINIMVLILFSIAFGFRIYELDQPRSIVFDELHYGRFVSLYLRRTFFFDSQPPLGKQLIALSAYLSGYKGEFNNFTNIGQDYDANFPIRAFRLVPALCGSLLIIIIYQFVIEIGFHHTIAFLSSLLLIFENSLLTQSRFILLDTILMFFSFLGLLSFLIGRKKLLFSKSWLFWNIISAISLTCGVCVKYIGIFTLLQVQILSFWNVFDKLSDKTMKTIHLWLLLLYKSCIFILLPIVFYCFIFYIHLSVLIKAGPHDNIMTSAFQASLEGGLASIIRGQPREIAHGSQITLRNTHGRTCWLHSHHAVYPIRYPDKRGSSHQQQVTCYSFKDVNNWWIVKRPNVDDLITHEPRDNIKNGDIIQLVHGLSGRTLNSHDIAAPMSPYNQEVSCYIDYNISMPAQNLWRVKLLNSDDTSDYWHAINSRVQLIHINSSQALKLSGTQLPAWGHHQHEIVTDKQINHPNTIWNVEEHRYTKNSDGKEIERELGMAEFVPLSPTYLSFWDKMFELQYKMLINTENIQNHIYSTDSPLDWPFLTKGIAYWLSPKSNAQIYLIGNIFLWYFGIFAMVTYWSLFLFYQLRRKRLINDISEDNWEQFLLIGRIIAIGYLIHFLPYFFSEQTLFLHHYLPALMFKIMLIPMIIGHLNQCVPNRIIFSIFITIAIIIAASYTFVQFLPFSYGLKEFSASEIMKLKWKKTWHFLIHKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSH8</accession>
    <name>A0A922HSH8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSH8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037042994" description="Chitin-binding type-2 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13598" checksum="1D45E41D608CC571" modified="2023-02-22" version="1">MKFYRITISIILTIMIMIEHQFLGGGCRIFHRCHTAHNAGNRIQVLHYSFFCSDRLVFDQSTHTCRRRADAIPCETSPLFFDLNDRIGSDGPFLTHGDIDREKAVRPEYRRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTX3</accession>
    <name>A0A922HTX3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase rnf13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RNF13</name>
        <name evidence="13" type="ORF">DERF_010703</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTX3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000429">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037640925" evidence="11">
        <location>
            <begin position="22"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="236"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="355"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="497"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9505940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="538" mass="60355" checksum="5D83EBB47F0B929F" modified="2023-02-22" version="1">MYRRFINTVFILAQIRSFIVADIAVLDSQNKSVELFIDYKITYTPPISEDGIYGALTFASPSDACAPISPPPSHPNLTINWFVLAYRSSSLHSRCSNREKIQHAVQAGYKAMILYSPMDFYQTSVIYSTTFEHLNISIPAVLVSHEDGQTLRSNFLYESGFRLYITSEIPPNFSYYLIPFAIIIGAGILIIISYVVFQLMMCIMERRKAQRHRLSRKDLKKVTLQKFEKGIFYETCAICLDDYIEGEKIRILPCNHAYHMKCIDPWLTKNRRVCPVCKAKVTLPGMEEYSDSDSDNDNQRSNRYHQPNERTQLLPSSSSSNTPHPTTSVAGVPTTSTSVNLEEIIRSIISGRASRTTSMITTPGSRRNRYTNIPDLLDDSTIQPGPSTSAPIISADISSQQSGQQQISRNLSSSRVNSARRNRRRNQRNSAQQQQQQPQSQLQSQLSSSSEHNQTVVPSVQIVIADLHTTTSDNIDQQHQQSSSVLIAPLQLSINCDSSDMDVQRPLTPDDENGSQKHGSQLPPPPPQQSSSSMNEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU33</accession>
    <name>A0A922HU33_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU33"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="201" mass="23873" checksum="3CD8A718C39BF0EC" modified="2023-02-22" version="1">MTSDKISNKNEDHHKIIVEDEWQKLVQSLNQSADYDELNKLYDRCSNLINEHLHLRDELNKSFDDNIQTALRESNLEFNDDDPIPTLPQLIQNQEQTYDRYQQSKQTLNDITHEQLKTDEQLKSLKTEVKTLRKKRDQLKQTIDEIDNNIRVMNSYLQIHNESIACFFSHINGHLQDCLIENEENSTKEDFCRLSRIILND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUA4</accession>
    <name>A0A922HUA4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC protein, sub ABCG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">wht-4_28</name>
        <name evidence="11" type="ORF">DERF_012856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6489438at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1020"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1134"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1161"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1192"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1265"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="37"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="712"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9502057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1335" mass="153749" checksum="7F23FEFE21826920" modified="2023-02-22" version="1">MASLKRIKFSATNLEFSDGYYYDDHDCCNVAMAWKNLRYEVNNRFIGGSGRKVILRRMNGHLEYNSLNGFLGPSGAGKSTLLNCLNGTYRSGLSADSEIYINRQENDKPRIRYIQQHVHETIIGSMTVRQVLYYAFRFNNSYKHGGSEMDKQMTNVLDQLLLDHKVLDRRFDLCSGGEQKRIALAQELMSLKAPKFLFVDEPTTGLDSHAALLMVRCLRKLADNPQNRMTILASIHSPNSDILKLFDKLYILAKGGVCIYSGLPTLLQQNLHEHIGLVHDRSKPPIEEYLAIACKGTGDENVRRLVEATWSQQQTELKQMIPQMKFLPQGVIVDHKLFSAGDFLLQITRMCQLTFIKQINSRIITIFLLSLVCFIHSNLFDQDIIKPDTCVSAVDFTKPENNQTCQDELDDNNRIEFYAFYQSLILMLIGYSLSGISSLTFSSLIKIFKNEHRNGWYSVGVSYWSVIIVRLIDFTILALHVTIMMYFLIDHTHVDDGQFNWYRFGNFFLFIWMFIFYIQSLGQLFSIIFTNFLDIAVSLSFVAYASLDFNNGYMFPDNYIVMTASKILNDFIGSKYIRNGLLYSFYGIDRCDTDEISSVLIDHDINPNTVYRNLYQILINSIALRMLTLFIMMSKFQSWSFSSSKRLSQRLNPKDFLRIDYENSTDLKSFKTSIETNERKKSREEIEFEKFSKDKIIIAWRSLSLFNSSSIFELRSALKLEQPKYILRNLNGQFRFGTLNALMGTSGAGKTSFLKVLNGRDKTRLSTETEFYVSKFTPLRTCYITQEISCHLTSGLTALQSLIYASKLKNLGENIDHKHMAMAMLEELDIADTANTLVNKCSGGQRKRLALALELMSLRMPNFICIDEPTSGLDSSSAEVIITCLRKMSHKHNITIVAAIHQPNTEMLMLFDQVYILARGGVCIFSGPPSQITDHLQQVCSDDRGYKDEKFAVEEMMKFSCLNHLNPQIRILAQSSNVLIRDNHFENQLMTDTQFVLDGLPINRTRFSLHSVIILIERQFYYYIGSSITQFLLFFFLCFSFVNGLILKSLINPSMVFRSGCMSLDEDLSNCNRSKDERMELLINYNYINHLQDSFGLISCFFFAAMFVSQRNLFKIEHRNGWYSSGAFYLTKAVSEMIIALPVIVMYPIIIDIYYPIRTYVWYNMIMITILPMIAFQGASYTLSILFGHNPLMLYISIPALLLLSIICTVTPYALSHFAFKLITTFNLFRYQIEAILFLVFGFNRCGHREVQVLLYRLGLQHDDYFYHCIVMTAINALLYQTIALSLFCIIHNPFENRRKRIERIRYLNQRQLPSKVMIPGLGCSNDFTIKTISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUL5</accession>
    <name>A0A922HUL5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="31 32">Activin receptor type-1C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="32" type="primary">ACVR1C_1</name>
        <name evidence="32" type="ORF">DERF_012661</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="32">Derf</strain>
            <tissue evidence="32">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="32" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="32">Derf</strain>
            <tissue evidence="32">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18673"/>
            <dbReference type="Rhea" id="RHEA-COMP:11022"/>
            <dbReference type="Rhea" id="RHEA-COMP:11023"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25 34">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUL5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004396">
        <property type="term" value="F:hexokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd24019">
        <property type="entry name" value="ASKHA_NBD_HK_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14143">
        <property type="entry name" value="STKc_TGFbR1_ACVR1b_ACVR1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23598">
        <property type="entry name" value="TFP_LU_ECD_Babo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000805">
        <property type="entry name" value="Hexokinase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000045">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000023">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF71">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20 32" id="KW-0675">Receptor</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 28" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="655"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="30">
        <location>
            <begin position="709"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="736"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="27">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="763"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="KAH9501850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="KAH9501851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1034" mass="118093" checksum="4544F725713B550F" modified="2023-02-22" version="1">MMMASSNTYDDDDNQCHHQHPNQHRQYHRSSCPSSSSLLLNKKIFIYNTILILIICTKTIVVDKECNNNNNPAFIERVDSLTKHFQLSHEDFEKISGLLSKEFDRGLRSTKDSIVKMYLTYVRSLPNKEEHGRYLALDLGGTNIRVLLLKFHGPGSDTSLVKQQQQQQQQEQSEKIEIIDSLCQPLPTELFYGTGQQLFDFIAELIVSFALRNKLAGVRIALGFTFSFPVVQHGLAEATLVTWTKSFVCSGVVGFDVVRLLKASLKRKMHHSIPYIDVVAIINDTTGTLIFGALQDKNCAIGLIVGTGSNACYVEQLHNIEKWPFNYSDPKQVVINCECGAFGDNHVIDWALTRWDRGLNYESLNLNKQIHEKLISGMYLPEILRRCLLTLIELGILFDGRPPLELFRPYSIKTKYMSQIDQDDGNNNDFLHTRKAMQNIFGTENPRFKNGFQDSDVKIIHMINQRITRRSANFVATALWTLMCRINREDISIAYDGSLICLHPHYRQWVENKLNEFIAKSGHIKRFNLIHANDGSLYGAAIVAAICYRLLCHCDICEKNNNTCETDGVCAATLYKESGKIRTSYRCYDKRDLLPPENPVHCQYSKRLQRNVDIHCCVDRDFCNKNFHFNPQLFNNNDDTDSLDSVASNYFTKNLPIIISSIAILFCLIFILIVIIIYRRKTQVKTKKKHFINDVEGSVASCDPLIPGQLLKDLLDHTSSGSGLPLLVQRSIARQIQLLEIIGKGRFGEVWRGKWRGEWVAVKIFSSRDEQSWFREVEIYQTVMLRNDNILGFIAADNKDNGTWTQLWLITDYHERGSLFDFLSKNTVDIAGMLKMASSIANGLAHLHMEILGTQGKPAIAHRDLKSKNILVKMNGTCAIADLGLAVRYDSSTNSVDIPPNPRVGTKRYLAPEVLDESININHFDSFKRADIYSFGLCIWEIARRCNVGGIHDEYQLPYYDVVPFDPTIDDMKKIVCIERQRPQIPNRWQSCEALRVMSKIMKECWYHNAAARLTALRIKKTIANLEAQEDLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVE3</accession>
    <name>A0A922HVE3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation protein SPT3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SUPT3H</name>
        <name evidence="7" type="ORF">DERF_009639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVE3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9511169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="569" mass="64851" checksum="36B6478372377B42" modified="2023-02-22" version="1">MAKNITSNAKESSANTSIRTNSDQAFASSSKQNVKRTVAKRFVLNSFSDTTSDQLNSKCQQNLRTSKSTWPTRSSSLSNNGNKITSYLEEIRRMMHAFGDVRQPLIESASMIQSIVRHQMTMLLLEAQHVAQMSHSESLSTPPPRTHISVEDFIFLLKHDRHRLAKLIRYLKFKDMKLKVLSSSLVDSKEKSAQKQSKISKSQLECLYNDIKNESQAYDSDEWPRLPNGQANVCDGESKSSSSFETSSSTLINNQPNASTKRLKSCQEILRSVIQTPQNRCEMERLLYHHPDVAIDLIDDYTMARNRRLNKFTEQMSVKEYLYYQSCRSVTFFGSSTGSQIITTSMFQKFQDWILGSFDEIDRLELKPNSLGWEVVQYFAHETVAILVELALIVRNDQNRHVSRPGIDAGRPLYPTTIESQAMSTKRFRRESVSIGTDSAAKVFKCDPMMNQINSGHTTSNNNANGWQRSNSNQQFMVDILRRTSEKVMAFQTASTSTNDTAANIKSIKNVQSSTHPRISNIFGAITPEQILEAMRRFESGSNVFNRFQRCHGWLFAQNRRNRILCLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVK5</accession>
    <name>A0A922HVK5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Papilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DERF_009728</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has antibacterial activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd22639">
        <property type="entry name" value="Kunitz_papilin_lacunin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000017">
        <property type="entry name" value="papilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050098">
        <property type="entry name" value="TFPI/VKTCI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083:SF374">
        <property type="entry name" value="BPTI_KUNITZ INHIBITOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10083">
        <property type="entry name" value="KUNITZ-TYPE PROTEASE INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="272"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="331"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="391"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="450"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="546"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="612"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="711"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="768"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="867"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="14">
        <location>
            <begin position="942"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="17">
        <location>
            <begin position="1114"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="1383"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="1482"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="1639"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="16">
        <location>
            <begin position="1743"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="825"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1219"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1219"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1246"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1285"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1351"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1375"/>
            <end position="1389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9511259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1804" mass="205522" checksum="47188242A68C105C" modified="2023-02-22" version="1">MTTINAEIEQTTLSTDTIPIAGLSFGNCSDGDDPSMCAISTTSANLVTDCSRSKFGCCPDGWNEAQGPNGEGCEEGSGDISTFLASTINTVMNIFITTEVPVTEEDIDCSLTEFGCCPNGKKKATGIRYYGCTCHDYPFGCCQDGYTPASGENHEGCLCERMLYGCCADGNTPAKGPDRQGCDCTSSPYGCCSDMFTFAQGPNYQGCPCDTLTYGCCPGSQIPARGPDFAGCSCADTPFGCCADGITVAYGRKFEGCPSGLPLDMKLNSEVCKLPKESGPCSNFSVQWFFDNESGRCNRFWYGGCQGNGNRFSSQEQCERSCVKPEGSERCLLPKIPGPCNSSSEAYYYDEETKRCERFLYGGCLGNTNRFETMEQCVQTCIYQETALDQCDQPPQPGPCRGSYKRWYYRREEGRCRDFSYGGCHGNLNNFQTEDECQSACASRTAFEICMLGKAEGSCLGLFPRWFFDYRTGQCQEFTYSGCGGNKNRFIDRISCEQLCNQTVPDYFYPTTHQRQSYDQQPSYPYSERDNEIVPVVPPSSYESVCALPYAQGNCRDAIIQWYFDVNTRRCQRFYYSGCGGNDNRFNDQIQCEQKCLAYASQITPMMQHDPCLEPKDIGDIQCQDYRHRWHYDVEDRRCHRFYYYGCGGNRNNFETEEECTARCVIPRERGSQQQQQQQVIRYDGQRLPPTHSDAEMHGITSIEEFHPENCFKQFDSGPCEKNHIQWHYDSRDGVCKEFIYGGCEGNENRFHSQQECQTKCWNSQDICKLSQIRGSCTGNFTQYYYDHQNNECYEFQFSGCYGNANRFNSKETCEQQCRNEHPIPSGVSQQQISQSTPVDQHRSQQQQQQQIPDVSTSPNKTHLDRCHQPMVKGPCRAYFPRYYYSAEENRCQMFIYGGCDGNENRFDREEDCEKACKRTPDSVREDEEEPREGIDQPEVICFLKMEPGSCHETRARWWYDPNSHTCFPFVYSGCRGNKNRFENFDSCIRFCSGVSQRQQQQSQYPSHQFIYTSPASPTIPEQQQSYPYVPHTSRPLPSTHEQSAVHPGCEPMECQEDNCILGIDYYHDQRGCPVCRCVNPCNDIRCPEEMSCAVELFRDEITGKIRANAECRLRVKPGECPRNIHIVPESEREQSIECYDQCRSDADCRASDKCCNNGCADICVAIEGYYTYQESSKMPLSSSSSSEHQYNQSTYYYSPTHDVSQQQQQSSYYNYSVVNQQQQQQQQTNGDHHRQPPYAEGSTYNEHRQEYGHDQNGSRDGGIVTQSNGHPDQVVHTGEQHVYHTTNGNHNDDNGGQNQSTQQQQPSYPYDQNQLQPGQQQQQQPIDPNQDQQSIYSYNYPYSHPDQRQQEQQYQYNQRQNVDNNGNYPDRQQHSGNGQSPPQDSQHYPGSIVVRSGQEEAILDCPSSKDSMNLETNNQSTSSVIWIKDGQQIDQSLDRYDLLSNGSLRILNIEPNDRGIYYCLANPKTGYQMVPLEVNEPAKILPEGPKRVIAQVGMPIYLHCHAIGSPEPKVTWWRGDQMLPINDRKYQQWPNHTLIIQRVEEKDSGYYTCHATNGIEPEEGERKDIELLLDIASNKRDELEIVPYDPSLFHHQNNKDQHIIGDQQSNAQNTNEIDLANANGNTIISNTVAIHEDPITTEIDFWPKDYRVGSLLHLDCIVRNQRTNQIIPSANVVWYVNSDIPLLVDQTNHHHYMLMANNSLLVYHLTRGDSGEYRCRASTGPKSDSYSSVHLQVENIHIPADCQDSPVFANCAMIVQNNYCRNPHFHKFCCRSCYIAEHGRQKSQHYQQHESSSNEINQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVW1</accession>
    <name>A0A922HVW1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">P4HA2</name>
        <name evidence="15" type="ORF">DERF_011680</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the P4HA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVW1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000001">
        <property type="entry name" value="Prolyl 4-hydroxylase subunit alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013547">
        <property type="entry name" value="P4H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059068">
        <property type="entry name" value="TPR_P4H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF244">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08336">
        <property type="entry name" value="P4Ha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23558">
        <property type="entry name" value="TPR_P4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0847">Vitamin C</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="465"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9506975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="596" mass="69347" checksum="A9D382097FEA1DB5" modified="2023-02-22" version="1">MATMGMGRIFFTSSTIITIIMMMMIIQQSHQEYFTALVHLEKLLKTEQHIVESLNNYLDNEEKRLASLRQLAHHYNHLNMVANQDVQTYLSNPVNAYLLVKRLTTDWNLVEYLIDADRKDLIHLLTENETFPSAEDLSGAAEALLRLQDTYKLDTTTLADGVIPAIKNQHPIDYYDDLNNKHKIIDENDVNSAIDSATKLTMPLTADDCYELGRQAYHQKDYHHTVLWMKEALRRLNDEYNESPSMANKLRYDRVNILEHLAFASYQLGSLQEAYEYTVDLLDINPNHERARGNLEFFNNELNISNRLRRIRKGDTNDPDVPDENSISESTWPLEENERDIYEALCRGENRLHESIRSKLKCYYLDTSKLLDKFVRLWRIKVEEAYKRPNIVLFIDFMSDDEIEVVKRLAEPMLKRATVQNYFTGKLETAKYRISKSAWLTNRDHEIVYRISRRIEAITGLEMDTAEELQVVNYGIGGHYEPHYDFARREEPRAFDSLGTGNRIATWLNYMSNVQAGGATVFPHLGVQLWPRKNAAAFWYNLYKSGDGDLLTRHAACPVLVGSKWVSNKWIHEVGQEFRKPCGLWQNELNIVQHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW43</accession>
    <name>A0A922HW43_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RPA1_2</name>
        <name evidence="16" type="ORF">DERF_010010</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW43"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="16" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="12">
        <location>
            <begin position="216"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="15">
        <location>
            <begin position="308"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="14">
        <location>
            <begin position="462"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9511559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="618" mass="69509" checksum="27E7149461ABF7F5" modified="2023-02-22" version="1">MDNRIKLSDGSLDLILEQRNLNLRPIVQVLGAKVLANNRLRVVVFDGRTLCQHCIMIAEEMENLFNQGQLDKFTIIRLEQYSVSSIPKKENTPVILVQKVEIIKNGNDVGKKLDPDESIDLVDTAASAGTSGNTSAAAVADSVMTDSASSSTIIRNTMNQLTSSAQKKPPMKATAGDIEIRTENVCPISVLTPFYNSWMIRALCIHKGAHRTYSNQRGQGRLFSFDLCDDTGEIRVTCFNDECDRFYNLIQKDRCYYVGRGMIKTANKKFSTVNNDYEITLTQNSFVKLCEDAQIEAPKLRYKFIPLATIADKDANSAVDVIGVIRSVGEIETLTSKKTSKDLIKREIIIVDKSLAEARLTLWGEQAQMFNGQPDQILALKGASIGDFKGKTLSARDSTDISIDPDLPEKNLLEAWHCSLSGNENFNQLSKTSDSPAICQMNHFIAQIIPKKLKLDETFNFYTTATVHAFNRIHNQLYKACGYNKCQKKVTDTDGTGAYHCSKCERTSAIFEWRLMISVLLGDSSGSFWATLFQDQAEKLLGKSVAELVQLYEEDQNLYNAIVDELCFKQFNFRIYSRLEQYNGENRIRHTVGQIYFLKPKATMTKLLRSIEIVSRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWW9</accession>
    <name>A0A922HWW9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWW9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036949847" evidence="1">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="175" mass="18511" checksum="13D20FD434DF49A4" modified="2023-02-22" version="1">MKFSLCLFIIVSALMEFVLSAPNPLLIRQSLLDPATAMAAFTPTINSAQSFPTSLFSLYKNGLFGLNFPLISLITAGTAAAPVFSLPPPLPLTTTTTTAAEATTLPVDPTLLPEALSAVGSLIESLTGNISPVDPSTPATSPAADQSTTGELPDFNFLQILNNLLQLYKTFQNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX22</accession>
    <name>A0A922HX22_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bursicon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bursicon subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_006873</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of burs and pburs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX22"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038098">
        <property type="term" value="P:sequestering of BMP from receptor via BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283:SF7">
        <property type="entry name" value="BURSICON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03045">
        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037966242" description="Bursicon" evidence="10">
        <location>
            <begin position="26"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="11">
        <location>
            <begin position="61"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="75"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9516111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="197" mass="22620" checksum="4F02D8FBB64C551D" modified="2023-02-22" version="1">MFRKGKSIWFDRWLLLQLLFVTNLPEKIITGSESSEFIDSNIMVNDGQSIDKHEQTRMAECHLRPVIHILQRAGCIPKPIPSFACYGTCNSYVQVSDSKFWRLERSCNCCQEIGEREASVMLHCPGQTPQYRRVTTRAPVECLCRPCSAVDEQQVKPLEMFLHNHQFNSNLPSALNVNENESSGQRINRRINLHARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX35</accession>
    <name>A0A922HX35_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX35"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="7307" checksum="4B02CEA66920D077" modified="2023-02-22" version="1">MKNIYRQESLQENGEDKEKDKILMDDVDKKKKRKTKDFGIAKLTRQKSERKRIQNIQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX89</accession>
    <name>A0A922HX89_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX89"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="133" mass="14862" checksum="6E931F0C683DE60D" modified="2023-02-22" version="1">MDNSPGWARIPLRCASYDEPTVYWPWTRRVEISLVQLTLILGSIKRSFCDDSDRIDIVARLVMTASQTSRAMLVTVWRCPGGVNSEPNLTSYARDGLAGGPVGVNFEPNLTSYARDVWLMLTINKGYGVDMFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXB3</accession>
    <name>A0A922HXB3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Long-chain-fatty-acid--CoA ligase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ACSL4_9</name>
        <name evidence="5" type="ORF">DERF_009623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXB3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9511153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="138" mass="16147" checksum="917391C34B6E05A6" modified="2023-02-22" version="1">MYLFQQEKKLIETGLRSSRYVENICICTEMFSNDLVALITPNRKIVKELAKSLNKSQLSHPERCQDEEIITIVHASIKETGQRAGLKSKEIPTRINLCSEEWTPDNNLLTAAFKLKRKNVYQYYEKEIRQMFNSMTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXN4</accession>
    <name>A0A922HXN4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neuronal acetylcholine receptor subunit alpha-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CHRNA7_3</name>
        <name evidence="3" type="ORF">DERF_011692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXN4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="191"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="267" mass="30796" checksum="FA7C18E452CE0653" modified="2023-02-22" version="1">MNNDNDHDHDDGVNQKVRLDKMIILLAKSDSSDNNNNNDEYSLEIERKFKRSICTYFIQPIQFDFINIAELGELLSHPNQWSGIILTSKRCIDALMMSMEPSNNRHLLKVVQFFTVGTATRTYLLDKLSIDSKSPSGVDNLYDHIQHYLHDNESSILLRYIAFGRQTAQRIESKNMNETNTKIVVDEKRPEHKIMLEKWLNKNFRIKLSDNRIIVGIFLCTDCHQNIILGSSLEYLNDDDEDPRVLGLAMVPGKHIMSICVDEIIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXQ1</accession>
    <name>A0A922HXQ1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXQ1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="180" mass="20550" checksum="AAF5EFC73EC64949" modified="2023-02-22" version="1">MWNICRAQCPASIVQQSSSIFGISTVDENNKTTTTTTSDTNRQQQQQSTNNNESSLWSKKFSISRHLADSFHTLNLVSSTPIDDQLKTISSNNHRYSRFDDNSTINHTPLSIVNESWNDNNTKSIQIIDEQPNTNFFLWKISKNQNEKDQFFSSSAYGSSMNILILDRLINQLNVTIDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HY86</accession>
    <name>A0A922HY86_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HY86"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="102" mass="11491" checksum="E716A27CAA0F5803" modified="2023-02-22" version="1">MAALFAQQNLAPFSKSKIANLFMRALSNNDHKSKNTKDQISLTILANLKPHCHRPETMLERCDLIASISTKKWLMKLNGNHHHQQQSKQSSCKLCTCKSSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYH3</accession>
    <name>A0A922HYH3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYH3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="344" mass="40016" checksum="04CD77192C295650" modified="2023-02-22" version="1">MASFVDDNGLLRFKRRIENCQLSFNEKFPIILIDKTIVRDMLKEIHINLFHGGIFRTIEEIKKNFYIPKLYFLVKNLIAHCQKCQRFKEKAYGFESPPLPKARMLIPKRAFCNIGIDLFINREMKEMKIFSMIFVCANSRAVHLDVVQNKGIESLGISENFGRLGNYLTELKNFGSKNGITPRIGDLALKNDQRRQDWPIVEILELNKTGKTAKILDISNGKLIVVQFPLAYSNIGQHKCLDIVFCRFYWPKWRNDVKQWIRKCVCNVKKDNDPHPANQPMSATDIVNLNPFEKVAIDIMTLSSSESGNRYIFVPVVRLNYIFLNCDLIYRYFGICCCNFPHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ16</accession>
    <name>A0A922HZ16_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_010464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ16"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9512053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="363" mass="41742" checksum="EB2139A8F0507066" modified="2023-02-22" version="1">MIIISFHFILCVLNIWKKRRLPCMHLFHEKCIIQWFENSVSVNFLFSCPICRLTIHWRDQMSKKWSIPEHLLELEKPGTIQRITNDSNNDDDTANNNNNNNRNIKRRRNYRTTVNRNLRNDTDSNMIIVATTSTTTTSTTTTANMMVNSSPVSSRTRLQLRLRRHRQLLARTTGQSPSVILNPYHLVLTPTLESQHLKTLSLPRQSSVQIQQNNPLKVTTSKTVKRHSKSFINTVVDEIPVVNPAFNDGTIMPTAISDYDDPLRLHHLPQQNPHPDLVEIRTNQKHSPSTTTTTTRPLNVANDNDNNQLLSQTIITNNRSIPSFHLTKNVHSTLSKLSDPIEFCHLSSTTTTTHHHQLKQNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZI3</accession>
    <name>A0A922HZI3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fizzy-related protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cdh1/Hct1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FZR1</name>
        <name evidence="13" type="ORF">DERF_010532</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZI3"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="12">
        <location>
            <begin position="256"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="516"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9512134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="570" mass="63100" checksum="D3CAD5C66795A26F" modified="2023-02-22" version="1">MDNIVKSPTTTSSSSSSQSKFDCDPYIISTTISPSSSSSSTLKTDTMRSVFTPPSILYSPPLKSPAQYYRSCTTPECSDRFIPIREPHNWNLRYNMIKETTRSSMMRHKPKDSSSSSSSSPSATINGTTNMNTTPGNVGGINGSGSNVGGSGGGNNNNGSSSQSDMFRNGLAYQCLLKNELLGAEIEDINEYKQIEEHKILTPLMNRNVFRFRTREIRSEPTSPYSLSPISPKSQKMLRSPRKTARKISKMPFKILDAPELQDDFYLNLVDWSSTNILSVGLGYSVYLWSACTSQVTRLCDFSSTANSITSVSWSERGHLVAVGTQRGFVQIWDVATLKCIKQFDGHSSRVGCLAWNGDSLSSGSRDRYIYQRDIRSASLIPERKLLSHRQEVCGLKWSPDNQLLASGGNDNRIFIWNQTSNQPVQTYTEHLAAVKAIAWSPHHHGLLASGGGTSDRHIRFWNTLTGQPIQCVDTGSQVCNLAWSKHASELVSTHGYSQNQILVWKYPSLVQVAKLTGHTCRVLYLAMSPDGESIVTGAGDETLRFWNVFSKARSQKETKSALDLFSTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZS9</accession>
    <name>A0A922HZS9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transcription factor GATA-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GATA4_6</name>
        <name evidence="15" type="ORF">DERF_009744</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZS9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000001">
        <property type="entry name" value="GATA transcription factor (GATAd)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000032">
        <property type="entry name" value="Transcription factor GATA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF337">
        <property type="entry name" value="GATA-BINDING FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037918930" evidence="13">
        <location>
            <begin position="17"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="14">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="14">
        <location>
            <begin position="86"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="193"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="225"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9511276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="384" mass="40669" checksum="7E64397B256BD251" modified="2023-02-22" version="1">MVVIFVVGNMPGGLAAAAAAAAAGQAAYAAHFSEGRECVNCGAISTPLWRRDGTGHYLCNACGLYHKMNGARRPLIKPQRRLAASRRLGLCCSNCGTTTTTLWRRNNEGEPVCNACGLYYKLHNVNRPLAMRKEGIQTRKRKPKQNSASSAALSSLGLTGATFGLGGGSSSALGSLASGVVANNNGSNNNCIGSTTTTSMQNGGGLQSHHHHHHNHNHNSTGVFHLNHNNSNNHHQQQHHQSGQQQLLQHQLGNANSSSNNSSTSPLNSNSGNSNSKLGSYHHHNNHHLNHLNHHHQQQPQQHHLNSSVGSSSSSSSSSGYSSSNHHHHNHHLSGSSSSSHHNQQQQQQHHHHHHQQAAAAAAAAAAAVAAAMADSANSVKLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0I1</accession>
    <name>A0A922I0I1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0I1"/>
    <dbReference type="OrthoDB" id="6516193at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9518124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="212" mass="23600" checksum="32FE689819CB05E0" modified="2023-02-22" version="1">MDYNDQRRQDKSWNDPPMFSVEQINQAANTAPTSKRYRYPQPVQPAVNQPTYPNYPQGAVNSYGNYNNNASMAPAYQQPQQYPSYGNTSNAYGSSIQQPAMPQNYNYPSQPMNQYNPLTYTSQPVGVQSNQVIPSNDNTGYPPSSTTSMPSPYGTVTESNLVQPPSTIANNATQPVGFMNMNSVPIASMNQSAPAPGFNYNQSQQQYPYRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0V5</accession>
    <name>A0A922I0V5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dual oxidase maturation factor 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_006766</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DUOXA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0V5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018469">
        <property type="entry name" value="Dual_oxidase_maturation_fac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158">
        <property type="entry name" value="DUAL OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158:SF10">
        <property type="entry name" value="LD27791P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10204">
        <property type="entry name" value="DuoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="535"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="698"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9516001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="83190" checksum="04786A849E400212" modified="2023-02-22" version="1">MSSSSPDLVNIGASWFDAFQDNGGPVLYSSMNRTAAIEDIRNILIYISFTTFFVAFLIIFPGIRKERVSTFICVTTSLFIGAVILISNCGSNWHVAKGSIAGPYRAFSKEKIYANVGVYIGLDSVNITLKALPIHQQHEEINYNERFYWIGANQMKHEFQRALAKGLPFPILTISEYLSQDGEGFNWGRHYRLAGYYTSISLWLAFASWILMNILLCAVPRYGAYTMQLTGLLMLLSNLLYVMMIPSKPLRIPFEGSTLIFTYGWCFWLVFAAGLTACFIGATVSIVDILFPNKFSTILEVDYDTPYRYFVGNDIHIIGSLPPPLNAYYYHHQHQSSLSTASHQSSSHHLYQKKKSSTNMIRHYSASKTASLTTNTSSCCAGSTTRLTAHHQSIIKTKSDASTCTRDDVDDLIMMMANETQENHDETITATQCMTDSDSSSKQTFITKVEIESNANDDNNNNTVIVSNYSKDSVQRTNQLNQNDKIFNNNNSNNDHNDDGDKQFAFENRAYQIDDDDDFKNDNNNCLLMDENQTTVQQKQMKEKPSKELLMISTTPSPLMKSTSSSSPSSSASSISTDIDDDDDDDVDNDDENESDVSTTMIDGKRAISLSNFGKYTEQREKREGLFNRSSMIGPTFGHPLASAGFRAVKSGFITRTQQQRKLETNDSKSMKKTMDNNRIKSSSITSPSSSVQEKDTTTTNLIYNNNNNKNTTSGGSSNGYHSTSSLSSSSTNAVRVDLSSSAAMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1D2</accession>
    <name>A0A922I1D2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1D2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9518331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="87" mass="10516" checksum="B4C3AE0741E71682" modified="2023-02-22" version="1">MYFICINSNTDIRKKNSNHHLYLHLIFCITTRPLFNHHHHYYYRSYCLIKTDDCSCLLLFVHWLILSSFVLGWLPWIIIDLVVNVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1F5</accession>
    <name>A0A922I1F5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1F5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="559" mass="62349" checksum="822B5B070DA9D1D7" modified="2023-02-22" version="1">MLFWNTLGAFWQYIRQQQYNLPTTTTTNVRQPFMSNVVVVDDDDDDDVDVDVDNINKNGNRIDESITESSTTDDSFIFDQHSHSHHHHLHRNRNKNQQIFTNDSKIANKNKIHVIDEHEQQQQQQQSSTSASLEKSENIFLNRLFNSITNSIGMINMNKHLNSVQNFMDRKMTMMTTTMTTSTTTTTTTTEFVTTSTIHTMTAKSNNNKSKMMSNISCDNQNQQQQQQLQQTSSIDDDKSLNSQCDHHEHQRHIPYHMLDNNDDDDNNQNNHPNNNNNHHHHCCDKYHPIDQSSIISEPFCPFIIMRESPSNATTVSTNSLLTQTSSNYTQSPYQSSIEFDLNSDCISDFGGYTGHPHIRHASSGTLLVARPTSNTTTTTNTTATTKSKQQFFNKISSRSGGNTTPNRNLYYSRHRHSSSAVIMNHCSSSISGQISSSNSIYGCGGGSSYAGGGGGGGGGSIGIPITRRHRSSYPSYSIRNSISGIPLRIGPRLYPGRSSQSFDVDESGQTNAGNVNASGLTLQNLPVRRESFLYRSDSEYEISPKSASRHSSIGSGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1H9</accession>
    <name>A0A922I1H9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_010516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1H9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF25">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9512116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="337" mass="39550" checksum="56EA37E583979069" modified="2023-02-22" version="1" fragment="single">DQITKCKKSYFCDSCNQSFHSAWNLKRHNQRKHQENNQPPLHKENIETSKRFECCLCGEKYAGSLSTHLKSSHGIDIQTKNLKFENFQMFKSFLEKTEEETYSNYSTRRIVRDSNHQVTYANYICSRRGSMPANRLERKRASKSNKTIKIGNICPSQISLTRNKNGTYTAKWTTTHVGHELDVKFCRLPKKHKELIEHYLKIGLPSSVIKKKMSNLLGNFSDEIAMERMVTAQDIKNIKKQLNMMNDHIVEKHTESCEMITEFEDETNPMDILDPTMSISNEDDTMKLANIENVHNGNDQMNLANNRQILQPQRMFRKKFWLFGKYLLKKQKELKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I272</accession>
    <name>A0A922I272_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I272"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9518104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="509" mass="58432" checksum="25C668748DFF8714" modified="2023-02-22" version="1">MVLLYFAITMAMIISVVIWLFSIQYCQTFNSTSPTPIPWLFTDGYDKKITCGVHLLNETIAISIMGNRIYQFTFDLSVTMYNKDKHFVTNHMYMEMGLKFSLKTLNPIFIDMGVSLKSRLDAFTVKSLHENIAMALIKEENKDRRFQIFVKDTNHNCYRGACHSTLTNKVIANFQLKYDQHEKFKFVNIIMISAENSAFVIIIDKDSKGLHFQFINTTCTNAYTFGYICLLKSKRLRAQNNEDHCNSDDDMIIGQGSINHVQFSQIEYGFTGGGILHLVSYQQKFVLTVDQRLLYIFDQDYPYQIISFLDFFRCRKWDIVFENENNTVDDVNKLATVDTNDDNVDNDKHNTRGIIIIIIVVIVLAITFIIFPIYFFLHKRKRSRSMMKRSMPWNKAIIIISSASRNESNSSLSSFSSSSSSSSPLSGADDRRNSRRQRRRNTIDKRRIIRGTRSPNLDSSRNLHTTTITTTTSPPQTIMTSIGGSPNTTSDLLFPTMNNSSVAKSPHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2V4</accession>
    <name>A0A922I2V4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_005136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2V4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF18">
        <property type="entry name" value="IPT_TIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9521482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="871" mass="96527" checksum="776B0A783E338A5C" modified="2023-02-22" version="1">MADYDIGSYSIQTINNNNNLTSSSSSSNSYQYPVILNNAGIAISPSINDRNNNHHYIVPPPPHQTHQQHQQQPQPQIPLSSGSSHHLHNNHNHHLNNPNINHYHGVDIDTATIVSIASSCIILISGCIAVVCLIMYMKKTDMLYRSRTCAKCGAHVANSATVSSASGNVMTTNNNVHETDGGLPSGTPISIRSENAVRSVERAEHVAKVINYQMTAKSQPNLAKEIDSIVIYRQGMTNNNNNNSQQQQAIQQTSKQQPLTTTATTTNDQIFNNQSTAQNPATCLDFLADAFKNETKTSFIDDDEAAPYATFNLPGFESDSKISDTYETFAAKFSEPPYMLLKKGIECPPQYADSIDCKLRMLENVDKNSDPIYQSSNVLSHYHSIASCGSSNQDELIRAYEYGKEQKQKLLILQDEVIKQLAQESDLLVAKESSIYGRSIPISDHESPTDPGIREFTKSPPKPNEKRQGIVFHHQPTVVDILKMSHHLIDSKEFSAKTSLTHQQPEVESSSNETSKSLSSLKASSGAGDDDDDDDDDDSTPSGGSDELGNDEASSSTTPTPENLSDQQQQQQQPLGNSSSKKNFGAISRDRSRNPSWANYTTMKSNTVLAMPSTSSVQQPSIYQQQQQANINKRAFVTIPDMATGKEFSSVDIDDDDDIVDDDDDDDDGDPLGNARNIVHYGTRKMAKSPPLSPTSLLDSIAQHMKQTYGSYDYHPIDTSSMNRINLDADTNNRQKQQDIYAITKSSYEDNLSLLLAAEVESVNNSSSNQSTEIINVDLNDNNESVNNNNMNNNHQNRLNNHNFNNNNDNYHHHHRQQQQQQQFVSLNKCSPKKITTQTSVTTNDNDSSTTTRMIDIKNDRIIKITSEIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I316</accession>
    <name>A0A922I316_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UMP-CMP kinase</fullName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate/cytidine monophosphate kinase</fullName>
            <shortName evidence="9">UMP/CMP kinase</shortName>
            <shortName evidence="9">UMP/CMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CMPK1</name>
        <name evidence="11" type="ORF">DERF_004764</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>CMP + ATP = CDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>dCMP + ATP = dCDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I316"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009123">
        <property type="term" value="P:nucleoside monophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="72"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>CMP</name>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9521086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="269" mass="30579" checksum="26AEFA2A7F821A59" modified="2023-02-22" version="1">MSVIIIKRWLSYSRNCIVNLYLERSQQPNYCLVLLSKIHGFSLTYRFFNNCKMYDWNNLPRPNVIFVLGGPGAGKGTQCSLISKKFGHVHLSAGDLLRKEQNTAGSQYGELIAEHIKNGTIVPVEITCKLLMNAMLENMISLAKVVNGTDKPIAVGNFLIDGFPRNQDNLDGWQKFVGDKVKVELVLVFECPEEVYIARCLKRGQHSGRADDNPESMKKRLDTHLNQTMPIVKYYEKLNLVKRIDSSRSIKEVHEECCKILQSLMGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I330</accession>
    <name>A0A922I330_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase</fullName>
            <ecNumber evidence="2">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4'-phosphopantetheinyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MED31_1</name>
        <name evidence="11" type="ORF">DERF_008771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>apo-[ACP] + CoA = holo-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:12069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + acetyl-CoA = acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:46565"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I330"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000003">
        <property type="entry name" value="L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="10">
        <location>
            <begin position="73"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="9">
        <location>
            <begin position="197"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9518175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="375" mass="43945" checksum="DD5B327EA086FAF1" modified="2023-02-22" version="1">MDSKVAQNRSAFHQYYLNRFPLRFLITRLFRIFISGELSRRKLVTMMVNSVCEKQGCSNKDTGILRWAVNTNRWQPTRTEWLTAMRMVDNDHERNRINRYIYKKDAKHALVGRLLIRKCCEHFVGSKRFCLYSSNNSESSFVDNEDQLILERSDKGKPILIEIDSNGNHIPYQDFQFNISHSGDYCVLAADSSTTKLGIDVMKVEYSGGMHKLNDFFNIMRKQFSEDEWKYIRQSSSDYGRLARFIRLWSLKESFVKAEGSGIIFPLSKISFVCPSDLVMPSQKSRFDSIVNVLNGNYNSQQTLSNWIFEESMIDPKHYVSVAKLSQNSNAEELKTDRDYQFRMLSIKDLIPDFQYSDLHSFEDESYWIDFCQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I390</accession>
    <name>A0A922I390_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smad nuclear-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SNIP1</name>
        <name evidence="3" type="ORF">DERF_008855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I390"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="193"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9518265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="299" mass="35770" checksum="CE912B00F054001A" modified="2023-02-22" version="1">MDHYRRNNDGDRYKSRSKRDRPSSSPDNRKESSLRELKEKARRERHYHHRDRNRGQDNNHRQARLSDRKLDDKSRNPSRSRSPHYHRRSFESNTRNERERSDSFRMNHRRHDDDEFERKKNNDQTENEEKLPEIRPNFELTGALARDTNTFNGIVIKYNQPPEAKKPTKHWRLYPFKGSEALDHINIHNQSAYLFGRERRVADIPIDHPSCSKQHAVIQFRSISVERLDGTTRKVTRPYIIDLDSANGTYVNFKKLEPSRYVELFEKDVIKFGFSSREYVLLHSQSQADDDHDDDDNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3C6</accession>
    <name>A0A922I3C6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_005122</name>
        <name evidence="5" type="ORF">HUG17_7634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3C6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7637428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9521464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="240" mass="28743" checksum="ACD1BEEC85E33F06" modified="2023-02-22" version="1">MDFFLIFCDVCYKSFPETKNQLKYLLTSCKNILCHNCHLSSKSICPKCHQERCRRIMITNELKESIRVYFNTDGKHSIDIGPKIYQFQKMRFKRFEHFLLKKYEHYYSQVNESTIQLQAIEKNKIDRITQLKQMIAHHEQLCRKIIHPEQPQPVEVREKQFKGPIVFKTPQNIPHRRRRMERPSVVNSQFDHHDNIYCNSTPLPGHEYYIDGNIFFDNKPPSSIFSGTTARSNRYRFGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4F6</accession>
    <name>A0A922I4F6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_005007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4F6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050433">
        <property type="entry name" value="Myc_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002418">
        <property type="entry name" value="Tscrpt_reg_Myc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45851">
        <property type="entry name" value="MYC PROTO-ONCOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00044">
        <property type="entry name" value="LEUZIPPRMYC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="375"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9521342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="455" mass="51809" checksum="FC58D624DCC618E9" modified="2023-02-22" version="1">MFFNEDFSVDPTDIDVTDITNSFCFEEIWSNFIPKPPQSPPFILNCCEDLLNDEKMHLDEEIGKNVIAHDCMWSGQFSEYKCKSSTYSLNDITNMNSNNNSESMATFFRPGTPFNLSTSPQSAFNYIHSCDLNMNENYTVDDDNNQQQHDQQQQQQSSNTVTSSNVYAMTNDHSYGLSQQQQQQQKITIMSDLNEKSLIHKDTKSIYRKPMENKSIGQPRMSKMRCKKLSNSNRKHQQQQQQTSSSSSSLLNNNAVSSSNVSIKNGIKKENQNSVIKTTLVSSSSSSNIKNFQPLKRKNPNTIVQHPTSISTSSNLSRVILVKNLATTSSAAVNLISNLQLNSPACSDSEESSLSFLSGDGCEQKLNGGGSSPPVKRRELNDLERKRRDHLRNSFNNLRDQIPKLKTSQKKPPRIMILHEATNYVQDLIHENEQLEHEHRIEIEKRNRLMEILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4I9</accession>
    <name>A0A922I4I9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4I9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009533">
        <property type="entry name" value="FAM107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06625">
        <property type="entry name" value="DUF1151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="265" mass="30831" checksum="034036612C5E02F9" modified="2023-02-22" version="1">MSSLPRTNLFHDVGNNNDSDGNHHHHHHHQYSVDNRSSTSNSTNNRFDQDGLILPKKLSNPSLESREKKEMHREMLWKMKHGQTNDPRRENEYRRAFQQYQQRQRNKEKEIESTSYEKMLETQKQRLNSVTISDLIETNIDNNSSSSSSSLSMDNHFHHTQISHRSSLPNNDNKEFHRILTKLRSTSSNNNVNINNNNNCNNNNDISNPNNLYFTNDKNNNNQNDKNRNKITKSISNTLTNNNNNNDNSPIKSIGNTTKQTNSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4X5</accession>
    <name>A0A922I4X5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ABCB1_2</name>
        <name evidence="18" type="ORF">DERF_005240</name>
        <name evidence="17" type="ORF">HUG17_3710</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6494403at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097254">
        <property type="term" value="P:renal tubular secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017085">
        <property type="term" value="P:response to insecticide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000916">
        <property type="entry name" value="ABC transporter B family member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="819"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="926"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="27"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="370"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="699"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1069"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7639677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9521597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1310" mass="147298" checksum="5759E5DA14DDC34E" modified="2023-02-22" version="1">MKDSNKSSASLGQILKYVKYMDYLLILIGSFGSFLCSLTWPGLTITFGKTVDIFVNYEYWYHNDRVMNKNETYIEQRQQEYMNEVWKYSGLTGAVCIMYIVGNFISIYSFQILSLRLTRNVKRLYFQSILKQEIAWFDCQKSGEFASTISNDFKKFEQAFNENLALLIYQSFSSVCHLILGIYYGWKLSLVIMSVAPIMIISSITMTKFQTYFAQKELQAHSAASSVAEEAISAIRTVFAFGGQEKERQRYESMLKPGMILACKRNFVTGLGMALHWTIIYIALGLGIWYGVRLIISVDDIYTIGDVVIVFWGVTGCAFSIGYAAPFYESFQIGKTSAKNIFDVIERRSEIDTSKNFVGKKLPKDYKTDIEFRNVHFSYPLRPSVKILNGLNLKINSGEIVAFVGTSGCGKSTTIQLIQRFYDVKDGVVMLDNHDIRHLNVGWLRAQLGVVGQEPVLFDTSIEENIRMGMPIDQMDNVTIEDIEQAAIAANAHEFISKLPDKYKTYVGDRGTQLSGGQKQRIAIARALISRPKILLLDEATSALDLQSEHIVQAALDRASQNRTTIIIAHRLSTIINANRIFYIDKGQVVEQGTHQSLMELEGKYYSLVQAQQIQQQTMNETKKLKTIEQLQNSDIVITKRRLSKRFSSEISLGKGQSVTPIDDDDDPIVNQEDFKKLKKFSHMRLLRLIWLDKTFFTIAFITALIYGTSTPVYALIFGEFVAIFAESKDDDFLMTQTLYYTYAFIGLAIGIFICCTTQITLFGIVGEKLTNRLRKMAYSAILDQEVAYFDEQNNSAGALCARLGNDAANVQGATGLRISMMCQAISTVIFSIAMGFYFNWRLSLVSLALMPIVAFASVVSSSIYSQQATKDGVTAEKSSKTAIEVMNSIRTVVSLHKEDYFYDIFDHTLTESYINARMKCLYKSVVIAFAMGAPFFAYTVNFAYGGYLIRDGLLASGDFFKIAESVIFGAMVVGQSAVLSSDFAKAKLAAMNIFNLIDSTPSLMDVNNNNNNNNNGIINNNRKNHNEIYTNINGDSSDKNFQLIRMSTNGSKKQLINQKLMERSKGNILFRGVHFSYPSRPNSQILNGLSFKAMQGQTVALVGSSGCGKSTSIQLLERFYDCNTGRVLLDDKNINEIDIDWLRSQISLVQQEPILFSYSIRDNIAYGDNSRSVTDEEIYRVAKMANVHDFINQLPQGYQTPVGSKGGTQLSGGQKQRIAIARALIRDPPILLLDEATSALDTESEQIVQQALDEASKDRTCLVIAHRLKTIVNSDKIIVIDRGQNVEEGTHEELLSRQGHYWRLYNQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I516</accession>
    <name>A0A922I516_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I516"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="31" mass="3150" checksum="68B8C269AF5FF445" modified="2023-02-22" version="1">MAKKPAAAAAAAAALAMKKNDVDFDDDDGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6Q2</accession>
    <name>A0A922I6Q2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_000111</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6Q2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_RING_CH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="852"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="12">
        <location>
            <begin position="436"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="150"/>
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        </location>
    </feature>
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            <begin position="271"/>
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        </location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="649"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="722"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="778"/>
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        </location>
    </feature>
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            <begin position="952"/>
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        </location>
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            <begin position="151"/>
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    </feature>
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            <begin position="169"/>
            <end position="190"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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            <begin position="288"/>
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        </location>
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            <begin position="733"/>
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            <begin position="958"/>
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            <position position="1"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="EMBL" id="KAH9525991.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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    <sequence length="1050" mass="118206" checksum="01B488ADE40F7F8D" modified="2023-02-22" version="1" fragment="single">MASLAMDYCGQHEQQDNRPNNNNDNDDEENGIYTEKERVHLIERRQQQQQQQQQKPYDDHIHTFSSYEDVLVDSGGDVGSSSSTVVDNSYRSIFNGGHHLQYIDENPDVKHPHTTSEDDDELLQKILSVSSPSAGHHHPHSIICDQHSMINHHNNNNKNVQNYKHSDSYGEDYDDDDDDDDDDDDYDDDISESRQLTRPNNYARIVKCSSINKRQRFLTNNNNNQQMSSSTGKMMITSMDHGVTSKMLLPKIMMNPNNNIMATDITVHAIHNNNNNNNNSDDSEQMDSSAPSSSTSTWTSSMSGSSSSTTGSSSSSSASVVVGDNSVYIMADTISTTSSSSSSSSSSLVTTQSTSSSMINSNSLDGQQLQQQQQQQQNSRQSGQPLLAHNHHHHNYQYLHPYRHYRNGHESIRIGSSCISVHSAVSQASNDSSLLDYPANTPICKFCHQRGKANNPLISPCHCRGTIRYMHARCLMKWLDKLKRRNSRSQPLSCEICNYEYRWRKQFKSPIDWTLPPCMGNDRHWHTIFVICAILMVISTINLVIFGDDEHTHHHYHHHSHHSSRYHFNKSSSLFGNHNNNVADDFSTATTLLPFSSSHNNDNDNDNISIYGKEQIGIDNNIHNMDHSWLSSLTDPAILIDSMLQLNSNDTHDDHHDDDDDDEQKQQHDDQFTQSNSMWLLPSSSSSTLNTSSLLTKLLFRNNSTSDWIFTSSSMADNNQTIDKQQRKHHQHQQQQLNSNNNNKGASSLKNSINTKNPNNKKRLHLLTEKDFLSTVFQHHQSSSNTSNSQFNNSNDNDSSINHRKQNHAIITNRVTGTMVINTDKQNGFNPFHITSDPWRRRKTYPTKPHEVILVISGCLFFISFFLGTFAQIKSEISLYNMIMRFIHWNQQWIIEEYDPSNDDSNGIGTTSVAASTAAGTVNDLTSTTITNITTNNNDNDSKIEMTNCLAQTHHHSSQSPSSSSSSSSSNGINNSSHQQQPPLRSSPSPSTSSTTTTTTTTTIMKMNQSPVHTLLMIETQINNGNNNDGQIISAINERTNSIDKSVIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8J9</accession>
    <name>A0A922I8J9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006275</name>
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    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
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            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <begin position="44"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="KAH9522711.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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    <sequence length="65" mass="7579" checksum="54F664508CDC0384" modified="2023-02-22" version="1">MHHNAREIFKSFQSCLLFFFTFLITQNTRLRFTYNCVDNNVLLDENGEKGEPPPPPPLPPPHVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8W1</accession>
    <name>A0A922I8W1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">DERF_006383</name>
        <name evidence="1" type="ORF">HUG17_2892</name>
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    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8W1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7638859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="127" mass="15020" checksum="97309FAEFDB87B09" modified="2023-02-22" version="1">MYFISKSTILFAISIILIVNYPSLVISRTTEKLEVLDRKLFELLQGRIFVEILEEAVDKLNDLDTCIAKCVGLKSTKRTFNELVNIMRCYDNDRKHTVECKHLKRLRFNVKRKLKQEQCKEIINRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8Y0</accession>
    <name>A0A922I8Y0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8Y0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="107" mass="12501" checksum="0C93F0DFEBE6FF1F" modified="2023-02-22" version="1">MNEFIPHTQLIDQGKFKVVVVVVTDHYSHHLIRMLMINNSNDNQVQKSKKNLYLECSSYVHLILFKYDDDGQINNLYASSSIQQTQKQNTIVIWGEEEDPFTMVINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9K3</accession>
    <name>A0A922I9K3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9K3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="7810" checksum="FE81A9BF9D2A7F72" modified="2023-02-22" version="1">MDRLTCVAIGVVIESSEQWNLTLTDVQLCWRFSLLSVGAYSTVPVCPRDERGCSVSLVLSAARFKYQIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBM8</accession>
    <name>A0A922IBM8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBM8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8660" checksum="872C63ECB3FB4BB4" modified="2023-02-22" version="1">MVNINFIIDIDFNNSYEFILIENILYNKTYLASKILHLFHQSYSVLRLTDYSLTRFLIDVNNYNQLISNHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICB9</accession>
    <name>A0A922ICB9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICB9"/>
    <dbReference type="OrthoDB" id="6504710at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037276913" evidence="2">
        <location>
            <begin position="21"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="187" mass="20176" checksum="DCBF03A5700CEDB1" modified="2023-02-22" version="1">MMKPVHFILLASLFCPLVTGTKTDEHHQPLSSQTQQNDNQKLRAQSRNSDYGKKSNDMKAVADMHSVYQQHLVGPNVASAIAPHESNKNEKKDLWSRFGGKEASNSATSESSNGKKGKLQTVGSVIGDIIGVLVSEIARFFGSIVSDVAREVTAHGFVSLFKQIADITGISRNGHQDHGTAMGSTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICI8</accession>
    <name>A0A922ICI8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICI8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6978" checksum="D5A60136F5EBBC28" modified="2023-02-22" version="1">MITAISSVSSSSSSKYYLYFLSQRLSSWLIVDDRMNEEYEEEEDTKTNKKKGKLSSLQNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICU1</accession>
    <name>A0A922ICU1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_002330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICU1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14296">
        <property type="entry name" value="UBA1_scUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000002">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF29">
        <property type="entry name" value="AMINOACYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="6">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9528377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="244" mass="26743" checksum="B9AD43D9818B9859" modified="2023-02-22" version="1">MDQNRGVPDGTENTDDPPPTSTTTTATGTGDVGDNSLTSSQPSSSSQSKTKWKPNDLFLINLTSMGFSSMMAKKALYYTNNESAEAAIEWIFTNGADSEDLPIELEQKEQQQQSSSLISYENVDDDLYKMVFIVNSELTMGVGKIAAQVAHSALGLHRLLLQHQSKYGESLLCWNEYGETKIVLRGENTNHLVELEHKAIALDLPCYMVHDAGKTQVKSGSTTVLAIFGSNKLIDQITGQLKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICZ9</accession>
    <name>A0A922ICZ9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PSMB2</name>
        <name evidence="10" type="ORF">DERF_003644</name>
        <name evidence="9" type="ORF">HUG17_5542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICZ9"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 8 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7642497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9529777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="219" mass="25005" checksum="E267A34CA5BD7279" modified="2023-02-22" version="1">METIIGIRCKDCVIIATDRVNAFSIIMVKNDMNKIYQLNDNLVMAVNGEPGDTVQFAEYISKNIQLYKMRHGYDLSPMASTTYVQRNLANYLRSRTPYHVNLMMAGYDTQMKKPHLSFIDYLATTVEVPFGAHGYGSFFTMGILDRVYKPDCTADDAMEMLKQCITEIQRRLVINQPVFQVCKVDVNGIEHLDDIVVNPDKVLNSELKLQKPTVQPMIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDQ3</accession>
    <name>A0A922IDQ3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside diphosphate-linked moiety X motif 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_002119</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May contribute to the regulation of cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDQ3"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04670">
        <property type="entry name" value="NUDIX_ASFGF2_Nudt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000027">
        <property type="entry name" value="nucleoside diphosphate-linked moiety X motif 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003293">
        <property type="entry name" value="Nudix_hydrolase6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040618">
        <property type="entry name" value="Pre-Nudix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994:SF46">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994">
        <property type="entry name" value="NUDIX HYDROLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18290">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01356">
        <property type="entry name" value="GFGPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="106"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9528150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="281" mass="32619" checksum="B2212039B3E94E49" modified="2023-02-22" version="1">MEQEKFLDITIKTDIYNGIKIDLHHLSDEIRSKLTVDSFDTIINDKIKVWIENGRKCIWFIVPGQLSHLISVLIKHGFEFHHAKPNFVMLVKWIPNEETRIPKFAHTTVGVGGLVYDPVIQKVLLIQEKNSRVKMWKFPGGYSEPGEDIGNTAIREVKEETGIDCTLKSIISFRHNHTGIFGCSDFYFVCLLSPIKQSSKIETCQIEIDDCRWFPLSEARQHLCGFNRYVFEEFLKQYSFVEYCNDCKDSLGDTIQTEIIHSQYGPFKRDERVYSVRKSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF04</accession>
    <name>A0A922IF04_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF04"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7430" checksum="14C5F7A0611931D1" modified="2023-02-22" version="1">MKKTSKFKMNKEQKKCRHCNIISCHILLNEQKKIQNSVNANFKSINRNDETEKNESVTASRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF15</accession>
    <name>A0A922IF15_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RCC1 and BTB domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RCBTB1_6</name>
        <name evidence="6" type="ORF">DERF_004153</name>
        <name evidence="5" type="ORF">HUG17_9335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7638229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF15"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="253"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="373"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7638229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9530341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="512" mass="59088" checksum="5416DD738DF7520B" modified="2023-02-22" version="1">MARSPIESIDFELFQDDLENIDQKFLQSVVSIFSFFTFEEIYSEKQFLLMTKEATYAYSEEICSWLSLDHDMSKPQRISLLNDVKIVQVDSGHRFVAILTDDGRVYLASNDSRWKTNKTLRLINTGNDCFKMIACEEEHLLLLRQDGHVFAIGDISYCGLIINEKSPYESMIHIDNLENVELIVCGGLHSLSITNNGEIYSWGFNEFGQLGLGDEKNRNTPCLIPFPNDDLIDIRIKDIVAGSNHSLFLFENGQLWGCGSNKYGQLGLGDYIKRSTLTKIPIENVQQIKCSKFHSFSLAYDGSSYYAWGRNNSWSSPKKLDYHPTSFASSSAMILSSPLTFGITSIIYEFGSQDSISYQCKSIIQLFDNQDNYDVKFIIDKKHIKACKCNLKSASEYYDRMFSGNWSENDQVIITDYSYETYYAYLWMLHTGKIHINRQNITELVDLANCYGDERLMKYCQTFIRSDLNEQTMSTYFSLIEKYEMKKLYDKLNYLIIEQVLPKVTDTITEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF99</accession>
    <name>A0A922IF99_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_004032</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF99"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="16">
        <location>
            <begin position="150"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="16">
        <location>
            <begin position="558"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="401"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="493"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9530210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="998" mass="113764" checksum="1724E6F76D0491E4" modified="2023-02-22" version="1">MVKRSTNRASAAGCGPIAAAGNSGVGSTTGSQRGAAASTTCGKCCYYFRQVVTFLFSHIGLCTLLLGYALVGAFTFQALESVHEKEQRIEMRKSRDLLIQKLSNLTNESIILRFDNWTRRAEDILIEFEKGFLHAVKYKGYDGYEELNKTNSQWSFSGALLYSIIVITTIGYGNVAPRTEWGKVVTILYAIIGIPLMLFCLSNIGHMMARSFKFIYWKCCCYLCVKPKKERRRRRQRQIQKHRRRRARQQQQQATIHETVMAMNPLLLSNGPNYLVGPQQSLLQQRISRSRSSQRSDGRQSEKCSMLRNQQPQESLAATETHNSLSNTLQLPERMMLSRSLSARYHNELRARKSRAGKLAQSSKLVPVRKTTVNMPPVICNQYASYSDERLDRAVLASNSMSKRPSVFRSSSMADSGTMARCRQQQQLNAQVRFGQKQQPTSLQSPQPSSSIRQSASSSNLMTSSYQQPTQQRSIPSSDMMMLMQMNHHMSTTTTTTFQPTGQLYSSHPRPSLLPMDISDPSEDKSHDGSHNDLDSDIDNENKEIQEKNIPITVCLALVISYICGGAWFFSTSEEWSFLDASYFCFITLSTIGFGDLVPGRTVLSTHEDGQMTLAICALKLNGFDENMDYFLDTDLNLHHQNHNGSLTINSLALSQVVEQCKLFSNTIIIVNESMPVFDCESIAPVVTSFQYGHKCFTYFSDIYGHLSRLPLDKRPFLEYDMFPSVQIILSPQLMRKKNGTKFSFVMDHIDKNRSNASSLFAMIHDNKNLPSMLENSIRFVLPDNSMAIFYGEKIEQLKPSPFDTNCFEGYDYTLDDKLVNWNGQLAPLPNGFRSSGECFVHCLSGHLNEECINYYSLLTDQWIRRWLQYNHTRMMPFCSLKHMACQHFGYWKQLDDCTRKCRPSCLRRWFTMTKVNSEPYNQTSITLFRSNEPSQLIEHVEATSLETFLGNIGGHLHVWLGISVVEIFNYIIRVIRLRQFSGILCCLYILFKRSRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFE4</accession>
    <name>A0A922IFE4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">High affinity cationic amino acid transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLC7A1_1</name>
        <name evidence="8" type="ORF">DERF_003401</name>
        <name evidence="7" type="ORF">HUG17_5356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFE4"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097638">
        <property type="term" value="P:L-arginine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000010">
        <property type="entry name" value="probable cationic amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF105">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="6">
        <location>
            <begin position="541"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7642311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9529521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="606" mass="67426" checksum="F57DB63288073224" modified="2023-02-22" version="1">MIFLRNFIKSLLRRKRIDSSQISNTRLDRCLTTLDLSALGIGSTLGLGIYVLAGDVASRTSGPAVTISFFIAAIASVFAGLCYAEFGARVPKAGSAYVYSYVTVGEFMAFVIGWNLVLEYVIGTASVARGYSNYVDSLVNGTVQANLRYYMPIDVPGLSAYPDFLAFLITFSLTIMLVIGVKESTRFNSVFTGINLLVVLFVVIAGSFHIDFHNWNLSKDEVPENAGKGGFMPYGFSGMMSGAATCFYAFIGFDVIATTGEEAKNPQRSIPISIVLSLLFVFLAYFGISAVQTLMLPYYLQTEEITKGAPLPYVFEYVGWPVAKWIISIGALTGLSTSLLGAMFPLPRVLYSMASDGVIFRSFADINPRTKTPILATLISGIFAGAMAALFDVKELADMMSIGTLLAYTLVSISVLILRFSHEIDNIDDDINRNITVEMKPLRSKYQNSDEKFDNRSWCAKLFNTDRMKEASAQTSRISTNLVMFITTVLIIFDALLVYLEDRLVELETNSFIIILAIFIVLVFSIISLAMQPRSTKKLSFQVPWVPLIPILSMFVNFYLMFKLSTTTWIRFAIWMAIGLSIYFFYGIWHSNERSRRYEARQNSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGS2</accession>
    <name>A0A922IGS2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGS2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="7002" checksum="B6C51BDEAB25A7E8" modified="2023-02-22" version="1">MKHQKKVIVLRMRQMLEQTECSEYCFQNQPILVKKIDGCLLATLGLCAQFSIFSDSCVCKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGW4</accession>
    <name>A0A922IGW4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tyrosyl-DNA phosphodiesterase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TDP1</name>
        <name evidence="13" type="ORF">DERF_003691</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGW4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="12">
        <location>
            <begin position="611"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9529829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="699" mass="81812" checksum="67ED98142BD42A28" modified="2023-02-22" version="1">MTPLDWYTVTQGIWISPKLKKNNLKEDTSKTNFKNDLIQYLKAYEHKSIVMWINIIQEYDFSPINVFLIGSICNSHGNDDRESFGHLKIRKILRTSHYGPTNEIKNWPIICQFSSIGSLGKTPQSWLTAQFLASFSATYNDFNGIKPELKCIYPTIEDILNSLDKNGTCFPYVKSTADKQPYLNDFFYRWKASISDRNNVMPHIKTYARISPDNRKMAWFCLTSANLSKAAWGHLVKIGSKLRILNYELGVLFLPKLMINQDSFSISQNNPLFLPYDLPLVKYDPENDKPWINNNINTFTNIDTNISNGHMTNVDVNDSMTLLRNSIASAACIDNVNFRCQFFRIICDEKYLFIKAIQSFFDRQFDDLYTKLVSNSIVENDDVSLIFLNFYKLEKSLKNDHIQYLLKRLTIVYTALLFRCLSNDTVRMNGILNETMIDTSFWNPLFDHIESELSEWSLWIFFLVLKDEKFAKNLFCTISTKRQIIFLDICMEFIDDECRKHEKISMKNIETIEPDDCLNLFGCQLCPLPKEFIEFINQLFHHQINEYFLKSNFDDNSHHDDLLDLFENLLDILSCFHTMSNDPESIFYTQDLRTSGQQKSSLVENQAIFGFKRNIIGLIANYLHENFHAQTQLRTSGRFIALLNSTKIDRNNPFILQWTIFAIRNALKDNIANQEFVRNLQKQTEIFDNEIFDKIKFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IH18</accession>
    <name>A0A922IH18_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gamma-aminobutyric acid receptor subunit alpha-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GABRA4_1</name>
        <name evidence="8" type="ORF">DERF_003854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IH18"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="7">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9530009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="467" mass="55298" checksum="D44D01F9C6D6389D" modified="2023-02-22" version="1">MKHFVCLIAMIRKKPPKSSRYKPIKIAVNLTILDTTIDKLENVIVLDMQLKERWKDKRLRMHYYDDDDYDTVDGIGGQKRRKMIENFVLDGKYLTKIWHPISHIRNNAHVTNALFDKPKQTLQKIIEQEKLVENIFINTNETTAFVWISLKMRVNIPIYECHRDDSRMFPFDKIECTFHITNALYDKRTLIYEWDNVKWNHNEYHSGQFYLQQLQTSIVNEPIIELDESGNEHSIMRIDFMLNRQIGDYILNIYVLHIFLLILSISIFWISIQNIIIRISLSIIILIIIKFQTFQTLKEEQRIITALSIWTFGLSFLIIMAILCHILSYYSFQHKWNEKILDHLIEKCRHQSSSTTTSISQSQSPSMTDMNSSNEPTNDDRINNLSSSSQTSSSCNDKSLNEKLKLIKKQWNKWKRNLLIRLNSMIVNNIKSNHSYDDTNIVDIISRIILIIIYSMFIVIYFIKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KTF1</accession>
    <name>A0A922KTF1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 15">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">KAT7</name>
        <name evidence="19" type="ORF">DERF_016047</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 15"/>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KTF1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070775">
        <property type="term" value="C:H3 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005705">
        <property type="term" value="C:polytene chromosome interband"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="18">
        <location>
            <begin position="555"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="185"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="312"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="189"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9491319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="838" mass="97429" checksum="8A2C8FCB1612165B" modified="2023-02-22" version="1">MLIRFRLRSSSSSNSTTSSISERSMAIDSSCSPSSLSSTSTSCMDRDQLLGECYLCGQQDDNEGRRQLLTCSVCATQFHLKCLDLKSKQFCDTKSRAYKTWVCRKCRRCLWCREKRTKINPNPLVSSLRSHPERKLNSMEMISCIECDSSIHLVCFFRQQNDRHQLPPLSIRELRKRRKNFICPQCTGDEPDVDEEIVEDEEEEEDDDELAEDEEIEDSSDENDNGDEEESSHNESDDDDSDNSQQKITKHQILQTQLRNLGIDNPDKFIETIQNEQNHRTSISTRSSRRTFQSPMIMEKSGQINKMIDTTDEKNDEQCQNQSQQQKNRKRKKSESEHQPPQCSPKKIKCVSPSPPILSNEQETLPSLSAQHFHQEPCGCSVSGCDSNGHLSGIYDHHSTVETCPLFHNQTADDCRQRYRRRIECQRQIQEQQQQRKCWSSPRKSIQRLGLLQQKNVKWNQIMNQRNVELKSLQLETKPTFTSSRQPNLEGLTPKFDLNLFIDAQARTAQMIHENSALELATTTTTTATKMANDSNEMKTSEQNFDENQEIQQQKKKPGIETIIFGKHEISVWYNSQYSDEFQNCLRLYICEFCLKCMNSSIILDRHMEKCTLKHPPGNEIYRKGKISFFEVDGNKQKEYCQNLCLLAKLFLEYKTLFVDVEPFLFYVMTENDHTNGIHLLGYFSKEKHSPNSYNVSCILTLPQYQRSGYGRMLIDFSYLLTRNENKIGSPEKPLSDHGIISYRSYWKFVIMDFLSSYVGKDILLKDISQHTGINSVDLISTLQLMGILKYWKGKHLILVNDEQRKRYGQEIKRKRKLFGDKMIDPKCLRWTPSIYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYG2</accession>
    <name>A0A922KYG2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Trafficking protein particle complex subunit 6B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TRAPPC6B</name>
        <name evidence="4" type="ORF">DERF_010708</name>
        <name evidence="3" type="ORF">HUG17_9652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7642961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYG2"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7642961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9505945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="154" mass="18092" checksum="664E0622D8ED665C" modified="2023-02-22" version="1">MADDILLDFLHMEFVSLFDEMNGEEKPNDLSRQESIGYQVGFRFIKKYTREWNRFKDELEIIKFICKEFWSAIFGKQADTLRTNHQGIYVLIDNQFRFLKRMTDSQQYMDQIGKYLAFSCGLIRGALFNLGIPSVVTTDVSQPPSVKFQIKIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYS1</accession>
    <name>A0A922KYS1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CWC25</name>
        <name evidence="9" type="ORF">DERF_012696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYS1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9501887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="352" mass="41647" checksum="5ACBFC7A9B498A08" modified="2023-02-22" version="1">MDWMYKGVSGHVDREDYLTGRKIDKSFEMIDREENPHLHRNDDDEFCLPTTSTSTSMNDNLEQSIMNMSKTDIVAKMREDPLFQIKMKQMEKRKELLKNPLKLKKLKNLLQSSLAKEEKSKKRKKKRKSSDKKKKQRSKKSRKHSKHSSTSSSSSSSSSSTSESESSDSESDSNHRSKKSAHRHHHDNRDQRKHQSDRKYHSNQRQSESTRRHSNNDSHDRYRSSKSNHQSLPSLSKNKSKLTEEEIERKRREMMSNAEWREQTRSEKVTKLNRRDHLEDHLARESFRRQHDNNNDSDDDHGNHSGRNNSGFIRSMLSKMADKNTVERSIQQKRFHSQRDHTAMDRNFARKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZ01</accession>
    <name>A0A922KZ01_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_012851</name>
        <name evidence="5" type="ORF">HUG17_8586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZ01"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF286">
        <property type="entry name" value="GH22266P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="870"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="899"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="937"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="965"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="795"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7637482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9502052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1004" mass="109364" checksum="3EBC9DDCA02EDBE9" modified="2023-02-22" version="1">MPPHAGTPSNSNSSLPLYHSVLLSISGDSKISLQHTSVQQLSAIPEDRELVDVGGGGNDRQQQQQDENDGTFTPQMIVDDEFDEPHVLIQDPAPDGGYGWIIVLASFFCNLIVDGIAYTFGLFFEIFVSHFGVSKSKVALCGSILNGFYLSVGPLVSSLANRFGCRVVTIMGAIISFIAFSLSTIAPNIETLYITYGFLGGVGMGMIFLPAIVSVGYYFTSKRAFATGIAVCGSGVGTFLFAPFCQYLLGVTSWQNTLLILAFMILSCAGFGGLMRPLNVHAKTVLGEGELDDQQQMMENSEMRKPLLQRIAEEKRRRLLAHSNSQFLLMMQHGSLDLNDLTFTELKNRLNSMNMEPGVHSTLYLDQLFQPPTPTPQTPTPSAANQNTDNNKDTVTSQQQQQQTCPSTTQSQSQLCIDQKHQLSPIIESKKIFSVNSSEDNTSSDENITIKENNDSEQQEQDNNNNDNDNEHEQKKMADAAGAVASDYSNDYEDEDIKSEINTPTSATPESPPILPQSPLSEIGNGRSSSALVTNNFIIQPRSRRSTVRTVSESGQVVDSSNYLPSSSLLPQMNSMGTSGQLPIQVILSSTPAGATLSSEESKDKRNITIQAIPVRPLSKKDIFYSGSTLHVPSSLQHLAESGANIGQSIVSIPARDIIAKVQKQIQQQETGGADDDDDDGGGGGLKRSSYQKRNVCDKILRVLCSFKDNCCQNNQHQQLSNGNNNIDDQNESGDCCSEMNSSIKQQRQFQQQQQQQPNDEKRGYWNHFLSKLPPSMRSILSEMLDFSLIRDSNAFIILAISNIFGMMGFYVPFVYITQFATSSVMAGDKLVTPDQAALLISIIGITNTFGRLLFGYLSDRITKNGSICGLKITALGLNNICVILSGLAVIAAPFCTTYVAVIVDCVLFGLFISAYVCLTSVILVDMLGLEKLTNAFGLLCLFRGAASLVGPPLAGALFDMTQSYHITFAASGILLIISSIMAFFIKSTGDRTVEQEQDNECDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZ30</accession>
    <name>A0A922KZ30_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SEPT4_2</name>
        <name evidence="3" type="ORF">DERF_013788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZ30"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="419" mass="50468" checksum="FF84F9EFE449501E" modified="2023-02-22" version="1">MNHDERPMLFLGKIFDFIKWKFNSLQKNINDVREKRQLLKKMNDEFDKKIIEAHLIGMTDDELATIFDKHFHHHHHHHLNHSFKFLQRKSFIIWLSFILLLISFLLTSNTCKRYGMRFGRKILFQLENHWNCSEKSNERCDYCENVNQIIKINGNSYDQQQQQQRRLLHDQITSFITQKLPFIYHDEHFVTNEIRSWPIRKNFTRIIDFKRLYNETNHHHNYGICMFRSNLVNVNDPYEFFNEIDDDDDDGHSYIHHMPWFIHWQNCGLKEMKKIRHLYKRLSILPPMIEMSKPNWLLLSSSSSSSSETINQRTFKPIIPSQQTDIMVIIQIQGHIEFDLHTAIDDCQYICQQQKNNSTYKRIYYYLPANHLVVIDPKYWRFSYRPPSSSSSSIKEDIKNMDYIDTTMNLSLILTGIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L032</accession>
    <name>A0A922L032_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sterol O-acyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SOAT1_3</name>
        <name evidence="10" type="ORF">DERF_011184</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L032"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF8">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9506453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="733" mass="87641" checksum="39D5E4181C96F6E0" modified="2023-02-22" version="1">MFANDANLRTIHNMIVMLVIVFLLYTIEDIIKEPAKYEEIYKVILWNVSDLGSVIRIWLMMNMIVLGLHYPLVLFNNFLQYRWLLINNPENDKQYAGCLHRTILYTIYGCISIFGILIYCTYSVLINDIKLTGSFSLLLEMTRLLMKSHSFFVEKKDLYIDKETLACLISQEPKNIYRSFWSLSSRAQFWKFIYYLFAPTLLYRDSYPRTKKIRWICAVNFGLQFILTVLLMFYLTYQGFVVNLKKTGIEPLVLNFKLLYQIIAYGIILYWLFFYFFFHAYLNFTAELLRFGDRHYYDDFWNSKSAQEYFRKWNHVVQQWLYVYIFIPIDNRFHNRVLTNVAVFITSALVHEYIIGFTLRFFFPVNLIAMIVLTQSVYFMEKFNLIKTINHFLIVSIVTWSIMVAIFIIEWYSRIKCPLPTELFNIMVEHTMQNNNNNNNDDDDGAQVSKTNKFIKFKHRESYVTQLLENDANLRTIHNMIVMLVIVFLLYTIEDIIKEPAKYEEIYEVILWNVSDLGSVIRIWLMMNMIVLCLHYPLVLFNNFLQYRWLLINNPEKDRQYAGCLHRTILYTIYGCISIFGILIYCTYSVLINDIKIDCKSAQEYFRKWNHVVQQWLYVYIFIPIDNRFHNRVLTNLAVFTTSALVHEYIIGFTFRFFFPINLFIFFCSQITYYLEKFGLIKGMTSFPLSLTMWSILVAIVTVEWNVRTNCPLPEKSSLLKHILPRFINYVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0V4</accession>
    <name>A0A922L0V4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glycine receptor subunit alpha-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GLRA2</name>
        <name evidence="15" type="ORF">DERF_016034</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0V4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="417"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="618"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="265"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="708"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9491305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="822" mass="95656" checksum="54C3AD4DB8BB913E" modified="2023-02-22" version="1">MSIEKAGHICLTTLEYAFERSRSLTTQCPSCGLRLIIRYDHLVNRASSLGVIIGISALIGYHLGANSGWINQFSRKLIRFFNFRNDPESQQRRQRQQALDMKKIFRKYDYQTSSSSSLSSSLPLQSNDSAFNTMQSGSDYEEYDDQLYDMFTYNKYYDDDLFTNLNSPSNVNDNRNRFFHSKTVDKIDQVLHQIDDIKKSIVEIDDELYHVTGSKYANFNPDFFTLADIGWDDESSSFSDGGPISVRNTNMIHSTMDMNNRNSKSIYRKRKHRSINNNNNNNKGEQYSSRPQMMQTPTTTTNDHHQQQQQSTYEYYDDGEMELEQRRSSRQSFGSTETNIQQLEWDETECEFCFHYQSTSTAMDSNEPLLIDDKSIEQIDQTNSSSSSSCSTMITQPIMMTDEQKLQNMQDLFEEAKHLNQVEIGLKLLHFGPVDEKKSQFTVLVHVYTWWNDHRLSLPDQMANSTRLSYLDVDWTDITRIWRPTIHFANAVPFTADILTDKLSGQISGTISGDGRVFLIKRTQLTASCKFNIKFYPMDKQQCWIEIESNSMTARNFQMKWLDEQPIEIPDNFNWANFGLKNLTTQTVRMTYRNGGPYVRLAATFELRRHMTHHIFNVYLPSTLFVISSWSSFWIHIPAAPARVALVLTTMLTHVTSTKAVLDQIPRTKFVSSLDIWIIMCTMFIFAAIIEYATVNYFYTKPERIQDKKSRSNTTTMPNRQQQQQQDLSSTQLDINGNRPDSSSSNNTNSSNNKSMAKFVYYWHDIWQKILPPFNNNDDDNFNAKKIALKIDHRSRFIFPITFLLFNIFYWTILAIYSDQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L183</accession>
    <name>A0A922L183_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FRA10AC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L183"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019129">
        <property type="entry name" value="Folate-sensitive_fs_Fra10Ac1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF25">
        <property type="entry name" value="PROTEIN FRA10AC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09725">
        <property type="entry name" value="Fra10Ac1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="40099" checksum="821C214F1DAE50A4" modified="2023-02-22" version="1">MNDSNTQNESKQSVDSSVNKRKKQDIDDKDGKIFKKPKNIRNSRSNEILKTNGSTTMMINEFSNDEKPRQRNFHSLDQYTRHKLLINYYCLTHPGSRHQVFQRDHSQDKSDLQILIENHRFIWPDEDLQSNQLTWGQRVAKKYYERLFKEYCIIDLSLFKQNKFGMRWRTEPEVIGGKGQFICGNKHCSIPTNLTSWEVLFGYVENGEKHSALIKVRLCPDCSTKLNYHRQHKKAKKNKKNERKLKRKESKNQKQSMVKVKEEILTSDDEVGFSKNPGSSSLQHDHNNDDNDDDETYEQLIDKIWRQPIKLEFDNDNDQEEGKKLENELDNYLDEFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1T4</accession>
    <name>A0A922L1T4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Death-associated protein kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DAPK1_1</name>
        <name evidence="13" type="ORF">DERF_011613</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="9" id="KW-1053">Target membrane</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="474"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Roc" evidence="12">
        <location>
            <begin position="548"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="102"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="607"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9506902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1381" mass="156466" checksum="5D4118F80CCC7329" modified="2023-02-22" version="1">MLEILYNVYLKRMSARQCLEHQWLCYPDESSSSSSSSSAIIKRQSTINDNCDNIKNYKDSNVGNDERIMNENVRRRWKTSIYLIILYNRHLKRRLTSLLLTQNNNNKKSINRRYPQNHHHHHNHHHGQLKSKHGSGGSAAISYCSASSSSSSSPTTTMTTSPSSSLSLMYDKRSKYIHHHHSHQHSNSSSRSSTTDGGMFNNDNDENFILAALFGAIEEGNLHSIQELFTASNIDPNQCNKHGESLLHYCAGLGQLEIFKFLCKIDANINVVDDQGDTVVHWSARQNHSNIIRYVYEQTASIEMLNKNNETPLHVAARYGHVEAVEQLCKCGANINAIDEHGETAILIAVWHGFPKIVHILGEIGADTNIMNKEEESALHVASARGHYECVRCLLDAGANANLRNKNSYTPLHLALKRQHQMVAMLLLKAGADYELPDDNGERAIHYAARYNLVSIGQWLCQMNRCQVNVPNKHGLYPLHIAAKSGHIEIVRTLCLAGSVVDQKDKDSIIPQICAIAQSHNDIADLLTRLRNERQKEEFITQLMPIPSNQPLPRIKLKIFGHSGAGKSTLIESLKCGYFSSWFRRSKGLNSTISLMKLNNINTTMNGQSQQQLNRSTIEPPPPPPHQKNVSKTNGCELGRSNLSIISDGSMTSRDHHSTINNNNVPMMKQQQQQLNNGIMTKMMNRTANINHYQHPTQPNHHHQTQTKGIDCQQMYISGVGDLSVWEFSGHPAYHQIYDHFLGDVHCLHAIVFRLCDAIEIQLDNIFFWLNFIQSRMPISEPLLYCGKSQHYAKIILIATHADLAQQTFVPDEIEQNLQQIMMKVMAKFKNVFEIYGNIFMMDASVAGSIGMKQLKQYLNHAKLSIVQELPHTTGFLDSVLTFLNLYRKVSPNFPVLSYDQFKDMIRSQINPLSSEDHFKELVQQLEIMGEIVFLRSTNNTNYDSLVLNPKWLNCDIVGTLLLMKDDPNYMINVNKTQIMGIYSIDEFQERFDDVDALDLLQLLELLGICTPNDRSGDIEYEFPCFILDGDWEELLDRFQYRDNCVYHGIVFHLQHSLSSSSSPSFGCILTSVFPRIQANLRSELRNHSTYNVYDLHNCFKFSHFTIEETNIMFIISLNTTAQSIEIRFSGPYDKRRECFFFMQEMIQIIEQTVCRCAPGLNVAKSYLSPVQIKDQRENLSFYSSSSLMKSLLFGSNKSTTNLLKKKIQTDDAECEERIGDILCFGICNLNEINVSSNGEPTLANELHSSNLSLLTKQKLCSLLDPPESIGRDWCMFGILLGMTDKLPKLDPGTNAQLSPTARVIEECVRNVNCTIKMLVEKLSELNRFDCVDVILNTGPLLRMFPSTSLPEEGIIYNDESSHTSLGVSTLSHTSSSNLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3J4</accession>
    <name>A0A922L3J4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3J4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9510445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="181" mass="20817" checksum="7CEA99ADE9201F84" modified="2023-02-22" version="1">MMIVPALSSRNHKILDEYQQQYNMSTKLSNMNGNNYHHQQPFDCQQVEQTPARSNVLSFDHDYFHIDNGHDNTLAFVDQSTTSSSKETRDLCTNPKDSLITINYDNPNDEIGDDDMNIIQNHSEQQNSSSSNENLITMNLTKNKKFPCPKCSFGFDTSRNLDNHRHRRIHTCGTAISMFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3R6</accession>
    <name>A0A922L3R6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007937</name>
        <name evidence="1" type="ORF">HUG17_2231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3R6"/>
    <dbReference type="OrthoDB" id="10569558at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7646693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="246" mass="28948" checksum="ED066F368B6CACD9" modified="2023-02-22" version="1">MALITEFCNSYDDYKSCLEYMSDHQITTVEDFKNHLVLNAYSFLRLFKSISLSKLESDLEVFQIEYEKKMFMISTQDGNQIVYNCDHPCCSVLNNKLNEVLNELKIIKSKNEELESWIKQELKKVDNPMVIQQARNAGDFLLEEKWLVKYEFLQNAANDCGKNDLANLMDSVFGKKFLQKYKSYKDLPSDLRNAIDTLIERYVRAKIQTIGGEYGKILSHAKQRLNKRFDNWARYNVKKKGKFFHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4T0</accession>
    <name>A0A922L4T0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4T0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="349" mass="40983" checksum="87B97BFE96173B79" modified="2023-02-22" version="1">MDTLQWLKEINDNDYLEIITIDAVNVIIYDKQMRVIRTSSLITLSNLMEPLSSITRDILRICHYFRIDNHTIISYSIELFDRFFENILDLAISKSFIWLGNESIDLTERVDFGSKLKMLIDSGECFDYLYLIIFGLDIPMNIRDLYGRNDYRTLCIAICVLIASKLHGERSSFSSANIIHLMERINAPAEFCTRNNINSIEVNILNLINFDPNIITLNIFVETLLSITIRYIQTNYPKDYRSINIDHLVKISQLITQNYYISRFEIFCDLFRNEYKMEFQIVVLEHIISLQNLYRDKMLIASGIVSSLFHLKPLETFQHEELLHFLSNMTTIPIDRIGQCRDVLIQRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L586</accession>
    <name>A0A922L586_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transformer 2 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TRA2B_1</name>
        <name evidence="5" type="ORF">DERF_006654</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L586"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="111"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9515879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="295" mass="33344" checksum="2DA2E7772E0BCF9A" modified="2023-02-22" version="1">MSDREDSSEQMGNGGSPDADDRSASQQDSEHESNRSANGHSPRPAGRSRSRSRSNSRRYRKTRSRSGSRGKSRKYSRHSPDSSSRRTKRSRSPMSSRRRHVGNRENPPSGRCLGIFGLSIYTQERDLKDVFSKYGPIEDVQIVYDAQTGRSRGFAFVYFENRNHAVEAKDRCNGMEIDGRKIRVDFSITQRAHTPTPGIYMGKPTHPRYRSSSGGDRGGGSNYNRGYRNSSGYGGSGSSDHHRRRSPSPFHSYSSRDRRGGHTSSARYSRSRSRSFSPRKYPFKRSGRVFMSSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5M4</accession>
    <name>A0A922L5M4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small ribosomal subunit protein uS17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">40S ribosomal protein S11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RPS11</name>
        <name evidence="16" type="ORF">DERF_004843</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5M4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000008">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0164">Citrullination</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 16" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="15">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9521171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="154" mass="18004" checksum="33DC211E91A2072E" modified="2023-02-22" version="1">MKTQQLVGEQNEKAFQKQPTVFLNKKPPTGGRSRYRKVQRYVRKVGLGFRTPKDAIEGNYIDKKCPFTGDVSIRGRILRGVVIKMKMQRTIVIRRDFLHYIRKYNRFEKRHRNIDVALGDVVTVGECRPLSKTVRFNVLKVTKSASSKKQFNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5R7</accession>
    <name>A0A922L5R7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5R7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9518125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7381" checksum="E5D22DA589B3AA43" modified="2023-02-22" version="1">MDYIDSWVGKDSYNFVALLAVELMTRMHLKCFHRMDIVALLEDNSDKLADLRLAGPAVDIYNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6U6</accession>
    <name>A0A922L6U6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6U6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="86" mass="10052" checksum="4D91C3AEDD872A34" modified="2023-02-22" version="1">MNIIKCIMSYVAKKKCFFGRQLIAAKLTMLMIRNGELGEEKFMEIVNVNSMKNEIEEKELQNVNVCITARIEEPIYEKHGHYRLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L726</accession>
    <name>A0A922L726_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L726"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="231" mass="25989" checksum="83925D7824D4F2C5" modified="2023-02-22" version="1">MKIKKNPNRIHSVTKTTKTILYSITSYFNDKFCHTNIHGRSQMDHSVAGTTTTTTNVTRTTIMNRNNNNHQKYSYNRNNNGKKSLTAASPSPSSSSSLMIGKKSYDDHIKQNNNHRNDKTSTTNTTTTTTTSSSSIKLNHNIVVDNSNNNNKDQKPNNETLERQQQQQQLGTRQKYHHHHHVHYALTSNNNNNNNESITPSTKSPSPSPSQSSSSIQHDHSTNSNITDNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7B6</accession>
    <name>A0A922L7B6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PRDX1_1</name>
        <name evidence="10" type="ORF">DERF_000071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7B6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF163">
        <property type="entry name" value="AT16346P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="132"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9525941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="323" mass="36830" checksum="66EA507858FDC724" modified="2023-02-22" version="1">MSINNYCQKRNLNQILNDDDDDKDIEIQSTCDNNNKNYDYDNGHNDDNNINIDNNDGCNSDSLTTKRRRHDCISTNELIELKKQKTTIIMTMSNNNNVDDDETFSFRIQPESASQISITHPEGREMAEYNYPRIQKPAPQFKGAAVVGGQFKEISLSDYKGKYVVLFFYPMDFTFVCPTEIIAFSERADEFRKMNCEVIACSTDSKFSHLAWINTPRKEGGLGEMNIPLLADKNAKISQDYGVYLDDGVPLRGLFIIDDKQILRQITINDLPVGRSVDETIRLVQAFQYTDVHGEVCPVNWKPGADTIKPAPDKSKEYFSKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7G3</accession>
    <name>A0A922L7G3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 4V2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CYP4V2_1</name>
        <name evidence="10" type="ORF">DERF_000208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7G3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9526091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="551" mass="65118" checksum="267AEB30856DF60A" modified="2023-02-22" version="1">MILIVIFFLLVFIIHSFIQIIQWLINQHRLYLIIKTIPGPKINFPLWGNINLLTGILRNQPIGLQSKAFINLMNDICEQYDPNNRIGLIRLWFGPFVPIIIITNANIAQKILNSKDHLDKATFYSLFRYAIKDGVFTSKTEKWLHQKREIQNHLKFKALQRYIANTERHLATLNERIDAVIDDMNKNGQIDDIKPILSTFVLDVLGENLFSTKFHSQSTGVEPKFVRSVNRMLELSYIPFLQPWSYYFNKSILVYLCNLAIFLKTMNYVNNFQYSVRKIILDRFKMKKFEQKSRKQLSLLDSMIESRISSMNPDRILKLNQIETQINTFVVAGHDTTTSALSWALYLLGHHPEQQQRLIKEIDDFLADLNLNGESITLLSMRQLKYLESVILESLRLYPSGPFIARRSRSEFKLNEQTTLPGNINYIIFIQHMHMNPEYFREPKKFYPERFLRCRKETEFEWVNHQAYLPFSGGHRMCLGREYGLMQQRMFLINIFRRYRVKSLDRFGDCQPRFNFLLSSAHFPIRFERRQPQSTPATPSFMTTVSRHSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7Q5</accession>
    <name>A0A922L7Q5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_000474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7Q5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9526376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="293" mass="34329" checksum="A8441C7FF88B6B19" modified="2023-02-22" version="1">MFNLNKSLAKLKSFLEENDLNKKKSKIDNSFKIQPDHETIHKKIKNKQTINGQVGDNGQERRGVVMIKNFPHGFYEQQMYEYFSQFGEVTRLKIIRSRKTGKPKNYGFIEFRFEDVAEIAAKTMDNYLMFDRIVKCQILPPEKIKTNIFRNWNRPFVSSVEKHRLAHNQPKTAKQELRMVQRHLQQIRKMNTFLSDNGIEFECVIINRPNNLKAIKNDDDNGKIQSPEILTKKLIHSKKATNSTDTMPIEVIHMIRPKKRLSSSSSTTLLKRKRLMNAKLMKMKASFSVQKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7Z4</accession>
    <name>A0A922L7Z4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7Z4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="123" mass="13249" checksum="7E932F72E10C4C0C" modified="2023-02-22" version="1">MSLSVTGYAFTLCKCLHCVLALGINLAFNATKLSRAFILIFSTNITIYSSSSKVEAAYKETHSVYGACSNKYITPAGNKVVYRRFGTFKLGYVLCSSTATSDMTSSLADAISPQMGCVKLQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L905</accession>
    <name>A0A922L905_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L905"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="9620" checksum="8A7F09BC9E9AFED4" modified="2023-02-22" version="1">MISLNDDDHHQSTCIKTADDTELSVWPAFPITSETLKHTYPLGYNDLRNQIGTNYVYTHPCGQQIQFESIDKVWKKKENPTNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L982</accession>
    <name>A0A922L982_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_005966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L982"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="236"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="88"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9522387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="296" mass="33520" checksum="710518334283151F" modified="2023-02-22" version="1">MQSIIGHQQHYNPSSSGYHLVTNTLPMSYVISNCATISSQPSSDIMLMSSGSSSTTFNNTNNTNNSNNNQQKMDMNQSLDLQSMRIELEQTKNKLHSKTYECNKLRQQLKQYSTELEQYKQILSSFTQNHGTSANNNNLNPNELLSAAHYKRQTLQVNLSTISSHTNGDGITKTKNTKSKGHAGSKKKNNSSSGNNCQCCCDVDKPYICDWVNCGKRFRQKPHLEAHRNIHTGRRFICDWPNCGKSFVRKYNLAEHQKLHSSVNPNMCTYPDCGKVFSSKYSLMRHQNAQHNLNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9C3</accession>
    <name>A0A922L9C3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ELAV-like protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ELAVL4</name>
        <name evidence="7" type="ORF">DERF_008583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM elav family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9C3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12650">
        <property type="entry name" value="RRM1_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12652">
        <property type="entry name" value="RRM2_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12377">
        <property type="entry name" value="RRM3_Hu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000006">
        <property type="entry name" value="ELAV-like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000005">
        <property type="entry name" value="ELAV-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000017">
        <property type="entry name" value="ELAV-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006548">
        <property type="entry name" value="ELAD_HU_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034775">
        <property type="entry name" value="Elav_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002343">
        <property type="entry name" value="Hud_Sxl_RNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01661">
        <property type="entry name" value="ELAV_HUD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00961">
        <property type="entry name" value="HUDSXLRNA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="49"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="135"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="286"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9517977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="369" mass="40403" checksum="2EDAC9CEF1C067DC" modified="2023-02-22" version="1">MMISSADFEFDDNGGSTMNGLHESSSPINNHNGSIHSNSSVHSMEDSKTNLIVNYLPQTMTQEEIRSLFSSIGEVESCKLIRDKVTGQSLGYGFVNYVRADDAEKAINTLNGLRLQNKTIKVSFARPSSESIKGANLYVSGIPKTMTQQELESLFTPYGRIITSRILCDNITGLSKGVGFVRFDQRCEAEKAIKHLHNTIPDGSTEPITVKFANNPSTNAKALTPALAAYLSPQRRFPGPIHHPANRFRYLHPSISPISRYSPLAGDILTNPLIAANATLNGGAGWCIFVYNLAPDTEESLLWQLFGPFGAVQSVKIIRDLQSNKCKGFGFVTMTNYDEALVAIQSLNGYTLGNRVLQVSFKTNKCKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAK5</accession>
    <name>A0A922LAK5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAK5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="94" mass="11184" checksum="E5697BAAABB8995E" modified="2023-02-22" version="1">MNEIKLNVQQQQQLVLRFCIHLHNLTKQELRNYFEYEIKFANFFVHCIPSYRILLAVLLFIILAYLMISNDDHEFELSVISANLYMNSLQSLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAQ3</accession>
    <name>A0A922LAQ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAQ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="101" mass="11643" checksum="578EB35702B5DA8F" modified="2023-02-22" version="1">MNRSNFESFDFDVDNDAGNHVGSVDFVGAGVDIVVAAAGQTKLIRIYPQKKQKTKNTCFSDHRKRMSHTTYYYSLQMHASFFHRDVHNKRILFPTNAIYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAY4</accession>
    <name>A0A922LAY4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calpain 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CAPN7_1</name>
        <name evidence="9" type="ORF">DERF_002786</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="245"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9528878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1401" mass="160626" checksum="8B8329B996182186" modified="2023-02-22" version="1">MSSSSFSDNGQVILNEAQVLATLAVSYDKQKDLEAAIYFYNEAAKILKKYVNLENVDANEEIEKKISDYEKRYDLLREKQNQILDNELKNLTIKDESDCSVQRLEFLLKEALNEDEEGDTDEALPLYLMAVETGLKAKKEIQDPRLSERLTLIITQALERAEAIKGINIKKKEFVGLEKKLDKSLSIDEESMVSISKSGHIVSGHDSYTKQEIKVLRKSSNINGIDYVPFLAQLDLKERFSTLSQFEDPNGLLKLSSKQKANFVGFRRLSEIAENPVIFSNSKHIDCFAIKQTIVTDCSFIASLTVAALYERRFGKKLISCIIFPQNRHGEPVYNPCGKYMIILHINGILRKVIIDDRLPMGHYGQLMCSYSQNKNEFWISLLEKAYMKVMGGYDFPGSNSNIDLHALTGWIPERMSLSECNKENFFSLISRRYNAGEALVTFATGDISDFESERTGLVSTHAYAMLDVKSVNDQRLFLLKNPWSHVRWKGKFSERDLGSWTTEMKRVLNYDPSSAKNFDNGVFWIDIDSLFKFFDVCYLSWNPALFKYVYCTHDIWNAGVGPAKDLYYMGDNPQYSLKIKNADSSTWIVLTRHIMDRDDFANNKEYIALLVYKNNGEKVILPFEPKPYIDGARINSPHYLCKIIVGKDNSELRYTLVISQYEKSSTILYSLRAYSTSPFSLKKIPNIYLYKEKEKNGKWTPETAGGCPNNPATYHNNPVYQFLLDGSSRDDDNEVMIELRGPKAYAVGLEVVTVSVMNPNSPNYFQRKHTGSFRSGCTYLRLKSIPTGTYQIIPSTFLPGQVGPFFLYVHSTHRVKLTKINMDSEMDNYEGEDPTEVYQKCVELMGSKDFIMEDSVMPTLKRFFHVKGTKDEAIHLLSTNYDAVAQIANLLAEWLLMTDLTLAEVQSTVEDNLKNMIIKHFDQKKADSIFLDESKGNPDWLTALIQHQPWRKLIFQLADKYPDCLMLTFTVKLISDAGFQSEITSISTASQQLEVFTRILKTSVTNFLEKGEEMLDSEKVLNEFAKLVSHGEHTYLYSQVLLHYLSLEQKGGSNVKRLFQEISRFAQKNGHNATPIMLSLMGISSHPRLSQALSAMLAKDALNPADITMLYKCYQETSPPPVEFLRIPQFLDLLLDALFKPGSKLHSDQRPKYVYLLAYASSVHETYRKHNNAYNNVQFRKSINRDELKPTIQAIEKVSSLCVERKGSSEILPELKTLYQMIEKYQVVAYGIVYWVKHVVSEPSYFKLNTEQTPLHLALLDEVTACHNTLHKITLNLYIDIFEKQYDELEVLAQLELKKMILDRMIHLISKGCVVPVLKYIKQCWQKGDTDISLFRYFIIEVLSMITAPYSIEFIDLFFPLVECEEVTGNMRSEVETTLVNEFIETCKNLKNEHRDHSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCW3</accession>
    <name>A0A922LCW3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCW3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="306" mass="33792" checksum="9E1FBAD70A4B46E2" modified="2023-02-22" version="1">MTSTTNMAITSDTQQQRNRQRRNQRKRHASSSSSSSTTATTTTTTATTTAAITLLNDSNIVEENDNDDDDDGQNSHCSSNTNDGCSHGSVASDDDECIPGDSDDVNDNLNNVDDDDIVPSSGICNNNSDTDDDDNDDEGSGDCENKQEIQLTVEQQQHISKDQDNHQMDTEDEDNDNDNDEILKSEITKKRSINTVMMNRRKLSTANRLNSRNNTVAASLQSLSSSRMMSTNQPSSTQRHQGNKNNGTRIRTKSLNNQQFIQNGGGNGNSSRKRKYSSMLGTRLANKMTTNTLLMPTQQQQQQQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDQ4</accession>
    <name>A0A922LDQ4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Px domain containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Sorting nexin-17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SNX17</name>
        <name evidence="7" type="ORF">DERF_003916</name>
        <name evidence="6" type="ORF">HUG17_5773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDQ4"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06885">
        <property type="entry name" value="PX_SNX17_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000145">
        <property type="entry name" value="Sorting nexin-17 isoform1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000008">
        <property type="entry name" value="Sorting nexin-17 isoform1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048763">
        <property type="entry name" value="SNX17-31_FERM_F1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048767">
        <property type="entry name" value="SNX17-31_FERM_F2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040842">
        <property type="entry name" value="SNX17/31_FERM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431:SF14">
        <property type="entry name" value="LD15323P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12431">
        <property type="entry name" value="SORTING NEXIN 17 AND 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21273">
        <property type="entry name" value="SNX17-27-31_F1_FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21271">
        <property type="entry name" value="SNX17-31_F2_FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18116">
        <property type="entry name" value="SNX17_FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="459"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7642726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9530080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="524" mass="60822" checksum="A5A6C148BDBFDA05" modified="2023-02-22" version="1">MHFSIPETKEIKNGFKTFITYLIYINGSFHCSLRYRQLYHFHIQLKKAFGANSLSDFPPKKFLPLNSLQIEERRSQLEKYIQIVSQDSQIINSDIFNGFLLAAQQESLNDIVGNDSIDVYQLDWQPVRLMTNGQENSENLLKKICQTIGMNAKYVPYFALYLVERFVRDDIVTNFRMIRRLQNFESPLLTLRTMMNKAADNHNKFVIIIRKSYFDIQFDQDLFDDAIALNCIYLQAVHDIENGHIICNNADTLKRLNHLKMNANKLEYIQLSRLQKFYGYLHFEPCLCDLPSLTPKTSVTMFAGNQELIIRANDTDQEYSFRVIRIKCWRLTTSNNHRNDSLTENESQDHPKEEKGRFELSFEYLINKGTLQWITIYSSQAVLISYCLQSMVEEMLLKREGKKFRSEGLAIRYNTSPNSRLANQNQMDQMNINTNGGGVNIANDSGFEWNYCKQDGSQFPLSTSSSTTTLTSEKSQNSEKSMNDTTEQQQQLKLNGITDPLSQRFQEISLVENDVFDEIGDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDR0</accession>
    <name>A0A922LDR0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_003968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDR0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9530140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="142" mass="15500" checksum="55423C84FE9E722C" modified="2023-02-22" version="1">MAANIIIKSSTIMHRKNKNNNDNGKMSTITSVVIMITLLANLTTFCHTMMYQTNSSPAPRMRIPLKVPVIKGRVPYLTLTSTKGQQIYSSLSSSTATNDAKSSSPQPSQLSSSSPTTTSTTSYQTYTETANIEQQHCFITAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HF82</accession>
    <name>A0A922HF82_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_015807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HF82"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9491071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6683" checksum="2507F61A459F4FCE" modified="2023-02-22" version="1">MIEQCSELLRIPDFDRSIVPTLWMPGNINAIGNENAGLICCNIVHDFGQKFSFEKIQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HHY2</accession>
    <name>A0A922HHY2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HHY2"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="420" mass="51046" checksum="FD6CAADFE0D1FFA0" modified="2023-02-22" version="1">MPFLDLKFIRKRINYHYFMIRMSIQSLTLPLPISSSSLRQFKRRKRWPTFNCLLFVAIFFIIILPLLLIYRLYWFRDFIYIIRPTFDHKVTFKNVITHYHLIDSGNDSTDDQLLCSFHGWIARNNRQPNIKVIDAFLFSLEFDLLEIRLRELWPVVDIFIAMEANRTFNGQSKPLWLREQQQFTKRFEWASEKLKIFNCPDLRPLESGQSPFVNEIRMRNCMTWTIRSLARTNDLIIVGDVDEIPRRETINLFRRCDGFPEIVHLQMKTFFYSFEFYYSSDDFWQAKLQTYDRKRFYYSHQKGSEHLLADSGWHCTFCFRYIRDFRFKMTSYSHNDRIMGRNYLLDDDEIQRRICNGLDIFDMYPEVYSFKELMQKFGPIPHMDSFIDIPATLLRYSKRFPFLLKGNCIRDDYRHRSSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLH0</accession>
    <name>A0A922HLH0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_014146</name>
        <name evidence="3" type="ORF">HUG17_4079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7640046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLH0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7640046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9493395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="322" mass="37275" checksum="1A405A46B97B186E" modified="2023-02-22" version="1">MSPEWMNKFLLKIFVIITNLSIILSSDLNINSSSSSSLTIETTTTAILSISGSIVERNQIQQEVRKRNFLPLYANIVERTKYSKQKSNDSTSINPLRPSRPQSFGYIWSILIATLIVATILVMTIMYAYRNISKDWRFNGNCNDGPLDDNDDDFDDDVNFTHSYRYSSSKMPMNNNLSGRKRDDNSLLMMRRLRFQFGNGLPCPQDNRQPQQQQRQRHLSNQQQNDTDTKTIKLNDTSEITTATMMMSTMNQNNNDEQPEPEQQHGQKTMDKMEKQQQPPPPPQLLVIPNGDDFYDQIIKNNHNHKHDINNNDHQIIIHHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLM0</accession>
    <name>A0A922HLM0_DERFA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLM0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="181" mass="21669" checksum="2B6F5D6A5BFAB02E" modified="2023-02-22" version="1">MADNKNLQIKYQTYGEHCRLLKQINKSIVDACKNDCLLAHLVPLLSACPNPDVKYNQMIRDHIDCRNSCRSIPITIRSYDNRIYNVFIDKKSMTNNTVSKDLLRISIERDMSIQCQMQARQERRYVKKFFLKINWKRLWQRYDLIIVGQQQHQNRINLRDNNSNEQLELYDNCCMEFISKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLZ3</accession>
    <name>A0A922HLZ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_016059</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLZ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.2010:FF:000001">
        <property type="entry name" value="NGFI-A-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.2010">
        <property type="entry name" value="NAB conserved domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006989">
        <property type="entry name" value="NAB_co-repressor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039040">
        <property type="entry name" value="NAB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006988">
        <property type="entry name" value="Nab_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038398">
        <property type="entry name" value="NCD2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12623">
        <property type="entry name" value="NGFI-A BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12623:SF10">
        <property type="entry name" value="NGFI-A-BINDING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04905">
        <property type="entry name" value="NCD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04904">
        <property type="entry name" value="SAM_NCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Nab N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="NAB co-repressor" evidence="9">
        <location>
            <begin position="219"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="479"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="663"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="881"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="483"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="559"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="883"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9491331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="916" mass="102290" checksum="82AB297C19F518CB" modified="2023-02-22" version="1">MTTQPSNESELQLYRVLQRANLLAYYDTFICQGGDDVQQLYEAGEEEFLEIMALVGMAAKPLHVRRLQKALHEWATNPALFQSPLVPSFHSNNNNNTNNMAPSSSIVQPSITGQSNTSAAISTRTLNNGPNGQSQPQPQQQPPPPPSSSSSSSTTINNAQSISSPNAHRNHNNNSPAANGSSFQTRSTTGNQSTTPSPSQFQNTEYSQPCSPSSMTPILMERQIRRLAEAAEQLVKNLPASILDLKPTIGNNTNGNKKRIVKEIENIMSMSDDDPRRIDEIRRYAAIYGRFDCKRKPEKPLTLHEVSVNEAAAQICSKIPQLLYRRDELFPLARQVVRDSGYQYSKGHSRSQSCRIGEDPSSTGNTIGSIKRIRLDNNGNNGGSSNSSRSSPAQGQQQQQNQQQQESKNMSKEYEEDRKRRHNRLEGIVDQLKSLGNQQEKIQSQIKEANDRQNFQQVNELQNELEMINDHQMQLVNEKSELEQQQQQQQKQNETKQQQQDTSQDGQKCNRNNSKQSMTEMIETKTETDDTDSQFSLYSNESMPSSLLHESRGHDDSPSLSNDNLATNSNNNNNNTINDDSTDVAVSNNEKIANRKKTNGLQTTTTPPSSASMMINANSNDSMDFGKQLNDVIDEGLRLMGHVIDENIDLRLFNKYTEVLRNNNNNNGQSSSSSHDINNCNNYRSPKNEQPIGVTTPPPQPPPIMTSTPHNSIHNHPHHQQQQQHHRQRGRPPKNTHPSMNTTTTNSMNERIDLSNTFYEQLLSQAQIQQQMQLYQQSLYAQALFGDFNNSATTLSNTTDNVSTTTLMADQSKTDHHAHHHHNDDNNNGKNNLIDNIQIDRDEIVQSLNALISISSNGIGHHQHHHHHHRQQTLSSTIDGALSSTQSSNSNHPTTTTTSSSSSSSSSSSSVEFKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMK6</accession>
    <name>A0A922HMK6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMK6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="35" mass="3747" checksum="AC729ADAC648479B" modified="2023-02-22" version="1">MCDANIVDTKIICLQARMSSTNSNGSVFLGTKDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNL9</accession>
    <name>A0A922HNL9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNL9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="79" mass="9302" checksum="680D77B5C3CE1C5E" modified="2023-02-22" version="1">MKFAKINKLKIEISDDDDNDNWKKVMCDNYECHKKSSSSSSFEFSNRRKKQVDACIVNWWVTIFNGNCHHNKASQSEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPD7</accession>
    <name>A0A922HPD7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LEM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ANKLE1_7</name>
        <name evidence="1" type="ORF">DERF_014564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPD7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034998">
        <property type="entry name" value="ANKLE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46427">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46427:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22945">
        <property type="entry name" value="LEM-3_GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="267" mass="31376" checksum="D19A1DBAED6728B1" modified="2023-02-22" version="1">MHQDQLDLKHQMKEITIMNTINVKNETTHFLHSYNFESCIREYIKHIIKPLRHFCPTNITDSEHTIHNISTDIFKTNSFSFDEARRLEREMLSQCSSSWLEKRNLIVYFLIDPSMLKNLPPKKDSSLESELIDPHFFFQFISSIFYVGCGLIDRPDSHFLQALNERMNPTNLDPSPKIQRIFSLMDRFIEPTIYHAQENLSKQESFMYEAIIIETISLKNLTNKTCGNNLKKLNMNTRQRKVLGTYLMCEIFKKYGSKFGLTVFAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQK6</accession>
    <name>A0A922HQK6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQK6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6629" checksum="94D781302E5DD5C0" modified="2023-02-22" version="1">MDDHEISKSVLRLLVIGDVDEYCGGLVRLDGLSRRYANLGFDGIVLNGVVVIHVESDAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRQ3</accession>
    <name>A0A922HRQ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Globin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_012220</name>
        <name evidence="3" type="ORF">HUG17_8996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the globin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRQ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="2">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7637892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9501366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="173" mass="21153" checksum="63DF673854C66EF1" modified="2023-02-22" version="1">MQMMNNTFEEFNEEELQSLRIQWDKIVHYRHECFGLKLFLRLLDLHPEYLCLFGFTWDEFDYHETARLRAHGINVMYMLNMLFDNLNDMDMIDELICKLIRLHLMRGIQKSWFDDICEPFETVLREFSQKLNIEHPEFIRKAFMFVKNRMQLLYDDNMAQVLLDQSSDISETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRR2</accession>
    <name>A0A922HRR2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="14">1.8.5.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Sulfide quinone oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DERF_012230</name>
        <name evidence="18" type="ORF">HUG17_9004</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol</text>
            <dbReference type="Rhea" id="RHEA:55156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.8.5.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:55157"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10</text>
            <dbReference type="Rhea" id="RHEA:62608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:62609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate</text>
            <dbReference type="Rhea" id="RHEA:38359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="ChEBI" id="CHEBI:46245"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:38360"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SQRD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.8" evidence="14"/>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRR2"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106436">
        <property type="term" value="F:glutathione-dependent sulfide quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000034">
        <property type="entry name" value="sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="17">
        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7637900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9501381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="454" mass="51406" checksum="B22AEACE062F7DD3" modified="2023-02-22" version="1">MFSNRILIVDRIFMRTMATMPVDMPKKSYELVIVGGGAGGLAIASRFVRYFRAMKRPSNSIAVIEPRNTHFYQPYWTLVGAGLKDLSASGRPMAQVMPNGVDWIKETCSGIDPKSNNVMLTGATGTVNYRYLVLAAGIHIDWDKIEGLLPALEEPNNGVCSNYSDSFVTKTWKTLQQFQGGNAIFTFPNTPIKCAGAPQKIMYLTDAYLRQKGVRDQTKIAYFTSLPIIFAAKHYAKSLMELCRQRDLNVTVRHNLVRVDMKKRLAYFENLDRPDDPLLKVKYDMLHAVPPMSAPKFLKSLANNTSNGYVAVDPKTLQHVEHENIFALGDCSSLPTSKTAAAIASQNSILAKNLLQFIQYKDSDHVDGIKINFKSNYDGYTSCPIVTGNNRCIMAEFDYQLQPLETFPFNQSKERRMMFYVKKYMLPFVYWNGMLKGYWSGPSIFRKLIHFGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS98</accession>
    <name>A0A922HS98_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS98"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037241479" evidence="2">
        <location>
            <begin position="28"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="826" mass="92905" checksum="FD7439F710BAE63B" modified="2023-02-22" version="1">MKLEFIPISNILVFAAIILHICCGNDAQNIKSHTIVDNNRYDGPSSPVFFHRQRAMASFQVSDQPSNQQPEFGYRLRMPSQANPKTYMDYNQNTNVDLMSVKPRPIIINRGEQQLPLDSSPSSSEQIRPSEYSRHYDEQQREQPEPLEQSTFTGSNDNNFYGVPQPSSSSSLSGNVSQPHESELHTTPNPVPTTEPGIVYYDFNDENQQQVQKQQIPQPQTTTSRSSSGEHSDQRQIEWILPQQQIIPASQIPVGTPVIFHPNGPQPVPEAGRPGGVGRNQFVQIPRPGGPLQSQHLNVPINQFQQVEIPQQRVAVVPANVATPQQPSLVIIPQQQQRYFRFQLPRQQDVADTSYVREIRPMPMNFPITQIHYLQPTIPERMNYIIMIPQMKIVSPVIRIGSTGNTAQQPTNVVGYKSVSEPVNQTAVGYNYQVTQEKPVVTQTRIHTPVFVTDFKPSKGFKYTVTRDDQPTVEQQQHHHGEQSMVSIPVAQQPIDSRPAAAGGGDRFYQVPIPTAQPSAQPIRHFYVPPYMHPFPIDNIMRPPMYYSNENSLSDYKRASPGETHTLPVVSNQPAQGGPVTITIEPIPQETPSTGSRSSQPIVSEPAPAQSTVIQSKPINLVIDKKNKNSGQPLRQAVFEPIKNVAYLSDYPEFDSHGQPKQQQPITQIGHSLRQPNTYEPPNEYQNQIGQPLRQTGQKYGHSPQHASDSFVSSGQPLSETDNYLPIYGPPSIQNYQHQQSSAIADESSELEPGHPDYITGRGHQLNSIHNPQQYLYAPSLPQQQQQSSVNTQWPVQQKIDNNREYYQQSIDDGHHQYHHQTSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSN2</accession>
    <name>A0A922HSN2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_012670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSN2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20821">
        <property type="entry name" value="C1_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="780"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="842"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="102"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="318"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="474"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="626"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="719"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="856"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="887"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9501861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="924" mass="107981" checksum="427D4728467F1A8D" modified="2023-02-22" version="1">MVHPIKSSCRLSKEFNKELDELIEYANKFEQQQNDMNEEMKRLQNEFADRERMHLDQKQKCINECRSIETEAMVLMEELKSVYEEKIDSIKKHYEKQFMLMIQKHKSEIQTWRIKYESIEKTIKSSSSSKETVKNEKIDQQQEQKFKAEIKRLEERNDELERENKHLKTRVETSENRIEQNEAQRKTIENDLRKSKHECNDRNEEIRKQKLKITELEKAIDKQKRQSDEKESKISELRKKNEKLEKEVAEMATPIKSTSSTTSTAEIILPHGKMMDENFTSGYGGLYSSSDNDNDDVQTLKSKLIISERDMRAVNRKLENKTEICNILRTELSEIKQKLTDYEKSLVDEKKRSNGYSEMVSTYRSELDQNKQEIERKDTEIVNLKCLVDENNNNFNLKLKVNANANNFFDDQQNSNSAITATTSGSSNQPSNMESSENERKLRSKTGELTRRIDTLMKEVETCKRKNADLHYLVDKTTNNLNHSNNENEQLKNKIEKYRKLLKCCEEQLDQYNIKFPTLLHQQKSQSSDAISVLNSQLMELKKKNETLRNELEELQAKLIEQQKQTEMIVENEKMENNRLQRQLMIEQSKTERLEHEMNGQQDIFDNREQELVAIKEEAAGHITKISQISKERLELEAKCESMANDIELLNERLQLLNNNLEQKSEEIYRHEETISQQLKLIDFIQSNCKCLEKKKPFMLFSFGSKLINSNQSSTKSLTEELERKLKNEREKNNFLNVRLNEMINELDERTSYVEKLRKEVRKLETQLKTKSYFEQMGGEHNFTSKTIKLSDICVACAKSITIGSKAKICKNCGATIHNGCRLSYNCGLSLEMVRLKSFGLGMTPNQRPEHQNRPYDSSSNDYNDDNASSMLDDNDNGSIITFLPGTTTTNTNTTTTDESDINSINSFPHHMMEEPSAPEHSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTF0</accession>
    <name>A0A922HTF0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exosome RNA helicase MTR4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SKIV2L2_12</name>
        <name evidence="7" type="ORF">DERF_009148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTF0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="499"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="703"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9510632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="927" mass="106931" checksum="BDAC660BBEDFCAF1" modified="2023-02-22" version="1">MIRKNVKVDNNSNSVWICHFLDSELVVLGWICHFLDFELIVFKTNAKLSKLMLIEVNNDSLIDLISENQSEVVDINSFVKVGEKQQEKVDEKVNEKSYDLIGVRTNDVIDNKSGVVTGTGEHNMNDCDDLTWDCTSFEYYRNRFKRRMLQQIVLRSNHINWKRTGLQNCNNIELNFSSIISLTCNNAIMTIMQSPLVGLINSLLLSKNFIFTARTTPSELLIASVILAIGQSFRLRNSEGTKTKSFIFISVEDPIKMATELHSDHHFFAQLEYHLQLRQLNFSSIISLTCNNAIMTIMQSFLNTKSLAPDKHENVRDHYWHKGSVEINILLNDLCFEMDLFDVFDLDQKSNDIEKSNDNGEKKLMTTDEDVDNGLIDKSIKDVKRNKDNDENLLITSMIDEWTITPDDTDDHDDENLGQYYANFTARVAIHKLETQGSCVHEVVIHDDLEYVPLRDHSGNPIYMPAKSYKFPLDSFQKEAILCIENNQSVLVSAHTSAALSNQKYREFKDEFEDVGLITGDVTINQNATCLIMTTEILRLMLFRRKEIIRQVGWVIFDEIHYMRDRERGVIWEETIILLPDTVHYVFLSATIPNARQFAEWIAYLHHQSCHIVYTDFRPTPLKHYIYPAGGGGDELYLVLDEQNNFSEENFNTAMNVLKNSSSKVVDPSCIKIIPIIMKRNLAPVILFCFSRKQCERYALEISILNLDYNSAEEKTLVEEVFNNATDKLSDEDKKLPQVQQILPLLKRGVGIHHSGLLPLIKEMIEILFGKSLIKVLFATETIGMGLNMPARTVVFTSVRKFDGRNSRFLTSSEYIQMSGRAGRRGFDERGIVICQIDKKNSPILVEQMICGKPETLNSAFHLTYNMVLNLSLFFQFQQYLEYHKLDENLSHYYKEFLNIGKQIEFFEEELCRNEKKNKNHKHNSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU66</accession>
    <name>A0A922HU66_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_011047</name>
        <name evidence="2" type="ORF">HUG17_5842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU66"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276913" evidence="1">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7643480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7256" checksum="227733AB22155C17" modified="2023-02-22" version="1">MFVMWLIYCYWSINIINMNANGGDQDDDMTFVVCDSDTIIINGRDLLTSNGSSNYILDLELGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU82</accession>
    <name>A0A922HU82_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU82"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8317" checksum="B49705AF70491EED" modified="2023-02-22" version="1">MDQATAAADNVNAIDNDDNVDDVDDDVIMMNVWGPIECHDRNVSNVEENENLKVSMTHFFVVVVVLGFFFIDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUQ7</accession>
    <name>A0A922HUQ7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUQ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="330" mass="38867" checksum="6B8E5B70EFEE3048" modified="2023-02-22" version="1">MKSSSADCVVDKTNNHCTNRSNSLGRQTNASIIGRLFTGVEPINIAKIRRRLFSFHQRDAFRSDLVQSLPTKLNESRNMIPNQDSKIAKILHFNNIKNQEKRLMISRNFSHQNWHHHDMCKNQDKLKTNNSHKNLQSTSTNNSEKLRPHKHGCTMIPFQRQMSFDVDDEDKDQDKIKKCFHHQNSHFKHSMKTSINESLIHNMPNTQVYHHCYSLCQHQHHHHKQRQQKRNNPFDDSHYVDYNSNCINCFNDDKTVDDIYSFNKSLNNDKKNSLKRENNCNHCRDRHSLCDKNIRNDVIARNINDDDVDNNRKSNDEKSDGNDKSETFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV54</accession>
    <name>A0A922HV54_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009999</name>
        <name evidence="2" type="ORF">HUG17_0059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV54"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324685" evidence="1">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7644521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="166" mass="19198" checksum="202947A54F49BA80" modified="2023-02-22" version="1">MSSKFINHFFIGSILMTMLISMLMLSTQVQAQESFEPDSEPVRPQLPDGTRRRYDRFNQWMKVINEFFTQGNWLNGGPSNLIEYITSTLAKLLDILMNRRGPPVIAPVEPISPPSTDDTIEYKVLDSNGRQRQSIDRYRESIGNRPKIQLNLNDIIRMIPTNQLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVF7</accession>
    <name>A0A922HVF7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.258</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ALG3_1</name>
        <name evidence="13" type="ORF">DERF_010648</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVF7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="355"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9505877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="511" mass="60468" checksum="4E3EDEDA3F15DB50" modified="2023-02-22" version="1">MGPIRNKSSSSSSSSSSSINRHNNNNHMMMMGQSFISNIKHLANELQDFIQKKIFTFKIFHEQQCYPIVSLLLLLFEIFLNVIIIQRVRYTEIDWSTYMQQVECFLNGTRDYSQITGATGPIVYPAGHIYVYTLLYWLTDYGHNIYRAQYIFASLYLITLFIVFRLYRQYSMAPPYVLLFMCLTSYRVHSIYVLRLFNDTVAILLLYLSLLSFTSGHKWIRGSILYSLAVSIKMNILLFAPGLFLLYNEYLNTWNVIKNLMICALVQIILAVPFIVTYPISYIKNSFNLGRIFLHKWTVNYRFMSEQIFIHKGFHSILLILHITILFIIFHQRWMNLIKKKIFSFNKNNFDNNEMNEQQQQQRRQQQQKQRQNFHHHDQHPDNGTKQKFGQHILMTMFISNFIGIVFARSLHYQFYIWYYHSLPFLLWTTSNGSSHSMTNICMLGLIELVWNIYPSTIWSSIILHLVHLTILYRLIRWSNIDIVVEMTTTKTMTTTTITTGTINNDDNKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVH2</accession>
    <name>A0A922HVH2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_009626</name>
        <name evidence="3" type="ORF">HUG17_7478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVH2"/>
    <dbReference type="OrthoDB" id="1149618at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058580">
        <property type="entry name" value="DUF2828"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056690">
        <property type="entry name" value="DUF7788"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011205">
        <property type="entry name" value="UCP015417_vWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373">
        <property type="entry name" value="OS06G0652100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373:SF27">
        <property type="entry name" value="TROVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11443">
        <property type="entry name" value="DUF2828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25043">
        <property type="entry name" value="DUF7788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015417">
        <property type="entry name" value="T31B5_30_vWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2828" evidence="1">
        <location>
            <begin position="6"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7788" evidence="2">
        <location>
            <begin position="450"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7637272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9511155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="657" mass="76968" checksum="EE24FE1AD4BD804F" modified="2023-02-22" version="1">MSLTLTENFSLTFDSSSDARLDFFFHVIEGSSSERTTELLEKSWSQSPLDTMKMIINCRDIRGGKGIRPQALICLQWLYKNQYDNLLLNLAHFDEFGCWKDYLNLLLIALFDVLPHDVDTSDKKTKKYHTHVNRFDTVILRSFPKIKRQELEMIPTVVRQVERKFIVNDESQKKIVRQIITERNLDGKKFEYKQVNKYFPQKNPDAKKFFYKFKTDKAKLKKLNEYRREYFNKIYENDTKFRQLYDRIVDLFAQQLAKDYGYLKEENFNKISLTSKWLPNRNRFFDKYFFILGPVAKKFFELQPEILIEIQSTKRNDEKQMIILLSRICTKLRRQIQVSEIFMSSKSWETIDYKHVPSVAMLLYRQAFIRNDHERFNEFIGSKSLNAGALTPADLVKQVMDGTILGVDLFNADIPENLDEQKLTSLKAIDNQWRSLVNNVRANGSLLATNTLAVCDVSGSMCYTPQAIKPIHGAIGLTLFLMEIADKAWNNRCISFSETPSFHQIDMTKPLVERCKQMVKCSWGMNTDLNLVFDLILNYGKENKLTSEQMPKILFIFTDMEFDCAIREKTNYESFKIQYELAGYRTPFIIFWNLKGEKTSKSTPVKYNQDGVLLLSGFSAQTFKFLFSVKDFSEITPLVMLLKIINDPRYDCIKVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVJ4</accession>
    <name>A0A922HVJ4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_011121</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016589">
        <property type="term" value="C:NURF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15559">
        <property type="entry name" value="PHD1_BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15560">
        <property type="entry name" value="PHD2_3_BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038028">
        <property type="entry name" value="BPTF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45975:SF2">
        <property type="entry name" value="NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DDT" evidence="14">
        <location>
            <begin position="197"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="349"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="2127"/>
            <end position="2177"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="2255"/>
            <end position="2306"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="2333"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="886"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1241"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1362"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1830"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2046"/>
            <end position="2101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2182"/>
            <end position="2244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="905"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1366"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1843"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1863"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1901"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2054"/>
            <end position="2066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2083"/>
            <end position="2101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="2188"/>
            <end position="2218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="2219"/>
            <end position="2232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9506383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2422" mass="274437" checksum="A996BDF7FBDD9B2B" modified="2023-02-22" version="1">MRKSRPRKRGRPPKNQSNNNNKYLNTKINKVIIDDDDDEDSNHSSSTTNTSRSSGTNNKYQTRSTRRSSTRSSSTVVELTKKRGRKRKKTESEDELCDDEYYYDEPATQSDEDVDDSDKDDDDDDDDDVDVDDDKDDENEIDEFEEEEELEEESEEEEGTEQTGKRRGRPPREKAPVYLDDQEVPELSLPSSSEDLLITGNELILFMKFYDTFSNTLRLSPFRFEDFCISLLIDEQTYLLSEIHIQLLKALIREDDLIGTQHGPQDIRDSINVYLHLCDHVTWPEVLKIYLSSDYKKNKPIMDQSLMNDTYPFTSVDKKLILLQHLCDDFLNTQVVRDAINSEGKLDHDEHCRSCHKNGEMLMCDSCPAVFHLSCLDPPLKQVPEQEWFCPICKQNQVMGVTDCVNEYERQMPRQEPIGWDRHGRQYWFLARRIIVEDTKSDKVWYYTTRLQFDELLECIDDEMYESDLCKTLSELHDDIYKQMGITEKLTKIAKGSRKSYLEVVNEELYLKRSSKIKSNSTDDQSVIGEKIAELETKLAVDEEDLRGAGAGGGGMQTRLKTGTLPQKSFTMTTNYLRNQTSLYNTIQAFRDEETVIVVADNEKTLTRTQRRALPATYFEVNLFNLGFEGNYRNYQNIYSLIPMALSRNQVQDDRDRRRHLSHKFSLTPMSDLKWASYNQVITAAPVTTAHGPKPMLINTLRQALLQFELNFPNPLMHSNWKRHRDNWIKAVKICSEPREFGLALYILESSMKPVLFNNAWNDLLGFTVLQRTTQLERDELKKKEKKSGRSAAAAASAMAIEVAELMSSMLDPNDSSTASKYNPLGGGAGVKLVNGKLRHQIWKQKGEEYRLSGVGGWFWLTSIRNPYKVVKCDLEKNLSLTPNVDDDVVMKESESDDNNNNQNEEIKTEKIDENSTMKTDDDDDDGNDENFIVKISEFLTEKTSKKRKFYYPKIFQESRLDKLLSCRMNQLTFERKQKKENDDVDDEKKNDVLIKPLKSTQPPVSITSCCYSISCDSNSSTVLPSSCSSPVENGHHNCYSPLCSYLAKNQNLINGNCCSSIKKEEMIFKDLTESVELQKIITVDDVEQFAKKVVSFTSKAQLPPSTRFTNGKFKSIFIPLDYELRQLGRTGGQYEISGFNYNAKINPSIWPYGLTPRPSFRITWLFRVYNLPTLHCVALQLRVLWASVRWDDLAQKPPISGTNTITTDVDVQTIEILKRRDMPPFGKITVPIDVPIYRSREIPTPNRSGLRERRRPESPQNRGPRMDENWVREEELEIWEIKQFNDKQIHLARQKAIQEQRQKELEMKRKLQETGSVHNKTSIDTVRFVNGGNINLHPNTATSFGKTLTAKFSTLITNRVSPKCSNTSSNSSTQSTTHHPTIATLNTSLPYGSTIHTSNGQAIRLQTTNVTKPSSSQLFIRDGNNFQLLTSTASPVTANNRTYILRTPLNSTGGGSTVTTNTTTTTTTGRPIFISNNFNTTTSPIIRSVNTIQHSNIRHSIPIIATNCPKKISTATTVNAILTTNTLKNVITTTTATTVTTTATVTATATSSSSSSSSSPVLSAINVTNSKNITCLPLKLSDGRTHYLPLSSLSTAAASASGTGTASGGGVGTNQTVQISLNSNNQIRFITTKPIINASNSPSAVGLRSNNSTIVTGGGGDNNNNNQSQSQPKAIFVATSGNNAMLAPTTTPLNTIVLTNANNQKVILHSAATSAATATPTTLNQMGIKTIQIGGGNNQSTARILTKSPIIVRNPNVVTTGQQTDPIPASTLSKANVINSNTSSSNLQNKESEEKDFVVTAEMTQDIVRKALMNPNVAPEIAQKLLALQKHHQEQADSPNYQQQFNQQHQQQSLPNKNEYTTSNHRISQRSSSLSTTTRSSRYSRSKYDNDGDYIYEYPQPERHSRTPRPVRDEKEDTERICSNVIKQMIDKIEKEIRSNKHKEVMAERKHKKNMQMKIKFRQNHIEVIRRNILRRKSVFNQHIKCMVEREIDEKLKQAQRKLAAAHAKSSLVKTASSSSSNQTVTTVNQSNNVKLTISGVKHKLDSKDFDSNNKSNNNSSSTETPESESRSIKRQRLANTSGSKSSSSPSSSSNVDSQSTVNNVAAAKSPHHQTQKKSPKSKTATNYCICNRTDDKSMMIACDDCGRWYHIKCIGMDKQEADDLEQYFCLDCKDRNPKLNDDQSKKSNSLSNNNSKSSPRSTTVTTTPTTTNVRKSGPGRKPKHHHHHNRSTATNNNSNDNHKVVIEHEDDDKEYCFCKEKYESEKFYICCDQCNDWFHGRCVGVTCIRADQIDEYFCPRCQGEESRSYRNIQPLVDGDFQRMEKIVKTVKSHRSSWPFLKPVDGKQVPDYYTVIKEPMDLQQISNRISGRNYKRFTEFIYDMHKIFDNCRYYNEPSSQYCFFANTLEEVFERKLRELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVU0</accession>
    <name>A0A922HVU0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVU0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="620" mass="70983" checksum="DB2CD32B6CA211D7" modified="2023-02-22" version="1">MNKNGKKGKRQNPTSSSPSSSSSKRRQKQSTKIVTKSDDDLPSWRSESFSDIPKSYDSPSFSHTEKPMSKISPLIKTKKEKSITSKSLSMKNNRKPVTTKLRPIISKTKLKHGDKKRDTQPLSPSSKTKQIKKKNKDTNKIKELKVKTITKKEKISETKIIPKSVYEKAISKQVKRLTTRSELNAIANLCLKLMRYTPKSNNDSMEKRTKLYQSPLIKGYQIVEATTTTEPGKITEAIKRDITTLKIHITETVPKQIPEDVTKVQNLEQTMTEELPKIIWQLKDEEKQLKVFDPFGERTSLYYHRLEDYGNLKELDTSSGGLAIRYNPYLDCRPIYQQYDQQNLDSIIEIIPGLINDEMEETYITPISIVDLRKRSPPSLEPVSSYIQPTFKWIVAPTMVDTTNSINVIYDDDIGKKEGTQMSAFGERDSLFYRSPYSYPIYDHYDDIKISFNPYIRGTSFYKYYNLGELDTMIEIIPGTSNNHYDDDIDGVVGGVCVAGRKINYFQQSLTKFQNTTTTPKVFQPMMVPRKPPPLPPPQQQQKQQYQSLGKIIFKDIEKKFTSPMKQSPPFKSPSPLSTMMKNKTETSTNEVMTVEIIIEPLESKQLSSTSTTKDTLKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW22</accession>
    <name>A0A922HW22_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW22"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="52" mass="6061" checksum="B666B16678D695AB" modified="2023-02-22" version="1" fragment="single">MIKPQTDINVQQMDNFGPQTQKTSSLSKIDIDNDNEKVQCEYTEHHQLINEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW96</accession>
    <name>A0A922HW96_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">SH3 domain-binding protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SH3BP5L_1</name>
        <name evidence="6" type="ORF">DERF_010507</name>
        <name evidence="5" type="ORF">HUG17_9856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW96"/>
    <dbReference type="OrthoDB" id="446789at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007940">
        <property type="entry name" value="SH3BP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423:SF1">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05276">
        <property type="entry name" value="SH3BP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="108"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="236"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7643165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9512102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="401" mass="46583" checksum="744675770E5D2ED7" modified="2023-02-22" version="1">MHDLNDYDLKSSSSSTTTTKISTTAISKSSIIINNDKLIDGMDPDPRVQVELENLNTSTEFINKLELELEKARLEFNDLLAESAVKIESLSKKLGTSIHKARPYYEARQTANELHQKAQKEALRYEQATVEHNNAKEIVQLAEQTLRQNGDIELEQLLTKSAEKVNQSELERQAAEKQHRFTSREYSLTEQNLSKLHNQLKRSIVKASMETRRNFLELNNYANQHRLQLLPYFEMKAQFNQMLEEQVNKIRSYETRVNKAKQNYTKALQRLEELNNKIYDQRLPPTDGVQNLADNHNDDDGGGGNHYNEIVEETKTNIEKNINNEDEQKYLKPSNKSNQEYHDETIFDNEILDQLILEDDLDDNLNRLKIECLNLDHHHHQQQQQQVAQKSKETSSSSFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWI2</accession>
    <name>A0A922HWI2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Thromboxane-A synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TBXAS1_6</name>
        <name evidence="15" type="ORF">DERF_009242</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWI2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050476">
        <property type="entry name" value="Insect_CytP450_Detox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24292:SF102">
        <property type="entry name" value="CYTOCHROME P450 FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9510733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="543" mass="62870" checksum="20A07F739468664C" modified="2023-02-22" version="1">MIGTIIFVLILLITFYVIRKHRMSILKRNGIHGPEPNLIAGNIFSLLKKSNFERSQELIEKYGKTSGYYVGAKPNVMTIDLELIKRFQIKDFDKFSDRQTFGLKHGIRPNPRFSENVIGSRGARWKEHRTILNPTFSAMKLKMVTPIIESAIDIFINKVDKHSKNGNEFNIYEDFQLLTADVISKTAFGIDTNVQYDPKNEFFLAAKMVFDTKPSRFILLFTCFPELDILMYPFRRLLEIIREARGKSASAILSKLIEAAIRLRKDRPVKTPDLLQLMLDAQASDDELKQKDMSNLTIEMSNDEMNAVTEKNGTLNMGEKFKNSKSLTQDEVIANAIIFYEAGYETTSTTLGFIAHFLVTRQDIQDKVRQEVNELFKREGKFDYNTVNKLAYMQCVINESMRFYPPVTNFITRNTKEDYHYKDMIIPKDSTIRIPTYQLHHCEEYWPNPEVFDPERFRDKKNYDSVAFQGFGNGPRNCIGMRFALYEIKLALAKLLFRYKLVPGPSTENELTIEQKIITETPKYGVFVKAVPLLNNKIIFEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXV4</accession>
    <name>A0A922HXV4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXV4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9199" checksum="563C325FC1E18762" modified="2023-02-22" version="1">MYLFIRSSAPNFKYLNSLAFALHLLNGQNWSQSIPFNSIPFRLQPISAQVNGLHKSNNKLLVCQIAGNLPHKNGNKTTKTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYI2</accession>
    <name>A0A922HYI2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="4">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SMPD1_4</name>
        <name evidence="9" type="ORF">DERF_009698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a sphingomyelin + H2O = phosphocholine + an N-acylsphing-4-enine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19253"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17636"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYI2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037656898" description="Sphingomyelin phosphodiesterase" evidence="7">
        <location>
            <begin position="29"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="209"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="88"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="91"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="230"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9511227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="630" mass="72867" checksum="2968446C300E3213" modified="2023-02-22" version="1">MMTMTMKSNSILLLFCVAILATILTCSSSSPCHRISQKDRELIQTMLPPDNGQQFLEIYEENYDILAGLDINSIFAIINGNKPTLETCEACDSVLKLGQALPDNEQSLEFLKSFACKDFNETTPSITGRECIGLIDRLGPAILYILHNTKVPLDEGCSVLIGYECSKFLNRSYSEWTFWELPMPRQRQQQQQQFKLAQIDDNGGEKNRKILHLTDIHLDLFYTKGSNSKCNEPLCCRSTSYVVNNKSYPAGYWGEMNGDCDIPLELVSDSIRQIREQHPDIDMIFWTGDNVPHDVWNTSKTMVIEHNKIVANLIKETFAGVPVLPALGNHEAHPINMYVPIEVSEKNDNNHSMDWLYNIMADEIWSEWLTEENRMTFKKGGYYSRMINNDWKVIVLNSNAGYRANFWRAYNPIDPDNQLRWLMQELDHAERTGAFVSILGHIPPSDMYEGWLHNYIMIFDRYSHIITGAYNGHTHNDELAVMYNMQGRPIAINYISGSLTTFSFLNPSYKIFEMNPQGKPLNFDVFFMDLDHENRIVAHNNHSKPKDYQPKWLHEFDAIDSYQMKNLSPEEWAKWVDNAITDLDMAYIYSQHYHRHSRLFPDVKDLTLDHIIELVKSIKTISPFSKLQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZJ6</accession>
    <name>A0A922HZJ6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZJ6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="918" mass="100981" checksum="2DB9C6FBEA9ECD44" modified="2023-02-22" version="1">MDFKLKIYESLKIDYGDCLINLCGGGGGEYVPRTRDQYGLIECTAKNSIGIQREPCQFLIVPSANPYFPYQCLVSNQSDSTLSIRCDGSFLSGNISYSTTESSSISDNNNKHYDATSWLSSQQQQQHGNNISDDELDELNSEIDASYTGSGGDDDDDITSSTTKLKYIHNSYKNQRPEQISDSVASLLSNLTTSDIYAMYFAPDLQPQTAVTGNNMNNNDGTSNMPNTDQDGQSIKVTYRNGVGPFPANGPQRAAAASMLFLNELVTKFNSHPLNLQPHLLVYPPTYYICEIYSLSPKPTLIKNLTIDAIGKRIMNPLLNGSFSFLVDELPSNTPLRVNIYAQNNRKRSIMQVELDAKTLRAAERRIDYEGHQGQHAARGRKSYSTFFEELYGGYGRFRNKHMVVGLMISTVAITVIIAIILITIAILRSRHHQQQQNPSLFNHRQGQNENSTTNHSKGRTQQTMVNENEQICHNTNELIMLGDKLIHIQKQKQLQQMPATNNNDSLTVGNKNSGSLKRKNQQQQQQQRLSRSNQSLNNNHVLETTFLTSETNFDDDDDGHHHHHHHHHDVVMDGNHIRNNQMDLVEFANANSVGGGANGYGMDLIGADDDSSMRSDHQLIQSTNDSDKYYKSILTTKRTATATQNAAPPNYYDLNLTETSASSESTTAAATATAYVNILPSGAAAAPPDIIQNVMYQPTSTSHHHHHHAQEFFDTISFGQSNNNATSTTNNGSTSTDQLSGNIIQLPPLRKYSIDNSAIGVGSGSNGNRSIIISTDQQQQIIYGQQSSLQPNSASTILSTGNSGSSVSRTSTLLRHSGAYYNGSASGSGGHHSQYSDNSAAHLFGTLPRNGSPSSQTQQQQQSYIYIPSQQTQPQSTQQHHHHLIISSSAIGYSSPTTTTTTTMATSKVVNTSNNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZM7</accession>
    <name>A0A922HZM7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Akirin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">AKIRIN2</name>
        <name evidence="6" type="ORF">DERF_007009</name>
        <name evidence="5" type="ORF">HUG17_1508</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the akirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZM7"/>
    <dbReference type="OrthoDB" id="10039914at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045089">
        <property type="term" value="P:positive regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024132">
        <property type="entry name" value="Akirin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13293:SF6">
        <property type="entry name" value="AKIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7645970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9516255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="327" mass="36526" checksum="230C30F7E8381CE5" modified="2023-02-22" version="1">MACVTLKRPLEWIDPSMSPESGSSSPTHMIISNSPPHHGLRSPKRLCLQSLSQSPSTSAITSSSYSNTFNTFMPHQTCHFSSSSTSPFANNFSTANANQQPNSGNNYNFKRIISSDLADQIREEVLRLRLVRRKIAKVSAIGNKLQESSLSGSSLQQQDTKAIRNNVATDKQHQQHSSSSSANTSTSSTHHAAYSLYASLIDAANHHNEQEQHDVQIAKYKDGNLSSTTHNSDNNPDDDDDGNENRKKSSSASKSLASINNNEPLFTFNHVVLIVERILREKEESIRREYDAILSQRLADQYDQFVKFSYDQIQRRFDSQSLPSYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0C7</accession>
    <name>A0A922I0C7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0C7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="182" mass="20359" checksum="BB4213A5B1020BBF" modified="2023-02-22" version="1">MFDDLVPIDSYHKMSMVHKETTNYTDAYADACHATANLAISRPERPSIIPITYLRRLTDGSKTNLSKYNRTKRSRSDNVGRLNEINSSKRSCMAQSNCSGVFDANTNIKRLDCSPVRYRKAFNAERKCSLKVSEALLRRKASASSTNNKRPRRDVVAQLNNLCMAVTPSRPIGATSPPDMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0L8</accession>
    <name>A0A922I0L8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">YPEL5</name>
        <name evidence="7" type="ORF">DERF_007514</name>
        <name evidence="6" type="ORF">HUG17_1893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0L8"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7646355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9516795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="119" mass="13648" checksum="7F4949925BE88A33" modified="2023-02-22" version="1">MGRVFLKHIGGQRLYVCASCETPLTNRNQLLSTRFTGATGRAFLFNNVVNLSYSEVQDRVMLTGRHMVRDVSCKNCDTKLGWIYEFATEDNQRYKEGKVILERALVNETDGFNENIHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1Y9</accession>
    <name>A0A922I1Y9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZDHHC24</name>
        <name evidence="9" type="ORF">DERF_006716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1Y9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="86"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9515945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="281" mass="32788" checksum="74BE090D92322D1E" modified="2023-02-22" version="1">MFWKKRYSELLSSIFFLSMIIIVFIFEVFVIRPYLLESNVSNFVTLHLFMAIVLLTNTCLNLYLVVHTDTSIIGMVMPSITPLPPQWHYCYACESNTPPRSFHCKTCNRCILRRDHHCVFTSCCIGYKNYKYFMGLLFNVGFACTYATIMHWHYIWLNINHLGLWAIAAHSVPLGFYLLGMIDLWTTCCNIISMLCIVGAIFASGLFIYHFNLLRMNRTTYERAKSIADYDLSDWRRNLSETLGDRWLLSIFLCPLIKSSLPGDGVHFQTKQEKYLQNKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I271</accession>
    <name>A0A922I271_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Abc transporter sub-family g-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_004336</name>
        <name evidence="11" type="ORF">HUG17_0468</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I271"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03230">
        <property type="entry name" value="ABC_DR_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1710.10">
        <property type="entry name" value="abc type-2 transporter like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038:SF3">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 20 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="56"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="10">
        <location>
            <begin position="538"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7644930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9520636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="769" mass="86485" checksum="A416E767429F3A7E" modified="2023-02-22" version="1">MATSSEQQQHTNPSSEIIIDKDPSMDTVLTLPANNESPTINSDTCNEVFGSCNLAIQVEQVRLSYRKGTKLTPVLNDLNMIVPIGSIFGLLGPSGCGKTSLIRCILNCLKPDSGSIRVFGKKPGSKESNIPGMDVGYMPQDITLFDDLSIRETLEYFATLYQMPAFMTTKRIDFLIEFLDLPESSRRVSALSGGQQRRVSLATALIHRPPLLILDEPTVGVDPLLRQSIWQHLTELSQSERLTVLITTHYIEEARGANQVALMRNGQILVQQQPNILLQQYHLETLEDVFLKLCNDRHLSMDDSEIDDNGETTSTSHEDDPNWNDSCSNGNAIDSNDNSSGISSLAKSKQMAKSNDELFDGYESKRSMYSYWRKNVSIKNQAFYVKQTMAIIRKNTISLLRSPGNLLFQFLLPTIIVILFCACIGRNINNIPVAVYNGDWQSKVTVDILRELDPVSINQIHCRTAEQALQAVRDGHASSAITIYENFTESLHDRLLLMGNVDEETLNRSTIQIFPDMSNQIIALTVYEKVIDTFQMVARKYLHQMGSSPALIEFPINFSTPIYGSHQSTFTEFMAPGVILSIAFLAAIPLTAMVLVVERKRGLIERTTVAGVTNFQFILSHLITQFFVLLVQVVLLMICVFPIYKIPYHGEFLFIFLLTLMQSFCGMSFGLFVSSVAADELTATMLALGSFYPNLLLSGTVWPIKAMDDYMRYFSYLLPQTIPIESMRYMISRGWGPDRFEVQLGFIVTTTWIILFTLAASFLFKFRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2A4</accession>
    <name>A0A922I2A4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CDC14A</name>
        <name evidence="8" type="ORF">DERF_004838</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2A4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000006">
        <property type="entry name" value="Dual specificity protein phosphatase CDC14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="219"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="299"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9521167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="454" mass="52870" checksum="DF4C8A5A3B4247A6" modified="2023-02-22" version="1">MSISASSSSSSAARQMSRHSMTFRSPSKNFPTTLLEMVKERSLHFTEFLTNRLYFATVSEVNLNLFLKKSDSIVCFLHFDKELLYTPFNHDFGPLNLAMLYRYCKKINSHLQRNKTIIHLTTTNRFKRVNAAYLIGSYCIIYHHLLPDDVMARLKQLSISYVAYKTFAAFVDAGFDTSEYYLYLEDCFNAIYKATITEILNMEKFNLNEYLFYEKVENGDLNWIVPGKFIAFCDPQTYSDHSTNHYVKLYINFFRKNNITTIIRLNKSRYDPKVFTDKGFQHYNLIFIDGGVPGDHIVDEFLHIAETNPGAMAVHCKAGLGRTGTMIACYLMKHWHFTALEAIAWIRICRPGSIVGYQQKWLKLKQNFLWNHHIQQTLIQHQHLHLDLNNIKQQRTIQTGRPQRTGQSASTRQETFIMNNDDDDDDMMINSNKNNDDSNNNDNPTIITIVKCHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2E2</accession>
    <name>A0A922I2E2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2E2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7725" checksum="47A3453D72908E67" modified="2023-02-22" version="1">MNEDGQSYKGMLVIQDKDFQSCIIDPHRFNCKYDRIFFVLLFDDCQDYARSRHLPLFLYDSPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2Z5</accession>
    <name>A0A922I2Z5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2Z5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="110"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9518167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="431" mass="49703" checksum="AFA18330D335E691" modified="2023-02-22" version="1">MILYACPVWRSVLCNVTKRNRLLSLQRRFAIGMIRAYRTVSLEASLVIANIVPIDLKIQYWSEVFDAKNYPSLMFGSYQLPLKYAYTIHPALITSFDVHGIDGNMEFCCVSHNYYIFTDGSKIDGLVGASFVAFYRNDCRPVAVQSFRLADQCTVFQAEILAIKKAFEWIVANNIVDVQIISDSKSAIQSICKIYSYNRIVQEIFRTIVGYCNHLCFAWTRSHSGNYGNDLADFYAKKATLLPIIDYDQLSFTNVYRNFQSNMYGNWQQSWDVAMNGRITKMFFPTIQSRLKSKLQPNFVVTQFVSNHGKFGEYLSRFGQNNSSCSFCLSSMQSSLHLLLECPAFNLERSRFMINAKFNNVDVSAWLQDEALPLFLLSYKIITILVVKFKFLYVKKHSTMSENRFENSFEFGQQMSYYGIKNQNSPLDILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2Z8</accession>
    <name>A0A922I2Z8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2Z8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22661" checksum="DD3428A31EB51DD8" modified="2023-02-22" version="1">MKIFKILIIIVVLLLFTVIDIVNSLLFHNTNVKSNHHHHHRDGNGFSIGDDEPIYGDIHQIQSKENITLEEDRSSIPSILHQQQSQQQSSSSSLSSSIKNGKIFSSQESGSSKWTRKDQSSRNQQPTYDTPFTIFYFLIGLSITAFLFIIYYLNMKDLQLRSPTIRTPLLKIDNGHLQPKSPSSLTVSPLSLNQSRSFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5G0</accession>
    <name>A0A922I5G0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5G0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="240"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="722" mass="85098" checksum="E48AF4C6E2D6EEAF" modified="2023-02-22" version="1">MSEQNSQNNSDDDDHHQNCCRCQDEINGRQLNDNDTISSIPTTTNVNTTNSANNESIINVMMDLNIANHRQQQQEQGFMLSSSNQIQINICIADDENNNKIQSSSSSPSSFISNNNENIGDSCLSNDDRKENETVSIAKIKNDDLNDIDIVGQNKQQQQEIQLYFPVDINNENNQQQQFVIVDDRFENINDNYSTSTKAVTKFLSKKEEKKRLKHLERQQRKRMMNRYQQLQRRIYWNYMPIDILEEIFQLLSIKERHLASQVCPHWFECFYSPTIWTTLIVTDKSFTKRKFNYYLGYQRMIDSFKTQAFLWKFGTNIRRLIIKPMNNFFNLYEFMKILSQFAEHYQPNRLRNLNRFDFTFGCRPIHQSINGDNNNNNDQLQQQHHHRRHHRLSTGDIRNDDTEVIGTGGKLLEALKELMYHLVGLKYLALRDLLLCPDEARYLLDNVAINCHEQLRTLTLINCCKNSYAFLHVGIFLNLDTLVISCQHLDEDVLILLALNRSLNHLYIVQTELTRSQGPLSFGLWKKFSKINHHIQIHLVMVNRTTSRCCQNPLTYELSLQPTRITSIIYDAPIIRPSCTRLIEIGQLYGQSLECLAFYHIPKYTIHRSYMDRVDTFLIYISENCSRLRTIIINDLISTATLLLIVTYARNLTTLYIRRNAIRKRFDCLINPSWREHFVQWLRQTSRSYEQTFSEISRMLGYRWIPLTDDQFKRLRPNVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5M2</accession>
    <name>A0A922I5M2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005566</name>
        <name evidence="1" type="ORF">DERF_013568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5M2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="178" mass="20525" checksum="45CC30AEE837BA17" modified="2023-02-22" version="1">MNENEIVPSENKYIDSEKCLNCENDKSPAAVINEQDEVTKENAVVWDHNITVDSDEQIETTTIIGKVINKASPTNSELVVLGWTCHFLDSELVVLDWIRHFLDSELVVPFDIFISVPYKFLKKYMKYKFHFFASQFSSLYFLGKIGWQSNSDSAKIRLSHHQIPGIHNYPAQMCHLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5Y0</accession>
    <name>A0A922I5Y0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5Y0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="88" mass="10642" checksum="D53F8EA3C7501130" modified="2023-02-22" version="1">MQNIRVPDRRTKQRKKISNTNPNQPCKTNDNMYIKSRKKLPVLRRGEKKRKLYADMADTWHHHRFWNSLGIHSIQYNSFLKLSISITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I600</accession>
    <name>A0A922I600_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="758"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="856"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1568"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1719"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1757"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1811"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1955"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1629"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1294"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1580"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1757"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1833"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1955"/>
            <end position="1971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1979" mass="225953" checksum="815A4FCCDA43278C" modified="2023-02-22" version="1">MLQRLKLLANNNDVDEYKQSSSSDHGFSSSSSSSSSAISSPSLRFLKSESGSTTTASSSSSSSHSSISSRMAITSNNDQKMLSKSLSDLMFISNSLPSSSSATTTDNSCSSSSSSSECLGTLKYTDDQSNCNNSDQSVTLSDYSSSSSSSMALKFTGKQLMKTKSSILQNPVMITFPRPEKIVPSLVDQSNSITQSESEDVSSLTMAPNSIDNQSDCSELTLSSTIQHFGQCLNVDQQQKQTDSESTLENDDIDPKSIDHHNNKISAISVPNLTFMNTQDKQCSSESKNMIKSMDPPKLTTPNGIYKKNNNFNGGKRSNYFAQRYVQNSNPTNSDTQMIMNRNTLPNNLMSTTTTTTTTTTTTKTKRIPSIDSNLSLGCSTATIGSTYHRYLTYGTSAQLQQEYGKFLPWPTLTEFRLRRKLRRFKRRARKLFNGNNLIGKSFNRIQNVKKIIKMAKMAKQDPMFINGNSDNNNVQATISRSSSLTSLLNLIEEANKNLLNSFHEEDMKKRNQLFNSQYMLSTTTTTTNQPPKCPPRLKRAMSSINVGEQTKQYANTTTNNNNKQSSSILMNKQKTLPMMEQRRWITKNTTDSYRIAFVENKNLRTSNNQQQVKNLSNDLDTISVKSLDSYFGQISLNDNHHQQQQQQQQDSIKQQQEQRNSKILCVRSHFQINDGTIYLEDSDWEMCSEISEPLSLNESIINANDDDVNIDTSLIDMALSKSIISNNGEISILPSSSEEKTMAATANIESNVSVSINDATTPSTNDDGCKSSSSPPPIPPKPKLIDSTLKKELNNEKLSIESTESNKSIQQPTIDNVRTKLDTNQHVHEEKKLINNNKSKNVRRIEESITMKRPGESKYHQNCKHSHSSSLSTKSNILQQKSNKFSIEKRRIKPRAPPPPIVTKSNNVNVMNNKKLMNQTKNVKDIGRKLEETIKKVHDKNVEKISLSKTTTTTTKINANKKQTKVDKKNDENNQKRFKILGKFHKKTSTSLADNKPKNTNLIANSVEKKIKPKECIDEIQTVNNENIGVSKSIVLVDKSDDNPLQLTQERQPDSIEFLIEKFNENKAHEKLSNDHLIDHESKNQQEKLIESNIQNENIMNDDDDKTLTRTYSMFKSLMNSSDMNSLASLIDNNNDNSSSYLYIENMIRRIVIEQQKMMMSKDDNNNNNNNNNNNKNEKNNDNLLLMLLMLQYQQQQCQQQQLNELKLLQTIQNIQQQQKKSNDDVDFTKILIQLQKLLEDRINNNNDDNDNDKENDDQLIEMNKFKQFERIEKLEKEEKQNDLSFNLESESNDEKSKTKETKIEQNSTVKCENSNRFVNKIVLNNSINQYNFNMKCSNSLDTNNNQSSLDAEIMNRTPPQIINVLTDNGCNQASNQFDFDSINSTICNSRTTTIAEENSTNEEPVVAGVNVNLVNVEHQPTVTTANDNDEMMDKPQHRTILRLNSNSHQSKFGFIHSLRYQLEKKRNKSRMERLRKEQEKFQLKQSTLSLSTLIEDQELTTTTTTTTTTTKPSSSINAKTMVTLANTSTIEIKSSTNNQTGMIMNQSNDQNKNSKTGTLRRLFSLSSTTKDMDDEQMRRKKLSKDKKNKNKMIDESLKLQNIKHKNKKFSSSSTNISDISEPYPFGIESILLQRSSLKNDSEKMKNQQQQKDYYNNRHHQQYRMPMIKRSSSERNFRSIIRLNESLNQQNDNISIIVENDDDDGYMNGDYYYHHYNHGDYNNDDYNQQQQQRQHEDLDSYSLKHRQINVTNNRKKNKSYNHHHRRHIDGNNGESTRFGSQINLSTSSLSNISCSSQLGVSRMRLLDSRCRQNQQQQKKLKMKKSSPINDGSSNTSLSTTTSTSSSLLRQPVVTFTLPKNFKSQQKYSFNNNGQQPRIMNFEYDERYFRIHGDHGNFLTTDDDNDDTDYTDSVITTIDNNDEIDDHDEYYQLSPNSKLNERYFRFGSGSGIGRSHSEMMLKNDDDDNHQYDHRRRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I652</accession>
    <name>A0A922I652_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">10-formyltetrahydrofolate dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALDH1L2</name>
        <name evidence="15" type="ORF">DERF_005698</name>
        <name evidence="14" type="ORF">HUG17_3353</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="1.5.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.6" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I652"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016155">
        <property type="term" value="F:formyltetrahydrofolate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009258">
        <property type="term" value="P:10-formyltetrahydrofolate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07140">
        <property type="entry name" value="ALDH_F1L_FTFDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000002">
        <property type="entry name" value="10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000002">
        <property type="entry name" value="10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="entry name" value="Formyl transferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011407">
        <property type="entry name" value="10_FTHF_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036489">
        <property type="entry name" value="10-FTHFDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="2 3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="13">
        <location>
            <begin position="207"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="328"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="437"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="714"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>(6R)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>(6R)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="604"/>
            <end position="607"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="637"/>
            <end position="642"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="657"/>
            <end position="658"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="764"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="811"/>
            <end position="813"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036489-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7639320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9522095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="913" mass="102100" checksum="D2DE3C514DE5CAFE" modified="2023-02-22" version="1">MKLALIGQSLFASSCYQLIKENGHTIVAVFTIPDQNGREDPVAIAANVDNVPVFKFPRWRLKGKILPDVFEQYKAVGADLNVLAYCSQFIPMEVILYPKHQSICYHPSLLPKHRGASSINWTLINGDHKGGFSIFWCDDGLDTGPILLQKSVDIDPNETVDSLYLRFLFPEGVRSMLEAVDLIEQGRAPCLIQPEEGASYDPMLNKKELYELKLDELSGQQVHNFVRGCDTVPGAWIRIDGQMIKLYGSKRWRRPIPTKVQEITIDNCQSKALLHKDGMILQGKDGQMIIVSKLGLENGKMIPAAKFGQQDESSSLGELSEIEKELVEQIRTIWKSILNTDIDDSSNFFKLGAGSMDVTRLVESVIELDQCEQLSLANEHVYMNSGFDEFYSMVIIKLRHGGQDDDRPKIEYKPIEMVVNKRKLRFPNQLFIQNEFVDSSNPEKTFKTINPTDETVICQVQNSTREDVDRAVMAAQEAFDYGEWSQMNARDRGKLLYRLADLMEQHKEELATLESIDSGAVYTLAIKTHVGMSIDTFRYFAGWCDKIQGETIPINNARPNRNLTFTRKEPIGVCGIITPWNYPLMMVSWKMAACLAAGNTVVLKPAQVSPLTALKLAELSVQAGFPPGVINILPGSGSVTGQALIDHPLIRKLGFTGSTPIGKLIMKSCAESNLKKCSLELGGKSPLIIFRDCDMDRAVRHSMSAVFFNKGENCIAAGRLFVERSIHDVFVQRVVEEVKKMKIGDPLDRSTDHGPQNHRAHLEKLIEYAETGVKEGAKLIYGGRQAPRPGLFFEPTIFTNVQDDMYIAKEESFGPIMIISMFDDVQNQEDIEEVIQRANNTEFGLASGVFTKDLSKAMLVSEKICAGTCFVNCYNKTDVAAPFGGFKQSGFGKDLGREALNEYLKTKTVTIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6H0</accession>
    <name>A0A922I6H0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_008788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6H0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000110">
        <property type="entry name" value="Nuclear factor Y, subunit B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="43"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9518195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="161" mass="18570" checksum="4BF5D36C9888507B" modified="2023-02-22" version="1">MYQQPENSNDNSLMNDQMGHTTDSYDSGDNDRSELLLREQDRFLPIANISRIMKRSIPANGKIAKEAKECVQECVSEFVSFITSEASDRCKQEKRKTINGDDILFAMSILGFDNYIEPLQQYLIKYRDFIVRNDKDIKNIDLKDDVSDTSSTNQHEDDSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7T2</accession>
    <name>A0A922I7T2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="17">1.3.8.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">DERF_000637</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="33">Derf</strain>
            <tissue evidence="33">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="33" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="33">Derf</strain>
            <tissue evidence="33">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:19181"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.8.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:19182"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>dodecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:47297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:47241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H(+) = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:43449"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>tetracosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:74693"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:47233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:47317"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 28">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer. Homodimerizes after import into the mitochondrion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 28">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.9" evidence="17"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7T2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017099">
        <property type="term" value="F:very-long-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000008">
        <property type="entry name" value="acyl-CoA dehydrogenase family member 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000006">
        <property type="entry name" value="very long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000001">
        <property type="entry name" value="Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF11">
        <property type="entry name" value="VERY LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 28" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 28" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="31">
        <location>
            <begin position="93"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="30">
        <location>
            <begin position="203"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="29">
        <location>
            <begin position="315"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="32">
        <location>
            <begin position="514"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00046812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="KAH9526561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="645" mass="71768" checksum="024494DAACD24CEC" modified="2023-02-22" version="1">MFRSIAAKLYSPRSDNIQLIRNLVVRISTSSSRAQPKTTEKLEAKVDLDKLDKIKVPESNSFVQNLFAGRANTEFFLPYPQVLNDEEIGFLDMVIDPVSKMWEDKWDEIVKQEDTETVPEDVMEMMRTMGVFGIQVPVEYGGMGCNNTQYARMGEMAGRYDLGIGIVQGAHQSIGYKGIVLFGSPEQKEKYLPDLAAGNKFAAFALTEPSAGSDAVSIKSRAVLSEDGQHYILNGSKLYISNGGFADFFTVFAKTQIKNEKGEVKDKVTAFWVPRGPGLTSGPNMKKMGIKFSNTTEIWFDNVKIPKENVIGEVGEGFKVAMKILNNGRYGMICALSGTMQKAIEMASTYANTRTQFGNKLASFTAIQEKIGRMTLAHFVTQSHAYMISGVIDKGMTDFQLEAAVGKIVASDSAWWVCDEALQIFGGMGYIKDTGIEKMLRDTRIFRIFEGANEILRLFIALTGLQYAGGHLREIQKAMKNPMANLGLIFMEASKRLKRTAGMDAPNITENIHPSLQAEAQILSKNIMLFTSAVEHLLIKYNKQIVMEQMLLLRLANSVIDIYTMLVLLSRVTLSLNKNVSSAEYESQLCKLFIAEANMRVNQNLTALRSPVILKNDESIRNIATQVLNNEGILHQSPLHSYESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I803</accession>
    <name>A0A922I803_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I803"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="127" mass="14490" checksum="D7BB3FCE24F2E77C" modified="2023-02-22" version="1">MIAIYMPEKSSFFVWIVIIVVVVVDDDDVRVTISFFSEKQILLPYTCDHLFIDVVDDIMIMMMIPTIIQVYFLLSLVDIVDTCCFSISLLSLTAEDENMEKISTLVPVFISKGGNIVERENAEIRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8C8</accession>
    <name>A0A922I8C8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myelin expression factor 2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_000289</name>
        <name evidence="5" type="ORF">HUG17_8125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8C8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="68"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="211"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="501"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7640656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9526187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="571" mass="62814" checksum="E081169D72EB1196" modified="2023-02-22" version="1">MESNENGEKKIEQNTSNNDLPKSSSNDSGRSKDSGRSSSGGRRDRNRSRRRSRSPIRSREDRSNKIHRRVYVANIPFDVKWGELKDLFRDKVGNVRFCQLFENEEGKPRGCGLVEFEDSASAKKAIDVLNRFDYKGRELVVKEDLDIDRDRFGRLILSSGREDRERDRDRRRDRYDDRYSNGSDSGSTPYHTYGLSPQFLNSLGIKGPLTNRVFVANLDYKVSERKLEDIFGLAGKVTKVRLYCDHEGKSKGFGVVEFEHPVEAVQAISMFNNQKLYDRILSVRLDKFDNEDPFGKDGLPAKLPRGLESIGKGLGIDGQPLNIAKSISSPAPSMQGQSLPVPSPITPQASNVTPQAATAAINVLSNLAGHLPSLTQSLAQFSNNPSGTIAPQPAASTGYPSSTNDIPGSGNTVPGASATGYGHSGYTSVVPHGNGTAQPAAPYPTTSPMMPPSSYGTAPPPTSSVPYSANAGTPNAPISSYSTYDQRGDYRDDKYRTSGIDTIFVRNLPPNFSWQNLRDRFNEVGEVRFAEIKGHGTALVRFGSDRDAQRAVDLMNGIRIENRAIEVSLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8Q2</accession>
    <name>A0A922I8Q2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8Q2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="102" mass="11841" checksum="A103371936E68497" modified="2023-02-22" version="1">MPNNSWRISRVIYDDHREPIWTMETPNKAATTTTTTKNLRFKTMTPADSPLINFCTLKTVEYWIGIRINQCRLNLIFIVIGLLNSVIYPFVVLILPSFKLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8U3</accession>
    <name>A0A922I8U3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polycomb group RING finger protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PCGF3</name>
        <name evidence="9" type="ORF">DERF_001118</name>
        <name evidence="8" type="ORF">HUG17_4354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8U3"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000033">
        <property type="entry name" value="Polycomb group RING finger protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051507">
        <property type="entry name" value="PcG_RING_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45893">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7641310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9527074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="228" mass="26929" checksum="56A9E99A16F0B33C" modified="2023-02-22" version="1">MERRIKLKSLNPYITCKICKGYLIDATTVTECLHTFCKSCLVKHLEENNTCPTCNITIHQSHPLQYISYDRTLQDVVYKVVPDLQQNEIEREREFYRSRVMPYPKSNLNLIKMLKDGNLNHPSQCTSENYHRDDEQIGIELITSSEELIKQIKAKFIRCSSQLTINHLKKFISKLIYKTTDKHKDIDILYNEELLGKDHTLKFVFVTRWRFKSGPLKLYYKPSHNLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8U4</accession>
    <name>A0A922I8U4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translocon-associated protein subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Signal sequence receptor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SSR3</name>
        <name evidence="12" type="ORF">DERF_000416</name>
        <name evidence="11" type="ORF">HUG17_8226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAP-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8U4"/>
    <dbReference type="OrthoDB" id="10059529at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009779">
        <property type="entry name" value="SSR3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399:SF2">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN TRAP , GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07074">
        <property type="entry name" value="TRAP-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7640757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9526318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="183" mass="21097" checksum="31FE77DB8183BB6A" modified="2023-02-22" version="1">MTTSKKMLTREEELLLQDFSRKISRKAMIMFYGIALVVSIVPLWLYLRIYQLELESYWILFIIGSLVNTWLVAFGYNNVKFVLKHKIAQKREDAVAKEVLQSLSGQQQSMNKKEKDERILWKKNVVADFEATTYSIFYNNAIFYTMVILGSFYVFRSFSPTLNYLLSVVGSGAVVALLSTGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I954</accession>
    <name>A0A922I954_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit</fullName>
            <shortName evidence="9">Oligosaccharyl transferase 48 kDa subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_005309</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I954"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038158225" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit" evidence="9">
        <location>
            <begin position="19"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="10">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="11">
        <location>
            <begin position="292"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9521673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="436" mass="49576" checksum="C24EA0641CB2BF7F" modified="2023-02-22" version="1">MILPISLFLLCFVRLSVANGSVLVLLDHLSIKETHSIFFKSLQDRGFDLTFRLADDATLSLTKYGTPLYQHLILFSPSAEEFGGNINTQAITEFIDNGGNLLVAANENVGDAIRELAVECGLEIDEEGAQVIDHFNYDATDDDMHTLIVVGTEDLIDAPTIVGDRSRINPILFRGIGMISDPKNTLVLDVLKGTSTCYSHNPLKEITEYPHVVGKNTILISALQARNNARVVFVGSLDFFSDNFFQSPIKIAGSPNVRQYDKSGNEQLALSLSGWVFKEQGVLRVSSVKHFKTGTNENDSYTIMDDVEYWAMIEIFDKNGKWIPFDANDIQMEFVRIDPFIRQTLRKENNEYVARFRIPDVYGVYKFIVDYKRVGYTNLYSSTQVSVRPLQHTQYERFIISAYPYYFSAFSMMFSVFLFSFVFLYFREPTMKTKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I989</accession>
    <name>A0A922I989_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Actin- protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ACTR2_1</name>
        <name evidence="8" type="synonym">ACTR2_4</name>
        <name evidence="9" type="ORF">DERF_000005</name>
        <name evidence="8" type="ORF">DERF_009005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I989"/>
    <dbReference type="OrthoDB" id="10251209at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9510485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9525870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="413" mass="47253" checksum="785F937ED9844E15" modified="2023-02-22" version="1">MDSEGRKIIVCDNGTGFVKCGYAGSNFPKHTFPSVVGRPIIRAAQRIDDIEIKHNKEEIIESDLMVGDEANKLRSYLELSYPMENGIVRNWDDMCHVWDHTFYDMLQIDPKNSRILLTEPPLNPINNRKKMIEMMFEKYQFHSAYIAIQAVLTLYAQGLMTGVVVDIGDGVTHICPVYQGFAMPHLTRRLDVAGREVTRYLIKLLLLRGYAFNHTADFETVRMLKEKMCYIAYNCEQEQKLAEETTYLTETYTLNDGRIIKLSGERFEAPEALFQPHLVNIEGQGISELLFNTINSADLDLRSELYKHIVLSGGSTMYPGLPSRLEREIKQLYLERILKGDGQKLQKFKIRVEDPPRRKDMVFIGGAVLADVMKDHPQFWITRQQYEEMGIDHIIRLQSNNVASSSASVSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9G5</accession>
    <name>A0A922I9G5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Adt-1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">adt-1_2</name>
        <name evidence="13" type="ORF">DERF_000110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF275">
        <property type="entry name" value="STALL, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="12">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="764"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1207"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1277"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1462"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1208"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1227"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1284"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1472"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9525990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1482" mass="168195" checksum="27D80382EA55E75F" modified="2023-02-22" version="1" fragment="single">NLTPSDNIDTYLTNFCVWQHKKRLRETGGPTPDWDHALLLSGINMYVVDGYGRRKRHVVGLAPVSGMCNSLNSCTISEGTNFQTVLVAGHEMGHSLGMEHDGSQDGNVCNKDDFVMSPTLGPGKTTWSECSKNYLDKFVLTPQATCVLGRSSHVNIIHQFIPPHRLPGERFNVDDQCRFRFGPTARHHSSQPKSEICRVIKCYVKSPVKSNGSNSHHGFYSGRGLYAYPVKSTYNTHPALEGTECGHEKWCREGRCLAKPNFHGNNEISDNDHNDSNEQQSDINRYVQWELSKKNATTITKNNGDKIKLKTQSTRISNRHKKRPTLGKINNDAMNTDGAADGSPAINIQTNWHYHLKNDPYHYKLSNDPKFISSTPKPTSSSSTAKPSTILIVDNVYKSKSTNTKNNTEETTTIVDAEANYLSDDQYNPYNKLTNKDRFNWSSNRLSQIHHHKHKSITVNGNWSYWSDYGPCISECVAPGNNNNNNNNKKGSENGRFQSSIMVPLGVQTSLRRCNSPSPLNGGQQCHGPDTRVKLCNAVKTCSPYSATSAATGSGAKHRTKLDPITAGHRYQIRSVDEYISDTCLMAAKFNDKIENHGTQYPSYDSASHSCFVWCYKRGGGFMTQGWRLPDGTPCGRKLALSSVNSDDPTATSTASKDIIETTGYCYNGQCRRFNCRGEIFHRQSIIPSTSSTNVYNVYQNHSTTSIMLEQELENRLLRDNCPSNYRLDDIIQDLEDQIDDWDQNYDFTYRLIEKVKNTIPISKSESSTQIPSVPTHTMSTNSPTQSPPSSSPLLLVTTNPYMLPQNNWSDWHPVTECQYSISCIRNGRGFRLVTRECRRQTCLGRREALQVCPEVLTDKSIRDPSMTTMYNLYEQYCPISIRRSANEYAQSICHKYQTKFSSLLSGNGRQLNHGCIVACEDRLWPDVHYQMDAFTDGRFPFGTDCSTKDRRGYCLNGKCIHFDSADISYDTAESVLYRHEILQLFAPSTIFPLEPSLYGSSQTPMTTSTPSDSLYSAIFNQEIYKRASKTLQLSTPSPSIGSIELQPAYQSFISSHRRIKRQIMATTTTTAATGIFRKASVQEQTDPEGDYVSWTMLKHHHHNRPQHSFNPQHHHRQYRRPITRTMKNARSMTIDWSPLVIKPLRPIRLTSVTRKRKPQSSSLDSHFQTFTLVAKPSRNRFRTRPSLSTSFIQPKIHLVKNITRFLDDDDDDEDDDQQNDKKSTTKMKVSSTTKTNLTMTNHKSMNQKSKAKFSMGHESWPPIIMTTRRPFTTANMSTFLDDNNGDDGEEDSTVSSINHDQDDDEDQLRVEPYIWSVILSECNRPCGEGIRTVRVVCTVGQRSVQEQFCDQQTKPIHKSIETCKERDCIGRWRAEPWSKCFIPKRTSKNRCKPKQQSFQSRTIACVGPMMMGHHNPNRPNESRIFSLLSHDYCDPLTRPNQWRSCDMIDMNMNDDCNNHNNDDEDKTIINDNDDVETVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9I9</accession>
    <name>A0A922I9I9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9I9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="119" mass="14004" checksum="B3835D0C2207590B" modified="2023-02-22" version="1">MTMRKVKNRVANINSQKDNNNHQHHHIKTILPSSPSSQLQSTSSGFIPIAKPTIISTSSSNNNERNANNLLQQQHNPLHLNHHHHHHHHDYNDNQHQHHHHQIHHNNHPYQQQIKKMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA97</accession>
    <name>A0A922IA97_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Choline/ethanolamine kinase-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_002259</name>
        <name evidence="4" type="ORF">HUG17_10223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA97"/>
    <dbReference type="OrthoDB" id="6497831at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7636253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9528307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="399" mass="46875" checksum="0B022289EE2311B4" modified="2023-02-22" version="1">MTSKSIDEAEKKLEKELFKQFKDINPDDLIRGKTPDDISNRCFKLVQIYMANNDQWKRLCKTTNDLNVRRISGGLTNQLYYVGLNNSINETDNAITIKFYQSKHFKKDVIDDDSDDERLSDTIISIIISERGIGPKVFGILPDGIIQSYHEHEQFRPKHQHNDRLLKKLAYLLAQLNNLDIPIAKDKFYLLDIITSYSHEGYRRHNVSSLAKELNLRYLLENDFLAEMDWFDSFIRHYLDQCPMVFNHNDFRGSNIMVLKDSEEMLLCDFEYSSYGFRGNDIATFLMEWDRNFLDFDDTGLPSDDVIEKFIQLYLEGWEQIDPGYSTRAENSCQKIMNETKIGCLFVLINIMAVTLHQKESIFADIPFEPKKIITGVNFMFKRYLNFKNLLIEEKIIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAE1</accession>
    <name>A0A922IAE1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAE1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="215" mass="25015" checksum="279CC6F91E97A90D" modified="2023-02-22" version="1">MEELNISEKIELYKLLVANGFESIDEERLAQSPLADYGVEKIEKILNNYRKSTDSAGCLGDSISNLLNLKQHYKCEFFNTTFADIMMMKAKSFDDNDNEYAHVYRFIAQLLRGQLADLSELNEKSMNIMLTLIREMQLLVNSFDSNRLLVSESDEQQQQENVKEKQTLETLKSMFKFQRISEFMNPLNISAETNDRLLQLLLDAEDKRRESTKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAR5</accession>
    <name>A0A922IAR5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PHD zinc finger</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Protein pygopus-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PYGO2</name>
        <name evidence="12" type="ORF">DERF_001377</name>
        <name evidence="11" type="ORF">HUG17_4573</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in signal transduction through the Wnt pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAR5"/>
    <dbReference type="OrthoDB" id="270215at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15637">
        <property type="entry name" value="PHD_dPYGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000107">
        <property type="entry name" value="pygopus homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052475">
        <property type="entry name" value="Wnt_Signal_Transd_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23194:SF16">
        <property type="entry name" value="PROTEIN PYGOPUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23194">
        <property type="entry name" value="PYGOPUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="192"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7641529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9527357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="260" mass="27356" checksum="2E11795A7A6467A9" modified="2023-02-22" version="1">MPRERKSAKNKQSAIAVDHHLDGSEPPVVKAPKKRRGSAANSGSGMRGNANQNQNGDSMMVPPPQPLGSGYGDTLYASNPFDDTPPMCPPIPPGGNAHPVGMPPQMGGPMSQHGPPNAGPMMNPNGPGGMMPGNARMMGGGGGPRGMSPGMGPKPPGMMGGGPPPPMPGGGRSYPPEQSMVFNAANPNAPPIYQCGFCRKEIHDNDQAILCESGCNFWYHRICVGISERAFILLTQEVYAEWVCDNCNNSKNIPLIKFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAZ3</accession>
    <name>A0A922IAZ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAZ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="403" mass="47063" checksum="3B13F5EE7416D92B" modified="2023-02-22" version="1">MLNVCSYDDPAMRLIQKLERKLSFRRKQLISDSSTTNFSKSFNKNDKENVESSSIKVSETEFSGYIRFNNCLVSTMSVPDSSYKLVDIKIRNRCEPIRSENLRNLPQAKPASNHSDNQHSLYGCKEMFDKNHIYDVVGQPSLVNHEHDYYHSRNRIRTNPWYNSRSGLNIKQSDDIHHYEYIDWEDTQDVQSLSSPISGKNLSTFDRPIHKSPNVQQQKLSSIIKTKPFKQSESNVRLKKSIENPYEQLPYDNSFDAMLNHNYRTESKIEKKNNNDHSTTRFSHSRTKLIAAINNKQKQINNDHSNCYKRSPYQMKFDTTNNNNDFCLKRKFIQNKDDISSSSSRAIKRRKNDHHVNVSSSSSSSPALSKKRSRKIDRLKFELKEIVHVAIREAKNEDSHILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBE5</accession>
    <name>A0A922IBE5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBE5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="135" mass="16133" checksum="0EA724339C62FAE9" modified="2023-02-22" version="1">MTFFFICHRRIYFDHLISKKMQNIKTLARPTFSKQLSTSIRSYSNDSTNWFKFAIGKWNKFFYGGEQPYDSRDIIFENMVAEGKTSVMLRYMQKILYAREKARTRIVKHNEHIRKLEDKISDGGVIKPKSFANRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICG3</accession>
    <name>A0A922ICG3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICG3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="6680" checksum="6F77ACDFEA07BBB1" modified="2023-02-22" version="1">MDPISNGCLREPPTGLLSHGSTGAVSYSGVNATVTAPGTRLQRWPTIGFHLLAKLPPITIIVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDC7</accession>
    <name>A0A922IDC7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDC7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="139" mass="15914" checksum="E923D606B55B3802" modified="2023-02-22" version="1">MKFLTVQNLCPINKDDKMTTRCPTNQKFPQNHQMSNVPRCISQSKLEDVQIEQSDEEEEIIEDGGSVHQIIMKQLNAYPENKLKTGEDSTEDIIRREDTTSDETPSTEDRGPISTEEKPQSSEVTRSQQMFIDVIIIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDE5</accession>
    <name>A0A922IDE5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDE5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="194" mass="19183" checksum="3530441AB2DD5B60" modified="2023-02-22" version="1">MASTSSSTYRTRMASGLFLLAIIVLELVLISDNITSVQAGKKKKIMKKLKEMLPMMMMMMGKKKMIIPVPIPIPMKESGGCCHGGGDYGMGGGGGDEGGDSYGGGGGGYGGGGGGGYGGGGGGGYGGGGDDCGGGCGGKKIQLTLDMPDMGMGGMDKLGGMMDGIKDMMGDMMNKMPKMSMSGSDCGGGGGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE52</accession>
    <name>A0A922IE52_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Neuropilin and tolloid-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NETO2</name>
        <name evidence="7" type="ORF">DERF_002644</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE52"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000013">
        <property type="entry name" value="Membrane frizzled-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF28">
        <property type="entry name" value="NEUROPILIN AND TOLLOID-LIKE, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="193"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="321"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="591"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="852"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="942"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="971"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="870"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="903"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="950"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="983"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9528726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1033" mass="114124" checksum="3158AFF9035FBDA3" modified="2023-02-22" version="1">MVTTVVFQPIYYHSKLVRAKDFSNAERDAALSAAFKSSSSSTSLSLSSSATSTVIGGGHRGTLDNSLGPVILPPPPPLPQLPSSLTSIPSIISGQNVLDNNNDTPDSFLLSSIGHQSKSSIKQIEKREPTKNGSKKLTKKPKSSQQQQRSFSAYIQADLSPLELDDTIFDAVGGGSGDPRFDAMISIDPNDPCYNFTVGNLKYQEFFSPNYPNNYPNDTECERVIQAPHGYQISIEFRDQFSLEDSPNCAYDYLEIRDGPYGYSAPLAKLCGPDFPRDIISNDRYLFLRFVSDDSIEYQGFRAVYSFIKMTNERPEPPDDCRFNKTGVSGTIENRDIPLELTNYSVTQNVPIDCMWNITVAAGYKMYLNFKEYKLTSPNNCEANYIDIYGEKLSDLARKQRFCGTQAEPVRSDDNHMNIRFFAKPDALSNVQFEITFTAFRELSNKAETCRPDEFDCEDSTCIDIGLKCDGVDNCKYRYDEDKQTTCAPGNKGVLNLNSQHMVVILIVFCALVFGMCASIAISCWSKIEERSQRKREYKLRRSREASMEVGLDRTMTITSLDRSCPLEHGEQTSSSSGSRCRKIVTANAIRQKPDVGSGGGGGGGGVDDDDGPTMGYYDSEENGCYVPDLDIAPMHHHSSTSHHHLVYPSSTERRPKQMQTVQPNGGTICTAHHLDPADKYSPDTPTPPQMMIGSPNTRGHVGGGGGTQSPLVGGDHYYHQQQQQQQQNIERDSIRSSSDCSIPPPPPPPSLSHFRNRLQQQPQQYRTLPLDPSKLTDASLLIMSDNHHQAVQFRHPQHTTRMIATGAGQPSSMMIHPQHHPDCAQHQLNKMQQASIEHQSQYNPNSLRRATNYYTNQPTTGNCGGGVRQQPTSGNSNPGSQRPSPMPIGSSGDTNELLNDVIDVDGCIDEGDVESGVGHSEQRSAMELNDDVIDDDVLTENDIYPPSNGLASTSGRHQPSTHYLLRGQSTLEEEDDSSVPLNSTNSNTGYGSSGQQTIMPPNIGQQVYYRSEAVIEMAPRPDTNRQDVALIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFU3</accession>
    <name>A0A922IFU3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFU3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9530102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="79" mass="8868" checksum="B48BD523BD5A8498" modified="2023-02-22" version="1">MPLIQRNLFPSRPPSKKCDGPSVLRAANNINNNHNNNSMNNNHDSINNRTIINPNLSGRTKVKISYDSQDSFNTSSDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFZ1</accession>
    <name>A0A922IFZ1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_003438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFZ1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF238">
        <property type="entry name" value="SD10469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="39"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9529560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="594" mass="64651" checksum="8E43A7504BAD763A" modified="2023-02-22" version="1">MNGIPDTNIMVSSQSFNKDLEQQYRLSSADDDSPIDGGFGWVVVFASFMCNVIVDGIIFSFGILLPEISAEFNENKATTAWIGSLQTGLYLIVGPLVSALALRYDCRKITAVGSVLAAIGFVLSYFGTNVLTLYVTFGILGGIGFGFIFLPAIVTVGYYFEKKRAFATGIAVCGSGIGMFIMAPIMHFLVEHFGWRVSVLILAVITLFCAGFGSFFRPLKYDPRTDEEVPPPGAIQPKPLLMRIKEARAAAWARSEEELSEESPTSSQNSAPPPYSEILEVVRTPTEDKIVSFSRNSLFQASIENRKRARSTIEAVGSRNNLQAAKKIPSPRDEMLYSNLSLVVIPQSRSYANLRSQSMGTITKSGEQMNEPSFCSGFDLSLLKRPSFVLLALSGFLCLVGFFIPFIYLSDRAKLLGCSPDKCAFILSIIGIANTVGRVLCGWAADSRVNALLLNNIALTVGGIATIISPIVFNSYYSLIFYGSIFGVSVASFATLRSVITAELLGLEKLTSAFGLLLLFQGLAVTIGSPIAGWFFDITGSYDYSFYLSGIAITLSGIMCYPLNAIAAWEKRFFGEKEQQNVNTISTNTDDDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IH16</accession>
    <name>A0A922IH16_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Y+L amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SLC7A6_2</name>
        <name evidence="7" type="ORF">DERF_003199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IH16"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000056">
        <property type="entry name" value="Y+L amino acid transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF531">
        <property type="entry name" value="LARGE NEUTRAL AMINO ACIDS TRANSPORTER SMALL SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9529308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="185" mass="19864" checksum="B3EB58F8BEB6C8E8" modified="2023-02-22" version="1">MADNYSIVPQQNRDVEMTTPVNNKSPSNDESDGQATTAAPTAANDDVICLKPKMNLLNGITVIVGSIIGSGIFVSPKGVLENTGSVGLSLVVWIISGLFSTIGAYCYAELGCMITKTGADYAYIMESFGPFVAFLRLWIECMIVRPCSQAIVALTFSFYVLRPIFPDCDPPADAVRYLACICIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IH52</accession>
    <name>A0A922IH52_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IH52"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9530189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="144" mass="16427" checksum="02F1744739C0AB15" modified="2023-02-22" version="1">MFEFCPAPKQQTTSEFDASIRHCNTYLEMVVLGVVKVIQQRDNVTMVQLLHERQFTIAITTNMAKRTLVKHLFQGDAQLDWIAVFIMAMIVLIDSEFPFGHFTTTHISSVHGYGSTLFLGWMVMCYNKVVIPNPKQSSIGYGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KRQ9</accession>
    <name>A0A922KRQ9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KRQ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="480" mass="56814" checksum="D9D87177403EFC8E" modified="2023-02-22" version="1">MIYCHHTRHSLCSDVFLNSNHSKKPFILIQDSVAKTHNATLLAMDRLCEILYNFLAIKIIKMARFLRIEKKNTISDIFQSDYYYVHFFLTRISYRLDEYEDHRIPMTYRRFKSAIFITLNGLCIIITLTLYVCMKESKILINYKYLEEIINIQRLDIIIICTLCMVCIGELISLRLLFKVVTYKSPMHDIVMKNLQFNDQRLTSNHLRYLHQYYLFLKTIGAILSVIIFLCIILGYVSEISLLVWSYFENKITFIQLLTFMTLFFSVCFHFDFMITALLLGTITAGFISEFLKLRSKQLSQFLQLNHLSKQIPMMKFKWNHIHQEYVDLYEKTAAIDKTISFVLLYLESASKIASISACIFYSRQIRMGISNSIVLCGMLLVFVYTSVLYTRLTYSPTYNHQYCQSLLKWMAKRSIIRNKTKKQFMNAMVKSNLFLQTMTQNEFGFHCGQVFFITKFQVLKLFMMHLPLITMFYKKICMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KRV3</accession>
    <name>A0A922KRV3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_015947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KRV3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9491216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="76" mass="9146" checksum="1A2DAEECDDF56356" modified="2023-02-22" version="1">MTDHYLEILMERSSHRIIKFLEMDVQQLKIFKLEKEITPRIDDLAFVRTEQKRQDWPIVEILEFNGTGRTAKVELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KTY1</accession>
    <name>A0A922KTY1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KTY1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="147" mass="16842" checksum="E08AB85CE67EFCD0" modified="2023-02-22" version="1">MSLMISSLQQQRQHSSSSSSISSTVVETKSNINLTNGINQRSIINRSKIEAIDDDDDDVIFVERIKKNIPLIILDDDDDIADQESKKTTIKRQKISHQNNILNVNTDLIKPDNQIEVNLNDDDGKQHPVQNSDPFCVRIEFYWKSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KUF2</accession>
    <name>A0A922KUF2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EIF3K</name>
        <name evidence="7" type="ORF">DERF_014484</name>
        <name evidence="6" type="ORF">HUG17_6680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7644318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KUF2"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000212">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="41"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7644318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9493751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="234" mass="27469" checksum="FD4C699FE9057A4E" modified="2023-02-22" version="1">MVGESKKDKIRDMLKGIELYNPNNLTILLQYLDEQCADNHYDLEANLTILRLYQFRMNTDFSEEELDKDVVKKVIIKILLKALTALPNTDFILCKSLIHPSLLEDEPEPDDELKHVLTLHQSLETCNFEEFWKVLRTVPAVYLNITGFEDSIRKFICYVVKITYQTMRKDLLGKILGGLDETQLKYWIKVNDWEEKEPEYVFISNQEELIKSKNIKEKIEFDNVARVVAAYAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KUY2</accession>
    <name>A0A922KUY2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium/potassium-transporting ATPase subunit beta-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ATP1B2</name>
        <name evidence="9" type="ORF">DERF_014730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KUY2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9494006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="365" mass="40632" checksum="78F61E81802FF800" modified="2023-02-22" version="1">MASSQTENGKKNESYPLKDMNSSSTKTDETTPLTKHNDDNNGGENNVGKEQTGLEEKLSSLEKDNEAANQNTKRTVINLGNVEEILQDQKIRVIIGIVGCVLLLLAIAVIITLLILNANNDDKTHRFLRIVPRPRGPTNLVYYRHGDLKKESGIRSWMEMVKEIDEFLAPYRRPINASLCAVNDRSSIPDDTVCLFDLNTIASECLKPDYGYMSGSPCIFIVFNNITDWMPNAGSNDTSDTTGVVELECTTNTQFDAENIGPMEFTPYQGFSSVFFPYKKQINYMAPFVALRLPSPTQNVGIGLTCRLLASNLQPSSSLQPPMPPPSTLLNQTTATVTNMITTAVDYDYYTQEPVPYLPFNIYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KW17</accession>
    <name>A0A922KW17_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_016017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KW17"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036803540" evidence="1">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="7227" checksum="ADA39F5D8D9FCEE1" modified="2023-02-22" version="1">MFFLVGWLIRWFATITNEIISIIEPRKKTDLFEIEILIEKLKYLENIELTPQNKTCAHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KWE6</accession>
    <name>A0A922KWE6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KWE6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7498" checksum="5846FA54F10751C5" modified="2023-02-22" version="1">MFVWLKTKNSILITPDSIDSDFYSIRSLILHSINEILYLYLMLINCILQNNNEAIMMIIDIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY09</accession>
    <name>A0A922KY09_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ARL1</name>
        <name evidence="10" type="ORF">DERF_013012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9496993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY09"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000306">
        <property type="entry name" value="ADP-ribosylation factor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="431"/>
            <end position="438"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="533"/>
            <end position="536"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9496993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="588" mass="68165" checksum="5A21704C814B056A" modified="2023-02-22" version="1">MNFNHQNSINCDIDRKSMMMMMMYDSSKCSKYIHFTPIAIYYYLIISCIILIQHVHTIESDRIPDMCEHESVYSAARIRFDDHFERYFLSNGHYYWLYNLNEQPPNEQMALKIPYNFEPDIAIVKDISKCSPNGYRSLLLIQMKITPNRQAEWFQLEMKINRWNSTTPIFWNEIQKIANCDLKTEICTATDSYFMTMAFDFKRKLDGAFGVIGDIAYFIQGDKVFKVLYKNQCIDNPYAQVIAYPGVFIGTTTTAALVEPGINDTIDVILFDHDVHYRIAGQESLADIQFTKNIAEPSYWRSNNPDYFKTCQHPNIMLGLNTFFQDLFTGSKRHYYLRRIILSIFFIIFIGIFLLAILLFIRNNRNQQQKHREGKQIVEKETQPKELEACLETNVNTADTGKTNVIYNMGNLLSYFKSLFGSREMRILILGLDGAGKTTILYRLQVGEVVTTIPTIGFNVEQVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAIIYVVDSSDRERIGISKQELVSMLEEEELKNAILVVLANKQDMENALSVAEVHRELGLDVLKNRTFQIFKTSAIKGDGLDEAMEWLSNSLTANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY82</accession>
    <name>A0A922KY82_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY82"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24036" checksum="B462B607BCEC3153" modified="2023-02-22" version="1">MATHTGTHMDAPNHFGGKDKWSIADIPLENLIERPLVIVDVVGQSQSQRDYQTTVDDLMEWEQKNGPIESGSVVIIRTGWSRFWPNKLDYFGTDTTDDKLAHFPGLHPLAARWLVGKEIVGVGIDGPSIDCGQCNDYMSHVILNENNIYILENLDQSIFDINPVGATLTVLPMRLSDSSGCPVRPIAQFSHDHHSMNDEFDFIKNTIVNLSMPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYE2</accession>
    <name>A0A922KYE2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYE2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032589">
        <property type="term" value="C:neuron projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000129">
        <property type="entry name" value="CLUMA_CG018772, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000533">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037448">
        <property type="entry name" value="Zig-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279:SF36">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE 9, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23279">
        <property type="entry name" value="DEFECTIVE PROBOSCIS EXTENSION RESPONSE DPR -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="331"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="423"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9505900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="596" mass="66020" checksum="CFD910985703F6B5" modified="2023-02-22" version="1">MTKKMSSKYRQRINIVDYHDDQQIHLPSIELYGKRQQQQQQQIFSSPSPSSLLSIDDTKIQSTTMTTATTTTKSLNSFLLNQNFHASSSVDNVNISSTATKNGDNEIVDKNSGYNCNGDFHMKKFFIHKVNYNDNDNESIENKTNLQTTTTTSPRAIMATKKLLTVSTFPSSSSSSSTNCQTKLQFQSPLPLPLPSTNSSSSSTLQSINCGQYRIAMSIIFILNILLIHHHIDSCNCSPSSSSSLSDNHRINDDNINHPIITDNKLATIRFVRSYSEEFMSSSEERERGLQFFGGTSAGGSSVALSSSTTLLSSSSSLQSSTSSAQKRISPYFDTESISTNVTISEGSSFVHLPCRVKQLGDRTLSWIRRQDFQILTVGTFTYTSDQRFQAIHRENSDDWSLQISYPRKKDAGIYECQISTMPKMSLFIQLNVVVSRAKIVEGPTLYLSSGSTLNLTCMVKDTPEPPDYIFWYYNGQVINYGSPRGIKVHTEKSAQTISKLIILKAQANDSGNYSCTPSNAEPAHIAVHIQNNANPAASIQHGKRSASREYGSNGCGHHHHQSSFSLIISISFISIAFMYLLSSSSSSMSWSFSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYK3</accession>
    <name>A0A922KYK3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_013436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYK3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="505" mass="58911" checksum="950D702B3F4CB251" modified="2023-02-22" version="1">MTQRFPYYNPTMPMIPEPPRVVPIQPWIQDDSIDMDRNHLTTTIHPCKDTLKQLRLKFGIITDNDNRMNPDDSLIENIKLIDLNNDNTTTKSTDNKCCRHNNNDLQNQLNKLQNNIRNQLIELQTSDDDDHEKCPGSTTPKQLLEYIRKQDERLTMINQKIDQLLQLQKSLTIEQQQQQIERSVQTTTTTTIHQKPNHHHLKKTSLSSEESPSLSSSSSMNSSTTQNYLDSSIEKMRKDLYDSVRLKRHHLQQTKVKQFLQSPPSNKLTTNNDDDRVEKVDEFNYTTMLSEVNSILVRNGSVSTSTPMSKPKRHQQRQQQHHPRQLLRTEQSIYIQRLASKYCMDDNVADNQTTKIDDDDDDDDEIVLESIRKSTRMNTVKMIKHVQPPSPKIDYQKFQTNYNRYALSDHNSSIATRNYMDKYGLYIETTMNKHRKSLNPKHNRYKSSILIEDVDDDDDDDEKYLDAKANVSNNTDLQNNRTPAPPPPPDRLIDLDLMKKLPKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZ07</accession>
    <name>A0A922KZ07_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenylate cyclase</fullName>
            <ecNumber evidence="4">4.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ADCY1</name>
        <name evidence="20" type="ORF">DERF_013747</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000001">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000002">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032628">
        <property type="entry name" value="AC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009398">
        <property type="entry name" value="Adcy_conserved_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF26">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16214">
        <property type="entry name" value="AC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06327">
        <property type="entry name" value="Adcy_cons_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="804"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="339"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="19">
        <location>
            <begin position="921"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1124"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1384"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1473"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1689"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1764"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2003"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1127"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1399"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1473"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1695"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1793"/>
            <end position="1805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH9497788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2070" mass="236951" checksum="23A90332048D4C2B" modified="2023-02-22" version="1">MDHSVKVMHTHRKIAFSRLWIFQQRRFENQELEQLYQRYIFKLQQTSIVSALLLLSLLSISIALLQFYYIQHTVTLIGIYSLIQSVIFLLLFLSSFRMHDTQLLALCYVIIFFCILFCLLLSPIDNNLHYLWKLLIKWSSSSSSSIDNDTATLISQQKPSDGLWAIVFVIFLTYTMLPIKILISFMFGLCISITHLSITIINLSIISITTTTTTNTSSIIAVHENFIHKQMLEIYERKSSGSIKLGTRIIANALIFLAVNFIGLFTNNLMERAGRKAFLDTRNCINARLDMEDENEKLERLLLSVLPQHVAMEMKADILSPRELGQFHKIYIQKHENVSIVFADIVGFTVLASQCTAQELVRLLNELFGRFDQLANDNHCLRIKILGDCYYCVSGLPDPRSDHANCAVEMGLDMIDTIASVVEATDVNLNMRVGIHSGRVLCGVLGLRKWQYDVWSNDVTLANQMEAGGVPGRVHITQSTLDCLHNEYEVQDGNGSERNSYLREKNVKTYFIIPPQQRRKHFLFNTLHVRHLAGSKRKLSFKNVSNVVIQLLHSIKYSIDVPFANMAMLGNNNCCSSINNNNNNNNNSNNNNLTLSTGIGGNEITFNKKFQGTDDNNFRKPFKKRHSIIYHQQNATTNRVNKYLSQAIEARSVDQEKSTHVNLLTLCFKDEQKERQYGEEKDRGYLIALVCSLILLCLLTALEFIILSKQCIKWDISKVFLVRLSTIISSIVFIYSIAQINVYTCLDDMACNYQNHTLIIDPQFIEMPEFSRLCPYPQYIIMSCVVSFFSLVIFLRLQMLFKAILLIPMAIVYILLIEYTHFKLFECIYEYDVPLHVTGPLIILHFVLAILLHGRQVEWTARLDFLWNSQANDEKTEMLELQNSNRRILFNLLPSHVATHFLDNQFRNNMDLYHQSYAKVGVCFASIPNFMEFYVELDGNNQGVECLRLLNEIIADFDELLDQEKYKPIDKIKTVGSCYMAAIGLIPQYRIPENDTVYAAENMSCLVDVVFDMKDRLAEINDNSYNNFMLRVGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGLPNHIQCTEEVYQLLKDYPYEFKCRGTVNVKGKGEMTTYFLLHKKSNHKPFKAIRPSNIDASKSGQNGSTTTTTTTTNNFKVKSQQQQPNNQFFPSSNNASHSTINIVENSVSENQQSNVEHSPNKTFMDRLHASAKSSRQHKDQRLSVIGESLPYIIRDKESNLFQRSQGNHHLCYNEPKPIILGKSPDKCRLMVKENSWESSEPITNNNNNNNPRGIELNPTTIKTLLIGTNIIEKTNPNDLFTGDDSGKKLQHNFYFDDDALSNIKSQAIEREKQRNIFSPAMSRCTAFSVADSTKATIESAESLNKLLVDGDDDVDDVGKNRQQDESSSIYNISSNSSNQSCQYGQIIKKNYTKECIENNFYNNDNNRSRNLAIKSFQNNNKKRNLFNIDFPMDDLVYRNYRNDDDNNRQKSIENNQQQRIHHHQQNAMKRMSYQHFIGGQEPTKSYFAQQQRNQRHYQAHNSPLIVHRFYHIDSGPDNIGQRQSSSSPLLMNSCVNNNDKANFQSDNRKIVKCKPMENQLNRYHLSDKNFNYKQQEQPQFSISNESDDNSSSEDDMNSVAALVGNNNNKYTAAASGNQKLNQQQQRFNLTMANNSNDQYGKIRKKLSSMENVGQSIDNNPQQNRIFSPSSNSSQSMDCSQVSNLIYDNDQFKPPKCLNVDEMNKINRRFDRIRNPTNETVSHFDDNANLISSSIPNYSPDDDSDNHRNVSFIENTRPDYESDDSYYAEDENDDHVNNNNNNNFSPINRHQFISDNESNSKHRTSKTHDCSMDVTLLEQSMATTTNATETFAANNENLTEDDGGYLDNGAISDLNSMFNECPDSRMEDFDRDFEPFRHNNHSFIRPLRSIEDILLNDCDDGESMISIDKSSSVHETTDCTSEFLYDSDAAFNQQATGFIDTSTSNIISNNNNHDKLLVTDLDSLESHFGLPLLQNDNQPIDDNRLSPSSSKHHHDSKCSFDINMNHHHNNNNNNNQTIHSDIVMANNHQDENRNEINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZ65</accession>
    <name>A0A922KZ65_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_013848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZ65"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9497908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31899" checksum="93A82525BF602EA7" modified="2023-02-22" version="1">MKIILFLIQLIVGAIGISTWIFGCCMMFYVVWSLNTITNIQSFSIGDSLITNGQLIFGIILSTVGLLIIYSSWKKNLHTLRLCIFLTVLSISMEIGTFISLKVANVSISNIVDQGWKEMNNQSKNFIQKELKCCGLTGLSEFASKLDPIDQSCYYQRQMETDSKYKFSSSSLSSYEPYRTGCKQKLIDWLRKQRKIFIISTCLLLAIQVILSIILMLILLKLLQQQNEQLEHEQRFKRQSNIMMIIDDENESPSSPSSTSTTPSSLIFGNKQQKILLQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0D7</accession>
    <name>A0A922L0D7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0D7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="120" mass="14100" checksum="A46B0D5AA396857A" modified="2023-02-22" version="1">MDSSPATNRRILKRNYLKSKHMLAKLNKWNFEFDSSSLIIIDNNTPIQLPDHHECFKSTAKHFHSNYHHKWWSSIRRSSSTSTSLFLLLLMAILIFIICPLPFVNFFANRQNVNDTLLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L175</accession>
    <name>A0A922L175_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009737</name>
        <name evidence="2" type="ORF">HUG17_7579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L175"/>
    <dbReference type="OrthoDB" id="10645914at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324739" evidence="1">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7637373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="234" mass="20986" checksum="C6FF7FD18C3F24BD" modified="2023-02-22" version="1">MKLQLIVLGVALFACAVMAQEMEDNLIADASEMDLAVAESAGAGAVAGGAAGAGAKGAKAGAAGFKAGAKAGAAAGAKGGKKGAFAAGAAGGAAGVKKGGKAGAAGAAFAKGAKFGKAGKFGKVGGAGFNKKFGAIKTFGMAQGFKFGKAGGAFAAGGAAGAAGKKGGKFAAGGVVAGKKGGKKGAKGAAAAGFAKGGKKGGVAGKVAGAKAGAAGAKGAFKKGFAKGGKGIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L254</accession>
    <name>A0A922L254_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Moesin/ezrin/radixin homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_010046</name>
        <name evidence="12" type="ORF">HUG17_0092</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell projection</location>
            <location evidence="8">Rhabdomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L254"/>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098592">
        <property type="term" value="C:cytoplasmic side of apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042051">
        <property type="term" value="P:compound eye photoreceptor development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010669">
        <property type="term" value="P:epithelial structure maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007315">
        <property type="term" value="P:pole plasm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006403">
        <property type="term" value="P:RNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13194">
        <property type="entry name" value="FERM_C_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17187">
        <property type="entry name" value="FERM_F1_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000003">
        <property type="entry name" value="Radixin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000002">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000013">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.450:FF:000001">
        <property type="entry name" value="radixin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041789">
        <property type="entry name" value="ERM_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046810">
        <property type="entry name" value="ERM_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20492">
        <property type="entry name" value="ERM_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002305">
        <property type="entry name" value="ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="11">
        <location>
            <begin position="5"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="302"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)</name>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)</name>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7644554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9511597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="575" mass="68429" checksum="021F7B51962E70CE" modified="2023-02-22" version="1">MPRAINVRVTTMDAELEFAIQPSTTGKQLFDQVVKTIGLREIWFFGLQYTDSKTYTTWLKLNKKVMSQDVKKDNPLQFKFRAKFFPEDVQDEIIQDITLRLFYLQVKNAILSDEIYCPPETCVLLASYAVQAKYGDYNPEVHQDNCLQNDRLLPQRVADQHKLTREEWEKRITEWWQEHGGMAREDAMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEKDNKLTPKIGFPWSEIRNISFNDKRFVIKPIDKKSPDFVFIAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKSVKKQEREKLMKEMKAREMAEKKQQEYEDRIRQMQEEIERRERILTEAQETIRQLEEQLRRVQLAKEDMERRSKELEELYSKLAESKQMEQAEREKLEEEVRAKQAEYERVQEEVRAKEEETKRLQIEVDEARKRQEQSKANLAAVTETPQNHHVFENDHEENDDELTNGDVEVHFNGDADSAIDVPRPEEDRTTAVSKKKDLQEQLKQLSKDLALNKDDTKVTANDRLHQENVKMGRDKYKTLREIRKGNTMRRVDYFENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L281</accession>
    <name>A0A922L281_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L281"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9515833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="9977" checksum="F72DAADF9DCDFECD" modified="2023-02-22" version="1">MDMGHKTCIEKNSFDKEKIACFKFRIPNNSCNQQQQPKTAQTMKCETCQRCLNIFNMQIAYVLLDIQYMVISYSYLPETILPNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2C9</accession>
    <name>A0A922L2C9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2C9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7450" checksum="F6738AB4FC7D4C95" modified="2023-02-22" version="1" fragment="single">LYWLRYKNIKISFLSIKNTGKSLPLVEPQPTKKTNQSLIWPKKTSQKRMNSNQWPMHKNNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3A3</accession>
    <name>A0A922L3A3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CSNK1G2_2</name>
        <name evidence="3" type="ORF">DERF_007089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3A3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9516341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="307" mass="35139" checksum="752223885CC29AC7" modified="2023-02-22" version="1">MATSQDTSSDSAILVNQRVGNSNFTIGFYVTGGSFGSLYIGTNNETGEKVAIKVERADIDKPQLPLEYGFYKTLGNYMIFIPKIHYFGPCKNYSALVMDLLGPSLLKMNQICGGHFGLVTTTKLMIQMLNIFEYIHSQGIIYRDVKPDNFLFGQPNTSKWATVHMIDLGFCKRYINEDNRHISYVEGKGVTGTARYISVNNHVGRELSRRDDLEAIIYMIIFLHKGQLPWQGLNVADLRERTKQIGIIKMTTTSKELCSNMPVEYENFLEIIISQFRYVLFRMGITADDNYYDWDQSHQPRSENKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4H1</accession>
    <name>A0A922L4H1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_007426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4H1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9516700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="466" mass="55376" checksum="4606262FB5B162AC" modified="2023-02-22" version="1">MSSEWESRNFSPRRYNLFNNKIEDSKFTCLGCRYVRYCCKECQEQSIDIHQPECHVIGKRPLRTMTRMILRILNKTNAVNQKLKRGIILTIEELIRIYGKILINSFAITDQNSGSVIGRALYLGASIFDHSCCPDLYYQFDGLKIYFIASRDIILRVSNMIEEISDTNDEDGAQDVNQLYISYIDEILPVWERQRILKSGYYFECRCTRCQDDLQRLPSINNEPRLSQCLEMIEDYFESDHCYELIQMAVDYFKYNETHPNFLIPDDILHRKYLIQTNPELFSIKQRIEALIQHHRQQKEYSSHQMLLEQCRLILTNGCALDLATILRIKDFISCHECDSEELEQILQIYSQYYGNHKHPRILRRIWFWLGILLLDKFSSPQSSKIIEKSIINSNILLSLHRRTKLIKSYLRFKFKFNFPSTYIQLPKRRIFCCAHDKHEIKWPQSNKTQSIVRSQQSQQSGNCFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5K5</accession>
    <name>A0A922L5K5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BLOC-1-related complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_009333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5K5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032143">
        <property type="entry name" value="BORCS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31397:SF1">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31397">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 7 BORSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16088">
        <property type="entry name" value="BORCS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9510833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="101" mass="11704" checksum="01E1DD8F0500A16D" modified="2023-02-22" version="1">MSQQMQQFTFIQQQRSLYEDSRIKLCEKMTQNVHNVGSLCRQIIKSSRTNDILAHSAKNFATQIDVQINAGETNLKKWHSTMTNLNEQLNQIEHIVAEQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L647</accession>
    <name>A0A922L647_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Potassium voltage-gated channel sub D member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">KCND2</name>
        <name evidence="11" type="ORF">DERF_004353</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L647"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024587">
        <property type="entry name" value="K_chnl_volt-dep_Kv4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF105">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11879">
        <property type="entry name" value="DUF3399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent Kv4 C-terminal" evidence="10">
        <location>
            <begin position="95"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9520658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="364" mass="39726" checksum="402A789A57EE3282" modified="2023-02-22" version="1">MVPATITGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQKKARMARIRIAKATSGAAFLSKKKETEARLAAQENNSNENGATSEDIFELQHHHLLQCLERTTDREFVELDAPFNGQPNRLSSTPPISPVTSIAIVPTKNSFRRFLGSCCKKSGENYEKHDAIEQEELSPLSTNNNNNPNMEDSSESSGKLKQQQQHSQTYPFGSTSANEKQQQQQQPQQQQQQQQSPQSTSNIGHSKISNTPSTTKTTKPNTSQINVSTVVHVQNENNNTKPATTTATIIGHPQLPSSDNSLKTSMTQSENNNNIINQRGPSTNLTTTTTATTTTTSISDDPINIPSTSSGHTELTVVRISKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6H8</accession>
    <name>A0A922L6H8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6H8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="150" mass="17467" checksum="D044D270668E8266" modified="2023-02-22" version="1">MEVVEPYRGYCPNFLVQKFESKYGPISKYSKIEGVVFGTFFAIISDFKIINFMYSVDNFTICSSDYRWTGSANTLKCISAGVQLKIKEKLRGERIVFGTFFAIISDFKIINFILSSSYKNNINIDIKILYIHCYRHQLYPQVPHQDQQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L742</accession>
    <name>A0A922L742_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Damaged DNA binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">XRCC1</name>
        <name evidence="8" type="ORF">DERF_005907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L742"/>
    <dbReference type="OrthoDB" id="25840at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17725">
        <property type="entry name" value="BRCT_XRCC1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000008">
        <property type="entry name" value="X-ray repair cross complementing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045080">
        <property type="entry name" value="BRCT_XRCC1_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002706">
        <property type="entry name" value="Xrcc1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370:SF5">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370">
        <property type="entry name" value="DNA-REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01834">
        <property type="entry name" value="XRCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="320"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9522324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="514" mass="59246" checksum="F32FC186C8C1C1EC" modified="2023-02-22" version="1">MSSLIKLSSIKSFSSESHKYPSRNLLNIVDDNNDSSPSSWKCKHWSDYCWIIIELCEQAIIDMIEIKNDCSAFIEIFSSTTGDSNDFKVLLPVFSSQLPSNCRKQSFNNQNERFKFTTKQFMSTSRSLPCKFIKCVCSQPYNKNICYGIASIKIYGQQFQEHKNSDSADAVHDVDDDDDDGKKKPLWMKKFKFFDNKLTMVDDEYFAMNFDHSKLKQQHQKQQQQSNSNVTTIDSNKQNIDSKMSSLSKLSAEIKPNLKTLPLNDDDGNNKNVNVIEQLSKPSTSTSSTKAGKKRNHNDDDVQQQQSSIKIKPTKKIKKPFEKLFDNVVFVLSGYQNPIRMELKQKALAMGAHYKPEWNSNCTHLICAFENTPKYRQVNHLGGKIVREQWINDSYDQRKRLSWRNYLLGKFIGNDDDNDSDDVDDKDFNGRNNKATHNNNTNSININRTKNRKDDGQNFTDEQRPYINNKQTAATSMKMVMETNKKNIVANADYDSDIIYDLETEDDDDDDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7Q7</accession>
    <name>A0A922L7Q7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_007198</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7Q7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF403">
        <property type="entry name" value="CYTOCHROME P450 306A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9516462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="488" mass="57332" checksum="6DDE84DF67E8BCEB" modified="2023-02-22" version="1">MLWSISTYITSNLSSIVLILLFLRYLVSLNKDKRLPKGPSGFPLLGYLPFLGKNPHHTLWKLGEQYGSIYTLPLGEQKIVILNDWDSVRNALRKDSFLGRPDVSMFSLVTGVKSLIDDNHSSWREDRRFFETIFKTCFDSPNIFKNLVNELKSLLIYLKRSNGTPIESRKNTTKYVNNFFYSFIFGRHYISSKSLFDSALFLRISILSLYPSWIAKTFYKLFVMFNHHHFTLFAKFFKNEAKNHFKSMRNESSIRDLIDYYILEMQAKKTNYTSTTMSIDKLRANCQVFLSFGCEAFISSFEWSLISMAYFTEYQQVMFKEIEKTIGLQRIPDFKDEIRMPFTTAFLNEVFRWKTVLPFNFTRRSTDDATILGHFIPKDTLVVANIWAVHHDSAIWEHPFRFNPYRFLTDDGKTMIGDHEGFMPFSLGKRSCVAETFVKKWLFIYIVVILQNFSISSPSGEEAFDEVYHLTVRPKKDVQLTFQWRNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L891</accession>
    <name>A0A922L891_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L891"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8662" checksum="80F8C7FB68784361" modified="2023-02-22" version="1">MSSYSKNVNENETLSTFRPSSLYLFFPRSVQSKNHHHHHRQQQQHIIGLIFIADLSADLTMLLAIHTQQYCHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8P5</accession>
    <name>A0A922L8P5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein six2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SIX2</name>
        <name evidence="11" type="ORF">DERF_001468</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8P5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000063">
        <property type="entry name" value="SIX homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF61">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="330"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="332"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="548"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9527456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="662" mass="70070" checksum="756851267A61BD8E" modified="2023-02-22" version="1">MTTIADASLPSTTTALSSSIQQQQQQQQFTVGSLSSMAGLDLSGHNNNHHHNNTIHHVHHTPSTSTTAAASAATTTTTTIHNLSSLSPSSSSSSKSSSPLSSTSSKSLPSTIITATIKQNTISPTLKTTLTNSIGLIGATTSFSSLSSPPLSIINNSTGIISGLITGNNQNHFDHHQQQLHHLNNSLSLSSSSSSTTTTTAMPSSLSPTILLPTLGFTQEQVACVCEVLQQSGNIERLGRFLWSLPACEPLHKNESVLKAKALVAFHRGNFKELYKILESHNYSPNSHPKLQSLWLKAHYIEAERARGRPLGAVGKYRIRRKFPLPRTIWDGEETSYCFKEKSRNVLREWYSQNPYPSPREKRDLSDATGLTTTQVSNWFKNRRQRDRAAEAKDTDSNDKHNIGKNSVKVTNDSSHSGGDSTDDEFEEGNSERTSSSNEMNSTTTATANNNLTPSTTLLNLNGTNGTSPELSAFSALANHLNNTATVNIGTNGLIDSGGGGGTSITGTGGGGVSNSFSANLGSQSALSAVTSMSSAMGYPHSAFRFGSHHHTHHHHPHHPTTQSHFSHHTLHHAAAAAAAAGSTTGHHHHLADVAPSALVMHHAAAGAVTNAETMFQLSSVLSSSAAASLAANPSAFDSYSKYGASMAAAVAAFSGAARPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8U8</accession>
    <name>A0A922L8U8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rac GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RACGAP1_1</name>
        <name evidence="4" type="ORF">DERF_001644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8U8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097149">
        <property type="term" value="C:centralspindlin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46199:SF3">
        <property type="entry name" value="RAC GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="2">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="264"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9527636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="460" mass="52549" checksum="7BCD6B548CA4994A" modified="2023-02-22" version="1">MNRDIKRQYTNKLLEDLDIVFGHILSNRKDLLSATNSLLDSYETLLSGDYPVSFGNSDGKQSVLLKSIIELRNELNNFQPETNGYRDSLIGIRTKISNLATEIDIALRDGGGQSDNSTDELAPDQVENGDNMITNEQSRQSEFDDQLLSDSIPTTSSLKVNRKDFEPSLSVSPVAFVSDDCHKPNSSESATNIGQNVMTKFHHFELFQNKLQFSKCYLCNNTILPLKTYQKCTKCDFILDQNCHQKIKVEWSILACKPILKKKFALNSNAIVLLKKCFCQIEQRGIEHRYLYTTNNNDQEACKLLDKYLGPSNSAIAISKLNINTICAMVINMLKRLDDSLIPSHQWNDLPNFPVCNQWSNEEKVRYVEESISNGIAAIHRYALAMFMIHVKHLLVRNYSSHISKQILMDVFAKHLIRCPDVSENDNKQMQIKIFNVQADIMSALLNINIDFWKRCCEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L962</accession>
    <name>A0A922L962_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">COX10</name>
        <name evidence="15" type="ORF">DERF_001220</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L962"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9527184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="450" mass="50400" checksum="2445C82AB7EA3009" modified="2023-02-22" version="1">MFKLFGKIGSSSKFGHHQNVGNKFSIISTNYPSFMIGCNHHHHHHHRNQNFTSILILRHHNGPANNKTASNLRFLSSIQQQTKLIHSDDESTTTTSATATAEDLLPKPSSSSSSAIIEYDEHRFRELSKEFSKSLDKNQLTNIENVWKDIQPSTISNVLNDYSKLAKIKLTGLVVLTTMAGFYMAIESSVNPTILASTLIGTALTSGSAAAWNHFLEVPFDSQMRRTQARPLVQGSLTPLHAATFATITGVAGLSILATYVNPLTALLGGINLCLYSFMYTPMKRVHIVNTWIGAIVGAIPPIMGFTAVNNFIDLPSLLLGLILYSWQFPHFNALSWNMRHEYARAGYRMMSVTNPRLCQQTALRHSTLLLGYTAAMCATDMTHWSFGIDSLPFSLYLVYLSYRFQREPSSQTSRKLFLYSLIYLPVIMLLMVISKNRKSSRNQERKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9E6</accession>
    <name>A0A922L9E6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitogen-activated protein kinase binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">WDR62</name>
        <name evidence="5" type="ORF">DERF_001450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056162">
        <property type="entry name" value="WD40_MABP1-WDR62_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24782">
        <property type="entry name" value="WD40_MABP1-WDR62_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037134371" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="103"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="MABP1/WDR62 second WD40" evidence="4">
        <location>
            <begin position="369"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="667"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="709"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="866"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="964"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1043"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1403"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1640"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="866"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1090"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1421"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1450"/>
            <end position="1468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9527439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1733" mass="193380" checksum="9D2CF20CA5DA1F25" modified="2023-02-22" version="1">MASIIKFLMFSVRLDRVLGLTVSNNASLDCDLYSGTVVYTSGCVLVLYNQRKNKQFHIINSLKKPITCCKFSKDGKYIVTGECGHQPQCRIWEVSTGEQVACLSGHKYGINCVAFSPDGKYVVSIGSQHDMMVNVWDWKTNHVVASNKVSVKVKSISFSDNGNYFVTVGNRHVKFWYLEYNDIANKNKFESLPLMGRNAILGDQRNNYFCDVACSRGDSNSNLESTYAITKSGLLCEFNNRRLLNKWVELKTESANCLTISHNYICVGCAQGVIRCFRPRTLEFVCSLPRPHQLGIDIAKGFTSRNEMNSIAKMSMMKPKYSDTIAVVYDDYNKVVTAVYSDRSIYFWSLNDIKRIGKLNSFLYHSSCIWDIDVYPYNSKSSRHLLPPGTFLTCSSDDTIRIWNTEMDMNSSKASNYIYKKNFFSPELMKILYMDPDLNYLCDQDLVQTKSNSNGNGSMQSSDQYDSKNGIRAIKFSTDGKHLASGSILDFYNSFQMINAVFILGDRCGNIRIFDLEMQKDLFKIEAHDGEVLCLEYSNEEACGRSLLVSASRDRFIHIYDVHRQYSCIQNIDDHSSSITSVKFVCSKPNPMNLKLISCGADKSLIFRKQTDPESDFRLEHHVAGKCTFFDMAVDQKKNHIITASQDRLIRTYDVWTGKNVNNFKGSLGEDGALIKIAFDPSITFIATSCTDKSIYIYDYQTGECLATTSGHSEIVTGLKFSLDGRNLISVSGDGCIFIWRLPVEMTNAIASKLGLPLISDSCHTTTITNRSLNIPIQNELIGNNGTADVPSVYHRFDVSTLPTWVRKQMFEENREKYSNNNSMNVDKEFSKTLPRGRWAHRFVEEGHEMNPGLVKAYANNFETMASRSTPTTPSGINSPSIKDSIRQNNRLSMIITRDHPRTKSSLSSGVEDDDDDRNTTDSDNTYSHDSSYKVNKVSNDRPRSCKVSDTYSMVSSISMANINDVPYDDDEGSTIETSKNKDDKNRYNSLYMSTENLERIDQRNRYLKNVFENIDKSNIDNNSASDDSGINQIDHSLSSNSTLVNHHHHHHSVSPPQPNVRQSLSSRSSLNNKITSPPNGKDNHHHYNETTSDDATLSDITDINQDPSSSPDGLTTTTTITTNNDSTKFSLLDTINETSISSPTITNEEDDKDISKMDSNTNTIITHMDSKTSTTTTTTTTSKTNNISSSVTTTLVDTTSKDNVKSTPTQQPFMSKKREELAKTLSEAKKRLQSVGSTPSLTNSRSVANLRALTLFSTPDDENSIVRHRNRGSDLTSGDDDDENSYHTVDAFRKSISLSDLSRSSCTLPRKLSIYRANNNSATATSMNNYQFAPLWDQRRVGSTAGSLSRTPSTNTLNKVDMMRSQSTLCRQGLWNAVNQSPAPPSTPLSVAHPVNPAIAHLKPPMSTVSPTGMIINPRSGRSSAPPSQFRKSAATISCASSSRRGDSTEDDEEIDGSAINSDDDNSDEHRAIRPRPVTPPKPNILKQIRRSSNSNGGPMMSTVNVSMNPYQNHHYVQNPHQPITQSARPRRLWSADTMRSSKSEFNLASIGRDTPVRRRNNSGVSAVSLDLCQHLVNEMNFLTNYASRIHERASYSENTAIVDYLKETLGQVSRDIQAIVGLSPNKPTIPNKPDIVINNNDNGGLKQTNGNHDKNNSLTTAASHSQNNHIPDPQTQEMFQQFMAFLKMTKGGSSTPSTTTINGQCQNTQQQSTSNIVNNNNVNHNNNVNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9Q2</accession>
    <name>A0A922L9Q2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticular protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_008897</name>
        <name evidence="4" type="ORF">HUG17_4753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9Q2"/>
    <dbReference type="OrthoDB" id="8021718at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038277022" evidence="3">
        <location>
            <begin position="16"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7641708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9518307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="186" mass="19791" checksum="71D118FF681DF74E" modified="2023-02-22" version="1">MKFLIVFGFVAAVGAMPYHGLVNTGASAVQRHDDGHGNYAFGYNEDHAYGGTFRKEKGGPGYQVGSYGLRDADGRMRIVEYIADAHGFRASISTNEPGTDPKQDPAATSLTFGGHAPGPVPMAPIMEHGPVLAAAPVYAAEPVYAKTLALPMAGSYSVQHASYLPAMANHYYPEPMMAGHYNVGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA71</accession>
    <name>A0A922LA71_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_000445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA71"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20833">
        <property type="entry name" value="C1_cPKC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04026">
        <property type="entry name" value="C2_PKC_alpha_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000006">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968:SF14">
        <property type="entry name" value="PROTEIN KINASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22968">
        <property type="entry name" value="PROTEIN KINASE C, MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="59"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="207"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9526347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="43842" checksum="A199ED79D9E2FFF9" modified="2023-02-22" version="1" fragment="single">MSNNRNHSPSSSLSNTLTSEFTTSESDDGSSTNSWNSNSLRPFQRNGAFKKKEYSLVLDHRFHPRYFKQPTFCSHCREFIWGFLNKQGYQCEVCSLVVHKRCHELVTFKCPGADKVIDTDPRKVHQFQLHTYATPTFCDHCGSMLYGLYKQGYQCRSCLMNFHKRCRSNVPNLCGCDAVEKRGRIELRIQVNTFDDDNNDNNDFHFENNNKNLSVNVNNDSKMVICCDIRKAKNLCIMDPNGLSDPYVKVRLLSSNQQSLNNNRSSMTKYKTKIIRNTLNPEWNERICIEIGPQDRDKRLLISVWDWDRTSRNDFIGSLSFGVSELMKQSVEGWYKLLNQEEGAYYNEPLPPPGENLIDYLQKLHINVQQEQQIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCU8</accession>
    <name>A0A922LCU8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyldiphosphatase 1</fullName>
            <ecNumber evidence="5">3.6.1.43</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">BCS1-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Dolichyl pyrophosphate phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Mitochondrial chaperone BCS1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BCS1L</name>
        <name evidence="25" type="ORF">DERF_001139</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Derf</strain>
            <tissue evidence="25">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Derf</strain>
            <tissue evidence="25">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="ELMO" evidence="24">
        <location>
            <begin position="637"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="602"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="602"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAH9527095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1434" mass="165481" checksum="E8187C657E3C9870" modified="2023-02-22" version="1">MSEEWKTLSLTLVVYPKGDLYGNFLAFVSLLPFAIIIAFFTLTIFVRDIHVILFFIGQLINEAINYLLKNHVQADRPANKFRDQFTSSGSSSSSSYGWPSSHCQFMAFFVTYSSFCVCFRLSRLKPYWFCFMLICIDLISFAFVFHSRTYLLYHHVHQCIHGAMIGTIMAIIWYALVQFIFEPIIHHYVINSSINQFFGLCSIYLPLDDGQQKHYKYRKDNSGAGGGGNSLIKFAIQLHPELKDENKSSDKLNWFLYQLPKGQKTSIQSIIDYSREFWNLDPKKEYSLIMTLDETQHLFRFITEEHQYRSCFTQGAVIELYYSVRYVVSKLLEEFQQSLREWTCQDRLPLLKKICVYASDQAFVAEFDEQKGFQLLITSFVANKFNEFELHYILDIIAKIMEHDIIRWFGQTAVIEKNFIERIIELISSNRFMILVQPSQQQQQQQSNHLSMSAPMIPDAERRILILSLSILESAILNAAKLFLPIIREQLPIKKLSLLLEHEKYPDIQQNVLALINAIIQNLDPSKRRDQFRIFKETILRYVTDNGSEITHQLYVLQTLLLRSYDEQLTKVATPEQTNEKWREIRRNYDSEMDNLIKNQFNTNSTTTTTTANQSSNTSTGSGLNRSNSTVSNKSNTFNDTLLMLNNNETIDRFGLLPSKPNGSPATPAEIFIDPPGLWILNLLCYYSGKHNESFVRFIMANQSSSGETRPYDCPLIIASFRILSLIVKLLGIGKPPRDEGHEFYPMLLKHEEPLEEFFSIGLSLFNRTWHEIHATFNDLDIACDFLAEKFHKILANPNATVSFENFQKELSKISYTEISHRWREERLKREQRKEEMPAIQELKRLLLPEMTTIVRQNRLNYLVRGTRFDKYTAKGQRLKDKFWYCRLSPNHKTLLYGDVDEDCKNLDEKLTSKFDIADAGRLVVGKECPHMRDSKGKKTTMSLAFALIPRDDDSINGQQPQPLCFVAGKPEIFDYWIDGLNSLLQQDMTSNETKKDVEMLLDLDVKLRLLDIEGLNIPDQAPELPPSPPDYDFEYRPQHHTIGLTAALAAGRKAAIIAWAGVRRYAFVTCEVNSKDKSYQWILEWITRQSYRTQHVSMCTEFYEDEAGRISTRFAYIPSPGIHFFRYRGAIFRCERVREQMDALAGRPYEVVTLTTLGRDKSIFSYIFDEARTIALAEAANKTATYVPFGHEWRVFGQARSKRPIDSVILDDGVAETLVNDVERFLSSAEWYHKRGIPYRRGYLLHGPPGSGKSSFIFALAGHLNYSICVLNLSDPSLTDDRLLHLVNTAPKDSLVLLEDIDCSVRPRTDDGHPERWEGLSRVTYSGLLNTLDGVVGSDARILMMTTNHLKLLDDTLTRPGRVDVKMLIDDASDRQLKRAFLRFFPTTSSSDGDEFVRHVRRTYPRPISMARIQAHFLLNRDDPKSALEQPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LD98</accession>
    <name>A0A922LD98_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Calcium/calmodulin-dependent protein kinase type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CAMK1_2</name>
        <name evidence="17" type="ORF">DERF_002308</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LD98"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="17" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="16">
        <location>
            <begin position="78"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9528355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="382" mass="44911" checksum="E404B56575356644" modified="2023-02-22" version="1">MTADNENGHCNRVVSKSKPNPPPEMANSTIDDKCPSSYCMEIVWRNIFLMIILHVASVYGGYLGIFHARYRTVMFNYLYLILTGLGITAGAHRLWAHRSYEATTTLRIILMLFNCGALQNDILEWSRDHRVHHKFSETDADPHNSRRGFFFAHIGWLLCRKHPEVKNKGRTVSLKDIADDPVVQFQRRYYKPLATLFTFILPSIIPCACWNEDPIISIFASMTRYTLLLHATWLVNSAAHLWGNRPYDNGIQPVECKLVEIVALGEGYHNYHHIFPFDYSASEMTWLNDINFTTMTIDFLSWLGMVKNRKKVDHQTVAKRVQRTGNIQLYGLYQQQHQRSWWRHTPLTIMFMLFSPILALYIYRRFISYLYYLYFHIENRWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HGW4</accession>
    <name>A0A922HGW4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHD finger protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PHF14</name>
        <name evidence="9" type="ORF">DERF_014162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HGW4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15561">
        <property type="entry name" value="PHD1_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15562">
        <property type="entry name" value="PHD2_PHF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF150">
        <property type="entry name" value="PHD FINGER PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="197"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="609"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="548"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="688"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="839"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="880"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="952"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1014"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="450"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="579"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="771"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="814"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="850"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1014"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1046"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9493414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1072" mass="120049" checksum="892CD698BD8457D5" modified="2023-02-22" version="1">MNSKSTINHNNNNNKNSKKSNKSKSQTSKVLQNENHDDDGDSSSSSSSNETDDSDSDDDDDGSDEDEESSSEDDDEEDDENINGSKLKTKNKLLNQSSSKLSPKSSQRDHHATNSNSQSTNDIEMANNYRKILICSVCLGEQSLADDELVECDACGITVHELCYGIQADDTESIHSNASSASTEPWFCDPCKAGVRQPLCELCPTQGGIYKITDNGRWVHMVCALYTQGVTFADPEKFRGPNLSHIQFNHWGSKICMLCEDENFAQTGVCIRCDAGFCKTNFHVTCAQRQGLLTEIRSTEPGEMLDPYIAYCRLHSERQMAKKKRQNYLALLARHRYLLKQQHSNRRIEDSITNGRTLNKLFIQREKFRRNFQSIGNTQNVLTKRTPRLLDASPSAMRRLMNRCELAGFSIGRESFLIQEEMNDICRKWYIPPAFSIEYVSYYHDRNRRVAKMQEQSHELIEENKRLNDIEAKQFAKYNKLLKKHEQLKTSNELLRQKIRRYLAALSWFRPPPPQSSKTANLINDEMRRIKLLKIGQQIMSLPEMLNTNDEQQQQQKQNSNGLANANDNGANTSSTALNKSFNGKNSSASGSKSSKSITTTNIVNEFQMKKCATCKKSKEPHMMALCDSCNLYYHLHCLDPPLRRMPKKTRFGGWQCSNCTENEEQQTNDDVIEIDDDDNEDVVDQQANNKCNGTMSTSTNDDSMADTSQQQSSSTTKNNMVKKTRRGLRENPKMVTKYADYDESSNPALSSSNRKRQNKKRSILSPPPSQSISASPSPVAAAAAVVENSSSSNSINNSIRRGRKYKPPPPPSNTLESSSSSPVPTTIIPVAKATTPTTVTKCSASHQNSSPSSTKSLLSSQSTTTSIAAIPSTTTITTTPTTVTVGRKRKQTEASSILLNTSNSSNNIVDQSKSVKKTRQHDGRLCNKNEKSKQQQQVIVKKEIIDTNDNVVSSDSSSIEQSALTIDDNPCRNSNETTIPQPTTAATIAATVDDISTVLNDIILLEEEEAQNQQQQQKQQQRQPKIKQEIDTTTITVKDEMVDDVKEEPDDFLDETTKPNSTEFNDDEDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HI53</accession>
    <name>A0A922HI53_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HI53"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="135" mass="15220" checksum="FAE4B0BAA2C03F18" modified="2023-02-22" version="1">MNTKNSNNNDGCDYDQLVSSNNRKSFCEPNSDYDYPINTKKSIWNMKPTSIGHLNSNSNHLSPPLHSSSSFDDYSRNGMIQTKNLMQPPETITNILDMVIPKLPAKSITNSSTSSKDDLQKAKSFYYDIPEKYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HJU7</accession>
    <name>A0A922HJU7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter G family member 20-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_014728</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HJU7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03230">
        <property type="entry name" value="ABC_DR_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1710.10">
        <property type="entry name" value="abc type-2 transporter like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038:SF3">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 20 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="17"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="10">
        <location>
            <begin position="496"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9494004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="82599" checksum="18241D87F9317DBE" modified="2023-02-22" version="1" fragment="single">HHHRSSITIMDKRDIAIEVKNVSFKYHTANVLQDIHMTVPKRCIYALLGPSGSGKTTLLRLMLGRIKNEHGTIEIFGNNKPGHYNRVIGYMPQSQALSPELTIGETFDYFASLYQLSETKYSQISDNLKRIFCLPDDEQVVSTLSGGQQKALSLALVFLHSPKLVFLDEPTVGTDPVLGDQIWTFLRKNSDNGLTVIIVTHYIQEASLADRIGMMRGGRMIEEGMPKTLYNKYQETNLETIFIHICTQKPTENEIKDKVENTQRKLSSFLPYKRNSIANNTNTNNHLLVVPNYIRRKSSTIDENQLNVKLNTKSLLWLLFILVRRNIYQFFQSKFISVMVFSPTFCTLLMCIIFKVDMIRLNTAVFNQDVGRHYSQEFQNHVKNFSLYHINYIQFDSLDEAVDQVRKGHATAAIWFQSNFSSALIKRALAAVNADSYNHNDDADDDSAEYDNENDEEDPMTISNRTLMASTIKLFADNANAIIARPLLDLFTFGTWELYNQVFRDEGQVAIASPVVVKEVVYADNIIHADFLLPGYMIGFLYLALVTITSQLLIMERNDGFFDRAIVAGAKHSLMFFSHFIANLLFAFFQILLMFLIGFAWYKMNNFGSYLLMFFLVLLQSASAIMTGLLISATCEVNFSAFFIALSVTLSQLFTSGAFFPIVSFDPVIKFFLSITPIAMPVESLRNVMLRGWNLDRFHVLHGLLANVGTTIVFGLVALYFFKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKU0</accession>
    <name>A0A922HKU0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein lin-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LIN9</name>
        <name evidence="6" type="ORF">DERF_014038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKU0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033471">
        <property type="entry name" value="DIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010561">
        <property type="entry name" value="LIN-9/ALY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045831">
        <property type="entry name" value="LIN9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21689">
        <property type="entry name" value="LIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21689:SF2">
        <property type="entry name" value="PROTEIN LIN-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06584">
        <property type="entry name" value="DIRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19438">
        <property type="entry name" value="LIN9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01135">
        <property type="entry name" value="DIRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DIRP" evidence="5">
        <location>
            <begin position="109"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="532"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9493277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="590" mass="67836" checksum="FA290D07CEC24B6D" modified="2023-02-22" version="1">MSQSNRVGHPIRNRKKNRLIFNEDEETSFGSNRMPLYSISSSMANNMKSNNKQSISNNNNSTNKNQQQEESIVIYKGKFSKNIGNNLMNSLKTLLKLPKAYNWVILEWFYGSIDQVLFLDENEFSLCLKDSFPQLKTRYLTRIEWSQIRRLMGKPRRCSSSFFDEERTTLHTKHSKIRYLQQNKVADINIYKDLPEYLPQPLVVGNRVNALARQHEGLHFGTIEGINPSNGTYRVRFNRDELGSLTIPDYDISSSDIPQLAPLSSFQIKTRKTWNLSNRIVDSIATVEPHLLTSSSSSSSTTTTTTSIQQQQHQQQSEIIAKQRSKILEVDQCIGGFPIKFLTYMVKASKILTLKKRKLTELQAMNTKIERMTTLSMPISYTFKKQYALTILDLERTNKELCFHLKKIQSYSLQIALDGKLKSLRPDVLTQKYQIESKQLIEKLQGKFKVSEKMRDLIINLMCLLVHLRGFRDCEISSHEFESLLKALSTIRDMIHRDNHDTFQNNVEIHIRHIMTCVSHLGNVGAFAESTTSSSLSSTTTMSTSNLYNNANSNNNNNNNINNNSSSNSSQSNQHHHHHHQNDMIKTEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLP9</accession>
    <name>A0A922HLP9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLP9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7028" checksum="A6432D0F941BA825" modified="2023-02-22" version="1">MINAVITDRVELSAITGGIRTITGTSAHIFVFTAVPMDLALSRQPDNFQHLVPDISIRDYHQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLS2</accession>
    <name>A0A922HLS2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLS2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7321" checksum="F8086A732F45EA38" modified="2023-02-22" version="1">MPLANDNVQSMDSCFKDMDQDYFLDKDNGVQQQQKILKENYWNFAMNVNTSFLLAKCNNETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMT2</accession>
    <name>A0A922HMT2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleolar pre-ribosomal-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">URB1</name>
        <name evidence="2" type="ORF">DERF_013675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMT2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 C-terminal" evidence="1">
        <location>
            <begin position="260"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="591" mass="69779" checksum="4DDEE076BA630961" modified="2023-02-22" version="1">MAELIDWTDNEDIVRLATENSEILNEHLKKFLKNLFPKQNNNVPTNEEILKSLNQFHTLIEQISDRKECYEFLDYTLDLIAGHSVVRDIFLQSSCGAIRYKLIQLFYSLCVIRIDHCKVIENIVDFILSSYHATLSLEDQTLIQLLYVLESNGFNMQKYHPFIWGESGAQFYAAKHSQKLPFLRSPNIDEIFQNFNGRYFTNSISCFPIDVAIDDETVPILEGIEYSDRYDPRFILPMFYHFLSVQSIVKYHKFITYGCLAYTISALSSYCIRIRNIAYRILARFHHHLNCAKYPEDRQLWIGLIDFIRSGMIEENQRIECSHTVMFARIIEILLNPTCLLFPTIRNFLIHTQSKPMNYRSIPFSLYTACISNMDGTNPISYMLHQKFIINWMIHSLRTDCDVRMWHKRQTITDMLTYYNSPLCPIDNRPLIMRLLQTIAKLVEGIKILCQECAIFAWINHQLIIEPHYGSSSTSSLNKDALYRLLINIWHTAYMEYRRQNKQQQEKPDQYHHHIFYESFCFELIMMMSKIIYKVNDPERIDTFVNICHKSLKHLPSNCKRQQQQRQKLIKTIVCCNLPINLETLLAAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMV6</accession>
    <name>A0A922HMV6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Ganglioside GM2 activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GM2A</name>
        <name evidence="5" type="ORF">DERF_014674</name>
        <name evidence="4" type="ORF">HUG17_6544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7644182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMV6"/>
    <dbReference type="OrthoDB" id="6500577at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028996">
        <property type="entry name" value="GM2-AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357:SF0">
        <property type="entry name" value="GANGLIOSIDE GM2 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357">
        <property type="entry name" value="GM2 GANGLIOSIDE ACTIVATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324693" evidence="2">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="3">
        <location>
            <begin position="30"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7644182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9493950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="205" mass="23050" checksum="66E76F885D0627F9" modified="2023-02-22" version="1">MISKILFALSFIITIVHGHLLIESNNPNDFRWSDCGGQIIRFNKLDFEPKPLVLSETKELYLTGDISINEDLPLDAEMTIVVNKTLNYDNDPYNITLPCIDGTFGSCTLKVCDSFKTWYNDLFCPFFQNIGRPCSCPIQAGRVTLNHGRVTVPFEQFKGFLAQMASGDYNAKFIINNPGHFGPGDNLLACLMLHARLVEKPNQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN14</accession>
    <name>A0A922HN14_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ell-associated factor Eaf</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">EAF1</name>
        <name evidence="13" type="ORF">DERF_013741</name>
        <name evidence="12" type="ORF">HUG17_0927</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes transcriptional elongation by Su(Tpl)/ELL. Essential for development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN14"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027093">
        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF2">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="11">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="417"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="472"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7645389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9497781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="506" mass="54871" checksum="7055593A5EF6999A" modified="2023-02-22" version="1">MSALADFAHKFGSQPRELKIGQSFFTDDANTVFHTIRYDFVPASIDPNQESSMDFGENGKVTITMPNVEGSGTNESVYQGQRKPHQKECVLIINNETGDITLERLNQSMIVKKARLRQEDRNGKTSSSSLVLNSKQTTGMANNNFNHLNGNSSSSSSNITQVNSNKINNTDKKMMHKNSLLTNNGGQQQQQQNLAKKTSPSLSNGTTNTYNSTTTSSSIRSNELSANNNKMNNSTISPPSMPVFNTTNNNHTKSVNNKNSHHHHHQNNDINNQEWKIKMPDPPDIIKSKSNYSTNNNNSSSNNKKTMNNNNCLSELSSSDSSDSDDGDSSSDHFSDNDDDDGIINKKVNKLSSTKSSGLLSSSSSSNIGQQQRSTTSSSAVAAPSMPSFVAALSTPIFNDCSIDHDKKNITAASGSKALTLSEDSDSSSSDDDDGKNKKSFKKMSSMKRTTAAATTAAVVLSSNNDHSIVDNSKANNNNNSIVFNSMPKLSQLSQDLQLSESDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN92</accession>
    <name>A0A922HN92_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN92"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036758578" evidence="2">
        <location>
            <begin position="20"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="295" mass="34494" checksum="16FF605CC5622957" modified="2023-02-22" version="1">MKVKVLITIILVIISSTVCDSIFNHNSHNYQYPKPQQQQQRQRQLQQQQHRQSNQFYGSSSNGNHNNNNNNNNNNLVQASIIRKHRIVYVDSPSSSIDNSKSVTIQVPAQAIPLTLILRSSSSNLNVIPQHDGSNGGIYEETVSTDEPIRLIHTIRKPIYQEIYEYIKPYRYVKQQILPVQETISTIISRQPLNNNNNDDDQQQQQQQQQRENQNNQMLLYSSSSHHNHDDHHHQQQQQQQRTITMEPYEQQESKQQQQQQSTLWQIQMRNELGQQYWKAINNGLLINLYGIPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNN7</accession>
    <name>A0A922HNN7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNN7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="95" mass="10129" checksum="FD6C26EDB7C787EF" modified="2023-02-22" version="1">MVVNDVDVCLIFGGLPRRGSTRIKFPSGLTGLVTIVVIVVVLRSSLELLLLTTTARPTIPSDLAESINFLSPLSIIKGVIGASKSLAPDLEFTMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP12</accession>
    <name>A0A922HP12_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">CCR4-NOT transcription complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CNOT2</name>
        <name evidence="7" type="ORF">DERF_013205</name>
        <name evidence="6" type="ORF">HUG17_6157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP12"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="332"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="149"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7643795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9497200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="462" mass="49573" checksum="FBCC463B89FAA700" modified="2023-02-22" version="1">MIDYSSTVTAATSPSAATSISGINSSSSSNSQSSTTASSIFRQSSTSLTGQSPGSSGSISSSATNLLMHNAFGNIGSGHIGGGGISGPPTLDLNEFPSLTGQAVSINTFSQQSSAIGRPAYVGIMKDNVTNQSGSNEFNIQSEDFPALPGASPGGTATSAAAVAAAFNQFQQQQQQQQNLDGNNSGGQQQQQDHQHLQHHHHQENNRSVTTPPTLVGTTQQTAAAVAAMSASSLTSSLFSSLSSHQSTNSANNNNNGAKTSSSNSQIPAINVSKDGMVTNIPPGMLTDQYGIAGLMAMLHQANSNPNLFALTIGYDVTALNMNLGTKDRLYHTFPGPWNDKPLKPHEIDYSVPPEYLIFNSIRDKLAQIKLTSYCEDLLFYLFYCLSGEHMQAEVGAELYSREWRFHKDEGIWITRKQGSQPLEQSSNFERGSYIYFDLNTWSKNQKEMLIEYDRLDGPSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP19</accession>
    <name>A0A922HP19_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N6-adenosine-methyltransferase subunit mettl14, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">METTL14</name>
        <name evidence="4" type="ORF">DERF_012153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP19"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037816744" evidence="3">
        <location>
            <begin position="26"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9501297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="460" mass="53436" checksum="7EC3A9252F561E65" modified="2023-02-22" version="1">MVPLLKLGLTLVSLIIVELIAVVESNTTMVSFLAINYGTIIIPDEKCEQIVQKEIEILAIIVTKKKILILTSDYHVFDLSANFYDSTTNTVNLFQKSTLMSDKYPKLWLDSKFDSMKSTFKDVRFIIDHKNDIWLCFLTPFLAPNSGINYNVYNGEIVDGWHQQKHDAEIFISTDIDSYQYVVRTNEGIKFNMINTISKNSDNDDYYINKRFSTVCKYFDNADSKIYFKQFSPYENCENNGHFDVDWSIINGFVTDGFFHIVTTKGVLIFKEQIFHRQFTPFPVKQRSLQEFFLCSIPVPVYPTKSFFWLIAILIIILMLLFFIMFLIIMDGKSLKPPNKHRHHERISSSWKQKPSSSKRISKFSKESQQQQQDPPISSAFSSSCPSKNDSIQSFRMDSKNLKKIETISSRYLPTNQITSKQQQQQQSSFKIPSSFIIMYPKPKKNNNTVAYRKISKSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPU6</accession>
    <name>A0A922HPU6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein abhd12b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ABHD12B</name>
        <name evidence="4" type="ORF">DERF_013609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPU6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="165"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9497635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="393" mass="45620" checksum="5D20D8225A35E142" modified="2023-02-22" version="1">MDSHIRKRVSSSATMTTKIKNDDNMKKDASSPPKKTKSFHRQSINKTVCRQNDENKFIMMIRRNLCSIILSLIILILFIVFVIIPIIVRNSFTFQHLGVFLNIVNFHYFYDLSDTEQFGLRCARSFRIETNDEKISLGAWHIFPGDEHEECKRAAHDFNDDRIIFLYLHGNMASRAFYHRRELYNVLSEKLNAHVIAFDYRGFADSTNVMPSTFGLTNDTRNVYEWILKNNVTSNRIIIWGHSLGTAVATRFLNECPDEIYPFAAVIEAGFTSIVEASHHYPLIKLFSFLPYFEYCFVEPLVNNPELNFNSTAQLSAIRCPLLILHAEDDGIVSYDLGKKLYEQARHLQPKNVAQRTQFISYPAHFDYGHQDIYLDPDLYKKVDNFLKSVQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ20</accession>
    <name>A0A922HQ20_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ20"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="152" mass="16784" checksum="A747228A2558811E" modified="2023-02-22" version="1">MLIHSNSNDSEQHEDNQKINWRSSNDNLQIFAELPTISLSDSLDFCFSFEVPIGNSVISIVCSSNLATSPLMIYFIGSTFTTVPLKFLYHGFISKGSSLRSIRLMLSTISRGLCLGTLLLKMEVLSSTPLTKTIGMIGTKHLGSIFRLPSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSM6</accession>
    <name>A0A922HSM6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSM6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6670" checksum="4E27FD76F60B6205" modified="2023-02-22" version="1">MVIMCLQSIYSYPISYCRQQASRKSVTGDNSAQIARPPNQRLFRSDTARSASSSRRNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSX9</accession>
    <name>A0A922HSX9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase rad18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RAD18_2</name>
        <name evidence="14" type="ORF">DERF_011379</name>
        <name evidence="13" type="ORF">HUG17_10662</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CDC42SE/SPEC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000006">
        <property type="protein sequence ID" value="KAH7640182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSX9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000004">
        <property type="entry name" value="CDC42 small effector protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039056">
        <property type="entry name" value="SPEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13502:SF6">
        <property type="entry name" value="CDC42 SMALL EFFECTOR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="12">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7640182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9506656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="9278" checksum="61CBDBF4D6E9B702" modified="2023-02-22" version="1">MSELWIQCFTCGIVANNRPQTTRRRIDRSMIGNPTNFRHTAHVGGSGDMSNHIRTIQNQMASKGGYDYAMPVKVSIPVVDVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTD4</accession>
    <name>A0A922HTD4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ELOVL7_4</name>
        <name evidence="12" type="ORF">DERF_012386</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTD4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF69">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9501547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="310" mass="37693" checksum="84F84166D9F671C4" modified="2023-02-22" version="1">MTNQRLYHYTYYLWGYWLEHQDPRTEHFRLVSISPYVIALIMYIYYVLVTKIGPNLMKNRQPFQLRNIMFFYNIIMVIVNAYYFYEAISYCDYLRVFLNFDYPDDSDRSPATLRAINLGWWYWMSKFADWFDTFFYVLRKKHEHINFLHLYHHISVPVFGYLLLKINPMVPAAHLFIIMNTFVHCCMYSYYALAALGPKIQRYLWWKRYITVMQLAQFIIGMIYGFFVIQFQHGYPIIWMIIGLTQPPFFFYMFYGFYRRAYQPKSNIITTNGGKIMMVINNNNNTCMMNNNNGVDNRKQQQQQNPFKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTG7</accession>
    <name>A0A922HTG7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adaptin ear-binding coat-associated protein 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Duf1681 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NECAP1</name>
        <name evidence="8" type="ORF">DERF_011633</name>
        <name evidence="7" type="ORF">HUG17_10066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NECAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KAH9506926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTG7"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:protein transport"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Adaptin ear-binding coat-associated protein 1"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="NECAP_PHear"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <name>A0A922HTQ1_DERFA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010966</name>
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    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAH9506224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <source>
            <dbReference type="EMBL" id="KAH9506224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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    <sequence length="112" mass="13239" checksum="0B227AF69E8CB91F" modified="2023-02-22" version="1">MCSCVFDMLNHIESSIRYLYHLFKKTKPVLPRIIPSPSFWHQQSILSKLDLINGMQSSENNHVDIGFERMEKLIDTIFDQLSEEITSLRHEFQHLQRQWLGCHKEPLLTTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTV0</accession>
    <name>A0A922HTV0_DERFA</name>
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        <recommendedName>
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    <gene>
        <name evidence="3" type="ORF">DERF_011820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAH9507121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Mediator/Homeobox_domain"/>
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        <property type="entry name" value="RNF220_mid"/>
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        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNF220"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1231"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9507121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1371" mass="148622" checksum="8250F9DAC7A26C53" modified="2023-02-22" version="1">MSPLNLLSTQQQQQQQQTQLSASSINSNMDPHSHSHPHSHPHHHHNVMIGSNNIGTIRSPDNLSSSSTTSKSPPSPTLPTTNSLLAAAAAAAAAAAATASNKNGNDLITSTSPHNNHQQQQQQQSIMANNAAAASLLHAAIATGNVPAAMSSTLAQMFPGTFPLHVAAAAAAAFYGQQQQQQSGQQQQQSTGQSYLYSQQQQQQQQQQQQQQQLSSLLANAAARMTPNAAFTLGLQSSGKKLNELNESKLSPPTQQQQSPNNNNNNTLSAMYAAAAAAAAAAAATSSSGNNHRGGGQSNNVPINHHHHHHPLMPLTNMMAKQQQQQQQQQQGHLSPQIDNHHHHHQTTLRSSLGHHVHHNGGPTSSLSSSTTSTSTSSSSSSATSLLSPILFSPLGGTTTTATATAAATNESIIPFNNHKQRKSMIIDVVGSEVASTTAESPYTGNCHRIATRTPSSPPMGQSGPTAANSSSSSIAATITGNQFSNMNNNGGQQSSSLSSSSLIGGQMTTNNGNNNGNGNNNVLYCPICSISLDGIDINQHFFEEMHKIDSMRKLPDWSNDQPSSSSSSSSMITNHHHQSNHHNDDCRATTNESITMTAAAATTTTTNKRRQQQQQQHHQSESLLSKQQKNYISSSFDHHGKFSLPPPPPPSSTTQSTTSSSYQKKLQLPQSRWETFQRIRQNRHTRLAAFMRLTRRKYEAAYEMQLQQQQQQQQQSSLYPNHHLPIQPSSHPNHNNHHHHHSPSSQRSPNIIGTSSQASHPLQPPSTNHHVNHSSAFIGSETLFGHKSLESSSKSLSSNNNNHGSIINHESLPAAVAAAAAAPLPPPTLPIIPHPSLHQTTPSSILNNRNMLNSPEGPSPSSSTTTTQTRSSPVTGSSNLSTTTTTAAAAAAAAAAAAYQAHSLFAHSNQSFLHSSLPFYPYHPHSHPHPHHHHHHPMGAAFTSGAYPVGSGTAAAFPNTESFFHSNSTVNNNNSPGLSSSSSSSGLPHTTTVQQQQQTQSSYSAVKTNQNGQPKIWRSIDTDKLEIISDSEQEQNRSIDNRKDDNNDDMEKSRPNSHSNDTECQQQQQQKQSTINSLDNVSINHSPANSTHSSQDSGNKLKIIDDDDDHKQQQSIMVKNEISNSNSNDNDVLNLMKKSMKTTTTTTTNTSDIDSDHVTNVSSISDDDDDNDIVDHHDDNGNAKTNDNDDDNNESMMIIRMKKSEKIDNEVDDNDDDDDVDVVNGDDIHHHHHPHQHSKHLNFNHNRNHQNHNHHHHHLHRRFIDNHQQKKSFKRHFVDVYHHEEQQMMNRHKRLATNTTTTTTVNATITTTTNAAVAVSGTQSLNNNKQRLHAESSSSSSSSPSSSSSSSSSPLSPNIIMNDDHHLDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU46</accession>
    <name>A0A922HU46_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU46"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6703" checksum="F1AC90061E16B335" modified="2023-02-22" version="1">MCYNNLKIEIANNNNNNKQFILCDDSNSKPVKHGIFRFSNLFDSDQNKLKNGSISIPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUE0</accession>
    <name>A0A922HUE0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUE0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="225" mass="25346" checksum="3629BAD3E4E8CF4F" modified="2023-02-22" version="1">MRQEFIRTYCFPKRIDHDDYRKMLENLSKSEDSIKRNGFGIPNKCYICSKLNQIHGKSVLFQTKRDFFKHVRLYHSDYSESMKMKKLPKPTNKVIKDVVPSSFSTAITKSVIPIDDPSPSSSSDFFNSNSISTYSGQYARIQKSPPCSSLPTESNSHSSLSSHQLPKFNPILTSFSSKILTTKSSTPKVSVSKAKTSSKQSNMKIPIGGKGIILFKRSTQVQQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUI3</accession>
    <name>A0A922HUI3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUI3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="101" mass="11408" checksum="7C28DAAE0A214A7A" modified="2023-02-22" version="1">MIAAAQQSGCVNDFWLASITTTDPISKIRRGPFSTGLYGGVAIFCDLQIGGYQLTILLFIYYLLNNYHRFITISLTPIQQIINTVFNMNFIVYTQTQDTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV59</accession>
    <name>A0A922HV59_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV59"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="154" mass="18015" checksum="DBB95E4F1C514A55" modified="2023-02-22" version="1">MKLNDYLFVMVSVCHSGHRISFLNNRNFIETYRKYGFVEIILDDYDHNNNNNNNGDLVKSHPIKSVPVTQSFGFSFHQIVPYDQLNLYYRNKNENCFCKVHEQMVIVMWNEQPDLIIIDNLLIPSCIEFGHIPYGSILGVSIHCICFNLINCHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVV7</accession>
    <name>A0A922HVV7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVV7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7416" checksum="08E73E062B267445" modified="2023-02-22" version="1">MVVPPSSSNSDSIIGSIPAQIAAVNHNNITTTNDHTDAFHHCTSLMAQGLVEQRGWMFYYVKPNSSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW84</accession>
    <name>A0A922HW84_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Down syndrome cell adhesion molecule-like protein dscam2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009119</name>
        <name evidence="1" type="ORF">HUG17_7607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW84"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7637401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="232" mass="26086" checksum="6844966C7B2C908E" modified="2023-02-22" version="1">MAIIINHQSFDYLIILSFAFILFDDFCCLKISSIKSSPQSINANVQQQKRGPEFLIEPPGIITFINDTGTVITCSARGQPSPKIYWIYATIATENGIGGGSMMNHLIPVDGLQQIRHDSLASQLIYLPFKSNQYRQDVHSIRIRCIATNQFGSIQSHDIQIRASVRQPYDIQVYDDFVIKENTGILRCHIPSFIREHVRVTNWLRHRDDNGVVGGGNTAGDQIIISDLIKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX85</accession>
    <name>A0A922HX85_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Venom dipeptidyl peptidase 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DERF_007101</name>
        <name evidence="17" type="ORF">HUG17_1567</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family. DPPIV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX85"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="16">
        <location>
            <begin position="139"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="15">
        <location>
            <begin position="627"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7646029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9516354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="846" mass="97941" checksum="6E2005BC9F685738" modified="2023-02-22" version="1">MTEFDDDNDNDTVIPDDFREMHELSTVDVKTSNWKGTLISILVIILLSSAIILAIYIINPDIQYKLINETREKLKLDELLHGNYTVQPTFNGTWISDTEITFISSAGDFVLYDVRADKTDTIIYARIMKQHEVDRAILSPNRQYVLFISHIKNIFRHSTVAHYKAYHLSNDTIINIRPHEANIDASLQAAEWGRKNAQLIFVYANNIYYMADPSDSQTYRISHDDDRYIYNGIPDWIYEEEILASGTAFWWSNDGSRLAYIRFNDSQVEIQEYPWYGDQVDVESQYLGPIKIKYPKPGSTNPTITLHMVDLENSSFDPYEVLPPIELTKQSNDYYLTSAAWADRDCLIAVWMTREQNYASYSWCSPSSSEMDHKWKCKESFHKQLNNGWIEISSIHVDQYGKNYYILHGDESSEQFVQIIKVNIKTGEKNFITSGKRDVTKILKIIPIYNNDGSESNKIYYLATRTNKPGERHVYNVLDKTKWMFNRNNNDGDVDDTKCITCDQIELNQCLYNRITFSKNGTYYIRECLGPNIPYSTLHLLNDDGGNNNYTREWEMNEKLKMTLSRKLLPTIVTEIINKTDYVLIVQMFMPPSFKPDSVVKYPLLIQVYGGPGSQYVNENFKMNFGKYLAGSREIIYAYVDGRGSGFQGETMKHHLFHRLGTVEMDDQIIAARYLRDKYNFINPDAIGIWGWSYGGYATAKILIKDHHVDTAVFACGISVAPVTSWLLYDSAYTERYMGLPTNETMKSYQTSAVMHDIDLMRNKKFLLIHGTADDNVHIQNSMVLIKELNKANIMFNTQIYPDENHGLPGVSVHLYETMANFWNECFKSDSYVEEIGLRRRRVSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXI5</accession>
    <name>A0A922HXI5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXI5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9515868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="123" mass="14737" checksum="C0D3DF06191B47B2" modified="2023-02-22" version="1" fragment="single">MIIIKKNYDDHDEQHSPYWFMKHITIVFIIILIVIIKKTTNTTITEQRRNLNLTIESFNIWHGKNSRTIRDSLSSRGLNSYQLKQGKWEFYKIGISLFRPQISKLIFYFLDSLASILIHHHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYL6</accession>
    <name>A0A922HYL6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">AMSH-like protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">STAMBPL1</name>
        <name evidence="12" type="ORF">DERF_007646</name>
        <name evidence="11" type="ORF">HUG17_2010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYL6"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="241"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7646472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9516936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="411" mass="47993" checksum="184528A663212A50" modified="2023-02-22" version="1">MSIELNIDDLRPPAIVKNPEERMKFLVEKSKNFVVEHSIPIRLYISSGRQLLQMANTYLDEMNMEQAFVLYMRYITLFFENLPSHPQYDEINEEDKRSIRSKLKPLFGIAEVIKIRIQNKYKEEYENYLTQKKIYDEKLTKAQKALIEQRQKDQQNLEDKKRQDYVTDLQSQIDKKKRELADKKNENFEDKNEVISDDEDSSSISTDQPIKTQSHHKPVIDRSTKPSMSLLDDVDLDTLRSMIVPFQVLTKKFVKIAQQNTDRNIETCGILCGQLKNDNFTITHILIPKQTGTSDSCTSINEEELLIEQERHNLITMGWIHTHPTQRSFLSSIDLHTHALYQKMLPEAIAIVVAPTTSEIQMYSLTEHGLEFILKCREKGFHPHTNEQSLYHSANHTIINDKLCVDIIDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ25</accession>
    <name>A0A922HZ25_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PAK7</name>
        <name evidence="15" type="ORF">DERF_006697</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ25"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06648">
        <property type="entry name" value="STKc_PAK_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000073">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000002">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF8">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="524"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="409"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9515925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="791" mass="89427" checksum="E84946509B9D92A1" modified="2023-02-22" version="1">MFGKKKKKPLISAPTNFEHRVHTGFDRKEGKFVGLPPQWLSLIQGAGGGNSNRPKPIIDPSNITPTEIMDIKSHTIVRGQNSSVNVATAFIAANNKDINNPQISSRSLVSRSNSLRRIESPQPLKQKFNQFQQNLMEHNENVINNDQLPNNQPIRPFNLNHNHNNHPSQQQQSLLNSMNMESMPTTTTTYPPSTIMNPLLSTANNFIMANRIYPARNPTPVIQYQIPPQPSNGNFHNNNNNNINHHHMNTQQQQQQSMTARNVYNSNKIRYGVLPQIQQAQFISHNNNAKITNELPNNFHNQQLNIHHHQQQQQPSSNQLQQTIIMPNSAMQQFNNNSSVLKSSSTMFQQQENNPDLISTTNSNNRITNATNIHSNTHHSNNYINQMNLNQNLSNMTIHTKPMNSINHLKTNGTSQHHTQISPASSMNHNNGGGGQETTTTGIQQQHKNPNHQIVSNAAKSMVVNNVQHDNVSNAAMNQNPTTTTTNSSTVTSATVQQQQRVTHEQFRAALQMVVNPGDPREYLEHFVKIGEGSTGIVCIAYDKSQQRQVAVKKMDLRKQQRRELLFNEVVIMRDHHHPNIVEMYNSFLVDDELWVVMEFLQGGALTDIVTHARMDEEQIATVCKQCLKALSYLHSQGVIHRDIKSDSILLASDGRVKLSDFGFCAQVSNELPKRKSLVGTPYWMAPEVISRLPYGPEVDIWSLGIMVIEMIDGEPPFFNEPPLQAMRRIRDMPPPKLKNLQKVSANLLSFLEKMLIRDPNKRATATELLQHPFLRLAGQPKLLVPLMRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ34</accession>
    <name>A0A922HZ34_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein CL16A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CLEC16A</name>
        <name evidence="6" type="ORF">DERF_010333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLEC16A/gop-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ34"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045820">
        <property type="entry name" value="CLEC16A/TT9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19439">
        <property type="entry name" value="CLEC16A_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="4">
        <location>
            <begin position="57"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="5">
        <location>
            <begin position="276"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="5">
        <location>
            <begin position="723"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="838"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1014"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1091"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1232"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1015"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1094"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1233"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9511909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1275" mass="144307" checksum="A9753B08D057FAC1" modified="2023-02-22" version="1">MLRPTKWFGWSRSSSESSLVRSNGNPHSLEQLKLLYRLLEKNQTVSESNRTLLVETLRQIAEILIWGDQNDSSVFDFFLEKNMLYFFLNIMKQKCGGYVCTQLLQTLNILFENIKNETSLYYLLSNNHVNSIIIHKFDFSDEEVMAYYISFLKTLSLKLNTHTIHFFFNEHTADFPLYTEAIKFFNHSEKMVRIAVRTLTLNVFRVQEKAMLRFIRDCTAAPYFSNLSWFIGNHILDLNSSLATYIESRNQSSSSSSSNIQGSLPHSNSSSNLINRLEDLVAEHLDHLHYLNDILLLDIDDLNNVLSDNLLYRLIIPLYMHSFLRIDSKFKSETSNSKEINVILSPSIAIFLLTQVFLIISYGALLKTLLLALISNKQDIETIAQKCEFTQPITSLEAAIEQAIQTTSNQNSSDSSEMLDSSPSHSINNNDNNEQLAEETVNNFDPNHSTSDENKSKIESCPAINWQDCSFLITLLASLNAKIIPNSESSMDNNNRNSNSSSSSSKNSERNNLSKSCHSSQIIRFIPDWTSSDDRIVLFSLSLISSIVSNKAIDSETYENIFLSSLNDDTSLPPTNSFHHTLINSLLLIMRQCSSSNSSIRLVTFELAVHLFRKLACCPLSSNVVNPPEESQATSRPHGHVILSDHQIAVLEQAREDACHILRHYYCSIDESIFLNLFEKEARMFHSHSCSTRTSISSSTSASPSKHSASDRSNQIWSYDSYLTLEQLFMDATLLLPPNEINKDDSNFHLRLPGIDCEKARYIIQVFFVLRLLSFDVRKSMGDTSTDDKAQDFSILLDDTITSPSVYLDQFIDLENCDLNRCSVTFYQLVNNQHRQYSGDARDRYSQSAPASRSESPSLMQNSNTSGRRMQRFMTIMNDLIILIEPDDKRYGWGVIRFIARLQDIEKIVMHSKELGHLQTSPPLPEKDNNKSLYIYFDSYRLSSSIALDNKMTITRIGYRNRQQSIVARFQFNDTVRSLVARNNLCKAHKKVLDRKIIAVANLIDVPTSGQTTVSQSIIRTGSSSKSSLDSNKKATNQNHHNHPILTRTYAVPGVAVPSKFPVGQSSDSSSNDNNTNKLDMLNKKRYAYSPAVSNNKTNKSISSNRQQQTSAKISIENERRLKKKLKYPANHLDNDHDQEQYGIPLNDLSPKTLRKNTSSTITAVSAAASVTLAAEWQENSNNSHLFNDTHIEEGINPLDNNNHDVVDAISLDNLNVTRMINNDINETIITANNNNNNNNNKNNRSSPPSSSSSSSSSLSSLRRQQNRTSETFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZW3</accession>
    <name>A0A922HZW3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparaginase</fullName>
            <ecNumber evidence="2">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_007192</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZW3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006033">
        <property type="entry name" value="AsnA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00519">
        <property type="entry name" value="asnASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="7" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="9" id="KW-1053">Target membrane</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="14">
        <location>
            <begin position="82"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="15">
        <location>
            <begin position="314"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="505"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="538"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9516457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="668" mass="74820" checksum="B24DD8B6F6D98689" modified="2023-02-22" version="1">MTDKLFSEDSCDSDAELLNNLPLNGGLTNGKTKNRQRRLSLNLAQTIPQQKLIDPSFEPKVLRKNKSIARIESYGTLAEESKVLVIYTGGTIGMVKNGSGVYEPRPGAFTQVLKKYPQLHDSEYFEKSWLLPDSEHLLVLPDTGEKKRVIYTIFEYDPLLDSSNMTIDDWVLIAQNIKKEYHRFNGFVILHGTDTMAYTASALSFMLENLGKTVVITGSQIPLFEARSDAKENLLNSLIIAGNYSIPEVAILFNNKLFRGNRTSKISASKLDAFNSPNMSPLVNIGIKIDVDWNNVYRPSTIAKVHVHSKLNRNVTLLRLFPSITVETSFLREPIEGVVLQTYGAGNAPSNRKDILNEFREATKRGLIIVNITQCPNGKVDPSYETGNALIEAGVIPGSDMTPEACLAKLSYILSKDEWSLEKKREMVRTNLRGEMTVIRERRVEDVSLVQAIASTLKVSTSDEIEKLRSALYPAIVCAITARGDVESLIQLKKNGIDLCACDYDMRTPLHIAVSHGHKDVVKYLLFEGVNVHAKDKNNETPLHLAIKNQQHEIIKMLIEAGASLDLPKNRIGDLITNAAANGKLQLLRSLRLAGATLEEKDTFGRQCIHAATERNQLEIIDYLVNVINVNRHKTDLYGRTAKDIAQFFGYKHILHILETRNFQKNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I002</accession>
    <name>A0A922I002_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_008462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I002"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="347"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9517839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="508" mass="58169" checksum="BBE21F7C0627CAD5" modified="2023-02-22" version="1">MSESSSSSKKLNEARCPICNFRLRSCANVDRKLIKSQENIDKVLRLMNKRVEIGDILCAKCNKKLSRQNHSSMLMDNSEHFTSTLSIDDSISTIIDDQSQSIMVDPTLEYTQIVKDVIEMPFSRPIISHSRCFICPSTSNLKDIPIEARLQVFLKRRILVPKRNRCCKQHLMNGWLNEDEINNIKIESDKCEIELSDIAKFMDLLASNSLNIKDKINKRLMPQCQLYALTAHSWEDIDHLQSLMTYMKNTNKRSVIQAIVTFLCKLRTGNVNKVIAVFSGMDSEKMVGSNIDSVIKSFEVDILPYRFGYQSITRDFLINERTSPVVKNLLDCQNNLIIICDGTYNLYQKNSYSGNKKTTLCKLFTICTTDGFIIDVPGPYNVNENNATILNEILNQNNGLSVLLQPGDYFVLDNGFRDVVPILKKRGFNVMIPNLEEKNIEPTNDSRLATKIHWVVKAVHAEIGQKYKLLHNQFENKSLPRIAAYCRIAFFLHNEFGQKFNFDSGNME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0M1</accession>
    <name>A0A922I0M1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor IIA subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GTF2A1_1</name>
        <name evidence="6" type="ORF">DERF_008779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0M1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.100:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9518184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="829" mass="88800" checksum="0122132B7BFB4803" modified="2023-02-22" version="1">MAAASVYINNKIVIRILQPRIKVHHKKSSYIFINKNIMQQQKDNCNRWQSPRQQIPLNITGSTPYQTTGNRGMDASNSIILVMVIYHHHHIRFLIHRIISRPPRPPHSRDIVPKFYKSVIDDVIASIREVFLDDGIDEQVIQEMKQTWERKVLESPAVEHALQQAQAQAASPSTTTSATATTTNTATTTTNSSSKAEKSSKNSHQKKDREQQQQQSNTGQGQTTSVITSNPNHVQKNGGNSNASNTKTSNNISSKVIKKEISDETVATTAMAATSKKQTITASPNTVMVANQLQSQQTVVTTVATPTLVTTSGHHPQQQQQQAMFRASAIVQNTHSLQQQQPQSQHGFIGMATSAPPNGGAHAGTPTLLQVSSSTSPTNSSSLTQKTNKRQTGGGGGGKHIQHTLASGMIVGSVDGGGGGSSYSNIGVGTNGLGNSDVGVRGSFISPLSTTTAANTSSLQGQSTFKNVNSLAISSSDNNLNNNRHHNSDTINSSNNHKRIRMDNRPSNKQRQASNNSQKSIHTSQQQNNLNDLADAAIIARMNSQDSSHVGLGHPLSIGSGQHGYPVSQSIPFNLSTGTSTNLSLIRHDRAAATEANSNNRYREQMLQQYYIDSLFNQSSTSPYSSAYAATSSNNSTSNSGPFVHRNAGTSHYNNIVGGGGGGSNNNIGIGGFSHMSNSSHKEVKFPPGVIPGKFIMLPNNMNHPGTFVINPELLNSINLQHGSSIIHAAPGAQPVFQHQGIAPGTIPYAAIRATGVQPNVGITSSPLQQLVRGQVLTTLPTTLTSVLTPTVLTSGAQQQQQQQHSIDGIMNLQGKDYVFSRALGDAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I207</accession>
    <name>A0A922I207_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I207"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="36" mass="4337" checksum="8E61584CE516794D" modified="2023-02-22" version="1">MKNDEKLSNHQPSPQQQQQQQQQPKKKTLYVGKWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I262</accession>
    <name>A0A922I262_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_008687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508:SF1">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47508">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHR" evidence="4">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="3">
        <location>
            <begin position="1172"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1475"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="774"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="1075"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="1485"/>
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    </feature>
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            <begin position="1503"/>
            <end position="1516"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="1523"/>
            <end position="1539"/>
        </location>
    </feature>
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            <begin position="1540"/>
            <end position="1551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50104"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAH9518089.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2F6</accession>
    <name>A0A922I2F6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008073</name>
        <name evidence="2" type="ORF">HUG17_2335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2F6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276932" evidence="1">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7646797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="97" mass="11016" checksum="081863789ABC9C45" modified="2023-02-22" version="1">MSQRKISTTSFLCLIIIMAMIIKPSQGYCCHRVRIYNCSGTDELQTLCPDCTEPTPWCGVTECNLIGCNCFGCREQKQYTRIDNLAITDNDDPINHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2Y5</accession>
    <name>A0A922I2Y5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2Y5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="78" mass="9188" checksum="942F2DD7459E1646" modified="2023-02-22" version="1">MSWEWECGHKIKVWLANLSRIDQDLSTDCTTSLRDQRTEDRQMAEIDYCPFMELTINRLVKLVKTNQGQKKLAMAEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4N1</accession>
    <name>A0A922I4N1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Wd repeat-containing 18-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">APAF1</name>
        <name evidence="7" type="ORF">DERF_004283</name>
        <name evidence="6" type="ORF">HUG17_0429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041452">
        <property type="entry name" value="APAF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845:SF5">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17908">
        <property type="entry name" value="APAF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="ATPase" evidence="4">
        <location>
            <begin position="209"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="APAF-1 helical" evidence="5">
        <location>
            <begin position="572"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="767"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1467"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1474"/>
            <end position="1483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7644891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9520581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1536" mass="178779" checksum="F04381EAC956FF5C" modified="2023-02-22" version="1">MPDHPPVDNDEDDDLDPSTLCPIENGKNGNHHNQQNGIYHEQQNQNSSTSSLPLKTENLFDSIDLILIEKFWNEQRKQFIKQIFPDFFIPTLVKFDIFSDYDQIDYSIIRASRDLDNCSDRLSGYEELNEWIFDKLLFKIRCNSRVLSIIIEALRFDDWYISLADEWQTQLKRKSEQVNNQKSPESIDNKNKVKNLLINFPEPISYKIDRKTEQRKIESHLKEMFENGKGWLVIYGRKGSGKTVLAESSICRSDHSHFTDGIYWINVGNLTITKNKNIDSEEILRQELYTRLELLFQSIGYFHEKNQTKPEKLENIELELNLHFRKHPKSLLVLDDVQSHEIFKYFRFDIPIVITTFDKGIIPKELPNVRFISTQDEHGNVLSHSECNELLIKCINNDKFKFQYLLDSSNHLTKLFDAFDGLPYCIPLIANYMIPFIHDYSYKDSQKMNELEKHWQELHKTLTEEDSFLAGSFYLLDLTIEAMKIEKLVDCFYDFGIFPEPVSFDALKIIWGTNKFITANYLEQLFQKSLIKKHTINQARTDITNQLFTVHDLTASYLMKKLKEKKQLEIRHGKLIDSYFKDCRQSSTNLDYDFSRLPEDKYIYRCLSYHIYSSGRYDLFEKIFLDLNFLQKKIRSVGQSHVLSDFHNYGHFISERKKLCDFQKFIASNTDICDPKVDLLQVALCQSNDSIVYNEARRMIHSNSNFYFDWCNKENFVLENQHKKMNFKCFPDTNNAALSPDCHSIVTVNDCQLNLWNSKTGENICSEKNHNQTINHCTFSPDGHYILTTSDDGTAIVWRMTGSLSNRLSHNQNLVSDNNNHFEGRRRHNSGRDIHLISYKTIEPNISKYKSDSIGDHSTSIALKCGHISANNRYLLLGTSTGFVYIFSIDGRQLYSSPNPDDLLSGVSCCSFSSDNHYFLFLIEKMVYVYSMNIGLNNSDYSIKPSLVTKLEHNQVAHNAVFNLRHKSKKISVFTSSDKNIFQWDIKLPMFSKFRKKKKTERTEKDVSFLYALPGKASGYISICAVSSDGKRIAGFETTRNEIYLWNRKISQTIHCFHTLSSIVTLCFSMKEQCLFALNSRNEITLWDVEQGIPITSVVELKDDFAAIFNHDESILSVLTIDKKGFLRLFHDKISEEDKEFKEKLKQMLHSVENDNDNNDFHLPQPATNILCCDISKRNRSIFGTNCGRIFYYDHHQGQLLSSRHDSEEILECRFLPETNNDNTIRLVAMSKKSSNLYRIDNEIGQMINYYTYNNQKILSENYSFESIHFISSKLMIFLTTDSDFIIFDLDSLEELYCLKFRSKITDIDSCLLDGDYLIAITFAEHRLLLLHLTDSSLDPRSSVTLKNEIPRCCRICTRFIVYGSDNGNIYLFDSQQFQPLEESPLDMNIDPKWKVQHSQDSWIKHLAITPDQQFIISAADSIKLWLSIDGTLLQTFITHGEVSRLFVHHANNSNMTNSGFFSPQSHNGYNFDDHDDDDDDNSNEFQLSDNDNDICRETFTPLYKESSLDITIVAITDTKSLYILQNYRLNNCDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4N8</accession>
    <name>A0A922I4N8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4N8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037954610" evidence="1">
        <location>
            <begin position="25"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="263" mass="30321" checksum="784016AA0EEB4B8E" modified="2023-02-22" version="1">MKYLPIILLSILNWFVANIWIVAAVNTQSSSLSSSSNSSSSSSLSSKCSSSVLEAYDHDMAKLMTIGQRIWPESYQDSKKFCIESRRLHDKINQYKNRCSIGTAKQFTSVIIYSIQRAHKTYCPKQANKKVINFFKAQSCTNRVMNQTTKCLNHYIDQLQAIIRAPIVKQIPHVCCQYFEMLKCFDKEYEKIPNCSESAEIFNNFVRQIFDDIVNLSCQDYNESTDRCEHLGQPPSLLLTKKKHFKSFILPLIDIWNQVDGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5F6</accession>
    <name>A0A922I5F6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 127 transmembrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_006429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5F6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033331">
        <property type="entry name" value="TMEM127"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046795">
        <property type="entry name" value="TMEM127_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28358">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28358:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20517">
        <property type="entry name" value="TMEM127"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 127 transmembrane region" evidence="3">
        <location>
            <begin position="310"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 127 transmembrane region" evidence="3">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9522877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="630" mass="70795" checksum="2A25EE4CD35C3DC0" modified="2023-02-22" version="1">MPEIRPEFTRFYHDLATRFHSGINNIRSFGQQITTRFHNNDSGGSAIDDNSIENNDNNNNNNNDGSSTNQPPSNSMNPFLDSSTNNNDPLNPSNVTSCSTNRSSNTNRSNRRSSSRHHHHHHHRHHSQTSSCRDREYHRQAYHPYLFSSNNHHHHLNSSPNNVSIIHRNGLITLRSLDDYHYKDRNVLAAILSIIVIAILATALVQPKWFSIYNDLCVPTTTPQQQQQQQQQRYFTKSDNSVDKVNTINNNPLASSSTIFNLQLSPKHHYTQYRPQYYHHNNGPFHSSYSTSYQLTPVTIYGLTPDFKTCANAQILALKRTIIGLCFLAIMCTLVQFFMDTMGTSSHHNRGAGAGKWWLNSMRQYAVGNILCVIFCVLIIGLCYFISLLYERVQLQQLFETKTPISPQQQQPNAVWIKSRMISRATLFAATTTTANGGGGGGGGGSIVQPLDYLTIHQIEVKFELSYYLITLAGFLSILASAANLFRRPRQIFIERIGGFNDGCSYNGRYHHHHHNRSLMARRLRSTSNGNHYHNNGDENSLLNSDVLLNNSLESSSSNTTPTSSSSPYDLFTNWTLYCTNSNNNNNHSTSTNGHHSSSIIMPPSTLPPPPSSIIPHSSASCPPPPPYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5G7</accession>
    <name>A0A922I5G7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_006108</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat fritz family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5G7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097541">
        <property type="term" value="C:axonemal basal plate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024511">
        <property type="entry name" value="Frtz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13667">
        <property type="entry name" value="HOMOLOC-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13667:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING AND PLANAR CELL POLARITY EFFECTOR PROTEIN FRITZ HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11768">
        <property type="entry name" value="Frtz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9522544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="629" mass="72872" checksum="E83529ECFADE0660" modified="2023-02-22" version="1">MYNESSSFELSPLSSRCLLNGYQPNNDRLKPYQIQKIRRRLKLLEHYLNNYSLCQIKWLERRTNGFRGIVFAFNHGLISSICFDSDYQSIIAIGHDQIVPHKLSSKRISSIEITGNAVLIAFVEPLIAMVEFDNLNESRCKLKFKNNYRLKHLEQLGGHNNGRGLAKRNITICESGHLTLLWSNRMPHRPIIKSLPITSTAKQQQQQMEKNLALLALDDFRLIEFDHSINGEILQADFVANDRDKFGVLHKQKTSVYNLTYSLFELIDSNSEHKGDNAVTIKLLFEIGIPLEKLCFGAEFTRLQDKILLLCDDESVMLFNIEQNVLYALHSSKPICHMATYPLDSIFVTCDPNGSISFYDIAFQNITHRTSISNECHPNSNMSVKRLQFLSSNILVVLMVENRRQDSFDTIVHPQQPLSSILRSKDPINSNRHHHMSTTCCCCMKLYILPYRLSFKHLINEYLFRKQYEESLNVLRTINWNCSHEQAYHCLHLIFQHLITAELSSVSSADTREMIVKYIESTLATFLLPMTPIDYKIFEQILPDIRQLAIRFFYHLVRNGSLEKAYQLGVELKSTRLFLLLAQLFRMNGQPELSAKSYEQAHKLLVYDATQMVNAETDCRKYRIKRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5Z8</accession>
    <name>A0A922I5Z8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5Z8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="81" mass="9585" checksum="96876BC4C9A21A52" modified="2023-02-22" version="1">MKKNHNCKLSSLSMCMPLPMYLVKIKPNLQNDTHHTTITTTVLVFLDIIIPSYSLLKHCFLQEKTDKDNKYEREIIHIYHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I638</accession>
    <name>A0A922I638_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RISC-loading complex subunit tarbp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TARBP2_1</name>
        <name evidence="9" type="ORF">DERF_005011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I638"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070920">
        <property type="term" value="P:regulation of regulatory ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051247">
        <property type="entry name" value="RLC_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46205:SF3">
        <property type="entry name" value="LOQUACIOUS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DRBM" evidence="6">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="6">
        <location>
            <begin position="110"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="470"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="636"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9521346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="769" mass="86773" checksum="8E102AF673AE9884" modified="2023-02-22" version="1">METPAAILNQLVIDNITDAEYTLLPCKGKLFQYRCEVKGHIEYGLGHSKKKAKQAAAKKMVIYILNDSKFTIAGNRDQIQSKLDQYDEFGASNELNEKKEATQIQQPSSNTISDLQILCSRKRWESPSYNEVETKGMPHNRVFVIECFIKEKNLFTNGSGKSKQKAKHNAASKMMAILKKRKNFDKSDEILDHHSNNDFLNNEEKDRLKAYNTFNFFAKITSDAEKMKKMKELIPNGNDFIQHFFAADKTVDSNKIEMLAANIAQIFDCKLVISCLPDKSSVGQYQYLAEFFATDESADTLPLITVWGADNDLIMARTKSVRYLILQIVFYLSINENFICHPDSSNNCYKMGLKINNNENRTTASPCAEKYARKRGMFCVRVQQHHHAQKNMRESVVCFANLSSSSSSTASGNSTDIMVSKHLSSRLPPPRRKEKTMDELIDKIKATEAASPPRAKPGRKSKSAAEEDTKEKKRLSLERNRAAAMRCRLKKKKENDELKNRVEKYEQQNQQLKLYFQRGQGQSLDELANKIIKSVNELYADMPEQSRERLARDRFYAALDERLVVALVNSSNLKTIEEIKALAKAIEINLPSKAKQSSSNPSFSGGNGNKQKRCHNCNRMGHIAADCRLKKNAAKNNSSELSSNKTSSSSSSSKTASNQTISKEIASICDESNRIIPRQFLRSKINRKTVYCLIDSGSKVSVFPSSWPIEKFGQSVLHTTNGSSMLVKGESIVKMNIDSCVIEHTVLIGNVTKPIAISSRKFQLRLLMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6A4</accession>
    <name>A0A922I6A4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_008702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6A4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9518105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="403" mass="44894" checksum="CCD45B120C082A5B" modified="2023-02-22" version="1">MKRCTANEFECIRDSTCIDLSSVGDGIIDCIDSSDECPDPIQQFRCRCGIPICIDRKHYMDGQINCDDGSDEGLEVTICQSFIQNELLPNGMLTRPQQQQPQQRPYDMNVPFMTVIGEDNADDDGEIDDHNTTTAAAAEAATNGNKYMADVDVDDPILLIPENIEELFSSEFFDSLSTTSSPYIDEITMNSTTTNNGDDIVSESNDDDDDDKDKNFSSSSSLSLMSSSSSSPSLLIDEQIITPNSSTIIMIDNTIETSTTKQSTMATTTSTSTSHQDVVELTGTFLPYELLTAPTKYPYYHRSMITPPILLEKLTETNSIVEITGTFIPQMMTQSYDSETGQHRQPMTTTITANNNTMMNESVNKERWKSTMTKIDANHAVETEKMARIKNQTSNKSNIYHWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6T0</accession>
    <name>A0A922I6T0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="13">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-specific succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="13">A-SCS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Succinyl-CoA synthetase beta-A chain</fullName>
            <shortName evidence="13">SCS-betaA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SUCLA2</name>
        <name evidence="18" type="ORF">DERF_005383</name>
        <name evidence="17" type="ORF">HUG17_3584</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="11">GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + succinate + CoA = succinyl-CoA + GDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22120"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.2.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="13"/>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6T0"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03220">
        <property type="entry name" value="Succ_CoA_betaA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034723">
        <property type="entry name" value="Succ_CoA_betaA_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 13" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="42"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="361"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="13">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="13">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7639551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9521751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="444" mass="48157" checksum="D12521ED5DB6018D" modified="2023-02-22" version="1">MLRSLRNKFILAKQIANAANNNGTGGHTVGRRFLNVHEYVAMEILQKGGVKVPRFGVASTPDEAVEISKRLGENDFVVKAQVLTGGRGRGHFSSGLKGGVKLVYTAEEVREVASKMLGHNIFTKQTGEKGMICNKVMIVERLYPRREYYFAIMLERAYQGPVIIASSQGGMAIEDVAKESPEAIITVPVDIVNGLSSEMAMDVVRKVGFHPNSHEHAAQLVMNLYKLFLEKDASMIEINPMIEDSNGHVLCIDAKCRFDDNAEFRQQDVYDLKDPTQIDQREVEAQAANLNYISLDGDIGCLVNGAGLAMATMDIIKLHGGSPANFLDVGGGATAQQVKEAFRIISSDSKVQAILVNIFGGIMRCDVIAEGIIAAAQTLKLKIPIVVRLQGTNVDDAKALIASSNLRILACDNLEEAAKMVVKMSAIIGLARSAAVDVNFELPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7G2</accession>
    <name>A0A922I7G2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_004495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7G2"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9520803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="332" mass="38768" checksum="21B594FD5929DA0C" modified="2023-02-22" version="1">METLECFGFIITWYIVIRILIISWLWPLLKYVWIIYLQNYNDHNRKYFQPSSDKWAIITGGTDGIGLAYCHQLAEIGYPLFIISRSLKKLESIAQQLREQYPQCPEIRIFQFDFNDNFESNNYDNLEMAIEQLSNIDILVNNVGISYRTAEFFTDITRIEPNFHRSIINVNIVSVLRLTLICLPRMIEQQNGIIINISSLSAICPMPLLSAYSASKACVDYFSQCLCLELNDQYPKIFIQSILPGFVATKMSKMSPSRTVPSADSYVHSAILSIGHTNRTFVFILHCLHYKLYQFSNHCFIDIYRRIAYKQMLKLRQKYLRKEALAKCKRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7S9</accession>
    <name>A0A922I7S9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7S9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9525887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="249" mass="28816" checksum="56DA67409486365B" modified="2023-02-22" version="1">MCQCLSKQDLRKRHRHNKRISNRYNDDNNGDGDDDDNKHNNNNGKLSRCQHRISSTKSSIISINNNDRPELNAFNPAPTIKINLSKIYTSITSIYSNVQKPSSMITVMKKSEHKTPMTPSLKADLPSCDVKTIQVQKNSLRPMRSSIFDWNDERQDKNRHIKLKQSMVIDKQQKFIDAVVDRLIRKRFDGEILRMTKKPSSSSSPSHISRIKKKNRPSKRKMTTKPRQKIRTKMSPSKFSYQSSSSSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I843</accession>
    <name>A0A922I843_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I843"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="2">
        <location>
            <begin position="90"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="239" mass="27791" checksum="2D92767384413D73" modified="2023-02-22" version="1">MYQWYSEQKPFRWPSFSLFSSLFVIVGVVILTNVVISIKSTPSSTTTSSLPVIDGKWQPLLNLNDDTIRQLFMPRLLDLNQVASKWNNVSEACRHDIRHALTDMFDVSPQNRKAWPFQMFDSWSKMPPSGMFRGTITDYGDYDQCLSIIEPIRSQYCLVDFSMPMPKSQPPPNHNFFHKTLGLLPETFPRRNESTIYEHLEKYSSIFYYTYVEMAICMPIVCNQDDLETILKVKQNNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8C6</accession>
    <name>A0A922I8C6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Early growth response protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">EGR1</name>
        <name evidence="16" type="ORF">DERF_006104</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EGR C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8C6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000092">
        <property type="entry name" value="Early growth response protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="655"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="685"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="713"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="235"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="548"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="726"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="45"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="552"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="730"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="747"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="764"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9522540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="874" mass="94147" checksum="78301FF0F6D23906" modified="2023-02-22" version="1">MFFFVGDDAQNKNQTTTTTTAQPRTQSRKEPETTIENNNEDDKQQQQQQQPNAMYSSSISLSPSPTQTSTTTNNTSQSSAANNNSSANINNNNTNTITTHSSTTSTSSSVTSSSSSTTTSLTSSISINRQSPQQQLPASSSAEQQSNILSISSNTLSSQSQSPSLTTTSTITNRDQQQQEALIWSSTVSDVTNKNAQQQYSSSIIPHHTTTGQQQQQHHQLICPSTTTQFIAIPDHHPHHSHQHTHSLHHQHPFHHHQQQQQHLQQTHGHHHQQQQQHHQLHRHHNPHPHQQHHQQHQQQQNPQSISIVTETISSTPSSTTTSSSSSSPFITISGGQLDSIHGTISGDPLSAATSYTQRAEAIFAGTSSSFITPQSTHSIYGNTGTGQSCTQLQTTDLIGGNVLTINGSSSTSASYITPSTLTLAAPAAIVGEDLFISRAPQQQPPPPLPSTTFQCPAASFSTSAAAAASLHKYHATQWPYYTATTSTSTCTPSTLEYSNIVVPGTSLLTTGNIISVKQELCDTESTSYGGSNISTATDIINVTANDPLTNSPSSSSGLILESGSGTGAAETGSSGRESRRNSNQSYSGSTTSGGQQQPQERPATLAEYNQSTSKGHEILSQAYQNSPIPLKLLPVKTRKYPNRPSKTPVHERPYACPIDACDRRFSRSDELTRHIRIHTGQKPFQCRICMRSFSRSDHLTTHVRTHTGEKPFSCDLCGRKFARSDEKKRHAKVHLKQKIKRERGTSGSGGNRSGQRGGGGVSGHSSSSNSQQQQQHQQQQQQQIALSQQQHTTTMSSSIASQLSASLCPQSSMITGHHSGEHLIAGLSSSASTTLPPLPSIMTSSSTICGTPQSSQIIGGGTLPTLHYTHSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8I7</accession>
    <name>A0A922I8I7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8I7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="161" mass="18697" checksum="E40B224D7F2708C2" modified="2023-02-22" version="1">MITQYCDLFAQSKSDVGHINHQHHKIDLSNEMPIFLKPYRTSPREQKIIDETTIFTSPYSFPVTLAEKKGEGKTRMCIDYRKLNDVTVTDKQPIPIIDDIIDKLYEKKYFTKFDIANGYWHVLIAPEDLPKTAFSTHNQHLEWLVMPFGLKNAPSDIPKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8K7</accession>
    <name>A0A922I8K7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DBH-like monooxygenase protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MOXD1_1</name>
        <name evidence="15" type="ORF">DERF_006289</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8K7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.310:FF:000004">
        <property type="entry name" value="DBH-like monooxygenase protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.230:FF:000001">
        <property type="entry name" value="Monooxygenase, DBH-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1210:FF:000001">
        <property type="entry name" value="Monooxygenase, DBH-like 1, like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF23">
        <property type="entry name" value="MOXD1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037460155" evidence="13">
        <location>
            <begin position="21"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="14">
        <location>
            <begin position="39"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9522726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="661" mass="77212" checksum="1905425DA6E73661" modified="2023-02-22" version="1">MDKLFIRFLIIWLSLYDNIGHHHCHLYDWMHRIVLDSNNKYHLKWLFNMKQELIVFNVCVETHGWFGLGISHSGHMIGSDIVIGWIDQRGHVHLQDRFAEDADEMPVIDDKQDWQLESGYENDTHTCITFSRPFLTCDYDGDLPITNDVTKLIWAYNDDDPVGYSAILSKHSHHQRGHRSVHLLNYKFDNNDNNNLNNIKHSSMIKSWDITSKNVTIPHDSDTTYWCKIVSPSFRSKAHVIRIEPIISPSKNAPFVHHMVLYRCLHPNPLMMYDYLDQPGINCLDFANMPFDFFHCQSIYMVWTTGGEAFNLPDNVGIPIFEDHETTYFMFEIHYDNPELKQNIQDSSGLRLFYTEKLREFDADTATMGSVVDYRLIIPDGFENFTISGHCSPECFRQKIPTTGLNVLAALPHGHKHLQRIIVRHFRHHEELPPLAEENNYDFNFQDFRRFNKQRIILPGDQITVECTYNTESLKRPILGGLSTQEEMCMVFLVYYPRMKGVRTCLSGLTPETVMKLTNIDQVQKLDENDMNPVIIHPLEYANQTLSTYVLTKQHWQIPKNTVADIENLTNLIRYAPQKAQCFWRKIEGIDGIEGMDEINELITYPKSYRRYEKPIAKCRPVINSHYTIPPRFMSSSSSLLTVLFPYPFYIIIIIITIFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8T8</accession>
    <name>A0A922I8T8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8T8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="230" mass="26107" checksum="A31CBE1B54AA9BE4" modified="2023-02-22" version="1">MTTCNNNFSLCHQNRQQHHHCFSVVSCPCSCCDYNNNNNNNRMSGTATSCYEKEAQIPFPPFFSSNITLSNSSSSSSSLKPKRSSLNKMAKKIDLNQTSHQESLNDDNNINDDQPGSYHHNHHHHHHLLPYFIMKFNSTFDKLQSSSSLTLSSLTMKKQRKPFLENTCNNRIQKQLQSLLPSSVISYDRKNFLPSPIAIMIIIILSILNTNAFVSDVSFSSFLCRVINIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9C9</accession>
    <name>A0A922I9C9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fabp5p, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FABP5_2</name>
        <name evidence="5" type="ORF">DERF_000731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9C9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000024">
        <property type="entry name" value="Putative phosphoribosyl pyrophosphate synthase-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF53">
        <property type="entry name" value="GH23275P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9526667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="426" mass="47448" checksum="2662C9011C090F45" modified="2023-02-22" version="1">MAGINADMVILTGNSHKEFAKLIAERLGVRLGACSIYHSSNRETVAEIGDSVRGRDVYIVQTGAKDVNNVVMESLILAYACKTSSAKNIVGVFPYMPYSKQSKMRKRGCIAAKLMAKLFCKSGFTHIITMDLHQKEVQGFFDIPVDNLRASPFLLQYIQESIPDYRNAVIVAKDPGLTKKATSYAERLRLGIAVIHGEQKVSDSDQIDGRSSPPPHNNLSTSPSASSSSLESRIIDVRLDIIPSLAEKNKPPMTVVGDVMGRIAIIVDDLIDDVAAFVAAAEVLKDRGAYKIYVLATHGLLSQDAPRLIEESPINEVVVTNTVPHEVQKLQCAKIKTVDISILISEAIRRIHNNESMSYLFRNYFWVMQKKPNCSKLKNLKQSNKLILLSITIDSTEYSIFEHHHITLFSDQFANVMDEFRVNNYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAN0</accession>
    <name>A0A922IAN0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HIST2H3A_1</name>
        <name evidence="8" type="ORF">DERF_001521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAN0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="7">
        <location>
            <begin position="40"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9527510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="132" mass="14914" checksum="1335EF03290503CD" modified="2023-02-22" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB63</accession>
    <name>A0A922IB63_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras- protein Rab-7</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Ras-related protein rab-7a-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RAB7</name>
        <name evidence="8" type="ORF">DERF_001081</name>
        <name evidence="7" type="ORF">HUG17_4325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB63"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7641281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9527031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="207" mass="23196" checksum="70F09EC810BB7010" modified="2023-02-22" version="1">MASRKKALLKVIILGDSGVGKTSLMNQYVNHKFSNQYKATIGADFLTKEIIVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVYDVTSPGSFKSLDSWRDEFLIQASPRDPENFPFVVIGNKVDLDNRAVSAKRAQGWCQSKNNIPYFETSAKEAINVDQAFSTVAKNGLAQETEVELYNSEFPDKINLSQDQNQQRNDNCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBK9</accession>
    <name>A0A922IBK9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Potassium voltage-gated channel sub KQT member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KCNQ4_3</name>
        <name evidence="8" type="ORF">DERF_002452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBK9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF9">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="174"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9528511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="589" mass="69356" checksum="AE8C7B6FD4C9FC9E" modified="2023-02-22" version="1">MDPDNVVEIESINDDNDDEDIGVFVEDQHQNEQNVDHNHDIITTDNHFANEMTVTSISELTPHRLFNRHHNKRPNSSISIGGKLDQKSSLNTESIESSSMQTLSPPTTLQKPITKRLHSLVQLPEQLDARTKIELKAIETAKNKEEIKQKPWSYRARICVYNFLNYPTNIWSYYYHFVIAIILLYYLGLIMFTSRTTWEEKCFRYEKDHRLKSYFELIIFIQFIMEFSLRFWSSRAKVPYKNLNVTQWIFKIFFWPCFVWPQLPIDFTQDLYALIMLRGLHRLFNVIQWTSVQKRDSPWRILLEVFHDGGHLLFAMFYLVLLIIFLVAYGIFLAETNPDHDHNKKDTKIGNLMDSLYATSITLLTVGFGDFSPITYAGQALMGIGIWIALALFAIPSGLIATSVALKVTEQEESRKRKIRKMLASTLIQRAWRFAHRQRQFEMVVWLEHMRRTGQENSIPVRTHRTLWEKIDHVLENRKQFFATQFIQLLLLNRARRKFRSVVIPDTDPRPAMKSYKTKNNDTLEILQKIHQQLEQMVGHHRSTTSEQTSNNNNNNNLSTLEILEINLEQMEQKLSEQNRFLKELLLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBQ6</accession>
    <name>A0A922IBQ6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBQ6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="84" mass="9716" checksum="8685794794F17BAA" modified="2023-02-22" version="1">MAEQRTQQEEIDRQVAAALAHEEQMGRHGSSPWSSPFRSLWPSSWPSWTSPWSSPWSSPWPSPFWSLWPSSWPPWTSSSSWLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBT3</accession>
    <name>A0A922IBT3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBT3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="22585" checksum="5AEA6F59398C74A1" modified="2023-02-22" version="1">MTSSSLSSSVHNWNVVDNLEISDHRIITFDINFSVPTTPDITTTIKWNTNNVNWDQWSTIINDKFMNNNITCEHIRDINNKFDLDFLVSFVTTTIQQACDTTMRRYNRRRIKRHPWHNDGHLRELLHLQKSLYRRIRRCRDINQRTTLIEQHQQSRHQYRQRLNNFTKFDHHQLSYWLTEHMQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC49</accession>
    <name>A0A922IC49_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Thromboxane-A synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TBXAS1_3</name>
        <name evidence="17" type="ORF">DERF_002074</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC49"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9528103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="531" mass="61788" checksum="0495D264902404BB" modified="2023-02-22" version="1">MMDIIIGLINSIGRTGIVIVLLSLLYWYIRTKYSYWKQKGIDGPPVIPFLGNFFLPHKPVALLHQDYVRRYGKFFGMYQGRKPMLCIADPVIIKRILVQDFPMFRNRIKQTTRHKIFSQNLVNARDESWKRIRSILSPMFTSSKMKKMEGMIDQCADSMIQVFGKLADKQESFLVHGVMGNFTMDVIAKCAFATDTNAHNDKENIFVQNARSFFNFNLFRMLLLIITPSALIQLFAKSKIPPYYSKTADFFMNMSSHVIKQRRENKTKQCDDMLQLMIKAEHAKEKSFEKEDAIDSHHVNQGEEEIYQEEEIFREIIGSKYLNEEEIIAQSMVFLLAGYETTASTLTFCMYELAKHPNIQNKLYDEIKTIIDRGETLDFNNIMKLPYLDAVISETLRKHPPALLLSREAMEEYHIPEYKYTLEKDEAITIPVYAIHHDPEYYPNPETFNPDRFMPENRHNIVPYTYLPFGGGPRNCIGMRFALSEAKLGLANLLKNFIIIATDKTCDRLQVEKSLFLMKTTPIYVGVKRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICA1</accession>
    <name>A0A922ICA1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICA1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="140" mass="16556" checksum="DFC9C9CFC3A5206A" modified="2023-02-22" version="1">MNNYDRVLSVIRNLSESRKINNYGKRCNIIKEPQLKKEANIRTPSTFDHPTDLSTAITWHVVHACMQEDYQSIRSSIRRIKTTTKSMNNKTFVWLMTLEWTTIEHLKTEKKKQEQINWKKNCNMAHSNVVPDSKSFRMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICR8</accession>
    <name>A0A922ICR8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICR8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="107" mass="12006" checksum="9A1D0B0F078693A0" modified="2023-02-22" version="1">MIYEIKRVALILLSINFLVIRILNALPSSSSNLLLLSSNFYCIQFSPSKCGGFFVRCHHHQPGASFSFSAVYHNIGSKNSGPRYIYMYLTEFPDSSCENLVSKPYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE59</accession>
    <name>A0A922IE59_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NF-kappa-B-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_003653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE59"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="197"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9529789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="302" mass="35902" checksum="FA4B89B9A31D266B" modified="2023-02-22" version="1">MSTIHRDHHHHHHNRHNNDDDYYHSDYRHDKYDRRNYDHKDNRDYWIKRRKQRESIGRNGVGYIWNTSPIPTDNSETSNDDDDDDDDGNFENINDMNGKNDRKKRKHKHSSKHKSKKEKKKKRKKDKHKKRRHSSSPSPSSSSECNNDDEIKFRTAEEEQFVREFNEKRKLNEKHDENDESDIVGPAPIETLELNNRDFGKALLPGEGAAMAAFVNEGKRIPRRGEIGLTSDQIESFEEVGYVMSGSRHRRMEAVRIRKENQIYSADEKRALAMFNKEERTKRETKILTQFKEMIKQKQSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEM8</accession>
    <name>A0A922IEM8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LRAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_003947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEM8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LRAT" evidence="6">
        <location>
            <begin position="112"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9530116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="370" mass="39825" checksum="0B00030D8A325B0C" modified="2023-02-22" version="1">MVTTTTATTGTSDTITPRVKTLRSFSSCPSTTTAAAAAAASTELSSSNPILNSAIKSTSLDLENCLHSQQPNELIIIDQNQTIAIEVPPNTLKIDLHSFRPASELHPEPGDIIEFDRTLFSQWGIYVGDGDVVVIVGNDAIQMVPDSEIAHVELVPLTIVAGDHYCRVNNKLHRAKERNLLPFNNEIVVRKALSKVGTTVPYNALQCNTEHYVTEWKYGQRWSDQAQVSLHSFKALRLQHTNSISESHNVFVNTLNEVLNSPAISHGSNGASSQLASPTLSTTNSKPIQINSYDRNRSISISESLSSGSGGCGCGSTASTSPPSINLMATNHLPITTTTTTAATTTTTTTMLSESFNNTADNCQTELSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEU7</accession>
    <name>A0A922IEU7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEU7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="144" mass="17103" checksum="6A67378FD93A8BD1" modified="2023-02-22" version="1" fragment="single">MFCSHSFDLFLAVEISVSCYFLLHIQFIHSLYLVDDLNDDEDWFIHSFYRTNNNSMKKKKKKKVQEHSVSVFIFHNEDDVYGVHLLDKKKNKNPKFEFGPTKDNDNDDDDVRPSLTFELRYCYVGIILSIMIIAPVKNTHHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG86</accession>
    <name>A0A922IG86_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG86"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9530301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="124" mass="13999" checksum="B84C515D382778E9" modified="2023-02-22" version="1">MYFGVIYGDCILLKSLTTLLDRPPSTSEPIDVDDDDFCGDIRFAGDGDLPIGCGDCGDELFFSTTTTPRCSVVGRRRLFLPVALAAPYDLLRRKRKQIMMTTIEMIIIIDDTKMVEMNIIHRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IH37</accession>
    <name>A0A922IH37_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IH37"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="78" mass="9183" checksum="8889DEB79A7562AB" modified="2023-02-22" version="1">MKRLKRSKLNENHKEKQKHMFITGLYIVCNRPTEQANTNSDNDDDDDDNDGGHMTYIAIHYKCHSKQQVLNMNELNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KTQ5</accession>
    <name>A0A922KTQ5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KTQ5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="513" mass="58952" checksum="7E8C58596CCB60FB" modified="2023-02-22" version="1">MVLKISIKCGSYGRQFNQTLGISFMNDHVYQLFKDFTTIVYGPLMTHFDHEKHRLSLSNGQQRLSLKQLNKRWKLFQDVDFFSLQQYSQHLKLMEFHQHFGMAIYDHPKLGPTMAIYMKRSSIEYNYEFYTINDPIQQISIERIYSRPTQWILISGNGDAHLILYENENKIPKFQVLNNPLQRSSIGHLCVDSKQKTIRLIKPNNDNADDQCNNDEQESTVQILSTINYGFTYKNQWLYLVSIEKQNVFYVNYQLILSKDDDDDKQRAKNYSLQMKSIRDFVANCDSLVNFDDDDDDGISTNFSHNIDDGADNDSTRFVIQSLSSKNIFSQENRLAIIIITALLLSILLVILLFAIFLISEFYLQKSTATTAIAATKKERHHYHREKKPESELLKPTTMENENNYNNNNNGDENVVDEKTETTTTTIKSISKSSTKQQSSPMIKNVKIRLRSASLSPPQPSSSSAVKSLKLQSLSEISTQKASKTSPSRSSAEINTSKSSVIVEKNEKSKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY67</accession>
    <name>A0A922KY67_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CSNK1E</name>
        <name evidence="11" type="ORF">DERF_012905</name>
        <name evidence="10" type="ORF">HUG17_7687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY67"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000596">
        <property type="entry name" value="CK1 family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="429"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7640220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9502114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="515" mass="56640" checksum="F8F5718004AD45D2" modified="2023-02-22" version="1">MEVHVAKKYRLGHKIGSGSFGVIYIGTNITTKEDVAIKLEDVTSKHPQLHIESKFYRVMAGGIGIPQLKWFGTEGDYNIIVMDLLGPSLEDLFNFCNRKFTLKTVLLLADQLISRIEFIHSRDYIHRDIKPDNFLMGLGDRGNLVYIIDFGLAKRYRDPKSRQHIRYRTGKNLTGTARYASLNTHLGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKANTKRQKYERISEKKISTTLEELCRGYPAEFIAYLTYCRELRFDEDPDYVYLRSLLRVLFHRQGFSYDYVFDWNVLKYGNGNNYQNNRQAGPQRTQASNNHLMSSGNCCNMTTQVIGNNSNTTLSPNVTPLNSNSLQIKATTSGPSGTVPAGAGIGPGNHSGLVGGPSSSHMHPSVPLNLTLKSVIQSSAAMNMAAARQTPLAAQASSSGMQSAGAVGGAGGGPGGDPLHCTNSTVAGSSNGQHSLYRKPHNVHIMPPTHSSIRNLTIYQMSNKNNHCTTAAAAAAAFQSNGALQTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYF6</accession>
    <name>A0A922KYF6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Complement Clr-like EGF-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FBLN2_2</name>
        <name evidence="15" type="ORF">DERF_016036</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fibulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYF6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055088">
        <property type="entry name" value="Fibulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039:SF33">
        <property type="entry name" value="EGF-CONTAINING FIBULIN-LIKE EXTRACELLULAR MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039">
        <property type="entry name" value="FIBRILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22914">
        <property type="entry name" value="Fibulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037703823" evidence="13">
        <location>
            <begin position="23"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="377"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="418"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="503"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="550"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="100"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9491307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="875" mass="99107" checksum="D003059146DACE5E" modified="2023-02-22" version="1">MSLRRWTAIIFLFVISCDLSFNVEIIPKYTSSTGNKPLRFTRVKRCRQGGIDCRTYRLVAPCPPEICGVDNNNNNNRRISQPLQSESVIHETYVSPPITYVSSSPSTSNHRSEYSYSSSASSSSSSSSSSRIISHNHTPIPPPSPSRIIERRIEKYRPQPIVQQKIVQEPIVQQKIVQEPIVQQKVETYVQKTVQRPIYQQQKIIQQHIPIVQQKIERIIQEPPVVQQKVEQITQIKTPIVQQKIERIVQKPVPVVQQKFERIIEEHHHVKSSPQVVQVDEEIHTIIQKPIVSLRITACPEGHYLSADGTHCKHIDCESGFEFSDLLLKCVDIDECTVSTACLRDEQCINTYGSYVCRKICTQAGYRLNEAHNTCEDINECIEDLHSCGPQQQCINTPGSYRCECPNGFRLDGQQCIDINECIESHDHLCPHDVSTCENTPGSYYCKCKRGFEKDHRGRCTDFDECLINNGGCSQRCINKYGSYECHCNDGFKLSADGHTCVDIDECVEYSHTGICSPQVSICENTIGSYRCRCRTGFRDPDGTGKHCVDVDECLEQTNLCEQKCINTFGSYKCTCNRGYRAVGPHRCEDIDECHEGDFINDIAFSRFRHDDHDGHPKLCQGGCENSAGSYRCTCPNGYNLVHNHHCLDIDECREFGYCRGSNQSCVNIGGSFRCIDDRCPPGYHKDGVQCKISQRLNYAEICDDPTEVCAIDRVICYSYAYIAFRSRMIKHETETTIVTTTTKGETKSDIKTGGYQSAVTVQRLKQQPSIGNNNNNGRGHEFFTFVVPVESPIIVDFKLRLVSVKSPRPGVRAANVNDFEMRRTKDNEVRLAIMSSLEGPQDIELEIEAKMYKNGLQIGKNLAIVTVFISEYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZB6</accession>
    <name>A0A922KZB6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase</fullName>
            <ecNumber evidence="5">3.5.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peptide:N-glycanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NGLY1</name>
        <name evidence="13" type="ORF">DERF_014630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue.</text>
            <dbReference type="EC" id="3.5.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.52" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZB6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1020">
        <property type="entry name" value="Peptide N glycanase, PAW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038680">
        <property type="entry name" value="PAW_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006588">
        <property type="entry name" value="Peptide_N_glycanase_PAW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04721">
        <property type="entry name" value="PAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="12">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9493904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="490" mass="59108" checksum="9D84E536DF4F4BE1" modified="2023-02-22" version="1">MPPIDYNRYYSLITDHSFLRLFGQYDNRFVRLAHQLIPWDRFNEDFEHLHNDDNCDKIDRRDYCIIRLLEHFKQELFTWNVIYWNVATQMILNIIVEMIEVYKCPKCNALIEFPRYNHAGRLLETRRGRCGEWALCFSYICFVFDYDVRMVHHVDDHVWVEIFSEHQKRWIHCDPCENAFDNALLYECGWKKPATLIIASGMNEIRDVTWRYSSEWQKTVMLRIQLFDENRLQSMIDQNNRRLQSNLSATERDRILHRWIGEMVEFLRTPDQNIRQPSDPKALQGRISGSIQWRQSRGESKHSYHEFHLNRRYCQIVYNCQRDEYSISNLDSKEESSSIKGWQSGCYESAYIFRMIEHDWQMCYLSRQQYCGQQVIGSIRWRFRLPNANVEWNQINILVKGRTYESGVIELHVILPSANDHLSFELNEMFQLNRNDFDHKIEWFDIEAKLMFGEGNIAWQHAQLFRQKLLPQNNNESDIDDEDLFKICIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0W7</accession>
    <name>A0A922L0W7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Pyroglutamyl-peptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PGPEP1</name>
        <name evidence="8" type="ORF">DERF_010664</name>
        <name evidence="7" type="ORF">HUG17_9692</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0W7"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7643001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9505897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="235" mass="27227" checksum="32B908C95C86740B" modified="2023-02-22" version="1">MDSKKKENVVLTGFGLFRTYTMNPSWEAVRLIDEQKFDCSNIELVKIQIPVAYDEVEKCVKEIWKKYQPKLVIHCGVSSMARNCLHLEKRAVINKERYCQPDIMSCLPKCCPNDHVDPSPKPLDYVCTEMHLESIRDEINKHYYDGHIMIPAKISDFAGEFLCEFIYRCSLQYDCHRTLFIHVPDINRDLSIEDIAKCLELIIHLALKQLDSGSSGFYSSKSNKQSRIQSNAIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L172</accession>
    <name>A0A922L172_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L172"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9438" checksum="435C0CF0D2919935" modified="2023-02-22" version="1">MWSLDQDYRQPELYQTSTSIFKSMIGDDDCLKILYKGAVMTGACCGQTEVYNTSIDYVRQQLYSTQFNKNALCERRCVSDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1W6</accession>
    <name>A0A922L1W6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PIH1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1W6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="138" mass="15943" checksum="D2B06F8DCCE6D5FF" modified="2023-02-22" version="1">MNEIGSIISNREHIHTKEPGFLVKTHCKRDKVEFFINVCHSSAISAPTIQLDEKDLHDLIAQENYQNLSYLCHIIINSKNSNNCDGKLIIHTGSVSLHNDKPQRFSILVRKIKNRGQEQIKRTEFWVSISHQHKDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L270</accession>
    <name>A0A922L270_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Frmpd3p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FRMPD3_2</name>
        <name evidence="3" type="ORF">DERF_010090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N-CoR nuclear receptor corepressors family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L270"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="710"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="618"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="723"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="900" mass="104068" checksum="81106C71E6C9A1EC" modified="2023-02-22" version="1">MKENLKQLIERSTLKIQWELPREWWNDGAPRYYGHHNVLASGWNYVPSNNNDGNGQRKIHQADLSIPPPYYSTKMVNLCQQKQPKMMIKSMEIRNPTKIPIIITTDLTANKTTEIIESIDSRDSLLYTMEEMNKNLEDQLINRYDGRPLSVDMPSLISMEILESHGPGRQQIDDDVMVMKSESKWQQKQQQQQQQNVDQVLQNVNEMNRILNDTEKYLDQMMMNKKSTKTEMNEKNIIPDLTSDHHWNHNHETETATKTKQSTLLSPSSSSSENNDMLLIPKLLQAETDLLDAMKSLDDVIIMNHDNDKNESTNNVENDYRLDLVAIPPPPPPPISGNIKLDDAQAQPPPTPYKELAEIFQPLIVIDNETTDSSLDQQQQQHQQQQTQNSQERVVAELDMLCDSLMAMKSQNQSSLLSSSTQMVTICNDDDNNNHTIGINNNIGGQQQSSSYDSSSCDEAIISRSPSKTPTIIINDNDHDEIEEFINYSNLVIPPPPSSSSPLESSLMLQEQLNVIEKFRQATDDVKKMCTLYHDVTTDNNKQQQPELPQQQQQQQQQQLDDQQLFHHPQHEWLQQLAMAVHQQQQQQILSDSGNNNNRQYYYCNIPQQYSSLPTLYNSNNQQQQQQRQQQSSTMDESTLNQQNYPTNDLHSIILQYQQQQQQQRMDPNGLISKNITRSQSLNQFDYQQQRQRQQSNCYYDKKMAMMTPQPSPPMDIFHHQKQGPLQQQQQQQIQYKQKPPLPPSIMVMKEKHRLRQQQQQQQQQQQRKNENFEQQQQQIQCSSQSIIDQNNQSISMNIGRRSPPAYHHYYHHHHQQQNSPQDGSITPSSIEDAYMNEAALIAAAMQQSSTSSASSSPGPITMVNNNNYNYSTTLFGQQQQPQQQHNNNNNKFIILLIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L283</accession>
    <name>A0A922L283_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Down syndrome cell adhesion molecule-like protein Dscam2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_009112</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd20956">
        <property type="entry name" value="IgI_4_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056754">
        <property type="entry name" value="DSCAM/DSCAML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF100">
        <property type="entry name" value="FASCICLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25059">
        <property type="entry name" value="FN3_DSCAM-DSCAML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1583"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="318"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="455"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="575"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="687"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="776"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="882"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="1007"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1130"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1340"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1754"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1754"/>
            <end position="1769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9510591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1816" mass="203472" checksum="FACA94C400E06CEC" modified="2023-02-22" version="1">MAIIINHQSFDYLIILSFAFILFDDFCCLKISSIKSSPQSINANVQQQKRGPEFLIEPPGIITFINDTGTVITCSARGQPSPKIYWIYATIATENGIGGGSMMNHLIPVDGLQQIRHDSLASQLIYLPFKSNQYRQDVHSIRIRCIATNQFGSIQSHDIQIRASVRQPYDIQVYDDFVIKENTGILRCHIPSFIREHVRVTNWLRHRDDNGVVGGGNTAGDQIIISDLIKGGRYSIMPNGDLHVHYIQIDDNDRLSSSSSSSSSSSTSLQSSSSFSSSTTIKTAMFRCQTKHLLTGEIKQSANYGRLIVTDAQSRMPPKIIATIGYNNNNGGVSSPTNKNFGYNRKQKVIANFGDIIELPCLVQANPWPTFTWYRMNHNNKYSSITQPTKFNDPQHQSSSSLLTPILSGAKKIIQIDSSLFIHDVSLLDSGIYVCIANNSLGQDRIETELIVKAPLHVQIIPSIIKAIDGDTIEFNCTISTGSRNINIDDGNSLIDRIRWYHNTQLLTMMIPSTSSSTTILQENLDSRYRFLDHDHILQIRNVGREDKGMFQCIVSNEFESIQATGELSLVDDPPSFVSVFNIAEPLRPGKSLSLKCSAIGTPLPQIIWTLDGQTLQEHGRIRVGDYVSADNVVNSFVNITSLRSEDGGIYSCTASNDIHSISHSSRINVFGAASVRSMKNFTAIAGHNLQLHCPAAGYPIESIEWYKKSTNHMNDIHQSSINRLPQNHRQKTFPNGTLIIERIERGSDDGEYRCQVTSESNVASADTFIRVLVAPLINPFHSPPNLREGMRVMLTCSVVEGDPPLMIQFLKDGIPISMKQQQTTSALVENHHMKFDRTNDYSATLFIESVTNEDSGNYSCIVSNNAAIATYSIFMKVNVPPKWIIMPKDIEAIEGQNIAIDCSATGDSRVWWERAYEKSLSPPMHSKSTLLLMKNSGNHNISKQQQSPTMNHFRTVVSNSHIHTAENGSLIFRDIQYDDSGTYLCQANNGVGSGLSKVIKLKVHVPAYFKNKFSSQTVRHGESVEWSCEVNGEQTIDLQISKDRMILDFVPINNNEDNSLKSNSDTKILHSDNRYNLIRKLQNDHLVSYIIRIDQVDRRDSSLFTCVASNPYGKDEYNFQLIVQEPPEPPENLHALEIESRNAVIAWSQPYSGNSPIVAYHVEYRLWMDSSTSWSNVHHTSNQSTIVEHNTAAMMSKSLLPGTIYRKTLPGTETSINLRSLQPMSTYEIRVQAENQIGFGSFQLTPLKIMTKEEAPSGPPLNIRVFPISAHTLQISFQPPRLENQNGQILGYYVGYKARLNITDLRRATKYVIIVQAFNRIGPGPQSEEIVGETLINDPPRAPVLTSINVGYNSVELNWSIETMDDSFDGGLHVSSKFDVPEITGYYLYSKSPQGEWEERHINSEENSFKYNNLLCGNQYQFYVIAYNNIGKGNPSQAISVRTKGSVPIAPKDTENIDHAWIRLDQWLVNGCEIKYFLIKYRSKIDKEWLAISSKISPNEQRLVELIDLHPATWYILNMAAITDIGTTEQTYSFATLTIDGATLSPLDTPMLMQASSGIGYPSSSKTSTTMMTINPIQSMTILIPATCSVIVLTVIILVACFVIRIKRQQHFNHTLGDGATGGPDDEPNNSNVQILHSTNINHHHQGKEFNNDLPRYVHPIGTKNLDHCGLCDGNVGVKHLMKSEYNTHNNNRKEDIEMLDNGQNSSDPNYATLKNPIHLMRTQRTACIKSSKLRSTHHTMMMPMKSAIKNHNPNGFGLKNQTKNRISNNNNDNNHHQNDNNQNNNNNLIANTKPNISPMIWLLVSCWKLNLVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L339</accession>
    <name>A0A922L339_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L339"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="9702" checksum="E7D6B869F78AD4C9" modified="2023-02-22" version="1">MSLWSIFKNLHCGLIISFNYKTWSLGLYIIQTNTTSSEFKIQNRENIKSKLTRPVQNPENDKSKLTRPVQNSKFKIEKITNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3D6</accession>
    <name>A0A922L3D6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spfh domain containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_007641</name>
        <name evidence="4" type="ORF">HUG17_2005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3D6"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF130">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="76"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7646467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9516928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="377" mass="44214" checksum="5FF8B5F8D123F4FD" modified="2023-02-22" version="1">MAINDYNRYDSIPVFDYSSPFTYKRVRDVDDDDYDSEVSTRDGLFQRSIYMFIIIITVLFLILTFPIAAFFCVRRIPSLKRCLIYRLGRRLPLKGPGFILLLPFIDKISIIDLYESRFDLIENEQQFMTGDGSIIVVKPCHATLNVTDALLTTLKINNVNVKNFLQISFTNLIRSKHVEDLENKLDFILKEFEEKMNQFMKRWGYAITMIEQPRITVIDRADPINPIKKKLQKLLDNDPSEQSSNPQSSGDFSCLFNMFDNLQQSSLINDQSPQTVSDETMDKSSSLMEYQLIAVVQTFFDQYKTFLGTDKNFNVKLMIEDNDKPMVKYFHCQQDGNVRLIENEPIELNMTVKFKNQADFHRFLTTRDHKYFNFKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3H9</accession>
    <name>A0A922L3H9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC protein, sub ABCG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">wht-4_23</name>
        <name evidence="11" type="ORF">DERF_011859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF91">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1091"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1133"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1167"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1196"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1273"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="17"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="706"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9507161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1330" mass="152894" checksum="A2C714666977D011" modified="2023-02-22" version="1">MSNETDVCCEFKKPISLCWKNLRYEVDEWCMVDGWQPRRRRKIILDRLNGSVRMNSLNALLGPSGSGKTSLINCLIGNVPAKNISPDTEIYINGEIITKSSNSLVSFVPQFVHEIILGRFTVLETLYYAFCFKNPAQYHGQAYQHIQSTIQELMLNPKVLQTRFENCSGGEQRRVAIAQELMSIESKPPFLFIDEPTTGLDSESALVVMKCLQRLSTQNGITVLVSIHAPSSDILDMFDQLYIIAKGGVCIYSDQPDRLRSHLNQITGIALNEDDSPIQEYLRIASNGINDEQVRKLTQESVQQDHQQLTVQFSKFEKEECPFASIPKGIPHYSRKFRSSDLWTQFRRLLRLTFMADVRNIILVIVSSTINIILLTSIANKDMVIPSGCLPFNIDQFNQTCQEKLKEDRLIGTCLMLLIMIMILTLSLGLGMYSIMIVNFMKILRNEYRNGWYSFASLIHPVQLNDMITSILIVVIFIVIYYLNCGILIVEQYQINWYRMGSGSLFTLVIVLYGQSFGYLLIATCIDQFELLLLLSQVILVILNASNGLIVTIDLMDKPFHRTISHLLGSRYIADGYLYTYYGIDRCDPQTEYSQILKQFFVDTDHVYSNLEKPMIVIIVIRIISIIVMRWTFSNVNNGKIVSETKQEILTKILTPAIEIDFHEKSTFVQILDSNNNNVEPEMTKNEFQQFCTGRYIIGWRQLTLFATDTIYEVRPTPESLDDLGDKLILRNLSGQFQFGTLNAIMGSSGSGKTSLLKVFNGKMKTKLTGSTQFYLSRFVPIRTCYIKQEVSKHLIPGLTSKQSLVYASKLKNCHETQAIDHEQVADNLLNELDMTNTANTLVQNCSGGERKRLALAMELTSVRMPNLICIDEPVSGLDSNSARLVLRCLRQFIARHPDITMVVSIHQPSTEQLDMFDLCYVLAFDGLGIYSGPPAQIKSFLSEASSIDEDKRFPIETLIRYSCTGHLNPIVQRLAEETDNQINKITPSVLLDTVHIKDGVPFPRMRFSLRSVAILFHRLAHCSIRYQWPLWLTYLIFYVFLGTMFLDCFDKKIVNIDGCISIEDDFLAVCSNFTDHKWKNDFRLVSNVNFVIFSSFIFFFILDAQIINLFSLGLKFFATQHLNGWYTCGSYYLSKLLFDATTILPMVIIFAYVIDIYSTVSPNNFFWWQVINLYLSSLCFLAIMNMNVLFLHRSILALFTFVGFSQGFFLLLSNVYNVIEEMNFIVRFLSNFSIYRYQFQATLWLIYGGDRCKSHEIQSLMYMLNIPTNVEYFYDCIVKLVLLVIFYHTMALFVFCVKYNPLINRQERAERIERYRNEHILKIEPKHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4H8</accession>
    <name>A0A922L4H8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4H8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9654" checksum="3CF6DCAE1A4721E6" modified="2023-02-22" version="1">MLVTINQKTIATIIIFFNPAEVHFYEEKEFSFNQLKQSTTGRSHKNRLIDHYVNLITPSQNLDMDFRCTLSSSLFMGRFQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5U6</accession>
    <name>A0A922L5U6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_007274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5U6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="9">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9516539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="44" mass="4929" checksum="0827017A3DACB7AF" modified="2023-02-22" version="1">MKPTSMNETDRLIMNQLCKVCGEPAAGYHFGAFTCEGCKTKFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L641</accession>
    <name>A0A922L641_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbonic anhydrase- protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CA10_1</name>
        <name evidence="4" type="ORF">DERF_004343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L641"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF208">
        <property type="entry name" value="CARBONIC ANHYDRASE XA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9520643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="481" mass="55302" checksum="1BA3984118D843D0" modified="2023-02-22" version="1">MIIIRPDFWGRLNPKWSHCSKGQRQSPIDIDTSTLLFDPYLEPIKINGDYVRGQLVNTGRGISLLVDRSTTSSGGDKHVTISNGPFSYQYTVSNITLHFGRENDRGSEHTIDGKRFPGELQLYAYNSQLYSNWSEAKREPNGLVAISIFIMVSGHPGGQMVTSNVGVNNNDNHHHQHNHQHHHHHHHQQQQQPPNAALKQITGLLKNITKRGLSYQIESLSIMDLLPSSWKHYVTYEGSITQPACYETVQWVILNRPIYLSSYQFHMLRHSLKGDGHQDNFRPTQPRNKRSIRCNIVYENIGGTGDDGNHHHSSNTMISNDIQQKQRKRSSSSSSLNNQELNRMADHHHHHHMDNNGTNESNLEFDHKSQTNKWQTIKIKREKQNSFVNHDSDYDDNHNVNVEYNVQKLSSSTDMDSNNNNNDDDDDVDDNVIDNNNQINQFAANLLAVKDEKFCLPDQLRLYGYRGDGCDDRYLWKPIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L757</accession>
    <name>A0A922L757_DERFA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_005440</name>
        <name evidence="2" type="ORF">HUG17_3558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L757"/>
    <dbReference type="OrthoDB" id="6514959at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7639525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9521813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="318" mass="37326" checksum="314DFB3B48C45BEE" modified="2023-02-22" version="1">MIRQYRAFEDLEEPCFLVPEPEWITVTYQMKSIICQWRWDEIRELVPKKLSRPIKKKKNVDSTGGGGDSESLKDLHHSQIQIRPPPTTNVSNSAPASPNLRLNNTKHLHVPSTQHHHSHVKDPEKILKKNLLKIEFLKKPLDSQPMQQYQQTQPLKPKWYRFDSREILDEFLSDANRHGYIERLVRTRWFMTKVKYIPMCHRQIKYNNDDDNKQNSSNDHQNGKTKNRTNSSGSRESSSSSSSSDDNYNDKQKNVKKKINKTQRQKQEASSNNTPPNNNGHMFDYNGDNNIMKAKDFLQKNKQQQQQQQKSKNGHKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7I0</accession>
    <name>A0A922L7I0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7I0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="88" mass="10491" checksum="624210D83AA124AA" modified="2023-02-22" version="1">MKKEKSYLNIPIQREFEVYYESAIITEIFEALDRLIGFAWRITIMMIDQQQLKGNDTFTFSILRDHVDELRILTLIRSPTCLSQQSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7X0</accession>
    <name>A0A922L7X0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7X0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8504" checksum="779F0E90835B04D4" modified="2023-02-22" version="1">MFSNPMHGFSVVTLLNEWSINVQPSWNIISSMAMYGSTKLSSVRFNDASINNLYVEFEDSERKITHCDQNARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8K4</accession>
    <name>A0A922L8K4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Atp1b1p</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="19">Sodium/potassium-transporting atpase subunit beta-2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ATP1B1</name>
        <name evidence="20" type="ORF">DERF_001343</name>
        <name evidence="19" type="ORF">HUG17_4545</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">JKM2019</strain>
            <tissue evidence="19">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8K4"/>
    <dbReference type="OrthoDB" id="5912413at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1660:FF:000004">
        <property type="entry name" value="sodium/potassium-transporting ATPase subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01107">
        <property type="entry name" value="Na_K_ATPase_bet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00390">
        <property type="entry name" value="ATPASE_NA_K_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH7641501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH9527321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="312" mass="36336" checksum="6D970CC807447F4C" modified="2023-02-22" version="1">MANKEEKYCDKQSGWQKFCKFVWNSETGQFLGRTGGSWFKITVFYIIFYLCLAAFWALMLLIFYQTIDYRSPKYQLAESRIGANPGLGFRPRPKDENIDSTLIWFKNGNNEENWKYWSESLQEFLEPYKKSTIDAGAHVENCGDNQMASEGKFCHFDVNAIPSQCSVENHFGYQRGDPCVLIKLNKIFSWKPEGFTDEELRDTHIPDVVRKSYPTRLNNASQLIYITCEGENAADKENVGEIEYYPQQGIEFKYYPFTNQPGYLSPFVFVHFKKPQPGVLINIECKAWARNIKHNRMDREGSVHFELLVDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9I2</accession>
    <name>A0A922L9I2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_002309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9I2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037126535" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="377"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9528356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="443" mass="51040" checksum="944F22DA76FF47F9" modified="2023-02-22" version="1">MSLWLMIIFMIITNSHALEPDWRDKIFGRSQQTMTTPSIPLKVMPTRTYWSISPSSPSSSSRSQSQSTNSFNTFRTSSANYLHHQQPRHGFHINFPTTTTTSSYHNNFARSQPFFISYPQTESPLSASNSYDWIRELIQTRLAESKRHLTQVEESMEKLKTKSSALTTIPTTPPPTITTTTTTLPTITTTTTATTIPDHNRIDVDYADQLVVENRDENLDYFDQQTRTNSSLKPGQRSEKIKGQKFAQTIQMNNREAWKQLMQLRSSQPHPEAGEILAVDPISNTTATTNEENVSHGITSEENNNNSESTELEPIDHHQFNNESGETRMEIDDQHQHLMEESRRMNDMDWDLLPRSINSLFGFEFNSTIKINPKTWTFQCPDNVSGFFADLSSDCQAYYHCSGHRRERFRFECPTGTRFNERSSNCDWQHNVDCHQQFDLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9M9</accession>
    <name>A0A922L9M9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HIS2B_2</name>
        <name evidence="16" type="ORF">DERF_001686</name>
        <name evidence="15" type="ORF">HUG17_10447</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9M9"/>
    <dbReference type="OrthoDB" id="6537802at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        </source>
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        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7636477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9527679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="125" mass="13924" checksum="F9293F192C6090A7" modified="2023-02-22" version="1">MAPPSSTGKAVKKSGKAQKSVRATDKKKKHRRRKESFSIYIYKVLKQVHPDTGISSKAMSIMNSFVNDIFERIAAESSRLSHYNKRTTITSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2023-06-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAE1</accession>
    <name>A0A922LAE1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="11" mass="1400" checksum="04E1155D4721E73B" modified="2023-02-22" version="1">MYHYLHLNPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAI4</accession>
    <name>A0A922LAI4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sterol regulatory element-binding protein 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Sterol regulatory element-binding transcription factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SREBF2</name>
        <name evidence="14" type="ORF">DERF_000786</name>
        <name evidence="13" type="ORF">HUG17_8525</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7641056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAI4"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11394">
        <property type="entry name" value="bHLHzip_SREBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062:SF1">
        <property type="entry name" value="LP12374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BHLH" evidence="12">
        <location>
            <begin position="356"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="438"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7641056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9526722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1180" mass="133898" checksum="9AA39F06A8123B41" modified="2023-02-22" version="1">MDRQSQQQQQQQQQQLQFDLFNLNDDFLDQNLSSMMMMGDEHNPMEFDPTLLLQDENFDELFDSISLTDQQQKNISVNDNDLGMLMQDLSDNPITTNNSFIIPQQQQQQQRQSISANFQSQNFSQQQYHSNPNSSQQFQIFPQQQQPQTQNMTGNVPFTFGQQSQQDAGFKFSMPFNIPPEQQQQQQKPPTQQQQTKVQIVKPTTILKPKNHPTQHPSDVPLQSAAQQLHIGITENGQTILYQLPTNAQTNPTVVQVKAEPQEMIQPSQSVLIQSSNGPILTYRLAGASGSFAAAAASTPVLIKPATTAVQPQPIKSEKIDGGKISIQPLVSNNNDSMQISNCASPQQQQQHQQPEKRSAHNAIEKRYRSSINDKILELKTIIAGPDAKLKKAVILRKVIEYIHYLQKRNQTLETEMNVLKKRLESVGLSTMTTLADISNNNQQSSTTTMLPTSPGSVSSLSSSSSSSIMSPASSPSTIQKPPTPPSFYRDPSRLMCFALILTVVTYNPLGSVVEKSSSLVNYESNHVGRTILSFMSRTTDYDATSFSTSFWMRAFNFTIADILIWLVNVFVCYRIIQMAYYKSHASSGSQQQHRRLNYDHKVHNQSLSNGNQALRDGDIGSATGCYLQALKEITGQSMPIESTISQLYWIARAIIMLYWNETIALIQSFLPISSTTTDDWKSCKFCASSECDQIIGQRIVCYLYGRLTMVTLLKNQGQPSLLSYVYAFTGINESFRFDQNQQDGKSQRSMAYLLTAILLKPQHNIFARYFWHKSYATAQSTKVAQEQFLLCPLGRRYFMKPYLHWSYAFDKPSIFIETKSTVTSMMAFIAAKYRKYLIKKCLLTMMNPRHGVNIKLREAEVAPSITKTGKMEHIPLIDLIDELAKNAEQFGDETSLWWSQVIRIGFYFLTGNDQKAVEIKCRFPSSLRNNLLALSLMFASCLKKYVSIDRHSGRWNSIKKIGHFLQLLDRASYELRKSFEANSNNTINGGDVCDDCHVQLVEAFQLLALDWILSSRVQLWQHFQLLSNQVEDQQQQQNNQKQLSTIRNYSISAFGQDLKVLRYLSQSMMSSARTKLYYYEGVYRLISGASPFEAQLLFGRALRKRNCGHKSPKLICSPGTHDEPPSSLSDIDDYARSLQMSATYMPDQYFISTGERRGLIQEMKSLRAQYGRSEHLIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB33</accession>
    <name>A0A922LB33_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB33"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9691" checksum="8FA905D5972EC02C" modified="2023-02-22" version="1">MDFFLLLPSFVMGCNFLSSSLSSFFVVKAAKKGFGKNIPNKLTMFIMMMMIVNSYRKEFHSRNLFPFHYYIYDIYGIYIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB55</accession>
    <name>A0A922LB55_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB55"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9530171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="419" mass="48358" checksum="4D1DA26B5035B0CA" modified="2023-02-22" version="1">MEKSTRIFKQVVGMARSRYGLGPRIIKMLYDTILIPTLTYAASAWSHAVIFKYIEKELRRFQRPWAHLITKSYRTASFIATTAIADIPPLHLHIRFLANVNLAKIGRNYPYDGRYIATDVEEDIEVKSVESMNIFAGQPLVRSRFHIFTKIIKKNHGIGCCFTVMRDMCMVDVQRFRLPPYCSMLQADHFIMLQAIAWGQEYCFAGTPITVTSNNIGAIKHLKRKNKKISNLAREIVNRLTENITIAWIKVDIEDQQMVKTKKIASRISTSNLEFSFEKIPMSFVKKDQRKILLATWNQEYVSDKFGRSIKSLFQTVGQVRKFSPYISFWLTQGLTGHGQFGKYLKEFGLTSDASCQCGHQEQSVRHLRFECPLAAFLRRDYDTAKNMCMSPVERIRIEAVLYEQLAMLANQLRGGIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBH2</accession>
    <name>A0A922LBH2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_001812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBH2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037150282" evidence="3">
        <location>
            <begin position="20"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9527817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="780" mass="89062" checksum="E2E6B4C3683EEEAF" modified="2023-02-22" version="1">MPNLLRLTTLIPLLTIVCAESPSVTINVHSSEFIDPASYASSNFDLAVLCLGYFQFGYSNPQPYLMQKLHQRAKLKQFLKKALTKLHLTTSETFYRQMTLKAFSKSIAQRQSLLNSVSSSSTSLSFGEMAIHQLSDSSPPNSFDTALSTISRVDKPCSDQIIQQSMATTQNLFQQIAMNHEQHQPDEQSKKMFQSLVAAQETIQKMYLLMQQQQQSNQQQSRLAEHHLNQPSQHHQSYQSEHNYFHQPQQHQQSVNNQEWPHQQSQQVEQKQSQQQRKQEQQQQKSEQKWPDQQQTVNQTSQDKNQSDERIQPQQTIMVNQLGKSETSSSSASLTGNDNQNHQPDHWTYANVEKHVFNNQLNHQRKMVCSSSASLTPSMSTCECASPVITNLVDQACSNWPSNNIESSINKVSVIGCTSYQSSNLKYGLNEESNKSLYSSIGSIRQLNPITKTCAYPKKYMFNQHYSKQQNVEINRVAINKIESTATEFIIIVGKMQQWPNFKNSSSNQLLSSYQLSSSYQSFLANQYSLVGINNDLENRFVFEAHKIVSSGSRLSTCLAKSNIKELINQPSSRNILSSANFQLHSIFNPNQLYCFKIGSISSFSSKQILAINHHFITNLILSFHQILAAYIENLAKSHIFKHHFNIANFNIILSNFNFKFIILANILFILAYLKFLSKYFSWFKFKKKLFIIYCSNHPVQSTLESSFNSINNMEISSIIGNHSLKNGNLAHQLSSIFVNLIPHSFQLSKFLNEHLTNHSALMINIIFVKKISLARLRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCA1</accession>
    <name>A0A922LCA1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCA1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="456" mass="52219" checksum="EBAC00061A20E584" modified="2023-02-22" version="1" fragment="single">KFCCCCCCGIINGSGNGGGGGVGGSTHNGNINGCIIRSRQQQQQQQQECEQGSGVTNTDNNNNNNIGWRSQITPNIVIIDEDDNVDLNNNNNNENEYDEQQQWPSSSTSMITKIQQGSRMVTMKNLSLQIPNPNYDNYSDDDDDDDTDDIDDEDNDDDDDDEYDYDDDSDYSEDDGSISIDENANQSNMIDGCNKNNVHQQQQQQQQKQKQRIKQQNYDDDNNNNYQNIDNKKCKRKSFEIKNLWFYLRHHKNHSSNCITPSSLSSSAIQIVTQQQQQQQQQSLSSSLSAIRPNLQQQQQFRNSSIPETVFLGSLRSLSFSINNQQQIKHSRYSVPTIIQKDKAQKSWERMMRMKNDEKRNKRKSSRLLLSSTSSVQQQQQQQQKQKNNVINTNNNNNHHHNNKTNVVVIIDESSPTKILCIDSMESITKLSDSIQQKQSSTEQNQTFKKQNVFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCI4</accession>
    <name>A0A922LCI4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kelch-like protein diablo</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KLHL17</name>
        <name evidence="9" type="ORF">DERF_003393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May have a role in synapse differentiation and growth.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCI4"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF475">
        <property type="entry name" value="KELCH-LIKE PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="BTB" evidence="8">
        <location>
            <begin position="43"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9529512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="621" mass="69889" checksum="484B4C978016FB6A" modified="2023-02-22" version="1">MMENLTGSRDNICHNTQMNFEDTSHIFTIFTAMNEMRKIGQLCDITLEVAGTKILAHKVVLAANSAYFNAMFNSEMIEKSMSHIEIREIDPNALKLLIEFIYTGQLTITEANVLNLLPASSLLQLMIIRETCCRFLLNQLHPSNCLGIRKFADTHSCQELQVCSLKYALDNFQEVSLTEEFLSLSYEGIISLISDNHLNVADEETVYDATIRWIKHDSKSREIHFPTLLSHVRLPLIERNFLINQILAEPFVRENNQAKDLVIEAMKYHLSFENRSGNSPRTQHRKPDGLTEFIFAIGGGSLFTTHNECEFFDPRDNTWLEFTPTNQRRSRAGVTCLHRYIYVIGGYNNGSKTLSSAEFFDPLTNVWTDTTAMGTKRSCHGVAELNNIIYAVGGYDGINCLSSAERFDPLISAWFSVNSLEIKRRYTRLLALNGSLYVVGGFDGANHLASVERYDPREGKWIAVAPMLSRRSSCGATVMDNKIYVAGGNDGTLCMSSAQRYDPVRNAWENISSMQNRRSTHELVEINGLLYALGGNDGSNSLNTVEFYTPEDNKWSMNNSMILRRSGLGAVKLECCDLRNSLTDSSNLEKSSPYSSLISTKSLDLNFKESNVSNSDDNKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCU6</accession>
    <name>A0A922LCU6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Cytochrome b5 reductase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CYB5R4</name>
        <name evidence="8" type="ORF">DERF_001124</name>
        <name evidence="7" type="ORF">HUG17_4358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCU6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000001">
        <property type="entry name" value="Cytochrome b5 reductase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="70"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7641314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9527080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="152" mass="16369" checksum="EDF56575E439BF04" modified="2023-02-22" version="1">MNDSNKDIPRASLNVSTTSTSGGGGGNATGSGRTKVALKPGYGLMGWVRFTSNSSNLTGIQPKSGNDPRTNIITMIELSKHDQPDDCWIAIRGKVFNVTAYLDYHPGGMDELMKGAGKNATSMFEDVHSWVNYESLLEKCFIGRLAGYDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LD14</accession>
    <name>A0A922LD14_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LD14"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7814" checksum="43B3ABCCAC2A094C" modified="2023-02-22" version="1">MNNVTANNVVTKPGRCSVLAIFFILDLRAFISHWLYLYFVKQPHTNRIRICNSIILMDDYTLILSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDE5</accession>
    <name>A0A922LDE5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDE5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="118" mass="13004" checksum="E0CE24391CBAD16D" modified="2023-02-22" version="1">MVTKCNDIFLTKQIITSMCHIKESRLGYPSKLKPFKKSISRTASIKAPPSGTSYNFPFSSHRAPDNVFNITPLGFQLNLYKSELSADSGAGIPPQNDLNDVILPPFECTCSKHSIANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDL7</accession>
    <name>A0A922LDL7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDL7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="436" mass="51514" checksum="73CE5B62628C1736" modified="2023-02-22" version="1">MSNSSSTVTVHRFAKIHDLLSKTLASKKSSKTNNINICLSKQSPSSSLLYGLRDKIKRNEFSKVEQILASKLKFINKTNQLQYDSSIDDDFSLNTITTEKDPKQPLFEHGDKMSLSSNDSDIYDDDTERKQNDMVKNLEERYYLENKCHEIYLVRRQITNLLKEFYKNCLAKPKQMGKYCDNLVHAHKCLLIAGEEQKLIKRQIEMLKSNNNKFKNKINKNNNYDNNLQHNLFNQKPCIAIKSVSIKLREPRFRQIFLRDQTGCFLICLIEHEYRLREKPIIFINEVDDQFKDSITIDINEILDTDKNDFNVMIKFFFMFHPIDVRHQCRHPKHEINWKKFIPIRGLMAKIMCTNRIFQWKKRQLDLKQIDVISVAHCLDQQPMTSSFTLLGQLKLDHSNVHRQTFRLEQFNHCSIFDSEIILDSELSTDNNNEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HHT7</accession>
    <name>A0A922HHT7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HHT7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6974" checksum="A61FFD8B23C7C687" modified="2023-02-22" version="1">MSEFCKSARQDTLFSAPNLNHMMMDSLSSLTGYGGHRLICETNQIGFGEIFEKKRRFWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKT0</accession>
    <name>A0A922HKT0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_015934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKT0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037134411" evidence="2">
        <location>
            <begin position="28"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9491203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="220" mass="24796" checksum="4A423F061B5017D7" modified="2023-02-22" version="1">MKFHTASLLLLLLSVAMVVIMTTIVSADIEIDKTEVVLMEIVEEMIRQARQSSTDSTIISIGNKIKTLVLTSGLSNRGDLQLMIDLIRLTIDVATMRFCPHSICCCHHRRRGRRRSITESIDDESQSPSLSINNEQSSSSLISKAKLVDPNILNSKSNDKNVKNILMMESNTNISNNNKSNHHHQNQNDNTDPMHMAMINARIRSISLYLAKIQQSVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKZ8</accession>
    <name>A0A922HKZ8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC-type glutathione-S-conjugate transporter</fullName>
            <ecNumber evidence="11">7.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">mrp-4_4</name>
        <name evidence="18" type="ORF">DERF_016002</name>
        <name evidence="17" type="ORF">HUG17_3954</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.3" evidence="11"/>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6412548at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015431">
        <property type="term" value="F:ABC-type glutathione S-conjugate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1098"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1145"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1230"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1328"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1360"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="438"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="805"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="1102"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1427"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="764"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1035"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1048"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7639921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9491270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1666" mass="189220" checksum="B5EC2306F65ED06D" modified="2023-02-22" version="1">MEDRYFCGNDDGSSVTTTTILDLNQLWNSTVPEFSKCSLKTLPFWIPSFFLWIFAPVEVYFLLKKRFASSNRYYSGNRQPITIPYNFYNVSRLFCVILLIIANVAQLFHDLCYYNPFLDLINKQIEIDTDVKLATSADISASLLNIITFSFFACFTQLHRRHGKHTSGVAWIFMIISILSFLPIIYTFILFGFSNENVYLQIGLVNQNNRTILSAIFLIHTIMLIIIFLQTCFADQKPTTLLLQTQTSINDDDYTLNNSVNSMQRSKILNNVDSFEMNSPYEPNGTIIEETISSSASCDQSLLGTAKKSHQPIECPQLRSSFLSQITFWWFNTMAITGFRRSLTMDDLWQLRPKDQTNNVAPKFDRHWRSQSHQSQTQLMKKQYQQQQQQQQQQQQSSSSIPDTPIVVTATATDVIKPKTANIVWAICKTFGWLFISGAMFKLGHDLLQFVAPQLLKLFIAFVKKPSTEEPIWHGYFIAVLFFLTATVQSFMLNYYFYIMFLIGMRLRTSLISAIYRKALTLSNASRKQTTTGEIVNLMSVDAQRFVDVLPFLNLIWSSPLQIALTVYFLWMELGPSVLAGLGVMVLMIPINGFISSYQRRLQMKQMKKKDERVKVINELLNGIRVIKLYAWEVPFIRKVSTIRNSEIDYLKKIGYLHSVTSFLWTCAPFMVSFVTFTIYVLSSKDNILDPQKAFVSLSLFNLLRFPLSMLPMLISMLVSCSVSITRLNRFLHAPQLENYVKRNEELMDNLDIRIENGTFCWENEKTDDNDDEKKNKKKKNKSNDDEDDDEQTKTNGDANQEPLLSMNDENIPKQTTLTLKSINMEIQKGSLVAIVGNVGSGKSSLISAILGEMNCINGRVQINHNSSVAYVTQQAWIQNATLRDNILFGKPFVESRYNSIVDMCALKPDISILPGGDQTEIGEKGINLSGGQKQRVAIARACYAHSDIILMDDPLSAVDSHVAKHIFARVISNRTGYLKNRTRILVTNNISLLPDFDQIIVLNHGAISEIGTYSQLMASSGKFSEFVREFASNEKQESADSDSTAGELHRTSSLSKDEPITPAKKSDNNKLIESERTETGEVKLSVYITYFRSLTCLWVTIILVGFIGMQAASVFSNVWLAIWSNDQISANITDAEIQLRNRRLTVYGGFGFIQASCVLIGAIAFANGVVQSSRTLHRLLMERIMRSPIQFFDTTPLGRIVNRFSKDIDTIDSTIPHTMRGWLSCFLQVLSTFILIIIEINIFLLVAIPLFLFYYLIQKFYVATSRQLKRLESVTRSPIYSHFGETLSGVSTIRAYGCSKRFIQESNERVDTNQRCYFPSFIANRWLAVRLEFCGNMITFFAAAFSVLSRDTFQSQPGFAGLIMTYAMSITQTLNWLIRMTSEMETNVVSVERIDEYCQIPTEREWTRQSNVGPAIPAKWPEDGEINFDEFCIRYRDGLKLVLNNITIKVESGEKIGIVGRTGAGKSTLTLALFRLLECSSGKIVIDNIDISLIGLHELRSKLSIIPQDPVLFSGTIRSNLDPFNIQSDEQLWRALEHSHLKQYVSGLESGLDYTVAENGENLSVGQRQLICLARALLRKTKILILDEATAAIDLETDSLIQQTIRKEFADCTILTIAHRLNTIIDSNRVLVLDKGRVVEYDSPQKLLANRQSRFYALAKDARLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HL94</accession>
    <name>A0A922HL94_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger, matrin-type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ZMAT2</name>
        <name evidence="7" type="ORF">DERF_014064</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HL94"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002461">
        <property type="entry name" value="Zinc finger matrin-type protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="6">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9493305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="229" mass="26990" checksum="59CC58BBF127C728" modified="2023-02-22" version="1">MNNSAGNDFRRRWDRDEYERKAQERLQKNKRKNPDDDKNDDQKNLDNEIDGDDDDDDDKQSEQIAAKKRENLKARSFKVDLESKLGKTVVISKATPSSQAGGYHCPVCDCVVKDSINYLDHINGKKHQKNLGMNMRISRSTLDDVKERFQMKLKEKMEKKNEYDIEEKMKELREEEEKLKAYRKQKRKEKRQQQQEQQQKKKSDGDDDDHDEMASMMGFASFGSTSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMN6</accession>
    <name>A0A922HMN6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_016704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000010">
        <property type="protein sequence ID" value="KAH9490505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMN6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45237">
        <property type="entry name" value="POSSIBLE PARA-NITROBENZYL ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45237:SF2">
        <property type="entry name" value="POSSIBLE PARA-NITROBENZYL ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037886602" description="Carboxylesterase type B domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="3">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9490505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="107" mass="12232" checksum="AAEAC9D740E1F534" modified="2023-02-22" version="1">MNRFAFIFALILNICFISSFGAGEEYAPIVDIRHGKIRGIVRTIGDKKVYLYQGFRFGEAKRFEKPTMVTSWPGDIYNATKVGNSCVQFMNQFVLENVTNESEDCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNC8</accession>
    <name>A0A922HNC8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">guanylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NPR2_3</name>
        <name evidence="18" type="ORF">DERF_014682</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNC8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="584"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="17">
        <location>
            <begin position="927"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1141"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1156"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9493958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1166" mass="132183" checksum="C4A7AF2368A51782" modified="2023-02-22" version="1">MYVSSWYIVVILFILLDLILTTRSVQISQDRRNNDNNNINNSSIILRRRQSNDLPSSSMVIGGDHTAVSINRIDLVLLISNQNELPISYEILKPTLEMAIQDAAKKYPHLQFYLNPVYDDNICQSNVLGALAAEKYYTGHVSAFIGPICSLALDPVSRMASYWNVPVFTAGGISYEFSYKKIFTTLTRISFSLDRVSHFFFKIFQVYGWQHISLIVDETELANKLVRISLQSIFKEAEFGYEIFLESITYERKLPNVTIDYQKMLRQASRSARVIILVTNGENTRDIMIEAHSLGMGGGEYVFFGIELLKTNKESADFSWYKAGDRKNKIAKEMYESLMIMAIRVPVSPEYTSFVHKVTKLSSEEFGRMANHDDVNPVVAAFYDCVFMYAWAYNYTLAKGGDVTDGRSLIRGALWDRTFPDALTGDILINQNGDREVDYTLNDLDPETGTMRPVATYFGARRIFDKFAGVEIHWPKEYGPAPDVPDCGFTGDAPHCIKHEGFPIWASILITFFVVILLTLIISFFAYKKIKMEQDLNDNWWRVVYEDIIFPNQAKSGAKSALSLASDNDGYQSGKASSLRIGSIGHSLLSAAGELDTVHVGIYKGLKIAFKPLQIKKLAMSRQLLVEIKQMRDLTHENLTRFIGICPDEPNYGVVNELMIRGSLHDLLETEKIQIDWTFKYSMMTDIVEGMLFLQNSTLEYHGHLKSTNCVVDGRFMVKITDYGLRTLHAQITREHDLNSKALFWTAPEHLRSKDPLNSGSKKGDIYAFAIILQEIITRSPPFESLERLGRKKKTYQPDEILDRVRMGTVPPFRPEVAPDEASKELLTLMQECWDEHPNNRPDFIVIKQKLRRITRGISSRNFLDNLLNRMEQYSQNLERIVEEKTQSVIEEKQKTEELLYQLLPRFIAEELKRGSHVKPESFESVTIFFSDIVGFTLLSAESSPLQVVDLLNDLYTCFDAIIDIHDVYKVETIGDAYMVASGLPIRNGNDHAKEIAMLALNLKKAVSGFKIRHSPKKRLQIRIGIHSGPCVAGVVGLKMPKYCLFGEPQRIHISENTKKLLDTFGCFTIIPRGEVEVKGKGVMVTYWLESGRRAGGVGGVGSIGSQQTSSIGNQSSFNELEKDVPIQDEFRQSAKHRTEYSSFNDHNNNNTNTNIPISESIANIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNI3</accession>
    <name>A0A922HNI3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_015052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNI3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="69" mass="8174" checksum="3F665ACCBA536705" modified="2023-02-22" version="1">MFRTFEVSTLIDKKTYIFQIKTKQVTGNEEQNGKWKHMRKALRLSISEITLLLPLKKSCQALMLYNCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNW4</accession>
    <name>A0A922HNW4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNW4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="400" mass="42546" checksum="E00D759B50FAFECB" modified="2023-02-22" version="1">MIPSISESDESGEAMPDGGWKQPESSKPKPSVSVPVSWSKESGGGPKSSKGPTFSMEESSDELEESSIELQKLKTSPPRTDVAKSIGQKEKGPGILSSSDFSKSKESSSSSASDESYEEESEESSKERPSSGGGGGGFSFGPAKKSPSSSTVSSSGGGKEKKQKDSEKPSILKVLSSAVDHIKKLGDHKQSSTPSSIPKFSKTVDDDDDEDNVVDINRPKIVKSKFPRSPNENETTTSSSSVNPIIIDIVNDEDSKPEKGKKQVIVTKPESSDESVDEEKGKASSPLQPSPTPPPPPPTTTPPSPPPKQQQPSSSSLSPSSGEGGETGNEINNNNNNDKQPPPQSTTENDKGKEESTDKDKSHNDDGGGNGEKLEKLLKSSIMVLRQLNRTKNFLHQWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTF7</accession>
    <name>A0A922HTF7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTF7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="7311" checksum="3D2125D7491319C9" modified="2023-02-22" version="1">MGNIYEIIRKKNSRNKVKFLGPTFYESNKPIMNDRWNCLNVRFISIVIGYHIRLALSWHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTN4</accession>
    <name>A0A922HTN4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTN4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="7404" checksum="636EE4D0045D0D34" modified="2023-02-22" version="1">MVRIMILNTHYKKKFDDDDQMIPKDFDFDLQVQIKPKGTYEKRKKSFDNQMISNDYGDQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU06</accession>
    <name>A0A922HU06_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_009453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU06"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000085">
        <property type="entry name" value="Histone H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="8">
        <location>
            <begin position="72"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9510965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="167" mass="19632" checksum="0770BAE3BB8C3524" modified="2023-02-22" version="1">MPRIKQSPKKSENIHFTINVEISRNKSRKNKKKIKSPNKTCKKYVKVKNQNDKQSISSKASSSILKRKRYRPGTVALREIRQYQQFGQLLIPKMSFQRLVHNITKRMYANHNYRMQESAIMALQEASESYLTGLFEDTNLLAHHANRVTIMTKDMRLALRIRGDRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUA1</accession>
    <name>A0A922HUA1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUA1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="129" mass="15758" checksum="EDFAF86D5B486613" modified="2023-02-22" version="1">MCITRKKSYHYQHNHCHIDQIDNRPLVDFDTSEFCEFESNHIKFVYMEKKDYGSIFCLHHHHLHHLSSNKHVDYRFPFFSYSLLFHTHIDPTLQKHDEQQQQKNFNAKKKLSPRITHSKKNVYHFMTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUD3</accession>
    <name>A0A922HUD3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol-glycan biosynthesis class W protein</fullName>
            <ecNumber evidence="5">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_009646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUD3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9511175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="462" mass="53067" checksum="88B352AB966CC2F4" modified="2023-02-22" version="1">MNAELKHRREQFIHGNHGSNGPWEIFQLIIIAQFSHILYESFIFAFPNLRKTWPILLFIIDFLMIYSPFIMAVTVWHDHIVLLLTTISVLILFNFSIYVMYNSKRICWRNIGQQSIQYPDSKRFPYISNMMSSLLLATCLAIFAVDFRSFDRRFSKTEMYGWSLMDVGVGCFIAINGALSPESRLINSNVSLIARFMKTLRSSLPLLVIGFIRLAAVKSVNYQEHVTEYGVHWNFFFTISFVKILSSILCAFLGSRINLCAVSIMVMIVQQMMLKIFGTEFIMDSSNRTLNVFTANKEGLMSLPGFISIYLFFVQLGRNYIPKREKVSELLSISMQIVIIGLQSLAIMFAAHHLLEPVSRREANMSFICFIICCACLNILIELVYFLWIQIAKPNFSDYESLVFTVINRKGLLIFLIANLITGLVNLTIDTMAMNNVMSVLLIHLYGVILTFSGFILDKIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVK3</accession>
    <name>A0A922HVK3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVK3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="7584" checksum="ACD53C7E4099A1D6" modified="2023-02-22" version="1">MLLHHVNYSLKLKLRISVTTGIGLGFIGFIGDGSGGGRLELFGAYNKQECFFRALVCIRRAGLFLVAPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVL6</accession>
    <name>A0A922HVL6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVL6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7971" checksum="2FA552331CDD4A46" modified="2023-02-22" version="1">MNPGIYLNVFKSNYYYYFRQHQILFKKLLTTIMYECEYFNNESCIHDDYDDDSIKLKSFTSSRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVQ8</accession>
    <name>A0A922HVQ8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVQ8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
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        <location>
            <begin position="607"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="778" mass="84517" checksum="1D139837C9C66BD0" modified="2023-02-22" version="1">MIDIDRVTNTTTSTIISSSTTDNNHNNFLSYHLHDNNDNHNLIGINNQYDNQDHQQQQPYSIYHHHQHQQQQQQEQHFIVDNDEHLEYLHQQQQEQLNQNAHLNQKSITLYSSSSLYPLSSSGSSNNSSSFQSYFLSQLVDCNDNQPQPQQQQQQESHQLNHHYDQQQQQQQLSANIISGSGANHNQSNKTHHLNSTGGYSSSSSDNSTNSSSSSLSLSSLSSNSSSQEQNQEQNNDNKEIDTGSNLITSNSHHNSYKDLSLQHDHYNQLHNHNGQQLNSNHLQYEADLNDTAINKSDKILINHQSIQNPFHHHNHSQFVYQHLNRNNGEIEQNYDSNVITSGDQNYHSHYQQQQRQQQHDVSFITKSKVEKDEEKKDQDKDFNIANHLRIAAKGQQSTTRTMFQNLMSGHYTVGGSGAGGQNHHPNHHHPHHHHHHHAAVAAAAVQHQADLAAAAAAAYHNHPLSSMYAARTQYGTSISTSSPEHNNNDTSANDQQQQQQHQQQQQQSNIDENNGDNNNNNGDGANSSTADVGDEDDRAATTPTSSILLTNGNANRSQSSSSSSSSSATAAVAASAFQNSQHFNNSTTSNDTSPFGSNRFPFQNVSSSSSSCSITASSPSPTGVQTNNPNGSNGGSSNSQQQRQRSNNGDGGGSNNGNGTTSSSSSSSTISDPPTTSSSSTAASLAAAAAANSYASTFRSATMNGLHPAYAAASYEAAAAAAAACAWAGRLEHSVPSSLTGRLTDPHHHHTTTAAAGFPAGLAASQAAAFRRSETQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVT4</accession>
    <name>A0A922HVT4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pre-rRNA processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RRP12_1</name>
        <name evidence="2" type="ORF">DERF_011637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVT4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="134" mass="15350" checksum="475EA3EE48753990" modified="2023-02-22" version="1">MFFQKYRQNYKQQQQQQHNNDSSVDNNSNNNNNLPYGNDNKSTISSKKSTKSKKSSITNHHGGGGDVYRSKKASGDMKRRGLPDPYAYYPLNAMSLNRRKQLKQRGQLKAIVKSAQKGAAKGHHIRNKRRKTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW40</accession>
    <name>A0A922HW40_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Glycine receptor subunit alpha-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">GLRA3_3</name>
        <name evidence="22" type="ORF">DERF_011431</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glutamate-gated chloride channel (TC 1.A.9.4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW40"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008068">
        <property type="term" value="F:extracellularly glutamate-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18993">
        <property type="entry name" value="LGIC_ECD_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19062">
        <property type="entry name" value="LGIC_TM_GluCl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000022">
        <property type="entry name" value="glutamate-gated chloride channel isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044721">
        <property type="entry name" value="GluCl_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10 22" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="183"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="402"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAH9506713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="604" mass="69160" checksum="53C5468FB71B97B7" modified="2023-02-22" version="1">MDNHLAKSANKINNPMQCKLIGNGSENNNKDNDRMKRSKTIIEDNNPIKRPINIDDHDNNFIRQTNAVVDQTSSAIDVIDVYQVKTTWTFSSQSPRYTTTMMMMDSTSLLSSSSPLSSSSSLFRQPSPILSSPSSAIKLPIQLFHQVLSNIYIKLVFLFMMFSYLFICPVHPSANIRAMEKGILDKIIGEGYDSRIRPMGNASVGARGGDGPAMINVNLLIRSISRIDDVVMEYSVQVTFREQWVDSRLKFDNMNGQIRYLVLTDPNKVWRPDLFFKNEKEGHFHDIIMPNVLLRIYPQGGVLYSIRISLVLACPMNLKYYPLDKQICSIQMASYGYTTEDLMFVWKHEDPVQITTNLHLPRFTLEKYLTDYCTSKTNTGSYSCLKVDLLFKREFSYYLIQIYIPCCMLVIVSWVSFWLDPNAIPARVSLGVTTLLTMATSISGINSSLPPVSYTKAIDVWTGVCLTFVFGALLEFALVNYASRSDAHRAALKQQQAALAAQRKWDLEHGTALETEHMDDRNAAFAMRPLVRQHGDYAGEKLRACEIHVMPKRNWCKRWLSKFPTRSKRIDVISRIFFPLMFALFNLVYWTTYLFREDMQDFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW86</accession>
    <name>A0A922HW86_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW86"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037021820" evidence="1">
        <location>
            <begin position="20"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9515829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="115" mass="10734" checksum="1525B3E8B1627073" modified="2023-02-22" version="1">MKSIFIIVFFAVFAIAVSAMRYGGGGGGGGYGKGGGGGGYSRMSYGGGGGGGYGKGGGGGGYSRMSYGGGGGGYGKGGGGGGYGRGGGGGGGGGKILWLNHKSFIIVIISFNSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWL0</accession>
    <name>A0A922HWL0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWL0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="107" mass="12161" checksum="D5EFFC466088C23E" modified="2023-02-22" version="1">MLGHNEDDEQEPIDAAVVLQPPQLDEQIDVLFNKKFITNSRWPFIREKLKKLTPLTIGTNNFLTSSIARSILAMARFSVSSTVINTCNLSFKCSQFGLPRFCSSYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWM8</accession>
    <name>A0A922HWM8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Spectrin beta chain, non-erythrocytic 5</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="18">Spectrin beta chain-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SPTBN5_1</name>
        <name evidence="19" type="ORF">DERF_006803</name>
        <name evidence="18" type="ORF">HUG17_1355</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spectrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9942256at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051693">
        <property type="term" value="P:actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21193">
        <property type="entry name" value="CH_beta_spectrin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10571">
        <property type="entry name" value="PH_beta_spectrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000001">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000007">
        <property type="entry name" value="Spectrin alpha chain non-erythrocytic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000024">
        <property type="entry name" value="Spectrin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000043">
        <property type="entry name" value="Spectrin beta chain, non-erythrocytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001605">
        <property type="entry name" value="PH_dom-spectrin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00683">
        <property type="entry name" value="SPECTRINPH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0117">Actin capping</keyword>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="17">
        <location>
            <begin position="39"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="17">
        <location>
            <begin position="158"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="842"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="16">
        <location>
            <begin position="3701"/>
            <end position="3808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1572"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3820"/>
            <end position="3908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3926"/>
            <end position="3961"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="619"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1414"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1981"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2557"/>
            <end position="2584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2660"/>
            <end position="2687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="2948"/>
            <end position="2982"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3035"/>
            <end position="3074"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3281"/>
            <end position="3311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3368"/>
            <end position="3420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="3618"/>
            <end position="3645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1584"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="3820"/>
            <end position="3832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="3835"/>
            <end position="3848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="3857"/>
            <end position="3869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="3950"/>
            <end position="3961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7645817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9516039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="3961" mass="466163" checksum="68FE0427AC5891A4" modified="2023-02-22" version="1">MMKNNKSNNHKHYHHSNNDNGSIKFERNRINQLHEERIRVQKKTFTKWMNSFLQKAKMEIDDIFVDLADGKKLLKLLEIISGEKLGKPNNGKLRVQKIENVNKCLAFLHTKVKLESIGAEDIVDGNKTLILGLLWTIILRFQIQDIEIQLEEDTDKKHSAKEALLLWCQRKTNGYPHAYVTDFTQSWRNGMAFNALIHSHRPELINFEKLDPKNSIENLNNAFKVAQENLAIQPLLDPEDVDTAKPDEKSILTYVSSYYHTFAKYNSELISGKRITNIISQLMEIDRLQLNYELLTTNLLNWIQMKIHQLDKREFFNNLDQIQHEFSKFKEYRTVEKPPKYRERSEIEALLFNIQTKRKALGQVLYVPPEGKLSQDIHKSWMDLEKGEHRNELKLREEMRRLGKINNMAESFYRKSDIRKSYLDEMIQVLSDVRYGNNLSQVEATIKKHEAISADILSRKERIDSLAQMVVELKKENYFLIDKVENFFREIKLSWDKLISVLEMHQKNLSVASNFMRTKLEIETIDNEFHDIIKRISIDSNVTHLRTAEEYLQTHMLLEAQIASNDETVKRLTNNAIKLLEQEQVQRSVLLQKEIPNLKQSLHSLQKSHETLNHQSTMKRQKLIKLRDFYRLLQDLEEEEATLAEKLNICQAILPGKDLLGIISLQQKHNVFEAEIKTHEGRIKIIEKKAQNFMENDSTENKLIQDKLEALHEIWKQLQEISAHKSKELAIIIEAFQYHADANETESWLKEKMQLARSEDYGKDEQSAQALLQRHNFLESEVTAYSHEVERLNSQSEKMIDSDVESLFLLGAQSYSVDDPVDEQLTEETINDEADMIREVCEEIPQVYVLYDFKDKNCHVKKGDVLLLIAKSTPEWWKVCRDGVPNEFYVPSNYVKEIEPKTITKFLEKPLQQPRKLSAIVKRRHSKRRLSIVYGADTVEQRKLLINTNYKRLVELCRIRRKSLEDSVKMFGFNSECDAFENWLNDMENTIQKSMNLNKEQQNYTTPATDLGKQFDKMITDLLANRARLDEINKMANEMNSSMYMSAVKKRKEQIQKKWDQVNFLQKQLGKNIEGLTSVEVFDAACTETLERINDKLEKVNDHSFDIGQDLKTAQALQRRHENLERELIPITDSLKKLNIISDNVKSSYPLEKSRVDKRLVELKQLWERLKKCSDEKRCWLDKMIGLQIVRNSTNDINAWLTSYAKPLLQYDPNDPSFKNVESLEAITKEHNDLLVDIKGKSNDIEDLRNLAQKLKSQIDPNEFIIVDEMSQKYEQVHEEWNKKTNFLQQCFDVNTFNQEADRIDTIINSDLTFLEFDDVGNSCQDIDALIKRHERFVDTLNAQDQRIYNFIDFGDKLIQNNHFDAEIIKERQKKINERRKTLKDKAFLRQKVLKDAKVYHEIKSDAEEFSNWCQSKRNQVKDLFDGKENLRNEVTIERKLKKHQTLTAEVRAHRIQMQKILNDLTDLNRNSHLISTEELDEIERKVKDEWIDLNNLIEDNEKLMSHISGKMERKKSLQTMQNRIDEIQIEINSDETPIDRRTCKKLLQKNKLIEKELATLENKVYNTKTDRSTDAIDSGNTDDGNDNQQEDDHDYKELKSKIINLKKPLNKRNQHLLQLNEYFQFEFDANAQIQWIKDRIILVSSTDVPQNLTDAQNWLKKIEQNLKNEVHAHEIHVNSILAKADEFIADNHIENEKIKAISEELGSNWKQLLDLMDARIEKLKVYLKMHQFLSDCNEIESWLNDKINILNNPIYGNDEVTLIKLLQKQKSIDLEIDTYAGLIDELLRQSEDLSSTVKNEHEQKLLKTRAQDSNVQLKKIQKLANERNLNLIDLKQFYEYCQESNDFLEWLQKKQQILSNEDYGKDYEHCIILQAKFFDLKRLICANEERYKQCMENAKRFKRNDDHHFTTNSETITATWQEVMNLLQAKEQKFIAAVKIHRFNRDVADAYERIHGKHAILNNQDYGRDCQSTQNLIRNHDVFENDLVALEAQLQILINDSVKLKAAYPGGNAKQITEKLKSVLDYWEKLKDSSLFRRQKLCDTYEFYRFVSIVRNLEQWASNLINEMKINDDQISNELNKNDNIIHVDKAQNAKNIHERIKSEIDAREEEFNILVQDANKLTKNPFYSQIKEHTEKLLATRDQLYNTWQVKDAALDQLLDYCIFSRDAKQLEQLCQQFKNRLETTEEGQTVEEVDRNLKKFDEFVKLFESHEQKFNGLKECKTKLIEKNNNHSDKIKIRFEDLLAKKTKLWQIILSKRDQLSDDLIFAQFTRDVIETDSWIDEKRIQIEQISLRDKNNDDIETKLKKLQKHQALEAEINANTSRMTVIKSKEKHLISKNHPNSIQIRSQFDNLLKKWEELRTLSKDIFAGFEEAKDIYEFNKNVGLVESWIREKELMIQFNDTGEDYEHCTALLKKLDDVGTGLKVDEDEIHQINHLADKLVNQCKNENQVDEKRLALNEKWKQLQQKIANYRQRLIDALEIHSLNRDLDEVNERVIEKQLLASKECDAKNLSSAENEQRKHISLCYDIYGIDNHFKNINDNDVRRLIGKNPELMEKSRTKIENIQDNLRKLSQECSTKDEKLKFIVKLHKFFDLIKEYENWANIILTNKLFNTFTPENISQTESELQDHGYIKDELVAKKQNNKNLKEYGLNLLHELKQDERENQSHIQKIQECIEKNDELRRKLDQAWEDKSNYLKQCKQLLKFNDLYKQSDSWLTLKEAFLTNEDLGSNLTTVEDLLKKHDSFVQSFAGQQRIIDLSTFAQELMEQKHFDLHNIQMKHSEILERRDKLFESAKIRKCKLEDSKLYFNFLRSYNEIHGWLTEKIKVANDESYLDSINLLSKKQKHAAFEAEINSNKGRIEELINEGENLINNSHFCSEEIKSNLDTIKKLYRQLDESASFKRNRLNEAYQALQFFRLCDVLLLWIKDIEAILNDPDNGKDLSSVRNLLKKHQLLENDVHNHNENIENIKDQMAHFEQSNHFQIDEIEEKGNQVIKCFNEIQKPINRRRETLEEYLTFFQFKNDVEHEFFWIKEKENQLNQFDNANSVLDIQRLIKRHKMLESEIQTREIQLSALVSKGHSLLKAESSNFEEVKYLTNELQKNIQYIKDALALKRIHLIDSLESHQFYSDITEAESWINEKFSFLLNDDNGRDEESVSMLLKRLEAISSESERFNSTLMTKLIQQSKQLIDKNHSESNEIQQKLDGLVDKFDQLSQGILKKRQTLSERSLYFLFEREADELISWIKDQQIIAKSEDYGQDVEHVESLIQQFNTFISFIMSNQERIKSLEKQAENVTNSEEKLNEIQSLWTQLKEIAARRQELLQSAEEVHRFDQSVDETIYWIREKKSSTIFDEVNSKYDDINTIKAKIHQLEGFERDLNAVREQVETLFIEADKLIDSFENVKDQIQERKTEVKEVWDDLNMKTKLQKATLIQIENIQSYFDHYKELLTWINEIQALITADDKLVSDVLAAEQQLSRHREYETEIKSKNESVQEFLVTGEKIISRGHIMSKEIEQCNERIKNAYDNLLRTWEKRFTLYGYNLDARQFVRDVEQMEKWIKASHNYIDDNNFGDSIGEVEDLLLKHEEFEKTISAQMEKLNKIEKITLMEKYFEALKREEEEQRTAELLRQEKEKRMEEEQKRILFRRSNEESKYYENEANKSKSMSSKHSSKTPRRYASFSFVRKSTKIQPLTPNLPQFSCKGFLERKHLSEPGGKKAESRTWKTYYTVLCGHLLCFFKDKNAFNKNSAASAPLSILNAKCEKTEYKHKKHVFSIELTNMSKYLFITTDGDRLKEWISAIAFRASLTPSDQLIIPSSSSTDLGSSQNGAHVSDSSSSSHKSSLSSLPDIHHLNNDNSPQSVNQVEIKSTDNNNQNDLNDETNSSDDKKSYFPSPEASRPKISKYGSLPVNMVPIKEDSIYAKDEDHSTGLPTMKSFDGDIGLNNEKTKKRRSFFKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXJ5</accession>
    <name>A0A922HXJ5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KIF5B</name>
        <name evidence="14" type="ORF">DERF_006657</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Oligomer composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXJ5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098957">
        <property type="term" value="P:anterograde axonal transport of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007292">
        <property type="term" value="P:female gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000067">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="8"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="431"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="642"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="850"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="87"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9515883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1177" mass="133702" checksum="5A0C74876923BFF4" modified="2023-02-22" version="1">MSDGSECNIKVVCRFRPLNDSEEKSGSKFVVKFPSNSEEGLTISGKTYVFDKVFKPNASQEKVYNEAAKAIVKDVLGGYNGTIFAYGQTSSGKTHTMEGVLNDPDYMGIIPRIVNDIFNYIYSIDEAIEFHIKVSYFEIYLDKIRDLLDVSKVNLSVHEDKNRCTFVKGATERFVTCPEEVMEVIDEGKSNRHIAVTNMNEHSSRSHSVFLINVKQENQDNQKKLTGKLYLVDLAGSEKVSKTGAEGMVLDEAKNINKSLSALGNVISALADGNKSHIPYRDSKLTRILQESLGGNSRTTIIICCSPASFNEMETKSTLEFGRRAKTIKNVVIVNEELTAEEWKRRYEREREKVTKLRAQLQRCEQELTRWRNGESVPPDEQSGLVRDLDTSTLSLSESVHNLPAASAPAMNINVPMFAATTNEPLTNEERMKFEEERARLYAQLDEKDDEIDKYSQQIEKLKEQIVEQEEIFTSSRRDNDVLQADITRFQQENESLKEEVKEVLQALEELAVNYDQKSQEFETKNREFETLSEELTQKSSLLNGQESELQQIKEQMNHQKRRYVEMVTNLMKDLSEVGIVLGSNQNASFIGELKISNDASKLDDEFTVARLFISKMKSEVKALTTRTAHLETYQSSCNKKIESYEKELQERRLLISQYEAKMNSLQETIKEADKKLRVLEETVDQLNEECAKLKAAEEMHQVTSKEKEKEKDSVEQMKNALEQQIEKHRENHQKQLATLRDEIAERQSMVDQYKDLNQKMTLALERLQQDYDKLKAEENDKSAKLHEMTLLNEKCEQAKQDLKGLEETVAKELNSLFNLRKLFVEDIKNRFKKISIGEEQDDSSNSGGSLAQKQKIAFLENNLEQLTKVHKQLVRDNAELRCELPKLEKRLRTTMERVKTLEAALKEAKESAMKDRKRYQHEVDRIKEAVRQKNLARRGHVAQIVKPIRAGGGPNTVVYRPNNMQSNPRTGASRLSWSGPAGLILDGQYNWIPAGVAAAPPPCLLDTRRCGGCAAPPAWYPAKGVNFNASCLTVGFYARRVASGLRFGTAGSAITCALHLIPLKKLRTPNSIIIIANQKVEEIQYFCGKKPHKSFHVAILVAKANTTGNRPRTNLNGSLRSRSFCCKMNHSLLVNIRASMLRLFTNKRVPLSKPLCGSILRLNMIIDPMFNPSLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXM2</accession>
    <name>A0A922HXM2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_010056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXM2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000736">
        <property type="entry name" value="Zinc finger protein 423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="571"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="918"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1049"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1107"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="922"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1003"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1116"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9511608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1168" mass="130566" checksum="1DFA74FA56FCA57E" modified="2023-02-22" version="1">MGLINMEETPFQCEYCHRFFKHKRSRDRHVKLHTGDKRFQCSQCESAFSRSDHLKIHMKTHDHMKPFQCSFCNRGYNTAAALSSHMQNHKRNVSSSSSAAAAASAMEHHGSHLSSQNNHHQSNKSIRSYNMMPLKTINGTQTSSSNAAAAAATAAIISNGHHHINGIAGNGSIDSSSSSSSSLSSIDSNQNRYPSNQQQQQQQQSPLKRPLIDEIHRQQQFINKDLLLSNNKKLKNNLHGSWTSSSSLSPNDGIPHHHPHHNHQTSSPLKNSNLLINDLNSHQHHLSNDNASSSLFGGPNSGNEFIVSQKETSSGLLLPQPPSQQENGRTEIDSPYNPFLWQSLRMANFAQQQHQHQQQQQQSGLFPSSTLNTPHQYNNFLSKFPFYSLYDHLAAAYTNGHAAAAAAAATQSYQHLLKTYQQQQQNPNSASTTTTFPSSWSSSPSSSSTFAAMANHTTPYHTNQQTNSICQAMLDNLANERATAAAAAAAAASMIVMEKFHCPYCAEQQQQQQTQSATVTFDNLEKFHDHIITHVCKKQIKFTCDQCKNIHFEQRKQLDEHLMDKHCARVYQCQLCQQLFDTKQLIQKHFETFSHYSEDLQLFCILCDKHFDIENDFYQHVKQKHNNTMNLMKKLDELFVQQNGSTNNNNNIQQPLTPSSSSSSSSSSSSSASASASISKSTTPNTASVAEAATQQFHNTNANVSVINDEQSQSIIKIQSTTPPSSLSTSICSGNNEHFIDSQPKLKLKMKPTTIVSTAKSNGQKRLSNFGIDNLIKKDHQPSSSPPPPPSQHQQQLQKSLLKISNLKLETTTANADNLDDCKESTFIQCNICDQRILRDQLIDHQHHHHHSAITISSSLQQQQCIECNLILLTANEFIKHQKSHSSNDNDDDDDDGDGQKQCCCICKKIFTNIQEHDQKSSKTALATESLSSSSPAPTSPSSIMSTGTSRSSSSSSSLASSIAKQQQQQQKQQQKHSSSHPKQLSPKIADEPPESNNNLDHHHSHHHQNNTRFDNHHHHHHHHHHHHHQAYCIDESISDVDEEDIANEINDDDDDENNIKEEEEENINDNDDENENVEIELPIINNDDHDDHDHQINKCSKTIINGHRNHHRNNNQRSIKINNDNNNISNTNGSSGNSNKKSSKTTTATTAKTKQSISVPQPVECRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYE5</accession>
    <name>A0A922HYE5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FAM46A</name>
        <name evidence="5" type="ORF">DERF_010354</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:11333"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TENT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYE5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012937">
        <property type="entry name" value="TET5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974:SF36">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12974">
        <property type="entry name" value="PRION-LIKE- Q/N-RICH -DOMAIN-BEARING PROTEIN PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07984">
        <property type="entry name" value="NTP_transf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01153">
        <property type="entry name" value="DUF1693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9511931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="708" mass="83061" checksum="748DE0C3C9766086" modified="2023-02-22" version="1">MDSMKDSDAIAEDESCSLQIIPFENDCESTDRQLISINHQTFDLRDKRFGILNPRQTKRLKKILKKEMSLIVDFDSETSFDKKITNYCAYPLHIFLQIIGQRLTENNITYRDIRLNGGAASYVLNNRNKTIYNDIDIIFNVNLQNESYFESIRKSIFKLLLDICAPNILEPDIRLIREQVLTKMVKISDNDTRWSLFSIKNFKGCTIEIKFVDKIRRQYEFSVDSFQIILDNVLDDPCIADTIICESVFGDYHEAIYHLNNKFIVTNSPEKIRGGGLFKYCFLLVRDFKPLCHETMKKLEPYMVSRFFIDFTYFECQRDKLCNYLLTHFGNDTMSKYHFLTIFCSVLKRSLKKNFNQKKIIKKYMEITTICFCTLLREFIDNHQFFDQHLTNEKPVNGYDSVNQCLNKELVVSNQTTRPILVTFVFDNIQPNISKLKRQQNLINFIKCHDNIYPKFGGYSFALLPAKIFHSINANNLHSKHEHLNHYIISYSTLYKMDHMFYKLNNENIYQHEIECNSNLFIDQCSSFNSIQNFIYEYQSNEILTKRLPDSLFPVDFSYSNITIDKFSQIPFSPPKNYRLCILNKTPIIYNESIESGIMNKSMIVNNIIKSLSSSSSSSSQHSSCGSNVILHYDHSEETKISSYQKRPLLSINSWQQSITIPCDAINSSYPYQNVWNEYQIYSSPLSNQQQLISNTLYEPSSYYAYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYP3</accession>
    <name>A0A922HYP3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LIM and SH3 domain protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LASP1</name>
        <name evidence="11" type="ORF">DERF_010503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYP3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09447">
        <property type="entry name" value="LIM_LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11789">
        <property type="entry name" value="SH3_Nebulin_family_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000087">
        <property type="entry name" value="LIM zinc-binding domain-containing Nebulette"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000007">
        <property type="entry name" value="nebulin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051759">
        <property type="entry name" value="LIM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000900">
        <property type="entry name" value="Nebulin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218">
        <property type="entry name" value="LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46218:SF4">
        <property type="entry name" value="LIM AND SH3 DOMAIN PROTEIN LASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00880">
        <property type="entry name" value="Nebulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00227">
        <property type="entry name" value="NEBU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51216">
        <property type="entry name" value="NEBULIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="471"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9512096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="530" mass="61377" checksum="4C77AE13A3147E79" modified="2023-02-22" version="1">MTNNKTCARCQKTVYPIEELKCLDKIWHKTCFKCHECGMILNMKTYKGFNKLPYCNAHCPQARATTVAETPESKRLAENTKIQSNIKYHEDFEKQKGKLTQVADDPETLRIRNTTKIISNATYHGEYEKKKQMEERRNLLNEHGDGQITYNNNSIINQPTSIYQQQQPHQQQQQQQYSPPISVHHQNNNNNNNHHIHQQQQNIQNNNLPHHHIQQHHPIVSSSNVTHNNNNKNIPPQQQQQQYVRTPLANPSIQMENHMIQQKNQSHINNNNNHHHHHQQQQQQQQRNQTMATDLNSNKNYYPTTTASNNNNNNIGNQLQPGKLPIGSTMQQHKQLNQTQSAAGYYQQQQQPISNPMMIHHGPPMHTSGYIHQNYSPIKQPQHHQQSIHPNVQQQQQKMYYHHHQGVAAADHHHHHHHPSQVIYPTAAAAGTTTATSTITNYDNHQQYRHQPQPQQQHPQHQQMPPPTRQNLGLCFRAIYDYTAQDVDEVTFMDGDLIVNCQPIDDGWMTGTVQRTGETGMLPSNYVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYS2</accession>
    <name>A0A922HYS2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYS2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7586" checksum="DE7804CAE7B9C209" modified="2023-02-22" version="1">MDKTDTERYIQRGFNMVNFHHQFHHHHDRMEQIEKNIITGMRIFGIFGSGCENEYWREIFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ63</accession>
    <name>A0A922HZ63_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TMEM19</name>
        <name evidence="8" type="ORF">DERF_007904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ63"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9517221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="363" mass="40054" checksum="A57F8D68E482E151" modified="2023-02-22" version="1">MSFTLNGHIYLPLAVASLNCILFFIAIISLFLRDANHQPDWLRCVLAILIPGLMAYRGLKRKTIDYSGAVAGIIIGMSMILSSYIGMVALITCYLAASKATRFGEDIKRQFEPNFKNGGQRNWIQVISNLGAANIALLLRLIWFGVGEIRLDFLHSENYWNSWLLLSSLISISAALGDTFSSELGPVFSGPNTEPLLITTLRRVPRGTNGGVTIDGFVAACIGGFIIGLCSYLSIILFIPTTGHWAHTTSHQITWSTPQWPLLHFCLYSGLLGSALDSLMGATLQYTGYDHRRRRIVECEQQIDPFGSTLSSSSCDQSSNLEHITGKDILDNHEVNLLMTIIMATIVPLIIMPLWPFGFGDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZA0</accession>
    <name>A0A922HZA0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">60S acidic ribosomal protein P0</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RPLP0_1</name>
        <name evidence="12" type="ORF">DERF_009491</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P0 forms a pentameric complex by interaction with dimers of P1 and P2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZA0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037988956" description="Large ribosomal subunit protein uL10" evidence="10">
        <location>
            <begin position="18"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="11">
        <location>
            <begin position="131"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9511006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="336" mass="36990" checksum="E1EE5CD6C41CBFE1" modified="2023-02-22" version="1">MNLIWLFVLKSFNPCFTNLTMGREDRSTWKANYFTKLLSLLDEYSKCFIVGVDNVGSKQMQTIRHSLREDAVLLMGKNTMIRKAIRSHIDNNPALEKLLPHIKSNIGFVFTEKDLVDIRDKILDNKVQAPARAGALAPCDVKIPAQNTGLGPEKTSFFQALSIPTKISKGTIEILNEIHLIKKNDKVGASEATLLNMLNISPFTYGLVIRQVYDSGTVFDPEILDITPEDIRMRFLQGVRNVAAVSLSIGYPTLASVPHSIVNGLKNLISVALVTDIDFEAASRAKEYLKDPSKFAAVAAPVAASGDASAPAAAAEKKEEEEEEEEDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZB0</accession>
    <name>A0A922HZB0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PDE7B</name>
        <name evidence="8" type="ORF">DERF_007605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZB0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="7">
        <location>
            <begin position="123"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9516888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="760" mass="87915" checksum="5F3D1B2530E83E61" modified="2023-02-22" version="1">MIPYSTCMRFNQTRRHSLENDNNKFSPCEWTLVQHFGHNTRVESTIINVTSQDDQTLCFTWAIESQNAAQQSILVDNNNALLASSKERSQSDELDRRSVYLLLALRRRKSLQQSIHPETIPLLDPYYYGITQRYLKYSYQWSFNTFSFDVLTSGHSLSSLLLYFFKEYRFIEIFNLDLINVLRCFNYLEKGYHDTNPYHNSVHAADVTQAMHCFLQESKLKQYLTPMEAMCSLLAAVSHDLDHPGVNQQFLIATNSHLTTMHNNLSVLESHHWRFALSCFYESHIFDHFNEKQWKEIKFLLKNLILATDISRQSEFIHQFNNYIKLGNAFSMEKKEHKYFILQIALKCADLGNPCRPWKISQRWSEQICNEFYRQGDFEKLLGLPVTPMCDRNSTTISKTQTDFFKNIVRPLFELWNVFLDSKLTRQLINNLNFNEYMWKNMENVKQSRIKHSHSLISFSDKFEIESTIRCKSYNKLSPLNLSSITLFENTLTKLKASQTVEKSSKPECINGCGTPPSSKEIIMTTTNSEEKVKLNDDVDFDDEEDDFISEFNCGAILSTPALILPNFCYEKPQSGFYRRGSAPGCIDMIRRNELNTAKGTALLLLCNSLKAKNNNNNNNNNIVKRRSSFPNVKIPKGNIHFKTSLQQQPTNISNMTAAMTTRFNTATCINYAKGKSNRNRNNRVFHHQPESCYFGQHHSCRSSLFDISGGNNHGQATVTAANTCHQYLLTTNKQRGGGNQRRRSVPQDIFIRSLNNYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZT2</accession>
    <name>A0A922HZT2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_006678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZT2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039149">
        <property type="entry name" value="ZNF800"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21020">
        <property type="entry name" value="ZINC FINGER PROTEIN 800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21020:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9515903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="674" mass="77380" checksum="01CEC696FE8AC38A" modified="2023-02-22" version="1">MIIYQEKMVKKRSFANKTVSGSSSTPNIKPEDRKTLEDDLNLLDHSVIREPINVGIKNVHQIITCISDGTKEIKDLILNECNIIYECRVCRNLFRSLANFLAHKRLYCKEHCCEKMVLFDQDWFTKKQEKLIEHEADSLDSESASKMSNPLLDENLNINHKVTSNENFVKTTTCDKSTYVDETILKRYIETSGLITTEERIVKKKRIENLVSKLNSTTTAKPIVDSSIEHVITKNTESVKDSFTTEDTDEFKTIVKNNKNGKQIENEFTAFFKTIFAVKIDFICEYCDVGCTYLSSAIRHLMNIHDMSRISAKKFLIDFGKEHGFSMKEEPNDDCCSRKTDETKIEPVIKIENQNDDFEIIETTNCHHLPSGNLNSPNETNNNHNISESNENRTTVKNKRYETRCSIRKKCFYDCNSQSCFFSKHCPKTIINNDKSIQNHVPDKEIDIEINNDHESKSNGMMINDNFQPPLSSSPLSSASNSDPIDPLSISVKKRTQNLCDRIKKKKMRKIKEFIPILNEHNNESKTCDNNESQQETEKLNFKPTSTVISQSLSSSSSSFGDSNSNGFENFHNDNKDISEDSSLSNLQNNNNNSVDSLDFNLRKIHSQNIIRAKIFDDEIEPVVESTHSPLITKLSLRKFDPDHHHHKNPQKESRLKLHLRTTGSKKCYQIVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I085</accession>
    <name>A0A922I085_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">[heparan sulfate]-glucosamine N-sulfotransferase</fullName>
            <ecNumber evidence="5">2.8.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">NDST1_1</name>
        <name evidence="24" type="ORF">DERF_008060</name>
        <name evidence="23" type="ORF">HUG17_2326</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">JKM2019</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; heparan sulfate biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; heparin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfotransferase 1 family. NDST subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.8" evidence="5"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I085"/>
    <dbReference type="OrthoDB" id="8958249at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019213">
        <property type="term" value="F:deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015016">
        <property type="term" value="F:heparan sulfate N-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021930">
        <property type="entry name" value="Heparan_SO4_deacetylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056793">
        <property type="entry name" value="HSNSD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF56">
        <property type="entry name" value="BIFUNCTIONAL HEPARAN SULFATE N-DEACETYLASE_N-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12062">
        <property type="entry name" value="HSNSD-CE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25119">
        <property type="entry name" value="HSNSD_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulfate-N-deacetylase N-terminal" evidence="22">
        <location>
            <begin position="122"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulfate-N-deacetylase N-terminal" evidence="22">
        <location>
            <begin position="331"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan sulphate-N-deacetylase deacetylase" evidence="21">
        <location>
            <begin position="400"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="20">
        <location>
            <begin position="694"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="16">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="842"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="972"/>
            <end position="976"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="956"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF12062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF25119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH7646788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAH9517383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1021" mass="120325" checksum="F002052093ECCE1D" modified="2023-02-22" version="1">MRYKLLPQYQNGNDHDGSFAINGFVINHNPLNVRQKFSLISLFSRISLRRWLIISLLLTIISFFYFNELIPTQFRGWIRLPPKVNFYCFRVRNPSTSVDDYGQLLFSTQFKPSSSNHRLRSDSRILLFVETQYSRLGRQLIEVFESLRFKYKAELSNRPWSTATPFINQDKGKFSVIIFENLHKYFKLNQYNRQLLDDYCREFHVGIIGFLNNNHTANNSSTIITQSLDTNYPVKIKSGYQLKDYQLNPAATNVLHITRSSSISLGPIIGDDWFVFEPPPPPPPRGISNITAHYSNSFIPIAQALINDFFVDTYPGGYRYSTFNRSYVHSLQSKERNNVDYYNNYKEHLMTTVLLDNGSFDGIQRILFGNGFDRSWLHKLLFIDSLHYLSNGKLSLPLKRYIQIDIDDIFVGERGTRMKQADVDALVEFQQRLQLFMPGFRFNVGFSGKYFHRGFDVENQGDDQMIRMARHFRWFCHTYSHSQAHITTNQTAIENELIANQGFARNNNLPVDNDYIVSPHHSGVYPVHEPLYDAWKNVWKVRVTSTEEYPHLRPSYLRHGFIHKGIMVLPRQTCGLYTHTIFIDRYPGGRDKLEKSIFGGDLFYSFIFNQVNVFMTHQSNYANDRLAPYAFESVLKFLQCWTNLELHSLSPIQMAKKYFQIYPEERDPIWMNPCDDRRHYNIWSTKKSCYQFPRFLIIGPQKTGSTALYTFLQQHPSLLTNLPSNRTFEEIQFFNGPNYQKGIDWYLEFFPLSNLMDKFNISTTISNVTPALNNNNMNGTLVHNQRNYFARTPPNYLEESMHYYEKSSTYFDGEQVPVRVHSLLPHARIVMILISPTFRAYSWYQHMRVHNLSVALQFSFYEVVSLNIPDKHLLDKITMKRLRDLRNRCLNPGMYAIHIERWLSFFPQQQITIIDGEELRRNPISVMDHLQTFLKLEPHIDYRQKIRYDHHKGFFCPINPSTNGTKCLGKSKGRQYPKMNRLAWKYLHRYYWHHNLALSKLLNRLRINLPNWLVTELSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0A0</accession>
    <name>A0A922I0A0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ALG11</name>
        <name evidence="17" type="ORF">DERF_006904</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide. Man(5)GlcNAc(2)-PP-dolichol is a substrate for ALG3, the following enzyme in the biosynthetic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="4 14"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0A0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="16">
        <location>
            <begin position="38"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="15">
        <location>
            <begin position="269"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9516143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="462" mass="52842" checksum="55A6F17ADE2DB546" modified="2023-02-22" version="1">MFLFIIVGILMPIYLLKLYVGYKHEQIRTRYAINGNGKVVAFFHPFCNAGGGGERVMWSAIKALHQRYPQHCYIIYSDNYNVQPLTIVRKASQTFQLDLAVEEMKVHFIKLRLCWLLLAKYYPIFTLLGQNIGSFIVGLEAMLRCPPDIYIDTMGASFTYPLFRLVGSAKVATYTHYPMISADMLQVVACNQSTFNNRSIIAQSQLLTKIKLVYYHLLTFCYRMAGNSANVVMVNSTWTRNHIEALWRRTVVVVYPPCNVDNLSCLSLTNKKANMIISLSQFRPEKNHQLQLKSISRLIDILRENGSTERPLLVMIGSCRNEQDEKLAQSLSQQSIKLGIEDCVQFKLNIHYDEMARLIEEASMAIHTMTNEHFGISVVEFLAAGLLTVAHNSGGPKLDIITENETGFLAENCDQFAHHLYRIMQLSADNKHMIRLKARKSLEQFSQQIFEQSFCQHMSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0A7</accession>
    <name>A0A922I0A7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin- transmembrane protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMX2</name>
        <name evidence="3" type="ORF">DERF_006918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0A7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="110"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9516158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="270" mass="31162" checksum="6205844C6E9A4400" modified="2023-02-22" version="1">MAIINTRDLHKVCHPHYLVNILLAFSFLVLKLVPPFCNYLFKECQLEHRDTEILFFTIVIIMFRTRKQGNVTFLPYLSSACMLMKLGNILLYFNAGPLYGIVFGCCCLLQMLLLPEPTYQGPENIAYMKGEDLEEEIGRDKRVVWLVELYAAWSPPCVDFANVFAELSNKYSLDNLRFAKVDLARNPDTATKYRINISTLSKQLPTVILFMNGHETMRRPLVNEKGKLVNFAFTFDNVVMEYDLDQIYKQCRNNPLTTVAGSMNENKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0B3</accession>
    <name>A0A922I0B3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hexosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_008104</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus</location>
            <location evidence="1 9">Golgi stack membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chondroitin N-acetylgalactosaminyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0B3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047238">
        <property type="term" value="F:glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008428">
        <property type="entry name" value="Chond_GalNAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051227">
        <property type="entry name" value="CS_glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369">
        <property type="entry name" value="CHONDROITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12369:SF13">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05679">
        <property type="entry name" value="CHGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9517428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="901" mass="106341" checksum="7D12DED9575ABF62" modified="2023-02-22" version="1">MMPSYWKPAYYLIRKNKYFFIGCLLGILLSLLFMPMLEDCSKPNSLNGDENDTESIQVLKMNRRDYHLFVRLEKWYREMSRSDYNPMIRNKSVMINEANSHALHMINQPKLAINSMVRDKKLKFFRPRFHSIELNIKMKLLVCVSIRPQLLIQSSSPQSDQYDQLIVQYMNMTNELMLNDFSDNLLYFYPDISTGNMIVSYSGNHRLDVWPQNDNDLPFHVIIMDYLIAKRKLDEYAMILMITERTCLHSFNLQQYLRTLSVSDLVLSTSNDDQSSMTEDSKLKFIATNLGHNDHILNYGLLVSSTLISMCDHDWPCYVKRISRNNNNRHIDGNVHYWHRSFSNTHSFESISSISSFLRDNEQTILDSIFIYPIHFLSTTYQLLQTLITVDSISRLNLKIETIEQRLISITKSTLFNGSFRSRKPRNRYEVNCWLYSNETHMFLPNDVQIIRALNADELKQIRQIKSQCLEWINHHRPQFCIKLQDLSIENLYQKFDAVRGLEYIVDLRVNKCNSLPSESYRFQMLKPLNPIEIVTDIPHASENLRLTMILPVRGHAEVPVAIGFLDHYANVCLKNSNHNTMLIIVLIRTRYISLNDSIDSEFERKEFQRLKKLSLYLQTKFQSNSVRIIFMDINPPDAIYTNDSSSPPRTRFPSEMVYLDLITRSLMATSANEPILLLHCRSNMLFTTQLLNRVRVNTIPDSQIFIPLPFVEYRLRTYKSNQDFEQILRKQSIFQEKFNLSLHQLTMDERSPAGITSSMKFFDVRKDNGYFDDTNQQIVSFYLHDYVRARKQTQTIMPIIRNRQSLVKYQHIYYDTQWDLYQMFVQSNDRIAKDDSRSLIMMKTTEPDLKLYHTSILDDCDHFESNIPNYRSCFHRSLYGLGSKQKLAAIIYEYIRRTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0G9</accession>
    <name>A0A922I0G9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_006596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0G9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9515821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="502" mass="57767" checksum="2BA0A7EEBAFC4F2C" modified="2023-02-22" version="1">MDKLSDRAFKTKIAKTFKSKKFDRKLVSELNEEFENRTAGLDENEYELWIKYDDILKAMINNINLNEQLDNDGDDDVDRNESDADDDDGSDRSSQLDDDDRGLSSESDADTEPEIETELKRIRRKLKKFSMKKKTKRESRSKSDMDNDVPIYKIVNLIKPFKDNVAEWPAFKRRVETLIIGRKDASEDLKRVLISGILKGRASSIWDRCEAKQMNLKKSWKILSKEIEDPDLINLYIQSMILKMTNVKDKYDTDGLEKIESQIEECANAVASLGPRYIDNTSEIVWKIANKFWREESEKIITECRSLDSLLKRARKAYRNAVALAQHNAEHKLPAKSVKNVDPKPRVSSIRTVVANPVKKCFLCDKPGHMATACNSELSSLDKKKIVHDKNLCRICLWPGHKSTDCRRKDVIKCATCKGNHPLSLHEFANAVASLGPRYIDNTSEIVWKIANKFWKKESEKIIAECRSLDDLVERVQKAHRHRILNCKSLAHNVLFVSPHIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0N8</accession>
    <name>A0A922I0N8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA pseudouridine 55 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PUS10</name>
        <name evidence="11" type="ORF">DERF_006685</name>
        <name evidence="10" type="ORF">HUG17_1263</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0N8"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2510:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048742">
        <property type="entry name" value="Pus10_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21237">
        <property type="entry name" value="Pus10_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10 N-terminal eukaryotes" evidence="8">
        <location>
            <begin position="76"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="9">
        <location>
            <begin position="244"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00083669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7645725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9515911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="500" mass="58213" checksum="CA8DEA8ED247542C" modified="2023-02-22" version="1">MSSILNQELIEKIIKLCSIKSLYICFTCILRYSNFRHIFKVNDHNDLWSYCQNHLSNEILLNILKKIFTNDENKLCQSCLDLLNVEYMMIKVKEIADHVSTMFSIDEFQLHIYQPFIITLRHLYFSKLFELNPEDVITVKDVIKTFIIIPIEKAIQAQHSTKGNHVIVLNFDHHQSKIECESLMETCHRNVSSPKRFKSSSTINHAALFRLFETSNNRILELFELIPIKTICTLDVSVCREPIYIAGRYLKLSRNLSQTPWFVDDGNRFKSSVQEKIFSGINAYIKYNDIKFSSSGREDVDVRMLGTGRPFMIEIFNPQWSNNNNNNIIAKIKEYINQMHQDVKVRDLQFVSRNESQKLLKQGEQEKSKTYQAICCIDRSFTEADMIILNSVKDLVICQTTPIRVLHRRTLSDRHRTVHSISARPINVDELINPEWKEFLSQMFVISIVTEAGTYIKEFVHSDFGRTRPNISSLLGNCRADIISLDVLEVKLDWPPMIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0N9</accession>
    <name>A0A922I0N9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-associated and pleckstrin y domains-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RAPH1_3</name>
        <name evidence="3" type="ORF">DERF_008017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0N9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039664">
        <property type="entry name" value="GRB/APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243:SF23">
        <property type="entry name" value="LD06925P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="377"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="437" mass="49193" checksum="C602269142D61FE5" modified="2023-02-22" version="1">MYDTKSPTTAIIGSTSIGQSNNNVGDSTDKEFEDILNQLNALGNTIDQELSQKGTKTKQFSSNSIDDGHHHHIIMQQSSLIETTSSSYPSSNNHYHHHHPYAIHSYHHHPDDDDSTNQILTVVAENNGHNHHDSSGIVMTMDVTQQQQQQQQQQQQPVVSIRTDSPDNDSAFSDSISLISSEQSSTSSTSSGGSKSSMINQRKTNPSGHSSQSVNSSSGSSSCCEEIHQTNIVIDHHQPLMNHTVKSMNENPDKSPIHKQPQQQQQQQIFLEQNDKTNNGDDDSTFLTDNDKDDFDVERRFELITKIIDDINWQIESNIENINDDDDNGGCRDDSSKTVDDTIIDNKHEQNDIHNDKMDFDEKMRKAMAKIHEANVRKLYLKVFAEDDSSKCLLADERMTVGRICQQMAQKNHISLGINYCIIEHIQIHESSTYIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I108</accession>
    <name>A0A922I108_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TOP2A_4</name>
        <name evidence="9" type="ORF">DERF_008748</name>
        <name evidence="8" type="ORF">HUG17_4865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I108"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7641820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9518151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="98" mass="11335" checksum="B5DA154BC906C8C9" modified="2023-02-22" version="1">MDDFPNRPLKAQGSSPPVKKSRIDEPCQIEHILLRPNIGSVEKVTKQMWVYDSQDGMVLRDVSYVPQLYKIFDEILVNIADDKICDQKMTIIKIEINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I155</accession>
    <name>A0A922I155_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I155"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="9336" checksum="021B9B4FFFF0CD47" modified="2023-02-22" version="1">MKKSGFFRGVLDGIRSTVGQQSSSSSSSGAKALLESETEEVLKQSHFKINTVGLKKKFLLLFYSYCNGQVILSTTDSSFSCYIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I203</accession>
    <name>A0A922I203_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_008604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I203"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="142"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9517999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="535" mass="63332" checksum="8C9B6F8F013C719E" modified="2023-02-22" version="1">MEKNRSNEDGTEQQQQQQQQCDDDPSEMIANLMVKNERMKRIIFTKKGGQQQKQQQQQQQQTAMIEELQQLLDDKKVQQKKQQQQQQPNQGRLLNSDEKQSIIKKENIYMNNNNVYNVDGQDNDDNTIIVPETPKWLQFNGYQYQKILGEGTYGKIFCARNIKNGEMVAIKQIDRNNPSIQQWLDNGCLDREMKITLAIRHQNLIGAIDVLKFRSIAFIVMPLIDGGNIRQLMFRQRRPFNERRTKKLFYDMAKGMNYLHRNRIVHRDLKLENLLIHRQYDRLMIGDFGFAKILPSTSSMAIVDSTNMMTTMRRKFDKNQCNSPCGTIEYTAPEVNLIRLNYLENSQFNNQQSYDGKAADIYSMGICLFEMLYFCNTFIKPEEYLQEMNILQRVQLVYRRQMTQQWTENNRVKISTKCSQLLIRLLQINAEQRPTIIEIIENDPWLYRINHREQAKREKLRQITTLIHEYMAMNDDDNDDNNDNDDDNDDYGGGEENQSLVMMKNLEFKQNQTMTNNNKKKLSKTKTMKIRTLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I274</accession>
    <name>A0A922I274_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrator complex subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">INTS2</name>
        <name evidence="5" type="ORF">DERF_007432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026236">
        <property type="entry name" value="Int2_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14750">
        <property type="entry name" value="INTS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02105">
        <property type="entry name" value="INTSUBUNIT2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="632"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="642"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9516706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1302" mass="150937" checksum="82B9F104DF52D041" modified="2023-02-22" version="1">MSTFSIPSSKCFDLIQTLNFDQLDQLSSRDIRYILPCLVRMCHCDTIDSSRKWLENRRKLKRILTTFPEANDIRQVFDIDYVQLESEVKKDLQLRLKSPSQPQPYETYLLSSVFQLFKISNADYAEHSLIKIFEHNDQKLLIRMKLVLNELLTLFIYFKNQSYQLNQLHSGPVASELFDTDIYLDEIVDLIYFAISEMPSTFQLFEIVETLLIVKNGLPLVVRLVANFPESFHEICSTLINNSDSNVIEEQNFISSNRVQVLRKLCQMNQSEALLIRSEAIELCRMPNLIVMLTLDHIRHRDDSNEKTNSDVLSFLTGILLSNDDKIRTWFSQYIKRKNLDTSPQTNCFLEFREQLLRRFRSITETMMNLSNNFSSANGNPKIEESIITEACLMLRLYCALRGVAMMKLNDEETQAISKMIVCRPPHIDIGVRFVSVGLCMILAFPKMIISQETEIIEWIKWLPIRKASFGEMLLLIAIFFHSNQLTQIGELVSSTIGIKHSSRTNELTLIKHIFIQDIFTEQTVTAHAIKVPVTKNLNDSITGALPIHCIYQLLKSRAFTKNKVPIKNWIFQQLCNCRPPIHHILPSLIEAYVNSILLPTSQSAHMTNEPIAEEDLVQVFQRIVYSFEPDQIQKTDRNPSGDEESTDDDQNDSDNDSDDQERMDVDDDETENENDDSNLSTGNAKSSEESLNSVSCLLTSQLLFLYYVLLYEDVRLANIRNVDRPSMTYSSEFMSRLPIFYLIQRTQTCPEEYGLLRPPLLRLISFHYPHLCLVRDWLPRPNFSVSNHRSLFSLHDRHQVKQIVAHRKKLRKLFQTTLRSLKEKLYNQNREPFYYLEQLVKLPDELLWPFATDFIQLLPWILDVDTPKKILLLIRQIWFRLNYIFPTRLWVMTVNILRNGSINGFLSSWNQQNWEDIVMNPNFIFRCDQRVFRIPELMEILLHMIDGFLSASKIKCTHHNMECIGRHTGDEEKKKREELSRIYNLTWDSAAIQMLLDCCSPQIDQNVREKFYQYNPCDKVSKQSSILNHQIDCLLSNRREIQGLICTHLHQRFIADWNLAKTVSTQGYDPEFLPMAVAGIPSLHICLDFIPDILQYTDLSKQSFAIDLTSHLCVQYPIPRSFSIAKLCFEFANIHLTLLPNPKLCQFYLSILPALERMTHTFPPLIEGFLKLLIRLGQRNLSAFAAKPGSKFFLNSTDQILFLPSSSSSSSSSSYETISNEFDANSDSSSLVIKTNNKSLLPDQERFSKSKLIDISWLEFNQNIAKKMSPEESLALAIHKTFAMVCQLSSINRIYRDSSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2D7</accession>
    <name>A0A922I2D7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPL15</name>
        <name evidence="6" type="ORF">DERF_008451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2D7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9517822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="206" mass="24469" checksum="0DA2BBE67DD281D2" modified="2023-02-22" version="1">MGAYKYMQEIWRHKQSDVMRFLLRVRTWQYRQLNVITRCPRPTRTEKARRLGYKAKQGYLIYRVRVRRGGRKRQVPKGATYGKPKNHGVNELKPKRNLQAIAEERVGRRVAHALRILGSYWVGQDSTFKFFEIICIDPFHKAIRRDPKINWICNAVHKHRELRGLTSSGKKHRGLRGSGHGYSKLIGGSRRGNWRRRNTLQLRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2M8</accession>
    <name>A0A922I2M8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Ubiquitin-conjugating enzyme E2 J1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">UBE2J1</name>
        <name evidence="4" type="ORF">DERF_004572</name>
        <name evidence="3" type="ORF">HUG17_0637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2M8"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="10"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7645099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9520891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="231" mass="26197" checksum="3AE91868521C614F" modified="2023-02-22" version="1">MDVNYNLRSPAVKRILLEAKEMKHPTHEYYARPLEDNIFEWHFTVRGASDSDFSGGLYHGRIILPNEYPMKPPSIIMLTPNGRFELNKKICLSISGHHPETWMPSWSIRTVLLAIISFMPTPALGHIGALDYSSEERRALAIKSCHWKCDLCGPIRHHLKSITTNQTTIESGINQSESSSISSGSVIEPTIVHAQQQNYSNWSSWSTLVVLYYSVVMLIIGLLVRRLLSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I304</accession>
    <name>A0A922I304_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_008777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I304"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001667">
        <property type="term" value="P:ameboidal-type cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022412">
        <property type="term" value="P:cellular process involved in reproduction in multicellular organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035099">
        <property type="term" value="P:hemocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035006">
        <property type="term" value="P:melanization defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9518182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="112" mass="12754" checksum="4E972F78D55E701E" modified="2023-02-22" version="1">MSKSTELSVSHHHHHHNHHHTKQQSNLPSKSQQTKVTKKLRKLKCVFIGDDAIGKTSLIVSYTTNGYPTEYVPTAFDTYSERSIFTTSIHPQTFVIIISAKKANLYYSNIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3E0</accession>
    <name>A0A922I3E0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_004177</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3E0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9520468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="192" mass="22776" checksum="D6D4CE007D8AB3BD" modified="2023-02-22" version="1">MAHWSDYSLRGWLSFLAFMHIGLCLRSFFDPNFLFGKIFHTTIHKEMVFVHYFGCYSIIQAFILIQSAIHLYVLPLQTITIFLLIVFITLIMVESFYYCTLDLYGATLLPFMMSVISLIWLILFHFIWKPWLHVEINEDIVKSCLLHPGHHQGHHHNKRHKSNHHHHHQYSDRMSISSSSITNHRYGKIHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3K6</accession>
    <name>A0A922I3K6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Structural constituent of cuticle-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_004340</name>
        <name evidence="5" type="ORF">HUG17_0472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3K6"/>
    <dbReference type="OrthoDB" id="6515429at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324700" evidence="4">
        <location>
            <begin position="21"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7644934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9520640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="314" mass="30435" checksum="B4CD59DC0938F3A4" modified="2023-02-22" version="1">MKNINLIVVLLLATIYSTYAARYIRSVKGGRGFGGSAGGYQSSSPLSPSRTRFSGGGGGGGLSSSYGGSSSGFPSSGGSLGGSYGGSGGAPTSTGSYGAGGGGFGGGQYAEEEHPAPEPYNFQYAANDEYGNNQYRNEEQDQSGTIRGSYGYTDANGLYRVVDYVADNDGFRASIRSNEPGGLTEPNPTTGSVDSPADVQLSPDTVPASVRQQQEQYTSAAAGSGRYRGGGSSGGYGGNAGTSGGSGYSGGSSSGGGGGGFSFGGGSSSHGGGASGYGGGFSGTSGGGGGGSSSGGYRGGAAGPITQQKLSGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I407</accession>
    <name>A0A922I407_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I407"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="120" mass="13129" checksum="9242A4CE9C0E453F" modified="2023-02-22" version="1">MEYSTTTTTTTTTINKESLDCNDNHQNKTETKQNIELKRLQFGFQLWPFILSLASISFSISSSSSSSRDRLLWLWLNSSSSSTLISSSSLSSSRDFGRKNALKFDGKFGIAVGIGAGGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4M0</accession>
    <name>A0A922I4M0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small ribosomal subunit protein mS40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S18-2, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">28S ribosomal protein S18b, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MRPS18B</name>
        <name evidence="12" type="ORF">DERF_005724</name>
        <name evidence="11" type="ORF">HUG17_3337</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4M0"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040054">
        <property type="entry name" value="MRPS18B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13329">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S18B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13329:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7639304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9522124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="194" mass="23341" checksum="B6B82BD78650E30D" modified="2023-02-22" version="1">MNQIIPMTRFLRQNLSTITSYRRIISMNANQIRFCSQDKRNDDTKTNRKQIERENRDRRIPVELDTSIRYMKSDAFKETYQDYKIWELFRRNFKGQFSPAVPRLSCVGDDGFVKTSNPCAICRDRYLVLHHKNIELLRQFISPHTGYVYSNSILCLCHEQYEKLCVAVTLAKNYGYIDFEVPHRHYDYQYHYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5X4</accession>
    <name>A0A922I5X4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5X4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="98" mass="11250" checksum="A8948332F4984686" modified="2023-02-22" version="1">MKTATNNVTLANDDHFYFEMKCFTCDDDDDDDDVNVPQATIRINSACQLHLYNKFNEMCLIQVSELRSSVFVFDPEWLESIQSIVGLSNVSNCIAFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5X5</accession>
    <name>A0A922I5X5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5X5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="449" mass="53131" checksum="C8DB38686877813C" modified="2023-02-22" version="1">MNDKIEQSENVNKYEFNTISDKKDFGSLGIPNYIIEYDPLNLVIKCPRYHRFMTNEKSEISIDDLDQIQLEMETLLLDTMKRLRLLKNELNANEIKMLKNNIDASSSSSSSSSKSKTEIKQPYNEKTFEKYFDRITFKSKANCALQPNYEIIERFIAMPYPQLNDVDVPNQFWSFIHYLHDIPPKEEEVKQCASFYGKCEMLDDDISRMNDTNIKTIDHGDNNDNQNDEKQQDEKLDQYLEKFIHQFSNDETNPEKSYGPLTKRLMASFIKIDNNDETIGKCETAETLDDENVKTENLETDDSIQQSEKNEEKKQPSNRQQNPIEIEPHRSHKFERSLHKVLKQLDLLHSHPKYTNGKKLEKIRQSLSSSHRLAELKKNYKHAFNDLIHDRMDQKLRSTFIKMFNTYKSIRSSKSNGENDINVDDYRQFDQLWQTRVRLLKYLNLFNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7B8</accession>
    <name>A0A922I7B8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Epithelial splicing regulatory protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ESRP2</name>
        <name evidence="9" type="ORF">DERF_006330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ESRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7B8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12743">
        <property type="entry name" value="RRM3_Fusilli"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000041">
        <property type="entry name" value="Epithelial splicing regulatory protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="496"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="605"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="652"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="912"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="652"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9522770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="939" mass="106066" checksum="BD3FA977EFA2D75F" modified="2023-02-22" version="1">MVDHHHQHLNNQQNDCRYLIVVHVVTAGQQDDDLGSDEEEIVLFAWLVIDTTILKVLEKRFEYVRPKNKDINDNILSEAARDSYGISEEKIKYASTLENVIHQMDQYINTHLIGDKLNNQQPQLRPSPPSSTTQCPKHSDNYFENTDTDTCCSSSSSTSTSTSTTPPTNDDYDNDDDEMNNNNNNNQTDYPNKERIMMMTNGHYVNNNSNSNDQQQQQQHYNGIQLITDGQLHLRQVLHPEAVKKSIDLPEYFYQFFDLRKEFRKFYRNNDMKTLDDMIDYLSFKNNDSTTSTVTATTTTMTTMTTMTTNSNASLTASTSSPPSPSSTTTTTTMNQQQPQQEINELELVQMKLSNMVTIINRLLIDGHRFDELQIINDKLEPGICSKNELVDNNTVVRARGLPWQSSDKDIANFFKGLNIIKGGVALCLSVQGRRNGEALIRFVNQEHRDMALKRHKHHIGQRYIEVYRASGDDFLNVAGGNNNEAQAFLSKGGQAIIRMRGLPYDCTAQQVIDFFASNGHKCDVMNGDEGVLFVRKPDGRPTGDAFVLFETEDIAVRSLQKHRELIGSRYIELFRSTTAEVQQVFNRNMEARIYADLNGLINCHNHNHHHHQHQHQHHHQQHQQQQQLQVNTQQQQQSLLPALVTQSLLQQQQQQQQQQQSQNSHPHQLQHHLHHHHNHPLQQQQNRKDCIKLRGLPYEAQVEQILEFLGEHSKNIVFQGVHMVYNAQGQPSGEAFIQMDSEQSALLAAQNRHHRYMIFGKKQRYIEVFQCSVEDMNLTSGGFNLQRQSLLSSATPLLPPPPPPFGAFSFGHPVTLTAAAAAAAAAAAAAASNNVQHPVLSLNGTSTIQPHTAVQAAAAAAAAASRLQSTSTTSSSSYGQHTNPFNLVYWPYPSPPVSPTAYAAAFASNNLNHHNHNNHHHHHHQQPTPAMVNMRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7K5</accession>
    <name>A0A922I7K5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7K5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="45" mass="5077" checksum="DD2F8A6685235459" modified="2023-02-22" version="1">MRLSLYIHLKISHHCVESPAETVFPGSRIQQQQQQKSKLTAVSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8I8</accession>
    <name>A0A922I8I8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tachykinin-like peptides receptor 86c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_000423</name>
        <name evidence="12" type="ORF">HUG17_8231</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8I8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="8"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7640762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9526325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="404" mass="45474" checksum="27B3357A6AFC8296" modified="2023-02-22" version="1" fragment="single">MITVGLLANLLVLATIGGHKSLHTVTNCFLLNLTVSDLVTLLFNATFNFVFMITGHWPFGHRYCVVNNFITNLTIAISVFTIMFTSKERYNAIVYPLEKRMTKNRALINILIIWIASAIFAIPALIFSRTLHDTSMQRTVCLMVWPDGYPGKSKLDFFYNLLFLVLTYLLPLMTMAIAYTLMARVLWGSKQIGETSQAQASLVRSKQKVVRMLICVVIVFAVCWLPYHVYFLTTYQWPELTTARGIQHIFLAIYWLAMFNSVLNPIILLLMNKRFRRYSTKFLNFWPLNRAFNSDAASSLTTNAAAPVAQQFNNNTSGGQRPSNLIMVVKSHSPNFNRTTSELLGDGGGGGFAVNHISNEQNLSNEILPNHHNFSSLSSPTLSNMADNNTTVKNSFYSPLVVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8V5</accession>
    <name>A0A922I8V5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001133</name>
        <name evidence="2" type="ORF">HUG17_4365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8V5"/>
    <dbReference type="OrthoDB" id="6521000at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="420" mass="49700" checksum="C868C66F1B5CB21F" modified="2023-02-22" version="1">MTTKQLVLSHIDQWIMMEQQHRMIRLLLNTFGILGVQLRPLQWNNVLSILNWSLNNLIIVATLYLLNDQKPFHSRLASLISSDQYLMYYYVKICAKIIFPIICLFYVITYWIYGHRLISQLQSSRFASIKIPKRVENIVIIVAFVIPMFFLCLRNYLPFDSFNLQTLFAIEIFTFYRSVTWILLYFNQLANLRVLEQIRQRYLHDDIEKQLANGRKCQSLCLRRQSRCISSISASLEKIGKRNDPIRHTLKNQSSITKCRDLFEEMKDLAELNNRLQPMFSILTTLHLVHTSAVVTILLNDIAMADFPYNLGYFVEILFRISVWFGLLTLNRKVLQNFDQIEGFMLRKLRKVRPNQTLPSTTNSSPLKCSKVLKFKEMNIYQQSFHLLLFDVLRIDLKFLLDWICFIASYATLIHQTRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB07</accession>
    <name>A0A922IB07_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">YARS1</name>
        <name evidence="18" type="ORF">DERF_001502</name>
        <name evidence="17" type="ORF">HUG17_4649</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10221"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="15"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB07"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 14" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="353"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7641604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9527492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="522" mass="59285" checksum="91C6CED372DFA051" modified="2023-02-22" version="1">MSQESSSEEKFQLISRNVQEILGEDRMKEILKQRDLKIYWGTATTGKPHIAYFVPLCKMSDFLKAGCQVTILFADLHAYLDNMKAPWELLKHRTEYYECLIKTVLESINVPLDKLKFVRGTEYQLSKEFTLDVYRLSSILTEHDAKKAGAEVVKQVQHPMISSLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPMMGYTKRIHLMNPMVPGLTGGKMSSSEEDSKIDLLDSAEDVKRKIKRAFCEPGNIEDNGILSFFKHVLFSLFNEIVVERKFDGNITYTNYMDMEKDFQTQTLHPGDLKQCTEKYLNKLLEPIREKFKDPEFKKLTELAYPKVSKKGGAAQEPGPEILEIRVGRICEIEKHPEADSLYLTKTDVGDPSGPRNIVCGLAQLIPAEELLNRLVVVLCNLKPAKIRGVVSSGMILCASVSEPRKVEPLDPPADSQPGDLILFESITDDKENTPTTFQIIDPKKKVWEKLQVNLTTSSDRIAQWKYSILKTDKGPISCKSLKDTPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBX0</accession>
    <name>A0A922IBX0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SWI/SNF complex subunit smarcc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SMARCC1</name>
        <name evidence="13" type="ORF">DERF_000606</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMARCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048858">
        <property type="term" value="P:cell projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049898">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032450">
        <property type="entry name" value="SMARCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032448">
        <property type="entry name" value="SWIRM-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381:SF1">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16496">
        <property type="entry name" value="SWIRM-assoc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16498">
        <property type="entry name" value="SWIRM-assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52032">
        <property type="entry name" value="MARR_BRCT_CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="6"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="10">
        <location>
            <begin position="531"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="720"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="725"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="833"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1218"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1461"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1055"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="858"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="916"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="952"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="976"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1098"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1121"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1174"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1218"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1234"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1287"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1314"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1356"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1380"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1461"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1508"/>
            <end position="1519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9526529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1519" mass="168543" checksum="7B8C5184A6220480" modified="2023-02-22" version="1">MANNIQFKKKDNNNGLNLKFFESSETIQLFDTIRQWLQKNCKKFVQIDPPTNKSLANLTCQLLQFQEDSLGKNGSISTTSSGGGGVGDSGGDSSTTTATTTGSGTTTTTETSSSTATTKQQQLFQRLPYKCFIDFKSGGKLCRIFEFVFKFKTEQGWRRFDFQSQSRMDRNVEMFIGLYKFLQTNQCLIEPHVYILPEVDKVLATKLRDIIKRYHAKCLESPNEATHIVYPTTVAATQHTDSNGDEFVRIVMKRDRSLLVHCLGRPDSYDTWLNIDVDLEPENERDHNDTPYELSANWLLDTDEYNEWMNEEDYEIDVDRNGKRIPKRSRFTIEELHNEEKRDKRSNSIQKSKRRRSPSPQSDKKRSRGKGASARSPAPVTMTNSNKKKFKNEDDEDLTKDMDNPSPETHFQVVNLNRNSISAGNRNQKDNESMPIKGGTIIDLDSNDYDQQDQQQSKHLNNNSSNNNATDGGGNGGKPSSRSASPSSNRNYHQQSNGTSGLVSINNHSSSNNFDKDDSQDDNVTEQANHIIIPSYASWFDYNCIHAVERRALPEFFNGRNKSKTPEVYIAYRNFMIDTYRLNPTEYLTLTAVRRNIAGDVCAIMRVHAFLEQWGLINYQVDVDARPTPMGPPSTSHFHVLVDTPSGLQPLNPPRGQVSASNSSSSSATQQMLNLPKENGVGLSSKKESENINGFGDNFGLKLDQYARKNSYFKSKAAANLSREWTEQETLLLLEALELYKDDWNKVCEHIGSRTQDECILHFLRLPIEDPYLEDTNNALGPLSYHPIPFSKSGNPIMSTVAFLASVVDPRIAASAAKAAMDEFAKLKDEIPPSLAEQHSKNVDASSSSAAESNNVRSDQKTTASDKTEKVSSEVEKDKDNRNKDEVSINGGDADQQVIKQEAASEDSSASSTDNNNKKDKEDGKMDVDGQREESSSSQQSADKSSKESDVSSEQQQQTKDGQQQSEQLSSTDVTMADKNDTVNTKTKDKEKELTEKEKNVIKESQISVAAAAALGSAAVKARHLAAIEERKIKSLVALLVETQMKKLEIKLKHFEELEAIMDREKETLEYQRQQLMQERQQFHMEQIKAAENRARSQAQQMFYQQQQQQQQQQQQQQSQDNRLNQHLNITASGAAPPTVIPPASQIPQPPPPSQTAQQIAPHMQIRPPPPQIPSTVQQQHPGMTPQQSHLPQPPSATNVPVGNNVVMAPSVGEIAIQQSQPQQPTISNPQTQHPSFLSTSHQQIGGSSMPQSQMTIPQQKPQHPVSSTLQQQPNVAPPLSSITSVPQQQQQDSDLPQTLQTPSTTQPEMVISHPQTSQQPVATIMPQQQQSSNNTPTATPAVPMNYPSLNANNANQVQNIPVHQQQQQQPPLSSTFVEPQQQQQPQPITTSSDPATMSSSSSQQPLLETIPTTELQHTNPVIATNTAQNSSVEQQNIVTAAPAIIPTTIQQPIVPQQQVISNNNNNNDQPQASLASAAAQQPPQSNNDTVTTATTSSAAVPVTVLTNTAATNENQSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC12</accession>
    <name>A0A922IC12_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC12"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8918" checksum="22D6BD5A735DFE0A" modified="2023-02-22" version="1">MEIRYESVIWRRAIHGNKISAIFDLVRIFVFVYKGYIRYFNKIEFADVIYVNVIRNYSISVGTNNEINHFQQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC50</accession>
    <name>A0A922IC50_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC50"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7786" checksum="EC85933DA2AE4BC5" modified="2023-02-22" version="1" fragment="single">HFYITKHQHLPTYVKSEELKLTSGKKYYYNSVYRKESRKKESSSSTNNNNQVSTMKNSPSDNDKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC98</accession>
    <name>A0A922IC98_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_001444</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC98"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19697">
        <property type="entry name" value="bHLH-PAS_NPAS4_PASD10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000081">
        <property type="entry name" value="Dysfusion, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056192">
        <property type="entry name" value="bHLH_NPAS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043:SF39">
        <property type="entry name" value="DYSFUSION, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23043">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23183">
        <property type="entry name" value="bHLH_NPAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14598">
        <property type="entry name" value="PAS_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="112"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="584"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="812"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="909"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1033"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="841"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="869"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1043"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1085"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9527430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1147" mass="128652" checksum="28B63834946306D0" modified="2023-02-22" version="1" fragment="single">FDATKSTKGASKLRRDLINSEIANLRDLLPLPSSTRQRLSQLQLMALVCVYVRKANYFQYAFRKHELIQSHHHHHNHQHHHHHQHHHHHHHQQQQQQHYNHQLSMTNFGFSKALNGFLMMMTQNGKLLYISDNAAEYLGHSMEDLLIHGDSVYDIIEKQDHQTIQNELMRSSSSNPSSSSSTISDGRIFLCRMNVSRNSRRQMRFGDQKVVLVQGHFVSYLPLCSRNEPVFLATCTPVAMPETRECVVQGSTNVFTSIHSMDMKFIHLDSNGEFHLGYRKNRLKNLSWYDIIHWDNLKEAQSKHRLIIQSEQERSCILLLRLQTNSMQWIWVHVVLQVKDNNENSQQPVIVCTNQVLSEKEATIMQTNQWLYQFYSLHSKMHYLQNSTTGTSSSGGIMTSVPSSPTPSCNSNTSNNYNDHHLQQQQQQQSSSSTAATTSNSSYTTDNNNDYTNANDDSTITGSSSSSSTTSAAAAATTTTTFHATEAPNLVIHPTHSNSNDFSSYSNGMSIQTNSSTNNNSGQYDNYGIHTQYSSSSSSSMAQLQQYSPQAGTLPYQTNQTQTTNLNHVPNTPPATAAIEHCIKEEQTSSSSPPPPPMITKTTRTKRNRQNGTNNNEPSNNKRSKNKKNQSNNNLANVTATTTANTITTTNLNDQLSSSYEFYRNNHNSTMTNSNQSTYPSAYHHRSSTGSMFGSSSGTSNTDLSMITPATYYGSSIGSAYTGHHHPQMAHYHHPHQSHYHSHQNHKSFTIFDHETVGVTPIMHHQYTPSALATGGYTDIHQHQPQTSEIPMVSSAFITAKTATSIRNISKNYSTNDISNNNNNNNNNNDRRDLDKVRSPESITSTTSDYGSMTSQSPPSMFEKQSPFSTTTTTTTSLSSSISTTSSSSSTTSNFPNSTMNFEPMYSHSYHHHHHHQKNNHWPIHSNNNNNNNSDQQKSLQHHQNDDTFHSTFPRLSSFHQFWPGYATAAAAAAAAANSTVINSNGESFGDHTVTATTAATHQYYNGDHRQSPHHHPHLASTFPMDSLLHHHHHSQTTYGTTNHHHHGHGHQHSLFTPYGSSTTTTTSSNDNIGHHYETELTKANLVNNNNRSSSPTTITARGKNDSSKISQDSTTKNNNIYYGCCFIIFERTSGKHQNGISYHYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICD6</accession>
    <name>A0A922ICD6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICD6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="130" mass="14720" checksum="4BFB666603BD9435" modified="2023-02-22" version="1">MEHWTVVNTIIKQKLTQQQRIQPTIIISNHSFNQSTNLRENYLNFSTSTETNTNNNNCNNRPPAIRSNSSASSLYPSLNSNNNNIQPSPNSSSSPTKSFTGNVCDDDYDDRNRCLLLIDGVLLPYRNNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICW7</accession>
    <name>A0A922ICW7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICW7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="7353" checksum="8E7465C93F0D7943" modified="2023-02-22" version="1">MLLFTFDLCSEFELFSNVDCYTLIRDFQIVDLTNCRSIKFLGFSNLVLTNNRLIICYRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ID72</accession>
    <name>A0A922ID72_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">POLR1C_1</name>
        <name evidence="7" type="ORF">DERF_003255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ID72"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9529366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="234" mass="27447" checksum="B4EED3DDD6454997" modified="2023-02-22" version="1">MLNNQVFLYSTFSMITLFICWSWTTAIEQHEQIINNNHSGNNSIKSKVKIDVYYETLCPDSIQFLLHQLVTNYDRIKEKVDLHMYPFGKAQFFESGNSYEFYCQHGPKECRGNMIHCCVLDQNSHDISFPFIKCMEKELYGLRRPDINVVSQKCANWTNIDWKYVDECASGNRGKQLLVEAGRKTKAIKPKISFVPTIIFNEKYSDRIQNQALYGDFVKLIENHYNKNNEHKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFC9</accession>
    <name>A0A922IFC9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFC9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="53" mass="6161" checksum="61F26C326B95FE08" modified="2023-02-22" version="1">MDYIKLIQIRTIVGKAFQSREIQILSDWYWVADHSLKRAGLVYSVTGLILSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG01</accession>
    <name>A0A922IG01_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kv channel-interacting protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KCNIP4_1</name>
        <name evidence="3" type="ORF">DERF_003819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG01"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9529971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="8171" checksum="4AB3013506F9B25D" modified="2023-02-22" version="1">MHLITNAIYELLGECAIPLSDIRNAKEHADLFFHKIDLDKDGLISFEEFVNWCKKDSNRLAEFQKFDTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG38</accession>
    <name>A0A922IG38_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG38"/>
    <dbReference type="OrthoDB" id="6408053at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036952640" evidence="1">
        <location>
            <begin position="31"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="203" mass="23733" checksum="E975345637622712" modified="2023-02-22" version="1">MYVLQHSSKILFRHWLLFLLATFMINYMMAEPAAERVNCRRVVFHPYCRGISAKRSSMQLKDASDMPPSLESIKKSLPKIWQQLLIPDTRQRIIERFNSEQSIPRTMKAVIVDDNNSADTNHSEPNPKLDSHLNHEFRAEPFQVPPYLFGHKQSNIEPDIKSTSSEEEISETNPLIFHLRMVSYPEFMQFFSRLTSIPKHSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGQ7</accession>
    <name>A0A922IGQ7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_003481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="523"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="668"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="863"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="998"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1176"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1346"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1411"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="577"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1018"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1126"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1248"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1542"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1025"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1038"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1253"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1559"/>
            <end position="1573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9529604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1587" mass="181396" checksum="6AF2109E5018FC18" modified="2023-02-22" version="1">MSFKNTTTVVSTKLTFPCTECNFEAQSARQLSRHKAVSHTQNALKCVLCPFLTAYQTNLLRHRKDVHGICGSKGNKSCKFCGFVSEDNDTLIQHQIEFHQDILKTAQAKFAKELVSAGGEESVADFSANFESMSEDLMNNKNNSSNSANIVHTGNKKRATLKNLDKHQQHNFKSSTNSMKLMTANNDVVADDDDRAEFEEFWKAGFIDQQYDDHSNYFGSHTAPLITMKTADITQNESVPTTSSRSSTPKSHSSSNVMNVNNMSNNNLNNMNNNNSIADLPATRIRRQYNCNDCGFRTVNPREFLYHRRDGHGYKVKIVECPYCVYACQYVQKLQRHLLLVHKLTSIMDSPSEQGGANGELEQLLVKRKYRRTSRPIETNSIEQNVNHLETINDDAASPLDNDYEQMDRNPDFEPMDSFEMNLNEYHEENEDVEMESNASNNDSDDKKFMFNLECYICKIKFGDAISAQKHFLKHHKHSNYKGMVPIMKNHDQNLEESTSWNGQPTTTTNQKKVFDSNAKNIHVCNFCGYKTRWISELERHIRVHSKDKPFKCLFCNFRSKWKGDLNRHIQRYHSNEANLQDLESSDNSTNGGGGIPISSNNMSPDDNQDDTMNEDSCMTNGDYEMSEMDDDNTGLGQDDQINPNVQDNEIFDLDNSEIMNGNIAKMYKCTYCDFTCSTASRFHVHYVQHLNTKPFQCSVCGHRSNWEWDVTKHIKMKAQRDPIHEKAHPVLIHDSGKRDYSKYNKFVVWIGREEADIANEVNNRIDFRARRFKNESDECENEDNGFNETARSLLIPEVNFEIDDEFGVEGCTIRKYSTRSSIVFRHPNSSSKPISCSQCDFRHHFARVMVAHMSSHNQAKPYGCTECSFETKWKEMILDHYSNIHENRNPNEFQIRFRCAIDENSICRILSADEVDRFEKNNVSKISISVVGSTPPSHSTSTASITLQNDHQNSSLIEPNIYEEKTVIRCELCPFITTNMKKMSIHCRFHNPSKGSLKCKQCPYYINNPDKLMRHQKLHQKTDSVSLSAPSSLSTSHYRTNINNESSNDVDYQHQSKLKYSSLISCSLCSFQTSNVQTLNDHMNNSHNLIHSSQTNLAIDDNIGDNGDYELSENILEQTLVENDYKDSSSPQNNENHDCVHSSSSNSKNYGDDKHNNLIAVDSIKNGDEAKIFSYVCPDCPAAFKSPGDYNVHAHFHSSNYQHACPYCTYKARNKPQLCKHLYVHTAEYIAKRASSYPQGTKLKVENQINVTKSNSNDQTSSSSSSKTNSTNNMVNKPSMKKTVRKHRTKIPFPMKPVKARLNSEENGKQNIIFKSNDLMASQEFLETKEYLQRINSGIKNRCMYRCSKCPAVFTKVNTLIYHTSLHEQNSRFTCESCNYSTETEDNLSIHSLLHNLTESQSALGYNFNYNCHKCPAGFSKRSRLEKHLSLHGAQFNWKCDKCDYSVRYAATLVKHRAIHLINPNFQAMEYGQFDNTANDDEVRDEAQQHSYAVHQESNDVEDCENYTKPDLKLKLNLTKLRDNLHVAGTSLKKIQLEDDNDQGCDDYSVANMSSNGQDEDDEDLPYADDDNINPALLLEESVMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IH26</accession>
    <name>A0A922IH26_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NUDT3_1</name>
        <name evidence="11" type="ORF">DERF_003907</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.</text>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family. DIPP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IH26"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="15"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9530069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="283" mass="32102" checksum="28281470119B3425" modified="2023-02-22" version="1">MVKEKQVRTYDQDGFRRRAACLCVHDPDESEIMLVTSTRAPEYWIVPGGGVEPNEDPTQAAIRETEEEAGVKGVVKRSLGDIEVFYILEKKINLNFFREKKQLQNTQRKHRTSVFVLEVHEELDDYEDSKSRKRCWFPVQEALKLLAIYKPVQCTYIKLMIQTSSSPKLHLLLSSDQLTATTTATFNGPSSSTTIATIISKNNNLIDSSSSKNYDSQSINHNEQTKFISLSSTTTTTTTTSIQCNDNDDDDDDEHGIMTQNQCDLMTTKTNSLQPRRNLYPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KSW5</accession>
    <name>A0A922KSW5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA damage-regulated autophagy modulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DRAM2_9</name>
        <name evidence="8" type="ORF">DERF_014373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KSW5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="45"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9493633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="284" mass="33257" checksum="DF305BDE2B78F2B1" modified="2023-02-22" version="1">MLATNIIDVDLEKNPPSSSIKSNNNMTIDNENPLEYFRKYFQYIWIFVFTLPLLLSIFFLLCYYITVKNGFVYPLFPYISDTGGHPPVACYFSMMIDIIALLVFIAGLFRYKQIEYYLSREKTATINAERQWLINLNYYSLIATWISPIGLIMIGNFRETENIHPHMAGFLVFWLPITYYMFAAIKIIDHIDCESSAITIRLQSWLSLISISIFIISMPISGYQRGNIMANLNNEIRQHWSPDDDGYEWHIFGAICEWIGIITSLSFISSIGLRMRRFEYWQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KUA1</accession>
    <name>A0A922KUA1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KUA1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037702250" evidence="1">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="173" mass="17983" checksum="046E3A21384E97E7" modified="2023-02-22" version="1">MFKQIIVISAFVSVAIAGGLKTAGYGAGYGAGYGGLIASGPALAPGLALAAPALAPAALVSGPAYAKTAAYASAPAIVTAAVQSRHHVQYYDVPTTRQITPITIDVGANVIPVNMIFRSASSQLNVEQNHLNQGGSVQETASQDEPHILRHSVQKPILQEIREMALKQNEQHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KUX1</accession>
    <name>A0A922KUX1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KUX1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="9769" checksum="4B361E41ECA42FE0" modified="2023-02-22" version="1">MASGFRSSKYHHSQQHQQQQQQDKDHQQQFYPRSETLQSLDVNFNQQQQLQQNSEQQSSTTTFNPDDMDLSNYCNSSSIISNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KW37</accession>
    <name>A0A922KW37_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COMM domain-containing protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">COMMD10</name>
        <name evidence="3" type="ORF">DERF_013252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KW37"/>
    <dbReference type="OrthoDB" id="77522at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037361">
        <property type="entry name" value="COMMD10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12333">
        <property type="entry name" value="COMM DOMAIN CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12333:SF0">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="2">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="254" mass="29509" checksum="F379B3A4534A32B3" modified="2023-02-22" version="1">MDNNVLNLLLAKYSEHINQLDSNTFQKLFKLVFEHFHHCITINIGRGNQLVSDNNHHNQQQQQQLAFTHSDLTLSTLTTVGVSGDHHHHHHHYNNNDDDDNNNDQLGKLLQNSTLANIDNINIIAKSLLNLYYECARSNAKSRTVKNILTEAGWSEEKQTIFIEHWHQNATEIFDILKTKSFNSSAEYLLKNVDRKIKILTDHSNTSKPKLPLGEINFEFNDSHNLTLNFNHSELLNFYDQIEQIQNKIDKLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY52</accession>
    <name>A0A922KY52_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY52"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="8312" checksum="5D830126E64D3CB1" modified="2023-02-22" version="1">MTISLSTLRIENHPYSFSLRPYHVEKTGSRLITKVKLRRAELVLGRGTTWEHSTSFCYFEQKNYYVSRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYB1</accession>
    <name>A0A922KYB1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nose resistant-to-fluoxetine protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_015933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1144"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1307"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1343"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1427"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1454"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1496"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1547"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1582"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1623"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1656"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="982"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1723"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1743"/>
            <end position="1754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9491202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1813" mass="210774" checksum="7732AB6E1B3CDA3E" modified="2023-02-22" version="1">MNNEQQRNNNDNDDADNYNYKYNLSLVERLSMLTFELHSDLIQFYELYEQHLEPMLSDPLLISSSQSSSTITNDSLESIRQRQSMIVERFQEWLAMDDDDDDDDDDGDGQSNVDEDDDDDDLIDESLVLTSSGQLDDENDEERINKRKIRKRIIMNNLAARSRKHAYKVLQFCLQIYLDLYLLRQFFRDIRETLLVERSGYEQQLIESYRQELDLCIEHLLTKEYVEMKCLIEEYYKFRNHQPILPYHHFSIKMIECDQIMKTKSILAELDKDEQIRFKFIDHLIEDSKTFTLETMNTDVLKDCCSFIYSTMENSSSSNTNADADDHNDNLQPSTNDSNELRTKERSKRSSKSATKLSSSDVPVNRELLDEFVFQMYYKYVIEAMATTNVLDDNNGDGKKLRLDTALAKSLKIRKDKSIECQLCIEPVRFESMLELNLHMNDCHPPPPTSLPLPPISTTATSTTTVIQNQQSTVTKNKITNRHSRSKKKISNQTNGSSNHDDNVNVQDGDRDKDGPANLFIQSMIIEQVKKMAAKQKSRNKKNQQTDDSDGNQMNDVDKQVNCMKKSSNDNECSAYDQQQKLLETCMFDPEEGSFVLPVEIIQHLMNTDNPNYSWEQLVVDIQSGNLNFNNPLEKVFDDDGECVDLPDDFIDNDDEKLKLEETLHQTDKISGTINGHHPNQTVQIDSMVNIDEQTLKQSKIQRQHQRNHRRLLRKFERKISRLLTEKGDWKNESVWLTLRNRVRDDFIELIRKSANGFNANTSTITTTTTSSVATNDDPIVTSSIQPSLSSSRLPEIRTESNNDGNRILSSSSSSLIYNDHHNDNHHDQCRRRQDSSTTSSSPPPPSSLVPRQTQSSASKQLKNDMVKSFYNENDNIPQILCRRCQNPTAVNDYNQTNNHDDDDDQSICECNESHSIEVFHYLNNLYEQNKNEPIVKHVDSFNDTMAIVDHLVKIVGKIINLEVDQQQMMILADIVINTNISNECLWSLAKISSGVFDRQIWALKFLDAFGKFPTGIAEGSFSHFGEYDESKIIIPYPPTFNPMYQPSIDTLYVRHHFEYFINFLRLYNLDNYLTMRKVVEKLNNQHGTWLRLGVCFPTACQSNEFELLLNEIFYPVFKLPIELEPDCYDRQTYARKSYDNYEFYALIILSTIIIVNLICTACHFGCIAFCCQPMTESNNSMPLQKLFFRLSKSQLFKWIICFSIIANTEALFDFHCYDDPMIKQQMMTTNNDDDDDDKKSTKQKNHHHHHHKTIDRFKCIDVVRLFLVINVCVDHMFLFPPFMAFMSFKRILNSVITKAYDYNRYFFARNILIIDTMFLISGLLLSYSLLRKLAINRGRFNYIVFTIRLWLKYSIPMFFIVQLFWLLPLSGDGPLWNMGMKMLVNTCKESDSLLSSFTYLSNYRIRSNQNVFNFDQKFALCNPPTWFLSALFQLQIIGPLFILAIYHYQRFGLGLNIFMVLFGCYTSILPDHLFGQLTYMDGPSFSSLEELTHSFVAYHMGINQYLISFFLGIIIGFLIIQRQIQMNPNQSINNDDRKKIIVEKLWLKRILWIMAIVGLIISIYWFMTLHTMNVAPSRTSILLWFSIGKLIGCLSIAWMLYELCIGQAIIIEKIFSIRLFQFLSRLTFGIYLLHFLPLAHRLFTVRDSYVMTDKLLFEFILIDFIQTSIMAAIFYVIIERPFNNFTTMIVLNIATMTNKSHCNDNIIDRIIDNHNECIDSADIKDDDDGDGNKRKFSQYHQNGHDEMTNDSHQKQQYQYQYQSQHASSSSIDQNNNNNSLSLSHQVIKIEIQDLKLSLPQVNLFTANCGDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYE8</accession>
    <name>A0A922KYE8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_010681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYE8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036795088" evidence="3">
        <location>
            <begin position="22"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9505915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="494" mass="57471" checksum="0BDD97B536ACF789" modified="2023-02-22" version="1">MFAKWLKFFTFIMMVTTIVESQLKYHIFPSKTSYGWSLSSCGHGLHNTSRSIKCGTEFLNQTIGLSFYDNKLYQFIIDDNNVIKVIVYFDQSKHIILDGQSIHIKLSDGSQYKLSEIDLSLANFLQEHDFHIAVNMALVVASHHSDHVNGTLLFAFIYRFIVNNYQYGYHYKSNGNLIVGDMRNCIYNQNCPIKFSRVILINTADRVLVFTSKLDDDPRNFVLQNFQLNETIGYICMMKRKKNFLELSQKPCQSNYHEIKENDRLMQFDYGFVITNRLYLISKMNQKIWQINSQILSEYGKQFSIEIRTTYNFFICIYDVAAESSTEMTTPTTIYANGGWTTKKNFHINSSSSATTEHHQTTIATTTTMCPMDIGYEISMQSTEEEPEMTIKNNDNDNDDDKKESTTMKYFHEAINRKTNNSFLITGCIFIIIMALIGTALFLWTESDNNYKKMKNNLKSTKRLFHLTKSNRLVFNNNNNNRYYPTNHTTKSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZM1</accession>
    <name>A0A922KZM1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZM1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="81" mass="9633" checksum="47D71E1F344EFEF9" modified="2023-02-22" version="1">MYKNINLQEEYDDDDDDTNNCASIHIANSLNCNEKEKKKFPIHCVLRSDYISFLNQENTQLINEILYIRKKILVFCCNNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L072</accession>
    <name>A0A922L072_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L072"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="118" mass="12799" checksum="C0CD1D977B636754" modified="2023-02-22" version="1">MFNANGVPDTIVPSSTCTPRTIGSRLLNIQLAFSRSCAAILTPTDPYTTRNSSYGDLTRNSFNGCGTSNARICLYRGQVWLSLPIQLHPMNPIDNGYVWPLILPIPSPVCADVGTNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L118</accession>
    <name>A0A922L118_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HIV Tat-specific factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HTATSF1_2</name>
        <name evidence="2" type="ORF">DERF_014169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L118"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7870" checksum="1E32393E2D1D878D" modified="2023-02-22" version="1">MATINNDDVDDNDNDFAYQLEQEEFERQQKRQQQSCGENSNIYRDPTDGTEYEWDPMKKSMVSENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1J9</accession>
    <name>A0A922L1J9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Charged multivesicular body protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CHMP6</name>
        <name evidence="10" type="ORF">DERF_014731</name>
        <name evidence="9" type="ORF">HUG17_6498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7644136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1J9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7644136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9494007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="215" mass="24741" checksum="6268DEBBCC94588B" modified="2023-02-22" version="1">MGNLFGRSKSRAAKESKVSSTDRAILQIKQQRDKVKKYQKRLTAQINNEVELIRKLVQQGQKQKALLLLKKKKYTEKVLEKTDNELMTIENLIMDIEYKNVEQNVLKGIEVGNEALKKLNAVFSIEKIEALLEETEEGIEKQQEINELITGIKVENELPDDDEELNEELENILGQRENPIELPEVPGEDLPEIEKPEKIKAAANEKRERLLVEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1P6</accession>
    <name>A0A922L1P6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012412</name>
        <name evidence="2" type="ORF">DERF_012416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1P6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="81" mass="9658" checksum="8F7B698E9757F72C" modified="2023-02-22" version="1">MSMILAFMSPRLRALVHYCKKTDLPKFMDVKHISLRLNGTRDKHAYPSDTRRLEEMTELGLDEKFLDSFYKTYKLKRTMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3F1</accession>
    <name>A0A922L3F1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3F1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7700" checksum="4475DCBAF096A72A" modified="2023-02-22" version="1">MAIIVTRQSESQNHKSRNINHLTRPVTDAVSWNTLPELVDNVSNKRQSNLAKKNCDPPCSYHQTAIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3K7</accession>
    <name>A0A922L3K7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RMI1</name>
        <name evidence="5" type="ORF">DERF_007383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3K7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="4">
        <location>
            <begin position="77"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9516656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="244" mass="28563" checksum="F27141A4827F7089" modified="2023-02-22" version="1">MFPSGNLQQLKSFFHENHAKVKSEWFEQKLGLNSSSNIPDFNEIFQRWLDEDWKQDSQWCLQVLPKELNLSLLNVEKRTFHGHYILQVEKMIDISRPLPTKINVRKSIKDKRKEKQQENEDEKEEKKEKSGTKVKKNGQVKFYGYGRRLWQFCLTDGHQECLAIEYEPLDWLKNPIIGKKVLLSGPFDVYLGTILIKTSNLQLLTANVPKSTLSAIDLQEILEEYDAELEMEALGNQDDTWKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3N0</accession>
    <name>A0A922L3N0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3N0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="1">
        <location>
            <begin position="94"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="373" mass="43469" checksum="1E42B4A4F1D8EA26" modified="2023-02-22" version="1">MANSKQIRRDHFNQELQNLLEQKTKSNLFTKEHHDELIREYIDANRKPATTRSPQEICLLNKFDLLRLEGTKRLVKHGSKFFGTRFFVHSGELFRIFEKAHHELNHASAKKMFDYLRSTYMNITMESITLYIQTCEFCQTKKSLKGIDLRQFSKWLIGFVDMSNSSDGDYRYILKYQDVCTKFCIFKPLKGNDVEQVAENLREIFGWLGAPQILGYEVIVNLLKTKEEESCQNSEWKNEIKKLLTTLCKNRKTDSWAKVIPELQFMLNTIEDHDQCTPFERFLWTKKPSTSFNDSAILSDDSDIHVGNSDSDTDESEETFPNLHRSMSVVVCHCKTGCTTKRCSCLAANSKCSSFCHTQEKYCENRTIIDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L416</accession>
    <name>A0A922L416_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L416"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="156" mass="16790" checksum="BCBCB886F4001623" modified="2023-02-22" version="1">MIRGQAQMGQLAQNVHGGWSASLFQFQDMLNMSVSSVTIVYQEASSSCKTNWMIAMVLNHIGGLAGGGWHQTGGVTGSRSDAQNSELPVLTCILVGTDNNGHRSGGWIEKTTHALISQMVDIVTDCGDDNQYRIRNVGLTMIGDDNDDVGQGKFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L481</accession>
    <name>A0A922L481_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_008349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L481"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000018">
        <property type="entry name" value="Sodium bicarbonate transporter protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000002">
        <property type="entry name" value="Solute carrier family 4 member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF127">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 4 MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="885"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="923"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1005"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1067"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1165"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="11">
        <location>
            <begin position="514"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="11">
        <location>
            <begin position="817"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9517708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1201" mass="135450" checksum="3D5D146FD4CEEE1D" modified="2023-02-22" version="1">MEDNNENKIVSSTSNDGNIDDDQKQEKKEEEQSKPQSLSLSSSSSSSLSLSSLSLTMTKDEELTFIKQPLDEDNDGNNDDIVAQTPSTTTTTTTTTAKTNLEKNLKQTTTKSIKSKLLNTAKMKRKPFISTTKITKTRHTSIENQPPSILIHPANSPEEYHYQHELNPLNLQQQQQQSSKVTIDVGRRRASVTSTQMTTDIATVSSIPDTSRQQQQQQQQTTLSLNPSAARRRKSWDQKVTGPIRRASQALINLSGVLYTGSDNVSSLSTTIFGHNYYGQCSRRDSRSRTQEIILMCSSFQRLPMKDFGAEVRASMDVDQFLQQAVLLLDITETSLEGIVDRMLRKVIDGREPLTTLKEAKTALFTHDSGELQLLARTIQGTYISDGGGFDYDQSWLCSMCSLPSLARRHVAIARLKHPANMGRNSHEVRFFILVVTPSKEKGTKNALETGRTFATIFADIDFRQKLLDVHGEAEFKGILLKHAQDLASEQSNPTRRMGNHEPEAEFEEPRCHFAQGLYDDLRRRTSHYLSDYVDGLVGRKTIQKTISTIFFLYFACILPTIAFGVLNNNNTAGKIDIRKAIIGQTIGGLSFAFLGGQPLVIIMTTAPICLYIKVIYNICEDFQLDFHAMYACVGLWNTFFLVLYAVFDLSKLMKWCTRSTEEIFSLFISIAFAVDAGRDVIKNFQTHYYSPLCLNQLNRTSDRQHLLQHFRQQAQVLAQSNLPLIVESILPSSFSNTTIATTTAATTAIINSDLLSTSTLNYENNSNLNLNNNNPNNNWTDPIYQTAFFLGHSNYSLFSTTNSNSNSNHHHHHQSYNQSVHTNYSSSDIIHLSAANVSTLATTLASLIWSPEANRILQNLTTAALKLIFTDLHMSEDGICRRETSLLFLLLMLGTVWMAVSLFNFNKTPYLQASKRELLADYALPCSVIILSFIGSFVFRDIPVEHFRYDEELHLKRARLEDLPWTAFGACMGLGFSLSLLFFMDQNISAAMVNNPCNKLKKGCAYHLDLFVVGILNGFLSLYAFPWMHGVLPHSPLHVRSLADVEERVDQGHVYEIIVKVRETRLTGIVSHILIGLSVFLIPYPMAYIPTAVLDGLFLYMAITSLNGNQMFERITLLFMEQAAYPPNHYIRRCPQRKIHLFTLCQMVQLGLMCFFGFSPWPYIKMVFPVIVILLLPFRHKIVPFVIDNKYLEALDGENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4M3</accession>
    <name>A0A922L4M3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4M3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="8265" checksum="34853163E22330C9" modified="2023-02-22" version="1">MRKFKYDVIFGSKNKKKDCNSYQLDYHFDMNQTKQKKMMTRTRQIRELKKNKEKNIGYHNNDNDISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4R3</accession>
    <name>A0A922L4R3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="11">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_008427</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homooctamer; active form. Homohexamer; low activity form.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="11"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4R3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025861"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9517796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="364" mass="41060" checksum="253CBA4DA02B67F6" modified="2023-02-22" version="1">MSQMSSTMNENNNNNNKESHYNTSLKDYLHSSQSHPITRHWQSQSVQNFSPKDFILPLFVLDDDYANESIESFPDVYRMGQNILIEYLTPLVSDLGLSSILLFPCLEQQYGQQEEKNLDDAFNVEKNPLLKVIPVIKKKFPQLLIITDVCLCAFTDHGHCCIFDQHNGHIDNPKSIEALAKLSVKYAQVGADVIAPSDMMDSRIALIREQLTLAGYSHVSILSYGAKFSSCFYGPFRNAAGSAPKFGDRKKYQLPAGSRGMALRSIDRDIRQGADMIMVKPAMAYLDIVRSIADHYPNYPIAVYQVSGEYSMLKHAAQIDLFDLRQIVMETIIGFKRAGASIIITYFTADILHWIHNNNGGQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5J0</accession>
    <name>A0A922L5J0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5J0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="30" mass="3336" checksum="813FD95D14ADD9F9" modified="2023-02-22" version="1">MLNPEDICTSVKNHTVTKFFGLVSKLDLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L609</accession>
    <name>A0A922L609_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">AP-1 complex subunit mu-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">AP1M1</name>
        <name evidence="14" type="ORF">DERF_005273</name>
        <name evidence="13" type="ORF">HUG17_3678</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L609"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031984">
        <property type="term" value="C:organelle subcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09258">
        <property type="entry name" value="AP-1_Mu1A_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000002">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="12">
        <location>
            <begin position="167"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7639645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9521636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="424" mass="48748" checksum="D73F7EA1B68D14A8" modified="2023-02-22" version="1">MSASAIYFLDLKGKVLISRNYRGDTDMNIIDKFMALVVEREEESSLNPIIRYQDATFMYIKFNNLYIVVTTKKNANVALVFSFLHKIVAVFSEYFKELEEESIRDNFVLIYELLDEMMDFGYPQITDGKILQEYITQESHKMEIAPKVPMAVTNAVSWRTEGIRYRKNEVFLDVIESVNLLANASQAILNSEIIGSIKMRVYLSGMPELRLGLNDKVLFESTGRGKSKSVELEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTASSVKPLIWIESNIDRHAHSRVEIMVKAKSQFKRRSTANNVEIIIPVPADADSPKFKTSIGTVRYTPEVNSMVWTIKSFPGGKEYLMRAHFGLPSVSGDEIEGRPPIHVKFEIPYFTTSGIQVRYLKIIEKSGYQALPWVRYITQNGDYQLRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6M6</accession>
    <name>A0A922L6M6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Epididymal secretory protein e1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_005496</name>
        <name evidence="7" type="ORF">HUG17_3513</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6M6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="6">
        <location>
            <begin position="9"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7639480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9521874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="154" mass="17215" checksum="657AD079D7E492FC" modified="2023-02-22" version="1">MLTVMLIQFDKCRSCLSPHGQMTSIKTTGCSKQKTFHSNSSVCHLKMGDTVTVRMKFVPNTRVHSLKVRCTGKVHGHSFDVPIPQENVCGNYDNFICPINTGESRDFTIKIPVRYDGPIPSKNMKNVPVTFQLTLEDESHNDVACKKLQAKICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6V1</accession>
    <name>A0A922L6V1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6V1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="221" mass="24864" checksum="DC4B1C047AC6D91F" modified="2023-02-22" version="1">MPQCLSPIDLDTKSPAILEFLHHHHHHHHHNHRVTDDSSNEISSLQNHHYPYHQMFTTIDSPSLDPSMNEFDYFYGQTSNIQTSSTSSSTATITPTIGSCFYPYSKKSLNKTGNRMINRSDLSCHHNHHNRQTPIDDYVYLEFFVDSIKPEYSSSSLSNDLITYQSSSLSPSTASSISTTLDNPPTNFSSSSSSSSSPLSNGTHICLIVDEYSVRIFMVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7C5</accession>
    <name>A0A922L7C5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PTPMT1_1</name>
        <name evidence="5" type="ORF">DERF_005642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7C5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042165">
        <property type="entry name" value="PTPMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712:SF1">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="153"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9522038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="238" mass="28012" checksum="D8E12B49A4DACC45" modified="2023-02-22" version="1">MSIFAKATFIPSLAYNLIRNRWSSWNWFDRIDNRVILGALPFHGAVTNQLYNGENVRAVISMNENFELLFAVTNHYEWRLLNVRYLQLNTADIFHAPTLKQLIDGVEFIMMANDINIDKTKLKSESFQEQKSIQKILYNHKPLLVNWPIKNNKRIIDVIDNNDVTNIPPTTYIHCKAGRTRSATLVACYLIKQYNQTPAEAVKELRKFRHQILLHRKQMQALDQFYAYLLDMKKQNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7H1</accession>
    <name>A0A922L7H1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7H1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="75" mass="7748" checksum="6B78D6D84239C882" modified="2023-02-22" version="1">MKAKRLSGDFSSQMARANVSSLLTQLGLTSPSTGSSTTSPSLSPSSSSGSMAATVTASKVPIGPMFVFTRILWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7L8</accession>
    <name>A0A922L7L8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Der f 1 allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_007090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7L8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="8">
        <location>
            <begin position="31"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="114"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="8">
        <location>
            <begin position="364"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="443"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9516342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="73965" checksum="746FE435C24B0407" modified="2023-02-22" version="1">MINKSINIHYQLIEKNKTVTVYARPASIKTFEEFKKAFNKNYATVEEEEVARKNFLESLKYVEANKGAINHLSDLSLDEFKNRYLMSAEAFEQLKTQFDLNAETSACRINSVNVPSELDLRSLRTVTPIRMQGGCGSCWAFSGVAATESAYLAYRNTSLDLSEQELVDCASQHGCHGDTIPRGIEYIQQNGVVEERSYPYVAREQQCRRPNSQHYGISNYCQIYPPDVKQIREALTQTHTAIAVIIGIKDLRAFQHYDGRTIIQHDNGYQPNYHAVNIVGYGSTQGVDYWIVRNSWDTTWGDSGYGYFQAGNNLMMIEQYPYVVIITIGRKTISHFKPTSRVRFPTLLRTYYDDDAIHRSLLHRAFNKQYESVDQEEIARQNFLDSLKFVQTHDNAAINSFSDLSTEEFKAKLMMSDETFEQITAGVIDDDGVRGCEITQKNVPASLDLLSMGYVTSVKSQGPCGSCWAFSCIASVESAYLATKNQSLNLSVQNLMNCASTHGCHGEAPPTAFKYLQKTGVVDAKVYPYFPRRAMSLTLLRTFNTLSYQRFLSHISGNLKQILAQNHTAISVIIGIKDLSAFRHYNGNSIMREDNGSQVTYHAVNVVGYGSENGVDYWNVKNSWGQSWGQKGFFRMEMNKDLMGIADWAYVVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8X5</accession>
    <name>A0A922L8X5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vinexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SORBS3</name>
        <name evidence="5" type="ORF">DERF_005675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAH9522072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SH3_Sorbs_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3 Domains"/>
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        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_1"/>
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        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3DOMAIN"/>
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
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        <location>
            <begin position="2232"/>
            <end position="2293"/>
        </location>
    </feature>
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            <end position="2604"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
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        </source>
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    <evidence type="ECO:0000313" key="5">
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    <sequence length="2604" mass="290800" checksum="A4931D6B59F16EC0" modified="2023-02-22" version="1">MSSSSTFVSKTTTMIPTLIGSNLLSSSMNIDNNNFEKRKMAKIKPMKQQQQQQPHQQQIKTNSKESKGYFDIIDDIDEADSFVNITAEEPLPDILRSSSTSPSSSCASSLSLLSITTHQSAIIARNGPLNSTDNESSDDHDYIVIHRSATNNVVHEEEDSIDLDDKSPPLPPRNQSKQSDSIVDYFMNRINHNSDDDDNDDIVDGDNDEDHVDNERYHIVYDFPVQYWWHLYPIPEEDEPNTSIEIDAPQTPNTLVNGFDSHGPTIHDDNLMHDIISLDCEQSLVADNLNSTIEKNNPEKIIVNNNNNENGSNSPDKDSGLDETKDSNLEGPLHQSEEELLSPNEDFGPESRNAHRKILSMSSHYPYSGGFVHHHPPPQHLFYDPSTPPFAFYHPHEQFHHHPPPPPPSYHLHHPGSVIDPDDSTRAIRGDDNSSSYSTTTATTMNDSTSTSTTTTGCLVSHHSLREMQKEAESRTECPALQQSSYTSSITTATTTTNDQTTTSSSCPTCMYSDRSYCHHYCHCGLTGPQAPDHSPLLQRPTAFESNGDVECLNKADFTSDGDIDFDDDDNRIDDPGRQSQRRRLSNHQRRYTRSIRTRSIDGTYRHRHGQEEEQSDDIGQLVLSPDGNGGSASGGSLLTSSGSTTSSPSSLSKVTTIRQRRNKTRSISTRSSSLDPDDDLDRNIDDDDDYTDEDDDDIETVRIRPDTQHQPIDGDQMITTTAATTETATSTTMAKSMSSSSSSKTKNKMDIELLEIRRCNLNNVKCCLKERNDNDNHDIDKQSDENSRHRNEQFKLIDQICRFVGRKFFLQQPKLITFDDGHRHNNNNNHQHSECYFCHQSSCLPRQHRHQLQSSLSSGYHKESLSSSPPPSSSSSSSTTTMSLKLIDGKIDADDYDDDDDQMSLYRYNCCCCCLKINPNYPLYCNNYHIITDNRFWSPSTTTTISSTTAATTTTSSLSTSPSSTSISAATTSRSIADYDDDYDHGHDQRQLLSLHQHRSITGENLDNLKSKAQLLQQQRKQQQQQVDNTLLPQASSKSSLSNGHHHQQHQQQPIKNHLQQHHQQTSSLGTTVQAQDQQVDSSRQPQLQQQQQQTTTCIDGKSLNETATVSFPPPFSSRTYAEFKSSPVSIDPQQTITPPIDYLGTTISTSIASGLSSLTLPRNMAIMDHPSTEQQQQQYHHVADVYEPRQHPVHKYWTLPRSIATGTGLGAEYTTSNMAPTEIERHFPAQQQMKPDVSLSTTIAQKQHYVYETEYYTTGEESVLSPPPPPLPQPMITNGDSEKILPIQKNGSTYAAPIKKPPPPPPLPSSSSTQQQDKTSMIKPEYKQPQQQQPSCESSSIQHRSERYKAFIRDMQNEMQIHIGGDINNNNNNNNNNNGDRRSMFANQSICVKVKQPRFKGTDYHLTIDNKPIQTLQQQQQSNVPIGHIEDYEPGIRNSIFERERQMFYNDIFNYIDSIFAEVLATTAVSANQKLQSKLRKRAQSLSRMSSRSLSSARKRSDSQRYHQQTQRYSESPKLSSRSLPSLMTDQQQQRLLEQTKQQLLATFLEATTTATIKRSGSSSRRGRSRSSSLRRHSTDPTPIGTIRRRRKTSKKRRKLSTDKKDGDDEDNDDDDDDEEEEEEESDDHHRSYDNYDEDDGSGNGPCNSKHKDSHDDEHDGDDEVSDDDDDDDDIHHHENAKHTNGNALSPKENGLIDQQQQQQQSPTTSKMEKKFFYHENCVFNQLTSPPATGINQPTGTNSISGGSGYDSDSSYIIRKNKGKIAPQPASPSVYRAVQRGEDIPFQGLQRTAPMRQLSSGNGSRTKFDQTTDTDSGVDFSLSKKPGGEDWDNLDEWQTQITNDFDYIYETLRSVSTNAAPSKKSNTSNQKKQKSVAFEAVDEVQLIDADESDEFYEEDITMDDDDDDECRAVAEEEAEYAYGGLLRPGSHRPSDKAHSFEHFLNTQPDLINKVARMKDPQDRICVIKSKTRKTRSPQKARMGSAGRTPPIRSGNSGLISDSETESDYLTTTTTKKIFSTDTFTSPPKLSSAVPKSYFHSPNIIIDDPTVAVSVVPATIDPISPVRSTMMMGQQPCGSSTATPDSVGLNVHYRIPGSTVTEEDSSFSSSATPNRSYGRHYIGPCGGPLPGTSLKPVTTVVNTSSNTYSLQRHHYVPQPMSPPVVALDRYDRRPLYTTKATATYSSSSMILMLFIEDFSEIDGFLNHFFASFGFPFLSNQIFSLVLERLEPTGKMARVMYDFQAMARNELAVKKGDLVTIRKQINQQWMEVEDCSSGLVGFVPRTYLDIDETSSPNGVARAKFDFNAKTNVEISFKKGEKLTLLRRVDENWYEGMNERQDVGIFPVSYVEVMKQVANASAIRASLSFLDQQSSSIITATVATSNSSNEKNQEGLETSSSSSLSSMLLLNLPISGANSSLPQHHHHPLTSIQPMASMPQLPTETGSSSGGNSSVVYGHHPHIHNHHHQHAHHESQPPLTGDSSSTTGGGSQIYFSSTRSEPAGSTTSGSGGGGGYSTSNLMHQIRRAPDASRSQPGTNVERFCLPKPKIYRVLYPYQPQQPDELELQYGDLLTVTIQCDDGWFLGRSTLTGKFGTFPGNYVEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9L1</accession>
    <name>A0A922L9L1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_001396</name>
        <name evidence="11" type="ORF">HUG17_4583</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9L1"/>
    <dbReference type="OrthoDB" id="6406599at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7641539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9527378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="147" mass="16826" checksum="81EEFDCF6BA4819A" modified="2023-02-22" version="1">MALKRIRKELEDLKRDPPAQCSAGPVGEDPFHWQATIMGPPDSPYQGGVFFLTIHFPTDYPFKPPKVSFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDRDKYNEFAREWTRKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9T4</accession>
    <name>A0A922L9T4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase-like protein 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">METTL10</name>
        <name evidence="2" type="ORF">DERF_000030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9T4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9525897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="132" mass="15646" checksum="1A764822FDD5B6AA" modified="2023-02-22" version="1">MTANDNDEFINESELGTKQFWDRFYDEELINFNDLGDSGETWFGTRNTRKIIDWVNENHVKNDAICDIGCGNGYVLAQLAQRNFTNLYGLDYSEKAIEFCQKQYNQFNIHFNVVDILNDNFQNDQKFRCHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAC2</accession>
    <name>A0A922LAC2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAC2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8902" checksum="6B9B17BCDD4970B1" modified="2023-02-22" version="1">MIGRCILNISLAGHGTHHHYRRGANDDYWIIQRSQHGRKKTLKSQSFFFKETKFDNNKQLQNFHNEDIFIEKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB47</accession>
    <name>A0A922LB47_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Apoptosis-inducing factor 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">AIFM1</name>
        <name evidence="14" type="ORF">DERF_005329</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>A + NADH + H(+) = AH2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11356"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB47"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029324">
        <property type="entry name" value="AIF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF4">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14721">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01353">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="12">
        <location>
            <begin position="127"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial apoptosis-inducing factor C-terminal" evidence="13">
        <location>
            <begin position="471"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9521695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="590" mass="66722" checksum="17B4CEF96CE8B424" modified="2023-02-22" version="1">MLFRKSWKFITTNAHRNIIHYNHHHHPRHRQLINAHGRTFSTPSPSPPPPPQQHSNINSSLIFKWIAAGSLVIGVPSYLWLYRSKSNTDAKLTNNTNVSQKQEKDIDKSSIDSSLQLIENLPETVPYLIIGGGPSGFSAARTIRGNDPTARVLIITEENHYPYTRTPLTKELWFSGLDDKLSFKQYNGKERSIYFEHEEFYLPLNEFNSASHGGISVVKFHKINRLDVANQQAYLDNGQIIKYDKCIIATGTKPKNLKCFEQASEQQPQIEKKIILYRYPENYQQLNELLPKIKSLTLIGNGFTASELAFSLTERAKKLKSNVQINHIFEQDGVLNEVLPVYLSHWCTDRIKDENVNVISNVRIDDVKMDKDQLSLKLTNGQTLNTDICIVDIGSEPNIDIAKSAGFEIDPINGGLIANSELQIQSNIWAAGDVVSFYDKKHGRRRDCHHDNAIYTGRLAGDNASNGGKPGKPYSHNARFWSDLGADIGFEAIGMIDSKLPTFAMFAKSDPNDDEQYKHERGVLFYLKDKTIVGIILWNIFDVDNMHIARRVLYDGMKAKDLNDVARLFALYPSLTSSSLSAMDVDENSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCV6</accession>
    <name>A0A922LCV6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_004080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCV6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9530262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="527" mass="59287" checksum="F9EAC541515D2BD5" modified="2023-02-22" version="1">MFLHTQMDNQSLHMILLAILWIVTFNSFRLTNTNVNAYQTFELVDYCQRFDANVQFPNENRDDDIFSSGVIIEPPHQPSSSNFDLKSSTIKNKNDDAYNVLRIDADYVGKTVVVDTGYDTSAVRLIVDPENVFRARLRCSILVIPKKPNGLIVTLRKLRVRPGTDWLRISINNSSFTRTFSHIRINSERDSVAYVAHHGVLIEFATKTYLPKEEKVEIELILTSFREADLCDIDEEFDCGSFRCISNHYVCDGYNNCGDGQSDLPPPPPSSQEINTSPPPNSALRRFKLAHMASDSMPVLVPTAPPPPTLGQQTNYGSLGQTFYPSTSAFVAYQPYTITLTSGTNRIGLRPLRQLRRQNSLLNEDVIPEHHTFPLPPSTYPILHPQLFQPPSPESHFTSQPSSQSTTNNDPPPPPYTPHNFGPMLARLLSQTLRNKTADRVAVHIVGDQYISIGDNQEQQPIALVYLRSIGSMDFPDNRKTVRAVTDYIHTNLGIEPSRIRMILQNYSTDMIASGGQLVCDQLQPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDG0</accession>
    <name>A0A922LDG0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDG0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="96" mass="10971" checksum="1E3F7487D67DFC3E" modified="2023-02-22" version="1">MAGNKNRTGFSTASIALDDQTGCGRGFDNDCFSVVSTLLQLRLYIRKVRCPHHWFFSGCRDGFQNNKHNHNNKKYHQSLTHPIKCKKKEKGSSQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HFC0</accession>
    <name>A0A922HFC0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sorting nexin 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SNX13</name>
        <name evidence="7" type="ORF">DERF_015829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HFC0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="99"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="385"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="576"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9491092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1001" mass="116839" checksum="DE60916F4F81DFBB" modified="2023-02-22" version="1">MKPNLSFTIITAVVLFTLIFSFHLILFLSTVIVAALFGVLFFFELNTSNVERDFEIFNRTEPIRFVSCDHHARHHLTTMINKHIHLLSKLELNRKFVNKFEIDNQLNSLLEVIIKNHIHPWSRTISPINEELSTKLYILFHQILTALIGRLRRVNVADMIINKLVDEVTKHKRLYRMTKNQLEYKIHTEQEFVQMFFNIERKSEKNSYSHEKVCQQWLQSFQFLSRICDILQYALYPRESFANQTFRMLTKQILLKLLLLPLIESFSEPDFINSIIISFLKSNCPTTETFILVLQSTDDVDELYSVLQSVDEEIMLMRSKDQDDDEWKMKQQLSSLLYLKKIILSHLKKFDDNTSASPSNSDNSGCSNGERRKCSSNESSRIPISFDTVLRHNVALEYFIEYMTSINSEAYINFYINVQTFKISIEQGLFEIYLTSVNDSVTNEQYQQLQNDVRDTALNIYETYLLQSENSPQSNGSSSQLSLVDRNLCEQLYQTLMSGDSSQWMNDALFDDIFFQVRDLLLHHSDFFPAFCQSKYYRKLLGEPDLLRDSLDDESNSEHNKQRNNISTTSENGQTNGFDIDIIDTGILNLQGKSFIGYLINVERKNGESWTILRRYSEFFSFHQTMVDKCDRYHMNLRSILFLPPKTVLSNRMNENFIQYRRYMLNVYLKKLNYIHGKFQFLRDDIERFIQPGNYYSNISSSSASSSTAKNLLNPIKTIGNVFRNQSENLLDGFQRLSRTLSLQTDLNRTTQHQQQQQQQQQPENKRVFQTNSLGSKSSGQNMLKHNSDSSGDLSSILDLFNDDVDSSQAVDSEENIPLLLLLDEVFDLKSQHFWLRRRIIELFKQIVEVAFSDTINKKMIDHINESTSTANLCVYIDSFKNLFWPDGTLARSSTRKKENCLRRKVAAKALIMTSLSDLRRVVGADTLQSGLISFFELFQNKTLNLRLVFVLIELILKELLPDGNWDPIFIRLYSSFDDDHHSTTDSIDYKWPPYLQEMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HIT8</accession>
    <name>A0A922HIT8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TRAFAC class myosin-kinesin ATPase super</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">unc-54_1</name>
        <name evidence="11" type="ORF">DERF_014607</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HIT8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060972">
        <property type="term" value="P:left/right pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031033">
        <property type="term" value="P:myosin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="10">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="131"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="224"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9493879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="559" mass="63367" checksum="073A0326E829EC45" modified="2023-02-22" version="1">MGKNDPSDDPDPSQYLIVSLEQKRKDQTKPYDGKKMVWVPDTDKCFLLGEIQSTKGDVCTVAVKGDERQVKKDLLQQVNPPKFEKTEDMANLTYLNEASVLHNLRERYNSNIIYRQVKKDLLQQVNPPKYEKCEDMSNLTYLNEASVLHNLKERYENQLIYTYSGLFCVVINPYKRFPIYTNRVVQMYRGRRRTEVPPHLFAISDGAYTDMLSNRENQSMLITGESGAGKTENTKKVITYFATVAASGYKHKFSTGCLITCGLHVLRGSGESGAGKTENTKKVIAYFANVGAHAPKPGEEKKKGNLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPMGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGAINGLKEKLLLSNDIHDYFFVSQGKTDIPNVDDAEEMRLTDDYYFVSQGKTVIEGVDDKAEMMVTDEAFDVLGFSAEEKFDIYRITSAVMHIGQMKFKQRPREEQCEPDGMEEGERVAHLLGLNAADLYKNLSKPRIKVGNEFVTQGRTAAQVSYSIGALAKAMYDRLFKWMVKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HJG7</accession>
    <name>A0A922HJG7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_014738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HJG7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="331"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9494014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="548" mass="65866" checksum="C829860B8E6DD528" modified="2023-02-22" version="1">MKSIYIEFFWNLIHPFIRESHEYLSDRNFGNQLSPFDRQELATLIVLHQKLNRILVDFSTDYFSAIDEFTFTIYRFVSSVIKQTFRKDLGIIETLIESKKFCNYNGLLKYNPLFDDIIRIITTKRPHCQTLFELFQVLKDKYMITIELEYDLFYQKIFTWITRGVLNSSLNESFFIQKSSLDSNTSLDLSKVPQQIDPINAIKIYDTGQLVRKIMQMNSKVKFFDADLFWQNYEKRMELYDITILFRYFLADLANMVFSYIMKETSLKEDSMNFIHHLKAFYLHGNELLWTNFLELKSIEDDGIRKAFNLAIYRTFDDYEAETYMHLISIKERIIENNNHRQSLSAHNSNDIGFKITFRLPSLVKIIITDKVWSKYQSIFIFLQKIKFTRWQLIEYWKRQVLMFKRKNHMNNVDKGGQHKSTQWFLLYSLIRFTGIFYTYVKFCIEYRMDQFFANVKQIADIDNIQRFHMSTLLAIINDLFIKNTFFLNLPKNFNLINRILDLSKQLMITKYDDGHLIDDYNQAIEIFRETMQINKSHSPFNELLMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HL87</accession>
    <name>A0A922HL87_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Caseinolytic peptidase B-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_014174</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HL87"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF93">
        <property type="entry name" value="MITOCHONDRIAL DISAGGREGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="7" id="KW-1053">Target membrane</keyword>
    <keyword evidence="6" id="KW-0800">Toxin</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="309"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="12">
        <location>
            <begin position="512"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="605"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="623"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9493427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="76369" checksum="C35EEC6FEB7E2E9B" modified="2023-02-22" version="1">MRNYWQIFRHRFLMKNFQQIITSSSSSRLLIARQSFALNFPIQRINPRILLASGFVTATAAATAYGLHQLKQIRMAECRSNDHQKRLRPNSIEELELFDAIRANDSVKIDKLLKGNRNLYVNTRHSLGWTPLHLAAILGRTEIVQQLLEAGADPDVIDEFSNAGQIAHEHRLRYYDVLLIREREFSDILANNVSFLGTTALHYACLSSSIETIKVLMRYKANPQLENEFGHKPIDYLDDQDAEIISFIPVMQQYMQEYGDYIEKLKIDERRKFPLELRLKEVIVGQEGAIATVAATIRRKENGWVDSEHPLVFLFLGSSGLGKTELAKQVAKYLHGEKSKQKGFIRIDMSEYQEKHEVSKFIGSPPGYVGHDEGGQLTKALRECPNAVVLFDEVEKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNLASDEIAEYGIQLRRETEELSKAQYSGKIINETETKNLEKVEVSRYFKDRFIRPILKRHFKRDEFLGRINEMVYFLPFSRSELHKLVLRELELWSKRSNERHQIQLSWDSNVIGVLANGYDVHYGARSIKYEVERRVVNKLANAHENGLLRCGAKIHLVVSDDGEDYKLGKVEQSKEQSQQSTKSTSTAEERVNNDDGDDDKKSNKKIEAKLKLLIENPPEMATKSKSRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HM50</accession>
    <name>A0A922HM50_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein krueppel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_013404</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Krueppel is a gap class segmentation protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HM50"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035282">
        <property type="term" value="P:segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000012">
        <property type="entry name" value="RB-associated KRAB zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001954">
        <property type="entry name" value="Zinc finger protein 787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0302">Gap protein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9497412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="463" mass="53744" checksum="B8FAEB70D859A7ED" modified="2023-02-22" version="1">MIVPATSSSLDRENLGEYQQQYNRSAKLSNMNGNNYHHQTSESNDHHNDHYPMIHIEMDELEKLFDNVESKFDSISEHIESLIMNSIRQQQQPFDCQQVEQTPARSNVLSFDHDYFHIDNGDDNTLEFVDQSTISSSKETRDLCINPKDSVITISYDNPNDEIDDDDMNIIQSHSEQQNSSSSNENLITKNLTKNKKFPCPNRSNVLFFDHDYFHIDNGDDNTLEFLDQSTTSSSKETRDLCTNPQDSLITINYDNPNDEIDDDDMNIIQNLSEQQNSLSSNENLIIKNLTRNKQFPCPKCSFGFDTSRNLDNHLKTHQPGNKYLCSFCGNRFKVKSRLIIHRRIHTNERPFKCQECDATFTDNSNLICHRRIHTGERPYKCSHCNATFTQNSNLIRHCLIHTGERPYKCSHCNATFTQSSNLTSHRRIHTGERPYQCSHCNDKFRVKHILNIHIKSKHSDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HM71</accession>
    <name>A0A922HM71_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HM71"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7363" checksum="57E723CF047BD460" modified="2023-02-22" version="1">MLLHQPYFKYIERERKNINAHQFSGKKAKQFRNLTLKSNPSSSSPESLFTICNQQKMPMLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMD7</accession>
    <name>A0A922HMD7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMD7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="10067" checksum="B3D74FBF70B4A39C" modified="2023-02-22" version="1">MLPIIIIKSLSACNEDNNKNRKNNQIISYDNINDTDRYYQRIPCNRRQRQQQQLLQEKQQSATNSIESSFDHHSFFNNWHWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMY0</accession>
    <name>A0A922HMY0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMY0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7628" checksum="86326E6F69F7E7BA" modified="2023-02-22" version="1">MSKSSVSEFEHEPHVDDADELLLLPLSLAKVIDEDEDDEDDRDLLNFCRYKDCESLCQTTIKKIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN24</accession>
    <name>A0A922HN24_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_014758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN24"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08023">
        <property type="entry name" value="GH16_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037433477" description="GH16 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="4">
        <location>
            <begin position="21"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9494040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="464" mass="54411" checksum="66BFEB5F24B1D8EF" modified="2023-02-22" version="1">MIFSHIIRLLSLLWPSIIILADQSSLPSLKQPICRWTTKPYFDNDDNKTKISEWNLVWHDEFDSKITLNNQWTIEHEVSTCTGNWLQQEHCNTNRPENVQIIDGYLMLAARRESYYDHDFTAASMTTNQYFTHGRYEIRASNPIGNFLRTSIFTRNHGESYWHENGQIDIFSYVQGNNIIRGIHYADSTNFYEPVDQSLEAVNITNASSMNDFHLYGVEWNNGSIRFFFDDYYSHKICFCNEKKYLKPFHQLRLQIGVGGIFFHVKNLSEKIHWNCPTLVVDYVRIYQYVDHMNNNDTQIPDCHFNTLLESTTKYDIVLNKICTMTRQLDQTDSSLSDYPSSFKLTNFQFVIILISILIILFVAALIYLIVQMKKFGAKVEHQIDYYSVPPPRNSYTIPEDRDEIYEIPVYDYDALETQLERTIQNTITSKNEYLEIKPATTGQSDPPAYETIISEKSFTIDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNF3</accession>
    <name>A0A922HNF3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNF3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7039" checksum="5DC72B3C261A81DB" modified="2023-02-22" version="1">MGRNNNKKKQKSNNSSSDCGYSIVLTLLSSSTTTTFKSEISKTMANGHQQENGNDIIKSSATIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNT1</accession>
    <name>A0A922HNT1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNT1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7006" checksum="BE260D8A89266FB8" modified="2023-02-22" version="1">MAYSRLNVNSVYDDVVIIDVVILITDTGNKFIGGSTIGKKLYHMFFSPYESNISCYGHLAATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNU1</accession>
    <name>A0A922HNU1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isoamyl acetate-hydrolyzing esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IAH1_2</name>
        <name evidence="2" type="ORF">DERF_013114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNU1"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="250" mass="28823" checksum="FAB7C9D7D4E04769" modified="2023-02-22" version="1">MIKHTLKMWPKIILFGDSHTQRSFDPNNGCWGALLANKFQRVCDIIPRGFSGYNTRWCRIIMPKIFQQFKAEEIACVTILLGSNDSVPVSSVTGQHVPVDEYRTNMVAMINFLTSIGIDKNKIILIAPPNMHQDSFKRWSIEQNRPIIPETWEKDLVKYVDACRSIATEMNLSLLDLYTVFMAVKNDNDKLFNDGLHLSRDGGQLLYDNLLPLIMERVVRITGKPFTDQSMQYPYWRDVNTDDPEKSLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPA8</accession>
    <name>A0A922HPA8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanyl-nucleotide exchange factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BCAR3</name>
        <name evidence="5" type="ORF">DERF_013024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPA8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055491">
        <property type="entry name" value="DUF7063"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051853">
        <property type="entry name" value="SH2-Ras-GEF_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247">
        <property type="entry name" value="BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14247:SF8">
        <property type="entry name" value="RAS-GEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23205">
        <property type="entry name" value="DUF7063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="146"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9497006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="268" mass="31257" checksum="A5BB074EFCB02E69" modified="2023-02-22" version="1">MLWPNIENLGYYHGRLNRLEAEKLLAHDGQFLLRYTVQQVNNNEQKLLVLSCQHGNQHLHFIIHEIIIDGIGCRRFYFENESFTTVSDLISYHVINRIPITIESGAIIIEPIEYRLDCRMITAIRLDDSNDDQTTTSVVNVLLEHDAEFLAKYLLKTNIRFIMSKCKIVGINESMCSGLELMLLPEGSQLRKDLIIRHECLKYFVITTILKQSDQSKQLELIRKWMDIANQLENSIHDHFGFGSIMFGLCFPRIQDSTMWKIFGQKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPJ2</accession>
    <name>A0A922HPJ2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">DNA mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MLH1</name>
        <name evidence="9" type="ORF">DERF_012193</name>
        <name evidence="8" type="ORF">HUG17_8967</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPJ2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair endonuclease MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="223"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7637863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9501340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="718" mass="81891" checksum="BFA15867D6CF6F0B" modified="2023-02-22" version="1">MADQKSSLRLINKLDNDLVKKICAGEAIHRPLNVVKELIENSLDAGSTMITVTLKDGGLDQIQIQDNGCGINKEDLKIVCDRFTTSKLKSLDDFNSLSTFGFRGEALASIAVAAQVTIISKTADSICAYKAEYVDGHLKNSSAPIVPIAANDGTMIQVDNLFYNMPTRKAALSSENQEYNFVQDLIVRYSLIFSGKCGFIFKKYNENSHVVNTKSSATLFQNIDQIFGKKISSNLLSFDIENEKLEFKIHGYFTKQNISLKQFTFILAINSRLVECETLKKSIKDLYKEFLMTDGHPFVIIWIEINPKNIDVNIHPNKNEVCFLHDDEIISKIIEFIREKLENKLDNDMIKNTSSTNMDISFIRNQTNDKKPIDNENSAGTSKISTLKLKLSDAAKQTNSPSQTIDNYQKSSQTLPVDEKCEDVPVKEIETLPRPASKPKSSNPNRICRIDSTIQRIQSYLQQEVSELGPRRRRRIELTSLDKLMKDLSSTIDLNLVEMLNESIYVGCLDENFLLIQHELDLIMLNMPKLNRELFYQIYLMGFGNFDYFRFKQPLSIRTLLSTYFEVNAPDMDPDVSTATIETMVKTIVCKKEMLDDYFSIRINKDDATIESLPVMIAKYEPNYIYLPEFIHGLATNIDWNHEKECFGTLGQELAKFYSYAPSISNTNDAEFRVWSDLVETQIYPRYKKLLSPTNQLSDGAIYVIANVTELYKVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ93</accession>
    <name>A0A922HQ93_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Forkhead box protein K2, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FOXK2_1</name>
        <name evidence="10" type="ORF">DERF_012804</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ93"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22688">
        <property type="entry name" value="FHA_FOXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF7">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="187"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="566"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="566"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="416"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="989"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="989"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9502002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1130" mass="122250" checksum="8FF06D5E8BDC1B72" modified="2023-02-22" version="1">MPIAILTNNSDQQKQQQQQQPIDSTDNLTISAIKTMAETATVAATTTTTTNNSSSQSSSIKYEIANDNRHNNNNDRSSSPSSINNNNNSGSGNNNHLATNISASDAYDAHVLLSLRSAPASPSSIQPSANWPLIMKNDNLVSGQKLLLKNNNNGQQQQHHQQQQPRQIPMAKLEARGFEYLIRGNRTIIGRDSSRGKVDVNMGHSNFISRRHLEIHFEPPSSNFFLTCKGKNGVFIDGVFQRRGSPPYKLPPTCVFRFPSTNIRLEFQSLIESKHHHYPMDKDGLSSSDDLNQNKSMMLMASNRMNDVINNSNGNQSSKYFSPLKVNIPEIATNTSNNSDFVSPIPSPTGTISAANSCPASPRSNSVRFRFGNNNSNHHLTSSSTNNNNNQNQIHKPEEFHKMVAYAAAAAMSCKEESSNNNSNQELIISNNNNNSNESQQQQPQIKNIKVFQITPSLQQQQQQQQQYAQQHGTPIIASISNNSAHQSIIINHHTNGSNFIKTQNGQALLTTTGTTTLTSSKSTSLQNNANDKHQTTIHTPSQSPPHYSIEIGSNSGSGGADDDGKPPYSYAQLIVQAIASAPDKQLTLSGIYTFITKNYPYYRTAEKGWQYHDHNPNLGKGSFWRIDPSSENKLIEQAFKRRRQRPNSGIGDQPSGQSSGRGNHPSRSAPTSPSHQGGGGHYVSGLVTPDSLSREPSPSPTHQENIESEIISTGFNVGSIVTPAYLTIPNADNFLIINNNNNKIYSSRSAPGSPGSISEENINNEQVISQQQQQQQLLPPSTMVTTMTNNNNETFPLNPHQQQLTLANGTKVILDRSSFSSLSSSSSSSLSTTSSSITSTPATTTFTVVQQQPATIASSSSSANAAATAAAIALTNLQNKFEIHTLQQQQQQQPNQQPSPSTTPKIIQQPTVIVQAPSNNTNNNLPLTTEQLNLSRVVICQPQSLSSFNTSSSLSSLSTTSTTAGMMNIIKPTTALITANVNNSNNNSISNSQLHPLSLTPSSTTTATATTIQMEQKPTVTTTSATATSVSRSAIDLLTSAALAVQQNNDTVVGSSTELSSQSLDDKKPMPVFVVVTSSTSTPSSLSSALTTATTTLTSTTGIKRDLTVKNDDDDETNKRIKLEENVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ97</accession>
    <name>A0A922HQ97_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">VPS8_1</name>
        <name evidence="6" type="ORF">DERF_012539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ97"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="697"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="799"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="809"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9501715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="823" mass="98464" checksum="8B2247273C3D90D0" modified="2023-02-22" version="1">MKSIFIESLESHIFDDQLPSLNPLIVNEMIDYLIGKEWYNLLDSLIVHLDIQSLDIDHIIRIYGQYHLYDSFIYIYTCAMNDFLTPFDELLKLLRDSIQTKSQLLSKTDIIIGNKLLVYLNCMLTCTYYPNKGSLPEMQQQDHLESCFQRLMAVNDDNRLDIIDVLFRYDSIEFLNTLLIGFDYLDSHHSNLCYFKQIVIDKMLAFIVEQNTTDFNDDHRNSFFIFLGRCCISTQSSSHDSIKIIDDHFNQMIDSLFAASSNKRFEERQQILIQLFRNRPWNQRLNAENFLQKAQTSRMYKICEQIYRDRRDWINLFRIHVDDSSKHDEIFNFIDLIITQDDRFFNLQQSTDNWNKSDFLNTVFEQFCFLIQIDHRKSAQLFYQFVEQCDGLFNIIICQLESDPYRHYQFLRQIMVEFNQNNNDESNVVNKPKILEQICNDGKNQDIFLELCLQFEPEKIVSMFQLLKNYDQIKMLEICHESQSYDGQAFLLESMKQYVKSFEVLFDQFRKSLDDIVHMDRFLVNVEDNECAMKNFQKILEFCDRHHDHDKPEMYWLKLLEYLIFIKSGCQQQQQQQISAKQKSSSSSSSSKRREMAGQIELNKILNQLFETLISEMLTHLNLVLFLDIIMEKILKQSDTICDFREMLLCILENYNYEKILLELTTNILSVEHRQLIEQFRRLKFRSKIFRRSMIHCELCDDNENNNNDDDVDDGEKFVTFHNCDHIVHWTCLQRYTNNQTNNCPFCHHIIQQQTSRNYDKTFSKHQKNQNNHQPIFNDIQLRILNQIHHGRLKSLMIHKQRQHHRSSPSKSNNSRTILSPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQR1</accession>
    <name>A0A922HQR1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhomboid- protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RHBDL3_2</name>
        <name evidence="2" type="ORF">DERF_013215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQR1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="106" mass="12731" checksum="67BF929DCB8A5D3D" modified="2023-02-22" version="1">MFVRKKKLSKEKIFTKKNAKWIRLFEKFDPEGAGRISTEDFLIAIDSKDFRQDPRVARKRAALKSKVLEYGTSFITIEEFIEVCYINRRYGYTIFCDWHIVDQHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQZ5</accession>
    <name>A0A922HQZ5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CLCN7</name>
        <name evidence="14" type="ORF">DERF_013815</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQZ5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF136">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9 11" id="KW-0868">Chloride</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="726"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="838"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9497861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="895" mass="100154" checksum="068DA4FF21C29315" modified="2023-02-22" version="1">MSSSSSSSSNSTNNNLPSTSSTLIEQQQQQQQQQQEPGLGSDAEISLPMTPEPPDSTTRENEEVVEIIEPIPAFLDSTSPNRRYRPRSISHLPYKRNSERRLQKFRDKQKFRSTLNRTVSTESLINHDANNDTDDHNNDQDLNATNHPHHTHHNVQNGDANKTITSVVSMTSTISQSVSRRMYHQKSLGYESLDYDICENMLHLEEENNARRKGLGNHYLEFTRWLVIFFIGVLIGLTACCILYSVETLTNYKYQKLMNLLNSSNPNSMIKPYIIWLLTNGIPVFLGSWLVTYMAPVAAGSGIPVIKCYLNGVKVPEVVRVKTYFAKMFGVICSVVGGLACGKEGPMIHCGATIAAGISQAKSTTFNLNFEIGLSRFREDHEKRDFVSAGAAAGVAAAFGSPLGGVLFALEEGASFWNQQLVLRIFFCSLVSSFTLNSVVSVFNGERMGSPGLLNFGKFQDIDYSFYEIPLFAAMGVFGGITGALFNLFNMKLTILRQRWLENRRLLRVAEAVFVSLLTATIGFALMNVWSECTPETTEETQFPVTYGCQKGQHNVMAALWFNTPEATLKNLFHNKDGAWNIRSLTIFVITYFFISCVTYGLSVSSGLFIPGLMLGATWGRLVGIGLSYALPNETWIHSGKFALIGASASLGGIVRMTISLTVILIETTGNLSFGLPIMITVFTAKWVGDCFNEGIYDIHIDLSNVPFLGWQPPSDSSRIFASEVMHSPVTSLQVREKVRNVVQILSSTHYNGFPVVDENTIHQAVRTFGRYRGLLLRSQLLVMLKAKIFQEYSLDAPWKNLNSLFRNSYPRYPNLQQIMNELTTDELEMTMDLRPVMNPSAYTISHAASLNRIFRLFRALGLRHIVVLNDYNEVIGIVTRKDLAFYCTVRFDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRZ7</accession>
    <name>A0A922HRZ7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_011324</name>
        <name evidence="2" type="ORF">HUG17_7091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRZ7"/>
    <dbReference type="OrthoDB" id="10333156at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20379">
        <property type="entry name" value="Tudor_dTUD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16442:SF1">
        <property type="entry name" value="RING FINGER PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="271"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7636885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="448" mass="52165" checksum="8467970F1938CAF7" modified="2023-02-22" version="1">MLSELNLSCLFQETIPESPNPDDQKIPCVITKYLNYNEIFVQFKKYRDSFAQLSSDMHAYYCVKSWNEMVFIEKASNEQLIKNLFIYHDHHYDLYLRAKILDLFAGRKYRVLFLDLGYEYIADKNDLILNDNPEFLKLPIQGFQFGLRLDDADYQMIEHHPEKSEFNLAVQKIVLSSSDFWISFSKNMDQCKVNVFCKHHDQIIDLAKFIKSKINSKTEMVVTKNGATNSNVKSSEKGIDGHLSESIISSSSIMIVHPLLWESYAQFVMKVKQVTSPNDFYLKFIADPDYQKFKAKLQSYMTSNSIQRISAPKIGHVYGAIADHHRNKYIRVFILSFDDKTNEYNCFEMDKGMDAFYKSTHLYKIPEDLATFPARSVRASLYGVVPKNNEEWNMETTMELQQKICEQKAEVITMEFNHEKHFLKCSLIVDDINVGDYLIENGYADIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS21</accession>
    <name>A0A922HS21_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Smoothelin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_012529</name>
        <name evidence="5" type="ORF">HUG17_8872</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the smoothelin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS21"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000009">
        <property type="entry name" value="smoothelin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF88">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7637768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9501703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="106" mass="12457" checksum="525282DED0FA3A4B" modified="2023-02-22" version="1">MLLRWSKAKTRGYEHVNIENFSSSWANGMAFCALIHHFFPDSFEYDKLDPNNRRENLTIAFNTIQDKIDVPPMIEVDDMLAAKDKPDPKCVFTYMQAVYRKLHDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS54</accession>
    <name>A0A922HS54_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS54"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7022" checksum="2D1949FA8ECC26A0" modified="2023-02-22" version="1">MINYKQETVYLNVNIKLGQTKKRNAKCNNHIELQSPIIDQIDHNISISSCKNLKLVCGGLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSD5</accession>
    <name>A0A922HSD5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_012692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSD5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9501883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="273" mass="29811" checksum="5470FE647643BF87" modified="2023-02-22" version="1">MAAQILNSLGRLGIGLAIGASVLNTSLYNVDGGSRAVIFDRFAGIKKNVVGEGTHFLIPWVQRAIIYDIRSRPKSVSVITGSKDLQTVNITLRILFRPIPSELPKLYSSLGEDYDQRVLPSITNEVLKAVVAQFDAGELITQREIVSSRVSEDLTERASHFGLVLDDISLTHLGFGREFTAAVEMKQVAQQDAERARFVVEKAEHLKKAAVISAEGDSQAASLLAKAFGDCGEALVELRRMEAAEEIAKQLSRSRNIAYLPPGQHTLLSLPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSF3</accession>
    <name>A0A922HSF3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RPL18</name>
        <name evidence="9" type="ORF">DERF_011191</name>
        <name evidence="8" type="ORF">HUG17_5963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSF3"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021132">
        <property type="entry name" value="Ribosomal_eL18/eL18-A/B/_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01106">
        <property type="entry name" value="RIBOSOMAL_L18E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="7">
        <location>
            <begin position="2"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7643601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9506460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="188" mass="21573" checksum="2550B50DD6A9B7D5" modified="2023-02-22" version="1">MGVDINHKHDRKVRRLAPKSKDPYLLLLVKLYRFLARRSGSKFAKIVLRRLYMSKINRPPLSLRRLVRHMSAEQRQNKIAVIVGTITDDVRLFEVPKMTIACLRCTKRARARILKAGGEIITFDQLAQRAPTGKNTVLLQGPRNAREAVRHFGPAPGVPGSHTKPYVRSRGRKYERARGRRASRAYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSM5</accession>
    <name>A0A922HSM5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSM5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7806" checksum="C06CBF6726ABF089" modified="2023-02-22" version="1">MNSGNHQQTKTLRIPPSDVHLHQAKLPMMMIMMMMMITLMTISMPFKFSNNKIRQQQQQQQQCNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSX6</accession>
    <name>A0A922HSX6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RCC1 and BTB domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RCBTB2_15</name>
        <name evidence="5" type="ORF">DERF_012135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSX6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="212"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="262"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="316"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="438"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="703"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="753"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="807"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="927"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9501277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1050" mass="120952" checksum="923656303416E29F" modified="2023-02-22" version="1" fragment="single">LVNNKWRGQTDWQLDGPKNGWKNHIKVHTTQAIITSDHFCWLAVLIYHHHHHHKHFFLIFPTLVFSSSPNESIDIELFQDDFKNIDQEFLQSVVSIFKFGISTENSFMEEFLLMTKEATFAYGEQICSWLSLEHDMSKPQRISLLNDVKIVQVDFGWGFVAILTDDGKVFIASKVKSNWKTNKTLRLINTGNDKFKMIACGRWHLLLLRQDGHVFSMGNNSHGQIAGNERLSYDSMIQIKKLENVKLIACGFDHNLSITNKEETYSWGGNSFGQLGLGDEKDRKTPRLVAFPNVDSTRIKDIVAGIFFSLFLFENGQLWACGSNYNGVLGLGETKIRSTPTKIPIENVKQIACSKVDSFLLANDGSSYYAWGKAKYRKWSSPKRFDDHPTSFVAASAMIFPSPLTFGLTSTIYVFGSHDSISYQSKSILQLFDNQDSYDVEFLIDQKPIKACKCYLESISEYYRRMFSGNWSENDQVTINDYQYDTYYAFLRMLHTGEIHINHQNIIELVDLANCYGDLKLMEHCETFIRNDLNAQTMTTYLPLIIKYELKILEYKFRNIARPPAEKIDIDLFEEDFEDIHQEFLQSVVSIFSFSFNVEKQFLLMTKEATYAYGVEICTWLSLEHKWSEPQRISLLDDMKIVQVDYGRNFIAILTDNGQVFLASDEETKWKTNKTLQLINTGTDRFKMISCGKLHLLLLRQDGHVFAMGDNSRGQITGNKKSSYESMIDIDNLENTELIACGWFHSLSITNNGEIYSWGHNDFGQLGLGDENKRNAPCLVSYPIADSTLIKDIVAGDRHSLFLFENGQLWGCGSNSDGELGLGDDIKQLVLTKIPIENVQQIVCSKFHSFSLAYDGSSYYAWGKIIYSKLLSPRELDDSHSSFASASVQVLNPFTFCLTSIIHEFKLHDPISYQCKSIQLFNNQDSYDMEFIIDGKRIKVCKCYLKSVSKFYGDKFSDDWKEKKEVTINEYSYDAYYEYLRMLHTGKIYINRQNITELVGMANCYGVERLMKYCETFIQNDLNKQTMLTYVPLINKYQEFYAKLVHLDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTQ4</accession>
    <name>A0A922HTQ4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytohesin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CYTH1</name>
        <name evidence="5" type="ORF">DERF_009303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTQ4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01252">
        <property type="entry name" value="PH_GRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF402">
        <property type="entry name" value="MIP16918P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="4">
        <location>
            <begin position="121"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="315"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9510797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="448" mass="51189" checksum="54407E9ACD480C4B" modified="2023-02-22" version="1">MAATTTANDNGNGISLSPSSSTPAVGAIIGNNGGVNNNNNNNGTFLCDISNLTAEERNKLDEIRQKRQKLLNEIQKLKEEISLVKKEMSRLDHHPLQQQQPQQYPQSNSIIDGSSNDHVNNNNGNQQRLKQLSIGKKKFNMDPKKGNTPEDVAIFLYKGESLNKTAIGTYLGEKIDFNLKVLNHFIELHDFKDSLLVQALRQFLWSFRLPGEAQKIDRMMEKFAAHYCHQNPGVFSNTDTCFVLSFSIIMLNTSLHNPNVKDKMTADKFIQMNRGINNGGDLSKELLLSLYENIRHEPFKIPEDDGQELMHTFFNPDREGWLWKQGGRYKSWKRRWFLLNDKCLYYFECDTDKEPRGIIPLENVDIREIGDRGGRQHCFELYSPISDVIKACKTDTEGRVIEGRHSVYRLSAATAAEKDAWVKSIQTSVSRNPFYEMLAARKRKAQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV60</accession>
    <name>A0A922HV60_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV60"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9507049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="182" mass="20536" checksum="A611BAFC1040A604" modified="2023-02-22" version="1">MKKNSVDLPVWYSKNSTNNNPNDDSINKKSSSSSLIIHCVKKIHHEIFFSGSNETKTMVVPNYCLVINSDDDDDDDDNVDDHTTTTCQECANNRTGIIESPRKAVIPGYNLQISGFYDYLNKWNRLINSHDSQDSQPCGHRITLIRDALESGVGLHVLIGLMFISEWVESELNSDCERELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVJ3</accession>
    <name>A0A922HVJ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_011775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVJ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9507072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="430" mass="50287" checksum="D75C14390709B353" modified="2023-02-22" version="1">MKILFHPIESWGHMNATIGVAQIMLKCGHQIIFAVTENVRGQFRKHGFQEIILKTEPITPPPPLDRQTDCVDFLMNSTDVFWEKEPLKKYSMFQKVFEIRVEEILQTEQQMKEILHDEKPDLILVDQILISPIIIRSGIPWVLIFSCNPISFHNDQRLPPPFSGLPIDDQSLWSKYRQEFKQTYHHYVISNQNFLMKHYGYEPLTYDGISPPSPYLNIYGFPEELDYNNIAPMPNNCFRIDTFCRSENEELNISKEFLHNHRDNKLIYISLGTLASIRFDLIKKILMILSQTKYGFIVSKGRFDDGFKLPDNMFGAKHLPQTKVLPLVDLVITHGGNNTVTESLLFGKPMIVMPFFADQYDNAQRLQENGYGARLDPFNYRQEDLINLVERLLNDQQLKQRLMVMAKRMQTSNLRDELAKRLERLVEMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW25</accession>
    <name>A0A922HW25_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 15">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TOP2B_11</name>
        <name evidence="20" type="ORF">DERF_009117</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 15"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12 14 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 14 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14 15" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="18">
        <location>
            <begin position="444"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="19">
        <location>
            <begin position="704"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1087"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1297"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1127"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1087"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1101"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1302"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="14">
        <location>
            <position position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH9510596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1344" mass="156688" checksum="2D94AC22B2507D31" modified="2023-02-22" version="1">MDDNRPPLKALSSQKRDIEQIYQKKSQIEQVLLHPRKFIGSTNRKIKQMWVYDGQHGMVLRDISFVPGLYKIFDEILVNVGHKIKKDLNMNLIRIDINSEDNEISVYNNGRGIPVVIHEEEKIYVPTLFFGHLLASSNYNDNGKKIVGGRNDYGAKLCNIFSTMFKIETSSREYNKCFSQTWKDNMQTAEEPIIRPSEGDDYTRVTFKPDLKKFNMTHLDKDIVDLFSRRAYDIAGSSNEINVILNGERLHVKGFQSYINMFIRDNEDKNNKQLKLAHEILSDRWEIALALSDKGFQQISFVNTIATTNGGKHVEHVTNLIMDHLIETVKRKSGKSKINLEPNQIRKHMWVFVNCYIDNPIFDSEMKQKLTSQIKKNVGSKCSPSENFFTSITKIGIVDSILSWIRFKQTEIEKKSSWKKCSKLKNIPKLEDAIYAGTRKSLKCTLILTEGDSAKSLVIAGLSAIGRKKFGVFPLKGKFLNVRQANNNQIQQNREITNLVKILGLQYKKKYTTTEDLKTLRYGKLMLMCDQDLDGCHITGLVINFIQLYWPSLFKLNFIEQFITPIVKASKGSFKRAFYSLPEFEEWKQETSNYKSYKIKYYKGLGTSTSEEAKEYFSDMKRHRIKFRYDDEDDDRAVELAFSKKMIEARKEWLTKGMEERRRRRDNGEKEIYLYEQNTREVTYKDFINKELILFSNMDNERSIPSSVDGFKPGQRKVTYTCFKRNDKREVKVAQLAGSVGELSAYHHGEMSLMSTIINLAQNFVGSNNINLLQPLGQFGTRLQGGKDAASPRYIFTCLSPLARKLFPPLDDPLLAYQYDDNLRIEPEYYVPIIPMVLVNGAEGIGTGWSTKVPNYDPRAIVDNIKRMLRNEEPLEMNPWYKDFRGTVVKVEPMKYVINGEVAILDEQTIEITELPIRTWTQVYKESVLDPMLNDTEQSPALIDDYKEYYTDTTVKFVVKMNKNAWEKVMRDGIHKEFKLQSSMSISSMVLFDTNGVIRRYESPLDILREFFTFRLDFYVRRKRYYEGMLEAEALKLENQVRFILEKNDQKIIMENIERKEFLKILIERKYDSDPVKACRKEFNIDQNEPDTTLNNKNGDIENDDEIPETEEEEKYDFDYLIEMTMLTMFKEEVQELFKKLDAKKSELEELKRSTPEMLWEKDLDAFLEELERLEKDERENALNSNMDDIYKPSALSYRIEPIIEVENNQSENERVKKSINNKKEMRKIVVATTSTTSTINEKRKSDEFVGKSKKTIANKKQKTIMLSSDDDDNSSQLLAVSTPKQPSLRVRKVINYKEYTNEESDVNEESDVNEESDYNSQDNDDTDESDDNFPDNDDNEEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWM3</accession>
    <name>A0A922HWM3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myblike DNAbinding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SNAPC4</name>
        <name evidence="9" type="ORF">DERF_011716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWM3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="240"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="363"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="918"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="542"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="933"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9507013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="992" mass="118045" checksum="0EEBDF5FA6581D9A" modified="2023-02-22" version="1">MDPNETSSNQSENYVHNENEEEDDDDDDEEIRKIKIALEMNQMLTEQFKWKRQKIQQLQDLDFRDNEYDDDDDNDDESSTNSVRNLTHLEKRNSTMFLTKFYKPYLRDDRGFSAPNLFNPEHEYVLDTRIQMCLHHQCPVRNWKTSEIKIIRNEVQSQNLFKQTRSIVKRIEELLVLKARTAEQTEEVNRLNSELAMKRLSQEEPERFCPQIDWLAIAKLCENEDRNENDYELYYNNYLHSSVNRNEWTEDEDVRLKELIEKYGENNWDQVAAELSVTGSHRLAWQCCSRYQSRHSKSMHMTGPIEGEEAEKLSHLIELARTNAGEVDWKYVFRVHEGRRISQIKHFNNQQLLESSNWKRWKRWTQLEDTIIFAAHKYYQNYIEKNEGIYVKIAQHLPNRTNRQIRERYTMILSQQRQQRGDWKLNDDMKLMLACADDLRVDGKIDYIRLNRNHFPYRNAHQLFHRVRLLTRYIPSNFFQQQPINEKQLMECLQTVKTKRLSWKQISQPKLPKNSMKLLNYIRKLSDIQQMIIDGKHNPDGQNDDENSTSGDNDNDDNDNDDNDDDDDDDDDDDDDDDDDDDDVEQTTTTMNLPTALTVLTRPNDDNCEQQWTIDSCIQLYKHLKPLANFFQRRCIYDSNSDLHCADMIRTVLRELLDPDISNDITEVTPSVDYDQTDDYDDGDSVNPSSLDTLRFYLATTSVSINQRQQQQQQQQQFNEIRSLFLPNYSTTYAYVLMQFLYNAMFIHSVENQYQMMNNDDNNDDNVEYQKLRTIFLSLFLWPALLSRLRPDNNCSDERLQQSILRQSSSSSRIDDSNLIGLPDEQQQQQQQQQQLIIKRRGRRPKRKFRHGSLNEFLRTRSIQQKIFLIKNIDNFNQSQSSSSSLPSLWFQRMNFKQLLVEKVSEFLEQISNYVDEELSRRQREKESSTNNKRSRIVRKRRACSIDDDNDNPIQIRRSGRISSRSYNNSSVVVVVDDDDHDDDHHHNNDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWY3</accession>
    <name>A0A922HWY3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">IRAK1</name>
        <name evidence="13" type="ORF">DERF_010396</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWY3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000754">
        <property type="entry name" value="Interleukin-1 receptor-associated kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001">
        <property type="entry name" value="OS01G0253100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27001:SF931">
        <property type="entry name" value="OS11G0664100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="209"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="701"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9511979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="767" mass="87322" checksum="FA650599974F2A00" modified="2023-02-22" version="1">MLYSTQTTNSNYGGYQSQNISNRSPVVYVYELPYNIRKSICDLLDADNSWRELGGLYMGFNDTQLTLISHALYRSASPTNELLTKWESSNAKVSHLFIYLAQMKHHRALHHLLPFILNAKQSTLKNFMGGNSKYYDHHHQNHNRCKNNHQNNCGQSDEEKTLIDLQNDTKKAGLSKRSKSNDQKEIEYLLKIDDFKITYKELVIATDDFSKDNVLGSGGFGTVYIGDWKGTEVAIKKLKGLDNLTQALTELRILNCCRIDNILPLYAVSLDGPEPCLVYQYMSNGSLEDRLLCKGNTVPLTWIQRAKIGEGVARALNFLHTLKGNPFVHGDVKSANILLDPMFEPKLGDFGLARQVVKNSRNENSIYTHCTVSSVNGTSVYLPAEYLRQKILSPAVDVYSYGIVILEMATGRRAYDGKKLLINSVEDEYSKVQNATLQIQSIKSDNNNNQNQKQDSMNENTLEFLMDKRIVNLTDNRHLFNYLLELGRRCAHKTKSKRPIMVQILEYYNQCRATERIYQLCDKVIQNKMSSSKDQLSKTNVKNPIELQLWYDFVRKSCGTLSEVVFENFDAQVTKIIEDLVSSKDSNESTYYLDLLLCSKNRLSNKSLIRSRENPETLSTANNNNNNSSSNESSISSILSSSINTCNQLSNLSINNKTIESNNNDDLSRILKLINLDHNIEQLQQQQQQEHVISKITTMNDEKSSLKNNNNDDDDGQKNLTGEQDDNNDDEQQQLQRHSTPFIPLLTALGFDTTDFDRLIINEQNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXA8</accession>
    <name>A0A922HXA8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXA8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="226" mass="24266" checksum="A849BD2260DED9B8" modified="2023-02-22" version="1">MDPTHDQQQYIQHLQQTIQHLLQTIQHQQQTIQHQQQMIQQLRQQLRRQQQRNNDVDDGQNVAAVVDIDDGQNVAAVADVDDGENVAAVADVEDGQNVAVVADVDDGQNVAAGVDIDDGQNVAAVADVDDDNASSVIEDIDEDSSSLSSLSSAKSVATQIPSLPSATPSPQSSPTPSPQSSPTPSPSPQSSPTPSRPQTRSQTRTQPQPSPTPSRPQTRTRPQPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXQ4</accession>
    <name>A0A922HXQ4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXQ4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9515884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="86" mass="9332" checksum="13576FC1EB7A4EF3" modified="2023-02-22" version="1">MGINLAFDAAKLSRPFLLIFSTNLTICSSSSEVEVASKETHSVVCSFDKAFFHCSSSAHVAAAFASNRWCSHSIEHKKSSNSNFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXU0</accession>
    <name>A0A922HXU0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_010152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXU0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038:SF3">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 20 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="635"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="84"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9511713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="799" mass="90345" checksum="96FB112C3972DCC3" modified="2023-02-22" version="1">MATNDGRIFSEKTTNINSGNTNGDTSMIPMKTFGISVNTESDNLSNVNNGIGNVNKKKTNRPYRLSNFNYNNNNKNTNEDSMMIELIEVNIINGNRTLFESLNFRIDNGQIFGIIGSKKTGKTALLETIATIRSPRTGKVTYYGQTYDQPVRIGFMPQNNGFFTQLTIAENLNLMARLHGLPIEVANIRYESLIDLIGISEAKQPLQQLDQSQQSLIALAMASIHSPSVLVLDEPDFGSDLIQKEQIWHQLKLSCKQEHITVIFSTTQVEDCRYADHAAIVDHRQLYPCRLYQINISDPIASSSRISMDKKSPEMKKKFSAIAMDANHKINEFARHCLSARINSEIVLAETMDQLKKSTDLEPCEPNRYRQVSASTKFMTIFQLLIQLFILKRLSLSLFQLILPTLLAIFCVQLLGQNPHDLRVAVYNPDSPPIVSKHVLNVLDSNTINLIYEDNLDDAIQMVRNGQAWAALEFPANYTNSIFNQALEHCDDLSGDDDEINEILTSVNGSTSTTTVLPESEPETKINMVTILMYVDNTNILIAGFVKAKVLQALERAHHDAKENQVETRMTQPLSVVRPNIYGNDDTPMTDFILPGVIMLAMQFAITILSIYELNELIRSQMFRSSLAMARISRCSLLIIWFLIKFAMLIGQTILFMIILISIMEIRFETSGMTLFITLSIMQSVLILMATIILMLCTSLTTTIVIHWINFIIAITLAGLIFPLECLPPIIHTIMLYSYPWTSIAESMRSAMSRGWSFDHYFEHTQVAEFVWLSINLSAIWILSLLLLFIIILNKNRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ12</accession>
    <name>A0A922HZ12_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ12"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="172" mass="21126" checksum="228C295853619F75" modified="2023-02-22" version="1">MDDSDSVYYSCEDFSDSETISSNDRRKRHYHYQNWRQIKIFNNNEELVEFIGKNWSKWRRNDNEKYLKQYYRCNKVKRKDKQCRARIFTSYDKFSKLIHLYKNNENHNCDKIISTNKRLAKELKNKIISLIEEKQKPKQIYEKLKKEGNVLKQTQVYSVIRRNKLKNIAKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0S7</accession>
    <name>A0A922I0S7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">EH domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">EHD4_2</name>
        <name evidence="14" type="ORF">DERF_008865</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0S7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="38"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="11">
        <location>
            <begin position="426"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="458"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9518274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="514" mass="58819" checksum="20424BAB1E4D99F8" modified="2023-02-22" version="1">MDNVVEGLKRIYKTKILPLEEQYLFHEFHSPPFEDADFDAKPMVLLVGQYSTGKTTFIRYLLERDFPGIRIGPEPTTDRFIAVMYGEQEGIIPGNALVVDPKKQFRPLAKFGNAFLNRLQCSNVTSPILQQITIVDTPGILSGEKQRVDRGYEFTGVLEWFAERVDRIILLFDAHKLDISDEFRRSIEALRGHDDKIRIVLNKADMIDQQQLMRVYGALMWSLGKVLNTPEVARVYIGSFWDQPLQFSQNRKLFEAEEQDLFSDITSLPRNAALRKLNDLIKRARLAKASNALKKEMPSMFGKESKKKELIKNLGNIYLDIEREYGVPSGDFPDLQEMQEKLLHHDFIKFPPLKKPLLDSVDKMLAEDIAKLMSLIPQEQLDHKEETQVKGGAFDSVVESPFGYKRGEGVDAGSMEPSHVWIVDKDKPKYDEIFQSLSPIDNKITGAAAKTELIKSNLPNTILSRIWKLSDLDKDGMLDSEEFALAMHLMQIKLNGHDLPQELPRHLIPPNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1B4</accession>
    <name>A0A922I1B4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1B4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037472156" evidence="1">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9518301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="101" mass="11404" checksum="ABD54376DF1AEAAD" modified="2023-02-22" version="1">MSKNFSISCLAVITFFSLLFVANVDSQNFPNNLFKSCCYYVTIRNCTGKNEVSHLCPDCTRPTPFCGLKSCNIFGCNCDSCRPQKEHTEILGMATWLTEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1C0</accession>
    <name>A0A922I1C0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1C0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="438" mass="49897" checksum="07E34711DB7F4139" modified="2023-02-22" version="1">MATIVNQEMEQPRPSTSKELNHGSMVEIDLSNENKNDVDQSMDGQSEPEPEIVFEPIAETADDDSTENRYCHYLNSIWISINPLFISLARFFRRYINATINWFLYRFGQNGDDDREKIIPDKANVVLSIYDTHFYKIPKAILKQPKQSSNDHCEPNKIASSSSTSSSSDSSVYTTVIGDVKNEIEIHHAEDSSTDQGSLGAKAISILQDALREIRDYDINDNNDQAVVVNDTKKDDDDGDDGDGNKIDAKILIDDQNLQNITAEKKFLLITPITNNDSDVTNELMNLKNWKILFWNDESIMDELDEIILPTTETSLSLYFNYFLYYLLIVISIILIFTAIEMYRIIRYGMFEQNAFGFHYYLDNLDEDEYIFLTPINPLPTVYQNNMPNDDENASPESVEQMNGVIIDPDNNNNNNNMNEGDNGDDGGNEKKIDNNDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I239</accession>
    <name>A0A922I239_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I239"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6938" checksum="A992898BB5BEC5D6" modified="2023-02-22" version="1">MYCAIVHHHQAFKMQKKDDAAPSYSTGKKCNFLMDEKTKPNHSAISLQTINQYPNNKQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2M6</accession>
    <name>A0A922I2M6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2M6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9518329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="36" mass="4135" checksum="110343A85B62E6F8" modified="2023-02-22" version="1">MAIIMNEDDDRAMMNLNRQWPKTNNKPGAVDADDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2V1</accession>
    <name>A0A922I2V1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_007149</name>
        <name evidence="2" type="ORF">HUG17_1608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2V1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7646070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9516410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="80" mass="9164" checksum="96A1DEA4F0B68E9B" modified="2023-02-22" version="1">MSGRLMFVVIMMLALVMALFSIYVNAINDEPDFRDSIRHIPGKLLGNMTKEEMQQFRSTGILPDRINEMISNFTVNAVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I461</accession>
    <name>A0A922I461_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NDUFAB1_1</name>
        <name evidence="17" type="ORF">DERF_005378</name>
        <name evidence="16" type="ORF">HUG17_3588</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I461"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="101"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7639555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9521746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="194" mass="22941" checksum="05F5C9C15DDBCC7A" modified="2023-02-22" version="1">MAQSIRWILRSQPLSQSSLGSQSLMARFWLPIKPNCQQQSLIAPVSSTNIYRYFQTYSLPIMSTWSPYNSHNKQLNKHMDQTKQMIIMPKRNVHKPPLTVDFIRERIMLVLRLYDKIDPDKLTIDSHFYKDLGLDSLDHVEIIMAIEDEFHFEIPDADAEKLNTPRDMLNYIQIKEEVYSELEHHDDHHTEGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4I7</accession>
    <name>A0A922I4I7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sodium/potassium-transporting ATPase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">ATP1A1_3</name>
        <name evidence="23" type="ORF">DERF_005961</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Derf</strain>
            <tissue evidence="23">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Derf</strain>
            <tissue evidence="23">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Cell membrane</location>
            <topology evidence="1 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4I7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02608">
        <property type="entry name" value="P-type_ATPase_Na-K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000003">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000001">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000004">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000095">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005775">
        <property type="entry name" value="P-type_ATPase_IIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01106">
        <property type="entry name" value="ATPase-IIC_X-K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF13">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 20" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 20" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0740">Sodium/potassium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="892"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="931"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="963"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH9522382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1001" mass="110642" checksum="8E4AB8EBC8D70ACD" modified="2023-02-22" version="1">MGNKSSKKDTNLDELKQEVSMDEHRISLGELYSRLGTHPDHGLTPSRAKEVLLRDGPNALTPPKTTPEWVKFCKQLFGGFALLLWIGAFLCFFAYAIQSTSEEEPAPDNLYLGIVLAVVVIITGIFSYYQEAKSSAIMESFKSLVPQYATVVREGQKHTIPAEEVVVGDVVEVKGGDRIPADIRVFKSHGCKVDNSSLTGESEPQTRSPELTSDNPLETRNLAFFSTNCVEGAATGVVINTGDRTIMGRIANLASGLEMGETPIAKEISHFIHIITGVAVFLGVTFFIIAFILGYHWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNHIIEADTTEDQSGVQYDKSSPGWKALSRTASLCSRAEFKANQDNIPILKRECAGDASESAILKCMEIALGNVMDFRRKNQKICEIPFNSTNKYHVTIHDCPETKSYLLCMKGAPERILDRCSTIFINGEEKVLNDELKDAFNTAYLELGGLGERVIGFCDLALPLDKFPKGYPFDADEANFPLDNLRFLGLISMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKAVGIISEGTETVEDIANRLNIPVENVNPRDAKAAVIHGQELKDMTSEEIDEVLRHHSEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEISPFLFFIIFNTPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRDPQHDKLVNERLISVSYGQIGMIQAAAGFFSYFVIMAEHGFWGWMLFGLREKWDSQGVNDLEDAAGQEWTYHARKKLEYTCHTAFFVAIVVVQWADLIICKTRRNSLVHQKMKNHVLNFGLCFETALAAFLSYCPGMPILLRLYPLKFTWWLVPIPFSLLIFVYDEIRRFILRRNPGGWVEKETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4M8</accession>
    <name>A0A922I4M8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase inhibitor 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PI15</name>
        <name evidence="3" type="ORF">DERF_004360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4M8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="49"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="572" mass="65611" checksum="FD84138547A50D69" modified="2023-02-22" version="1">MANVNDGQTTTAQDQSICQTYFAKYTKSHTACVKPNKNCQIKEQGLDKKQRQLILDIHNYYRNLIASGNESTLGFPSAANMLTLEWDDELAYVAQKHANQCRFEHDCYDCRRTERYPVVGQNLYIYRTTRSKADPDWRKVIREWYEEIKIAPPQVAFSFDLFQLNIGHFTQIAWAETNRIGCGFSTYLDYENRGSIFKTVQLYTCNYAPGGNYLGEKMYENGTPLSKCPPQYGKSKNFQALCEFITKWESNIDAFALVDNRIDTNLLSATPIDNNPSTSLSIINNNNNNNQYSTVYNRIESTTATSTTTTTTTQRTTVNTPKSRTTSTRRNGSNRRKNTSNRNGNRNRSGSSRTANNRNNSTRRNSSSSNNFNDKQWNSRLNNWKNNSTTSTTTTTTTTSPSTTSPSTSTASWKWNQSSYDWKKWLTNFTTFTNWTKWESKPQRSIVTSANIGTTGQVDPSIRIVTPRRSTTQGSNNNNNNNNGNQNNNVPWRLTNITWWTNWTTTTNAKPKSTNRITTRLPTYTWSLSLGLQRENESIAPNSWSRSIDLTPNRANSALYYRYNNRYNNNYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4R6</accession>
    <name>A0A922I4R6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_006068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4R6"/>
    <dbReference type="OrthoDB" id="10051670at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF551">
        <property type="entry name" value="RE08073P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9522502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="238" mass="27404" checksum="AA95BC3524A68696" modified="2023-02-22" version="1">MGATHHENLVPLKMGVYATNFMLWSLGIVLMGICIWIRSDSALWAYGDNMDIYRYYQATYICLAISALILVMAFLGCLGAAHEFKYLMFFYCIMSGILIILEIAAAVLVWRIPGGDALQYHLGHEFKWHMEQRLYNTKSRQFLDLIQLKLECCGAETMLDYRKMYQDIPASCNSPRTNNINIRSCAEMLRRYLEKRGGAVGGIVCSLILVEFGSLLFSFLLLRQSEEYKNDMKQYGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5B7</accession>
    <name>A0A922I5B7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5B7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34410">
        <property type="entry name" value="INTRON-ENCODED HOMING ENDONUCLEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34410:SF2">
        <property type="entry name" value="RRNA INTRON-ENCODED HOMING ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="166" mass="18398" checksum="0A5FC082AB728236" modified="2023-02-22" version="1">MRSRNWNEYSLNPLTRINWRASLVPAAAVIPAPIAYIKVVVVKKLVVGSQLMHGGPLDGGYCHAEQNIALSHVLKAGINRLNTVAWNNGIGPWFCSVGLRNRAKAFVKNVFINQERKLEVRRRSDTALVLTINDANQQSARVYCMTRLAASGNQSFSVPGEVWLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5I9</accession>
    <name>A0A922I5I9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutaredoxin 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Glutaredoxin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GLRX3</name>
        <name evidence="7" type="ORF">DERF_006077</name>
        <name evidence="6" type="ORF">HUG17_3082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5I9"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="117"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7639049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9522511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="202" mass="23072" checksum="40C63738BBF21380" modified="2023-02-22" version="1">MEEIEASNLEKTILSSPLVNIIFYAKNDERCSQILDFIPELVAQDEFKKFKFFKIDAVSGTFAVRSVPTMIMFRNGNEIDRVVGADTSAITQKLRKILESDRSIEQRLKSLINQQPIMVFIKGTPEQPRCGFTRTLLLILKQMNVQFGHFDILSDEEVRQSLKAYSKWPTYPQLYVKGALIGGVDIIQDLHENGELENVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5M5</accession>
    <name>A0A922I5M5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Deoxycytidine metabolic process</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TK2_2</name>
        <name evidence="2" type="ORF">DERF_004233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5M5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001571">
        <property type="entry name" value="Deoxynucleoside kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF24">
        <property type="entry name" value="THYMIDINE KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="1">
        <location>
            <begin position="194"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="407" mass="46991" checksum="CEF8E6780AA157EF" modified="2023-02-22" version="1">MMTIHAIRYSLTTTTIWYKHCKNNVEISKKMSKLICMFNKVRMSSTTANIGYNELMPRKFNDVRVCMEAPPSAQQQQHIHKPIKTVMQCFGAKTHYLLSQTIRKRSFCPLSSVLAAFLRSSSTLHDFSHSNRKKSTLISETMEQFIIKSTQSKNNDEDNNESSLISKTLNDNRLFEIPSMCLSYKAEKNKVLKIIVEGNIGSGKTTFLSIFAKNCSKLCNDPLIIPEPVDLWRDVGGVNIFQLLADDPKRWSFTFQSYVQLTMLKIHELMPENGNVKVMERSLYSARYCFVENLMQKKLISPCEYHVLNQWFNNCLPAAQIDLIIYLRTDPDIVFERIKKRGRPEESKITLDYLRALHKLHEDWLVHKKFSLPAPVLTIDANTPLEDLMAIYEEQTGGILREHQILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I610</accession>
    <name>A0A922I610_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_006326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I610"/>
    <dbReference type="OrthoDB" id="10043580at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040219">
        <property type="entry name" value="KIAA1143-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31195:SF2">
        <property type="entry name" value="GEO02494P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9522766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="158" mass="18530" checksum="F74BB80403962046" modified="2023-02-22" version="1">MAQRKRNIEFSRPEEPSFLKKMKNQMGIQKDFVTIDTKKEKLNKQDLEYRDEEPVYVVDESSGISEKELEMFKAKTKQEKDYQKDNESFEQRIIFKKPDKSNTNDDDQSGSSSTTTFQTTKKTKNFSRSNLVDKDRIKKVKNSSLLSFDDDDDDDGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I668</accession>
    <name>A0A922I668_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_005819</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I668"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9522227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="288" mass="33986" checksum="A4F21E8C6F3C3FD5" modified="2023-02-22" version="1">MESPIPIITTTITNSSDTNEIFHSWTEMILTLFFDNHPIDVQKLDFVSTYCDNSYINDNRLVFWYTIFSVSKIFELFDTAFIVLRKQKLITLHWIHHILTLVYTFYIFGFTAATARWMVTMNLVVHSIMYGYYALRALKISIPRQIAMAITSAQIIQMIFGLIIHSHITWLKFSPINHQQCDCPRDGTIYGLLMYLLYFYFFVKFFIDSYGFMKTKSKNMTKTMKKSNEIHNNDKYDNLISNNIYNKNGYIGNFKPLMDDNNNDNNNNNNNNNNNNNDDDERKMKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6Q7</accession>
    <name>A0A922I6Q7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6Q7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8475" checksum="C83416A96A6FAF1A" modified="2023-02-22" version="1">MLSLAHSSWHLPELVISIQHQDIVAILPLEFQSLHYYHENLPNWLLATIHHRIATANMVAIDCIVHTMLVAMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6T6</accession>
    <name>A0A922I6T6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_005923</name>
        <name evidence="3" type="ORF">HUG17_3176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10250504at2759"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
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    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7639143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9522343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="183" mass="21410" checksum="485946D13F4FAF53" modified="2023-02-22" version="1">MTSEIIDGDSLTKIITKELDIGLYPQFMGREESCVNKLLKQRKFKYNPDLNGILIRFDDLEFLTDTGRIIDDSPLIFWKIRGKFHIFNVQPNQILKSFINRIGKEYIGCSFAGCIDVTIKFECQTFDHEQIDDICSSLNISDSITFKVKRFIPTQRYIEGIIDDEIFRIILNDNNDNKNRIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A922I6Y3_DERFA</name>
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        </submittedName>
        <submittedName>
            <fullName evidence="6">Cysteine and histidine-rich domain-containing protein rar1-like</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="7" type="ORF">DERF_005461</name>
        <name evidence="6" type="ORF">HUG17_3538</name>
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    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="CHRD1"/>
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        <property type="entry name" value="CS_dom"/>
    </dbReference>
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        <property type="entry name" value="HSP20-like_chaperone"/>
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        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
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            <end position="66"/>
        </location>
    </feature>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH7639505.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9521835.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAH9521204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF9">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="668"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9521204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="830" mass="93096" checksum="95936D3AD9AF2AA5" modified="2023-02-22" version="1">MSSSPTSGEDKIHLSTLNKQRSSMITMDSHIPSPSSMDSGFESTGSPINSMLQKTQSISVKEQSTLNSLKNIERSDELDVQTLATVIQENNKEYMENLNHIIETFNAKLGLTNTKSNELVDDRTTITDGSDDHEPIYRRSSLTNVMNQPLSSNIKSTTTDRSVNLDRGVSGRRNSTQWPIGTNRSSPFNIGSGHYQKQQLRHSRFSNVNLLSKSAPISDNYFFDEINRDNNGKCKSSFMNEWRLANNSGSFLNPNASHFSPTDNDYQQEIRSSSVHKNDSTGKKISGKVDKGALFVLDEEFFDRKERNSKNFLQMLAETGVDDDGPFGDFDSSYSQLPFMMIPSTAIESMHSPDSGQCLNSNSSFGNIVASSFINDMKQQRSSTTNISDDSSFSFDNVLGKGSISKTKGSKVANNDEQKHMEQQSQLDTNRSLFGNIHGLSSLINQPSVVASGHSSLMVPYSPLSTPSSSSESSSMLLVLQQQRTYNANAIACVNDELEVRARKHREEASRVDQCQSIFSINQFEFKSQRSVTYSVKVFLGGVLWDMTNEDMLEAFRQFGVVAVQRPGKEVRPSRSSRDLSKAGYLYLIFDDSTSVERLISVCKITFDNEGSKFLYPLQSKRSRKTKNVQVIPWDKNDSFHYRPGFPHHDTMATNNAGNMHSMIDESRMVFLGALHGMMNSKSIFEALQEIFGPVDYVILETDRFDYPMGFGRAQFATTSAYQRAINARFVKVLSLRFKKTIQVDPFLADQKCSQCQIENGPVYCFECRHYYCRNCWTMRHNDPGKEWHKILMKKVSTPINVPAAIAASPNSNTNTINTNNTGITSTKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I764</accession>
    <name>A0A922I764_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I764"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="7792" checksum="BF022519A04CCB8D" modified="2023-02-22" version="1">MPLNSSPSSEVEVASKETHSVVCSFDKAFFHCSSSAHVAAAFASNRWCKNGAFTIMQKATAVDDSMLSVFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I795</accession>
    <name>A0A922I795_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Endothelial differentiation- factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EDF1</name>
        <name evidence="5" type="ORF">DERF_006147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I795"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000015">
        <property type="entry name" value="Endothelial differentiation-related factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="4">
        <location>
            <begin position="79"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9522583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="145" mass="16026" checksum="D14F2244C446E159" modified="2023-02-22" version="1">MSDWDKVTVLNKRPARASDLRSKQAVNNAMKSGVPIETTKKFNAATNKHAGPSVNAVKLDQETEDFHHNHVSMDVSKLISVQRQKIGMTQKELATKICEKPQVVNEYEAGKAIPNQQILAKMERALGVKLRGKDKGQPLVPKSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8E6</accession>
    <name>A0A922I8E6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
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                <person name="Li M."/>
                <person name="Law P.T.W."/>
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                <person name="Cai Z.L."/>
                <person name="Qin H."/>
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                <person name="Zhong X.J."/>
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        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
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                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
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                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
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                <person name="Zhong N.S."/>
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                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
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                <person name="Zou J."/>
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                <person name="Tungtrongchitr A."/>
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</entry>
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                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
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                <person name="Cai Z.L."/>
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                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
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    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
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                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
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                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1633"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1657"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1678"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1731"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1762"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1984"/>
            <end position="1995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2077" mass="235538" checksum="B80EA244E5D22B19" modified="2023-02-22" version="1">MMAFQKSSSSSLKFLMILTIIIIIINFNDCELSTLVTKNVSLFNDDNLDVLYLSKDSSNRKLFHNNNNDSMIPTNLNENFQDFSITFEKNQLKKQRQQQPQQQQQQSQFLYDDNIKEESSVPYTAALAPKTNFLSKSNIIDKESKIVSLNNSRTYVPVSLTENGDEDDDGDDIVQPAPVFIPTSTTTTKLNDFKSTTSPSPSVSVAMKPRRKKKKKRQQKISNNNNGTLSSSSSKHKHGRRRTTKPPPPPPTTSVLQLSSTLSLDNFVGHQSFPSTLSDYKNQSIKNPIVENNYIPSMDTLPLSSAMISNHHHTNIRKAKNNQTITMMKPEDPESSIDIDYMDNTDVDDNLMMRNNHSNRNNNHYVSSLVDDNDYLMMLSAESQRIETVAKPERSKMISDATTSYSPQNIDIKSIFGNYKSPELTIDPFKLYEDASKADAKNNGAIDVTTTADERSKYSKIVNQIFDDKDGVDRVIVERRPVSSSLPSSSSSSVKDLDNFQVIYASGVNNNNKDKSGKNSPFTSSYDNHRTIIATTTTIIDPKNNPVVNTRRYKKKKLKNNNPLSFYYSTNDDDDDNSHNNFESIDHHDEALNPIYPLHNNPGNHHHHHRHHHHNHNHNDNGNGNNDGDLFRIKTNTNKNNNQNNMVQNFDPNNKIMAVIWDDDHHGGSSKFDHNHKQQQKPSNEFELKPDFFNFFDKENLNININNEPNNQRNNNDIGGGNNNQKKSSSSFRDGNLMVDNFFDFDLGGGGDRNQNHKKNTLDKHRNNNKSKNDDFHKTTFFDMKPPSSSSNHTNNLKLEHFLGKLDGGNNNNNNNKSISHQQTSSSSSSTSIGLKTVVKNNNSPSTTIHQHRLKSPVIKIATNDNEREIELKNLFDSNIHGNYYDRNKAYEYLFTMMNDADDDRQRRPPNQSSFKDILETSKSTTTKSPSSASISGHQRSRTRTSQQQTTTNHRKIDNDIYRIRKPSSSSSLNQQQLTNKFVAKNEPIFPFTTAIPIKTTATAVTSSTSTNIVDSSPSIDRTIDFKQNQNIKFNNNDDADDKQKQTSALLNGDEKFYYYSTPFTTTTTTTTISNNQQQQQPEITTEDYVLYPKGSLINQKNPEQQQQKSTLKSSYIANSGGGGGGSSNNQITEIDQNQLAQLLEYYRQNDLNQQQQPITSTDIQTTTTNKPIALSQPQSSIHQFVENVVIDNNNNRNKINNIIDSINWNDNNNGGVTKAKILRPYNNDDHYIQQQQNVQILPPTTTTTTTTDYNLPTSTPTQQNAQSILTMITPTRKDFNFNITPKTKLNYDDQVSIIQAPPTITSTSSSLQNIDEVTLGIRPISIISSSNIDDNQIKTTTKQISQPITFDAFHWSSAFSNNDNNNNGDDGKWTPRLRQNQSYVPNQQWNHRQSFGKQRQTPSRNFFNNNYRQQNITDSLINSYTPSPLNVVRILPKASVENIPLPPISEYDVPEIPKQNQDYIVKVEKISLTNLDDLRNNIAGTADVMVSNDNDNDDENVMKTPTSVTTTAKSTSQLRRPPPKNQKSKSPQKLQERIKNKNKNKNTNNKNNRNMKKTKKERSKSRRLQDVSTTSTTVSPDDVDEDSSSPIDESEENTNGDDEREEEEREMENTTEKENENEEATTSTTETPETESNEDDTPTSFEENDDDDIETESSSTTTTTTPSPSTTNKPTMMIPPYPPYPLPPMMPPFMFPPGMPYPPPPPLPQMPYGPFSMPMFLPPSSPYSSQMTYRQPTPNHYTAKQQAQPNVSQRPGPPYQTPSSPATPQSQQQQYQQPQMQYQHPPQTSYRPMQYTYPPPPTSPKQQPQRAYPSTSLPPMQYPPTQQPPIAYAQPKPVHSYPSPTPHMYHSAAAPMRNYPGSNHHHQQVPPMQNAKPIAHQYPTAAARQPYAPQPQMMNSYPKPNMPVEINKNIVINAPDHGSGYPPYYKRQDSSYTKKNHEFDNAPKFDISLDVVKPKYPSYPSYPKYPQPHPPVATHSAPSSPPPPPQPQQPMMPMYPQMYPPTNPDSKPKNIFMSFKDNLKRMLPKLRLHSGDPYPPELDIYYKQMNGTYNPMDPMENFWTNINRNDNNMNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAB4</accession>
    <name>A0A922IAB4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_001832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAB4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="60"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9527839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="146" mass="16970" checksum="DA838E6B270A6BA5" modified="2023-02-22" version="1">MNESVKKYPKLLLLTLNSFILCFFVFLVILYPVLQDEQQAAIDINGIRNSRGIWLMAAQINCYQCGQLIEPLELAFRIPYGHKQLIHYHVHCFTCSECSRQLHKGELYGLTTNTHTGLNIYCEQHYRQRQRQSSKCSNQGIMSDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC11</accession>
    <name>A0A922IC11_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HIST1H1B</name>
        <name evidence="16" type="ORF">DERF_003144</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC11"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0488">Methylation</keyword>
    <keyword evidence="13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="15">
        <location>
            <begin position="208"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="278"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9529252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="383" mass="42253" checksum="60B8EF05F8D0D6D0" modified="2023-02-22" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRILFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGEVEVAQTQATAGQSKKTKTSKPKVSKDKKPKAKPNHPPVSSMVKDAIKELKERNGSSLQAIKKYIQSHYTVDIEKITPFVRKYLKSGVTKGELIQAKGKGASGSFKLNKAAKSESGEKKPKKLAKPKSPKPKPSSSKPKTVKVVKSSKPSSEKKEKSTKKEKSATPKKAKLAVSKPKSAGKKAKKPTAKSSKSPKKVASKKPSTPKKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICA9</accession>
    <name>A0A922ICA9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICA9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037243068" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16551" checksum="500D0EA0B25D7C3F" modified="2023-02-22" version="1">MLALCTAVMTLRPFAIAYSNAYSATRRLAGSVISLILCTTPGNNHLFFVVTSCSIPLYSPSVFSRIVTISTLSYNFNDRCPLPIGVANGPLRPILLRCTDSIAFSGIEKRPSGPLTGVTSTRSHSIGTLAAAKIFSTDSDISGPIPSPGIIVTVCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICD8</accession>
    <name>A0A922ICD8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICD8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="658" mass="74416" checksum="E405A1980A8F5B46" modified="2023-02-22" version="1">MIDIHIFFVHISRLVSLEKHIIMKIRFVLLIVAFVLCTNLIHSTIAMPEQSTVATTTTATSNNVDENKSKLHRVRLISSLDDDNNDEKQKTWSSLFDESMVTSDENNNKQINATSCSEQCKDFFGTTNDDSEKFQSCINGCRYYTINLILTQKNISAGYTSSLSSVKSECFNSCVKVYPNDTKSISICNFGCRLADNAQSEKSKTRPIITISSVATHDESTDNNTVIDATESVKSASNDGKDEKKRTFSMFIPIRTITSANELDDNSQPESLDRVFAQNNMPSSLSQMMMSMVRSMAERARQMIDFARTQQQKMEDDRFSMDFDSSSNTGEAGGEAVSYERSMSVMMTKDKDGNNKLVVMREPPKITIHRAWNPLGLDFDRFKTEKATDLNQRLKQLEHEGEERLNGNKLRVLMPWKWSGGWDSNRVQQEQNADEDRLGNLIFHRINSFGLPQNQQNNDDVNHDADDDDVMVINTVDPNKSNSLPWSTCLISMMPLLYLLMVILLLYIIIWLFYSVPNYVICKNRRGRSHPSSSTNGRNSSETILPLSLDDDSYRERRRRLFQKLFHLSRAQRYCKLSAFTGFGEKTSPITPATKSPSSATGNDLSPTGSTLSFPPPYAEAAAFDKTFSVPETTLKVNELLTTLNSFPVIQKKNESNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE03</accession>
    <name>A0A922IE03_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE03"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="76" mass="9088" checksum="7D09D172F6E28EF7" modified="2023-02-22" version="1">MIVVVCRVDHHHRIHFVDDITIRVDRNLFVIFYFVIGHLIVVDVDHDDDDGCNYCIKHANFDIIHPLYLSIYHHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF01</accession>
    <name>A0A922IF01_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-glucuronosyltransferase 2A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">UGT2A1_1</name>
        <name evidence="4" type="ORF">DERF_004072</name>
        <name evidence="3" type="ORF">HUG17_9419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7638313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF01"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7638313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9530254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="252" mass="29150" checksum="DD741AAA7DC1ADBE" modified="2023-02-22" version="1">MKPIIERVNEYARKKDLLPFPNRLHPFSPYLNLYSWPRELRFKDMMNDDETIDGSIKLIGIDHMIRGTRLPFKQPEFILPDKLQKMSGKLIYFSLGTLGCVINGVMPRLIDILSRSKHRFIVSKGPIEIKLADNMYGEPFLPQLSILPLVDMVITHGGNNTVTESLYFGKKMLVLPCFGDQFDNAQRITELGLGCRADLHQSTADEILEKIEKILKDDKMSERVEKISKRLRQSNDRKRVVDYIEQMMVNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFG0</accession>
    <name>A0A922IFG0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Helix-loop-helix protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NHLH1</name>
        <name evidence="9" type="ORF">DERF_001724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFG0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19701">
        <property type="entry name" value="bHLH_TS_HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000027">
        <property type="entry name" value="Nescient helix-loop-helix 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040238">
        <property type="entry name" value="TAL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864:SF10">
        <property type="entry name" value="HELIX-LOOP-HELIX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="371"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9527718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="429" mass="49958" checksum="3F95EF4EE24C5C73" modified="2023-02-22" version="1">MDNNDDDEDRQRYRFITNSILQQQQQRRRREKILKFQPKNSLINLESMMDSSSSSSSLSSSSSSSSQNIIMGHHRLQSSYECFDNHHHRQQLERQNICAYHHNHHSTNNNNVVDSNYSITATTTATASIMLNNDNQIFYQQQQPQQQEYYDVSQNINRIDVDHNHQQQQQQQTLFNNNIDDKLNSSTLQILDNDACDDDDDNNNNNVNKKLLLVNHEPEFNYEFMANGKNSLQQHPHHTTSSSSVNNNHQHHTTSLDYCLINNSICSTCTSSSSGLLQQQQQQQQQQQQQQQETTTTMNNNEKSMMNRKRGRKQSVKINHNKINVNGGRNNGKTNVNGQPQQHRQKKSEMDPELAKLSREERRRRRRATAKYRLAHATRERIRVEAFNVAFAQLRHLLPTLPPDKKLSKIEILRLAICYIGYLNHVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFH0</accession>
    <name>A0A922IFH0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_003094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFH0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="3">
        <location>
            <begin position="95"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9529200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="303" mass="36184" checksum="E427BFFFCDA66748" modified="2023-02-22" version="1">MTAAMLNKLYQIDQMMNMLWLKIFIFIWLWIMTCYCKKTQVKIAHSSVNNFHGHLDFKHIDENLLNQRHRTDVNASIGLKPRNFIGPEILRELLDECCIYEDSKYYYRVCMFRNITQHEKSKYYYHSFHAILGIWKQWYVSSENFDFLHYINGDECMAGFQRQVVLKFECQLAGESKDLLWISNVTEIHQCIYLIKMKSQLFCGTVYSHLDPIGQIEWNLIDSLHSKNQLSKQEYTTYLQYILDDYGLKLLIDGQTFEDIVRVDKRESIEQNDQKKFLDEITSLKKKLDDCENSLLNKRSIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IH68</accession>
    <name>A0A922IH68_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein phosphatase 1D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PPM1D</name>
        <name evidence="8" type="ORF">DERF_004094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IH68"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="668"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="736"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9530279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="841" mass="96155" checksum="6F7A21605A126D39" modified="2023-02-22" version="1">MVCNIIMKLHDEESSHHYHQQQQFESSNNLRLRISVSSHQGSRKYMEDEFVIIHYEPPTLTTTIKNGNDHQESNVFHKSFAFLGIFDGHGGDQAARYSRQNLCHNIVRQRKFWSDDDDQVCLAIHKGFVRTQKEMMREVEKWPRTTSGLPSTSGTTASVLFIMNGKYYTGHVGDSRIVLGRKLKNSTRWQACPMTRDHKPESPRELKRIEAAGGQVMNKSGIGRVVWNRPRRIIRSDDSTIQIVYDLIPFLSVARSLGDLWSLNRRLNRFIVSPEPDVKCIPMDMMTDKCLILASDGLWNMINHKRAIKVVQDFEEINVTAFDRQETNVDGHDDDDYVHHLIDSIMDHHNKRIIHDPGRSHSLELFAACIDRWMTARTDNTTVLVVMFDNNNITNQQQQGNHHNKQIFDQYEFDLNSDDSFGSSSSSESTMTTTTISPLSPSSLQSSMIGDTIHSFDCFDSQQTDEKYLGIKPEDEEEIESIVDQLLNRLTMFNTTTNTNNDNLPSKNHHYSELIDLEQMSSIQVTTITSDTDNDDKNNPIVSLTMNPIINAQSKNHLQQLMNSPQRLATNVYFRINFNYSFQINDFHRHHSLNNKLIVQSQTTTANNEVMANNNISKHMISSPISSNIITSSSPASPLLNDMMVVSKINLINSIENLSTSINRNGQNSCSSNQFNDNNNVESKTTTANSFKRKTSSISSPSSDNMKNNLLFDSSINNDHNHCSDNLVSIDLSIEIDDVNEQEDKLTTKRRRVQNNISNLENIKLPSTNVVNENRIQGEEEEKKKFILLTSHCHQVNQIEEEEEGKYEDLFIDHHHHRTSSSGHLIHHLNHHQPLIASTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KSA3</accession>
    <name>A0A922KSA3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Serine/threonine-protein kinase plk4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PLK4_2</name>
        <name evidence="15" type="ORF">DERF_014087</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KSA3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033699">
        <property type="entry name" value="POLO_box_Plk4_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046437">
        <property type="entry name" value="Ser_Thr-PK_POLO_box_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18190">
        <property type="entry name" value="Plk4_PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51984">
        <property type="entry name" value="CPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="51"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic POLO box 1 (CPB1)" evidence="14">
        <location>
            <begin position="312"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9493333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="613" mass="70815" checksum="5068F57905E270D7" modified="2023-02-22" version="1">MDSKCFVENLRKNYKNQSETTTKIQCSTITGDDDDDDDRGKHRWASCIDDYNLLDLIGSGSFGRVFRSYCKSNGQECAIKCISKQNSRMNLDKILSEVYIHIRLCHPNILQLFTVLEDSKAVYLIMEICHGGSLSKLISERKHQNSIYPILPYELISSLLLQICDALDYLHRNSIVHRDINLNNILLTQPYHHHSEQSNLVHIKLADFGLAIDQKQMRHGHRSSTKDDDELFVSTICGTPGFISPEIWNQQKFISYKSDIFSLGSIIYACIAGHTPKGDIILDSFPPMAADLITRLLEHDPEKRLQIQQIKQHIFLAGRINTKRLHPIEKQTNTLQMSIDCDGNVMMHFRNDNLTINVCHNGLLVDISHHQSMDLKKHHHEYNFYELPEKYWKHFLYVTKFINLVRSKTRKIIINCGDWLNKTNNRFDNSDSKKFINKCILMNDGHFEVNVYDGILNENSTYQLDEISKSLDHDLKQNVNKLYELYSTTMKLEQTLEIQSKKLGIDLFPITIGIDSKLFETSSSRLSENNSFLTSKILRSIPVNGIGHAIQFTNGSIKVNFDDGSDLCMDRDNRIFYLHDGILDRYHKDDKLPDFIVDKLTQLPQVIERLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KXQ7</accession>
    <name>A0A922KXQ7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KXQ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039656">
        <property type="entry name" value="SYNRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059024">
        <property type="entry name" value="SYNRG_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15463">
        <property type="entry name" value="AP1 GAMMA SUBUNIT BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15463:SF2">
        <property type="entry name" value="SYNERGIN GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25999">
        <property type="entry name" value="SYNRG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="173"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="654" mass="75868" checksum="6ADAB25C03310F10" modified="2023-02-22" version="1">MEINGMEQQQPNNQQQNDSMKLKRDTLYKQQQQQRLQQNDITRNKDLSADQLIKNILEKVDTDAKITKFYNTHHYQQQQQQQQQQQLLNVNTQQFHQNQCNQCKPFKIINYSDFEFFFSFSAWTNNIHSKPIETSSATNSSTNFYSPLVIPQCFYLHSEIPEIYLKIWQSVQYNLVGNGESEFCDRDRLYQILITSNLSNDVLAKLWSFVNRTKPGELTRNELFVMLALISLVQQNVANPLQELYSIQTIPVPYFSGFSFAKSLFCQESTATTEPIKQIENLSESSFGENEFCEFKSASTNVDDNTPLADLFVTPQNSTLNPIDNIMTEDLFEVSTITSQLEQTQTKNNDNDNDGDDDDFEEVNHTNNDFGDQEDLFACTVVQSDTGEQEDKYSFFRKFQNEISVQEEFGDFHSQPIEQEFSTNHHQEYVHTQSMSSTAWFEHEKKNLMNKYQIRERILTAIKQVMHKTFNVLAVNHDETSVIEALTSNKGHTFVYKIAERIKFTVKHDDDDSDDKCRTLVDEIDRNWNSIHNLMKKASITLNDRISQKEFHYENGDDDKKCWICSTRVILGNNNNNNDDDDNKQVESITNDSLGMTIDANNGGNDIQYHLTCANFWLNFVDTTTLPHHGERGHDSIDDNDDHYGHFHSITTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY37</accession>
    <name>A0A922KY37_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY37"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9502054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="99" mass="10883" checksum="9DE282DB8205C07E" modified="2023-02-22" version="1">MLDNFSNTSSSLTTTATTTCESMANNNNNIRRSISKDSIDTDIIMIGNLNNNNHHQRHNSSSLYNATTNTLTSCGGGGDDMDLYLKNLNTTTIFFKNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYJ4</accession>
    <name>A0A922KYJ4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MAGUK p55 sub member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MPP6</name>
        <name evidence="9" type="ORF">DERF_012560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYJ4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10832">
        <property type="entry name" value="PDZ_MPP6-MPP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11862">
        <property type="entry name" value="SH3_MPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000069">
        <property type="entry name" value="MAGUK p55 subfamily member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037940879" evidence="4">
        <location>
            <begin position="18"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="8">
        <location>
            <begin position="84"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="182"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="266"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="6">
        <location>
            <begin position="392"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9501737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="620" mass="71618" checksum="5D91186C1AE5EB6C" modified="2023-02-22" version="1">MFLLIVVTITAYDTLRASFEVLNDQSDNPQIADDNKADCISTTDIDFLKGLIESPVVKNLLRVQERLEETAERIRQNQQQNDQWFNDARTIVEEVKSICRQPQMLRHNPKEAKELSRLLDDPHIDALIESHDRIAQKDYRETKLAAEEEYEMDIMNGNNCVDGDMAMIGSTHNDIATSAIRMVGIRKSKNEPLGMTVKVEDGLVVIARILAGGLIEKQGLLHVGDIILEVNGQEIDSPEQLQEELRKSDESVIFKISPSAKDPVPASACFMRALFSYDPNQDRLLPCKEVGILFKQGDILEVLNQEDPNWWQARRVDSPNSRAGLIPSQELEERRRAFVRPEFDYATKTSICGTKITKKKKKEMYHLQSNFEFDKAELCLYEEVCRTPPFERKTLILIGAQGVGRGQLKTRMVNYDGERFEIPLPHTSRPIRVGENDGRHYYFVSREQMEKEISEGKYLEYGEYQGHLYGTKLDTIRNVIRSGKMCVIDPNPQCLKLLKNAEFMPYVVFIAAPALDQLRYINEMNRSNTYGSRTYYTFDRAVGRSRRGRTMQSLAEFYEDEDLQVTIEESARIQRLYERYFDLTIINNNYDKTFELLREAVDSLSIEHQWVPINWIYNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZM8</accession>
    <name>A0A922KZM8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein Dok-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DOK7_2</name>
        <name evidence="3" type="ORF">DERF_012026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007528">
        <property type="term" value="P:neuromuscular junction development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037746">
        <property type="entry name" value="Dok-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21636">
        <property type="entry name" value="PROTEIN DOK-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21636:SF2">
        <property type="entry name" value="PROTEIN DOK-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01244">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51064">
        <property type="entry name" value="IRS_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRS-type PTB" evidence="2">
        <location>
            <begin position="78"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1336" mass="150374" checksum="AC7B922F5EADD098" modified="2023-02-22" version="1">MKYFQSSSSSSSAMKLKPIFELEHYLGIESGFVHDRESNTMAIICIEQTILLAFETREILLQWQTKLQEHFCKVVNVPNNGHNTITSNHHHHQNKIKCGSARLLLQDSIFCLVTGIPPSLMCYWSIKQLRRFGLIDGKFCFEGGSQCGKGIGLHILYTSEPEELIRCFDLASNDQLNSFESSMSKSDSISHYSGGSGGGGGNNNGFIHKQRSVPSSDSSTGDSSSQLLSSCFGDVDTLSANYYCGGVGADGSMITVKNPEFYHSTMNLTTINNKQYTLSPSSSLNNNNNILTTKCSSSFSSNTIGRFSNLTSSSKLTGSNNVQNNLIECCHHHHHNHHHAHNSFVCCHQHPQQQQRNNRNNENSNLCMISTASTMTLKHSNFNSLNPMNASNIVEDGNSRTIINCDHESSTSYSSIHDVHSLCNNNLQNHRYSTSSSPPITKNNKTTMKIICNSNESNSSLFNSSQMNGTTNAESFNTTTTTTTTLTNGNYTNRLTANSHFHDVGNNDNNNDDSSRMNNIHLNFTTCTNRTTTNDDHNENIHEPIQTTTMSKITNKEIDSHTLLRSHNHHHDSMKDKESIIDHPYHRINFPGIITTNRKTSQTTTTTTNSNAMDNYDIPKNLCMMIMMKNDDDGEKQQNNVCVCNNNNNNNINGHDVDDKQPSLHNHHDVDDGTNMTKKKICSSSLNGCCRFCYYYSCCCCCCCRGSKCSTAAATTSTTKAENSGCFCNNNNNNSSSSLHCDGFYGQKSVYDRFLKNDQPTTMQSPVNCFHNGITYETTATAAVSTNSSSIHNDGGGGSSSGYATIVKSSCNQSNHHHHQQQQQQHRIYNETVNSSSSYFRLKKPQEINYENINFINSMQYYENMCFDNNDGKMITIATHHTSLNQTSDNNDDDDDHHHHSSVHDNIHEQKSKEYSKEKDMNDLDENHDDNVSIEEKNLKENGLLLSKIINDNNSVANKTITEIVDDRMEQPTNLMVPINIIENQERKQQEKIAAVKNDSSICSMMMVDNNNNNNGQHTINVGNEIDSKTNSNRRFNNNQDESKKHSMNEKEEAEKEVKIEKNEKEDNNQNSLNDASDDDVGENVVQCSKKDEPNNNPSVSLNMDKNKCNEDDNHFDQNDDDHHNISNHDHKVHCSKNKKDDIYSTMIHCSKWNNESNVDDIERKTFNHDLDSILNERTKKTTILLDTMMADSIIQEFKSPNRNNDELLNGIKAKVQNTTTNDSHINITNLIYSTIPDDDDDNDNLEKHLTFSDSNILNIYERKRSQSINDIVNLMMMTSTTATTVAAASAAAKLNKQTMKRKGNSFECLGQQMELWNLQHQQQQRHAFIVPLDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZR9</accession>
    <name>A0A922KZR9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_011628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZR9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="381" mass="43437" checksum="51D6F3A5BBBD1218" modified="2023-02-22" version="1">MFARKSKNLHHYRRHNYLRRTKSESELMYRKQEKKLKHLHHRNQNRRRRFIDYYDRLSPPPSLSSSSSSSSSLSSTKCDHQNNSNGCDLLVNSYKHNHRHRKHQFYGRRSNSIQVLYNLTKPNKIQTTKCSNGQQQQRRRPPISSPNRLQMTKANLRSCICCPQCSVDQQKQQTITTTGGGGGGHMNSSINKKRSKFNRANQSQNSSSDYDDYEKHQRPKQQQQPQITKSDPNVLKSSSSSSLFLLKFKSGTTTTTTTTKTLPPPPLLPKQQPSSTTSVSVDSSSNNNNNVVNVFVPRNYHINTTATTTTSIGGGRQLNNNKRMSNPRIHSMHGLTRAKIKTVKITLVVITCYVLCSLPFICVQLWAEFWPNAQKSPIYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1B5</accession>
    <name>A0A922L1B5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Caspase-1-like</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Caspase-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CASP7_2</name>
        <name evidence="13" type="ORF">DERF_012021</name>
        <name evidence="12" type="ORF">HUG17_9209</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase C14A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7638104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1B5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990525">
        <property type="term" value="F:BIR domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045751">
        <property type="term" value="P:negative regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045476">
        <property type="term" value="P:nurse cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043525">
        <property type="term" value="P:positive regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000001">
        <property type="entry name" value="Caspase-3 preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454:SF232">
        <property type="entry name" value="AT03047P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10454">
        <property type="entry name" value="CASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038001">
        <property type="entry name" value="Caspase_ICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Caspase family p20" evidence="11">
        <location>
            <begin position="71"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="10">
        <location>
            <begin position="210"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038001-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7638104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9501155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="303" mass="35351" checksum="3B6A4235E7E1DA47" modified="2023-02-22" version="1">MEPDNQKTDDTSNNNNNNNNNGSKSNTEFDSGFLFNLCSIKTESKSTMQQQQSIQISSKRDDLYYNMGHEYQGRCIILNYESFDSEELSRRRGTESDVRKLLQTFKQLNFVVQMYNDLTQQKTFDIFRQESMFDHTNYNCFVVCVLTHGSNGILHTKDKKFDTNKMFEFFTGSRCPTLVGKPKLFFIQACQGEKFDSGVLAHDSPLSTPNYFMVPNYADFLIFYSTFPGYYSWRNVEHGSWFIQTLCEVFDEYGRKYDVMTLLTIVCQKVAINYESKVPNNFSMHRKKQIPCIMSTLTRLIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3J0</accession>
    <name>A0A922L3J0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3J0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9512016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="266" mass="29510" checksum="D5920B8241492B5E" modified="2023-02-22" version="1">MENNPSDNEKLIDVSTFIGSNDSAVDQFELNCNFSIVKIADDEMKKNSQTNDGSNSDSVNIFQASSSSSTVSTMENSPSDNEKLIDVSTFIGSNDSAVDQFELNCNFSIVNVDNNKGEKKIDEVKESYKFSKLDNPIDLDDYIIEPDNRIDHFVDLDYKADLFLDELVNNKSFIDGKIADDEMKKNSQTNDGSNSDSVNIFQASSSSSTVSTMEHSPSDNEKLIDVPTFIGSNDSDVDQFELNCNFSIINVDSNKGEMIPEKKIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3J5</accession>
    <name>A0A922L3J5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3J5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9512031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="106" mass="11659" checksum="5E469C4CA8367D6A" modified="2023-02-22" version="1">MVAEPPENPERQIDGADTQSFILTRSLRINVNANELEDDKETIGDGDDEIENEDDEGIMDRSEEFERTEIAATPDVEDEVDGTEAEVDAEVDVAATEGDDETEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L438</accession>
    <name>A0A922L438_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_010736</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L438"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052660">
        <property type="entry name" value="Erythrocyte_Invasion_ImmMod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16021:SF13">
        <property type="entry name" value="ETS DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16021">
        <property type="entry name" value="MANSC DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="624"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="3">
        <location>
            <begin position="192"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9505974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="642" mass="72743" checksum="2BDA54716D28BE34" modified="2023-02-22" version="1">MERNLLIFIISIFVVIIIINIDSIDSNSNIKNGHHQQNNITTIENKSIQSIPSSSSSSLPITVNQVSIQSDNNTTTISTPIISTTSIENNIQPTATIITTTTLLTHHYNDDDGDGDKNDHNGTTMMMMMKNIKTSTSTTSTTTVPTTTTTTTSTTTTATMMMMNEKLTKKSHKNKWSVNSEGNHNQLPYRLNCSMDKMTIQVNLSSLYGPTLSNSSRNQMANDEPYVYLEKLRSFSSKFFFVDQKWKNMWPHFSYHYRMIFIVVVQQKFMIKLPVHVSFIIELLLNPNMMETGIGQRSIYFKCSQPNLDQLLGFKVETSPLDDDDDQVGNSSTQASRIKRESSSSSAWIQDSNGRLVNFTEIDLPENFMEAEVLDFTDNITARAPYPHLNLKVKRNGRFVNQSLNVAPGTPLEMIIYLDDESKHVYGLLASFMKVTDNSNRQQEVIVLNGCSIDPYIFGNFISNDGGDSISARFRAFKFPESNYVMFIGTVNVCLDKCQEVPCGNGIYALGRRRRRRSLPMEMPKDPNKVFEIEMMAYLRIGYSDEELAAKHIHRQSIIQATVTNATEMINTESIKNSPIVAHLIDDHRTSSMNIVSDAQFESLTSSSSSSLMIESSIFNNAKHYHHFIIVFMIIFRIIFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4C7</accession>
    <name>A0A922L4C7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4C7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="107" mass="12009" checksum="F83EF856E7A3509E" modified="2023-02-22" version="1">MARFINHNQLLLLEHLIFRFKVSTNMSQIKPILLIRSLIILVKVRKPPSGNPTTQSALIIIKSSTPPQPAQHQQRSGIKSPILVSMTTPYRILMPAAYNNSNDPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4D7</accession>
    <name>A0A922L4D7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4D7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="863" mass="100300" checksum="116406C2C81A6940" modified="2023-02-22" version="1">MWGIAEKNETICFELDIDSWERINNHMISISNTEMPEFHLMKLKLDLERSNRLNVISKSTAKKRKFDPTNELVISHKKLRNGTITEVNCSLHGTVHTNYKDLYYHLCEDHPESFIGPSNENHDVLDVDQLPTNDDDNINVDQLPTNDDNINVDQLPTNDDDNVNDENDDDNVNDKNDDDIINVDQVPTNDDNVNDDNDDGDNDDDDGDNDDDDDDNDDDYDDDNEETESCSEAEWNSTGYEPAVNHEDRNSFFDIVKDELSLELYSKFIEFCKSINKCRLKFHMTQNAISSVHEAHKNMFELDSKNQKLQNFMTKFVNSIYLQKKFSENLPTYVKSEELKLTNGKKYHYIGIEKILKTHIIDDNLIRNIFDENQENLSEYVRKNGYQNKLRIVLSGDDFGVSNPIGGAERKLFALYMDTDNAKIYNTKANQLPLVLLCERSHITDLNELFSPVKRDLKRLMDNGITVQYNGIERKLEVCLAYVLGDNLGVCEMLGMKRNFSKGFICRYCGLTYNEMQTGIYETRSLNLHKSISLYKEELSKLSNKKYKSPYGIKRKSCFDGLGVNIFQISPPDLFHDIVEGFGPRISQILLKSSSVSRTQIKNKIKQINWINGPVKVKEDFSLKGKGTQKFEFIVRMVEIFPEWIEFPPEIYLSLRKVIYKIFSPSSFEMNELKNDIQNLVRLCRPHFQVAKLHFAEHYPEMVSFYGSLLPYLALRFERKHWQLKCMIRMSNNYMNIAYSIANSHQEVQALDFKTPGMLNEMCNEGLMPVADHPFSTHKKIVREILNEVGTFLEVKNFETNDGLIIATGDTWKIVRKVDQHNLWQYAELTNQNIKKELKELSHNNSFIFQFKNNWMINSPIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4Z0</accession>
    <name>A0A922L4Z0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_011627</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4Z0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005000">
        <property type="term" value="F:vasopressin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001817">
        <property type="entry name" value="Vasoprsn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF161">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00896">
        <property type="entry name" value="VASOPRESSINR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU046427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9506919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="147" mass="17307" checksum="6D79B2843C4849FE" modified="2023-02-22" version="1">MQIMYNKNRKLRKNRMYFFLAHLSIADLVTGFFNVLPQLGWEIASRFYGGNVLCKMIKFLQILGPYLSSYVLVMTSIDRYQAICHPLSNSLAHTRRSRWMVAVAWIMSLLFCTPQTFIFSYQKISPTSDDYECWATFPEPYMTKMIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4Z5</accession>
    <name>A0A922L4Z5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4Z5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="7044" checksum="654A1B94C60E95BB" modified="2023-02-22" version="1">MANGQQPIIIHHHQQQQQQQQQQRQQNMDTKYQFRYELVINSILSSMMAVDGNCFCYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6C2</accession>
    <name>A0A922L6C2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6C2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037380081" evidence="1">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="107" mass="10934" checksum="355EA75D67E0D127" modified="2023-02-22" version="1">MKFLIAFAALIAVAAAIPYAPVVSYSAPIITKSYAVAPTYAAPVVAAPIYKSYAAPIIAAPIVKSYAAAPILTKAYAPAYGYGGYGGYGYGLGGGYYGGYGYGYGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6L3</accession>
    <name>A0A922L6L3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_008057</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the paired homeobox family. Unc-4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6L3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="526"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="528"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="279"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="443"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="307"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9517379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="587" mass="62323" checksum="7922DDF9532DFFFC" modified="2023-02-22" version="1">MEGSNPLLPLQSPSTTTSAFGGGGAGSSATSNAAGTLARLGGRPIPGSFAHFASPIAPYTMPSFMATGLGAQQQQPTATAVAAAAAAMAANHPAHQAMFPNDHSSFQSTLASMAAYSFDSLLNANFNQFANLLMMNPAMAQHHHQNAAAAAAAAAALGLQPPSALLGAAFAAAASKSSPSSSPASVSATTALTTSPISTTINHHSPPPVLTNNSNHLNSNHHHHHNHQNHNSSSPNSISSSSSPTPLSPGSYHVRHHRHDLLIGNNNLKENLNMMSTVMNNNTNSTAANTLTTPTTTTLSIQTNNNKINTATPNKGTNRKGSSNINNKENTTKNGRNSGQNNHHDTLIMNNGRRNSQQQKQQKQQPSSISLSEMSIRTTKTTSSTNASPTSLSETSSIDHTSSICINNRHNNNNLMADKYHQNHNNDSTSSIANNGDLDICMSSPDILSSDDHDMNNMSSNNDNDNLIGNSNHNNYSINNNHNHRNGNGGGGGTSSSLSRRSCSSPSLASEDCGSDDENDDDPHDSKRRRTRTNFNGWQLEELEKAFEASHYPDVFMREALAMRLDLVESRVQVGAIYSFFSLLSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6M0</accession>
    <name>A0A922L6M0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_010211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6M0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9511778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="110" mass="12479" checksum="0EB8B80A37A48C3D" modified="2023-02-22" version="1">MSMSSSSSDLFDHYQRKYHALKIPPCDPGYFECDSGDYCVKQQFNCDDNEDCPDGSDESNCTDKYDSSYYNKLFSKRPDEDREKLTINCSLTIIPAICTCSGMGIFLCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6R1</accession>
    <name>A0A922L6R1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6R1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="136" mass="16020" checksum="24C6A2C14141B936" modified="2023-02-22" version="1">MTNIQPNTISSEFKIQNRENIKSNLTQPVQNRENGKSKLTPVQIKIQNRENNKSKLTRPVQNRENNKSNLTRPVQNRENNKSNLTRSVQNSHIETNNQIRFKIEKYNLTRDAVQNRENNKSNLTQSIQNSNRENFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6V8</accession>
    <name>A0A922L6V8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_005151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="895"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9521498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1446" mass="166519" checksum="26B8B78E6F9EEBE3" modified="2023-02-22" version="1">MLTIPDDVKQRLASARSNVSLLHVRRWDMARTELLRSELDELNQKLIELVGEEEIPEEELKKMGDYNKKLDLYMEHLKKMRIVVVRNQSNVQDDSGDHLRTSTPFNSIVNNFADTSSLNRCRPVKMDQLPTFDGKFAFWNAYKIMIEKLLINNTSLSEDLKKSMLLKTMKKDPEKFVTNLIGQRLSLAEIWSRVCVKFDDPQRAILEIKKDLESIPRIESENDVHDLKKTKDIVENANLAIKNLVSDVMFYTINLIQAVATRFYYKAQRHMLAKIKDFDQLVNYIDKLYDEALCYDYNKIRKDSPLKKQEPPMISNSTAAITTNCYICEKFHQNNFECLKNYDVKTVANLIKSKGLCFRCLKRGHLSKNCQMSSKLKCDKCPRLHATEMHEVIIELFQTKPKVIDESSPATEESMIGNAAAISVVDQSKNGFEIKKNSKSESRPLLYGSCNGIQSRMLFDYGSDVSLIDKELVKDKSNDSDKNCTVYSSSPLVGKEASRRKVSLERHKANLCNVNICTRPIIDLSENESDIYEPIIDLLNRQDNGDIDEPIIDLLNRQDNGDIDELIIEDDKIIDHSRNELFLKSDHELLNFEIENDLNVNDEDVDDDLKIVRKENGRYEARLPFLSDIRPANDFDKALIVWNKSFKQSENKSMKNEYEKQLLAYVDSDQTMVMDDPNGYLLPYHPIYRESASAPLCIVFNGSFGFDVSNQLLWKGHAHGLNIFDHLMKFRKGKFAVSADLSKAFLQMKVSTFGLVSSPVILTSVTKKLLCEQNFGTIAKSQIKQHHEMLLHDGIETTVPNLYHIEKKSVYYCKFCQIEKRKPVDQPFTQLPSTRTSFVALFEAVCIVLFDLLRYRNRKKFFGLLATGFVSRNHDLLMKIEKLWKQKYFDSLIQPENEEDNDHEPEATTSTNRGRPIGSTNRKYTVCEERLKTLRSFCLLAGAEPSTFEEAEKSEEKDKWKKAMNEEYDALIKHKTWKLVPRPIDKNIVSVKWIFRIKNDGRYKARLVARGFSQRKNEDYFETYSPVVSIETIRLALSIAATLNYNVCQFDVCTAFLNGTIDDEIYIEQPPGYVQNENLVCRLYKGLYGLKQAPRAWNKLFDQVIKSIGFVTSPFDPCLYVMFDDNNLPIMVTLYVDDGLICAPNIENIDFIIYHLKENFELKILKPGNYLGLEFRQDKSKREIYVCQKSYILLKLKQFNLDNSKTMNTPISSTNDWYLESTVNETFPYKEAIGSLLYLSTRTRMDISYAVSCLARFASSSNNNHVVAVKRVFRYLKGTIDYELCLGSKNGFKLTGYADADLAGDQQTRETTIGTLVSLNGPIIWSSKRAKCIIDSTCEAEYIATSKCSKDIQWLLILMDYLRLNIPKPIIFNDNQAAIRQIHGEVVSQKLRHIDVKFHRIRSLLGKVDVEYIQSSQQLADILTKALSTQLHQNLIDKLFKVLVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L761</accession>
    <name>A0A922L761_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_006636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L761"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="59"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="217"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9515862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="363" mass="40885" checksum="9E2B2FA8A574229A" modified="2023-02-22" version="1">MSDDSLTKKHVTDITTIATIQNHHLNNHNHHHNVHSITVEDDKKLVSKFKKPPIFGSAFGITCAMVSVLCFSFCSVIAKLLNSSYQIPGIQVLVLRSFIQIALCSIILFYQRSLPGYTDMRTNLYIFGCSIIGTIAVCCLFTAFNKIPIGDATTIYLTSPVFVAIFSFIFLHEPFRWLQSITIFITIIGVGFIAKPVFIFGTQQQQQTDQHYAQEILGQILSFISAISSSLALIFLRKLKSTSPIIILLWFAIAITIIGSIILVHLRLYRSLDWHDSWCIVLLVLIGLLSMVEQYFITLSLQYEDASTISVTRSFNIVLAFLWEVIIFQETITWTSIVGAILVSCCIIAIALNKRSYQQQTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L841</accession>
    <name>A0A922L841_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_004828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L841"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF144">
        <property type="entry name" value="ARRESTIN C-TERMINAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="168"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9521157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="451" mass="51925" checksum="F627595A43C17DAB" modified="2023-02-22" version="1">MDYIRQFDIRLEKEMYYPGECLAGHVILNTMENFKLKAIRVILRGKAQAEWKVIVSGDRRTVKDDQIFIDDRCSIWGKDGETGILTRGQHSFPFKFQLPESCLPCSFESKPCQIRYYIKVTIDIPYASPPQGMKYFTIIGPHIDCMDEQYLKPLVGRDRRSICCLCCRHGIVSLKAYLERSGYCCGESIRLKAEIDNQSEEIVRLRLKLVQHVNFSIERGVLGLSKELTHTVLEYLGEDVQPSQKFRFDSTDSLVVPVMPPTLLNICKLLQIYYILTVWIEMEKSNDDLHLNFPLTIATCPFRIPNSNKQPIIDYDVCCDHVEGGQYIGPEFQLGQVYDGSLGMEEGETIVLYRPVYVCVRKSTSHQSQSTQPQQQQQPPTISKGTKSETPSSHIHHHHHHHQQQQQQHYAHQHHHQRNQSESSTLTKQRQQSINNELTKNCGDPGPSRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L880</accession>
    <name>A0A922L880_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BOS complex subunit TMEM147</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Transmembrane protein 147</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_004961</name>
        <name evidence="12" type="ORF">HUG17_7862</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM147 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L880"/>
    <dbReference type="OrthoDB" id="9993532at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019164">
        <property type="entry name" value="TMEM147"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869:SF0">
        <property type="entry name" value="BOS COMPLEX SUBUNIT TMEM147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12869">
        <property type="entry name" value="SMALL SEVEN TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09767">
        <property type="entry name" value="DUF2053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7640395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9521292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="195" mass="22349" checksum="2C31A438CC7B0820" modified="2023-02-22" version="1">MTFYHFVNCLLLTFGPPVILYRFSVISEYGTLMRVLTGALSYILTQMSKMLIIAGLVNLTEFWEHLIDCIGLYYSMVHYQKASVASVKILSTALGWTVTESIFTRLVNFYINARSLQFDWHHLIDACGANIDLVQNICLCSLLWYWNRKSNKLYLAMIIGYILAISFTEFNIIHRTGMVMAFSIASMAILNVNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8K8</accession>
    <name>A0A922L8K8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plasma membrane proteolipid 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_000685</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8K8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9526614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23157" checksum="5484AA2DA115DAB9" modified="2023-02-22" version="1">MCWETERKEEMWCCAASVAFFCPPLSVLLLYGCGKEFLLNCILTFLCYIPGFLHALCIVFCPDRINPKKKFLMTEQACRAREKAEYLARARAREEAAARQAMCFKVIRRDELWCFASMVALFCPPLAVMMMTGCGIDFVLNCALTFLLWIPGFIHAYCIIYCPDHIDPNAKLQMTEAAIRWRARKEAERQAAAEQAQGIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8L5</accession>
    <name>A0A922L8L5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Beta-galactosidase-1-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GLB1L2</name>
        <name evidence="10" type="ORF">DERF_007910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8L5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037197286" evidence="6">
        <location>
            <begin position="21"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="7">
        <location>
            <begin position="51"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="8">
        <location>
            <begin position="423"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="9">
        <location>
            <begin position="570"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9517227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="653" mass="75863" checksum="D121E5A5A85AE042" modified="2023-02-22" version="1">MKITFFANFFFIFIIQNTVCLTASSLPTLYDYYTNNGQKITAGLDANGPEFTLNHKPFVIYSGSFHYFRVVPEYWRQTLQKFKAAGLNTVQIYLAWNRHEPQPGHFDFDSYGLNLTEFLHEIRNADMFAIVRPGPYICAEWDLGGFPAWLLKDPHMSLRTTYEGYLEPVRRYYRKVFDIINEFQFTKNGGPIIALQVENELFGDPENIIHKNRSLEYLDKLHQMIVDENHFKELLFTSDPVSVARSVPVRSLKYLLETANLNQNALDSLTQLKNNQKNRPIYVSEFWPGWFDQWGEHSHHRYAPLLFEQQITEILFQVNGSVNFYMFIGGTNFAYYNGARVTTSYDYDAPLSESGNYTEKYYKTRQLYDKLVASGRQPAIAIPTNPPPVVRAKAYGHLAMKEYLDFGQIIDQLKPVIMKQPLFMEFIDNSSGFGFILYRLKTKPIHTFNITGPIKDRAIIMIDGKILTKIEDGAKNLNIHLNQTEWFVNPNGEYTVDILVENLGRANWGTSLMDTERKGINSTILFDGNVCNEIHTYTFDLNENFMNHTAQLKWNQFLHDNDDKQKRHGPRLYRTRLSISNTTDTFVELPGWTYGNVFVNNFNIGRFDHRGPQKTLYIPGPLLRTGDNVFHVFELDPRHDSTQIELIDYPKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9U3</accession>
    <name>A0A922L9U3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_000057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9U3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000096">
        <property type="entry name" value="Carboxypeptidase vitellogenic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF472">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CPVL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9525927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="460" mass="52563" checksum="4A65F51203A35C39" modified="2023-02-22" version="1">MIKIKINSIIFIITLIIGLSNGFFLKNLYPPTETANRLIGTIDSKPLFLTPYIESGQLDKGRRLSEVVGLSGLDLKSYSGFLTVNKTYDSNMFFWFFPALTEKTDVPVLLWLQGGPGGSSLFGLFVENGPIKVSANGTPYMRDSTWNREFAVLYIDNPVGTDVAENLYEALRQFFTLYYEYKGNPFFLTGESYAGKYVPAIGYKIHCMGKEAEKSGINLQGLAIGDGFSDPKHMVDYGDYLYQVGLIDEIQRAHFKEEQRLAIKYIDDGQMMKAAQIFDRLLDGDFDKKSYFYNATGLNFYYNILYDRQPDDFGYYSKFLASAKTRESIHVGNLHFGDDSIRVEEHLLNDMMASVSPWIEKLLDGNYRLMFYSGQLDIIVAAPLTENFLRHLKWKRSNEYRMAKRLIYRVSPNDPSVAGYVRQAGNLYQVIIRNAGHILPYDQPKVALDMITRFVKNESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA23</accession>
    <name>A0A922LA23_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carboxypeptidase B1 (Tissue)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CPB1</name>
        <name evidence="11" type="ORF">DERF_004427</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA23"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000001">
        <property type="entry name" value="Carboxypeptidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF153">
        <property type="entry name" value="ZINC CARBOXYPEPTIDASE A 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="10">
        <location>
            <begin position="11"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9520735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="309" mass="35645" checksum="73EEB20625068BC1" modified="2023-02-22" version="1">MLLILIYIYNIYNSCPSIHPFINQSMKQKIVPENAEKISIGYSYEQRNIMGIKIVNNKQNNSSQIIFVECGIHAREWISPAYCIWLAGQLLTNKRLSSLNERYQFIIIPSLNVDGYVFTHTHQRLWRKTRSRQYGTNCIGADPNRNWAISWCQKGSSLDPCQDTYCGRGPFSEIEVRQMANFVHRYEGKIFAYFAIHSYSQLWMFPYGYTARRVDNYNQLRIASLAAVQSIRSLFGTQFKFGSIAEIIYSASGSSIDYVYDSLNVKNTFALELRDKGRYGFQLPNWQIIPTCVETLAGMRTAIDVLDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA39</accession>
    <name>A0A922LA39_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_002955</name>
        <name evidence="3" type="ORF">HUG17_4999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA39"/>
    <dbReference type="OrthoDB" id="10533156at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7641954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9529046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="492" mass="55316" checksum="9BA9E21EC7E5EB91" modified="2023-02-22" version="1">MATSANTKRLTNQVEDATRTLWDEPLVPIPDKITRVDFGDLTNATDEEIDDVVELDDHKNNIIKNDANFNNNNNTDNGQHESDDNDNIDIQHHDRLHDSRKNAAEQILCINSGPMSEGLLKVATPSSLNDTAKTICYFMSCLFIIGFLFIIAGILLYMDSQSEYILTAIVSFIFGIISLGSSIVYFVAYFFNKCSKRINQMEQKRYKTNQLQSSSSTTTVNLNISTTETDIASTAVIPGSSYSKEQNQSFQTNNRTIKSNLNQPSSSSTTVLSTAVDKFSFLNVDDLEQHVTPTATMKYSNDKNKSNLVTEDRFQTPNQTKNQFDANWRRSNSSASNSYGNRSRSRNILDTFAFRSPNQLTPFSNGLHSSSINRRHYKNHKSDSKSELLSNEHENMLFDVDHIDPVNNHNLNHNSHHHHHNLNRSSSLDMKFDESFSSTAVDDPDESKIIVINPGVKNSIKNGISKNGNSETFEKPFVIVQFNKNSSAKLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAV3</accession>
    <name>A0A922LAV3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dna repair protein rhp42-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001126</name>
        <name evidence="2" type="ORF">HUG17_4360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAV3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027877">
        <property type="entry name" value="Smim15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15086">
        <property type="entry name" value="UPF0542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8420" checksum="8780D6F82B2EB0C4" modified="2023-02-22" version="1">MFKMLEEFLAFISRYAIEHTSNFVILILLITTPLFALSAYLSLKLARSIEQQQKKIKSIEKIKMKSKAKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBJ3</accession>
    <name>A0A922LBJ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBJ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8480" checksum="B48CDDFD1FE3CBDC" modified="2023-02-22" version="1">MKITIFTVDDTDRIELINSNLILQSTKEQEKKEVKKKRMEIYHEGTPIVSLLLISKTIFIDLWLNYRSLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBT9</accession>
    <name>A0A922LBT9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">E3 ubiquitin-protein ligase herc4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HERC4</name>
        <name evidence="9" type="ORF">DERF_006014</name>
        <name evidence="8" type="ORF">HUG17_3124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051709">
        <property type="entry name" value="Ub-ligase/GTPase-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622:SF76">
        <property type="entry name" value="HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN LIGASE 4, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45622">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="64"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="168"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="221"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="273"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="5">
        <location>
            <begin position="325"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="968"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="4">
        <location>
            <position position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7639091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9522445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1304" mass="150407" checksum="115AC59434701D48" modified="2023-02-22" version="1">MIKVYCFGNTENGELGLGAIEDEHILTPRKQRLPYDRRKYTLVQLSSGRNHTLLLLKNIQLDQNVVFSCGSNDRLQLGRNGSWKKLEQLDGLIHHNIVKISCGSNHCLVLSEAGQLFSWGCNLFGQLGLGNREEYEIAKPSLIKKLATKQIIQISCGGNHCLALTKNGEVYSWGSNAFGQLGLGNSGYCLSMPMMLTSLQWTPVRQITAGGSHSAILSCTGAIYVWGKNEFGQLGLSDVENRSLPTLQKSLRNQKIAYINLGDEHSAALTFEGGLFTWGAGMYGQLGHGRNTNEVLPRKIFELMGVRIVQVSCGRCHTLVVSKQGRIYSFGLNGSGQLGIGNTCSKYLPVSIRGPWSELNTKDVIVRDNQRSLLLFDESVDEQEFRKTYTSSANDQTMDGSSSSSASHQSSDLMMEINEMETIVSEDEEKDIRDNQNNNDNFIIEEPEEDRYNNCQQQHQPCSQAKFICANDTVFDESNLSLQIDEYESDPDSDEEEGPNRLQYICKEIVAGKGDHSFVLTQSYMEQIMPKDSRRLSVNDEILKMKNQIFEQFPSISKESSIPLDIVDNIETIFSSFPSMNASFLCSPSNDDNDGNNANDNRNNHNDDERKKLQKFKQQENIHFEESINFCDGWINWQQAFHCFNMIEDAQNERIDELIYQLLCKIMPNMPDLTSLHKRRLELDDEKYKNEFPDILDEEVMRVYQILPLFHMFRMPTYCERSQKLITAYATSLNTLSERGIGCMKIRWYYMNRRFFKNLIEIFKNSVKLNLYEQYKESERNLNNGDPNIQLEYNSGHDIFHQASNFFNNLTVRSPDSPSSSSTKHFFIPRKIHFNLAVCLFALKRLYSVNKFSGKISHKEFYIHGISDWFDLRYDYYLWKNNRIKEPNVFYLCNYPFIFDPPAKTIILIADSAIQQESAANLSIRKQILMSIPIDGTIQVNPFIDISVRRDNIVEDTIHQLCLFSRYGEADLKKPLRVLFSGEEAIDAGRGMKKEFFLLVMKEMLDQKYGMFVEYKETNTIWFNHVMTDEDDVMYRLVGILCGLAIYNQVIIDLPFPLTLYKKILNENLGLDDLADLDPILAKNLKEILISTYKPDEFNAIFGDMTFVITLHTFGSPVEYELCPDGKHRQLTYENREEYVEMYWKYLLINSIEKQFESFYNGFMKVLDKDVLQIFQAEELMQLVEGEELIDWNEFERATHYKEPFNRDHPTIRLFWKVFGLFSNDEKRKFLKFLTGSDRIPITGVKSMDIVIQPMNVSDDHLPVAHTCFNILDLPLHYESENCEELMRNNILKACEYCIEFALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LD06</accession>
    <name>A0A922LD06_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">18S rRNA (pseudouridine-N1)-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">EMG1</name>
        <name evidence="15" type="ORF">DERF_001495</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Also has an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a pseudouridine in rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46696"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:13933"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LD06"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9527485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="288" mass="33213" checksum="5FD9AFC4A181F7AB" modified="2023-02-22" version="1">MDKKKIKKFNKSKNFKRKFNDDHNNDDAQHDSGGQDIETGENEQPTTTIQNYDHDNPDSMKNVTESKDKIFNPKRFKNVTNQSKRLIIILERANLEVVKNKQKFELLNTDDHQNLIKKFKKDPMFCRPDILHQCLLMLFDSPLNRAGLLQVYVHTEQNVLIEINPQTRVPRTFKRFAFLMVQLLHKLSVRATNSSDKLMRVIKNPITSHLPVGCRRIGTSFKCSNLVKPKDLVPKDDQPLVIVIGAMAHGNVQVDYTEYDVSISQFPLSAALACTKICSAFEEVWEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HGC7</accession>
    <name>A0A922HGC7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HGC7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="532" mass="59942" checksum="40DD496D8ED8C3FC" modified="2023-02-22" version="1">MNDDNDDGDYHHEDNHYVNQPNDRSRRPKQQLDRNEHRNRLISSVIDQYSNDDDDNNDLINLNHHDDDIYRTINNNEKNSSLILEHSTTLKNNHRQPHLHRAPSPYELETPKTYLSTGGGGGGSNGGGNGRSSSSSTITTPVIIHKYPKYESTPNKLMNTYVPMDYNTNRQINSKSLSSTSTLDKKLFNYGPLRQTTTVSSSYDGNISIDNLKPTTATYTTKLDTDNLSSYEIMKKYSSPKNAVDTSTTDRPLIDYGNISPTPISAHKGSSSTFTPATFSQLYIENQKASKLEPIPASYVRLVEQRQQQMQQQQQRNKPTTLKAFNHINEQLISLTPMNNKTEQYTKIGSNHQHHHHHNHGSVLPSPLSSSTLSKYEQLIAQSLAQNNNGHSTQISPNHYVTVASPIRIIEPTREISRSLINSNGKDQTLSSSTTIIDDNVDNNQQQPVKISFVNDNNNSKGNLKNHRLLSSTIANEQNNEQNTKMADYGTTNYKVVKQIKGKNLLIDPSLENDPERDSIIAQVLEMLNKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKW4</accession>
    <name>A0A922HKW4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_013047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKW4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380:SF173">
        <property type="entry name" value="CUTICULAR PROTEIN 47EF, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036826227" evidence="3">
        <location>
            <begin position="18"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9497034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="104" mass="11584" checksum="5664B5F70CB19117" modified="2023-02-22" version="1">MFKHLFITLFCIYLVSAAPTPEDEKPDPYSFAYDETDEYGTRLARQETADERGVVQGTYTYSDANGLTRTVQYIADDDGFRANIVSNEPGLTNSAPAAANYQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HL24</accession>
    <name>A0A922HL24_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_016037</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HL24"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="16">
        <location>
            <begin position="111"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9491308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="410" mass="48281" checksum="C56D8876926D1BDC" modified="2023-02-22" version="1">MSKKIMAVDSITTHRIGHKESGGEIRNSITKLSNNNDNDNYHSNEDDYHQPDLIPDDDDDDDDNEKSLRSDPLPILQLNDIVWRNVILLSILHILAIYGWFIFVMDPNIKWQTSIATFILGLFSSSFGITAGAHRLWSHRSYKAKWPLRLILAFANTMALQNDIYEWCRDHRVHHKYSETNADPHNSRRGFFFAHMGWLMVKKHSDVKLKGKNIDLSDVWADPIIRFQRRFYIPLVIICWGIIPTLIPFYFWNETLWHSFLGCVCFRYVYVLHCTWLVNSAAHLWGHRPYDVNIEPKENDSVVYLTFGEGYHNYHHTFPWDYSASEYGSYYNFNLTTLIIDLFEHCGWTFDLKKPSNELIVARKYRTGDGTENLLLRRKSLYDWLVGIFVTTSNLTITLMLRMIYQYLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLX5</accession>
    <name>A0A922HLX5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLX5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="127" mass="14252" checksum="5EE3361780DD3777" modified="2023-02-22" version="1">MNLPIWNCVVLLSQIYSGHSVWAANSVEDHIFSYNHVNKQSVALIHWACRYVDLPIELSSLSLLLFAAVAVDIEFERLVVTSLDSGVVENRRFFLLLFVLVVVSALEVKSNDDCRLEPGVESISFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HM47</accession>
    <name>A0A922HM47_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HM47"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7337" checksum="29A3740B65ABF6DF" modified="2023-02-22" version="1">MDNKRFVFSQSNMISATFIHDIRTAKESKFSNINSVWYGMSCSATFIRPMQCIPGKKIDSVSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMQ4</accession>
    <name>A0A922HMQ4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PRPF38A</name>
        <name evidence="9" type="ORF">DERF_015853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMQ4"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9491118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="354" mass="42221" checksum="C0646E1BE2EC6480" modified="2023-02-22" version="1">MANKTVKDAITVHGTNPQYLIEKIIRARIYESRYWKEECFGLTAELVVDKGSELRYIGGSYGGNIKTTPFLCLTLKLLQIQPEKDIVIEFIRQENFKYIRALGAFYLRLVGNPLDIYKYLEPLYNDYRKLRRMTKMGTFDVIYMDEFIDLLLREDRVFDIILPRLTKRFVHEENGELTKRVSLIEEDLDLDANHDDDGNSDDGKNQSDGKVSTDSDDEDRRRRHKKRRSRTPDRYGSHHVDNDDGDDRRRRHYHGSSPPTSSHRRNNDNDDYDNDRHSHRHHSRRQRSSSRERYDHRRRSRTPEKRNRDHHHHRKDQRKENREQEKSKEPKTEADEIAEMNALRAKLGLKPLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN22</accession>
    <name>A0A922HN22_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Palmitoyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Synaptobrevin ykt6-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">YKT6</name>
        <name evidence="14" type="ORF">DERF_013816</name>
        <name evidence="13" type="ORF">HUG17_0859</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle membrane</location>
            <topology evidence="9">Lipid-anchor</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN22"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="140"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7645321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9497862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="200" mass="23307" checksum="A95559F56EE49620" modified="2023-02-22" version="1">MVKLYHIGVLYKRENNSIICLRHASDLSTFGFFQRNSVGEFMRFTAKMIVERCELATRSSLQQQEYLCHCYIRSDRLAGIVISDNEYPNRVAHTLLSKILEEFTQSVPSIRWPTMQEGQAPYTKLDQYLARFQNPKEADAMTKLQTEIDETKIILHDAITGILERGEKLDNLVEKSEELSTQSKLFYKTARKTNQCCQYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN39</accession>
    <name>A0A922HN39_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_016041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN39"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9491313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="47" mass="5205" checksum="86324E914C40F7DF" modified="2023-02-22" version="1">MYFSKSKMKINSSIGQGNIVVYKPPPTPPPPSTISSVDSYVDNYYCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN69</accession>
    <name>A0A922HN69_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_016023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN69"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6286" checksum="F0019D379F9E340B" modified="2023-02-22" version="1">MDGSSKEMDGSSKEMGCSSKEMGCSSKEMGCSSKEMGCSSKEMGCSSKEMGCCSVDFIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNG2</accession>
    <name>A0A922HNG2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_014118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNG2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037599517" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9493366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="300" mass="35316" checksum="65671609E5371422" modified="2023-02-22" version="1">MLKFFLFLFISSIVFVSSANAEDTAIDYRELIKCPENQDSTRYLRNPYDCSSFYRCHVEDGKRLAIWNCPNGQYFDEDPNVQTCIRINDYLAKYHECKTIQKPTQRPTQKSTQRPTQKPITKRPHHHDYHNNFDIWKKIMDKMVHDLFNKNDYLQHEKYDAGDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDENDDDNNKQNHNQTNPILSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNI6</accession>
    <name>A0A922HNI6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNI6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8920" checksum="6E5200E5AB5C77ED" modified="2023-02-22" version="1">MDFFRDDDNDDAANFFFLYIVSVHEVQKLQTISTLERLSSSYKNNINIDIKILYIHCYRHQLYPQVPHQDQQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP10</accession>
    <name>A0A922HP10_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP10"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="153" mass="17657" checksum="2FCD3A7FC5B43BB6" modified="2023-02-22" version="1">MTCPIKLTTLAVIISRWTRMVKEYTQQISQIRYVPRKKKATTSWRTMSWPTPLVHLMVSNPQVLPDEERLNRAITPKLPIQLMRPFPDFQIEESHYLECRVNRSEPILNNKSCEALDVFGDQIPKVLKISITSQPTTRRSSDSSVEALSSDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPL5</accession>
    <name>A0A922HPL5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPL5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="99" mass="11658" checksum="0D03686326BDFFBA" modified="2023-02-22" version="1">MINQSMIVYQNMIDRFLSDIHTVAVPRRLHPDVVKRFLSILILNKKGNLRKIYAFCTSKCSKKTLTMLRQLEPLSIPQEYISTPLEIEKIQFLPFICYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQC1</accession>
    <name>A0A922HQC1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cysteine and glycine-rich protein 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Muscle lim protein mlp84b-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CSRP1_3</name>
        <name evidence="11" type="ORF">DERF_013810</name>
        <name evidence="10" type="ORF">HUG17_0872</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQC1"/>
    <dbReference type="OrthoDB" id="1679758at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042805">
        <property type="term" value="F:actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060537">
        <property type="term" value="P:muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7645334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9497855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="100" mass="10937" checksum="4707E4202723F3C1" modified="2023-02-22" version="1">MSSAICMKCTRPVYHAEEMLAGGLKWHKTCFKCNLCNKRLDSMNANAHDDALWCKQCYARKFGPKGVGFGIGSGALGMDIGEHLGNKECEVTNKPLGINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQY6</accession>
    <name>A0A922HQY6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQY6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="80" mass="9281" checksum="F9A9DF3B3A818BCB" modified="2023-02-22" version="1">MMDRCKFDHRQSFTFEGKRKSFLLRLGRSIVQLTTTTTTTVIFQGLELEKEKSGQVPIYLVLDKFLEISNVFDEIYSTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HR84</accession>
    <name>A0A922HR84_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein saal1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SAAL1</name>
        <name evidence="5" type="ORF">DERF_010906</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SAAL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HR84"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052464">
        <property type="entry name" value="Synovial_Prolif_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23424:SF23">
        <property type="entry name" value="PROTEIN SAAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23424">
        <property type="entry name" value="SERUM AMYLOID A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9506163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="378" mass="43671" checksum="2616A99C50E8DF94" modified="2023-02-22" version="1">MDANAIGQTFVQNESNTTSNHNNDDGDNDEPSSMTMSDNVTLIDVEDQLCLIWDISSETDVQQCLYELNADEIFINTVMRTENRRLAEISIGILGNLSHNDRISERIATNESFWLVTKHSFALSMFTAADIPFLIQLIRFLHINVHKKPEKWLSLIHEQRKFFIYQIEYLMANCLNVELLRLLLQYLNDVLYRDEELASQVLFTDDDDSNFITALCQACQQILTEIDDQDNDEEAIDTNRDVQFFHNFWFILEMVTRGINIDGHHRLPDCGNISELFIRFATGQSFIDFESSNSINSFSAACACLIRFIQQSDDVKNPKNISTIFQQTMTIDRLKLTFNKSLALLSDQQLPIHQDDDGLILRNLHANIDHLYRYLFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS16</accession>
    <name>A0A922HS16_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_013854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS16"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF496">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="632"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9497914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="837" mass="96861" checksum="6B0E06F945D9567D" modified="2023-02-22" version="1">MHPPPPPPTTTTKDRNDTKPSLSVANFYGLQPEGLKNTQHESSSTTTAATTTSPYDCYVFVIYCPNHRKVAISKPDDRPIVWLPFTTSLITSIIDDYHYTDNAYNGVMIILTDNNENQMKILRQQNHPQPFNQCQCIEIFRLQSPQTSKFVVRQTYFVELNGSSNQQFVCCQDNKHVKWIAVDELLNNYVANLWGPELIQFLRQSMKKPILQQIQEYSLEKAYHFLPREVPRNIEESILRSARLTEKDVERLYTDFVEHCYPSTYQTFESFRCYMEKFGFNRRDCRLNSLFNAFNFKNNGFLSFHELLLGLATIEPDTVHGEWRVRFIFRYYNNNCTGNLDMNEFQKMISDMNPGLSSSSSAESIDLKMKQSANEIGTKIVNGKTVITCDDFVLAIGQHRFRGTSSLCRSTKSLFLQISRAMAAKALKKSDKFHNIESIIDQFQGICLNCKEKQYRLACHSIKLDSNGSIIDVSQIINYHNNQLKSPEELAAINYSNEFQFNMESSAPNLMIKLIREFHPNKGTNKKPNGLLENDKELLWKLITALCNDMNRLLDHEDRCVRILSPCYVIGDIHGNLDDLLTMEQVLWKRIPCVGSNFLFLGDYVDRGQWSVECCLYLMAFKILCPNKVTMLRGNHEVRSLQIFYSYKKECLRKYGETMGEKIWEITNQIFDKLPISATIDGTIFCSHGGIPKSAKTLQEINQIPRKLPEPEKESPIAWEILWSDPCHQQQFIEMCNFFDIDHHDTNGYLNNIRRGTAYHFNEFATTKFLANNGLTKMIRGHEVPQQGYQFHFNDGKCLTIFSSSHYCGNQNHCALVLIDQQQQIVRIIRLDTYNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS66</accession>
    <name>A0A922HS66_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Solute carrier family 13 member 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_011021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS66"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015556">
        <property type="term" value="F:C4-dicarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9506281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="61316" checksum="8821B7BF1B546A1A" modified="2023-02-22" version="1">MDETVVNQTLARLLAHAVRLVAVVGCRWAAKRSPMRLRGGGDDHLLVYRGHSDGHHVINTGGPVSRVADHVDRQSGQVVFQRNDGTIMVFLGSLIAATAVSKSNLHERIALKVIMLTGTSPRRLMLGFIVTTAFLSMWISNLATVAMMLPIANAALDQLERRQSVSVATNDTVFVTIGAGDHVRSNSITKTSTVAESRKNESKPLHKGILLAICYSANIGGTGTLTGTSTNLVLNGFLKDDPISFSDWFFFNFPTLVLLVLATWLFLTCFFVHNSSSSSSKLGSKMEAKRNEKQVLEALRQQYDHLGCIRFNEMAVLILFGMLLSLWFFRAPDFMHGWSTMFSDRNNSYIKDAVPTIFVVLLFFVIPADPRNLAQSPMLLDWKTTREQVSWSVMLLLGGGFAMAKGCEQSGLSAVLGDSLYMLHQLSPFAITLIMCSVSMTLTELVSNTAAINIMLPVIHQMSHSMKTDLNPLSVMLPVTVSCSYAFMLPFASGTNAIIFEAGKMKTKDMLIPGFFLKIICVLILLAINSVWAPVIFQLGDGGGGDNPIMFSSSSNQTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSR6</accession>
    <name>A0A922HSR6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HEAT repeat-containing protein 5B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">HEATR5B</name>
        <name evidence="3" type="ORF">DERF_013950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2017"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1206"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2039"/>
            <end position="2053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9498023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2065" mass="232477" checksum="200E8F74487E9CE3" modified="2023-02-22" version="1">MASQSDYLLNETEFHKLNGEKKIIYVYDWLRHLSKLLHKAEKDDIKDIQKTLVDQLIKQLFSQNGNPSRRLIAKCLAMIFTVGDTFLLFDTVNKFIETLKNKDDSAVISNSKLSSIICIGIMYENLGRLMGRTYEETVQSLLKLLKNVDSQTRFEIYSTLRMIISGLGSAGNSIHRDVYKSLKHGMLDRSMSVRANAASCLQKLIEVASFLYTTEIENVFSLCFRALDGSNYEVRLAIAQTLGTVVAITQTPSIRQSLQSLQISANSTKVKIFTLEEVLNLLASGFLRGGIGFLKAGEMIKGSSTANREIRIGVIHSYVDFGNRMGYEWIERNSPVLLNHFFEILSNSKAVSTHLDAIHSRRCITFILKMIISTYITEKGQFMAIKELVKIMSQYSRVGHVMSTNPKSQDSANAEIEKNSVIRNSIDLQTAQHILVVCLLEIGTLINQLGASCLAILNDTHLSLIDNVCFVINHPAHIVRLSAAWCLRCICLAVNSQLTPLMERSLERLETLRTSPESINGHSYVLSALFGTVRYTPLGIPQNKTKLVFNIAEDLLRTASQNSRLSMPRTQAGWQLMGAVLSLGPGQIKNLLPRLLLLWKNSFPRNTKELDSEKARGDAFTWQITLENRAGALAAMSSFLTYCSKLVTDEIRRRLFTPVESAIAMLVSLNSHFKTLGPAIKGSYTMVRLRLYQVLLCLPPQLYENCFANLLRLLVSDLTLTENVVNTSSSLIRHLIQTNADIILGSWIQDTEHSLVEDQIQNHLSSGVGSIEYDPTILYKSANDPLLVPASPPLAVAVINKSAQVFALVFPYVAQKHRVQMLNHFQECLKHAKSSRQEAIQINILTAMLGALRTLVENKINLGIDEVRKLVVAQLFNVLDHQNILIRYAAAESLGRCVQTINDAKFLSTITQQCFEKLRTARDALTRTGYSLAIGCIHHYVVGMGSVPQLKNNISLLLALAEDHSSPSVQLWALHALTLIVESGGPMFRPYVEPTLSQCLKILMALSPSLIDIHQSIAKCLSAIITTIGPEFQTSSTHSINEIRLMIMIACSILQEHGDFLIKSETIACLQQLHMFDRNCYELNELIFILCDGFISSRYLLRKASICCFQQIAQKDSKALIEYGSEWIGIISNFNLRANHQFPGILVALLDYETNSSNMNNIKKILNCLVQHVDEKNLNLWITLCKEVLSASDAGSSTIDSNENDHDADDGDFEESGFKSNHNDSLNVKLTYRWQTRVFIMNILYKIISTCSQSLNDAAIHFDLNMAREKRLKHQDQDFLCLHLPDLVRMSFIGATSDCDQLRMEGLKTLELVIDKFAHVPEPEFENHVILEQYQAQVGAALRPAFAVDTPSHVTAMACQVCSAWIGSGVARDLNDLRRVHQLLVSSLEKLHKHSNSKIYNESASTMEKLAILKAWAEVYVVAMLRNKQQQQEEMKSPSVTINSESLLDLVQPQLLTLSKYWIFALKDHALLTLPDEYYSQIPPDGSTFFNLETIDIVRPMYRASWPSILNAAALWLCCSDKGFEQLENDTSLNLSRFEQFYLLFGVCIESLSNPKSTEQVAYVSTYLDSLKELITHNEVTESILSKDTQLILELSQVLHRLLLTHEVSGCQLVITEIIKSLIDIQIRMKRDGNESNKSLSSVTGIEAHKSIVYSILEICLAILVRQLPQLCPQLAKTPEFCFVRSQKSTNYFQLFNNDNAKIIANVLQILSDLCNVCQPVDTVAILPTILYLIIGVFCELSVVCQTVYDEKLYEKQPIITFLKCIKNLCTSPMLMAHNDNDEIRLKWIQLLQTAIARILDLSKTSGGNDDQKQDFISTLLAIGVFIIHSPEEVLSHPQIQYPIINLMTRALKSENELVQLKCIETLKSVFTIQNNNQSNFYIHNLAAELIDVYYSLTASFRMNQSLSTNRITSMINILACLEILVSKANDEKRINMLYIYIPALISLLNVDPPSSSTELQTNPRLLSQSHAQKIMIHEHSLKKLTEIGPKYPHEFKQIMNSNTTYSDCLKKAIHHQGRKTTTTTTNLHDTMDNDSKMNSSLSQQQRNSNENQTIKLKVDFSNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTA3</accession>
    <name>A0A922HTA3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">DERF_010759</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1340.10:FF:000001">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000025">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000018">
        <property type="entry name" value="Histidine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="10 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="17">
        <location>
            <begin position="105"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="16">
        <location>
            <begin position="567"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1537"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1537"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1572"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9505999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1581" mass="180525" checksum="8ED778E1F712A4B7" modified="2023-02-22" version="1">MNNIIHTNIDSESGGSASSVEKNSFTSEDKLKSSEFRCRITFVRSHLWSWILILLCLIFILISLLIGFLILTMRSQHNHSSLCLSVDCITASAEMLTSMNSEIDPCVDFYEYACGGWIRSNSMSDDESRADTYSVIRNQMSEKLKLLLEEPITTADSEAIRKVKNFYISCVDLKLIERRGERPLLDLLDNEFGGWSLIGRETEKLSSMDWVTMMGTLRQYNNEIIIGHNVGPHDANSSLHSIKIYPGGLGMSSSDFYLNKSSKNYQSYRQLMVKTVNLLMQPSSSSSQQHQHHHQHQSNETIQRINTDIDDILEFETRLANISSMFEKTGGAAYQRMQVNKLAKLVPRINWQKYFELTIPQPLNDTESIGIFGFDYFLDVQDITQTVPERIIKNYLLWRFVMNRIKNLDQRFENILEDYYRDQYGTKSIPARWKKCIEFVNGNLGTAVSALYVRKYFDLESKQKAEGMIKNIKKEFMLILDEVEWMDDETRNDAKKKAEMMEEHIGFPDYILDPVLLDKDFEHLEFENTTYFENVVGYLRNSTTKSQAKLSSVDDRTKWTVMPSVVNAQYHRFRNLMSFPAAILQSPFFNKNYPPALNYGAIGSVIGHELTHGFDSNGRHHDQFGNQRLWWHPNTVDRFIKKSSCMIMQYNNYTVKIHGDTLNANGLLTLGENIADNGGVKQSYRAFRRSLLQRPNEFYLPGLNMTHDQLFFLKFAQSWCQIMTDEGMVEALKTWRHSLGKFRVIGTLSNFAEFSKAYECQPGTPMNPREKCECRSFLNGTSTTTVVATANNNNDNDNKTVDSDEENDEDIINRQQQQNQSQKIITIIEDENENNFINNNWKRINKTKSSSSSSSPPPPTSQSMMMNLNHAEKFKCLFNDLQENFKNFTTQLHSPLSSNQTTSINNDCLNNNNNNDDDGDDDCDPPFLDHHRTTIINGRQKIKCKQQQPSTPPGTCMNTEEFRRRGKEMVDYIADYMETIHKRRVTPNVEPGYLKDFLPESAPIQGETWDHIMDDFEKLIMPGVTHWQHPRFHAYFPAGNSYPSILADMISDGIGCVGFSWAASPACTELEIIMLDWVGKMIGLPEQFLCFSDHSSRGGGVIQGSASDCVLVSLLAARCAAIKKLRAKDGIGTNNNDDPVIDDGSLLSKLVGYCSKEAHSCVEKAAMIALVKLRILDTDENFSLRGHALQEAIEEDKRNGLIPFFVSATLGTTSCCSFDALYEIGPLCSRENLWLHVDAAYAGNAFICPEFQYLMKGIEHASSFNMNPNKWMLVNFDCSLLWVRDRFKLTQALVVDPLYLQHSFSERAIDYRHWGIPLSRRFRSLKLWFVIRNYGIEGLQRYIREHVRLAKRFERLVRQDDRFEVVNQVKLGLVCFRLKSSDVTNQKFLSTVNASGKLHMVPASLNGKYVTRFCVCAQNATDSDIDHAYTVISQFATDLFEIIEMEDKKKQPLSTTMTTTTTTTTATNDIDEETVPITVKTDDNIATTNIEDNEAVDEVFMLDRKRQMSLRYKRSFFVRMVSDPKLYNPKIVKALNNTNSSSQSSLDATTATNPIANNITNDNKRHTSESNEPPPPPSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUD8</accession>
    <name>A0A922HUD8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Mitochondrial GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MTG1</name>
        <name evidence="7" type="ORF">DERF_011353</name>
        <name evidence="6" type="ORF">HUG17_10683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000006">
        <property type="protein sequence ID" value="KAH7640203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUD8"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000004">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="32"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="166"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7640203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9506629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="348" mass="39848" checksum="A8E9E678EDEB9082" modified="2023-02-22" version="1">MQTSKFLFSSKFVARSTFQVDHKLQWFPGHMRKGLRDIGKVLRRTHCILEVHDARIPFSGRNLNLIKRLVSNKPIILILNKSDLLSAEFRPLIRSQLMEKMYKNDIHLEDIVFLDSIAANVKHAGYSNQFLSIILNSIEKIPNTIDESDFSTEEKSYNLLVMGIPNVGKSTIINRLRNVYLNKAGKATIIGAKAGVTKAVLERIKICDYPHKLYLFDTPGILEPSFNRNENNPTNSPEQFMRCALCGTISDEVIGKELIADYLLYWLNKQQRFDYVDFLGLPSPTNDINEALTHAAIKYNQFRPFKNLETGVQELKPNYIPLAEKFISEFRKGNFGHVLLDIDIIKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUR8</accession>
    <name>A0A922HUR8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Two pore calcium channel protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TPCN1_3</name>
        <name evidence="1" type="ORF">DERF_009805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUR8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022832">
        <property type="term" value="F:voltage-gated channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028801">
        <property type="entry name" value="TPC1_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46474">
        <property type="entry name" value="TWO PORE CALCIUM CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46474:SF1">
        <property type="entry name" value="TWO PORE CHANNEL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="8262" checksum="E9C203695C6F3D53" modified="2023-02-22" version="1">MLAVVYNSFSQIEKDKFCKLFLHHRKACDHAFCLLVAVNKNAIGYIEFEHFNGLMNHLKPRSSQMERFLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVH5</accession>
    <name>A0A922HVH5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylation factor-like protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ARL15</name>
        <name evidence="5" type="ORF">DERF_011689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVH5"/>
    <dbReference type="OrthoDB" id="365445at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042292">
        <property type="entry name" value="ARL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46693">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46693:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9506984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="226" mass="25563" checksum="27068B72A6F77765" modified="2023-02-22" version="1">MHVLCCVSNDRRKEMSGVRNAFNCSFVACRSNLRKCWHFILCYKPQLLSSSSTTTNEHQYQVLCLGLSGSGKSTLLAQLVGEQIGVDTIEPTEGFNIKTLPLNGIMLSIKELGGSERLQTFWSNYYENKHALLFIVNIASNETIMQQSLDTLRTILMNPGLRGRPCMIIGTHKDRPEARTEQQIEQYFQPLLNGHKWKIFCCSALDRKSIMDAFAALIVLIKNVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVU3</accession>
    <name>A0A922HVU3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Menin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MEN1</name>
        <name evidence="11" type="ORF">DERF_010804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14456">
        <property type="entry name" value="Menin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007747">
        <property type="entry name" value="Menin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12693">
        <property type="entry name" value="MENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12693:SF3">
        <property type="entry name" value="MENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05053">
        <property type="entry name" value="Menin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="170"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="444"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="531"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="589"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="705"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1130"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="466"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9506057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1316" mass="147147" checksum="C03B68CF56025593" modified="2023-02-22" version="1">MTAMINSCDTNQESVWNYTAAATTTTTTTTAAATAITIGNLETKTRTSCNSSSNNNNNNSSCTNTNNFNQQTSSSINSSRNTLSNFVNGKSSGGDDGNIINESTTTTTTIKEKRQNQNTEINKCSNNNNKNDNVLEKFNSSALMNHHDYDNNRLQTFDELLNHHIHELSSSSSSSTSCYCSSNNNNNSLNHKSRKKSKRPRQQQQQQKRMTAHNNNAGVLYNEQRQQKQQQHHHHQQQQQQHRKRSSSTKSIVVIDGGNHNHHQCNNNVDDDDDMGGNNVDAGDGSYVERNQRQNLGSRHRQNSRRTTANHHFNNSSISSSSSSSSLIGHSSNLRHNNNNKLNLQTKQQQTNHIKLSTNNKNNNENENKNIPVTSGPITTTTMNLRNRTLKVAAIATATATVTATTTKTEHQPSSNISTLATCPTQTTLPTNSDTIIIKNLTTKINNDNHHSGQQQQQQRRRSNRRQNNNKQADLSIDSKQSEQQQQQASLPLSSSSSSTTTLNSSRSIRSFFPLRTIGAVCELFRSQLDPGQCNDNDDDDSDLISNRHHHHHHHESSNRNEPDLALLSIVLGIIETSLTRGLYIDHTESSSSINNEHSTTTTLSDSHELHQQQPSMTNDSNERNSSTTMNDDNHHHHHGSYSPAEASIAPIVPIVSNIIHTPLDIPIPTVYYENVESLLKKFQQHIKESIDLDKCVTDVVIEKPNNDDSCNDDNGGSNSNHDSKTTPTATTNNYNNNNLRELITKISELIWSNLHRSHYKDRAHLQTIYSYVSENKLDCYGVAYTVLAACQILGLDDVRLVMSEDHAWVTFGQGETCEVTWHGKCGNDDRCGQSIPSQMESLNCWLYLNGNTMICDRFQTIATLVSAMNLSINATQDSEELAILQQHLLWILYDYGYLERYPMALGNLGDIEDVCSIHSTTARKHPLELFNEAIESAKKYYNDYHVYPYTYLGGYYFRKRQFKQAFQAWADASRVVMKYNYTRDDEEIYKEFQEISNDLIPYVVKYSTSVATAAAVGNDDDNGRIDSIIDDPECFVHLLRFYDGLCAWEEDSTTPVLHIGWTKPIVSTISKFPYRTRSQIIIKVDPTLNVKHQFNQSSMIGDGDHQDDSIENSENHNINISGSIVVVASGGGGGGRERRRRRAASIGQQQLPPATPPPPVVMIKQEINNSNGELNHTEQMKQKSIEKMDCIDNQDENDGKIVAILVSKKFSGIKNLLTADKLNTSAIQLQLTAQSQVNIFNHGKRSGGGASNRLLVGSGKSIGQFSEMDYIVSTTTTTMNSSTTTAVGSGQTRTNNHHTIINQQQNSSNKRLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWF4</accession>
    <name>A0A922HWF4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWF4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="116" mass="12416" checksum="56F0CC289AE34747" modified="2023-02-22" version="1">MAKSPLKMKNISLKDPSLLINSKSPSKTTTTTTATTFSPATTTKELINSNQITTALLPETSDIPSKRYIVSQGTTKTIGDEKMEKTIIGIPDEKEDESITARSVTTTVAVTSPNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX12</accession>
    <name>A0A922HX12_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_006858</name>
        <name evidence="3" type="ORF">HUG17_1409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX12"/>
    <dbReference type="OrthoDB" id="6498020at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="46"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7645871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9516096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="225" mass="25986" checksum="DFB7F1D460842492" modified="2023-02-22" version="1">MGSIIVNIFSFTTFIIIIISISVASQPTSINRHYYQLGFATNNIVSKCDFLTNSCRFRNQHNLATYNRYYNAEKMFFDRHSLLLLNINAPRSQRYPGARLITPYYQAKYHNACLFVSYRYSGPGTLRFFIIQQDIDNKCIFSDDHFKSSISISNENVWNHLELQLDLSDGDVRFFLETHFNSSAKAGYFAIGDFNFGYGNCRNKNENHCYDNIINSHINVAPTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX42</accession>
    <name>A0A922HX42_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FIS1</name>
        <name evidence="4" type="ORF">DERF_009666</name>
        <name evidence="3" type="ORF">HUG17_7520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX42"/>
    <dbReference type="OrthoDB" id="6511252at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7637314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9511196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="155" mass="18102" checksum="3E34800C12712EDE" modified="2023-02-22" version="1">MIYNDETLLNNKVSESEVQKIVEKYGKAFKESRLNPSQELEYGQVLLQSPFEQDLFIAITIFEELIRNRRNELNMVLEYYVGLIIGFMKVKKFEDAIMKLDLCRQLIHLNIEQENRLKMLENRIQNRNRSFFWAAASFVAGVGAIALMVFSGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXG2</accession>
    <name>A0A922HXG2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXG2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9515838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7466" checksum="83A8F756F49DBCDC" modified="2023-02-22" version="1">MECLVELASQQQLKYSFAEYPEYHFMFMCNEGSHIHDSESSSQRKKNVIGHILLDMLYPYMLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXL7</accession>
    <name>A0A922HXL7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXL7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="195" mass="22390" checksum="485529CDF16276C2" modified="2023-02-22" version="1">MTTTATTLIQHTKQQKSSKSSSSSSLQRILPTKHPLINNGTIIDDNIDTNNNTNLMCQILEYFLRNFIKKSTTTTMTSTTKLPLLWPSMLKPPTLSNTNMSSSYSTTNTSTHQNHYHHHHHHHSSGRQRSLSSTSSFLLSTSRHHKHPHHHHYEESMVANNQHDNHHYNRGYTHMQGVICTKPNIICWSPYMVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZC5</accession>
    <name>A0A922HZC5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZC5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7709" checksum="629DC58255A723A1" modified="2023-02-22" version="1">MEKTLKTILKVFHFSQNSVPRIFDDDNNRPDLTIRPFDHTVPYEPEYHQKQQQQQQQRQQKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZX2</accession>
    <name>A0A922HZX2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZX2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="9642" checksum="2633ECF61A4F09E6" modified="2023-02-22" version="1">MDLPTEYSNATKEIGQANDNIDGVSNMKMFIYTRITTPFVEDDMKSDESHSHSKEFHFIFNMFDTCSSYQYILVRLSTEKISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I089</accession>
    <name>A0A922I089_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I089"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="92" mass="10510" checksum="E6693F7F98BFC64B" modified="2023-02-22" version="1">MKFSTISSYDDYLVLTNVNQYVSCYDKFHLAVYTADFRLCVSVQKLIKLKTSGPQSQVVLKRTLDGDIPPAQLLIAKGNHVKFYFITMASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1W5</accession>
    <name>A0A922I1W5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_007728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1W5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="586" mass="65835" checksum="124044616FC25C9E" modified="2023-02-22" version="1">MITTTANENTSSTESLSKAVTSYVQVVPMINEEKIEPFSTTARTTIIKPALTSTFNRQNIPKIDNKSWQIPTSTVRSSSSHHQHHSVGPATLKLTDANYRNGSIHLRWETLKPSILGYQVLHRYFGSKEFYRSELLIPLTNSYTIDKHVKQNELIIVCVVNLDSNDPELINYDEEGENIIPNGQCRELSTREPIVKKTMPTRTGSATSTTTSLSSFYPTLKRLNDIDKIVIGISAAVCLFIIIAVLIFSCCFYRSSSKDSPLRTLSTNATCLSTKSLSPLAKSSFDHEWETVSVYSTRSIPRARITHTMPIGPPPTIQHTDTLRSYHHNGYTHPVSRYIGSTLPTPQKSPNFHSPWLESYLHHYPSVNHMHAISYGTLVTANGGGGSSLIPYGSAHNNGVAYSMDTFSNHGHHLVERNKSSSNNINHQKTTQSSKSGKNRQQSQPQQQQRQQYYKSHIDLRSNADSSNGSSSNRMLLSSTSTTSNSYQSQNDYDSDHHHHNQNHHWNNNHNHHPQLQLQQQQQHRTMTPALKNSSSMSPTSSSSMATTTNTSLNNNNHPTTATMMMMNNDNEVDIYIDQNYAKRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2A6</accession>
    <name>A0A922I2A6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">28S ribosomal protein S7, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MRPS7</name>
        <name evidence="5" type="ORF">DERF_007470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2A6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="65"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9516751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="215" mass="24787" checksum="51B964CB10B9C2B3" modified="2023-02-22" version="1">MVFLNIIRFAVARNSKASSLAVKKSQLVIQPLIPASRMNLDECSNLRDRDIPAARPGYPCSVGTRKGQRVLMRELMRETFMIIKRIQLTKLNSGNHNDGCDDDDQSKEVVCDPLVIFHGAIANCMPLMITRPVKRGGATYQVPFPISERESEQLAMRWLFQTIVERPKPRKQFFPEIMARELIDCFYNQGKVVKKKQDMHRQCESNKAYAHYRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2R3</accession>
    <name>A0A922I2R3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_004627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000027">
        <property type="entry name" value="Plexin A, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001407">
        <property type="entry name" value="Plexin A, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.506.10:FF:000005">
        <property type="entry name" value="Plexin A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF70">
        <property type="entry name" value="PLEXIN A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24479">
        <property type="entry name" value="PSI_PlexinA-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="6">
        <location>
            <begin position="186"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="7">
        <location>
            <begin position="237"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="7">
        <location>
            <begin position="345"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="7">
        <location>
            <begin position="432"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1214"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="742"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1214"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9520951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1513" mass="170663" checksum="1195F9C0FDEDFA35" modified="2023-02-22" version="1">MDSFTAKLSVRMRDGPDFVATNFTFYDCSSFTSCTECVSSLFPCDWCVGGHRCTHDTGEHCRNEILVTGIKSMGRSIRSGPSFCPRINSTVSGTTEVLVPNGMSKRISVKVVNIPQAITIRFVCQFNIEGRVKQVNAQLLSDTIYCESLQFNYFTNLTNITAEFAVIWDGNKPLDNPDNIHVLVYRCSGLANNCGFCLELDEKYKCGWCQQSESCQVQEQCQHHNTMWLNRQQICPNPRILDFYPKTGPYEGGTNLTIEGINLGRIFKDIENGIGISHELNGQQISLIPCYPYRNDYLKTSRIKCRIQGRNMSADPSMKSISGPVVVQVLKEYTAKSRDHYMFVNPKILTINPSKGPVSGGTLLSIEGLNMNAGSSASAFLGDLPCNVTKREMNHAECITSARLMPGEELLSVHFDNGIRVFEYYNYLYAEDPKIESVTSESMSTSTNRIIGPHKQLTHVSTSLDPSTMIQRGGEQQQPKGIPSGGFHLRVRGQNFNIIQEPKIYVDVDGEWFVSNCSVLNVEGTDMRCETPAVPIERLHFTRQEYIELDYGFIMDNVHSVRSLTIPRIGGGNRDHPPFPKFRMYRLPDFHEFSESDRIKYYRGEYLTINGNHLDSIIQSSDVNVWIGSERCNVTSFSQVQLTCRLPAQRPMAEDENYHQTYDQLPAVIVGVGKRFNKTLGFMSYDSSSSGSFFFFSSGSSSGALYKHVFIAIVVAICFLFVVVVVILILYRRKSTESSRVLKTMQEQMDVLELRVASEAKEAFAELQTEITDITAEINIGGIPFLDYRLYTLKVLFPNENNNHAVLKELALDPNERGHIEQALTMFGQLILNKTFLLLFIRTLESNRYFSMRDRVNVASLIMVTLQGRMEYCTSILKTLLADLIEKCIDGKSHPKLLLRRTESVAEKMLSSWFTFLLYKFLKECAGEPLYLLYFAIKHQVDKGPVDEITSEARYSLSEEKLIRQQIDYKSMTVYVSIHQAYAPPNYFTTTTSYDQPYGQLTTTIGAQPPQSAPPPPHMGPLAQLILTGNNNNIYGGPDSPLYNHHYHHPLAPQTANVQQQEYLTVPVKVLDCDTISQVKEKSMDTIYRGVPFSMRPFRDDELDLEWRTGNSGKIILLNDDTTSRVSGEWRRLNTLAHYKVPDCASLLLVPNSKQLYNSIDYMYGPGGGGIGAPLSGAIMSEKIGTLGGGSSSSSSGFATDKHRYEPLNFLKNSNTSTGGLLGGSSSPPTSLSRPTSPPTNHHHHHHDHHENNGYHQRQWHLVKHHDADHGKEGERGNKMVSEIYLTRLLATKGTLQKYVDDLFETIFSTAHRGSSLPLAIKYMFDFLDDQAKHHGINDSEVVHTWKSNSLPLRFWVNLIKNPNFVFDINKSPTIDSCLSVVAQTFMDACSTSDHRLGKDSPSSKLLYAKDIPIYKEWVERYYKEIETMPAISDQDMNAMLCEESRQHAHEFNANVSLLQLYQYAFKYKDQLLQILREDEFSCRNNLPAKLQRVYDTMDSSGATGNASITDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I362</accession>
    <name>A0A922I362_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I362"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9518220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="56" mass="6692" checksum="69B79BE4BB9D7098" modified="2023-02-22" version="1">MHVCVSSLSTFSHNIIHYNHNDYTSHHRLYLWQEFFFTLAGTILPFETSQVFPYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I472</accession>
    <name>A0A922I472_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Serine/threonine-protein kinase stk11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">STK11_1</name>
        <name evidence="10" type="ORF">DERF_004880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I472"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14119">
        <property type="entry name" value="STKc_LKB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001234">
        <property type="entry name" value="Serine/threonine-protein kinase par-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000235">
        <property type="entry name" value="serine/threonine-protein kinase STK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039154">
        <property type="entry name" value="LKB1_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF8">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="721"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="521"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="750"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9521207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1119" mass="127736" checksum="8350DAF430E94C0C" modified="2023-02-22" version="1">MDLERIAVAGYQFKNWSGTYQCEPELFFIPETIDEIREILYLAKTEKKRIRVVGCGNSPSDLCCSSDYMISMERFSNILYIDRQQCLVTVQAGIHLDRLNKLLEENELALPVLGSISESALAGVISVGTHGTGYQTGIIADYVVAMRLITPSGDIISCSKESGTQHNDVFNSVLCGLGALGIILEVTIRCEPKFFLHQLTYPSRLDYVLDRLDENVESCDHFRFLYFPHTDYVSVSITNKVKGAFLNLYKSEQPYEITDQYGVDLVNQYRLHSERDMLQKIFDWIIKYGVGYHLLQFAYWLSTYAPAIVPTINRLAFWLLYSSNQVQMDISYKVFNFECLFAQHVNEWSIPRNKTSQVLRELKAAIDHGGLYAHFPIEVRFVQPSSIYLAPSYGRDSTYINIISYRPYGRHVDHTDYWNRYEEIMKRNGGRPHWAKNHRETAVDLVRMYPHFRYWAHIRKRLDPNRLFFNSYLDRIFSTFPTSTIATSDHNESKMFANVQGGDDRPINRFLTNRHTPHIYKLRMSTTPEYARASDDDDQRSESTKRVKKKLSCTSDNKCQVDLIVPNDNNNCDMNKSSDNPNNRDKQCGHTSPSSSSSDQGHSAKIPAVTVSNTATIPIIQLAHDDNDDEKDVCDERRPLFVTPPPITEEEMLDGCLGADGFLYEKSLLFEHEPVHGVSATGGSAIAAVSIQDKPLSYHRVNSSEILYEKKRRKVKFVSKYLLGDVVGEGSYSKVKEVLDTETLERRAAKIMKKKRLRKIPNGEQNVQREIQLLRKLNHENLVKLYDVIYDDVKEKMYIIMEYCVAVLQELLDSVPTTKRLPIHQAHGYFVQLVNGLEYLHSQGIIHKDIKPGNLLLSNGGVIKITDLGVSEMLDRFQQDDMISTSQGSPAFQPPEIADGRAKFSGFKVDIWASGVTLFNITTGKYPFQGDNIYRLYDNISKADLIIPAEMDYLLSDLVRAMLCKEPDERISIQQIKQHDWVRKKHPRIEQPVRIPCKPGGDELRSMSVLPYLWQLHNGSCGDELAVYDDDEEFEYATVSASDTTEWSNSRMNELTVNSFVSNASRTSKQSRASTISTNLASLFKLHKSKSARSQSTGFEALTRTNRFLNCLGLRSSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4Q0</accession>
    <name>A0A922I4Q0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4Q0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="171" mass="20697" checksum="81908D77C6543450" modified="2023-02-22" version="1">MDWSFFSTVAEYYSSEDTSKLKEFIDENWNKWYRSDTEKDIKQYYRCNKVKKNDIQCRARIFISYDKFSESIYLYQNNEDHTCSEIISTSNRLTKELKNKITSMYEEKQKPKQIYEKLKGEGNVLKQTLFGKDFRFLLSERLTKQKNSIQSLCLFALMNQEQVFSRLDRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I559</accession>
    <name>A0A922I559_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I559"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="203" mass="23743" checksum="E6235830A092A103" modified="2023-02-22" version="1">MSPLSASIIAASSLIIILIIYNHSNVDASMNKQRESLSNCKHKKLDQCLQYIISVTNNSRLSFPITYPELQRTCQLLEYGDHCTQNYLDKCMPRSMNKMIWNIINGTRNVLQLICHNLTIQNDYLRYASCFKRTTVKNCWQILNQFRQLSTTNNDDNDIQQFCCIYKSSIECQHRSILNDCYINHHHDDGSIKFFSTIFNRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I571</accession>
    <name>A0A922I571_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I571"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6513" checksum="AD08685BB183C87D" modified="2023-02-22" version="1">MSSVEKCGIVEFEFEAFVAVQFDDDDGGLETSSLVSSYSFLDYDVRVDVVEYGVLLGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5V0</accession>
    <name>A0A922I5V0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Vesicle protein sorting 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">VPS29</name>
        <name evidence="16" type="ORF">DERF_005543</name>
        <name evidence="15" type="ORF">HUG17_3475</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the Csubcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos. Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to snx17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves Cand WASH complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5V0"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000009">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7639442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9521930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="182" mass="20579" checksum="3C13BA33B39ADA8F" modified="2023-02-22" version="1">MLVLVIGDFHIPFRKHSLPSKFKKLLIPGRIQHILCTGNLCTKECYDYLKTLATDIHIVKGELDDTNYPDKKVVTIGQFSIGLCHGHQIVPWGDDESLAMIQRELEVDILITGHTHKFNAFEKDGKFFINPGSATGAYSALENNIIPSFVLMDIQSTTVVNYVYQLIGNEVKVERTEFKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I669</accession>
    <name>A0A922I669_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I669"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="8066" checksum="1521A4996A6123C6" modified="2023-02-22" version="1">MLTIIIVMSTSNIYSFKYSHRIHTNIRNRKKESKAKKKIHQFKVQSSRNQNYCSSLSANLECPKFEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6P8</accession>
    <name>A0A922I6P8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6P8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8894" checksum="CE0B3503AEE0C89F" modified="2023-02-22" version="1">MLYQSNLHSQFIREKNDEKLSKDFRLNKIQEDIKREKINSCMNVMNKINDKKKYDVIVVNINVDQMKIKTTYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I717</accession>
    <name>A0A922I717_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SET and MYND domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SMYD4_1</name>
        <name evidence="10" type="ORF">DERF_005502</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I717"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="103"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9521880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="726" mass="85970" checksum="895919E76D6B4E32" modified="2023-02-22" version="1">MPKFNLANDSNAVNLLQQLYDEEKYRKESSPMTNEKDGFKMMFESVRKHAVQIRKLGKKIQKECDLYEQKHCKQSTDESMPSIVGSSDNRYDNKSAMNFHLNKKCHLIQSEQFGRHFIANDSILPGEILLKERPILFTFYEDHRKTYCHYCHCSLNVNHNNNSEQQQWPCEKCDEIYYCSSNCRQLGWRQYHSFECGIYGLIAGPGDIFSFGNVYRYYAIFGHQLIDECKQNEYDKVCNDYIHNQRLRSLPLSEWSDKERFQACKLITLFLHHRNEHATLREAFAIFMSWVLIHLFVRKQILQANILDDLVEFSHRAEHLARDLLRMQTNAFCWSSGPIGFDLTNSSSSSSIIRLTTPNMIANCIQSIGSFFNHSCTPNVLWRFSSKGIHLHAKRLIKRGEQLTISYGTDATRQSIDKRQMQLHYNYCFYCQCMACRNECCFMKNVIQCLDDQCSGPLVLNKHNVCISCGQRPSNLYEAYGLMKKINAIRLQFFGLFDSLNNENVQNPISRIVYYIRYRSNRTSYLKPNQTEKKIKRLEQLYEKYRQIAYHGSYRLLYLSIIMVAIYERFRMPYKVFELIDTIDMNLMDIFPKYISKDNIILLIKSLESLCQLFEKLLPQIDFNGRFLPLSKNGAQDSDENGGFILRSKFVCLFERINQLLMTIFDEDISQNGWLFPKTFKRLHPDNDDDDTYRRLRLSEEEEYFKYLHQKCQQRIIHIQKWLNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7P8</accession>
    <name>A0A922I7P8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7P8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11638" checksum="9948CD07B3290211" modified="2023-02-22" version="1">MDCFYESPIAYDNLIHPAKINLSVTNENDTCFQHQHYYHIYTDGSKFENYVGAAFVVFSVHENRIPFLRKMFRLDNRCSIYQAELLAVVEAINWVVNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7Z0</accession>
    <name>A0A922I7Z0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gmc oxidoreductase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_005318</name>
        <name evidence="9" type="ORF">HUG17_3639</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7Z0"/>
    <dbReference type="OrthoDB" id="6480999at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276946" evidence="6">
        <location>
            <begin position="26"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="8">
        <location>
            <begin position="454"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7639606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9521684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="609" mass="68657" checksum="B40FC8022E65BE5B" modified="2023-02-22" version="1">MSTPSLTFQLLTVAIIVLQRQMIHNNVGSRTQWNTTYDYIIVGAGTCGSLIAGRLTENPSTTVLLIESGGPASVITDMPVEAWNIETGEFDWGYNTVPQANAAFAFRNRQMVFPRGRVVGGSHTINFNIYNRGNRHDFDYWANYYGLQEWSFENVLPYFQRTENNTNRRYVEAAPNYHSTRGQVEVSSPPNPDPILLKYMEGWNLQGLPYTDVNGPNQLGTTLIQQTITIQNHTRHSTSNAFIVPAIGRNNLHVLVRSHCTRILLRNNTNTNQLEAYGIEFVRNNQTYQVYANQEVILTAGVINTPQVLMLSGIGPRQHLTDLGIPVQVDLPVGQGLQDHLFTPVDYLTTDENLIQYGRDINNVLTVQNLYDYYVNNSGPITQVPIVMAFHSSKLNDVPDWPDGIMATLINRIPENVTTITGYFQDPDAWAEYFQPMAGDPRHFFVLYAFTLTRSRGSVRLQSRNPFDAPLIDPNYYGDLHDLAVVVDTMSAGMEMMEQPFFRQYARIYPRSIPGCQFCPDKPYYKCYTYLACHAQTLTLTAFHPTSSCRMGNSSDTGACVDEHLRVRGVNNLRVIDASIMPKIVNANTNAATMMIAERGVDFIQQDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I801</accession>
    <name>A0A922I801_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I801"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="257" mass="29723" checksum="484430C6D8E4209B" modified="2023-02-22" version="1">MYRIEADVEGTFFLNYHCQLQCNFTGRTRIQEVNSGQSCRPDSMEADRIDYRCQSGRCLPRQVPSHHQGPPTSPIVVPVPSRQIGHLTILSTKAELTTPELDTYLMICVLNNVAEPIHHLPLEDHYWLNRCHSCSSDLVRETRTPRYISPCPMSERYPINQNSRIIFEIWTHNSTQTLRTPNGKPGQFIGGAHLRLKELIDRRNLGRPYSMHISDEIINRNKNRNISYIFLCSLHSKLLLFTTRDPNDDIRLADNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I867</accession>
    <name>A0A922I867_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thimet oligopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_000821</name>
        <name evidence="9" type="ORF">HUG17_8555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7641086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I867"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF83">
        <property type="entry name" value="LD37516P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="306"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7641086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9526759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="799" mass="93198" checksum="B98D7691D7939BC2" modified="2023-02-22" version="1">MLLSKFIRFNSIHGRELHRCLTSKSKYDLFRRNNNNNEEEKKPTFLIFPEIPGETEETNEFLVLPTTGQIPFDGLNVEKCVLASGKLSLEFEHFIDEYSNTLKQEFEDGDVSNAKLNEFIGQMEKHLMPLQYNLNLLSAFKVIRPNEFDFRLFDHFFMQRLAKSRLRFQNRSIYCFMCEMKARAADYGKKEASSKCNHIHQEEVAKTNKLDEERKFQAQQKRQLVDRYIREAKLVGLSLKHQDQLNVYNLVNEKLNKEQQNFITAAMQANSVFQSNIISPQFLDCLPDHVITQLNHHDIDAVFNSFMRYCPDQTLRKDFWLAYNARAAPYLGSNLNNFLSIEKIRELRHQKAQLLGYENFAKMVLDLRGSGCHTMAGNVDNVLAFMNGLGSQSEAKFAKNLQEIKDFAMEFRPEGRRAQDAPSTFMPSNIMIEQLHLWDLKYFERLFLRERYQIDSGQVRAYFQLDRVVAGMFEFAERLFGIKIVEIKDDPNVWGRNVHHFKIFDDSGRSSGEYGSFYFDPFQPKSRIFMPIARSDSLNTKPVVFFLMDFAHRSGTVFDQLEKQKLQAAGKELLNFSQVVQLFGKFGFVLQHLLTQVDYSELGGLANIEVDTFNMVSHFMRLWPLNSYPVIAGCSSHFKTGEPISEEFFDRIRKSYYHFVSFPLKYELYLMALDLNLHTSHDHSTSLLRKTWSEWMMPFEAIEENGHTCSWLDLFKGDGQEGIYYSNKWSEVIAADLFDAFRERDLHNEPAIRQMGERFKDTFMAQTGAIETNELFRRFLGRDPTLNGYLAINGFVLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8B5</accession>
    <name>A0A922I8B5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004912</name>
        <name evidence="2" type="ORF">HUG17_7821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8B5"/>
    <dbReference type="OrthoDB" id="6498659at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7640354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9521238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="168" mass="19534" checksum="468CC9F29B81475E" modified="2023-02-22" version="1">MPTYDDRKKTVNYYGVFSLWASLLLLASYFSLFTSGCKQVATMEIQISLAVAFALGLIIFLLSFCNIASRLYHSKFSFYLIVIALLALATLLSYQAYQTWNHECKVGRYYERNNQLLFDNMTVKREEFEQTLQSIYKKRNNHYNVSALLDLIAAILFMASAYAFRNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8W7</accession>
    <name>A0A922I8W7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8W7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="79" mass="9547" checksum="4688BC8E273BE6F5" modified="2023-02-22" version="1">MNLRSHRRHQHEIKFRIGKNYTLLLNESPTDRKSKQFKHPSINGKEMITIFQPILNDQNQQRRQLDFDVMSYSNSQFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8Z7</accession>
    <name>A0A922I8Z7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-1-tetrahydrofolate synthase, cytoplasmic</fullName>
            <ecNumber evidence="7">1.5.1.5</ecNumber>
            <ecNumber evidence="6">3.5.4.9</ecNumber>
            <ecNumber evidence="5">6.3.4.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">MTHFD1_1</name>
        <name evidence="21" type="ORF">DERF_000640</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Derf</strain>
            <tissue evidence="21">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Derf</strain>
            <tissue evidence="21">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="7"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EC" id="6.3.4.3" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8Z7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001859">
        <property type="entry name" value="Formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1510.10">
        <property type="entry name" value="Domain 2, N(10)-formyltetrahydrofolate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="19">
        <location>
            <begin position="129"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="20">
        <location>
            <begin position="265"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAH9526565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1063" mass="117609" checksum="285418B04FD732FC" modified="2023-02-22" version="1">MQKNQFFLFHHDSNDYLNYHHQRSINWLSQSSSSSFHRKLPPLFMSLNHRTITSCSCCCCCCCFYGTIIGSLSEHHHYIRRTNIFSYFNHHSIIQQGLQQQKRKFSISILDRNSTSDNQNGNLKMAKLLSGKEVSDEIRARLREEVSHISIKPMLAIIQVGGREDSNVYIRMKKNYAESIGGNSIHLQMPRATNTQQLAAEVERLNNDPSVHGIIVQLPFDSEEPIDAHYITNLISPEKDVDGLTVINAGNLLHGKITGKEGFIPCTPFGCLELIKKSGVKMEGAQAVVLGRSKIVGSPMAQLLIWNNATVTVCHSRTKNLPEICRNAEILVVAIGKPLFVKREWIKPGAVVIDCGISSIPDATKKSGQRLVGDVDFDTAKEVASYITPVNKKQTSSLLINSLHRSSSSTKFQTLLSLVKMWKLEKSSLNRVTPVPSDIEITRAHKCKPIKQLCHEIGLHEHEYEPYGHYKAKIDRTIPAQFDQTKMGKYVIVAGMTPTPLGEGKSTTTIGLAQALCGHLDHNTIACIRQPSQGPTFGIKGGAAGGGYSQVIPMDEFNLHLTGDIHAISAANNLIAAAIDARYFHESTQKDSALYDRLVPKHPNKPRKFSKIQLRRLEKLGIPTEIDPDQLTEKQKLDFSRLDIDIDTINWNRVVDCNDRYLRSITIGQAPTEKGLSRKTQFDISVASELMAILALGNDMADIKRRIGRIVVAFSKHQPPKPITCDDLGVTGAVMVLLKDAIKPTVVQTLEGTPVFVHCGPFANIAHGNSSVVADKIALEMVGPDGFVLTESGFGADVGLEKLVDIKSRASGLRPDLVVLVCTIRALKSHGGGPLVTPGAILPKEYREENLDLVGKGLINLKIHIENIREHFGLPVVVAINRFSTDSDLELDLVRQKTIEYGAYDACIANHWEQGGEGAIDLARSVIDACFSNKNVENHFKFVYNDEDAIEMKIEKIATKIYRANGVEYSEQAQKRLELYKRLGYDRLNICIAKTPLSISHDPSLKGAPSGFKFPIKDIRASVGAGFLYPLAGEIQTMPGLPTRPAFYDIDIDTETGVIEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I920</accession>
    <name>A0A922I920_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ectonucleoside triphosphate diphosphohydrolase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ENTPD5</name>
        <name evidence="5" type="ORF">DERF_005266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I920"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24046">
        <property type="entry name" value="ASKHA_NBD_NTPDase5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF127">
        <property type="entry name" value="NTPASE, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="223"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9521628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="458" mass="53311" checksum="5514A69ACCDB970C" modified="2023-02-22" version="1">MNNMKLATTTTMMTFITKMMTKQLYILFILITALSITGPFISFNSKYYGTQLIRHPIESTKDMIKDQNFVIILDGGSTGTRIHIFAFEINFDIKQQRILLEREDFFHTTPGLSSFHHNLTELSKNLRPLIGKALDIVPGFLADRTPIILKATAGLRLLSNRDANRILQHVHQQFRSLPFKVDDDSVTMLEENDEGLFAWYTVNFLLHKLHKINESIATLDLGGGSTQITFSTYNMNTLIRSHQYIVQRNIEGEQEFIYTHSYLGLGLMSARRSILANDIDHSKSSSIKTEYNHHHEYWIRSPCFKILHNETYHWQQDQIVFHIQYNNDGDGQRTWFECLSRVEHFVIDANIDRPEELQHREIYAISYFYDRMKDIKVIRNDSGRVRVGDFFLYAENVCRGMIRIRQQNPFLCVDLTYIACYLHYGLGIPMTKDIMLVKKINGIEISWALGAAINLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I967</accession>
    <name>A0A922I967_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I967"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="8091" checksum="7A0ADCFC5005484D" modified="2023-02-22" version="1">MVEQEKQNDNDGAGGVPTEKKQIPNIRHMNMKYVNERFYFACLFVCLFGWTTISEFNDGDGDDNNFTTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I997</accession>
    <name>A0A922I997_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I997"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="135" mass="15913" checksum="EC2ED1F4BEFB5F62" modified="2023-02-22" version="1">MALILVNVVVDCSLNLLSEMLGGLGSLVFSKPHRRDQSLKYYKSVHRLNVYYLAIFCLGYFQVWLFSALAIFCFGYFQIWLFSVFGYFQYLAIFSLGYFHFGYFNPQSDIYLKMNNFKTIHSIFIKLKAFCFTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBG3</accession>
    <name>A0A922IBG3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Lysine-specific demethylase 6A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KDM6A</name>
        <name evidence="15" type="ORF">DERF_002385</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UTX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044666">
        <property type="term" value="C:MLL3/4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071558">
        <property type="term" value="F:histone H3K27me2/H3K27me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046941">
        <property type="entry name" value="KDM6_GATAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048562">
        <property type="entry name" value="KDM6A_B-like_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048560">
        <property type="entry name" value="KDM6A_B-like_GATAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21322">
        <property type="entry name" value="KDM6_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21326">
        <property type="entry name" value="KDM6_GATAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="460"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="14">
        <location>
            <begin position="925"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="67"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="544"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="611"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1252"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="580"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1252"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1271"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9528436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1282" mass="145676" checksum="A252CF99E8249346" modified="2023-02-22" version="1">MLTTMVEDVTKSLPPSTHHHHHHHFHQNHQHHNPTLQSSSISTATISFQQPQQQQQQQQQLNNISSINGSNVVDSNDAGMANISNNNNGQNQNSAPPPPQPSSSSSPSFQMLQLTTEEWNELNTIDSQLFGVFKPEDLSCQKLKSLLLKAIKCYDLALLNRNLNGSQTNSGGNGGANRLKSNAINPNVFCRLGHYNFLLGNRVKALSAYQRYLIADKNHWKNSAAIFGLGLTYFHYNAFNWTIKAFKQLIYTDRQFSRTNEAHVRLAIIYKFLHHYSLAHKHFRIALNDTNFCTLGKNELKFHIAHLYELEGKIKTARDQYLTILKQKDISPSLRADCLRQLGWICYSNDSLPLIIENNLQQPKQQSSQQQTRYYQAIKYLNESIELDNDPYTAYYYLGRCYACLNQVHDAFISYRHSVEKTEANSNTWCSIGILYQKQNQPFDALQAYICSVQLNKENITAWINLGLLYETYQQYNDAFKCYIHATKSTKEKSSLPIGVIERVKYLKSSQNNIMSISTQKLPSLELAWNNSVDNDMASKRHQSFAAAAAASSQSSTMDPNDPLMNNHNTAKRPKLENHHHTHVHHPHHHPSVVPYNHPQQQVSYDNMKNSFQSTTSMSSSIAQPNNTTKQQQSPTFFQNKSKRSYSVDSDVMSNQTISSDDSGIDSKDVYCHHSSQQQQQQPNKDKEDAIISLLSSSTASDSSQDPSIRQPKLSIEMNAQQIIDECKKFPSKTTRIISSITSDDGYPPFPPDPPYPPLPREKLNPPTPSIYVESKKEAFSPELQQFCLSNHIAVIRGLSSVLKLDLGLFSTKTLVESNSDHYIEVRRQYMQPSDENWDPEHRDMVWYCESQRSHTTIARYGHYQALSFSESLKEDKEKNSTTIFRDSDSDSNSTFSKNTKKHKKYSMFKPVKFGTNVDLSDPKKWKIQLQELAKLPPFARVSSAANMLTHVGHTILGMNSVQLYMKVPGCRTPGHQENNNFCSVNINIGPGDCEWFGVAPEYWGVIHHICERNNINYLHGSWWPLLDDLYAEHVPVYRFVQKPGDIVWVGAGTVHWVQAIGWCNNIAWNVGPFTSLQYDLAIKRYEWNKHENYKSIVPMINLSWNIARNVKISDKSVFTMMKSTLMRSLKYSIMLTNLIDDVGHEIILRQRDSQEPAHYCVVCDIEVFNILFVKEVDRKHVVHCFYCAQKMNPELNDFVILEEYKLDELTKVYDNFQLITTPAASTNLNTTNSSNNNHATTTTTTTTTATTMSINNTNNSSTTTMTPITVGGGGGGGGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICJ7</accession>
    <name>A0A922ICJ7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICJ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="98" mass="11811" checksum="A251AAACDDC221EA" modified="2023-02-22" version="1">MMLWLEKNSFRKNSFSWFFKSSLIGENSDDDDDDDGRGCLIWIEQQQRQQKFTTLTHSKSSSLSLSSTMIRFNQLFSDEYIHCYYYINSMITRIFFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICM7</accession>
    <name>A0A922ICM7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA- binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dve-1_1</name>
        <name evidence="6" type="ORF">DERF_001875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICM7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000169">
        <property type="entry name" value="DNA-binding protein SATB1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039673">
        <property type="entry name" value="SATB1/SATB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116:SF16">
        <property type="entry name" value="DEFECTIVE PROVENTRICULUS, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15116">
        <property type="entry name" value="DNA-BINDING PROTEIN SATB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="234"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="522"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="236"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="524"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9527886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="644" mass="71009" checksum="565F7BE1076EB6E4" modified="2023-02-22" version="1">MKPSLSFDLANNEITIGDLFGDICSFITLRIRLFRPRMSAAHELKDKLLQVLLAHSYNLLTTNNSGSSIDQQILSSLIRGRDQQQQQQQELNEDARRRFDQWYLQQVFNQYRQFALAAQQHSVSVSGLRSGNPSPGAASTAAANHPLFMDINNLANGNDTTLAAAAAAGLHPSLAAAAAAAATAGVRPSTVNGNIGGPSGNSCSSQDKPFGHSKNSSGNQNSQSGHHHSSGTSSRTRIRTSFDPELELPKLHKWFAENRHPSRIQVQEYVNELNSLESRKGRKPLDMNNVVYWFKNARAAHKRAELKFVSNDSNLSNHSFANALATEFFLNGGNHSPGKASSDASVSGKCNDEPMSNTSRNGSNLDDYYSFDEDNDSHEETQTLDLSIRNPLCMSTKLSDSPHQPLEDKMPDDGDDCDDFKFVDDLKRHDLNDISDLRLEPDVQLKIEPREYGGSAVSGNGSDCNSIDDESDDDTEATHNNNNCGHNNSMTSHSLASSFSALNHNNNSGNSSHNPESPEGRRTRRSRTFIDPMSEVPRLESWFMSNTHPAHSQIVRYTDELNKMPYRQKFPKLEPKNIQFWFKNRRAKFKRTSGMNTLTMNLSTNSAVVTSSAASNASGTSPSLSNASIHNSSALNIERLINAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICN0</accession>
    <name>A0A922ICN0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_000947</name>
        <name evidence="3" type="ORF">HUG17_4211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICN0"/>
    <dbReference type="OrthoDB" id="6513449at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7641167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9526889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37863" checksum="A292281FD0464F4E" modified="2023-02-22" version="1">MKSSSSPLQPISIHDSSLMIDCHISPPQCDGEQQQQQKSSKAISFGLKQTLIKMMIMLPSSSSSAAAAMFYGHLLTGLLLVVIVGYQSILVNCEHRAGSYRRNQQQQALYRAPCSQTTDCPFDNTQCNLVSKKCQCKPNFVQVDSFVNRSYITHLAMTCLHVAQLDERCISDIQCIVDYSECQLTVENVAGGINRTIHMCKCISGHELKHDQATVIIDGQPHRVRPICDPDNDRTNSSSWLITVVLISILVLVILIGTFVLIVRYQRLRQPYNQQTITSLTSQGGINSSHQMGQHHPLGSSSPPPMGSAEAEFQNDFIQVFPMHHLEPMPDKNVHAYIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICY7</accession>
    <name>A0A922ICY7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_002464</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICY7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9528523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="68279" checksum="FE3D76C02BE2C9BD" modified="2023-02-22" version="1">MANDDQNNDVLEREFERIVKDCVEKSKKQSNRSTLIASIFYLSVLFLIGLPIWYRTTTPERWPLPDISWLMVRSQTLTHYYKISIIHLNESDESFQNIDLRNYLHANHHTRISFDNSLSFRQEWTVRSAFNNELMAFKSIRNQDSFELNDLDQLLSADNIQSINSIMFYILPRNIHTDRFINAGRYRSYFIDLNHLDNICGQVDIVECLGEQINQYVHQVQMLITRFYSHQADKQEQNIVLLMARDFDFLFDIIYEDDHVDKNLNLNERKERHRKWIKQIDQLLERFYTHRFSFSQYFRINFITQVLHYVFPRDNFIQSKLLKSSNNASEQQQERLLPISSIDSILNRIETSRVEHDNDKSYHLVLYVRSQSLPVLKFFDNQTNNQSNLISTPFRGSILIVNDEKDLFNGFRQLIRSFLYLPNRCQVSGEFFTQLEIESIVHALVQKHIHETLKSLESIEKLLNKVSNMVIEEKISRRIHDSMEMSMKAAELLNSNGDIIEAYEKSWIAYSYSEQAFYDPSLLSLLYFPDDQKYAIYLPLFLPISIPLLHNVYHLFKMFKNRNMKIDDKDKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE32</accession>
    <name>A0A922IE32_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DnaJ sub C member 16-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dnajc16</name>
        <name evidence="5" type="ORF">DERF_003359</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE32"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052448">
        <property type="entry name" value="DnaJ_C16_autophagy_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036903783" evidence="3">
        <location>
            <begin position="22"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9529475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="813" mass="94794" checksum="C1C08112BBC7AB68" modified="2023-02-22" version="1">MNQFIWFTLTIIYCLLTICLALNPYRVLEVPKSATIAEIKKSFKNLAKKYHPDKNQNNDAQEKFIELNKAYEILMDPERKRLYDRTGQTEDSPNFKHKSDYRSGFNRFDFDTFDTFFDSNDGRNFRFTFNSGSYFRKHSITHRAYENTILPQSYTTPYILVFYGDLCVPCIQVEQVLRRLVGELEAVGVGFCTVHSQHEIALTRKIGVRSLPYIISLIDGDIRPFRESEISLSTMIGFIKRSLPKDLIIEINNNNYYEFLSGWKDNKVRVLFANPDRIIRLRYVLIAFYFHERIAFGHVKTDDANTNEVLRRYHIDPKMNSMLVFNEDINSPTASLSVSELKTQIMKDVLDSNKYLFLPRVTSQTVFDHLCPVASLPSRAKLCVMLVSGEKEDNKRKFHAMRAFMKENDFPKDRFRFMYIYREKQAELIKSLTNIGLSKKVNINRGIHVVILWRKESNQAFYEWLNNEWDFVDSTYINETKQKLNLLMTRLSQNAAQFTYSAKINSLTDESAKSLFARIVKRLLLVTENLSDNISRTDPTPILSVVFSIIFIIFIGYVMTYFITTQNVSICLLHRKIEEESIREKYRKMGRQVPGSSKPRSDCKLSIHELRGETYNGMIRLLKPGCRTIVLLCDNSSKSKLLPQFYKAVYPYRKNKTLMFAFLLVEKNIDWYKKLLLQTLGGERELNINPKNCIGTVISINGFRKYFCVFHAKHPENNIALRRMEENGEFLGLNEANENSGEESDVESGMLVRNHNPTNNNSNNVSDLSSINNENDDVIFENNLLNGLPNWLDKLFDGSTTRYYINFWPEHMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEW1</accession>
    <name>A0A922IEW1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEW1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="57" mass="6400" checksum="512633733CCB93D8" modified="2023-02-22" version="1">MTTKHCVRRELLLVQFLPLRPTTLLSFKCTTTAENILPAKLNAVSSYILLNIAISLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFR6</accession>
    <name>A0A922IFR6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFR6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9530042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="8646" checksum="23D014750CFED532" modified="2023-02-22" version="1">MLNSKTFVANFMPIRTIVIYRGGGSMFLYHSIPPGAFNDLRSRCVENLYFYTNNKHHYYHHDNYTIMSFEVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFT6</accession>
    <name>A0A922IFT6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="1">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SOD1_1</name>
        <name evidence="4" type="ORF">DERF_003325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFT6"/>
    <dbReference type="OrthoDB" id="6497185at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="3">
        <location>
            <begin position="91"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9529440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="231" mass="25042" checksum="E948182FCEA3FAD3" modified="2023-02-22" version="1">MALIRIFNKCFIHLAIYSIICCLIFMGIANQIQLPTFEDLDIKDLNIDTSLDYGPDDGGAEISQPVAAFTGADKDHGSMMIKAVTLIRGQVNGIVRLVQVGSGPTLVSGIVKGLYPFSKHGFHVHEYRVTGDCESAGEHYNPTRENHGSPFSVQSHVGDFGNLVADGLGFSRFHVTNPKLSLRGKYSVIERSLVIHQRPDDLGMGLNHESRKTGNSGGRLGCGTIKFVSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFU8</accession>
    <name>A0A922IFU8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine-rich hydrophobic domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CHIC2</name>
        <name evidence="6" type="ORF">DERF_001967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFU8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039735">
        <property type="entry name" value="CHIC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13005">
        <property type="entry name" value="CYSTEINE-RICH HYDROPHOBIC DOMAIN PROTEIN BRAIN X-LINKED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13005:SF4">
        <property type="entry name" value="CYSTEINE-RICH HYDROPHOBIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="5">
        <location>
            <begin position="307"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9527988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="428" mass="48460" checksum="77D4419697C630A5" modified="2023-02-22" version="1">MDRINFEQTSTDCRTNTQQKEEVNNNENENNEWKSKSELRTTRLSSSMLEKEKALDIHVSENHFLINHQQPSTSRIDHHIVDISSSSSSSPNAAPVNAMVAISLSSTPLKSHSTSLSKIVSICLDNHKDNNIDSQQVDSVVVCNSDNHAQQLQQPHYPCHQQQMIRTISNGQQPNNILEIERINLDDDDDDDGIDKINKRHGSSYRHQHKHQMNSSDTDDTDDDDAGVRDNIRRLNPVTSGDAGGITSLITTSGSRRQSQQSLSSNQNIDYLLSLLPPNELNMEMPFEDPIQIRGNGNITLFGLSNCYQSSFPSALLGRVSKEEFEYTIGRINHLLQQQHSTNIKFLLLGCLCCCFSLGCSLLWPGFALSRRTKNSLEKLLAMENSRLYNKLGLNWRLSKQPSHTNHSFMEYILIIDFLPKMHIYQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFZ2</accession>
    <name>A0A922IFZ2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFZ2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037756629" evidence="2">
        <location>
            <begin position="24"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="564" mass="60497" checksum="1C7D1546B02137BA" modified="2023-02-22" version="1">MSVSSMFRYIIVIIIATVAVINIDHLNPHHHHVSAVPVTNSNQQQQTKLQTSANEPTIKTTNSNVYGADNGGSTNQSGGGGTNGQQQQKPNSEQNPGSVNRGYNQGYSYNTGIKPYRTGYTYFQPFGDHVNNQNDGKNGNNNGNGGNVENNTNQQQLPIELPNFFGIDPKQLGPVRVIENKNLPLDENGIPILDQIHIPENTNENQNGNNNGNFNNRQARPLPPPPPPPQPPVPVPPVEVPVNANDFADFNLNNILSGNNNPNNNNNGYNNNNNNNNNNGGGGGMFDFAPPSTSNFNFARPGTAGADQSDDPSLMLDGNMDMGGSGNNNNNNNNQNGLAGFGFGGQQVPSEIVNLNNAFGTGGGRGGGASGTGNNNRNSGAGNLNDILDQFGTPNTVATNNNNNNDLGNLGSSTDMTIIIDHRCSLLILTLIVSLAIFGSFSIDETEFDVQPNFNLDPPKVAGMDGIMPENVGKPASLLLNHHQTQPSTAPQPQNEVRDISGWGMIGKIHPKILIKDQMIKAYHNRPLDPRYMHLQGYGQIQDPGHPTAVKNPTNNGMNKLFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KSU5</accession>
    <name>A0A922KSU5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_016728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000010">
        <property type="protein sequence ID" value="KAH9490530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KSU5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9490530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="255" mass="29751" checksum="0C8A8AB3CA90881D" modified="2023-02-22" version="1" fragment="single">NSLELSSKQFLATNYDSIIDTNNVNIEHVINVNEMKHGENDDELKDIRMPGVSDDDHHHTTTMLATKTKLNSNQHCHRITLISNNDTMYDDEIPDNIQPELNAKLNHRNCFAFSNTDGRNGLMDDDDSHVFADDDDDDDDYNSNAIYRICSSDVCKSNNRHRQQNCGLQRSSIEEYVDRTFNHNEHQSTNAFDNINDNDYDYDNGNGKNDLIHQYQLQRQKAMTINETFIQRHWNHFNSQQQQQQTTTTTTFYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KV24</accession>
    <name>A0A922KV24_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_014768</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KV24"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF496">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="884"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9494051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1077" mass="124662" checksum="26A5696166455382" modified="2023-02-22" version="1">MESKENYGSKNKLISPPPKYIRSTPYRFRESSPNRIRSPPKSPTKRRKTSPLSPRQQQQQQSPPQRIITPIKVKRPSDKYSYLDDICCIALICNEHQRIGLLDIPQKGLFFPSLSCRMSNYSVNSVVREMLNRIFGDVHAERIQIPVRNFLLRFIYRIDVSLSTTTNGNRSSNSGKNNKNVIGKRKTKVIDNQTNKMSSTSPNTTSGQQQKCICQMVQRTTIKWLSYDDICTKLSSTMTILESMNNTTGIGGGGGGSSSLLNIRTNTTTATTIINNNLLGPEPKYILEQQFGLLKKQVQKKQISSSSSSTPTPPNNDVECKNDNDDQMNSDEDDENDDDDDDDDDPSKYYSLGWNEVKLFNDDDDDDDDQKENDVHHEEKPPQPSLTNNYNQIDSMSSSSSSHQSNNEIFIKQKNNTIISGRREEIISLYNEFLLQCYPSRYMTIISFKLFMEKILSTPLTNERIVQYFRSFDRQQLSYLNFNNLLLGLLIVGRPFACCPSSQSSKECCCPCRQLKYRLLFHYYSSSSKILDLNDMNKMIIDYKRKTKNFLPPRYSGEKIINGNPNNNNNNSSSNDNNESMPQNRQQLEERFRSQSQIPMELTFKQFYHHIQNGQLFRLLFGLDNNMNVEEYFDKIIRINIEIDDLILPLWRPLTSTSQWIALQSSTQSTLRCYSCKRTRYYLSTYFHTLSEIGEVTEVNRLDIENISPSAINGVGVMTTTTTAANAQNVARQFRQDMQENEIHVLANDLINRLTKIGSFLFDSSNDNEIVNVDQLTLLENWFYKEKIEMINNLKMICQKAEEIFALEPRLLNISSPCYIMGDIHGNLKDLLLYSQLLWKSTPFINQGRYLFLGDYVDRGQYGVECIIYLFCMKILAPQNFLILRGNHEIRDIQQQFSFYGECCTRFELELWDSINRAMDRLPITAIIDGRLFCAHGGIPITITTLEQIRSVPKRIENPLYSSFETWEILWNDPVSGGELAKIVEFEKDNYERGFVQNTRRGTAFQYTEWAVDRFCQRNQIEYIIRAHEVYHEGFHFDHRGKTMTIFSSSNYSELTNRSAVVFIDRERIRIVQVKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVN8</accession>
    <name>A0A922KVN8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="7">6.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ACSL4_10</name>
        <name evidence="10" type="ORF">DERF_013665</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="7"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVN8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090433">
        <property type="term" value="F:palmitoyl-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="145"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9497701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="755" mass="85429" checksum="56D3197831F04C26" modified="2023-02-22" version="1">MIIEFLSDTFMIKTNMMDQWFNNLFLIIFDILVTIYTYITLPIYILRQKPENVLKKSQRIRAKQLNENDPKSPWFGVLDRQQYRGSVVDIVETIDELCNNLEKYMSLQNKAVGYRRVLREYVVYGSDGITPLKIDGKIIKKRELSDYNWLSYEQLFERKNHIAKGLLSAGIKRNEPIAILCETCAEYLMMEFAIARAGFVQVNVFPTLGESGIAHAIKETNSKFIFTSWDLLPKIRSVIQKYKLDVSKIIYIERRAETVSDEIIAKEKDFIEPINQSIFVPLTKIEQDGQSCNDDDVAICKPLDKDQVAFIVFTSGSTGVPKGVQLTSNQMIQVCHQMLPSLSEYIGNGLKNIYVAYLPQAHIFESTCEFLIFGLGIPIGFASPFTLTESSPGLAPNTKSDLVLLRPTFMISVPLVLQRIQKQIYNKLESRSSIFIPLFNYLMKYKIIWTQKGFATPLINRIFCKKIREQFGGRLDKIIVGGAPLSSTLQSVIKAALDTTLVQGYGMTETCGACFCMDNDDLTYGCTGAPMLGVYAKLDDWNEGGYRTSDLPNPRGELLVGSKANCLGYLNKPDATDELLVKDEKLNINWVRSGDIAEVYPDGTFKIVDRKKDLVKMANGEYVSLGKIETTLKNCNYIDHICVFGNALANYLVALVVPNEEKLVHLAQTHRIPNEARSTNRMSEILLKSVRETGIENGLKKVEIPTKIQIVSDEWTPDNEMLTAAMKLKRSSIKTRYFSVIDDLFNDSQSNSTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KW40</accession>
    <name>A0A922KW40_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox protein prophet of Pit-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PROP1</name>
        <name evidence="10" type="ORF">DERF_013886</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KW40"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000138">
        <property type="entry name" value="Homeobox protein prophet of Pit-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="257"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="259"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9497956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="514" mass="55036" checksum="EC70048F31117568" modified="2023-02-22" version="1">MSQTTEKQQRQNSTTKSTSSTSSSSASSTPSSSSSSSTPICGNLNVNSLTTTTSDDNINNDFTTTLYGMAALNGGGGGGGSNSNNTQLMDNNNNNNSGTSSSSSSSSSSSTTTSGGHHNQNHHHHNHRLLNDNNNHHHHHHSVFTFPNVLSNSTETAFKKLKVDNNTNSHHNHHHHSHHNHQHHHHHQQSTLVPPSALPPPPPPPPPPVLSHLSVSSGGGGGLSGHSSLMAGLTSVPTSLTSAISTTTTTNSCPPTPARRRHRTTFTQEQLQELETAFAKSHYPDIYCREELARITKLNEARIQVWFQNRRAKYRKQEKQIQKALTNSSMLPACNGAMMRNIYHQAQAVQAQNRNHHHHHHQYHQYSGGGGGGVGGVGIGGTVASNSTLNTMAAAASRYHAPIAAAAAAAAAATSAYHTHSMNGPNGTSPFSGMTSTTAAAAAAAAVSMNHRQQQQQQQQQQQQQTDIDNENDWYNKGFNALRMNNGNSHNQHNHQSNLSSAVAAASPMLQYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KW66</accession>
    <name>A0A922KW66_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Glutamate receptor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">DERF_013930</name>
        <name evidence="24" type="ORF">HUG17_0755</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Derf</strain>
            <tissue evidence="25">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">JKM2019</strain>
            <tissue evidence="24">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="24" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">Derf</strain>
            <tissue evidence="25">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KW66"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008328">
        <property type="term" value="C:ionotropic glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004970">
        <property type="term" value="F:glutamate-gated receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06382">
        <property type="entry name" value="PBP1_iGluR_Kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000064">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000001">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10 24" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324749" description="Glutamate receptor 1" evidence="21">
        <location>
            <begin position="28"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="560"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="858"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="22">
        <location>
            <begin position="468"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="23">
        <location>
            <begin position="478"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="558"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="724"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="725"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="773"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="18">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="18">
        <location>
            <position position="703"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="18">
        <location>
            <position position="730"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="18">
        <location>
            <position position="819"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="785"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAH7645217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAH9498001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="976" mass="111590" checksum="91164A064CDB8F7E" modified="2023-02-22" version="1">MNKVRSICPSIFRLLLLQLIIIGYQRQHNHVYGLLPNVVKIGGLFENGDELVEMAFRDAVARINSDETLLPQTRIEPIIERLEPCDSFQASKRVCSLLRQGVATIFGPQSVETTAHVQSTCDVLHMPHMETTQWNFKFDDPPFHHSVNLFPHPIGLGNAFRDLITLKNWKSFAILYEENEALVRMQEILKDPALNEKRIVVRQFPSDEYRTTFKELHKLAIRNIIVDVPHEHILTVLKHAQQVDMLSAYHNYFFISLDVHTVDLEEFQYSGLNISGFSLVDLTSKEVTEIVHKFQQQHLQDGILDDVTANTRYHWNSLDTNMINIGQQQQQQTIDNTIYRMVSSNNFTTEIALVYDAVRLFAQTLYEIDKNGQHFQQPEDISCENEKVWKFGTVMSNYMRNIQMDGITGPIKFDSTGSRSEFKLQLLELTREGLKHVGDWQPQEKITFMSNYTKAMTEIYRESLRNKTLTIVTIGGEPYCMEVDDAENRTGNDRFEGYSVDLIKEIADLLEFKYTIKLVEDGVYGKRNERGEWNGMIRELIEGKADMAIADLTITYEREAAVDFTMPFMSLGIGILYKRQKKEPPTLFSFMSPLAMDVWVYLMTSFLGVTLFLFFVARFSPYEWVNPHPCNKDPIELKNNFSMKNTLWFTIGCLMQQGCDIMPRSLSTRVLAASWWFFILILVSSYTANLAAFLTVERMVNPIESAEDLSKQTKIPYGCLKSGSTEAFFRSSNFSTYARMWSFMESYRPSVFVESNKKGVDRVEKGNYAFLMESTTIEYIVERKCDLFQVGSLLDSKGYGIATPPDSPYRSIVSDAILKLQEEGKLLMLKNRWWSGKGKCGGQKETQKVSVSASELGLANVGGVFVVLAAGSIIAIIICIGEFIWKMGNIPRSEREHIGIELLREIKYVICCYGNTRPIRKVYDWDPTRSLIIEPTLTGGAHNIGGIGDTGIAHPGQRQYSFPVDDEKNEYLFGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KWB6</accession>
    <name>A0A922KWB6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KWB6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9498076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="81" mass="8651" checksum="A4198BE6BFEBE614" modified="2023-02-22" version="1">MATLVEFSFVTYIGSLYLLIATVELVELAELSTRLLTTFSGRRDNGPIRCLNIGICVIAVVGRIGYDNGAVAIGENATRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KWN1</accession>
    <name>A0A922KWN1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guided entry of tail-anchored proteins factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tail-anchored protein insertion receptor WRB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Tryptophan-rich basic protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_014339</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KWN1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9493600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="105" mass="11888" checksum="E5D3656500134934" modified="2023-02-22" version="1">MDAVTMANASQTIIKSNIDDDNEPNLSLFYLVTSASLFSAFIPVIVSLLLNLLTWDSQMEQSLKRQVSDLKEELGSINMTDEFAKYSKIQRKLIKITDELKNKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYM4</accession>
    <name>A0A922KYM4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_014116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYM4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36489">
        <property type="entry name" value="PROTEIN-COUPLED RECEPTOR GPR1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037159693" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="31"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="443"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9493364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="555" mass="66821" checksum="4528F42454402336" modified="2023-02-22" version="1">MLKFFLFLFISSIVIVSSANAEDAAIDYRQFIKCPEHPDSSRYLRNPYDCSSFYRCYVENGTRLAIWNCPNDQYFDEDPNVQTCIRINDYLAKYHECKTIPLPTARPPTQRPTERPTEKPTEKPTQRPTERPTEKPTQRPTERPTEKPTEKPTQRPTERPTEKPTEKPTQRPTEKPTQRPTEKPTQRPTHKPTQRPTQKPTQRPTQKPTQRPTQKPTQRPTQKPTQRPTQKPTKRPTQKPTQRPTQKPTKRPTQKPTQRPTQRPTQKPTRRPTKRPTQKPTQRPTQKPTRRPTKRPTQRPTQRPTQKPTTKRPHHHDYHDYFDIWRRIMDNIIHDYFHNHHDYHQHEKNHHQHDHNKHEKHHHQHDDDNDYHKHENHHHHHEYHEHDNHHQKHHHNDHHEKNPMLSLITSKVEEEESMIQLQENFYKIIAQQQMNSTVDYRKLIHCPSNPSGRRLRNPYDCNRFYLCYKQGDQVRLALYNCPHGTFFDDTPTVQNCILRSDYEERYGQCKTLPLPHDDDDNNSLAEIMKKIVKKIKDYLDRKYREYEEHHHHHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYU1</accession>
    <name>A0A922KYU1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYU1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="141" mass="16178" checksum="00CAE7477463914C" modified="2023-02-22" version="1">MLIPPLNKPYIFSTKDFCFGSILDRDQIVITNISRKILDRDNLPVTIVVFSTAFGRSSIITKIFGLRLGRNIGYDCGFHVLDVAKLLRIFELRHRDQICGYENIEIDRGNCIAKFWKFGFGIASPALNFGILKSWITITFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYX5</accession>
    <name>A0A922KYX5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Epsin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EPN2</name>
        <name evidence="9" type="ORF">DERF_012795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYX5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16990">
        <property type="entry name" value="ENTH_Epsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000002">
        <property type="entry name" value="epsin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF115">
        <property type="entry name" value="FI19443P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9501992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="572" mass="62656" checksum="50DC7829981DA856" modified="2023-02-22" version="1">MANMLNVQELRRNVINVVKNYSDAQVKVRKATSNEPWGPSATLMAEIADLTYNVVAFSEIMQIIWKRLNDHGKNWRHVYKALVLLEYLIKTGSEKVAQQCRDNLFAIQTLKDFQYMEETKDQGQSIREKSKLLVNLLKDEDKLKVERSRALKAKERFSQSMSYMGERSDNGEQAFRASTSYPESLSHNETSSRALNSELESARPQTAGEEKLQLELALAMSKEEAEQEERLRKNDDLRLKLALEESEKNRLKSGDVGETSHQSAVDELLSLAGPSTSSRVNDPWSSTSTPATAPISQSSTSAGSLLPSPPINSKSHRVVTNHQQNDPWSTVQPTGSNSMDFDNLKSNSLAFDDPWSTTSSSQAPVIASNDPWSLNTTAIGPNVARNDPWNSPSSSATLDKKSFDGLPEPVKTSTTTPIRRTPESFLGPNSNLVNLDALVSSSKLQSSTSPNNNPFASAVPQPVMNPFQANKPSQPTINELRAQTQGSGMLIGSAPILISSSPSSSVNTTVPFSSSSFHQTSNNFTTLPLYPQLPQLSSSLHSSSQQNSVWGNSNNGQSSAFTLSSPNNPFAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L093</accession>
    <name>A0A922L093_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cadherin-23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CDH23</name>
        <name evidence="18" type="ORF">DERF_012505</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048589">
        <property type="term" value="P:developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000306">
        <property type="entry name" value="Cadherin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000168">
        <property type="entry name" value="Cadherin-related family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000033">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000039">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000123">
        <property type="entry name" value="Protocadherin beta 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1863"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="101"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="208"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="323"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="447"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="598"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="716"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="832"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="953"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1073"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1179"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1293"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1405"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1513"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="17">
        <location>
            <begin position="1642"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1907"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2083"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2128"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1908"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2097"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2128"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="2149"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2164"/>
            <end position="2178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9501676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2207" mass="246035" checksum="2EB2BA8ADDF453EE" modified="2023-02-22" version="1">MFSSPVSRRFEREKDNRELELRRRKCCETIDFRSSLFKSNHHHHHHHHHNYKNVNKSSLYIIIIIVEIVLIQLTLISINEVWATRTNLPPRFKSDSNDFDTQSEIVVRVKEGASSLNKEIYHLYGEDPDNDPLTFGVLGTLGKDLLRIESISNNEAKVYLKKELDREIQDSYTLVLTITDGKLGKGNYITKSLLLIVEDINDNAPIFRPFRTAVLVKENAKPGTLIETFEAFDSDEGRFGQVFYQLGDEIHDTNSLGSNMFSIQTVDGKGILRLSGQLDYERKSLYQIRVLAIDRAMEDSRKTSTAAIVIQVEDVDDQPPIFTSIPSVTRISEDTPIGGHVLQVTAIDGDKGVNNPITYRIIKGGNGLFSINSNTGIVSVAGKLDREASVTDSGTEAIYSSANLLSASYILEIEATEVTHAIFPPPSVTTEVTIILTDVNDEVPRFRFKSYTAEIIENSPSDMPVTFTRRNAKNNRMDTNDQAMNSLLSPQVYDLDQGNNGTFTLHLELDDDQSLDKDLRAQLVDTFYVTPLQSTNDATLSVRIRNSAALDYEKLKQIKLRMIAKERSPSAGHQNLRFTSAELIVSIKDANDNAPQFSQEIYYGSVSEIPKPGTIVAQVSATDIDDGLFGTDGIRYTSLRGDIAAALSLNPMTGIITVKNDTDNKDSRNSVYFDREQHTQHFLIVEARDAAGFGNKNTVQLVINITDVNDQVPRFLQSSYTGRIYENQKRFEQDLFVSALDDDAPNTANSRILYSIVNNSSPFSPHFNIDPNSGKITVAKPLDFESIPGQIADSRNISFKVRVHDHGIPPLSNQVPVNILVFDQNDNAPVFSKSLYTKSIPEDVRDGSMVVQVSATDADQSPANSRVYYRLLSGGADKFVIDSNTGIISVAKGASLDPDKSLSIGSSKMSKKLWYLLKVMAIDSSFGTEEQLSSIATVNVSIIDVNNKAPEFPNNLPEVYVAEDAKINQFVTQISAFDLDDKPVLRYSFDYSRSEARNDFGVAMDLASFAESFSIGPIDGVVRVAKSLDRELWSILKLQVVVEDIAAITKGQKARTTFTIHITDINDNPPRFIQRLYRAIVPENSIPGTSVITVTAEDRDTNKSLTYSLESEEFDLLRLLRINSTTGEISVLGRIDREIYNWLNLTVRAIDHGDPPLSGTAEIAIQVLDENDNNPVFDDENLHKVTIPEDSPIGSLVVRITASDADIGAFGKLTYLLDSSSSLGKFKIDRETGSIIVADHLDREQIPFYKLLVQAWDNYEYGFSTGESRKAFKTLTIVLSDVNDETPKIVFPSPESECTFISEFHSQNDPVVTIQAHDADDPSLPNGQISFAIVNGNDGHLFEFSPSDTANSVVLRTRSSLRGRVGNFTIFIQVSDGGLPSRISTSPIKICVTDVNDHNPIFVKPPSNMTIRIPENATIGTRVVDVLALDSDHGLNAEVRYRLREIANGQWRSFQIDPITGVITLSKELDRESVRVHELRVQAYDLGTPTPLSTDLDITVLVTNVDDFEPEFTQDVFQVVFTENLSPGSERYKLLPTIDKDDYDFSDPNTAFKSIPCYFIVGGDGLSKDNEELFKLDTFTHEMSTTKPLDREQKSNYTLIVQATNDCFRVPHRVERFDPKDNSMLQVLVGIKDVNDNPPKFLKKIFSGGITTDTEYGTIFMSVKAIDPDVGTHSHVNYYIVSDVRKSFSEGLENVPSKPFEINQRTGEISLKFDPQKGMKGYFEFEIKANDTDGLYDIAKVFIYLLRGDQRVRFVLRLTPQELREKLDKFQDVLANITGALVNVDSYRFHEAEDGSVDQKKTDLYLHFVNRDDNSIMDVDNVLMLIDKNIDYLDDLYKEFNVLISEPTSMAEPFMEWEDQLKAGLAGTSAFLFLLLILVISLCLNQKSRYERQLKAATVPIFGHEPQLTRSNVPNTNQHATEGSNPMWMTGYDNQWYKDEERLSSESSSSSSSSNSLDENALTNVAIEDEHLNFSSLDTLDQGDVTHEHIAVRSESSGNSSSSTTNDRSVLCRISNTLSKPTSAIASNNRTMNGTANFGTVGRRHQMITTTQLSNPPAPLKKPPAPKPPAPNIVVISATASSSTINKNDPRNGHYVSSSNGSTTNNGKSPCINNIYIETFSNHHKNSNGNAISVNNGGNKHIPQSSTHGHYHHYHHHHSHPHPHQQSSTTTSTQPHHYFGMNKGQDLSNDHAYLPESQLMNLETTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2D5</accession>
    <name>A0A922L2D5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1443"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1327"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1462" mass="166936" checksum="004C7D479E3C1290" modified="2023-02-22" version="1">MSIVLAETTNSGANFKTTTATTVIQDKIQAWPFSPSYSSLSLSSFSPLNITTKKPFNITSTKTIMNKTKPLVMLKDKNIINSTKLPSRIQQNSLFPVPYMTLKTNNKNNETTTDPLIDRLFRNGRETHDAFIRRIILAAAAKAKANLEQQKLPNQIFYGSKDQNSQQTMAIKQALKLPSRPSTSPNHPHRIQYKQSNKTTTISTTTTTTQTPKISTNRDNFPLISKPMIFNPIRHVLLSSTTPMHTTTVPTATKTTILLPLLFTKPMMMKNQKWTPSSILQHPNKTLFQVIVNVGDKPIVLTGATPMTTPPTTSVTTPTTKIMMTATTSIIPTIEHTTVATTMKFINPGIHMMFKQTAENRKNSTLNRFKQKQKDELASLLKKELDAKKAQLNQTKSSFSDTFNLVSNGGDLLYRPLDHYDDKISNNKQHDDNQHIITVSDSSIQEEDQLDEWITNLTHLKPILAPPYHLPFRPLLISKHNNKIDKIKNQAIIIGHPPYEKPSHYNRNHNRHNSHYYYHHNNGQNSNGTVKPTTLWTPKISTTLIRNTEKMNQNSKKFTPTRHPSIMTTKIKDDFSYSNPNRFISLRRSTTTTTTTTRKPSILSSRPGVKIRIKNYTTTTTTKTKTSTTERPNFTPIIKYKNHTINNIRPNPTKFYNNRTMNNKFKQNSIIAPKTTTTTTTTEETITFGANDAIIIDDDNNREFMPNTTTTTTTMSNNIDSDVNIFFDLNSDESRLSNTSIGWNNRSTNVFYNNDYDHDDNKNSLQKQSTKLNKLATNNKNISIATTEMPILTSTKMNIGITTTTTTTTTTTTTTTTSTNGSSYRLTTERLAYILIGSCCALSVICLIIVAMSVRFKDMCDEYRHWKHAEKAALRWQQQQRLRMTASHHPHSHQHHQLQPSMGSTREMTSWFPLHPADYTDGPIGYLSKSQNNPLLNNSNKTTRFNLPRYFRTNISNQQQSLNHHDHHHHHQQQPQQLQSSTKLPRTTMTSLPLNGHHRVNSTDRLLDTIFSGTKLSDIEPITNNTIGNNGLNRNQCCHCMNCSQTWFFRNDRHGDWCCQRGYYQPPKRNRLPFGAASSVNTFMRQLRNDPLDSLIDASVETTKNIQQNHHHHHHHHNHQQQQQQQQQQSNNQQSTTRHCFSHFDHLASQTSGHNNNNNNNNHHHHLMMNNDSKSGLGSSSMAIVCSNTNDNNNRNNGNNNDHNDGIRRKKFQNHRNFSTDNMATNNHESTSATNIQQHTNHSHNNNNSNKLLNSNGSNKHLSGGLFFYAQTNNQDNRNDNVDIIIDDDGDVDDVVIMGNDVDILIPTDNNNDCIDVDFESNFGAHNNHHHHHHHHHQQQQQQQQQQKRSYKQQHHHRQQQQQQQNHVQSTAAAIRKCFQPLSTKSQSNSTTTTSIVADNKCKILDAVNNHFNGLNNQNCNQLNHYHHQRNNEISSAKIALPKAAKHQQQQQQLHQRNRNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L349</accession>
    <name>A0A922L349_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_007429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L349"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16500">
        <property type="entry name" value="RING-HC_CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000110">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF34 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051728">
        <property type="entry name" value="RING-FYVE_E3_ubiquitin-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055111">
        <property type="entry name" value="RNF34_RFFL_HeH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057299">
        <property type="entry name" value="RNF34_RFFL_SAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879">
        <property type="entry name" value="CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14879:SF15">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RIFIFYLIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22968">
        <property type="entry name" value="RNF34L-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23632">
        <property type="entry name" value="SAP_RNF34_RFFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9516703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="433" mass="48542" checksum="C47596A66DE67FB1" modified="2023-02-22" version="1">MFSYATGTSSSSSSSANNRNNNNNNSSSRENCRNSTNQNNSSNPRGQSFKFNFNESFRKIYDDFQDIKVSFDDISKNIPEMNKIFNISKTSCNSCNSVNSNIFARKRKCGKCSLTFCSQCMVYNPVPSRKSICNRCTVFSQHPISKEALNSLKVRDLKWFLASKNISSHHCYEKSELIDLIISFRNGTSSSSSSGINSSTNAHQRRHSYANASASSNNDQQHESNSSSSSNNHRQNFYETSSHSSPTSFYNNLNNRSPSSTSFESHNETVDLNANSNDNDTINSNSDKTNKQANKTSPSSSSSSSSMNIKLDDIKNEEEIRKLSVKQLKLLLTRNFVNFKGCVEREELVGKVLLLYNDKKQNDILKDQLETEKASINSGGVDENQCKICWENVIDCVLLDCGHMLTCTDCGKVLSECPICRQFITRVVHVFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3D7</accession>
    <name>A0A922L3D7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MAM domain-containing glycosylphosphatidylinositol anchor protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MDGA2</name>
        <name evidence="4" type="ORF">DERF_011745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3D7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037577355" evidence="2">
        <location>
            <begin position="34"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="3">
        <location>
            <begin position="187"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9507041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="822" mass="93494" checksum="2F48038233BFD087" modified="2023-02-22" version="1">MVNLLKMKFLYHSNVMKLLYFSSSLLLIGFCECQSGPFSNCPSLRNALKNGYVKLRSYPNRVARFTCNKGYDLIGNRYSTCSPTYCPNKLNVPPPLIVRLISNHSSVVDLQCEIGYRIQVTKKTSGRYFSDFDHNSYQASSIRAYCVSKQWLIDDWNQPDHSYTSSMIPLDQWPTCEIYEKPIEKSMNCTFENRYGSICGWMQDNDDDFDWTRNSFTTPSFLDGTGPSFDHTFGVNSSGNYLYLESSYPRAPNDVARLYSPVFQHVENSSIACFQFYYHMYGKAIGTLRVFVKEKYQRFSDLEPVWEMSGDQGDQWLAGQVEIQPISPTFALQPFQIIIEGILGNGHQGDIAIDDLLLTLGKSCSMITTNSTTVDVVSEPSIADILDSTDSPINSVNSSSSILPKPSKWHDSHFTELDDDDMEMDTSHLNDPILPHNEIFRSIVHLKPITTPLTTTTTTTTTTTTTTTIATTTKATTPSTTTKTTTIKPKISTIIATQTESKSTTSTPTTTTATTATSSHISTTLKNITESSTRLSTTTGLNAALQAKAIIDITDITNDKKHFAAHWSVIMIVFIALIIPTQEQLQNDSESVTLYRVCDRQFRQKLYLKCYMERKHVCPHNHFSIYGPILCNSTENCSTLHSHHRETIETSPTAILLKYCIRMYLPLPYYDIHFDQKFMVTCRVIMSIESSTNNNNNNDQQQQQHRNPKRTIPEQYIDHQFTAKGHGEILREARNMAAKLVINKLTVADFIVTITRIIPTQDQLQNDSESVTLYRVFDRQFRQKLYLKCCMERKHSNVYKNNSDDIIKTDNRKFGRPKCSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3N1</accession>
    <name>A0A922L3N1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3N1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="108" mass="12879" checksum="E25B9A3A041720D3" modified="2023-02-22" version="1">MEFGLIYENMVNEKNNHGNDAEHYKFIGGYLVTNMVQCPMKHYIRHQNMPALNCRNSSKIHGMEHILENDHGSQANNWEIESRTTDRIWTLSWNMDRDYGFIYVKRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3R1</accession>
    <name>A0A922L3R1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3R1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="181" mass="19838" checksum="3CDFEEBF0285DA7F" modified="2023-02-22" version="1">MANGSHNHHHHHPDDVLMATNNRTSSSSILYDFISTTTTTATTTTIGKNFTQHLLLPSSTSTATAVSIIDQQPFDTESTSTIIAINNDNNNNLIDENQLINHMLTSLKMAIENNCTDLDQTSLSSLLYHLNMTTTSTTSSATSMNNNDILAEWLRNETIGLTNTSSSSSSSSSHHHHRNYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L491</accession>
    <name>A0A922L491_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L491"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="481" mass="55709" checksum="6FF4F2D5EE49FA7D" modified="2023-02-22" version="1">MAVNINVISPQQPSGLNRTAFVGNTTKSMVFNVKLPDQFIYDNDDDYGGTSLQSLSIGNRLPSLSTTTVATTIDEQNDDDNVNPDKFIKSILQGPSKEFVNDSHDKKTDVSVTIFHHQAIHDKNKNDNQTNKSINLYGNGYGLHYGYDLDGQYSREKGYKFEKALGREICKDKKSCKSTSERRYDDDETLADYTPDTALKEHIRQIIRHGNDIDLNGLLLKKKQRKKILIYDDDNNNKKNSQNYFNGPFTKLDSLHINSSPTQTMVMKKSKFQPQHVSFYYPEMIETNRTSPIINHKNYGLILDSMNENRPYKSSDIITLFKWTNPTLSNVYYPHKILHLSDDDYQGKSGYMKHWQTSSSPSPKSIGKIFRKHHGLEYDDLQRDLSQVKSHRIKMKNSPISNNKIHSHWFIKPNLGPNESDQQPQQQQQPQQQQQLQQYHHWNQIQDLSTSNNYQNSILESNLNPYSKKFIKFLSKKLYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L608</accession>
    <name>A0A922L608_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L608"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="98" mass="11712" checksum="F6B2B55B75F11EE6" modified="2023-02-22" version="1">MIEMIKCVEINLLTLFVLKKKIHPTPDKTVLLKEMKLYFFYRFCLFLSTLWHEGRRNGLLPSPLPSMANRQLLCCLLCDNHRMLDHEIIKLIYCLKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6B9</accession>
    <name>A0A922L6B9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6B9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7355" checksum="3EE77A73CBFD1E5A" modified="2023-02-22" version="1">MIINEFHSPMMTYIVQQQKKTGCCANRFGHLEINTQLFSDLSLKLLSAILRDQFHNCRGGGGGGGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6R7</accession>
    <name>A0A922L6R7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6R7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="108" mass="12072" checksum="38BE96222BD85E96" modified="2023-02-22" version="1">MIFFLKLSQDDNEVPEEQCNKDLKDDDVDIDDNSSNVSKEPCLSVASILSPINLLPDVGNDSFSFNFDAGSLSPTSESIFLQLQMILVGNLYQELQLELMKNKLSKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L769</accession>
    <name>A0A922L769_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Prefoldin subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PFDN5</name>
        <name evidence="4" type="ORF">DERF_008657</name>
        <name evidence="3" type="ORF">HUG17_2706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L769"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7638673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9518054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="181" mass="20727" checksum="2E4EF0C83D5C78A1" modified="2023-02-22" version="1">MASTKNQQPKKIELNINDMNLYQINAIKQQLDQEIEILEKSIVDLHNAKTKFVGCFETVESFEKLPNDNQIMVPLTPSLYVPGRTVNNNEFLLDIGTGYYIERDRKSSIDYFNRKVQFLNTQMDKIVKSMQEKGTVRQSCLQRQQQLVMAQMAAQQQQQQQSSSSSSSATNQSKQGQIVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L785</accession>
    <name>A0A922L785_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L785"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9518099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="88" mass="9945" checksum="5CCF780B64B1AAF9" modified="2023-02-22" version="1">MTDQKNGSLNSDPMAVVVSGCHVFKSRLCQKFGLISSVKKSRFKFPTKKKRCPNALLIIMCSTVGKVIFQVLGDRFMKSETKKKCNYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7R5</accession>
    <name>A0A922L7R5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7R5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="200" mass="22827" checksum="EE8DCD0FF1347209" modified="2023-02-22" version="1">MLVATSGSFSASNTKDDVDLDQSSNYEQQQIIIRHPNLTNGGGSNETTDDHDDDGKKTTKQQSNKKNLSLRQSSKSNHYDQNDDDDDDNDDDEDTDMVVDDENENDQRHDHHNIVDDDDEYEIDVDVDTEPDIDISTESEFHIHGSNGSIRQPLDCIPVETVLREHSSSSSILNDGPPLPPPHQQHYYHRFINHQQHHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8A4</accession>
    <name>A0A922L8A4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NDUFV1</name>
        <name evidence="17" type="ORF">DERF_000068</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29092"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. Interacts with RAB5IF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8A4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="370"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9525938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="476" mass="52514" checksum="C86297863118CB3F" modified="2023-02-22" version="1">MKSILQHHRTLTASQVKLFQIRFQQTSASDSPPPKTKFGPLADEDRIFTNLYGRHDWRLKGALKRGDWYKTKEILLKGHEWIQGEVKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIMRHDPHKLVEGCLVAGRAMGACAAYIYIRGEFYNEASNLQIAIQEAYQAGLLGKNACGSGYDFDVFVHRGAGAYVCGEETALIESIEGKQGKPRLKPPFPADIGLFGCPTTVNNVETIAVAPTICRRGGKWFASFGRQRNSGTKLFNISGHVNNPCTVEEEMSIPMKELIERHCGGIIGGWDNLLGVIPGGSSTPILPKDICSTVLMDFDSLVENKSGLGTAALIVMNRQTDVIKAIARLASFYKHESCGQCTPCREGTGWMNKIMWRLVEGKADPKEIDMLFEMSKQIEGHTICALADGAAWPVQGLIRHFRPVIMERIQQYQAKAGNNDKEKIKAASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8T5</accession>
    <name>A0A922L8T5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RPL13</name>
        <name evidence="10" type="ORF">DERF_000883</name>
        <name evidence="9" type="ORF">HUG17_4156</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the LSU, it is probably required for its formation and the maturation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the 60S large ribosomal subunit (LSU).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8T5"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7641112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9526824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="214" mass="24870" checksum="0114B72EF75936C1" modified="2023-02-22" version="1">MVGKRNGMIPNAHFHKDWQRFVKCWFNQPMRKKRRHQARVAKARLVAPRPTERLAPLVHCPTIKYNSKVRLGRGFTIDELKSAGIPRRFAPTIGIKVDYRRKNRSVESIQRNVARLKEYRSRLILFPKNSKKLRAGESSAEEIKLARQVTGTIFPIVKSKKSLKSEKARVPTESEKKFHAYHSLRRARANKRLIGVREKKEKEAAESLDAPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8X1</accession>
    <name>A0A922L8X1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Golgi transport 1B</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Vesicle transport protein got1b-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GOLT1B</name>
        <name evidence="9" type="ORF">DERF_005660</name>
        <name evidence="8" type="ORF">HUG17_3383</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8X1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7639350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9522057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="138" mass="15299" checksum="DA70F592C80F5C33" modified="2023-02-22" version="1">MLSDTQKIGLGLSGFGIAFLMLGTLMLFDKGLLAVGNLLFISGLAFIIGLERTFWFFFQRHKWKASTSFFSGIIIVLFGWPIIGMILESYGFLLLFRGFIPATIAFLSRVPVVGFILNMPIIRTIVNALSSQTGRNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L901</accession>
    <name>A0A922L901_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GMP reductase</fullName>
            <shortName evidence="8">GMPR</shortName>
            <ecNumber evidence="8">1.7.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanosine 5'-monophosphate oxidoreductase</fullName>
            <shortName evidence="8">Guanosine monophosphate reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_001053</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8 11">Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8 11">
            <text>IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:17185"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.7" evidence="8"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L901"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902560">
        <property type="term" value="C:GMP reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003920">
        <property type="term" value="F:GMP reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006163">
        <property type="term" value="P:purine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000012">
        <property type="entry name" value="GMP reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00596">
        <property type="entry name" value="GMP_reduct_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050139">
        <property type="entry name" value="GMP_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005993">
        <property type="entry name" value="GMPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01305">
        <property type="entry name" value="GMP_reduct_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003470">
        <property type="entry name" value="PRK05096.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43170:SF5">
        <property type="entry name" value="GMP REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000235">
        <property type="entry name" value="GMP_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="1 8" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8 9">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="8">
        <location>
            <begin position="286"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="287"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="315"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000235-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9527004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="350" mass="38245" checksum="CAB09BD103D2DC08" modified="2023-02-22" version="1">MPTIEEGIKLDFKDVLLRPKRSILKSRADVDLNRDFQFRNSEHKYHGIPVIAANMDTIGTFEMAIVLDKHNCFTCIHKHYSLEEWRDFAQNHKDTLKNVAVSSGSSQNDFEKLKEIINIAPDIKYICLDVANGYSESFVTFVKDVRAAFPHHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVLECADAAHGLGGHIISDGGCTCPGDICKAFGAGADFVMLGGMLAGHDQCNGDVVVKSDGQKVKQFYGMSSGTAMNKYHGGVAEYRASEGKTVEVPYKGDVEKTILDILGGLRSACTYTGASRLRELPIRTTFIRVTQQTNEIFRQLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L936</accession>
    <name>A0A922L936_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L936"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="593" mass="70051" checksum="A23E7455B72FCCCD" modified="2023-02-22" version="1">MSYCAVYLNRIHREKNLPEKPEDPLILEKSIPYDAEFTFIDFVPSVLTYSSSAHHQVEYHRFSHLIDTANNWLDKNSHWNIINCETVRLSYRHNVTSMVSRWEQQINPVTPLWSPISRGEFETSLKAFRLWIRRKDKFDSDYYNNNNDDIMFNDKFRKLKHLDFIPKRLNENSFETIDQLLERVNGRLKQPDTLFWNIITLESLKIEANSEWFIDPEISLADESSRHLTILRLFYEQYKSGDDMNAIILEENDDYPYTVIGIEDFKPELLSAGSFFKRPEFEPFCSLTQRASRWLNSQYVDYFLNAQSIDIKIKSPSKLETRNCTNIEHGHYIQFLRIVYCKLLPRINNNDSETIIKRPKSTHEQQQQQQQQTTNQSSSSSSDNNIIQLCSKVFVATKLDHPLDSMQQRIYNWLHHQDNNQQQNVCILGAETINVYGKDDDEKVLEKKTSDCFYGNRLGSLNTFTFKAIRLYYCQIPIIGDNDHDDNDFIDKDSRAKYYRCTGKTFQRKKSRNFTYSNSNSNNNNREKSLQRKNSKLKIIRSNSFRMNNVTTKQSSMNEKLDEKESNRIGFIKSLRRSKSHIQNHHSTSCNCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA41</accession>
    <name>A0A922LA41_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA41"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="525" mass="57413" checksum="27A764D449E1034B" modified="2023-02-22" version="1">MDINGDNDDDDDDVDLCDQTEHEKVCLVGGTTNNIQDQCHQMSIHYPICSNEEPLLSTTTSNTNKQLMTTTTIAASNNNNNNPQNSLMASEIIMQSNNVHHSFNHNCDIGHLQITTQQSQQQQQQQPSSIVSIDSHYNHHQQPSPQKGVGGSVTNTIIGNNRTPYDSSLSRGTKGPLNHRTSIITPAASSTGLSSSSTSSSPNPISTTKPIPISATAAAIGIIGQPPPPPLPPLPHHQIIYTHSSPSNRSPNHHHLNSPYDIDGSATVAIAAAQYSQYHPYMNTAQYISPHHHHQQPHYVDTNNISCLYTTSSSSANSPSYHHQMYETGESALYVDSFEAAPSGQFMTDLMAATHHHPQQQQHHHHHAHQQPILYYNPSDEITVHDTMVNNNCSNNNNNSPNNKKTISKRSNVTLLQSATTPTSTPSSTITDLPSIDGTNNSSLYVTTHSQTGTKLTKNNSTMVMENLSNCDQQQQQQQLYHLRQSSVSSSQSNSNNNNNNNSGQTQSSSHEKICLINKRNGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAE9</accession>
    <name>A0A922LAE9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAE9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037725684" evidence="1">
        <location>
            <begin position="22"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8434" checksum="890F05E59AE944DC" modified="2023-02-22" version="1">MQHLAMKACQLDNFLLLCVHTSTITTTTTTTTTTAKRRKKEENQNQKFRLVCNDEYEKLVDYNAVEYTEMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAV0</accession>
    <name>A0A922LAV0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alpha-aminoadipic semialdehyde synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_002787</name>
        <name evidence="10" type="ORF">HUG17_4898</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAV0"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12189">
        <property type="entry name" value="LKR_SDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000087">
        <property type="entry name" value="alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="9">
        <location>
            <begin position="34"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="8">
        <location>
            <begin position="204"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7641853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9528879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="938" mass="104515" checksum="E30EE946E7865E15" modified="2023-02-22" version="1">MYIPYLTARSTAVAIRSISHRFKSTSVDGKKILAIRREDASIWERRAPLAPLHVRQLVRKGVKVIVQPSNRRAYPLQAYVQSGAVVQEDISEAPVIIGVKQVPVDLLLPNKTYAFFSHTIKAQEANMPLLDACLDRNIRLIDYEKMVDSMNQRVVAFGRYAGIAGMINIMHGLGLRLLALGHHSPFMHIGPAHNYRDSGSAKQAVRASGYEIALAMMPRSIGPLTFVFTGSGNVSQGAQEIFQELPFEYVDVKDLPHVSQLGQTTKVYGAVVSRADHWVHKNGSTFDPEEAEQHPERYYSNFASNIAPHASVIVNGIYWAPDSPRLLTIPDAKRLLQPHYAPWLPTSIGSPALPHRLLAICDISADPGGSVEFMTDCTTIDNPFCLYDADYNQKTSDFAGPGVLVCSIDNMPTQLPLEATQSFGDLLKPYIFDIINSDANEPFEKFKGSDVVQRAVIASNRELTSNFQYIMEMRAHKDKSKLGKSRADNEKSVLVLGAGFVAAPLVEILTRDEKVHVIIASDLQTPSENIAKNAKKSNAESVVVDVLKNQDLLETLIKESDLVISLLPYSLHPIIAQKCIQFEKNMVTASYKTPEMKALHDAALEAGVTILNEVGLDPGIDHLFAMECFEQVHSNGGKITSFKSFCGGIPAPESADNSLLYKFSWNPRGVILNTLSGARWLEKGKLYEVPEGGALMDAVRDIDFLKGFSFEGYPNRDSLIYQDVYGLNSVHTLLRGTLRYKGFCNLMKGFHMMQLLNTNPHPLLHPNGPDITWRQFIANLLAQPEDILPTTVKNIMFDKIGQDEQRMQAFEELGLLDDEMIAKKHSPFETLMYYLTNKLMYQPCERDLVVLRHEINVEWPDQSKEKRNIDLVVYGDPDGYSAMAKTVGYPTGIAANMILNGEIQEKGVVGPTSVNVYNTMIKRLRMEGIRAIEKSTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBC3</accession>
    <name>A0A922LBC3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRAPPC3</name>
        <name evidence="10" type="ORF">DERF_003261</name>
        <name evidence="9" type="ORF">HUG17_5261</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBC3"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7642216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9529374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="180" mass="20576" checksum="5F65412E3A95D06C" modified="2023-02-22" version="1">MSRQINKNTIETKKVNSDLFVLTYGATIAQLVKECENAEEINKQLDKMGYNIGLRLIEDFLAKTQMAKCHDFKDVADKIQTAFRIYLGFAPTITNWSTANDEFSIIIDNNPLTEYVELPDHLGNLRYCNMLCGVIRGALEMIQIEAQVYFLQDSLRGDPVTELRVKFLKKMEDALPNSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCB0</accession>
    <name>A0A922LCB0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCB0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="371" mass="43923" checksum="FB9C6E6638BE039B" modified="2023-02-22" version="1">MVNKNLSDHQPSETSLEMAVIPRRTDYSRRNNALSVEYDLFSFNKKTNQNDRIIFSLLGALVLILFLFIIHLFILKPLIISTNSISDRFTDDSWIHMDQIIRKNVGYIRHKNANTSDDDDNLILMSTDLKWLNHLQLNSANVSFCYKQDDLSLFYHYCVDESQYPIIYDQDCWPHSIDLYQQLLMTRNQTNLAKLNTSVIDEFVQIYHRFLNNSDGLKSIKNEQLSLAFSYAKKIGRDCEHSELWQQNFNLSLPSGRNEKEMWELYCLRHIRYPNIVSINTGKYYVPEYYLQLIESDSNGKRSLASDEKWMHRWMVEKFIPLYRSNLVLQKRFENESKNSIIFAKKNVKIFIKPSFSLVSDLNVIRFFNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCD5</accession>
    <name>A0A922LCD5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCD5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="5983" checksum="0AB519FC81115974" modified="2023-02-22" version="1">MASGIIPLDSSRKRELRNAAAAGKPAANMAAAAAALAVDVGLMAANDGAPQLANMACCNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCW4</accession>
    <name>A0A922LCW4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_004120</name>
        <name evidence="11" type="ORF">HUG17_9378</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCW4"/>
    <dbReference type="OrthoDB" id="6484726at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:sphingolipid biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="150"/>
            <end position="171"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="232"/>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="ARBA" id="ARBA00022516"/>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022832"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KAH7638272.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9530307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="321" mass="38268" checksum="49874DDF63E8BD26" modified="2023-02-22" version="1">MATTIVKNTYSLFGFELPDYRYTYYNVINESHSWDPDVTKFPGFQNSFAFERSFIPIGNWIQLQTQLYWRYCFHLSIAYVIIIFGIQRIMRDRQSFNLRTLLMFWNLVLATFSIIGTYRCLPEFIHIIRTEGLRASYTKSSYYADFRLSIWYLFFTISKAFELIDTLFIVLRKSKLIPLHWIHHIMTLNFSWFVFTDVPATARWMVNMNFVVHSLMYTYYALKALRFHIPKPVNLTITTLQVAQMFAGLYINYDCFRRKLMGYPVDTCYSVLFTGVILYTVFAILFMNFFIRTYVLPAKPINQMLSDINHNHYKGVVKKCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HK79</accession>
    <name>A0A922HK79_DERFA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_016709</name>
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    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HK79"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9490511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="54" mass="6469" checksum="C4051E410A4CEB0D" modified="2023-02-22" version="1">MDDIKIRKSQKNLPSSKSEFETGQLNDHYEDDELRNRKYIPSSNINNQNEWIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HL50</accession>
    <name>A0A922HL50_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cuticle protein 57a-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_013046</name>
        <name evidence="4" type="ORF">HUG17_6287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HL50"/>
    <dbReference type="OrthoDB" id="6515429at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062129">
        <property type="term" value="C:chitin-based extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008010">
        <property type="term" value="F:structural constituent of chitin-based larval cuticle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031311">
        <property type="entry name" value="CHIT_BIND_RR_consensus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050468">
        <property type="entry name" value="Cuticle_Struct_Prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000618">
        <property type="entry name" value="Insect_cuticle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10380">
        <property type="entry name" value="CUTICLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00379">
        <property type="entry name" value="Chitin_bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00947">
        <property type="entry name" value="CUTICLE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00233">
        <property type="entry name" value="CHIT_BIND_RR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51155">
        <property type="entry name" value="CHIT_BIND_RR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0193">Cuticle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276896" evidence="3">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7643925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9497032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="109" mass="12116" checksum="0CBF30ACE256144F" modified="2023-02-22" version="1">MFKEIITLTLCCLFIAVYAAPATTTAEKEEPPHPYNFAYEEKDANFTITRQEEMDEHGTVKGSYSYIDRDGVFRTVNYIADENGFRAAVQSNEPGLTNSAPAAATIQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HM26</accession>
    <name>A0A922HM26_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HM26"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="107" mass="12746" checksum="C0AC8877F4069995" modified="2023-02-22" version="1">MIKARAKISFACLVYNYNDQKVVNNNQCNTVFNRNDDDLHGQQIYITFSYLGEKERKMTRGLQLFFRKKNTQTDFNASAKYIDQQYNHQQRTNESFPLFTFNKGQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HM29</accession>
    <name>A0A922HM29_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HM29"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7755" checksum="599242D0CB5ECD25" modified="2023-02-22" version="1">MDDNSFVFLSFSGMFLQQQQHPHDNNNNRYKSYLKTYLLKTSSTHLINIIIMIEVIGEFRESVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMY1</accession>
    <name>A0A922HMY1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin-related protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ACTR3B</name>
        <name evidence="10" type="ORF">DERF_013784</name>
        <name evidence="9" type="ORF">HUG17_0892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMY1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7645354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9497829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="418" mass="47853" checksum="1169D56D980CA159" modified="2023-02-22" version="1">MAYSMPAIVIDNGTGYTKMGYSGNREPNFIIPSAIAIKETSKLGDQASRRLARGVDDLDFYIGDEALDATGYSVKYPIRHGIVEDWDLMERYWEQCIFRYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFETFNVPGLYIAVQAVLALAASWTNRQLYERTLTGIVIDSGDGVTHCIPVAEGYIIGSCIKHIPIAGRNITYFIQNLLREREFGIPAEQSLETAKAIKERFCYVCPDIAKEFEKYDKNQSKWIKKYTGITAITKQPFEVDVGFERFLGPEVFFNPEIANPDFVTSLSDIVDTCIQNCPIDVRRPLYKNIVLSGGSTMFKDFDRRLQRDIHRLVNQRMKLSYQLSQGRLNPKPIEVQVVSHNMQRYAVWFGGSMLASTEEFYSVCHTKSQYEEYGPSICRHNPVFGTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNZ9</accession>
    <name>A0A922HNZ9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNZ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="348" mass="41689" checksum="745AFB8045A65C79" modified="2023-02-22" version="1">MWFYFFCSVLNYRSSLDNLLCNKKRSYSERRLSKYNRQYLCHYFTISNRIFMSLIHSISCTIIISIFVATYLSFNYYLNDDISFSKFILFIPIYLIGSSHTNFLVKLFIGIGNYLLFYTKFLELRFLQLKRMMNIIVRGRNVEMKTSKLRLPSHYWYHFQIGYVRCYEELKKFNQTTRTLFLFGEIINKSATIFVCSFYSKQQQMNMFNSSCVFVSILIFILMNIVYYRLATLPGYNHYCCHRLILPWLARIQTFNVRRSRTRFWLKTNFFLQTMTANHFGFTCGQFFIITKFKHIELILLNLPWIIKLFGQNAAIKLIFMSIFCPLSYSLMGSQFFSTISTSDLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPD9</accession>
    <name>A0A922HPD9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPD9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="198" mass="22740" checksum="A6A8607388EE1DFC" modified="2023-02-22" version="1">MAITFHKIEYNIIRTMTTLLIITLIILSVYHLNLTLEFLKKLIDHIEETDSVYERHASKNRTLAKMMFEPMQRTAHSMYEKHEPAILMNVVILTSVIAFSMAGLVAALRKHKIMLFIYAIALDLIYLTTFLYCARLPSLHCSLIVFVSIIVYLRVHHLWSKNSTDKVHLLQASTTTSTTTTSAADINHHDLMIKNNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPG8</accession>
    <name>A0A922HPG8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013413</name>
        <name evidence="1" type="ORF">HUG17_6015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPG8"/>
    <dbReference type="OrthoDB" id="10341236at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7643653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="243" mass="28239" checksum="25F21492C57A3264" modified="2023-02-22" version="1">MATFFGEVNDISSRSAWWSDSDCDDETVPDDDVQKTSKLGKFSINYENGFTPDSEFKFERIYVTNVKSIPKNLKTILTISIENVKVPVCYLNLLNNNDHPQCCWLAINHRILSQHEYLTVQLVDYLFDAILKKLIDSSKPELLIISKQKNRSSYVQYLRSPNTNDDDYIVNLGKKCNIKKLMAPETSNDEFELATMQHCIIHRINFIFFILPTEYDNGQFVPKTIRDSLNQFYDFSHNNNLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRK2</accession>
    <name>A0A922HRK2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FIP-RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_011098</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRK2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037245">
        <property type="entry name" value="FIP-RBD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019018">
        <property type="entry name" value="Rab-bd_FIP-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057316">
        <property type="entry name" value="Rab11-FIP3/4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051977">
        <property type="entry name" value="Rab11-interacting_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726:SF7">
        <property type="entry name" value="NUCLEAR FALLOUT, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15726">
        <property type="entry name" value="RAB11-FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25450">
        <property type="entry name" value="Rab11-FIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09457">
        <property type="entry name" value="RBD-FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144270">
        <property type="entry name" value="Eferin C-derminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51511">
        <property type="entry name" value="FIP_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FIP-RBD" evidence="10">
        <location>
            <begin position="365"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="114"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9506361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="459" mass="52772" checksum="E309C7380C3F88D8" modified="2023-02-22" version="1">MSFIDDKTLSEYFNVGDNDDSIDDDDCDEFITNHHNNNNNNNNSISTNGNSGGGNSSSLKFIQRNSLLNSSFRKSTPMKNKNSLHSNNSSMNGINNSRGSLSYDSDNQLMINDNNSMEEYIIHLTDKLKKLQDQVQFLREGQQKNEEKYSTMKRENSTLNNKINYLEEQIRDIELQSEDKRKEVEQRFRDSMARLEREKAQELENCVSRICSLQKESIEAKEEIKRHQQTIERLQDVREKLEIEIHDKSDEIQSLKNEIRKLKEIIRLKNEERDAIDSSLIEAINHELSIERNHHNLFVNNNNNNNNHDHHNNHHSINHDIDNEMYSSIHSELEQQLRILKDENKTLKENNEELTAQLLNNHLIEGKSLLKEGEAISSLASEISDLNLEQLKTALKEQQDVNAKLRAYIDGILLNIVENYPQLLEVKSNGGGGVGGTTTTVAAKHQSPSTNNGNRSKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS80</accession>
    <name>A0A922HS80_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinase</fullName>
            <ecNumber evidence="6">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_013933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="6"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS80"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.160:FF:000001">
        <property type="entry name" value="Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF97">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9498004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="643" mass="72700" checksum="ECB6643DFDB6F1EC" modified="2023-02-22" version="1">MALLCLPLSSSTTSSLPSLLANVVMNSRINRDNNNNSQNQNDDEDGDNLNKQDRFETNEPISRSVPLSLSNQIYSMFTSSTTLSSSSLIIPTTKTTATSIIHQQQQQQSYDDQLRRASWPVTILNNQQQQKQIKIFKQKSSFQNDDSIHLPNNLSTSSSHHEHEHESGQRKLSCCSGSSSTTSGYMSTSSPTHLHHHHHQPEFQSDSSSPSTIISTTKTISTDLQPIMPLSPPTPQSRLQQQQPPPPPPSVVISDHSSMDHIHIHSIIQFDSDSGENDYESSDNNNRRDSLCSIYSSTSSLSSMGDDDDDDDDDSVFQSSTQIETSSSLDETTTAKVTKKSSKWRKVRSLVTSPFIQTYKRKKYPWIQLAGHQGNFVAGQIQGTIMKKLCGNEIDCFEKLMSDTQLSVLVPEFKNIRIVNGDTYLELEDLLATFVNPSVMDIKMGIRTYLEEELVKANEKPRLRKDMYEKMVAIDPDEPSDEEKLQKAITKPRYMVWRETISSTSTLGFRIDGMKSGCNCLKTTSPSVKDFKRMKSVDAVRSAILEFVGDKHEYLITYLEKLKLIRKQLEQSNFFQTHEMIGSSLLFVHDQQHANIWMIDFAKTYPLSDGLQINHRDQWKLGNHEDGYLFGLDNLIQIFSSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSH1</accession>
    <name>A0A922HSH1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyco_18 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Cht11_2</name>
        <name evidence="6" type="ORF">DERF_011164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSH1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF390">
        <property type="entry name" value="CHITINASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="819"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="762"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9506431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1217" mass="138096" checksum="13A3417AFFCB5AE0" modified="2023-02-22" version="1">MVLGLLTGSMPMLVSLLFMQGITLTMWRSFLDKAIPNLNNDKLRRGFQQMMPTTVQSANSLQSIPQSPSSTDQFSTPSTSSSSMIMDQSSNNGNSITNSLQLLANLDPRIVQLLAQVSGGGGQTQPSQQQSNSITQTTAPSPLSSPIDQMNILNSLATLLRSSAPSSMSMPQSNQQIPLSLLLQNSQPMQQQYQYLQQQQQQYTPIIDPNNPNIKYYEVSSSNPPGQIDGQIIQYEQQQPYDIDGENLKYDHIESHDDDTKTMKKSSSKQPSTIQDDEPEEEYDDHDDEEMDEKRKNSDLYEEVDYVDDGNEAEETTGDDEPEEDYDELENESDTAKSSIRDRISPKRMFTATKNKIQMFRHHHRISKRMIRLDLSPLQTKLKEKFKNAFPFLRRNSNPVHNDRKPGINKKKIESKKIHYKNNNNNNGRKLSTSSSTQNRQQKPLPYQQSWRRTTDQHKDNFRFATPKIPILPDDDNDDDDDDDKQDIVKKEEKPRKNIKKSTTKKKQFTAEKNSISSDIDEFEANFCNVTLNKIKTNKKFGEIWSKKNGWSRCHPKSPSFRISKGIVIPAINIESPVDLSTTTTSPDDDIDESTTTLPVNEEKEGDDDNDVADLELTTTEISELETTTATTTTTTTLESNEMTTEQDIDDETTISTTVATTQLTFPINSDFFINFNNFLATLGSSSTTTTMSPIFFSASPPSTTTTTTTAMAPTQTWNHVDEIPKEFLWHILKVINASKIDNYQVNPVVVDNLKNHNLNKPKSIIDKKHENVENHRNNDNDDDDDDDGDEEEIDEELFHQIKDDNNRIDGKILVAHRFKRVCYLLLNGGKDGGNIEINQLELHICSHLIVGYARIATNGLVVAQKPLEDGERYRLATMMKIQYPKLKVMLSIGDLGGTMFSIVTSTNRTRERFIISILDICTEFNFDGIDIDWEFPGFRTPGLSRDKQNLVQFLKELRQMSKLIWPNDINNNNNRGSSSSFLISLAVGAPLMIASTSYLIPEIEKFVDFVNLMSYDFHYYRPDKPYTGHHAPLYPRSTDNAYFSTLNVAWTATYWANSGMPLRKIMIGVPTYARTYNLVVPIVQNMINLPASGPGIGKGKLNYTRVCEFLRLPGTVKQFDFHSQVPYAYNGFDWVSYENELSVATKAQWVVKTGMGGIVTFALNFDDTKGICRDDGKRFPLQKTISNVLELAAIKSYKKSLHVPFQFRNHDNNNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSV7</accession>
    <name>A0A922HSV7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ARPC1A</name>
        <name evidence="11" type="ORF">DERF_013990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSV7"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="10">
        <location>
            <begin position="108"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9498068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="386" mass="43444" checksum="5E92C554D1A85C27" modified="2023-02-22" version="1">MMSNSEIHTFGVQPITSHAFNSNKDKLAVSPNNNEVHIYHKEGGGKWNLNSSLGQHDLRVTSIDWAKRTNRIVTCSADRNGYVWTLVDGVWKPTLVLLRINRAATCVRWSPKEDKLAVGCGAKLISVCYFEEQNDWWVSKHIKKSIKSTVTSIDWHPNNALLACGSTDFRTRVFTAYVRDVDNSINADEVKATWNGKTDIGTMLAEFHSSQGGGGWVHCVAFSPDGTRLAWVSHDSSVSVVDSRKSMHPINVRTTFLPFLSCVWCSDNLLVTAGHDCCPMLYCYDDYSGEIRFLAKIDKSTKREADGFSAMRKFRDMDKRALVENTVSNTMLDTVHQNTILEVRLYSDFDSKLRKTEQISTIGVDGKMVIWDLKSIESSLANMKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSZ1</accession>
    <name>A0A922HSZ1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MPC2_2</name>
        <name evidence="11" type="ORF">DERF_012827</name>
        <name evidence="10" type="ORF">HUG17_8608</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSZ1"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7637504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9502026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="126" mass="14390" checksum="A1144BDAFC8032B0" modified="2023-02-22" version="1">MASASSMIYRTMIRSVDRYVPKKLRPLWEHEAGPKTVFFWAPAIKWGLVIAGLSDLARPVENLSTGQTISLAATGLIWSRYSLVIIPKNWSLFSVNFFVALTQVTQMGRIIVYHNQQRKQQQKIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HT06</accession>
    <name>A0A922HT06_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HT06"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8814" checksum="B6311F5B477B730F" modified="2023-02-22" version="1">MRTPNQQQQQQQRQQNTITRPNNHNLKLDNSILSIDGNLPGRLLTYPNRIPKKNCHNMSWSLLNLIYEFKNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTP0</accession>
    <name>A0A922HTP0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein SPT2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SPTY2D1</name>
        <name evidence="5" type="ORF">DERF_011735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTP0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF8">
        <property type="entry name" value="PROTEIN SPT2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9507031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="607" mass="71271" checksum="A24D2C5182841169" modified="2023-02-22" version="1">MDYQDLLEAAQRNTEQQSSLLRRRQMNGLNRGPDPMAIANLRHEEKQRLLSLRAQNSKSMRKAQMMKSRTKDNNFGRIVTTDDDRLIEEKIRQKSIDDTKKTRKDRDKVMKRLEQEEPVKVQPKTMKISDIIRQSSKQKTNGPNVTNNQTKLKTSKQQPPPLSYDQLLNMAAEKSTQKISLEDEIKSELEFQEKNSEKKRQALCAKEKQRQIDYYRNDAAERRPMAKTKTTTTTQEVKTQNSNCKQSTNDKYHHVVNRTPASKQMKTTIDQRSKKTDQENPKKLLDHNRNSNHHHHHQQQQQFRQQQQQQPQSKLSQNSTKHSSSVGAMTNMNGNRLQSIRSENDGKKRMASSSSSLTASSSMKNRDNQSKPSKPRLQQQQQRQQQQQPIRTLSPANMFDTKSSMSSKQTTSLSKSLPQKSVISKTTSLSSSSMMDNRNRLQQYQPQQRQPIHQQQRMPPPQQPRPKLPPIGATYRRGIYYDYQQDDQYKNDVDDDYYNNDDYEDDEMDEEDDEMADFIDDGPIEEPEPEEEYSRHIREIFGYDKRKYRNIIEDDIEEASYGQCMKEEMRSLREGIREDLEDIRREEQEKRLKALQKKARMKGLKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUR6</accession>
    <name>A0A922HUR6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUR6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="7109" checksum="5406480D151ACB19" modified="2023-02-22" version="1">MIFFLAPVACWNNFQPRKLVQKKNKKKMIRLDHPYIIIITTSAYTIHDDCEGIFKLIADGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUT9</accession>
    <name>A0A922HUT9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_009370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUT9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038104507" evidence="3">
        <location>
            <begin position="31"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9510869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="250" mass="29488" checksum="E11C5F87FEFB2D63" modified="2023-02-22" version="1">MAIVKKLLRRLCSPFLNKLLLLILVEDSLRVLLVGTLNLTGENEESTFDDDIDVVDKLKSIGVGIDLSLANLTFINCDFFPYNPNGSSCLELSERDNFCFEIKNFKFDLFYFKHVIELEQMSNISHFSCSFDLKLFIKGKHDKDNSQTILIFLTTFVFLMFLAYLMALVIGSHIARMQVRYYIIRIINQQRQQQQQQQQQQQKRSRHHHQQEKNQQQNSLELFLTKLDEEDRSRKCRRFSFSCSLTPQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV80</accession>
    <name>A0A922HV80_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable nuclear hormone receptor HR3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear receptor subfamily 1 group F member 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_011561</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Putative receptor whose ligand is not yet known.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV80"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="NR_DBD_ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nuclear orphan receptor ROR-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044101">
        <property type="entry name" value="NR_DBD_ROR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF2">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="14">
        <location>
            <begin position="110"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="15">
        <location>
            <begin position="670"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="207"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="263"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="353"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="499"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="353"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="499"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9506849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="926" mass="99535" checksum="0AE3D1B5F4731079" modified="2023-02-22" version="1">MHLLQLLTPPDSYILPDTSSPGLHTTMSSWTTGFTTKVEIAQPQPSSGSIKVLDREIRQQNDCFSHHHNDEDDKNVDYRSLSTQQTTTTTTFDPDSTHSLMIPIKTQIEIIPCKVCGDKSSGVHYGVITCEGCKGFFRRSQSSVVNYQCPRQKNCIVDRVNRNRCQYCRLQKCLALGMSRDAVKFGRMSKKQREKVEDEVRFHRAQLVRPGSGGGGGHSQHPSSQQSTINKNQQQQPPPTMIQTGGGNGQSICGMTQIVTASTTTSPNGGQVLTGLNGSSNNNNNNGPLITNIGQQQQQQPPPPSITALHGQLNNVSAATATNGNGGCSTQQTNTSVVVAAVASSTQFVQRQQQQQLKQETSPDSSVLEQQPPQQPSSSSQHVSYSSSTSSASLTNGYSTYPNGDLSGTGNIGHNSPGTTTTTTTTLYHAQDNKPYTLYAAYTTSGGGGGGSNGTQHSTSQQQQQQAANNNNIFDIIPSSTDFVDSTTTQFGELKPITATATTQNNNNNNNCQTTTTTNDPTATSSSSAAATTTMSPDTNCGGGSSLHPLNSTITTTMIGSPINDCSGGGGGGGGGGSSTTTIQQNQNNCLVTLTANHSHLGSFIDHYPSFNAVFGPINSAATTTANNNSAAAANVSGNSSIVAAGSTIIDGGGGGGGGYNFSIQHPHNPLELLTKTVADAHSRTCLLTTEQIIDCKRKPMDLSRVFEFKNLSHDQQWLRCADKLTDMIQQIIEFAKMIPGFMKLSQDDQIVLLKAGSFELCCLRMSRYYDLNTKQVVFNGGLMPIDAFLSQADITESKLISQAFQFAEHLADLKMTEAELALFSAYVLISPDRPGLKGILEIQRLNQAIMKALRNELNRTHKNTFFIKGDVTIIDIIIAKSGQLRELSILHMDALNKFRRQSSHLIFPALHKELFSIDQPDQQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVS1</accession>
    <name>A0A922HVS1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_011818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVS1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF18">
        <property type="entry name" value="IPT_TIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9507119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="323" mass="38087" checksum="9218A62B53718939" modified="2023-02-22" version="1">MTLEDSITNNSHSIISMTESSRRTTNNNNHHHHHHVRGLPYLLRQTSRSMSQPTIPGGNNRYRCPHRERVQHRHRMMMYTTMPTTINQQQQQQHSCTEIDINNNNENVNRMAWYRTKIWLQYLATIAIRFIPLLISTIGVICLLAFLIDYEFALIIFNITLMIILVIVIIFIVYTFIMFYIYRKHSDRLHQTRRNRSNNNNNNNQNPGNNQQQTTTTTTTQRQQQQQQQQRNRSYSTNPNDLINHHHNHNHPTILTTTPSYHDDDENECYNCRMEPETSMEQQQRLSSSQTELAQQQQQQQQPLSSSTTTTTTNQISNEHSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW61</accession>
    <name>A0A922HW61_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW61"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="214" mass="25008" checksum="ED32A8890AFBE56A" modified="2023-02-22" version="1">MNSFGDKMKALFYGPGWAPGKPRTGLLSDIPPVDIHAPIERYDCEISFWESFYVMLHSFIIAMGFYIITDHPLVLESSRCLLFFPFDSYVMQPWIEQLTPPMHLHGFIDYMLGLIRLIHIVSIAVWLILWFRNARRNPKSFKADYCWPAIINPHKCISAFAYSNNINVINQRRPWAIALYAVTMVISLTFMFFIFALRFDHCNNIFKTSNNIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWK4</accession>
    <name>A0A922HWK4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWK4"/>
    <dbReference type="OrthoDB" id="3355217at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="260"/>
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    </feature>
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            <begin position="260"/>
            <end position="271"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9511038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="590" mass="66762" checksum="B8E4460DF0419F6E" modified="2023-02-22" version="1">MSYRKRRQSIYLQGRNSISRTNSYDGTSATAAAAAAAAISASTTGGTTLRINSHKASILIDNFSGLPCPDLKTMKCYKGYEWVTFRPVEILPPSTMMPEPLNTDDETIDEQQSEFKDLNDTSKDNDDKELSAPEIIDYRITRLSKDWIQKVGTDDIGQQETRECLHQHVKQKFCHGSKAAKEMSIIDIHHSLIVRYSLESVCERRQLCWTFEPFVDHDDDDTTDNQVPYPHSHQPADDPWKIPVHQVRDLEVMIEQMTPSLPSSTPQQQPSTPLPPIKETDDDVVDEVDAVVIEEKPPTQRTVTFLTIDKHPLSQDSLNLVASKEEQALKRKYQEKIFQDQCMEVTVPGTVSIHSCHICAGVGRKRCLVCVGSGSTKCDICEGVGFYGIDHNKPAFTRTFSANSDNGNDYCWRCRGRGRLRCDGCSGVGMTACIGCAGSGQIKCYIKMIVTLTNHHNSVIIRDKYSNEIPFDQIKLTDGDLVLNEDGLDLHPTSSLFHNDLITGQSERLIRLHRRKYLGNCRLIWQRHRIKVIPVCRVHSSWHGNRFRFYVFGRKSQRRCFAIDYPQRCFCIPCCCFCCCTSCSSPCRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYQ8</accession>
    <name>A0A922HYQ8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYQ8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="199" mass="23460" checksum="E51BE308D2A3034A" modified="2023-02-22" version="1">MITKFPITITILIIIFIDNYGNAIDFELWILNSTFKTTTTTTTTIATSVNNKMAKDMDDCYRKNLRLFKRCDLDFENHLEDYDNVFNDDMMIVVDNDNLSNDQMQKICCQLIVPYQKCYNNIAIRKNCKHKSIIDIQKHLDEYLLRKYPFINCVNYDNNSHNNHCFNKILFWSLVAVCTIIGIIVTGIVFGYYLWNFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYZ0</accession>
    <name>A0A922HYZ0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_007947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYZ0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="263" mass="32024" checksum="C5E4D1DDEE472AC0" modified="2023-02-22" version="1">MKRRRRQQRPPPIDTQPIYRFNWTALQWHFMLSFSLIFITPLIDVIIFMPTYMDIPRKEFHFSIWTAIIVALLTILANNDIHEQKELMEIRILPIGLFARFLFGFSIADLSLLTIQWLYIYCSWPYLYKNIRFIGYRLISGTGMFRIIDMLDEQAEQKFYVDKIIDYDGCALFLMQTIRLTIITAKVLLAHSIRWQISRRNIHIYRMMMKKSKQQRGRRRQRQRYERRRQQQQIWKDMQISLSFATLIIHQGEFFIRRIFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZM2</accession>
    <name>A0A922HZM2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZM2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9515813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="337" mass="38567" checksum="2528ABD034EB719D" modified="2023-02-22" version="1">MKLSHVYDFRNYILEYSRILRNFFQNMEEKSGEIGRLWTVSIAVPSSIVDNAQSAELKSYLVGQIARSLVIFKIDEIVIYDEYCIPGTPEQVVLDKRKETMVQTLRILEYLECPQYLRRNLFPIQKYLQYAGLLNPLEAPHHLSSTDQCPYREGVVLNKPHKQGSFVNIGLRQECQVDRSLQPNVRVTVKLETNIGDSKKLRGKIVSPSEPREKLGLYWGYSIRMANSLNEVFDGCPYDGGYDLKIGTSDKGDNVDKKIKKIPFTSSIHTLIVFGGLRGIESAHESDESLSHVQDTSELFDYYLNTCPNQGSDTIRTEEAILITLSTLRRRLFKQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0V0</accession>
    <name>A0A922I0V0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleolar complex protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NOC3L</name>
        <name evidence="3" type="ORF">DERF_010228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0V0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="2">
        <location>
            <begin position="56"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="653" mass="77579" checksum="D950C9F0EAEC4ADC" modified="2023-02-22" version="1">MISEDDYDFDMIDPEIIADDEMMKSSETFREKPIKKTNATLVQKFAERQKTIREYRRLLASISERVMSDPQHNIHRLKQLLTILITSRDDPRIGSAFFTIQKLTILALNIIFLDIIPNYRIYKRGEQTTSKLKNETRHVLDFEHRLLQYYQEYLKRLKRVIGSVVDSRKQGDSDFYRTMLTTLEARQRLATIGCRCVSELISRHYDFNCRETLIDSAAKVLCSNQATNEMQQTIYDGLKILFRKDLMGETTLVLVKSMTMMIQNLRFRIRPLAMSVFKNIFYREIHENESKMIGKNRKSNNQPSRRDRKQTKKMKLLEKQLLETEATESQQVRQRHELNIHENLYAFYMKFMTILHETLLQPNGNDLDRWYRPLLPIALESIIHLALHSNEEFAYAWIRKLKSFLESVELAEKFQPYDKLIFMKNIYTLMSRIESTASSTTTNQFDFKHLYQVLYEFPIDGQDGQTFRLYLQCIHVMIIKSIRHHFLIDRLINFVYRFLSLATKLPSPQAIVLLYMARKCIQLHPQWPNLDDDDDDYNNNKHMNCKNWTLPKNVDGDTLINQNPMDGRRKSMQTILAIIRMLINESSDGYIRLYASCVQEDVWHKNRQFLNHQQQQSMMNKFIQKHQLDRNVCERLLSGNIEPLDLYEQLVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I133</accession>
    <name>A0A922I133_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase AAA domain-containing protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ATAD5</name>
        <name evidence="3" type="ORF">DERF_010345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I133"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061860">
        <property type="term" value="F:DNA clamp unloader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="221"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="614" mass="73329" checksum="7A9F116537CCC3C0" modified="2023-02-22" version="1">MKENKREFNQFYSILFSREFSRILNFHHYFTIPKMSSNKITDYFIKRSNVLYNSSNNKNENNLSEYRKNGKNVKTKTKSPPKIIADYDDSTTDIDDDNLTEIDIHSSSTEVIDDDENEPPPATKPKRKKKQQVVIRKSTRKINNETATNVDPVIQSSTIDDMNIWTQKYRPKTIDNMIGQTNEIKTFKNWLENWDMKFNNDDKYDDEDDDDDVDCVGKCFYIFGSNGIGKTSMVYAVAKDCGYNILEYNATIKHLTPKSLQNELYESSQSYLIDNSTWQNNHEQIFNGFSKSLILFDDIDAIIYENKSLNELWRSLKTIIRYSRKPIVITSDLQPSFLCNEQNFFHIIQLRPVRFELIIEHLDQIFNMESIDNKLTNHNGDFYGILFESNDLRKMINQLDFWFPHKQIHNHHQSQSLETNLKTYYQHYMNKIFMNTEKSLDKQSKILETLSNDDLYQTNIDRFLNKNDEMDENRYNAYSIDKRYTLINENDNSNNNNNNHHHHITMKKFHDDHLWLYQCDHNFICTQMTTDLTFESLQMIQDYYKYNDLYSLTKFDYLSLFEFVIESFPGLFSSLYPLHCIIPHDDESNQHKHRTRSSQKRKRRLQFIQIEYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1P0</accession>
    <name>A0A922I1P0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_008078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1P0"/>
    <dbReference type="OrthoDB" id="10458340at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017245">
        <property type="entry name" value="BLOC-1_complex_su-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31974">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31974:SF2">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15753">
        <property type="entry name" value="BLOC1S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9517402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="232" mass="25827" checksum="7512D0B39B14D645" modified="2023-02-22" version="1">MHRRSAVRNNNNGKELRTLVHRKDNSNNKLSAVVVIGEASESDDNDDQLDQVQIIDDVLPMAEDITAGEVKQTSFTSSESIGHERPNMTETNATKNTNQYANDKQKNNYKGVTSISSPIPQSSGTKNRPTLKDSMTTASCHHRQSSNSSLLHSLLKESNEHVKQNLIKVSCSPYLMAQKKYSQIIRNLLSTQKLLQTSCQLLQTINDDINQLDKSFITLSSTIVANNNKLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I244</accession>
    <name>A0A922I244_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_007829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I244"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="222" mass="24646" checksum="35C257EF21A2986F" modified="2023-02-22" version="1" fragment="single">MMLPSSSSSSMTAQYSRQRCRNRHHQNGQQQYYNLSSNSAIIITSPSPSSSSSSSSSSFVTSRPTNSTIITTTQQSDHDINSKSLSLSSSSSSPNCLPPPPPSLLPSSSYKSTLSMNSRKNISTTKLKSKKSSSIQWSPLLLLLYQQRNRSNKSNNRFNPFIILKNHNSQYHYYSLQILFILATIFISLSIIPSTQVTAQNFIILCDDDDDGSFIETHTDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2C4</accession>
    <name>A0A922I2C4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Citramalyl-CoA lyase, mitochondrial</fullName>
            <ecNumber evidence="4">2.3.3.9</ecNumber>
            <ecNumber evidence="18">3.1.2.30</ecNumber>
            <ecNumber evidence="19">4.1.3.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">(3S)-malyl-CoA thioesterase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Beta-methylmalate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Malate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">DERF_004417</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Derf</strain>
            <tissue evidence="27">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="27" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">Derf</strain>
            <tissue evidence="27">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(3S)-citramalyl-CoA = pyruvate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22612"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58668"/>
            <dbReference type="EC" id="4.1.3.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:87810"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="4"/>
    <dbReference type="EC" id="3.1.2.30" evidence="18"/>
    <dbReference type="EC" id="4.1.3.25" evidence="19"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2C4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047777">
        <property type="term" value="F:(S)-citramalyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106064">
        <property type="term" value="P:regulation of cobalamin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000014">
        <property type="entry name" value="Citrate lyase subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040186">
        <property type="entry name" value="Citramalyl-CoA_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11105:SF0">
        <property type="entry name" value="CITRAMALYL-COA LYASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11105">
        <property type="entry name" value="CITRATE LYASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 25" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="26">
        <location>
            <begin position="53"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="27">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00066460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00076788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KAH9520726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="357" mass="39952" checksum="90AB82C44FA1C7E3" modified="2023-02-22" version="1" fragment="single">MIRSRIPFLFVKNLFRSRIPSSSMIIRFQSSSSSSSIDLNSMTQSLNSSLLRRAILYVPGNDQRKIDKAIKSFDKIDSIVLDCEDGVAVKSKDDARKTILKILNQHGSNELLWKKLSVRINSMDSGIAVEDLAIIFSGKIIPRTILLPKVDTKSNIDEFFEYFQKAKINKNIIKHPIDLITYVESATGLLDLRDIAKHTIDMCKSLNDTININFAGIVFGSDDFCANIGATRSDDGKEVLMARQHVILVCKSLNLQAIDSVYINFRDIDGLKRQSEDGASMGFTGKQAIHPDQISVIQEAYRPSDNKIDWAKGLIDEFEQAQNAGRGAFVYHGQMIDMPLLKQAYNVMNIAKQIGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2K3</accession>
    <name>A0A922I2K3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PNLIPRP3</name>
        <name evidence="8" type="ORF">DERF_007014</name>
        <name evidence="7" type="ORF">HUG17_1512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2K3"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="84"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7645974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9516260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="354" mass="39524" checksum="6E645F1C0A125814" modified="2023-02-22" version="1">MATVGRMAENQIHKGSKTSSSFSSSATGKKSTQNVSKSATNATNSFQPMSLEEIQPELIAYGPNGDMITIQHDVPAKKAFQLLKDGNMLEFPRIVFITHGFWGSARSKWIHDLKQKFFEESDQTFIILGWGKGAELPAFKYAQAVANVETVAKWFSNYVLELKRKNITKNISKGSIWGIGEGIGAHIMGLAGRWSQHAFNRITGLDPAGPGFELVNENLMLRSDDAPFVDVAHTDSHHEFRSSEHYALINKYGTLKPCGTLDIYVNYGYNQPNAADFTNAGSHLRSIELFAWSIENPGELRTQFCLKEMPVIDRPVDKVKRTVQPAEMGYWADPKATGCYYLETNGEEPWKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I344</accession>
    <name>A0A922I344_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase-associated protein rtf1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RTF1</name>
        <name evidence="8" type="ORF">DERF_004804</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I344"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="7">
        <location>
            <begin position="326"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="582"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="703"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="505"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="616"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9521131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="736" mass="84483" checksum="D597E70271880665" modified="2023-02-22" version="1">MARKRNRSSDDSSSASSSSSDEDEIIDSRKKNVKTASKIIPTDSSSSSDDGDDGEWNAKPKTKAKSKRNKVSKKQPTKVMKKKLKTASSASDDNDDDDDDDNNDDDDDLLQNSSEEKEEGEVDFSDDENEEFNDGFDENLMGDEEDQRKLAQMTEKEREQELFNRSEKREVLRTRFEIERKLRLAKKQEMKKKANEKQNDKNVDSTFTESASRSIERRRNMEDKRKVKDAMKGLKAEREKKKEKLKQKLKATDVYSDSSDSDDSNSDIRITKKDRKKSSTSEEFSSSSSMSDDSDVDTKGKLNKRDKDDWDNERSTDHIEDVEQFDFTFEHLNSLRLSRFKMEKWCHAPFFRDTVINAFVRIGVGNSSLSQYIVGQIVDVVETAKIYTLGKTRTNKGIKLKHANDVEKVFRLEYISNSEFTETEFQQWHSKMIADKCDFPTKDLVERKKADIQKAINYNYSNEDIELIVAEKERFKNKPTNFAMKKTQLMKEKEFAEMNGDHEKAIEIGKEIDRLEEESKKLDKKRTQSIASISFINERNRMRNIKEAERAIAEAAKEAQNQKDDPFTRRKCAPTMIHVFNKNKQSQSNQSHSNEANEQSSKDIESQKSSKDLSEFNENSDTLDSSNTNKNNGSSLQSQNNHSKSTNNTSQNNEDNNDMFSVHNFDIKIDFETLDFGINNSNSSSISNQNSSLLFSGLSSSKPNGFSMARSNPLPNSGTNRRSLNLDEYKKKKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I359</accession>
    <name>A0A922I359_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium load-activated calcium channel</fullName>
            <shortName evidence="14">CLAC channel</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TMCO1</name>
        <name evidence="18" type="ORF">DERF_008405</name>
        <name evidence="17" type="ORF">HUG17_2543</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Calcium-selective channel required to prevent calcium stores from overfilling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TMCO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I359"/>
    <dbReference type="OrthoDB" id="342726at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008559">
        <property type="entry name" value="TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20917:SF0">
        <property type="entry name" value="CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20917">
        <property type="entry name" value="PNAS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023322">
        <property type="entry name" value="DUF841_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 14" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR023322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7638510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9517772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="182" mass="20966" checksum="09C1B4BD68CF37F3" modified="2023-02-22" version="1">MIPYDAILIVLISSFTALFGEGLTWLLVYRTEKYKKLKNEVEKRCKKLEKKKETMGETSDRQQKKKLEREEEKLKNHNRDLSMVKMKSMFAIGITFTALLSMFNSIFDGRVVAKLPFVPISWVQGLSHRNLPGNDFTDCSFIFLYILCTMSIRQNIQKILGFAPSRSANQQTGTIFGPMPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3Q6</accession>
    <name>A0A922I3Q6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3Q6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9518072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7743" checksum="E053F58EDE8C0865" modified="2023-02-22" version="1">MMVRYGSMPRSKKPEPNSELVFSDISITIEFKENSNTRIDNNNDKFEQQKNVPQTQTNDTVRCSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4K5</accession>
    <name>A0A922I4K5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PTB domain-containing engulfment adapter protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GULP1</name>
        <name evidence="7" type="ORF">DERF_008494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ced-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4K5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043277">
        <property type="term" value="P:apoptotic cell clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01273">
        <property type="entry name" value="PTB_CED-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000118">
        <property type="entry name" value="GULP PTB domain containing engulfment adaptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF77">
        <property type="entry name" value="GULP PTB DOMAIN CONTAINING ENGULFMENT ADAPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="6">
        <location>
            <begin position="160"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9517876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="589" mass="65421" checksum="F4618609D9973D09" modified="2023-02-22" version="1">MSSFDQNKVVSIFASLCFVDCQCFFLYCRATSVIFLAFHLFSNSIDIYHISYYPMRMIKHASLFKWPQTNGGASKMTNSTDSVIGTSIGSNDNGTSSSSNNSNGNGKSKQHQQSSSSSSSSSLSSQQQQQQQQQQSSSSSSTQQQKLWIHPPATLQNGHIAYLVKYFGNVEVNQPKGIDVVKESINKLKFIQPLKKSEGQKIPKVELTISVNGVAIQEPKTKKIYCQFPLHRISYCADDKNEKKFFSFIAKDSDTDKHLCFVFMSEKMSEEIILTIGQAFDLAYAKFIETSGRELEIRKQLIILQKKVCHLEEENKTLKERLRKYEPVSDSTIDIDDGHHSDNNNTKPSSLFSSSSSSSSSPLSSASSNNNKNEMNNGLDLLSDDIVNVTGNNKDSTMTNGHSMMNNKLKSTLNSVQVPPLQPPPSSSKNHRSNQQINLIDVDIECNDNTATLLNHDNLLSLNNSQSINDLFDEDFNPRAEDNKPINTNNNVPIVLANNLINNPIVVANNQNISPIDQNLLGVTISQEKDIFGCEPFHQIKKECDPFGMPQFNGSTDLDSAIDNIDKKLAEMRDGFSQGLSADGFNLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4Y8</accession>
    <name>A0A922I4Y8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="287" mass="34279" checksum="89CE7525080B3231" modified="2023-02-22" version="1">MLFFIRNIFWILLLFISCLSLIIEWFNLISKQQISIITMANNRRIKFCKLDHLIECFIEPSLFLSAQSNGTGIPSNVDDFEQFCFNQHDYGPYCARKWFHRCGTPLHSIFFERLYLQPFQENLRRFCQPNGTIQNVEIIQDFLNISSCLIDKVKLTDEYRHRCIYRLQTSYEWIHDQSRQNANFTKFYQNTCCAYYDWEHCVMEMLMVKCGRQSQQMFHTMIEYNSLSILNSLCPRDEYDFGKQQCDPIEFHAPNDYHPKGIHSNSIVSYLFSYYCPNIGYGIDDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <name>A0A922I5A8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5A8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7318" checksum="1FBB5AAE10D8BC66" modified="2023-02-22" version="1">MIDLRSILIKGHEKKTQDVRDHFSNDANKIYKLDIHNNKEKIEIVENHYAVIVVASSHSDFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5K9</accession>
    <name>A0A922I5K9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5K9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="6962" checksum="AD3215D3D1BA0213" modified="2023-02-22" version="1">MFLECLPIDVEFRRDSRPLLPVSAAPVPLPLSNINPDDDDGEFVNGSLAVTLIISVAVEIFEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6B0</accession>
    <name>A0A922I6B0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005171</name>
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    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
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            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6B0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="141" mass="16222" checksum="D4A20FEA26E7718F" modified="2023-02-22" version="1">MNRDDKDLFHFGLSNFDNDAQTNEAIGYPMAAMCVRMSSDQSVLHFTPINVASYVLPRPASRNHNLIVSMILAQCCFEMKKKMPCTCGSSNRIMLESDSKENRRQSCTSVSVKFHYYEVELMLFPCYPDIIKAKFQLQNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7Y5</accession>
    <name>A0A922I7Y5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004737</name>
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    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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            <taxon>Sarcoptiformes</taxon>
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            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7Y5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7232" checksum="47984CD2D67C6FCB" modified="2023-02-22" version="1">MNHSLLVNIRASMLRVFTNKRMPLSKPLCGSILRLNMIIDPMFNPSILGIIRLNNRNNLPNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I823</accession>
    <name>A0A922I823_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I823"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="110" mass="13377" checksum="5A8D38D89356D437" modified="2023-02-22" version="1">MYEDKEKKITWQWKWKRHNFRFTPTQPPSPSQNQTEENCSRDQTLIWISIISTTVSLLLLLKRNQSEPKEKKQQTIELHEHMTNDESKYGRKTKKKQFYLLHDSDCFSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8W4</accession>
    <name>A0A922I8W4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclin-dependent kinase</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CDK6</name>
        <name evidence="19" type="ORF">DERF_000534</name>
        <name evidence="18" type="ORF">HUG17_8319</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
            <tissue evidence="18">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8W4"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07838">
        <property type="entry name" value="STKc_CDK4_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000205">
        <property type="entry name" value="Cyclin-dependent kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF472">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="54"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH7640850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9526442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="349" mass="40102" checksum="CD642BC484581257" modified="2023-02-22" version="1">MDNLERAKDENLIKSRQQEQVVNEENLSINDNKTNNDYGTDINHNSNNNVKKKYEEVALIGSGAYGTVYKATDRHNEGQFVALKKIRIPMTEIGVPVSILREISVLKQLQTFDHPNVVKLLDICHGHNFELEKQFILFLVFEHIEQDLSSYLHRCPAPGLSMDKIKDLMFQIMTGVDFLHSNRIVHRDLKPANILITNRGQVKLADFGLARIYKQAQQLTAVVVTLWYRAPEVLLNTSYSTSVDIWSCGCIFAELYNKKPLFCGQSENDQLCKIFDTIGAPDQNEWPNDLLIPWNNFANFKRQNLDNIIKDVCSDGKDLFKEMLIFSPSKRIGARQALNHDYFKDLRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9W8</accession>
    <name>A0A922I9W8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9W8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="243" mass="28893" checksum="0F0406E746E77FFF" modified="2023-02-22" version="1">MPNYVQRKMRELNCMGRNHQRRHYGSIETIDSDVYNNDDDDQQQVKRPDGKRIGLFRSFSFINKKKKSQSQQQQNLNESTTTEFNKKTEKTRLILVGKKKKTVNSKNYSTLIESDDDNDDDDDTFESIMKNNSKKSVRFANNDNNNDDDNGSNRKTWTKKNKNRKNKKKKSLLKRTGSLIVRSCRLMTYGAPHMPYNMPYNDCNGPYHYDFYRNYEYYDDGYGRYDNNQYMRYGEYGPGSIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAA4</accession>
    <name>A0A922IAA4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Oxysterol-binding protein- protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">OSBPL1A_1</name>
        <name evidence="12" type="ORF">DERF_001818</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAA4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="5" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="7" id="KW-1053">Target membrane</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="305"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="364"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="669"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="747"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="560"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9527824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="778" mass="87514" checksum="7A170226F7AFEE7D" modified="2023-02-22" version="1">MFSSYQPNNNNKQNEQQDDKESTISNADLHDDQKTEQKIQPLKLDAQEFYDIHEDDLVDFETSEEFLLHFSRIGQVQLVKKLLSLRNAHEIALNIDCKGTVKANFGWSPLHLATYFGHYEVVEILLKNGADVNIQNEEGDTPLHKAAYTGRENIVILLLAHQANVFISNGDSLRAFELAKTDSIQKLLSAAEKFDIKRREERYLSAARSGQISVIKELLEDTNNGININCTDSSGNTALHCAAYRGQTEVVIFLLKNGIDTAIKNKRGQLASNVAATISLKQLIQEAHLSVMTPRVVASLKNKSVARFEGCLLRKARFFGWRPVWVILERGVFSYFQNRADAATGVRRKGYKYLDNAITEVVHDNVGNNNSNSPSISSSISSNLDHKHQQQSPSPQPLCFIIIFGDRSRAMLGLPKNQSELNLQKWINAINDHIYFSTNFIKQGTHMGDDSDDEEEAAKQLLSPMAIQDMIVTANAHQKILERHINALQQLLNDETLFFSPERNRDDQFSNDSFHSVQSIDSISRSTIPSIKFHLNLILESSKNANSSLTQCLVLISHQNQSRQTLIQQEQEKVRALEEALQLLAHEHHDLERSVTRSILNSTARQQHSISTSMPTDVAQNNSIIADQSIHNSNLISLNQSLVRSFACLSQTSMATDMDEFYDAFDDAFDDEDDHHQHSNSNPQHPDQIVHCDSSSTNNNNKNSDDRIIIMDSIDNKNEPLNQLKTLTTFHTANDNSEQLNDLTINDSISTLSPDDDDGDADKTIASDDLPLNSMRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAZ4</accession>
    <name>A0A922IAZ4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_000817</name>
        <name evidence="8" type="ORF">HUG17_8551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7641082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAZ4"/>
    <dbReference type="OrthoDB" id="6490954at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7641082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9526755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="513" mass="56281" checksum="4E2FA9E21E7B86B3" modified="2023-02-22" version="1">MPLAESADCTDHLQALVCENNNNVTVITTSESGNHNNTTADDRKNNSLTSMQTKFIIVLLAVCNFFIANGVSLQGPFFPKEAEQKGATPLIYSSIFAIYELVMLITSFLFGNFAEKFKANRMSGLGLILTGLATTVFGFLTYLTIEIEFVTVAFVLRIVESLGATAFATSSYSFISVCFPDRTATMFATMEMFFGLGVITGPVIGGFLYNFRGFLLPFLANGIIIGIFGVVLISSPVEKLFLRGKLLGQLNGQHMDNNTTTINDDREFNTLIVPINESSESSTINNESQEENQQVTLGRFLSSTIVLIDAFIIITAITLMGFNGATLEPFIRHEGISNQTLYTSLMFVALGASYSISALFWGKVCDKFPSFLICFAIAGSIITGIGLLFLGPVPFLTWTIRPKLWTISVCMILFGIGTSSKQVSAYTHALNHTINDRKFPKNQKTYGLISGMFFSCLSFGGFIGPIIGGSLLQWSDFHYATLVMFVLECIVFVILLLLQCFYVSITTTTINQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBT0</accession>
    <name>A0A922IBT0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Formin-binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FNBP1</name>
        <name evidence="17" type="ORF">DERF_003034</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FNBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBT0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07653">
        <property type="entry name" value="F-BAR_CIP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11619">
        <property type="entry name" value="HR1_CIP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11911">
        <property type="entry name" value="SH3_CIP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000203">
        <property type="entry name" value="Cdc42-interacting protein 4, isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000002">
        <property type="entry name" value="Formin-binding protein 1-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057870">
        <property type="entry name" value="HR1_TOCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF12">
        <property type="entry name" value="CDC42-INTERACTING PROTEIN 4, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25610">
        <property type="entry name" value="HR1_TOCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="15">
        <location>
            <begin position="43"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="16">
        <location>
            <begin position="422"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="679"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="337"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="525"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="607"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="143"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="607"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9529132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="765" mass="84986" checksum="9D3FB21BF8F0E645" modified="2023-02-22" version="1">MLSTTASSPYHPHHYYYDDDPSPLTNVHYPPQMVNHLHYEEEHETFEPFVCDFHDQYDNIASHTNKSIDLLDKYGQFSRDLAAVEIDYAAKLRRLAKNYQIKRKDEEDNMCTVIKAFNKSLKEITDIAGQHEIIAEELSLNIVKEIGTVLKELKDERKRYLQEGTKLQNSLQQTISMLEKSKRNYEKAFRESEKAHENYLKADADLNLSRAEVEKARLISLSKSSMCDDAKSDYATHLQRTNDLQRQHYTELMPRVFHQLQDMEERRSQCIRNYIFQCAQIRQKVMPIIEKCIDGIVEASELIDPKEDSRLVIEKYKSGVDPPGDFPFEDLSNPRCIDDSISNGDSSDGASVHSSNGSNGHNGLSHHKSSTGSTSLHYSKSVCTDTFRGTLSAAKFRKRGGIFGIFSSNKSGHDESKEDFSDLPPNQRRKRIQSKIDLIQSNIQQENGVREALLKMRQVYQDNPKLGDPQLVNTQLTECMQKLEKLDADLKKYQTMLSGVLGSTPAPGSQNRSSISSSATIHSTNVSTTTMNGGKHSTPNGQTLNNHRNSISDNSNDSVSRSESETSLHNHSNGSNGSPYGSSGGGSSVQTGLMQAANSLFNKYSINPSATTPTSPYAKTNGNMNGTSTMSTINGGSLNGNFVNGKAKSDQDISLNESSHDDQTTAPGADEEDFEDTIVVLGMAKALYAFEGQDEGSINMDEGEEFDLIELDQGDGWTRVRRLRGDCEEGFVPTTYIECNLYDNMANKGHIAITAGNGTAATTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICA7</accession>
    <name>A0A922ICA7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
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    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICA7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7184" checksum="4F5CAF46A1D53032" modified="2023-02-22" version="1">MKIESQYEQITSSQHAKIYTYDVDILISMGGRGGLKSITKKINTESNIDQIDIILINNHHNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE60</accession>
    <name>A0A922IE60_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
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            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE60"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="516" mass="61171" checksum="039C7C7233D55DEB" modified="2023-02-22" version="1">MFYDYYEYDDYDGGGGGGGDHDDESSHNNNVLFNGDDANNNNNGGQIVLMKQLLPVDDNDDYYGQSDQTIFSRSYLKQVRFEASQYHDYDDDDDDDYNNNTVVSATKTKTTTTTLKSNRQQPSTIINNGNNNIWTCNKLIRKILYNFRYARKFIQCYREQIQENCININTNNIHDDNNNHHHHYHHHNDNNNFNIAKAIRTKQWWLQYCFGYNCGNNGDNSSSSGNDDDDDDEDEDDCYVGGISDFHHFMNNNGQQQQQQQTIIDMDLKQIEFIENILWSTTTMNIDNGDYLDSSIIQRHHHQQQQHENNMDAYTNGHWPQITFLAELDQMEIIKVLRLLRRWINRNDDDNNHNEQQQQQHSNIGHWLYCLLTLLDRIQTANVYYELRLLFQTCNRQRIKILLLAANRLKNYYYCCCGENPDHNHHHHPPPQQQQQQQNGRRKTMIYRQQQKIQNEKSRRQQKSQNNNNNNNNFSSTFHQQQKIIHPLKDQYCAHCLIMIIIIHFFGQKDLLDSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEX9</accession>
    <name>A0A922IEX9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEX9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="7126" checksum="A85B39170F251642" modified="2023-02-22" version="1">MIQDILRTYEDSIIQMNMVKKKNRKILIKIFFAIVIFHFAKTRSKLPVLTINDNMALDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF25</accession>
    <name>A0A922IF25_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF25"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9530356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7604" checksum="DA67C2B23FE89F03" modified="2023-02-22" version="1">MNKYHSLIRKYQIKELYGKLAHLCIEKMLPKITDSLLRDNENSLKFLDWFYDQRSFIEKSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG41</accession>
    <name>A0A922IG41_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Scavenger receptor class B member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">SR-BI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">scav-3_2</name>
        <name evidence="15" type="ORF">DERF_004168</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Caveola</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG41"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF110">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="600"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="645"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="656"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9530357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="687" mass="79369" checksum="B13E63FB93E826CA" modified="2023-02-22" version="1">MERPPTESIDINLFQDDFENIGQEFLKSVVSIFSFFTQDLEKEFLLTKEATYAYGQGRPRPIQTWLNGKELFGCIWCNHFSFYPNHMILHIIMDCMKKLTNITNDNGHKNRHNSRINETPKQSIDYHHCHPIDHQPDTSRKHEIRSFDIMSLLNQKDRKSSIEDHDHDDDYNNNQDVDIEIDVETLDDDNNNNNNNDDSGSMIAAYKIPTMMMMNNNMNGQKRSKRSSSIPTRPPLSSSSIVSNQYQTPSSVDELLFSGYKSELLCELKRILPKQVPSCYFSLMSNQNDTWSEPYVQYTGHDQIDRLTTIISFNGSSKLNYWRTDKCNQINGTQNGELFPPAGQFGQHKIYQFFRPDFCRTFNLTLNETNIQSDVGSLRTDRFHLDRHSFMNSIDYPPNSCYQSKLSSIKMAATTTTTTTNASTAATAMDNDEKQRWKRTIDQLLKTFKLDSKEINHLLHNQNSTESIDDNKATMIMKQPVIKPSGVFDISACQQGAPIFIYNDISLPHFLDASDYYRKQLNGLHPNRTKHESYIDIEPQTGTPVDFIARIQVNVDLQTAGTSQPKMASLIMPTMWQSLTIHITQEIANTIEQQTKQPRIIAYTVAALILIIGSIMLIYSIFVCVLYYWHRHHLDDDYNEFINDDNDQTSDPLITNNNNNEQRQQQPQSNEIMTSTDHDDKYNGYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG62</accession>
    <name>A0A922IG62_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U3 small nucleolar RNA-associated protein 15 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">UTP15</name>
        <name evidence="11" type="ORF">DERF_003637</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG62"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="10">
        <location>
            <begin position="391"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018260"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00045437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9529770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="529" mass="60238" checksum="354BC24A3B7E8E18" modified="2023-02-22" version="1">MTTFKPTTVSTLPAIIEPLSESAKFWKNNVNPATVYRELNAINWIDINGHNQILTTSATKVSLYDPESSEKKRTFQSPNHTLLYGGNFRRENQKIFATGAADGIVRIWECKKSKPLRLLGNNDNAQSLKHSAPVHRVNFNGLNQLFSCGDDKQIKLWDFIEEKILYNFNSDSSSAHDDYIRASCLIESASLFVSGSYDHTVKIWDSRSPQTSCYQYGHKHTIESVTNRDLLVISASDTTIQVFDVVAGKTLRTLDNVHHKTITCVHNYGTYLLTASIDGHLKIFDFNFNVIASFSYTPSQLLSCHYNGSYLAVGTNNGILSINKISPQPKTTKGRSAQHGGDKIRKQDDADDDEEMANEFLFSNIPKRKTVKLDKKNMFIVPNVASNNIINRPRQEKQEELLRKFQYTAALNRVMRKFANNDPEKVVNFMQELIRRNGLQSALAGRNVTDLKRIIKFIITHLSDIRFSRILLDVSLILVNIYTSDIRHVEKVRILFKELNQRVDDEIDNLQKMSEISGQLQFLINSQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KTG6</accession>
    <name>A0A922KTG6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KTG6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="228" mass="25804" checksum="1E1093E6DAB86953" modified="2023-02-22" version="1">MKNIFVLITTGIWWSSLFFISFISLFQHYSTYPMPQMRICIQSIDPTRLPSQCIYCKSRTFPITVRMCTGNSYLPARMTLNEASCLITTCRKQLPRYPPEPYSYIRPMANNNIGYNNNNNHNNYNSHNNNNAMHNDPINDDDDDNDHSNDHTNGSNGIDDVGGNNGGNDIMEHPSTTIINKIRKPAKFFLGKPQKIQTSTITQPLQLPAAASFRRNSFHISSHSAAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVX6</accession>
    <name>A0A922KVX6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVX6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="126" mass="15007" checksum="2233153EE278BBF7" modified="2023-02-22" version="1">MQTTTTTTTTITKLNLNCSTTNDESIENYRLYSIWNRLENRTEKLWHQMNRGWKSIDEQFLLLIIIMLFMIIIIIFLIGYICKISRKNSRKQLKKISKNLNEKCYLLLSTNDNDDDDDNDYGHVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KWB5</accession>
    <name>A0A922KWB5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KWB5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13270">
        <property type="entry name" value="PROTEIN C20ORF116-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13270:SF14">
        <property type="entry name" value="SEX DETERMINATION AND DOSAGE COMPENSATION PROTEIN SDC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="869"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="813"/>
            <end position="832"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="909" mass="99765" checksum="570CBAD8159C7656" modified="2023-02-22" version="1">MQRIRDTFRRRGGTSGGGESSSTSSTSSPAAIITTTGYYSSTTPSTLEQQAKAEACRQQNRHRRQMLLLQQQQQQQQKIMKKHQHYRNNSGSNGGGGGGSLYGGANIGSGGNIHTGFSSSTNSTPTHLASSIGSGHQSSSQQSSPSHSYTEEIITGIGNTAGTTSGGGGGVGVSSSGGGGGGSGNFWCSTGGIYPYDMTMTMMIEPRRDVQQIQQQQYRQQQQQQQPQSTSSTPSPLKLSSSTTIIGIDDDDDDNQHHFNFEINNDQSNSNNNEMMKTCLNNNNKTNDVIITGGSGNDGTLIIDEYQQKSINTKQLMVDIQSTKIDYSSPSSSLSLQVPYNKTRSASFDDSRQVVPNGGGGLCVPQDARNVRSKSFDHSATMYSNGNPSQPQPPIQQTMNKSQTIINSDVTNRSTMTSNMMMNKRSDSNASNTSTASTVVTFLDVPKWKLLIRRSSATNNQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQSSTTTNSNSSNDYYSQLSLMCKDCIHCQYMYELIQEQQQQLQQQQQRLPTVDEYGRSISPQSESIDDDQNSPSSDHSSYNDDDSSQQQQQQQLQQQQIHQILTTESSTDSKRSLDRTESNGTVGQLEAMDEFDVDEFIEPIEGLPIVTLCPPELSITDTATTSTGSSGGVSGVGGDSNCNNNNDGYNIQQINNGIDEEDDDNGSGITVVSLEVPIMGQNSSKQSRSASVDSPYLLQVPKRDDIEVGEGPPKARSKSVDIVLPTRPGGPYLLIPPRHPPTTTNSKNSQQNGRKNNHHDHQHHQQKQNNEKSADILMVKTKKSEISSTSLSSTITSSSGTLSSPNLNSTFIIDDDDDKNCLSLNHCNGHYKSSKILTPKSEIKNNSDHHHHHNHHHQRRSSLPFKFCSKFHHHSDTFDSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KWT8</accession>
    <name>A0A922KWT8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_013677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KWT8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="103" mass="11193" checksum="961F2DF70E04B8FA" modified="2023-02-22" version="1">MSFKATTTTTTTTTTTKERKKKLNERQIDDDGDGGNDLYFSRGRRPFDDDDDRGGGGGGVGVVGNGGVVVVLVIHLTNKKATKQYRTFILMIKSSKKKGGSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L074</accession>
    <name>A0A922L074_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L074"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="9702" checksum="4F3D34791C09B182" modified="2023-02-22" version="1">MDHILNFITSYFVLGTEAEQVEELNQKCQELTRRIDYLTNSHGINANNIIKIGKNRIAVHSSDLASSMMPNDDIKGIWYLCKTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0D5</accession>
    <name>A0A922L0D5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0D5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8650" checksum="BBBD913633A581F3" modified="2023-02-22" version="1">MECNMCEIFRTIAGYCDHLCFAWTKSHSGNYGNDLADFYAKKATLLPIIDYDQPSFTNVYRNFQSNMYGNWQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0H4</accession>
    <name>A0A922L0H4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0H4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7792" checksum="F9D63BA922C5AA27" modified="2023-02-22" version="1" fragment="single">IKPHHHLTSVSIGCLKKNWPTDSCTVGLFQLTLPQSAATIPHRIPNVTVFFTVHHVHRTLWPDFFAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0N8</accession>
    <name>A0A922L0N8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">tRNA methyltransferase 10 C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRMT10C_5</name>
        <name evidence="1" type="ORF">DERF_012822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0N8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9502021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="457" mass="55420" checksum="BCAEF335E762A4A6" modified="2023-02-22" version="1">MFKKLSNLVIFMKKSHHHHRKADKILSNHLLISSLSSKSHNEEYKNHDQRIKLYVDELFKRKLLPSRNVQYKSMNELQQRVATILERFDYGMYKNNLNNEEFDQYESTREKFHLKSEEIFEILSTQNDDDDRLLKYFINNRCQLYEKFLRRLNRSQIRQRRKQDQHADDGDDNLRSGIWSDQNELAYGLWHNCLFTKMKRSSLSHLYDRRLTSQAMYCPSTPRVLIDLDYAMDQDFFHTRKILNDVRNLLAVNKYHHINPFRIEFVRSSHHGLKNSRFDKIVHTFMSWWNDPKQYQYTIHHVAKPVNVLESDEKLIYFTPNAKIPLTMSELLDERNIFAIPCHNSRSLRDPVFNRINRLQYQKSSPQRIMVRRLPTTEHIVWNKFHGVISWSLFLTILHDIRHNQHDDWNSVFKRYLLENELIKSDDELSREMQNRQQIQIKREKQIVDFKRSINVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L101</accession>
    <name>A0A922L101_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L101"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7257" checksum="3088127FB7A05435" modified="2023-02-22" version="1">MVLFIIESRPNFDHTIVESLSLEFVSLSISKSTADTGVDFLDRDCEPIIEPLMDVISATSCHSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L139</accession>
    <name>A0A922L139_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L139"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052797">
        <property type="entry name" value="RegFact_GeneExpr_CellDeath"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936:SF24">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33936">
        <property type="entry name" value="PROTEIN CBG17840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9510577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="297" mass="33696" checksum="D6CEAAF81F65D7DA" modified="2023-02-22" version="1">MPISVCNVTNGPSQRLVHAPCSDASNGTSNVTNGPFQDQIFSSHQVPIVSRQHVPISVCNVKNGPSLNNDASIGKIPLHFCERCNQSFNSKWNLKRHNKRIHDYAGYLAVHLKSAHGVEIQVKILKFKDFEMFKSFLEKTKEETCSNYLTRRIERDSNQQVITANYICSRRGTIPANRSERKRAAKSNKTIKIGNICPSQISLTRIKDGIYTAKWTTTHVGHELDMKFGRLPNKYPSTTSSLSTKLTKEIVKNEKIHQSRNEYQNHILPKHRHQQIQPLHSTMITLPLSSTLVIIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1K9</accession>
    <name>A0A922L1K9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1K9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038128574" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="978"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1049" mass="119060" checksum="23612A01C153D686" modified="2023-02-22" version="1" fragment="single">IFALILACIAWLAQKFCALPSPSSSLSRHNDDGDSLPNSVHKQQQQQQQHQPKTIIIGTIQNGKTFTDDDYDGDGGDNNVKLNNCSINKNFNNRRCTNSQTEIRLRNINYRPIQLVNTATQTIIEKSIQQQEDYNPSLQKQDKPQNFFIEHQRYNYGYDSDQRSTSSIAHSEFEYYPIVGEDNYCCNRLQHQQQQQQQQQQQQRRQNRFSADFETDSDWSSVQSIPLAIFNTKMATTIPQSPIAVAPPPPPPPPPPMPGTSGALPMPDWRDLYPSQPPTSIRREHPPSKEEIEKQQYAHLPDKLLNAMNKDKKPFTYTPSGVSSEKGVLDLSEIRSPRMKKRLLANLHAGEEEENEDQPITKTDSLQNQPKSPNAHQYTASPFVLPPIPADAAQKLRPSSPSGLGCQNNLNNNKKEVRFAPSPIPMLSCDDNELISKLAARKQDVESRATIVTNNPIDDDTDGDNRQSQQPNFQTAEQKKFEPDMNQLCLNAAEAVRTARGIADMNDVNSNNHPHLNSVYGGNQMDELNETFQNQLRFEPSTQVQVANFQQQQTPTTFNTDVLKHVLDSGLQDEIDKFEEMGAKMGSTSPNLPPSLEAPNYCSRPMNYRGIAPPPIPPKPQNLMDGRTSCPPNPFSYNDNNNNNNNGQQKDFINSYRCISPSVDIWKRTQQNNNANGYNCSNSKPRPFSRSTMNETTFTNQSPLQSFQSPSNERTIPIRMDNGYSASLPRKIKLGQEFPQPRSYENPESGREYLQQAGMFSQLPPKQMDSPTQSKMFFGLNSRQQQQQQQQPLFESEHAKTYVDPEANREYLSQAGMFSQLPPPPLHHQQQQQTFTTFKSRQSSLPPLSNGNGISGNKIGPESPVGTPPINPWKQMAQMNNSGHRLSMSELRKLPPSERPHESAPLKYTGANIPSRSFRILQLITGEDVPNQFVQEQENDQRTNHHHHQQQRRQPPPPPPPRSDSYRPASQQSFRTPSTSQQFEQYEYQQTTIPRPESAMPMIGNYNQNQQQQQQQLLMNHYRNQEPQQQQQQHTQSTVYASSAHGTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1M8</accession>
    <name>A0A922L1M8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Agrin-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_010107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1M8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004850">
        <property type="entry name" value="NtA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03146">
        <property type="entry name" value="NtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51121">
        <property type="entry name" value="NTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037045026" description="Agrin-like" evidence="6">
        <location>
            <begin position="26"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="NtA" evidence="8">
        <location>
            <begin position="40"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="240"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9511659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="45378" checksum="411E23FB9829BACC" modified="2023-02-22" version="1">MNFNQQILLKILCLLLALIIINVDGQSSSSSSSYRLRRRCPTIFPTHKQLMNSNSIILIGLVEQIRPLDNIDYMDNSINRQPNYQLSQQQQQQQHSPIQSTSNYVANVLVRRVLHGQRSQLQNQRIQITGFNPNTDSKFYGGNQWCYPNTRQGDSWIFVLQPINYPDYFRLNSSLIKVTLSNIERLDSIIADQPYGLRIDFPECKFDECFLLILPCERKYCPNNANCINDPYGTDGARCECLTQCNHNIKYQPICASDDETYNNECEMRLRSCRSNKNLFIKAMNSCYYFYQKRPTNTITSSLSSSSSNRSIFPPNGQSNRYRTATMTTTTTTSSSSSSSSSNTNINNNQPMEMYRFNRPEYPLPDLIHNDKNRQSSSTTNRQHITINRSYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1W5</accession>
    <name>A0A922L1W5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carboxylesterase 5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CES5A_5</name>
        <name evidence="6" type="ORF">DERF_012600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1W5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036930655" evidence="4">
        <location>
            <begin position="31"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="51"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9501785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="680" mass="77636" checksum="10FF7C5826508A15" modified="2023-02-22" version="1">MFLFFDSSFLLLLLSRFLLLLLLLFSSMYSDDYSINCQSSSSLTSSSSVVEIQTELGPITGLRIRTYLNNRAIGFMGIPYALPPIGNLRFKKPIPYPKWYPKTLTANGYKPCCPQLDINGLPHGQEDCLYLNVFVPLANLPQQQQNPIGRRFPVMVYIQGESFENGDAALYGPEYLLDWDVIVVTFNYRLGILGFLSTGDEHGTGNWGLYDQLLVLRWIHDHIESFGGDPSQVTLFGQGAGASSAILHLISPLSTGLFNRVIAQSGSPLCSWSMEYNAANVAIELGRKIGCPIRRGNAELIECLRRVKLTVLLKEQQQGKIFGEYPHQFVPVVEEVGVAHERLVPNEPRRLISQGHYRRIPLMMGYNKDETAFLYPLILNKQMIGDQVGNLRTYLEEKLLPRFIRATILLNNGGKNTAYEMIGNNAYKLKTAIKDYEHDIQQNILFKYFNFLNSKNYPEMAFRFVNMSTDALYGSCIDETLRLYSTAATSSKQNLNVMGHFLSLPFTNITYKYVFGYRGRNSMLNLILQGNHRQLIGYNNRGLMWWPSNNNQEFDPTSNAVCHGDELFYLFNLKFSTRKPQDNRDALIQRRLLHLWTDFAKHGFAPFIPSLDTPFWPPYTIQRPTTYLIEEKLLPVDSYHDSATHFWIRYLPSISSSSITSASIIDRTKSNSKWHQSKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1Z3</accession>
    <name>A0A922L1Z3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Leucine rich repeat C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">kek2_1</name>
        <name evidence="10" type="ORF">DERF_011785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1Z3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000082">
        <property type="entry name" value="Leucine-rich repeat-containing 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF12">
        <property type="entry name" value="KEKKON 5, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037080798" evidence="8">
        <location>
            <begin position="28"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="270"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="905"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="907"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="948"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9507082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="961" mass="105962" checksum="FD51FDFE963E3596" modified="2023-02-22" version="1">MKSLLMWPSIQLIIVLIIIIIIEIVESQLMTCPQVCSCIWRNGKQTTICENQNLISIPNQISPSTQVLDLNQNNFQILPSKAFQERGLINLQKLFIPKCKLGAIADDAFYQLTNLVELDLSDNLLTHVPVKALANATNLRRLLLNNNHIATITSESFAALNSLKFLNLSGCKTHTIEARAFYGLRDLEYLYLHDNQLTTLPYAVVADLPALYSFELYRNPWQCNCEMRPTREWMIRNNVGQSIPATCDLPIRLSGLMWNSLDLDDFACEPDIITTTVEVAKVVGSNATLSCTVKGIPEPKVFWYMDHGYYNISSQRSHKYHLSEERTEGTVNSLLTIIGLDMNDDGTSFICSAENRAGIKSKNFTVYVVPSGTFGVPSNWSKVELAGGVLGLLITLVLAFVVITLILIRSKRFSFYGNSTKSDNNGGSGNNDSLEKKNSLNKIFGQNGAAIYPSSINGTLSTTTYTNGTTMQQHALSMLGLDGIDKKPEIFLKPDLLVPGNFMDNTKSNSQIMIMPTTTSQTTATGYELNHFGFNNNNNNNNNIGQQPGHHLTFSNDVLNGGGASHQDTLFVTQDSGYMTNPDHHHQQQQQQMSGLYRAVMVNPTTVITNGGSGCGSTATMTLSSSTTTTTAPQTNSSTMTYNTSATSPMNGNIFNGGNNSSTPPSFMLSSAPNLLYTNQYLSQFDLNNQQQQQQQNHHRLATPPNHQFFTHHPHPHPQQQQFISNTNNRQISSNPSPSPLLISTSYGNPAFISDSAASINGFVCMDDNNGNGTTTTTMMYNDINGDDDEVFRTNIINPSISILEPLPLQFQQLPRQSTTLLTSTSRPNLLTMEESLYGIRHTPINPIQQQQQQPSSSSSSFITMAPMQMAPPAPNHHQQQQQSIYGVTTVGKSRWQTMTPNYPFRQQQQQQPQLSSQMTATTSLSNIRYSPDEGYGEESSTGGSAGVQHSTVGQLQGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L235</accession>
    <name>A0A922L235_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L235"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9512079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="151" mass="16697" checksum="C3744D25FCFF8C4C" modified="2023-02-22" version="1">MEDASVRKLLIPDGGPETNRAELESSPLTGSSIQIRLGIRTDVSSIARASRFLSPPEQFCTIVLAVLAMSNSLRRLKHKPNFVCSSNQVSGDLTLLASSNWYETTEIELCRTGQFGFHFAIENLQQRRFARTGAAHDCIQCSKLKLSTEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2I6</accession>
    <name>A0A922L2I6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CAAX prenyl protease 2</fullName>
            <ecNumber evidence="11">3.4.26.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Farnesylated proteins-converting enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RCE1</name>
        <name evidence="16" type="ORF">DERF_013651</name>
        <name evidence="15" type="ORF">HUG17_1000</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="11"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2I6"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="14">
        <location>
            <begin position="169"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7645462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9497685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="313" mass="36757" checksum="6CD305298D983B00" modified="2023-02-22" version="1">MMSSLLESNIIDNDENYETTTTWKQQSISLLFTIFLSILYPASLYVWRDSARIDRNDPMIIKRNFFSVTIISLISLQLLNLFRQFTRTLPPDSPLMADSTIIINYFIYKHYPNNWNLIADCVIKPMMFIMILFIGPIFCDLNLNNIRNYKIIMNRTSIYNMIQSSYNLSILKILRNLIVAPFTEEFLFRGILIAILSPFWSKLSCILISSTLFALMHTHSCLVRYFINDKYDSDDIIATIIQCIYTGFFGIIAAVHYLSYGHLVTPILLHFFCNLNGLPDFPRILENRFYFHLTIVGFTIWFYYFINLFITLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2K3</accession>
    <name>A0A922L2K3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_009454</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2K3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000800">
        <property type="entry name" value="ATP-binding cassette sub-family D member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="536"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="798"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9510966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="820" mass="93897" checksum="91F14312EDBD24DE" modified="2023-02-22" version="1">MTTVMSKLRDLSDRIGVPYPHITRTISVIHNNGKIDQSISIDTSATSIEILSSSSDDDDVDDVDVDKKKFPNNHHHHHHHNDHLVRLVSPIKPGESSQERFLNFGPQRTSKIMNKLEKLFVQLMIEIRHLTGINVDFVIQLIKLIRIMIPKIASFEVIILIMHTTSLISRTFLSIYVANLEGRVVKHIVKRDLQQFTASMTKWLLISVPATFLNSLIRYLESKLALAFRSRLVSYACGLYFNNETYYAVSNLDGRLENADHSLTDDITVFAQHCAHMYSHVTKPLLDVAVVLLTLFRMGRQMGSNGMHGPIMGTSIVFCTHLILRRCSPQFGKLVSEEAQRKGYLRFIHSRIISNAEEIAFYRGGHVERTVLDRAYRSLTRQMNLIFHKRLWYVMLEQLLMKYLWSATGMVVIATPIMLTGIKAIDNKRNKQHNDQSEDISNRTEYMMTAKNILISGSDAMERLLSSYKELTELVGYTNRVAKMFTVFEEVGRGHFKRDSHANKSISMTNEKAMIMYDKSGSPLIRGEVIIVHDYIELINVPIITPNCDIVVPSLTIKITAQMHLLITGPNGCGKSSLFRIMAGLWPVFSGRLERPQSREMFYIPQRPYMSLGTLREQLIYPDTIKIMNNKGIRDEDLESILDQVHLRYIVTREGGWNAKGDWKDILSGGEKQRMGMGRLFYHRPKFALLDECTSAVSIDVEAQMYETAKQLGITLITITHRPSLWKFHTHLLQFDGQGGWHLQSFDQNNDYRLSLHEEKESLERSSLSNVVQKQSRLQELCPLSGESVDVVLVSDHHHNNHKHNNSNDDLNKSNMSNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2K9</accession>
    <name>A0A922L2K9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="3">2.7.1.150</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">DERF_013719</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000510">
        <property type="entry name" value="Phosphatidylinositol 3,5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="17">
        <location>
            <begin position="57"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="18">
        <location>
            <begin position="1629"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1424"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1491"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1873"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1424"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1888"/>
            <end position="1912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9497760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2082" mass="240745" checksum="A35138A9EA1FE0CB" modified="2023-02-22" version="1">MDKSNNETNNLPVENDDLQMKNKRTTTMTTITTTGLIESVRRKFKSKDIGRQFWMPDSTSINCFDCATRFTTIRRRHHCRICGQIFCSNCCNEMIDSRLIDSRDSTSNNNTNSGLLRVCKYCSNRLQNLFTEKSKNNSNASNTDLRDQIHHRRKQSSSSENRKFSTSSIGDIVRFAKANFDNSDSVMIDLKKDHHHHHHHHRHSYQSSTPKNYRPSSAAAAVTSASFDSRFILNDELSISNDNNSLLSCSFDNVQILLDEIDETIDKREPIWVKEIDEEARLKKQANKFSFISEDKQNNNSIVNDQISHDNDDDDDDDVDEIRSSINYRSNDDDNNDKNVNDNHKIIVTDQYDNHHTNDQLDGNDDKPPQSSNQSLFNDTLIYLDRFFDKNPFFTTTNQESKLENDQRNVSIEKIDKTELPILTMNYIYNNHSERILNQILKDEKMSIDWHPILNTMAKQIADTIKLPQFLYLHSIDSYYQLNTDSSIISPSSNEICPYPMDIRKRVKIKSILNGSKNDCTIIQGLVFTKNVAHRKMRTNIDQPRILLFACSIGYDERRRSQPSSSSTSQFKLTLFDSMRLQETDYIANLVAKIELLRPDIIFVQGTVSQTALELLRQKQITVILNVKCSLLERISFFTKAELIHSPEMILNTTIVGGCQKFFLKDYQMSPDTQQQQQQQQTRRRKIYFTNTKTLMFLEGCIENIGYSVILRGSTRFQDFKKLKKILRYMMFVHYNNRLEKAYHQSFNCMPIDERMINNNNNDDDDDGDGCVSLGQYYQMMIRSNNQTIRTNNNNNNNSGHLSQLTIIEDFSDPLRSTVAATVTELDPQENQYNNNSGHNKMTNEPLIQMQLLSKKLAKFLDTIPLSSSPLIRFNLPFLMYENIHHISSLRFYYPFRLLPSKRLFEHDDKSGDVFIDDDDFANYSYLFDGKQSSSNDDDDYGSKNESSKLLFLNSLTSRYMIVKPHPFLINDDYDFNQKSQQYISDFRACGPYLRYAPDFFTLFSLQTETVFNYCLKPKILSINYYGNNDMSLGSFLFLHFFHRQSCFNQSSMINGQTMVVTNNFNHAQEMFENTVLFNNNNNNMATNVGRKIFCPNDNCHISMFKHLMRFTHHNGTITVYLNKLNESRNVEMPHKILTWTYCTQCQSISEYTEMSADSLAISFGKFLELKFFGNQHFNYQKFFDDEDNDADVDAELDGNRKKKNLCRHSLHKESYQFFSYDQLVVIFKYEPIVIYEIVTPAPVIPVTRNHFSKTKMIDDLKQLTEQCHEVFAKIKNELEKIQLMIQNGMTTCSTATTTNTTTTSTSNTLSNNVETMNNLAKLEEFQLMQQKEELDFNRKIKEMHFQLSIPELNQANVLDLFNLENNVAFIKKLIAEIVRSWNDRFRELFQEDSFGGQSKKRNNIDNKFITSFVNRFLSNDLESKSNNDKNHVENENNNVDVSGKDDNLSSYFSDLNEIYDTNSIESSNVDNNQEKSPNKLSLLKNKMLSKVAPKSSSSSLSTTTTTTTQDNPDSSLSSSSFTSKIFNRNIDDMNVIIEMPFDNNNSSSNNKNVNKSNQMFEHYQLPTYKDVSIIVRDRDLGSIISYSLTTPEYEQKLSAIKSEMEAKSNVINESVKVTAETNEKNKMNDSQMTNNASMAMATATTNNKNEQTELNSTSCSNNNKTVAKNASLDQQHKQNQPQEKINQHIDIQFNDVNAKFYCCIYFAELFRKFRSLIMIDGGNSARYTVRDNNHQQHNHSSCSFSEDLYIYSLANCLPWNAIGGKSGSTFLKTRDERFILKEVLKGEVKHFLTFVSDYIDYCERTLLEKLPSTLVKVVGVYQISYKNTLNNKGSIHYILVMENLFYECNHVSYIYDLKGSMRNRKIDVASTYQSNNSNKNQDEDMNTNKMIDTDSSLNSTASNSDQIRSMDNSQTAITKTTTTTNMTTTSTVLLDENLRQITIDRDSEFLKNHCVMDYSLLVGFDEEHNEFVVGIIDYVRLFDWGKILESRVKKIANAIDPTVVHPSAYQKRFVDAINDYFTQVPDKWYPFMKLTPLTGKPFLPDDCKQKNKKQQQQKSNCDINADNVYNQSIMKLKISST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2T4</accession>
    <name>A0A922L2T4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2T4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="7234" checksum="9967AB5939AE0236" modified="2023-02-22" version="1">MADDGTDGNENRIISLQNISRIRYMAENYFRLHNFAQWLQYFLSFHATSMKWLKKWNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2U8</accession>
    <name>A0A922L2U8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DYNC1H1</name>
        <name evidence="18" type="ORF">DERF_013942</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
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    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
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        <property type="entry name" value="AAA_9"/>
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        <property type="entry name" value="AAA_lid_11_sf"/>
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    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
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        <property type="entry name" value="DYNC2H1-like_lid"/>
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        <property type="entry name" value="Dynein_2_N"/>
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        <property type="entry name" value="Dynein_AAA1S"/>
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        <property type="entry name" value="Dynein_AAA5_ext"/>
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        <property type="entry name" value="Dynein_C_barrel"/>
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        <property type="entry name" value="Dynein_HC_stalk"/>
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        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
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    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
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    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
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    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA_9"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1967"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2292"/>
            <end position="2445"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="2674"/>
            <end position="2824"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="3016"/>
            <end position="3182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="983"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3295"/>
            <end position="3364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="3523"/>
            <end position="3620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9498015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="4780" mass="549585" checksum="1B1BCB754BF3D520" modified="2023-02-22" version="1">[encoded data, 4780 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L403</accession>
    <name>A0A922L403_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L403"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="7128" checksum="DA27D2D833B7C027" modified="2023-02-22" version="1">MIHNLLDHCHMNCLTSSNSSRIKFFCCCGRHFSDSYSNNAQILLDMRLFAHTIILRRYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L434</accession>
    <name>A0A922L434_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_009516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L434"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF25">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9511030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="338" mass="37363" checksum="F9AB352E0A4C0B2C" modified="2023-02-22" version="1">MDFFGSNFVVYLETLKFNDAQLAYASTVLISIAPFMVLFLFPMDNTGRYRNRLRLALSFASGGLLGDAFLHLIPHSMSEHHHSDHGHHHDDHTEHHDHDHSHHDHHNEHHSHHHQTKVGLYIIAGIIIFFIIEKFVHLVKGSDHHHHHQQQPQQQLQSQSSSNKKKNKAKPVVESKHSDSLDSSKGRHLVSGILNLIADFLHNFTDGLAIGATFAAGHGPQMGIITAVTILLHEIPHEIGDYAILIQSGYRRRSAILLQLVTAVGALMGTAVGLHYGTLEHATQFILPITAGGFIYIATVSVIPELLETKASSHGQSITEISALLVGVAMMYGIALNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5P6</accession>
    <name>A0A922L5P6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5P6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="304" mass="34071" checksum="435F2CF628F6CC12" modified="2023-02-22" version="1">MGHNKRNITFNNEVIEFEISPLASDNDDDDDDDDWTPTDDHLPMESVESEIEIINTNEDNRVQSMNNSKRMFIIGDDLNLTFRGDQKSSTTFEGEKIFLNNDDDEKQKLQEISSISSSTTSSTTSSEDENEQVIRKTPINEPINNYNQQNIQQVIKVDVHGKSLLVNSNENSPIPVPAKRKNVPQPVTTTTFNHALNSLLDNDNEKIDKSNNEQTRRVSELAELIEKKLQSPARSSLSQNSTKKLPPLGSLSNLKKSSTSSSDNQSIIAPTGNVTSTKSDSSFLNNTNLNSRNNILDAYDLYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L698</accession>
    <name>A0A922L698_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L698"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7723" checksum="256BA26981587649" modified="2023-02-22" version="1">MVLSLVIHCRKKTKEFVYGNATKKTKIKLISQIFISSNVHCSSLTCTYLNIMTLNGTKLICCYTTYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6B5</accession>
    <name>A0A922L6B5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6B5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036942543" evidence="2">
        <location>
            <begin position="21"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="302" mass="35512" checksum="793371966D731F88" modified="2023-02-22" version="1">MDNRFVLILWLFSISFVINSFPSPSPSSSSILYLEQLYENFVDENFHRMNINHNFSEKIANLIRNFYQNNDHQHDLRILMKTKNIAWLETTISTIIISTMANNSIIMDKCRQNNNQIKSSIMNTDLELICAIKHIHETKLNLLYWLLIDFNDIILTFYDRIIIDCKNWTICHSDDQIIRNEACRLLNYIQINSNCNQQLLIKMIQIEIQKRFPTRWHNKLLQVLNTGGISALQYVLRQLCRIDVHLTSLLSGEIVSIIRENQKSSSSSSSFNGQMERRQNYIILNVLTFYLATVEQYLLLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6D7</accession>
    <name>A0A922L6D7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_010019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6D7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037875812" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="795"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1238" mass="138614" checksum="10FE0146BDBD685C" modified="2023-02-22" version="1">MAAKNYLKFLLFSTLLCFTQQQHQQQQNQLKIDPFIKRILTTTANGDNSGGSRFDLMIEPHVSNVEMLHSPSPSLSSSQQQQQQQQQQESSDNLDEQNSTMTNNNVFQPLSSSSSTWSQNFNDNQINTNSSLITANISATPISTDSFSHWNPSPIINTKPLTFTRYALFDSFYDQPSSSTNNHSLIRRRRIWSDTTLESDESDNDLQMMKILPSPPSPSSSSSSISLATPPTNNHFSLMIKSPQSSLSTSTTSYPKETIFDDDDHENDDDDSRDDMNLDYDIDDMTRVTNEDNSGPNNSDEINENDDSNGEDGQQQQQQRQQKHHHRPSSIRIMATRNGSLFGMVNAANDENSINNGDGDLLNSSGSTSNQNFIIPDQIMPYLNAYSTHLNSEIGKSSSPSMANVKPINGNNDDVFIVHHQHHYPPMFMNSESVTGSSSMTSGSMIQPNHHHANVLSPATQTPFRPMKNRHKVNRKKSKKLQIVYIKVPLLNLMDGSTTTTTTTTKSDAASSTKHSSMEIDDIDDGNNNNNSGSQEDLNEMAILTSMKNMAKTTTTTTTTTTTPRPESSNKREHSTSLSSIQKTIIDEEPIDIDLNQQTRNENGGGGGGNNKQQPPTSANLMDLNDRFYYFMMNKMKNFTTSNNNNGGAGDETIMMNTTVAVDDENDNYLMIKSKSKPTTTTTTVEQQHYQSEAIPVSKHHYEIYHNNNNNEKDSLLLNERDNINTNSIYMDTGFGDKDANASTTYQSSLEPLLYHYTPGSNNSWPPEKSLGILPILIQIEDKKSDNEIIDGTSNNNNNNNNGQQQQQQNSVDYRNNNNMMMMTMQERLYGQPMNIINNQNNDWSQRENGNGVGAVNHNNQWPVINNKQQQQPPQHPARNVIFHNNKPTSLAINPSASNLYPDYHHHHHYNNNNPNLHTNNNRLRFSPFGPSSYIDDEQNLMNMIGNNGVHPIATTTAANNKFLNPIYPSASDAHLNYYGATNTNPNTNFNYRLLEYWLLRNQLSKTPSSINANINHMNRMKINQDLLAAMQTKLFAPKTTTSSAATTTLPIELEQIYFSQNNYPGYTYGDFMKMPDKYKDAILRSKLLAPLTATATTTSSMINPLDVSTKDLATLASFIWQQQHQQQQQQQTTTGNNKESNKNNKNGNNNNLNNKKRTRSSLKTALAKQFSLSGLTSSNDGGSGTIINTGNNNDKRMIKDDSSSTITTDNNNNNGNGSLMDKRKKSRRNLTKFGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6M5</accession>
    <name>A0A922L6M5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Calpain-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CAPN15_3</name>
        <name evidence="16" type="ORF">DERF_010221</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000010">
        <property type="entry name" value="Calpain 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF382">
        <property type="entry name" value="CALPAIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="14">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="14">
        <location>
            <begin position="560"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Calpain catalytic" evidence="15">
        <location>
            <begin position="658"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="735"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="906"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9511793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1294" mass="147514" checksum="D8247AF7B8330561" modified="2023-02-22" version="1">MNESQKNPVSVADIQSKHLPTTISPSKRFRQLKKDHVISNKQNKRTDYRRLFGYSDIHADDNETDCSSLSNDRIINKTLIKCIGKKHTKWTCKNCHFQQNLSTYSECANCGRQKCHTNSHEEFENNNRNRNTAIGSRNHQFDCLDKRSHGHANVPVINHNKKWRILFRLLSDDLNLPSSSTGTNPLSNFASILVDMAKSTTTANNNGTNNGKRHSDTSSSHRHIDQNDGNKPEYYYSQTDLYTYLNTTLGCDGGGIRMIKNRHTDKYRHWKCEICHHPFNINTAFYCYICDQHRFGLKKQSASKQLLRQMVQNSKFWARMNIESTAANDTNEQQQQQQQSDFYYDDSLVSKSSTLCYNINRSQDEDFQNNDSDEYNQNIERLDNDDEDDDEDDEDDDDNYETDSSSTLSSLTISSIISESISANNLYLCIENLKLEESNNRNDNNNIDNRQTWQCIKCTLINGDEQQSCAVCGGSRLNSVESESITTTNNFINSINNDDKPIFVTINPQQQWTCIKCTLRNSIHNDPICAACGYPRPPPSIQNPSLQSSQSQTRRRDLTRRNRSHWECSACTYLNSSDRFSCEICHQGRCVLTLKPVNLSSTNDKLSSEIVTEKSIPQDETLCHGESELMETLRRIEEKESRRLWHNIVQFCSNNRMQFVDDSFPPSDQSLYHIQSTLQSTPSSATINTLRLNTGPVQWLRPHQIQSDISSSQVRWAVFRTPLPSDILQGVLGNCWFLSALAVLAERSELVERVMITREICTQGVYQVRLCKDGQWKTVLVDDLLPCNLKGQLVYSQAKRNQLWIPLIEKAMAKLHGCYEALGSGRSIEGLSTLTGAPCESISLQSPKSGNGQQQLPHNEQIDYDFIWAQLLSSRAAGFLMGASCGGGNMQVNELEYHNVGLRPRHAYSVLDVRDIDSLRLVRLRNPWGHFAWNGDWSDHSSLWTTKLREQLLPHGAAEGVFWIAYSDLLKYFDSIDICKIRNDWNEIRLQGVLPPNAFDIDNIPVVLLTVTEPTEIELNLFQEGHRQSHQQQQDWKRDTSSSVRNAPLDLCVVLFKHNEQHRSDDIASMLMGSLVAHSKRQIRCFVGCHAILEKGVYTVMCLAFNHWNTKIVSFSHYPKFLLAIHSSKRLSVETITGPPFVLADTIIRLTMERGQRHEVLLYDSFISSLFCMFMGREGMTAYYLTKGWAGLVVVVENRFADRCVQVICDCTDSVNVVSTRSTLRTIDSIPPQHRQVVIVLTQLDGSGGFSIAHRLTHRLSYSSGLHDWGPFGTNHVPSIDRFMYGLHAPRPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6U4</accession>
    <name>A0A922L6U4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6U4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="103" mass="11013" checksum="14DBCA4B72DEAB39" modified="2023-02-22" version="1">MLIIVDWIPASTIILFGGARSKFVTMSDVSDNCAFISSPDKPFSIFKPSLFILSGIGILNTSSASTSSTIPTPNCPPKPSSNAGRSKRSILLFFNDIPLSFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L797</accession>
    <name>A0A922L797_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aph1ap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">APH1A_1</name>
        <name evidence="8" type="ORF">DERF_005559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APH-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L797"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028233">
        <property type="entry name" value="BBIP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06105">
        <property type="entry name" value="Aph-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14777">
        <property type="entry name" value="BBIP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9521948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="314" mass="34925" checksum="DB8C7532AC215F43" modified="2023-02-22" version="1">MAYLEFFGYCLIAFGPSLAMFCLVIANDPIRIIIMISACFFWLVSLLLSSILWTIVVPLKEYLLFGVTFSILFQETFRYLFYQVLRKAETGLQKVAEVGRNGSNEIQPKLDTNRMQLSFVSGVGFGVMSGVFSLINILADATGPGTVGLDGGSTYFFLCASLTTLAFILLHICWTIILFKSCDSGNKPFILFVLISHLAASYITFLNPSKLYAISIPMQYLLLVITFLVTLKCADFRFDQFSSSASSIGGGGGISSHTEIKPIIPSQHLVIIDERPYFVLCKPKLLPLKSIALLQVESIQREAEEKIKLMQQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7G4</accession>
    <name>A0A922L7G4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7G4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037709762" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8716" checksum="FDE9733CEA1D1DA7" modified="2023-02-22" version="1">MKNKLFLFIIITIWSNGGHFGRLYTCTEQQSPSKVTHEPVLKNSNKLAIQQVVNSNSEFTELTCANDYHMYREIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7L5</accession>
    <name>A0A922L7L5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7L5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
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            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
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            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="141" mass="16037" checksum="C98B1279B91A2155" modified="2023-02-22" version="1">MDMNESGRRFSLRIRAKKLKHDKNEPAKRSRVDNFKQKNETDNQQNVTGDKNEITSQVGPLKPNDGFDDVIYLSDSDTSQDKEDSESAVDPDRSENDNATKEKQAKTNDQNDSETDVESSVIYISDDDDDDNHDSDDKFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7U6</accession>
    <name>A0A922L7U6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000593</name>
        <name evidence="2" type="ORF">HUG17_8367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7U6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038277027" evidence="1">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7640898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="278" mass="31762" checksum="2D2E54F86278726A" modified="2023-02-22" version="1">MKSSAIISILILLIINKTIESASVHRRNGGGGGGGGGIKNNSTMKPFRWILDKPQCLERQRMAQVDLYIERMIGFGRRGRPFPENGAQLKPYCNETRVMVKYIDEYLHECYERDIQKLANIVLYTLKRNIRYFCNKKPTNKKLKNLLKLAGCLNTRIKDDDCIVGMMNSTSALIPSGISSKEKIKYVCCYYAELVRCGDEWMDTIPCIHNDKEIALDFLRGLSSDIISVACSDYNEFTNRCDHLKPLELKQHQLAKRKKYGSILNIMIDTIESMDGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7W0</accession>
    <name>A0A922L7W0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Postsynaptic membrane assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Ces3_2</name>
        <name evidence="7" type="ORF">DERF_000632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7W0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="446"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="407"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9526556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="579" mass="66470" checksum="A5B0D2A4968F6A15" modified="2023-02-22" version="1">MKTKKKRQRQRKRRITESQRNNKMTTTTTTTAKISICQCQKIMENNNHHHHYNHGLLCHLIDNSNDNDHQQNPDNSTILYNTSIQSIFGSRYFQKQQQRQRQQQLFILPSSSSSSSSTATSISDHCFRFLSTTIIYFHHSLFIDLNISDQKRRKSFIHQPLLRQIQRKMWIRQQYLLLLSSLFLSVFCFGFVFSSITSPSSFTFSSIQNSNQSDNLSYSLPMNQSSSSSTTATTTTTISTTTVISNDNLFNSSKYLINKENFDWSSSPSSNHDHHHHLLIKTSKRSNPIDDFINIDEDDNDNTDDDNDDDDIMFIIDDSDVDAVPDTIDDPPPPNQPIRRQKKSSSPSPSSSSEEEEDFNISGKQQQQQHSFVNDNVDYVMHSPRTVQTKYGALQGIVITFVRYNDDDDDKSSTSTSTSSNQNHNNSSSTSSIPPPPPQPIITLSPVEAFLGVPYATPPSGNLRFMPPVAPIHWRGVRQANHLSPVCPQSLPSFTTMMNLSTTTNDHQKQLHLSPKHFDRLQRQIPFLRNQSEDCLYLNIYVPFEHYYQHRLYQRQRQQQQNRKLKSTTSPTSSFEILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L842</accession>
    <name>A0A922L842_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L842"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="96" mass="10989" checksum="0B21E6841691BB8D" modified="2023-02-22" version="1">MDSKLHHHHHLVYSYYQLSATAVHHHFPSNCLFLSAMANSHHHHHGTANSCYQLSATAYTVPFKSIVNCSHPLGNETTWYRPDALLKIMLLSRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8R6</accession>
    <name>A0A922L8R6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kelch-like protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">KLHL18</name>
        <name evidence="6" type="ORF">DERF_005511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8R6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF497">
        <property type="entry name" value="KELCH-LIKE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="235"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9521892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="779" mass="87520" checksum="01E6D958254103FD" modified="2023-02-22" version="1">MSFLCTSSSTDQSSSSSSTSLNPNCNHQQLDPVNFHSTTSSLATSPVIESCLIVGGYHHMSGDNQSCLSLSNDEKVHNNHNNNNYDDNNNDIIITATTSSLLMEDENDYDDDESMGILSKKHPNLVHRRLTDPEHSSIIKMSDDNNHPRSWTVKLQKMHSSDMDNNLKSPTPTSHNKDKMNKTTTNVKQPETMEKVTNNNNKCIVNADNFTYVSMEHANSSFPVFRELWQRRQVCDVIIKIDGHRFVAHRIVLCATIPYFYAMFTNDLAERNQMEIEIKSNDDGDDGLSLDGEAFESLLNYAYAGTIAINSKNVQSILIGASFLGLENVQQACSDYLKIRLNVGNVLQIKTFAFALGCHTLVQASKRYIHRNFEQIAQSDDFLQLDSAEMIDIISSDELNVSNEKIVFEAVMRWTSHDEKMRQQNLADLMRQVRLPLLYPEYLTDVVLGNKLVRQSLECRDLIDEAKDFHLLPARRESIARERTRPRSGHHVQGSIYAVGGLTKTGDSMSTVEVYDPQTKRWRMAEAMSMMRSRVGVAVMERKLYAIGGYNGFDRLNTVEVYDSKVKQWKRVKSMHYRRSAVGAAALSDELYVCGGYDGSISLNVVERYSSTTNEWTEVTPMNIKRSAAGVVSLDGYIYALGGHDGLMIFNSVERYDPRTKQWEFVESMLSRRCRVGCCCFGGKIYVCGGYDGCTFLQTAEVFDPQTGKWSQISKMRATRSRVALVANCSRLFAIGGYDGVSNLSSVEAYDIEKDSWEMVASMVAHEGGVGVGVIPDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8U5</accession>
    <name>A0A922L8U5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8U5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="286" mass="32306" checksum="36069394681723CB" modified="2023-02-22" version="1">MNNCPLRSPSRKRLVSILQKHEKFELAISGGAIADLMFRFLKSSFNTFNIPSYILKAIIRALAFTSQSVPFSDGRSDFSVIIPWALVLTSKSPCFGSRLNSRIIKLFLSVMINKRSLSSLGIRKDFMTDIRPLRGISFNDRKPSAVTRIKFKSVGDVKFPELNLAIVLIQAKNSKNRLPEMALKTAVDFCAVTTQKDFCENLLRNKNFQINNDDDIKPRDNFFSEQLGLKRTTIVAKSNKLRSFRQFSGTAKMKCLISSLNSESDNCVLQVLNCSNVPFSLFYSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9B5</accession>
    <name>A0A922L9B5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Med26 domain containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Transcription factor iws1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IWS1</name>
        <name evidence="14" type="ORF">DERF_001109</name>
        <name evidence="13" type="ORF">HUG17_4345</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9B5"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000001">
        <property type="entry name" value="IWS1, SUPT6H interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="12">
        <location>
            <begin position="210"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="299"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7641301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9527063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="411" mass="47615" checksum="ECEE3219BF15728C" modified="2023-02-22" version="1">MSETETIVRDIFGDSDESDDEFEGFDGDVGGEKSQDKQQQQQQQQQSEQKDDDDDDQKNDDKEFGSDGSSDGEVFENRPSEELDEEKVEDPEQNAKEAIPEISDSDEGSDDDDVNRNVKSDIMYDFDIMLQKRKEMNSRRRRRKNIDIINDSDDIIAELIQEMKQAADEDFELNRNRQTATRKLKMMPLVETQLKKIDFREALLDSGVLSVITDWLTRLPDGSLPHLQIREKLLRILVEFNIDDIDRIKASGIGKAVMYLYKHPKETKENKRIAGQLIAHWSRPIFNLDADFHSISRDQREKRDFENMAKFKRSQSDSGEGGSSSKMAKTEQKIIRPGEKGWVPRARVPMPSMKDYVIRPKSTVEVDMSRISSKKPITKFEKHLRNFREMKKINKMNRAMPISIEGRKMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA49</accession>
    <name>A0A922LA49_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA49"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1199"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="456"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="614"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="855"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="915"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1259" mass="145148" checksum="F70BF7FAE1E34B57" modified="2023-02-22" version="1">MSDLSFLGLPVSGSQDSNQDNHHQNDLNHTTSYLINFNANSSSISNPIDSNITEYLPAKNLMDFSFKLVNMSTDSKDESNDQDNEKNQVVGELIDNLIEHVESNESINYADECNEIDNEHLDSKKGEHENSSESIDTRIEMNQELNDNPGTQNQSSFDDFFNKFMDPEHDISLFSGPLDGMNESQSEQSFPQQPYKYISVELDDVKTTFTIPFTFSLDKIISTSRMNFQNSDETLPMMNDVNKTPKKQLLNESCKNDEKSVDLKNDTEIGKPDDDEMTHEFDNQNNDENTSAINDFSNTSFEMNKGNGILSESVYRYMTSLMRTPPPDIVIISKDEMGQIQSSIEENAASSEVGTDSFVDAQEELLDQTLTDHCEDEDHDEKDFELVSTPTSKSPDHTISNNRLSLNIDQLNVSPCCTLSNNGTVTKSPSLLAQISADDQECSFSYEDRLELLETKITYEKKIVELYERLDQQKEAISEQVSKVHIEQIDHIRKEYDVQCQKSRDEVDNLRAQQQILHDKLELQKTRYKTVVGELEETMEQLRMDNSSMKNQYETTAFIQINDLKQHRHDLRETIQSLNSNIIELNHRLVESVHDREILTVRLNETLAQKSTFENEFQSKLTEAKQKINSLELIANESESKMESLVSDHLEELNKLKLENDETITKLQNEINNLNSTLESNLFNLKNLNDEFVQKNNELEKNLQEMSKQNKKILEIETSLKLIQCENEKLKLNDQKIVQFETKIHDLETKLSKLKNENDSLKQDVQVSLTREQNHKVKLANSKSEISKLMAVNQELLDAKIELEEARSNIESRLFDCEERNILLETKLEQVEQSEVIHRDLQKLYDDFQAKHAQCDQIGDENQRLHNEMEQLRKQNKELFEKFEQSRHEWTESRTKLLDNNDRLLQSNDTMAGKIVELNDMVQNLTKKNASLDSELKSGHEQLKRKFDETCQRLVETERAKFELETKISTIMAKHEKMADEFKKAEKQFSEERSLLEQKLLVLQKHLRVDKDEKESLDKELLSSEKNLQTAQLNLEQMQVKLAECNDEFVRCQNELGQQREHVLRQQEQINVLNEECKTLKKSNFETERSLDQACEQLGVTLKEFKQVSHKYKISKCLIPALQSKIDHHKEGGEKLISDITSMMAKIDSNKKDSIKNEKVKAILKNITDRLSYLTKEKILVIDSEQTPVINADEARVAEVKHQMPPPSSSLSSSQSTSKSARAFKPIELTSADDQQISDGVRRTMVPKSLNVTNKENIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAA5</accession>
    <name>A0A922LAA5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol polyphosphate 5-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">INPP5E</name>
        <name evidence="3" type="ORF">DERF_004608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAA5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053321">
        <property type="entry name" value="IPP-5-Phosphatase_Type_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47039">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47039:SF1">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="179"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="849" mass="95406" checksum="C658BE0933D108AF" modified="2023-02-22" version="1">MEKTATNSSSSSSSSSLDDISSSSNSSNQTIFSNHNNDQQQQQQKQCSNNCINNDNQPIDISGRLINGHNNDDDDDQLLQPESLANITTTTTKTKCLSPKTAKKSSTSSSSSSSPSSSSDSSSLSITSSILSMNKQQQKVLPPVTYDQIQRNRFIYHDSNIFCESFFSQNELERFFPDHKIRLSIITWNMGSKPPNDYNQSLQELLHLKPFQPLQYGQLNLPEMFVIGLQETPNSEMIVNSLKVGIQSSLGPNYCLLRWSSVGVLHCSIWIRRELLWSCTTVDMVPVHMRPMAANRIRTKGAITLSFTLFGTSFLFINTHLTAHEINLRSQFIFWFGDLNFRLELPVDIVLDAIRRITNTNNPETKDTYLRKMMRSDQLSNLMNRGIIFNGFEEARWPPPFLPTYKCKINHPITGGLATNDPIDHHINTTIIQSSSLNPSTKTTTSITSTSTSTSSSSSSSSSISMKLSYKLNNGDVDDNSTKKSANSSSSSTKTNDNINGDKIVNNYNYESGRVPSYTDRILYQTKSTNHQQIESNDNNLIKCIYYNSISNIISSDHKPVYGLFEVRLDSGCGQRKRLSQLVDEMYLKRLAEKHNNNNNAKTTDQQQQSEQSSSDLLSDQQQQSITKTNHFRRLVDRHVFKKSKSKLTNNHHMDNLDIMDSGIGGGINESSANSSSSSSSSIIMANNQRQWSDRVGQLNAGAYERKIYMEGMRLRNNLMQSTSMQEIRNNGTMMTLIVNPNNQNENTNRIRVMKNVKKSENGNGDHGGDGSGHHLYKSHSLESNLIIMNGGDVDDNNGENDSKQQRQISPLVRHESSEMNQTIDLVTNSRESISHQQNDRNSKICQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAB3</accession>
    <name>A0A922LAB3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycogen synthase kinase-3 beta</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GSK3B_1</name>
        <name evidence="11" type="ORF">DERF_003177</name>
        <name evidence="10" type="ORF">HUG17_5182</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAB3"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="60"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7642137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9529286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="557" mass="62018" checksum="637EF51751363906" modified="2023-02-22" version="1">MDANMNEDNQDTNTSRMMKFDPAVLVVSHIRTITRNGVEIKTVQASVGKKNQYYTKDISYTNEKMIGNGSFGVVYQATLLEENEVVAIKRVLQDRRFKNRELSIMVSLDHCNIVKLKYFFYTHKNQQKEDIYLNLVLEFIPDTVSKVARYYMRQGTKIPMNMIKLYMYQLFRALAYIHSLGICHRDIKPQNLLVNPMNGVLKLCDFGSAKHLVRGEMNVSYICSRYYRAPELIFGATDYTTKIDIWSAGCVFAELLLGYPIFSGESGVDQLVEIIKILGTPSKDQIRRMNRNYTEFKFPKITPNPWDRVFGARTPPEVIDLISKLLDYTPFLRLDPLKCCTHRFFDELRIPNYRLPQDREPPPLFNFTEQELKIAPELNSILIPQHLHSQFSEYIIDNTNNRDLIDSTTNDPTPSTSSSAVATVGCGSEAVSNASQSSELKASTSSVGSSNGGTGGGVVGNVPQQSHMAASPSSSVSSNPRFSLSSPKQQQQTSSEASLKTALNDPNESTVSSSTNNVQSVSGDNNAGKLTDISNDPVTTTTAATATAPAATVKIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAL7</accession>
    <name>A0A922LAL7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAL7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="84" mass="9316" checksum="237EF7F2B449A4E9" modified="2023-02-22" version="1">MAVRICGQIAAVDELLLYSYSYCLPMKNSKRVNTNLLPSAFRLKSAAVNDADIRSDPSKLCCTNAERDMTAGIRLSATVELYWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB36</accession>
    <name>A0A922LB36_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-aspartyl dipeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_002952</name>
        <name evidence="5" type="ORF">HUG17_4995</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB36"/>
    <dbReference type="OrthoDB" id="10052168at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03146">
        <property type="entry name" value="GAT1_Peptidase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003642">
        <property type="entry name" value="PRK05282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20842:SF0">
        <property type="entry name" value="ALPHA-ASPARTYL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20842">
        <property type="entry name" value="PROTEASE S51 ALPHA-ASPARTYL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7641950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9529043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="262" mass="29994" checksum="BFAFA76950B3651A" modified="2023-02-22" version="1">MAVQQNARLLLLSNSTMANQPYLQWPKKLIKDFLNVSQVKEILFIPFAGVSIEWDDYSDKVKHALENDFKVKPIHHCSNYEEAVQNAEAIMIGGGNTFHLLYKLYEHNLLDSIKKRVLDPVKPIPYIGWSAGSNVAGPDIGTTNDMPIIWPPSDLALNLVPYNLNPHYNEWQPPNLKAETRIDRLNECIQIKKRTIIAYAEGVGIRVENGQHQIVAPKFHDHSCFIDNKDNRIVKVWTYENDKIQIDEIPLTDSATLNHYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBA1</accession>
    <name>A0A922LBA1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ER membrane protein complex subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EMC7</name>
        <name evidence="12" type="ORF">DERF_003190</name>
        <name evidence="11" type="ORF">HUG17_5196</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBA1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038277034" evidence="9">
        <location>
            <begin position="24"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="10">
        <location>
            <begin position="61"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7642151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9529299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="237" mass="27250" checksum="648A5F0DB9CD501A" modified="2023-02-22" version="1">MGLQKLLTNFICFLITFIYSVSGQSFDNSQEFANPSSLNELYKIEGKVYNVDGSGPSEQFLVGTKVIVNYGQYYGFLKSDGSFEITNIPPGSYVVEVSNADYFYDSIRVDVNSRGKIRARKTNYIQTTEVIQLLYPLKFKSKAPFKYFQIRESWKITDFIFNPMVLMMVLPLLFIMIAPKIINPQDLETQRELQNLQGSELPEISEVMANMFGKKPLSQQQQQQQQLKIGNKQKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBP5</accession>
    <name>A0A922LBP5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPL38</name>
        <name evidence="7" type="ORF">DERF_003698</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBP5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9529838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7601" checksum="1980766DD30990CD" modified="2023-02-22" version="1">MPKEIKEIKDFLLTARRKDAKSVKIKKNKDNVRCSKYLYTLVINDKEKAEKLKQSLPPGLQVKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LD02</accession>
    <name>A0A922LD02_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LD02"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="8406" checksum="A5ED28DD59E0B5C4" modified="2023-02-22" version="1">MEYENKALFIVGIPYANISIIMVFDNSTTTTTIDETFVQKKILCYVFTLSIHMHTQSIVLLVLEMKSYGCHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LD92</accession>
    <name>A0A922LD92_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LD92"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="145" mass="17374" checksum="DC6421345F734441" modified="2023-02-22" version="1">MLKIPKIIITNVDEDPSIKKELKRKKLFELCAIIGIIVINWIMVISKSCFIFGVLSGIITTLITIIQYILFIKTHFAVHFGAKRPTDETMIEHGHHHHHHNYENPSIFSLRWILSRIAKWRNFFYQIQQRRRWKQQQQQQRQTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDE6</accession>
    <name>A0A922LDE6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002803</name>
        <name evidence="2" type="ORF">HUG17_4912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDE6"/>
    <dbReference type="OrthoDB" id="10290484at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038277054" evidence="1">
        <location>
            <begin position="31"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="126" mass="14341" checksum="025A420489E1B9B3" modified="2023-02-22" version="1">MKGIIKSNKMTIAVSSLLLFLLLIPSSTLAFNLPFDLAMPDLHKLYKPLIDYNTHGAFKFLRCMGPNFAHQCSKPILNCLHHNEPINCIEHLECCQNNKATITCIHYLKSSTIYDKLFHVPIVNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDG2</accession>
    <name>A0A922LDG2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_003037</name>
        <name evidence="3" type="ORF">HUG17_5058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDG2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7642013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9529135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="279" mass="30445" checksum="B87E1A2417147C1F" modified="2023-02-22" version="1">MSSSKISVFGQLPQLQTTSAAPIMINITTEMPVRNETGNYTSLPPITSSELNITTDIFNRTEITNHTIKPTDESFNVTTENGTTHFPSHVTTQFPSHVTTHSPTNQTDDKKIRRAGIIISAVVIAISMATIVLAAFYWLYFDKQEDDQQSMSSRQTAAGLGNNLNQEIKDAAITSLQQQQEQQKGPPLAGTTSDGEKSKSSSKSSSKRAQQQQPMPKESSSSSSRKRKEGQAMMESKDNRPEKSTSGVAASMMDPSQTQSQMPYSDVLSAQSATSKNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q8MVU3</accession>
    <name>Q8MVU3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Der f 16 allergen</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2 4">Gelsolin-like allergen Der F 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_012229</name>
        <name evidence="4" type="ORF">HUG17_9003</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2002" name="FEBS Lett." volume="516" first="234" last="238">
            <title>Der f 16: a novel gelsolin-related molecule identified as an allergen from the house dust mite, Dermatophagoides farinae.</title>
            <authorList>
                <person name="Kawamoto S."/>
                <person name="Suzuki T."/>
                <person name="Aki T."/>
                <person name="Katsutani T."/>
                <person name="Tsuboi S."/>
                <person name="Shigeta S."/>
                <person name="Ono K."/>
            </authorList>
            <dbReference type="PubMed" id="11959139"/>
            <dbReference type="DOI" id="10.1016/S0014-5793(02)02540-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2014-06" db="EMBL/GenBank/DDBJ databases">
            <title>Cloning, expression, purification and immunological activity of genes from Dermatophagoides farinae.</title>
            <authorList>
                <person name="Wu Y.-L."/>
                <person name="Wang Y.-M."/>
                <person name="Liu Z.-G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="5">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="6">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="AF465625">
        <property type="protein sequence ID" value="AAM64112.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM010003">
        <property type="protein sequence ID" value="AIO08859.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8MVU3"/>
    <dbReference type="SMR" id="Q8MVU3"/>
    <dbReference type="Allergome" id="299">
        <property type="allergen name" value="Der f 16"/>
    </dbReference>
    <dbReference type="Allergome" id="3252">
        <property type="allergen name" value="Der f 16.0101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11292">
        <property type="entry name" value="gelsolin_S3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF57">
        <property type="entry name" value="VILLIN-LIKE PROTEIN QUAIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="164"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="297"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="1">
        <location>
            <begin position="404"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAM64112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AIO08859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7637899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9501378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="480" mass="55132" checksum="F45007DA980C47AE" modified="2002-10-01" version="1">MAAHDKNFDVIPIGHTFFFIWRIKQFELVPVPKEDYGKFYKGDCYIVACCTENPTGGHSKMESKPILNGHGYCHIHFWIGSESTKDEAGVAAIKSVELDDFLGGYPVQHREIEEFESRQFSSYFKNGIIYLKGGYESGFTKMIDELKPSLLHVKGKKRPIVYECAEISWKVMNNGDVFILLVPNFVFVWTGKHSNRMERTTAIRVANDLKSELNRFKLSSVILEDGKEVEQTSGAEYDAFNKALSLDKKDIDLKQMPKGYDYAASDKSFESHERSFVTLYKCFEGTETIDISFVKNGPLSRADLDTNDTFIVENGSEGLWVWVGKKATQKERQSAIKYAMELINKKKYPNNTPVTKVLEGDESVEFKSLFESWQMSEQEKITSARLFRVSRNGIFKQVANYEPDDLEEDNIMILDVMDKIYVWIGNQFAERIADEAHVDKVAQRFIQEDKSGRKFQPNQIIKLKQGSEDGAFKSYFPKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HGJ3</accession>
    <name>A0A922HGJ3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HGJ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="144" mass="16360" checksum="89B52E0BC4096CF4" modified="2023-02-22" version="1">MSSSSTTTMATTTNVSPLLCKRIRKFLIDYQCEIRYRKMNPPSSAMKSNTYDSSSSSSRIFSSLMAADPTTANALQTSTVVLRKKNKNKKNSSFDGIPISNYRIHSNNLYAEIFDWIYHFLWLKPLKLSSIIVSFTPNWLASIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HGK9</accession>
    <name>A0A922HGK9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription elongation factor SPT6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SUPT6H_1</name>
        <name evidence="8" type="ORF">DERF_014092</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SPT6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000002">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000030">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="1280"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="501"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1695"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1702"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1715"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1756"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1766"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1798"/>
            <end position="1821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9493338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1837" mass="211711" checksum="F0C01AAC83FD1F2B" modified="2023-02-22" version="1">MADFFDREAVSSEGSEDEEVREDIRRHKKLKTHKKTRVGSDEDSEEEEEDDDEIIAREMKDLINDDVEEEEDDDDVDSEDDIGRGHKRSHDDDDLEEDLEDDDYDLLEENLGRRIERKKKFRRVRRLEDDDEDDEEDRGDTLNAREAIANELFDDDDGFGNADQQQLNRAQNRGIREPSDDQFAPIDSEHSESDEDNFIVDDNDQPIVAKQRSKRGVGYNDQALQQAQDIFGVDFDFDVFDDNAEFDEEEMEEDYDEEGLEDRARETGKKKRQRLPKKSIFDLYEPAELERSHLTEADNEIRNTDAPERFQTRSFPVTAAELNEIRDESEWIYRNLYEMPTITKQDKSHGIRQPLAGAKPRSTINVISQVLKYIRNEKLSIPFLAYYRKEYYAPDLSINDLWLIFNWDEKWCQLNERKRNLLKLLENMKDYQLSLMMKNTEDDQPLPDDFRRITDKDLQRAKSIQSFEEFNDCYIQFQLYYSHELTDMKKFLLQQKRSARERKRLQRAQERQQQQQQQQQQRNTENGESVNNETNDMNNATTEELSDEDEKVEELMLAERMTFMRLSMKKDSYSFCRDSGAGRMASRFGLTPEQFGEHISEGYHKHEIEQHPVDPLEAAQEHISKRFDTADKVLQAATFMVGKQLSCDPLVRKTVRQMFYERATITVRPTKKGKKEIDESHSCYALKYLRNKPISSFAGDQFLQLYAAKNDGLVDMIITLDDNTQKHSSSMSTASTSMMANDLATNKQAFSQYLEEIKYLYQRDEFSKNVQDWNDQRSKALDIALNRFLYPFLLKELTTKILSEAQHTIIQHCGDKLASYLAIGPYVPAFIQEDKDHDESYDNDFDTRNGIRIMGFAHVPNNEEASFCALIDGDGEVTDYIKLEHFMLKRVEGGSFSYKDREKLQNFIVSKKPHVIALGTDTIVTKDVMDDLIQMIRHLHDTKHFPLIPIEYVDSELSIVYMNTKRANADFPTYPLKLRQAISLARRLQDPLLEFAQLCSADEEILCLKLHPLQDSVPRETLLNALFAEFVNRVNEVGVDINKCIIHPYTSSLIQFIGGLGPRKGAYLLRTLKKQQTQLLENRSQLIQNCNIGKIVFINCAGFIKIDTNAFADSGTDTYIEVLDSTRVHPEAYEWARKMAVDALDYDEDNDHNPAQALEEIIENPEKLRDLDLDEFAKELHRQQFGLKKQTLYDIRTELTDRYQDKRKPYRPPNDEEIFQLLTGENLTTFHTGRLVQVRVAGIVRRKPKTEQVDQAQPIRMETGLWKCPFCLKDDFNELGEVWNHFDTNQCPGQAFGVRARLDNGLTGIIPLKFLSDKEVSDPQTRVKMGMTINCRILKVIIERFSLELTCRTSDLIDANNRFKPAKDNYYDFDSEDRDIRSEEDSKKRKNRQRTFMKRIIVHPSFHNIDFKKSEQILAESPQGEAVIRPSSKGNDHLTLSWKVHDGIHQNISIREEGKTNAFSLGRQLFIDNESFEDLDEIIARYVQPMAGFARDLINFKYFRDLNGDRHAAEKVLNEEKQKAPSRIPYIVSASKEFPGKFLLSYQPNQKAFHEFITATPDGFKYRNNMFKSINTLFKWFKDHYKDHSTFTRTPGPQTPIINASPYISQRTPQATTSPYVSGSNISSSNKPGFVPTPNINPQAIQRAAQSMPNHLFNTLSQVTGQTSSFNGNFAPTSNVQLAASAAAGGSLPYSAGQTNMMPPPPPLPPVPNTIPVQNNRPGSRGGNQWSDLLKQPSTTDWHSNRNNHHHNNRTMPPPLQPPLLPSSSSTSLQQSSMMISPSSNNIIPLMNKPRTPGYSTPGASSQMSISPMQEDTTATPNIIKGGDQTPLVDEWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HJX3</accession>
    <name>A0A922HJX3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015837</name>
        <name evidence="1" type="ORF">HUG17_3829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HJX3"/>
    <dbReference type="OrthoDB" id="6498862at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7639796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="410" mass="47645" checksum="9EF6F72CF08BB495" modified="2023-02-22" version="1">MKNKILNDFKQVDKTNLEQMTFNLWNNTSIDTSSSASNQFFEVSSTDSVDSAVGVERRKSWHESTQSPLLSQMTISNRLSINDSGQNQSLMPINHPSSSNLVMDDSFMNQMCTLYIDMSFDDRVFFGVHNFFLLKCSLSESQCNVDFSATNNKVSIIGKSENVAKMCKSFFLHSTFALQFEFYFYDEISCAEYMKERFPSLQKEYEKWDVYISYRPDRPNTLLFNFLTFRKFFVRLIQTMINFQMQLEFYQLGRVLPNFMSTLQVPITRRDANVINASYLESIENETGTKIKLIRYHDCQHYPFENVIITGADILSVIQARWLITTRFEYELNFQVFVSDTTMLVKCISSLNYDRSSIEVTISPCVSNPSLDSKILSIKTNEKHIDKIFSIHKELIDSMIINGVISEHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKN3</accession>
    <name>A0A922HKN3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Medium-chain acyl-CoA ligase ACSF2, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ACSF2_2</name>
        <name evidence="11" type="ORF">DERF_015021</name>
        <name evidence="10" type="ORF">HUG17_6359</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33631"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKN3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000008">
        <property type="entry name" value="2,3-dihydroxybenzoate-AMP ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="92"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="533"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7643997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9494329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="627" mass="70528" checksum="47EF21451A18167B" modified="2023-02-22" version="1">MSTKILKLNHLFRCGSGGGGCGGGHHYSKSRLLATPIITASNRNVSTDLLTSETLPPYVNLPYSYAFGRSLNHIIYETIGKRLDDRLKIETGKPIIISHHENIKKTISEFYQDVNRLSKAMYEHLNIKRGDVVGLWSCNTYDWIVIQYACFRIGAILCTVNPFYQSYELDYAIRKGEMKALFMPGHKSRQDIVNRFSTITMKTLEKKADDQNQSTFLLENIITVDGHPFNVSDLPDHHRNIRLFELEKLKQQTGELDSSITNLVLPDDPAVIMFTSGTTGRPKGACLSHFNIVNNVTMCSYRADVKENALFCVPLPFFHAFAGVLGNLIPIASETGGLMIPCLKYDVRQLAQSINEHGATHMMATPTLVIDLLNYLRDNKLQLSTLQEVMAGGASMPIEIAHQLMEFASNCKVRVAYGATETSPCATTFSKKSTIEESIETVGSPLDFVEIKLVDPKTKKIVKIGETGELHCRGHVIMLGYWRDPEKTKESIDEGNWYNTGDLAVMTEKGLIKIIGRTKELIIVGGENVYPREIEEILYTHPAVETVNVIGVPDPRKGEEICAWIQLHKDVKITEDEIREFCKGQLTYFKVPKYILFVDSYPMTPTGKAQKFIMKKMTIEKLNLKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HL60</accession>
    <name>A0A922HL60_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin maturation protease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin aminopeptidase ACTMAP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_014148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal N(alpha)-acetyl-L-cysteinyl-L-aspartyl-[protein] + H2O = N-terminal L-aspartyl-[protein] + N-acetyl-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:74579"/>
            <dbReference type="Rhea" id="RHEA-COMP:12669"/>
            <dbReference type="Rhea" id="RHEA-COMP:18395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64720"/>
            <dbReference type="ChEBI" id="CHEBI:78236"/>
            <dbReference type="ChEBI" id="CHEBI:193599"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:74580"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ACTMAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HL60"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040043">
        <property type="entry name" value="ACTMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28631:SF1">
        <property type="entry name" value="ACTIN MATURATION PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28631">
        <property type="entry name" value="UPF0692 PROTEIN C19ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21646">
        <property type="entry name" value="ACTMAP-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9493397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="270" mass="31515" checksum="DB308B6FA75E4CE5" modified="2023-02-22" version="1">MLLLIRIKLLNLLVKDSFDHFKSFKQNNSPVLLLSLYHHCDPIIQSGPTCGLVALIMCLKLIDNQYDIDLSKILIKAKSYGITRFGEMFSVENMAKFIREEFSLNAEHRYDLERSMYDVIEHLCNGQPILVPYDSDFNHEPGLRQGNRAHWALLCGFCLVDSSSETVNILTKYVEKTVNLETDVLLCPLKSKKFDNIKHLLSMDRLFVYARQGKSKHLHIWNYRKLCESNQNLRRIKSKILNNNRHKQMIYPLDGRLDQSLCNQFIFIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HML1</accession>
    <name>A0A922HML1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HML1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="571" mass="67194" checksum="98F57A303DB549FF" modified="2023-02-22" version="1">MQGYLKIIQDEAEKLREVKGVPRGRSNGDRNRNTKNYSNRNGDDRFKRNDSKYSYRDDDFANKWTSNSSGRGRNDYYNHCDRNNEDSDYKSNNRYRGNDDDDNDRRGKANPYALPPSDSRDNDKIDSDRYSGRENKYSSRQNEDSNCKWTGRSNERNQDYNDDSYGRSDRREKFNPYALPPSDSRDNDKRDSDRYSGRENKYSSRQNEDSNCKWTGRSNERNQDYNDDSYGRSDRKEKFNPYALPPSDSRDNDKRDSDRYSGRENKYSSRQNEDSNCKWTGRSNERNQDYNDDSYGRSDRKEKFNPYALPPSDERDNEDQDTRNDNKYSGPFNDESSLGKSKYSSPSTDCYGNRDDGSRYNSRRDNDEFKKDRREVDRQSMESSRNSYGRDNDEPARNTWKSSQVSVTKDSFRDFDRLLVEFKPPKNLRLQHIILEIESRQIYEKMETILKSSSSKKIVVIIQRTHEFSDLTGKVLSGKGCSVKSLNEQNMDNIEHNEVQAFSTTFEFLADHPNVQLELPDVVINCDLAFKRVKFLERFLVSKSTDKKEVEIYHLGLSNSPFVHTLREIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNC0</accession>
    <name>A0A922HNC0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNC0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="9368" checksum="AA77DD5DC7391348" modified="2023-02-22" version="1">MDNVGISILLLLSISSILIINLNNNISNHNQKKNFFEIETKQLAQYNTIKCKRKLIFFYFINFMTKLSRFSCNKNKNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNF1</accession>
    <name>A0A922HNF1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B9 domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">B9D2_2</name>
        <name evidence="3" type="ORF">DERF_014712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNF1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040354">
        <property type="entry name" value="TCTN1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057724">
        <property type="entry name" value="TCTN1-3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611:SF2">
        <property type="entry name" value="TECTONIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611">
        <property type="entry name" value="TECTONIC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25752">
        <property type="entry name" value="DUF1619_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3 N-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="777" mass="91273" checksum="F8DEA91A1404E0F0" modified="2023-02-22" version="1">MKKLSIEAISKFSISFITIYLILIDGHIPLLFALEPSNIATTSTNLNNITDDQAKLNKNDKQFIRYREEFEKILAKWSNNSKGCECDSILDYCDIDCCCDLNCTEIDRYSFGQCLKFEQSKFISDISEIPSLSMCLDSTNNNNGNQKQLFYQSSPLLCLAKENTFRRQSYVHQPIIIERNQLDRIESKHKFRFGQIVVPMKSIFNDDNDDDDDDVNDDYEQRIIQNITKIQSLVQYKSGSPIIRFRFRTLSNQQQKQKQQKNHTILEYYHWKLPISINSLNNINNRMDVCSGRLEIVKYLKDYQSICLRIVPTNLAEDCTGNQFFDYRTYLQPNVFIYQTFINSEKFNTSSNNSSYKFVRIETDGKHYEQPYYDSETKICHNVVEKVDYLVWHEGIQGIRRIQIWIGQIDLPSISNFSAIYLQSRKFIQQKFNVTFRWFGRKLPTTITKTSLTDDNDENWLQNRPTTKGYKYGQEIKFIRIDQNHTFHRIEKRNFLLGTYAKGLCDHDEKIADSILKFGWNRYEICRLSLNKIMKTMTVNKTDNQQQRQQTTKSVSCTVIKSSVGKYLDFFDYNDDDDNRTNNSSYLFIGSYPPTRLDLIQNDTSIVWIRPLIREINSTTLSMNSNKNNKNSQTNHYKNHLQCTEEIITELMYNFFINRIDQIHYRMIGVEIVRKKSILNYKCTSSNNNVDNDNDDCNLTIDLRTYVNFIDISEPFVPKYAPAPSFRVELPADFFYPFTPSVSSKSSSSIGFQFNHYSSSIIHVFMVMITITIIYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPY3</accession>
    <name>A0A922HPY3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prostaglandin E synthase 3 (Cytosolic)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PTGES3</name>
        <name evidence="4" type="ORF">DERF_013545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPY3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9497568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="211" mass="23522" checksum="B40CE2EA45D44201" modified="2023-02-22" version="1">MTSIPAPLKWAQRKDLVYLNFQVQDVVNPEVVVEKDKIIYRAETKDKQKYESILNLYGEIKPEESKWINRDRGAEFVLIKTESGPYWKRLLKEDTKYHWLKVDFNRWKDEDESDDEAGGGGTNFEDMMRQMGGLGGGMGGMGMPGMGGMGMPGMGGMGMPGMGGMGMPGMGGNFDDLEDDEKDSDDENIPDLEDGDDAKKNGDDNKNSNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQF5</accession>
    <name>A0A922HQF5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQF5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="58" mass="6550" checksum="907CC3A759A9921C" modified="2023-02-22" version="1">MISSKEQCYYKIITICRDMNESQYVVVDGGVGVGGKQCENSLIINFKFLQVDMKNIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQK5</accession>
    <name>A0A922HQK5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQK5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9498025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8404" checksum="14D42A7ED7C43C51" modified="2023-02-22" version="1">MSFLTFQIFRGLGTTSETLYNVFFENITYLYKIYNRTVSIINKITTLANNNNNNVVTYRRCFVAKYHQFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQT2</accession>
    <name>A0A922HQT2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arfaptin-1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Arfaptin-2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ARFIP1</name>
        <name evidence="4" type="ORF">DERF_012788</name>
        <name evidence="3" type="ORF">HUG17_8641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQT2"/>
    <dbReference type="OrthoDB" id="9994780at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF5">
        <property type="entry name" value="ARFAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="2">
        <location>
            <begin position="135"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7637537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9501985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="376" mass="41796" checksum="5CAB0A481DFA90E3" modified="2023-02-22" version="1">MSSSTSTNSGGNNLGRSAETSTTTETYHSSLGQVNITSFDSMQEIAIHDSNSSPGQQSIASARHHHHHHRPATLPLTPPLSGSNDMIQSSAIITAANSCGSNKHTPMDALKEWSMSTYKCTKQLINEKLGKCSRTVDADLEIEIEKLRETQHKYENILKLSRDMSNQYQTIIATQNSMYEHLNELALRETKSPTIMNDDSERSLMNNLSHDFKQNAEMMKSIARNGDKLLMALRFFISNLTTLVYKTIEDTIVTIRAFEAARLEYDAERNCLNGLMCTSHASAGSSGTTTATTTTSTTTNLSSEKMHQVRARYERLKEDVAIKMKFLDENKAKVMHKQLVLFHNAFAAFASGNAAALDSTLKQFSIRPQPSSFLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRB6</accession>
    <name>A0A922HRB6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">inositol-phosphate phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PA2G4_1</name>
        <name evidence="11" type="ORF">DERF_010686</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRB6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000013">
        <property type="entry name" value="DNA-binding protein, 42 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000002">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020552">
        <property type="entry name" value="Inositol_monoPase_Li-sen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004545">
        <property type="entry name" value="PA2G4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00495">
        <property type="entry name" value="crvDNA_42K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00378">
        <property type="entry name" value="LIIMPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="10">
        <location>
            <begin position="34"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9505920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="655" mass="72518" checksum="04512AFB2FA59F83" modified="2023-02-22" version="1">MSESKDKDSSAITGAVGGGDVEKNTIATDIVVTKYKMAGEMVNRVLQQVLDKCVAGASIIDICEFGDNQINEETKKVFKKEKEIKKGIAFPTCVSVNNCVCHYSPLKSDPIVTLKDGDMVKVDLGAHIDGYMALAAHTIVIGATMENRIKGRQADALLAAYYGSEVALRLVQPGNENIAVTDAVQKVSDTFKCKPISGMLSHQTKQYQMDGGKTIIQNPTDIQRKEHEKCEFLVHEVYAIDVLITTGDGKTREMDSKTTIYRKTDENYQLKMKASRVLFSDIDKKFANMPFTLRALDNEQKARMGVVECVKHKLLEPYSVLYDKDNEMIAQFKFTVLLMPSGSHKITGLSFDPSICESEYSIEDESLKTILAKEGHAKMELKELLERQSLAIRLAKQAGEIIKKASGNMILPDEKCSFADLVTESDKAVEKMVFDEIKKQYPDDKFIGEESANETDEWSDDPTWIIDPIDGTTNFVHNFPFCCISIGFTYKRQPCLGVIYHPHLDHLYTAIKGHGAKLTKSNGEIIDIHVRPCPSLSQALVVAELGSQRDEAKRECVFKNLESIGWASHGIRSLGSAALNICSVASGQMDAFFEFGPYIWDICAGVVIATEAGGHVCDTTGGQLDLQGRRFIFASNEKLAKEIATKLVVQLDLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRK6</accession>
    <name>A0A922HRK6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRK6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="418" mass="49916" checksum="BC3BC585C40C9F99" modified="2023-02-22" version="1">MARKKIREKFLPLLSVFIRMVNPIDYWHHLDDDYHSIVCPTIHSSLIHSAINLFFTISIIRLSFLLIIRLPFEYCILFFDMKCFQKIDPIFDLFYILIFWALKTIEYSYYNTKHRMTLDIIRKLVFHSDKSFFKLSNKFIASNKNIYRSGRTPKELCRKSRLIAILLSRFVQIAIIAVNFLVIFWQCQLIYMVIMNRSFFLNSWLMTPVKLIISESMFLCLLGSYYATIHYLLQFGLLFLVGIIATRLRFQQLEEFLLDNLHNKNFISLSMLKWFRVEHTKTVRFVSNWNSIYSKCFTMYLIANIPFNLYIVIQLLFAKSEQIVIIMLSIMASQQFIGIFGAHLLIASIPHGIHHRSILHLISLNLRLRFRTFREHLKLINYNEKFHTKKPYGLTYYRMNLITTNTFLKSDLFFNCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRQ0</accession>
    <name>A0A922HRQ0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDK-activating kinase assembly factor MAT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CDK7/cyclin-H assembly factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Menage a trois</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">RING finger protein MAT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MNAT1</name>
        <name evidence="14" type="ORF">DERF_011169</name>
        <name evidence="13" type="ORF">HUG17_5940</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRQ0"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057657">
        <property type="entry name" value="MAT1_CAK-anch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25811">
        <property type="entry name" value="CAK-anch_MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7643578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9506436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="336" mass="38855" checksum="6A604D6133F8CC76" modified="2023-02-22" version="1">MDKETRCPNCGTTKYANVNLRMMVNVCGHSLCESCVELLFVKGAAKCPTCQVLLKRVQFRIQLYDDETVEKDLEIRRRLIKDLSLKEDDFETLREYNDYLELFETFVYNLANNIDVTETNRLIEQFKSDNAAKLAKSRNKISKDMELIQQLLEEELMEQGNRSMMSVDNDDDMNLAAKKVAQYKENLLDALVHSDMPAEIILRTHQKQAENELAAIDEMEQKRQQDALRMKRQQMNKQKIITSTGVRLGQNAKIVFDKEFNEIQGERFVYTPIKMPNAGPQCPTPGTIERKQYMQHVRMAGPSELAAGFFPIYPCQRALQEAIMDLTFIPRTMESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSY5</accession>
    <name>A0A922HSY5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9500996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="678"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="727"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="822"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="852"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="883"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="940"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="973"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1292"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1317"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1402"/>
            <end position="1428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9500996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1441" mass="172844" checksum="4BBE294BF0CC4CC9" modified="2023-02-22" version="1">MFWKIHQLFYHQLKEIVECRYNRWYRIKYTFEIVLLSIVSIRIMLTMISYMIDETFIQYWTIDPFCFYLIKAFRRLYRQYLMFAFILTLLGILGKFIFFFARVDTSTFRTPYELVVHNMEQYQHCKRRKSEINMIMEEYFRINYQNIFKSYRLVPNIFIRLFCRYQTLWQTYVDIYPIQVDTKKWIHMKPLRTPLHVLHDDRIKIIKFLTLIDPFIIILHIVVICLIVSYDYYNTIVDNDYDNVVCKIVKILDLILIIHNVFVIVQCGLIFVIMALCYGIFLKSHSNRLNYQLQHIASHCRKRNCQTISDEKYTLKPLLKQTIMFLEWIYHQHSYACYDLLYCYQEIWSNALFGYLLISIPFNVIAVITLSTEQLTLVEMIIQYMIIMIHALMTILSLFQFSNETKLINQPKFYLVPIIQSIVFIDRTTILLRSNYNHSITLRLKLKYDDLFNRLTNGRKYGPNVSTMGAITNMFIFNLAITYVEIVECRYNRWYQTKHTFEIVLLSIFSIRIVLAMISYMMDETFIQYWTFDPFCFYIITSFRQLYRQYLMFAFILTLLGILGKFTFFFARVDTDTFRIPYELVVHNMEQYQHCKRRKSEINMIMEEYFRINYQNIFKSYRLVPNIFIRLFCRYQTLWQTYVDIYPIQIDTKKWIHMKPLRTPLHVLHDDRIKIIKFLTLIDPFIIILHIVVICLIVSYDYYNTIVDNDYDNVVCKIVKILDLILIIHNVFVIVQCGLIFVIFALCYGILLKSHLNRLNYQLQHLASHCRKRNCQTILDEKYTLKPLLKQTIMFLEWIYHQHSYACYDLLYCYQEIWSNALFGYLLISIPFNVIAVITLSTEQLTLVEMIIQYMIIMIHALMTILSLFQFSNETKLINQPKFYLVPIIQSIVFIDRTTILSRSNYNHSITLRLKLKYDDLFNRLTSGRKYGPNVSTMGAITNMFIFNLAITYVEIVECRYNRWYQTKHTFEIVLLSIVSIRIIFGMISYMMDETFIQYWTFDPFCFYIITSCRQLYRQYLMFAFILTLLGILGKITFFFARVDTDTFRTPYELVVHNMEQYQHCKRRKSEVAQMMEENFNENLKNMNKASRFIPNIITRLFCQCQTLWQTYIIIYPIQIDPVELMRMKPLKLKQSVMFNDRIKIIRLLTIIDPIIITLHLGLLSIVLVVFYDFYLTVIAQNKKFIYKVFRTIDFFMITHGLFVIVQCGLFLLSSSLAIGIFIRSRLNRLNDQLHRMAFGCRIRNSQAISTKKPQKPLLNRTIHFLDWIYRQHVHTCVDRLYSYQELWSNALFTYLIMSIPFNVIAVSGLVVEQLTWFEMIVQYMIIVIHTAMTIVSLLQFSRQTRLLHEAKLYLVPIIQSIVIIHRPPIAIDCISTKTLRLKLKYEDLYNRLTHRRKYGPYVSTVGVVTNMFIFDLFTTYIGVFIFVSTHIQSLISIGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUC4</accession>
    <name>A0A922HUC4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUC4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08946">
        <property type="entry name" value="SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF23">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="332" mass="37181" checksum="1EDA640F945F70F0" modified="2023-02-22" version="1">MPECTNDRLISFVTNEHVLVTGGAGYIGSSLVPQLLQHGYLVTVFDQFVYGISPLLAVISDPNLTIIKGNICNKDQLRSVLTDDITTVIHLAAIVGYPACDENPELAIQVNEIGTANIVELIQSNQKLIFASTGSCYGAIEGLCTEETPICPLTLYGQTKSKSEDMILSKHGVCLRLATLFGVSQRMRLDLLINHITQTLLNEREIELYEANFRRTFLHVRDAARSFCFTISHYQKMKGQIFNVGDESMNMTKKMAAQKIIEQMPFPCSIRASLTGQDKDKRDYEVSYEKIKRLGFRSTISIEKGIEELLKTIPQMSVSEIKLSKKYLNDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUM7</accession>
    <name>A0A922HUM7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUM7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="10109" checksum="09CACF6C63E88863" modified="2023-02-22" version="1" fragment="single">SRQPQNRPQQSRITQNRPQQSLIDVDIGVDIGQYQRSERRCLARRRHTERMRLLRQQQQELVTTVMDLCNLLQNPARGPPPFFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUU9</accession>
    <name>A0A922HUU9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein 177</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009908</name>
        <name evidence="2" type="ORF">HUG17_0003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUU9"/>
    <dbReference type="OrthoDB" id="110174at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026620">
        <property type="entry name" value="TMEM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7644465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="38382" checksum="C911EFC3F8EB5C88" modified="2023-02-22" version="1">MLPLLRQKFRNLYDTIRFLPKVTRRRIYLAASITATMTTTGIYVGLQTIKVDTFVNHLQMYRMKAPMPVNDKLDHLLDQTIENDGFEFDRRGKHQLHLFNTFGCDIYSIGNVYLPTGAYIGVPFTFNLESTQQLDTNDIRLLGRYKTKRTRDSPVIKKLFQSLILSDDAKRFAFAHQLHLLSSSYFLIKSLNIMTMTALYMWIVPRFNRLRQVDNRPSRLLPRTMGAFLCLFLVTSMTIVADQLLDYIYDLRSLRQTIRRNDQHLKGGQEFYEKLIQRNQAMFELLGEQGPKIFTSNGHVKRLFGLYTTSYETHLDYINLHHHLTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVJ7</accession>
    <name>A0A922HVJ7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_010261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVJ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="339" mass="40164" checksum="6A0C542EE884D7BE" modified="2023-02-22" version="1">MLRNWRWFNGPQTKRFVRRVRLNILFHPKHSILILIITIGLIYVLYQLLFSPFISNHDSYDSQLELLTNMNKCESMNPLAMLVFETFVRRIINTFDMLEVTYFLCYETLWSTLKRANGDHKRKNGSKIRLKITDACFNLCILNEDLQRHDESIIERRFRNNGIQLHYIHSDGIYVLKPTTRLIDMTIPRDLDADGIREKKIDEEELHPILFTIHARIHVFEKDSQEDMYRRIGWRSRLLPSTMCKQLHCFPTNLIDNNDDQVITNSSNKNDRQQQQQQQQKSRQSTMGQLPKLEYLPSLFVNVPREGLEIQKYHYPDTWWTMTDSVDECSLSSSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVM3</accession>
    <name>A0A922HVM3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c oxidase polypeptide VIIc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009702</name>
        <name evidence="2" type="ORF">HUG17_7546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVM3"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7637340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8713" checksum="D3F3FABB773CD5E1" modified="2023-02-22" version="1">MISSRVLNLIPKSVMRQSLARSHDHKEIVYKGANFPFDTYNSRSLAIKMIIFFSIPYSIPYLVWRRRLARNKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVM5</accession>
    <name>A0A922HVM5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium channel flower</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CACFD1_2</name>
        <name evidence="16" type="ORF">DERF_010729</name>
        <name evidence="15" type="ORF">HUG17_9637</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Homomultimer. Associates with the dally/ magu complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Presynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calcium channel flower family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7642946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVM5"/>
    <dbReference type="OrthoDB" id="9934994at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7642946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9505967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="166" mass="17655" checksum="9BDDBC072BEB7DF5" modified="2023-02-22" version="1">MMDPMSPNANGQGPQSTWWVESWSSQITTGLAIFLVICGIITAISPINIGCIVPGILQLVASGIILSIEAPSFVPFLAFARPIGMFIEGKPYWFKGAFYAALALIPFIVGLSFGCIGFFFILGFLANGAIAALYGKIVLGRKANRDEMRFQAGGGTGQQPYSPTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWL9</accession>
    <name>A0A922HWL9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DmX-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">DMXL1_2</name>
        <name evidence="2" type="ORF">DERF_011193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWL9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="372" mass="42384" checksum="F905C43F9DAF095B" modified="2023-02-22" version="1">MLRITELNSIDGLPPLPMQLSWVRDGILVVGMDNEMLIFSQWKIRLPTSLPIVFEQNLNTRASHRNSLAFYYPFNSVEFQSDRLFIGNKENKMDEQQQQQHEQKPTTLTSSIMFASGGGGDKIISDEFEDLGAFESFHNSSPVIPQYHPKQLMELLAFGKIHRVRAILSHLVYSLCSINSVKEYLHHPANMQQQHSSFESSSDRSPRQWTRTRALSVAAQHSPRGDVYSGDSYGDANAAPIVAEEIQLDYTEIASIRPLPLYALIQADEGVTKDNKTTTKDNDNKSTAKDSGLSWNLDSTETLDSDFLEYNYKTQVEETLDEFLGNRTAFNFSNVATNKYLKSQQSQQQQQHKILILSYIFQLILIKNKLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWQ1</accession>
    <name>A0A922HWQ1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_009166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWQ1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050479">
        <property type="term" value="F:glyceryl-ether monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006643">
        <property type="term" value="P:membrane lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051689">
        <property type="entry name" value="Sterol_desaturase/TMEM195"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624:SF1">
        <property type="entry name" value="ALKYLGLYCEROL MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624">
        <property type="entry name" value="STEROL DESATURASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="8">
        <location>
            <begin position="155"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9510649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="680" mass="77896" checksum="B3761F148FE995BD" modified="2023-02-22" version="1">MVVPPSSSNSDSIIGSIPAQIAAVNHNNITTTNDHTDAFHHCTSLMAQGLVEQLGWMFYYVKPNSSIFMNVDDVPNYEVQIFPIFGVLVIIEQMIRLMQRKRFSRLSDVIVNIGAGLIFVAVRVALLGVVMKLFYFLYDNYRIVDLPKNCVSTWFISLLSVEFVYYWVHRSLHEINIFWASHQFHHNAVEVDVSLLIWSSMSFPNTIGIVCTATNPIGTYAIFIDLSSLAPYRSCITFRSIEYIINTPRQHRVHHGKNPWCIDKNYGALLMVFDRIFGTYQAEEEKIVFGTTEKPYETFDTITLHFYYYYDSVWKKFKSMNSFGDKMKALFYGPGWAPGKPRTGLLSDIPPVDIHAPIERYDCEISFWESFYVMLHSFIIAMGFYIITDHPLVRNSPLNAMIIISIGPLVESSRCLLFFPFDSYVMQPWIEQLTPPMHLHGFIDYMLGLIRLIHIVSIAVWLILWFRNARRNPKSFKAELLLASDNKSTLLKEDKCISAFAYSNNINVINQRRPWAIALYAVTMVISLTFMFSFCTSFRSFKIISPADELILHTESFILSHQHSISLLKSEINLYKQQISDLKSINDDKFHKIVEKIESSQTSQSSVTYSSVAQNSSVRNPIPNYKTILVKPKNSLLSPPQVKEAICNSISTYDLNAIKSLSINLTWLSNSPTNQVKTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX26</accession>
    <name>A0A922HX26_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX26"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="485" mass="56058" checksum="C1802DBB2C025D5D" modified="2023-02-22" version="1">MIDESPVAQITTLTKYNCNETEFHDESGEISFLDGDKICLLNTVVNNSLVGYYHVQTSSDNDYIILTIQFCGYIDNKLIVVDENSGNVLSSFIGKESDGECQHEEIQTFISDSNKIRIEFTAFDNNQAETHFAQNKRKVKFVDDDGHPCIKFSVTHKTVKFRSMEIHAENDGISRSKIEIDHYEPNSVWTHVVPKAEESETEYKIGVQFEIVYLDLDFDKNDYLLICPGMQPKLWAHTKCQIITRKIASHNSEGMKFWINADSAFLRVVTHNSLKKNVKVLEAYSEIANKTIKKSKNYDIPNRIKLASTQLCFEQLCINWRTTTKKEFLQEYVYHLNNYLVEHESNISMLIDTESVLIIDTRNETISSSRYNVVCRVSLAVTSPYDPEYPLVDGDTLHEMYFGSKTSIMFNGIRVTDCSYMNITIQEIIIPILIIIIVFSFITVVFWRLQTQLIKNRYTPIKRKNNQSESKLNLAEQPNEDFMNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXJ6</accession>
    <name>A0A922HXJ6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DnaJ sub C member 15</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit tim14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DNAJC15</name>
        <name evidence="11" type="ORF">DERF_007254</name>
        <name evidence="10" type="ORF">HUG17_1698</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TIM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXJ6"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7646160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9516519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="116" mass="12469" checksum="7665681265CA0196" modified="2023-02-22" version="1">MSSGVILAGLALAAIGYGGRALMRSSKTIGDTLSKSIPSSAFSNSKYYRGGFEPKMTRREAGLILGISPSASKNKLRESHKRIMLLNHPDRGGSPYLAAKINEAKDYLEKNSRPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXW3</accession>
    <name>A0A922HXW3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXW3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="84" mass="9283" checksum="BD0BC891618C7413" modified="2023-02-22" version="1">MTTTATSYDNMIGYCLDFFFSLRKSQIHLNFSFIFCSFHVQLFKKKLNHLPSLTLSSSSSSSPSPSPSPSPSPSPSPSTFIVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HY69</accession>
    <name>A0A922HY69_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HY69"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="720" mass="82783" checksum="22FC0B2512FDDBE2" modified="2023-02-22" version="1">MMTAIMNACIRTGHVPYLWKISTVRIIPKPGKTNYGQTSSFRPIGLLPILGKILESIMAGRIRRSLATNCPMSTNQYGFTSGKSTIHALDQLMCRIDHQQRDGNHVIMASIDIKGAFNHAWNPGIIDRLVAKKCPDYIVRIMANYMDDRRVVTTYGGTTLAKTTNRGTVQGSVMGPLLWNLIIDEFLHKDFGANIHVQAFADDIAAVIAHRDLNQLGILASKFMRMATDWCNSVKLHMSAEKSVIMYMSRKLRLPVLPTIMVDNRRIDYVEQTKILGVTIDRKRDFRPHLHLVIEKTTRIYRQILAMVHRNLGMRPHILKMIYRSVVVPTITYAAAIWKHAIVFKYMWNHLRQFVRPWAQLISGSYRTASFISTTAIADIAPLELEIMYEASVSLARIHGNYKFGDDFIDIDIPDCADNMVDLPPNIVANQLFACTYHHFITKIVRMRHSIGGCFAVYNGTYHIVTKYYRFPPYCSNLQADLFVILEAVNFAKEKFSSAAVITIINNNIGAIKHILKNDRKETINLARKIMMAMTNNNMTIHWQKVNPTDQIWHDVRKWARDAATSSLEFKFNLMPMSYVKKVERKRLLANWNKIYIEDKYGSNIKQLHPNVDDVRKFAPFVNKWLTMSLTGHGQFGKYLEKIGRRDDANCQCGLSEQSVHHLKFDCPLMNEPRYRFDMARRNCISPIELIKLEVVFYEQIAIRANELNNGIHQYHTPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYT3</accession>
    <name>A0A922HYT3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYT3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="7951" checksum="AFBECBA9B860F2BE" modified="2023-02-22" version="1">MICLGSLQGGSRKQPRPSTVTTLLNQKQNSILSPKRILLTECDPPMYIVSWSPSELSLPNWFQQRPKLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYV9</accession>
    <name>A0A922HYV9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">DERF_009302</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Derf</strain>
            <tissue evidence="21">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">Derf</strain>
            <tissue evidence="21">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="16">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="18"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYV9"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 16 18" id="KW-0274">FAD</keyword>
    <keyword evidence="6 16 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
    <keyword evidence="5 18" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="19">
        <location>
            <begin position="69"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="20">
        <location>
            <begin position="519"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="74"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="463"/>
            <end position="464"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="17">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KAH9510796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="669" mass="74057" checksum="4746E9EC44EE6CA6" modified="2023-02-22" version="1">MINLINSKMSMRLLQKCVRLRSNSSGIWMSRTNNSTMFDNILHRNISTTSLCNDKSNLKSYQVIDHTFDAVVVGAGGAGLRAAFGLVEKGFNTAVVSKLFPTRSHTVAAQGGINAALGNMEPDDWRWHMYDTVKGSDWLGDQDAIQYMTREAPKAVTELENYGMPFSRTPEGKIYQRAFGGQSYNFGKGGQAHRCCAVADRTGHSLLHTLYGQSLRYDCKYFIEYFVLDLIMEGGACRGVIALSLEDGTLHRFRSKNTILATGGYGRAYFSCTSAHTCTGDGTAMVNRAGLPSQDLEFIQFHPTGIYGAGCLMTEGCRGEGGFLVNSEGERFMERYAPVAKDLASRDVVSRSMTIEIREGRGCGPQKDHVYLQLHHLPAEQLALRLPGISETAMIFAGVDVTREPIPVLPTVHYNMGGVPTNYKGQVLNYSEEKGDMVIPGLYAAGEAGCASVHGANRLGANSLLDLVVFGRACAHAIAESNRPGESLPEFSATAGEASIDNLDRLRYAKGSLLTAQLRLKMQKDMQEHAAVFRTGPLLKEGVEKLKQDFKMLDDLKVMDSGLIWNSDLVETLELQNLMLNAMMTVNSAEARKESRGAHAREDYKDRIDEFNYSKPLDGQQRRSFEQHWRKHTLSFVESDGNVKLWYRPVIDKTLDEQAQTIPPAVRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0H5</accession>
    <name>A0A922I0H5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0H5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="7895" checksum="85D66CD1E4819378" modified="2023-02-22" version="1">MFGRVISVGNAGNGKTPLPRTNVVNISVASLQSARAKLIVELLIHQQQSSPASAAQMELRRLQFVEQQLPAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0X5</accession>
    <name>A0A922I0X5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0X5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="80" mass="9117" checksum="F2B192CDC84C22F0" modified="2023-02-22" version="1">MNLHSFQMSLYPLDIDLIFLLLGDEELFRPNDDAFDLAISDCRFSDDMLLFDVNVRPVDAPNFDFCVIVVGVSIDESLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1N4</accession>
    <name>A0A922I1N4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HMHA1_1</name>
        <name evidence="7" type="ORF">DERF_006584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1N4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20816">
        <property type="entry name" value="C1_GMIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="145"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="209"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9515810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="456" mass="52262" checksum="5F9EBD4F40236E8F" modified="2023-02-22" version="1">MAQRTRLCVTFEMDHHNQEDVTILDMDNNDRRYSYTTTTNSNQSSVDRLCLQDTNVQEANRRYSSELGRSIKSTSILPKVSRAKSDIILNSIGSISIDKDGQNNVDDTTSNHLDDKKKFENKRTNATMKKLAGYINVKPRLKYKEHDYQRITYVLNMKPTKCRICSDNIYFYCYECVQCKLAGHKKCLQNLYVTCPNKVMPPRLAVFGLEISDNNQISDVLHTCIIEIEKRPIHQLRGIYKLDGDSTNIEKLCLSFEFGSHLIDISQISPHDIAGVVKHYLLCISTPIFNKNIQKELITIGSEWPVRKVPYTQSGIAILVFELRRLVGCLTATYRNNLAYIIYHLKRIVDRQHITEMTANSLAIVFAPIIFRDERNIQHEYKTGSNDNDNNNNNNNNNDRIKGNSLSSSSSSLMKNGLSNNHNNIGTMHILLDVHLKIRVIELMICYANDIFANLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I238</accession>
    <name>A0A922I238_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_004293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I238"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="157"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="427"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9520591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="597" mass="68426" checksum="654C21859A02708F" modified="2023-02-22" version="1">MEQEYFVAINRINLVNDDDYDKNDGNNNKLYVNKLQATTTTTTTKANQIDLSIDCCCQLITFSSSEPIFSDYYHHHHHNHHHETMRSMILSTPEQQQQQQSLLTIVTTTSITINNKQQNHLMKFQTGYFDLWYSLILLSIVALLWLTPIKAAIRPSCRCIIFDDTFGKEYGVFTSPDWPVPYEDNIDCLLYTFIAQPDHIVEITFDEFDVQKSLEITTSTKTKTTTTKTLNSNSVDSGCDHGDYVKLFLHLNTDDDNDGIDETTVWNPPLLCGKFPDIEQTHFSSNSILIFEFHTDWRSGNNTGFRGTFRFLKKAMFRTDGQLISGTSCDYRFDHESLKLIRMSHSVDINEQQQQQQQQIVVHSSNSNIESNRFISENNNFNDDDDFDANIQRIKRMKGKNLSTFSINQKSPSSSSSSSLITTKQSMFNTINNNRTKYWVGQRGYFFSPQYPSTYPKRTKCSYRFRTNDPNQRVRLLFVEVSLQRDDQSCISNSDVIQIYDGIDSNADLIQQICGHIAFLEILSSTNQLYVEFISPPNTPKQQSAKGFKAEYSFIPVTALIQPGTLSLSPFTPPLMNYFPSSSSSSSGIQYPWLIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3V8</accession>
    <name>A0A922I3V8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3V8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="88" mass="10498" checksum="0A440B5A84CFBF6E" modified="2023-02-22" version="1" fragment="single">MEKIKINISLRFVSFFTNVATFNSIVTSSSSSSSFVTKKNNRMKNHHHHHHHHHHHHRLRVTIMFNSIRQIGGSHYLWVEKDRETENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4G4</accession>
    <name>A0A922I4G4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4G4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="7113" checksum="471B8CEB526159AD" modified="2023-02-22" version="1">MMTIIDVEPELKKTSLQVLSSLKMSIMYNVYVVLMYHYIVMVKLIPENHMQWLARAPKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4N3</accession>
    <name>A0A922I4N3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein Ciao1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CIAO1</name>
        <name evidence="3" type="synonym">Ciao1</name>
        <name evidence="6" type="ORF">DERF_005120</name>
        <name evidence="5" type="ORF">HUG17_7636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4N3"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="339"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7637430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9521462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="384" mass="44215" checksum="0FC450500AD16D75" modified="2023-02-22" version="1">MDNYEIKLENTLSGHIERVWCVRWHPNGRWLASCGADRTIKIWSKEGDEWKCLSTLTDGHQRTIRFIAWSHDGRFLASASFDGTTCIWHQKANENNDEPTTMDWTVMVSLEGHENEVKCVAWSPNNTFLATCSRDKSVWIWEKIEVGCESDDCGGGGGGDINDRPDEEAFFECSSVQTEHSQDVKCVVWHPKLNILSSSSFDNQINLYCQNDDDWQCYTQLNQHESTVWSIAFNPEGTRIVSVSADESIKIWQPKNYNQLIDETKLSGKRYAELTVKWTIIASLSGYHHWPIYDVDWSSIENLILTAGADNSIRIFKQFQNDQDDPYSSVRYRQILYESEAHEQDINSIHWNPVPISNSQLLLASGSDDGFVRLWSFEQRKQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5E7</accession>
    <name>A0A922I5E7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicastrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_006418</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nicastrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5E7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007220">
        <property type="term" value="P:Notch receptor processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041084">
        <property type="entry name" value="Ncstrn_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008710">
        <property type="entry name" value="Nicastrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21092">
        <property type="entry name" value="NICASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21092:SF0">
        <property type="entry name" value="NICASTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18266">
        <property type="entry name" value="Ncstrn_small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05450">
        <property type="entry name" value="Nicastrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037265491" description="Nicastrin" evidence="11">
        <location>
            <begin position="18"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Nicastrin small lobe" evidence="12">
        <location>
            <begin position="46"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9522862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="811" mass="92611" checksum="8A87A082537C95F9" modified="2023-02-22" version="1">MKHNTFIILIIVVFSDAHLFDRFQSHRIDQLIYRRYESISGDISFCIRRFNLTHSTGCSSSKHGNNGHPYQVYNQLDMKEKILQKQYQLYGPIILLINIRDFGSIEYLRQYRHRLVELVVGVIFIEYRKQSIVSNSSSSSSLYKSYSQESDCPNTGYGIRIVDKNNRTNDECSPRITGPNPYENYAKISWPFPIFLVRNKLAIEEFHQCQRQYNCRLQLKSFMYGTLNSQRCLQRSQNAMDMVESSYCKLIRARNLLATLFPIYENQSRFENRSILMLTARLDSFTMFDSYSPGVDSVYSAIIVMISIVDTLNRNQHLILPMNRTGSQIKNILYAFFDGESFGHIGSNSWIFYNNFMDDNSNYGSILSSKIKLKSIKQAIELNQLIGGGDPNDNEYWIHSDNDHVVDQNDGDDELISIAERFSRFCKRNKFSISTQQSLPSSCTVKQFRRYDPNIDALLLASYGSEIRNPYFHSLFDSRDYYDLEIIVKRLHVIADLVSNFIFELLTEQQYPKYQLKSDKNLIRNLVDCLIGLVPQCHLFDSKLNISGVNFEFTAPIQRETDMMINTIETRSSNLKQRMQSNIDVKRSLQTILFYANAKKINCSSSSSIVDQDGTSFTIIPLGQNQSFFDHHHDYRSFIAIGDGSGKNHANAAAGGGGGGGGGGGYCLVSQTVMELSESTYAEYIGKGLLLLADDVELLRQKMNELMATATGVQFSSWTESNYHKNPANRPVIMIFIEQSIWMKMFSIIIGMAITAISIWSIRLIERNPEKFFLNQTNGNFDSGGGFVTIAGQNEIRTLSTTMSCRINGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5I0</accession>
    <name>A0A922I5I0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_006123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5I0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9522559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="331" mass="38821" checksum="A10BFE4232F58DB4" modified="2023-02-22" version="1">MQIIGNCLGLWTAMINHSCDPNAYWDIDDGGYITITTSSTIKPDTEINISYGTYANAYNFDERRKYLWKRYHFHCQCHACMKQEEQQQQSGNSLLNGSIGNDDDDNDLPQTYPTGIQFGKCLYCKQIDGKNFTEGGFSKINDEQLYNNQQCMLWKFFYLHYCQHYGENTGDNNNDDIVETIGNFLFVGKNSNSNLLHQQQQQQRQRQRQRQQFQMTKNRSRIIFLAAEYLTMTFPKNDNISDGDSNIRYCHCDRRILSLMVQLFMISLKIFIPENNEDGIKINDLHFKITKLYDHLFINHMLKMAKSSSESSSNEMNEEFLKIIRLSMKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I693</accession>
    <name>A0A922I693_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">DERF_008688</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd14554">
        <property type="entry name" value="R-PTP-LAR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14553">
        <property type="entry name" value="R-PTPc-LAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000036">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000002">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000001">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase F isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1448"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="52"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="186"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="283"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="372"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="467"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="565"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="661"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="794"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="895"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="996"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="1173"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="1543"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="1713"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="1825"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="2001"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="702"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAH9518090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2094" mass="238397" checksum="99FFF7299050A678" modified="2023-02-22" version="1" fragment="single">NKTEISPSHHHHHQRRIINNQSFRLTFILQLLFLLQIAIFPTNILARSDGHPSRIITPPKDQYVISGRVATFICSAIGTPPPQIEWRKNGRHLTTQRYSVYSFPNGSVLRIEPVKLVFDDHRRMMSNYPNVVLVCVPYAVATNTNTTVAAAAGWNHVSKFNFGPSRLRNRDNATYECLAENGIGEPVRATAILHVYPGVEKGHNALLPCRAVGDPEPQIYWLRDTIPVDMTNPRYSLYQGASLKILQAQEVDEGPYECVAENKVGTAYSEMASLHVRIRVVPPYFTIPPENIYEIMPHKDLNLTCVASGSPLPEVRWRKGAIEMNKDIIPRGRNVLTLTNVKESDNYTCVATSEHGSIEKTAQVIVRSLPGPPTNVQASDVTPTSVRLAWNYDFGSEDIAYFIIQYKPKNAGQFSEISGITTSFYVINSLTPYTEYEFYIIAVNTIGRGQPSSSITITTGETKLGSYPRNVQARPLSSTTIVVQWEPPEEPNGQVTGYKIYYTLNPNLPINSWDVQSVNSNELTTISDLQAQSIYSIRVQAFTTRGAGPLSPPVQVKTQQGVPSQPLNLLATSISATSVQLTWNKPSHTGESIIGYEIYWNDTFTNQEYKRAVPVVETYKLTDLYPDTLYYIWIAAKSRRGEGAATPPIPVKTDQYVPETPPKEVYVRAIGSRSLRIRWQPPEDSSVQHIIYYKIRYREITNEQDDDHDDGDDDDDDDENSYRTSISTNAEPIQLEKVFEINNSNRDTYPYELILNELKHWTQYQVEILAGTKIGDGPPSDPIVVRTEEDVPGEPRDVKVMAINSSSVQVRWIHPEDSEHNGLIRGYQIHVQEIDRLGEPTGEQLRFDVADGLAQEFNVTSLQPDTEYSVQVAAVTRKGDGTRSRAVNVKTAGGVPTKPEIFISFLKDDPRMSVKVYWTRPNQTFSQLLEYKLRYGRVDDTVRDEVIMPATETLKIIENLERGTRYEFRLSGRNSVGWGQESVTYLDTPEGVPSAPPQNITDRLQSPTTVVFTWDPPAYQQQNGKITGYGIHFHKLIDVTPTEYNTTNLRMVFSSLDENTEYKFRARAYTSKGAGPWSDVLQIMTPGDAPPAPTSVQALATSETSVEVWWDEMPFFNDILGYTVLYTQIAVEDLDLWFRQPKTMYAIRVAAYTRNGLGRLSELITVRTDPTEVPLNLQSTEVTTHTMTLTWKPPRKLDPVKYQITYGANKEFYDSQGVLQRLKIEPKTIFESSDTNEYKLIKLMPFTTYQVNVTAIASDDGHVYRPAAKIIVTTAMAAPKPMVKPDTIESKNKQLITVILPQASEEFGLISHYYLVVVPKEFADKEPDLYTIEELSSTPIDKVGPYIAAKWMRRSIPNTFSLGDGQKYNGFINRKLQKNVEYRIFVRAVVDTPQKSLFTSSPFSDLLSLENNMNFMSHEPTRVHITSATYDPKGVPIMGRTGDKSGPILVLSIVLAIMVVVMSIIACIVKHRRQVIKSTLNDTSMKQLIATVEPQDHMIHPSDPVELRRLNYQTSAMRDHPPIPITELENHIELLKENENQKFSQEYESIDPGQQFTWENSNLPVNKSKNRYANVIAYDHSRVGVPGSDYINANYCDAYRKPNSYIATQGPLPETFGDFWRMVWEQNSLSIVMMTKLEERTRIKCDQYWPSKGTEKYGEIEVTLINYEELATYCIRTFTLKRVGTFDLPREVRQFQFTAWPDHGVPRHPTPFLMFLRRVKSMNPPDAGPLIIHCSAGVGRSGCYIVIDSMLDRIKCEDSIDIYGHVTCLRAQRNYMVQTEDQYIFIYDAVLEAVIAGNTEVVSRDLYKQFQYLMQLVPGENCTTMELEFQKIATMRPNNDENKFISANLVCNKHKNRLMNILPYESTRVFLQPIRGVEGSDYINANFIDGYKYRNAYVATQGPLMETTDDFWRMIWEHNSNIIVTLTQTQEMGREKCHEYWPSERSQRYSYFVVEPITEYNIPQYILREFKITDARDGQSRMIRQFHYVDWPEQGVPKSGEGFIEFITQVHKTKEQFGHEGPITVHCSAGVGRTGVFITLSIVLERLQNEDVLDLFQTVRTLRTQRPGMVQTEDQYQFCYRAILEYISTFDMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I699</accession>
    <name>A0A922I699_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I699"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="94" mass="11377" checksum="6EB0240F0460684E" modified="2023-02-22" version="1">MNSTDKDNHLERTFIINDGLNNVNKINSDRIDEIVPKRWTEQTFDWKFIITHCLLFTFIIAMAMIFFTIYVVVFFHYIKQNKIDYHVIIPMNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6G7</accession>
    <name>A0A922I6G7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">UXS1_1</name>
        <name evidence="20" type="ORF">DERF_004599</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="6"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6G7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000150">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="19">
        <location>
            <begin position="122"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH9520919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="461" mass="53586" checksum="043CC839B6CDAE07" modified="2023-02-22" version="1">MTLPRVFYVLFLFVIFTLTIVFTNYHNLSSKHRFDDDNQHEQHRSKNEIDSDIIDNDIGNRHQNNTKLMGTIEKLHNEIEQLRLRLEQIETKNNFQSSKIVTNRKFFQKTKLLPYSEKKRILITGGAGFVGSHLLDRLLSDGHEVIVADNFYTGRRSNIEHWLGHPNFELLHHDIVNPLYVEVDEIYHLASPASPPHYMMNAVKTIKTNTMGTINMLGLAKRVGARILVASTSEIYGDPDVHPQSESYWGNVNPIGPRSCYDEGKRVAEALTYAYAKQENLSVRVARIFNTYGPRMHANDGRVVSNFISQAIQSKPLSIYGNGNQTRSFQYISDLIEGLVRLMESNYSRPINLGNPDEYTIQKFADIVLNLVHRDNEKIQHNKDDDNRFMQPYSYHHHHHIEYLPAKQDDPRRRRPDIKLALQILHWYPNITLIDGLAKTIDYFRLELKRSLEERKKTILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I845</accession>
    <name>A0A922I845_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">USP8</name>
        <name evidence="7" type="ORF">DERF_004806</name>
        <name evidence="6" type="ORF">HUG17_7756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I845"/>
    <dbReference type="OrthoDB" id="6511306at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF46">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="611"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7640289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9521133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="945" mass="108833" checksum="65B887AA5F072262" modified="2023-02-22" version="1">MPSATKQELHLAKSLDELKKRSEITRFGKTNIERIIEFSNKFYHEATIHLQKGDSERAYMFFHRFSTLLSYIHNESDKQKFLNALGNKATEVFEKMKYLTDELSERYAEKQKSYEDRKAQLFKQTTSIPGNAVKVDPFDVQMDDDDDDECYRSIDCKRLIQHIQSMSEINKILIIDIRSAENFTDSSIAANKLATTGEVNIINIPNDIITAGLTLSQLKKKISFGVAQDGIERRRSMDMVIIVDEKTVEFDKKFKSCLLADAFWKWDQSPDKIKNKPLLLQGGYRDFILTYPMYTTNPNSVSNYNPMTTLSFDRPNPEFNLYNFLDEDNKPPSSLMNNRQPAISTTLNENNVNFNSIASNALDNKSMKFPGIARPIMPDRSSKPIDKMPLNGSTNRMKTFIDRPASDMKTTSISQLPKANRSNLPPKPVYLLSSLQNGNKTNGSLENNQGDRQTDHDDDVGKFVESDMEMVENSLNVREQQNEVFPMDEEMSDYENQNSNNHNQNDSDSDNESIANSISKPLEMNNMNNKNDRHNNQPFSSSLSRSLSSPNIAQFEQNFHFNDTTSPLTNSSSPKFPPQIPLVDRSAKPFAINFRKTRDFSPQFSSCARIAGLRNLGNTCFMNSMLQCLKNTREFYEFLIAGNVHINLNSKFGSNGELTIELIELFKQMRYPSNFKHISPKDFKCAVSRHIPDFIDYKQQDSHEFLVRLLDRLHADLNRSKPDIIHDPIHKDPNFYDKLSIAEAARTFWSLHIRRNDSFISDIFEGLIVSTLTCLHCKSSSKSLEAFTCLTLPIPENAGRTTLQNCINLFLRGELLSNEVAWQCQSCRQKRDAQKCTYIWRLPRILIIHLKRFTYDGMWRQKISNFVDFPIEHLKMETTNDEIRVFSLYGVVNHFGSLEGGHYVAYSRNRELNIDWHRYDDQDVSPMSASDVVTQNAYVLFYRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8C2</accession>
    <name>A0A922I8C2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_005501</name>
        <name evidence="2" type="ORF">HUG17_3508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8C2"/>
    <dbReference type="OrthoDB" id="10445449at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7639475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9521879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="211" mass="24135" checksum="1209FBE78F4CCD54" modified="2023-02-22" version="1">MSSSSSPSSSNNNSMSSKQHQSSRHGGTPSNNRNRPRPVTPTGVGSSSNNVIRGPGWRTKPPVKPRVQHEFWHRPFAQVGTNQQPPQFTPVEEGYMIGYMDSRDFHFRKIQRLINWFHRNGPGTFSYARYLHRFKNLPEPVQITVSSTPPSRKRQQSRGERGVGFRTRGYAPRRGFYSGFRRQRFGGGGGGGRMMMQQQQRPRLQRRSNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8T7</accession>
    <name>A0A922I8T7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Golgi ph regulator-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Voltage-gated anion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GPR89A</name>
        <name evidence="13" type="ORF">DERF_005720</name>
        <name evidence="12" type="ORF">HUG17_3341</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>bromide(in) = bromide(out)</text>
            <dbReference type="Rhea" id="RHEA:75383"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Golgi pH regulator (TC 1.A.38) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8T7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051452">
        <property type="term" value="P:intracellular pH reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="11">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="10">
        <location>
            <begin position="293"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7639308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9522119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="469" mass="54817" checksum="1868C656B9FFC8B1" modified="2023-02-22" version="1">MAWINTQDLCVVLITQLLFFAFGWYIFVKKLFRDYEINHKWVQILFCVTLSISCCMFELIIFEIVDFLDTSSRYFHWYLSIYLMLFMLLVALPFSISYFLIENCFADGRSPIRWRSKFILTGILWLIFIIIFWEIGNPFPISSPRHGILSIEHQISRVGIIGVTLIAMLSGFGAVNYPYVSMSYFTTTVTSADLANAEKRLMQTWDKIIMKKKQISTALHNQKVSASGGQSIQNSNSFSRVSFWSYLKNFGASFDSTANVQQLQRECANLEEMSRQLFLEYVDLKWMEERFVQSRTIKGKFFNYLGYFFSIYCIYKIILCTINIVFDRVGRMDPITRTLQFLVNYIGIDVDVKFWSQHCSFLVIGVIVLTSTRGLLINLTKFFYAISSSKSSNIIVCLLAELMGMYFVASILLMRMNMPLEYRMIITEVLGDLQFKFYHRWFDVIFLISALVSIGFIYISRQQMMKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I921</accession>
    <name>A0A922I921_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exosome complex component RRP45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Exosome component 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">EXOSC9</name>
        <name evidence="10" type="ORF">DERF_006468</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I921"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11368">
        <property type="entry name" value="RNase_PH_RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033100">
        <property type="entry name" value="Rrp45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="385"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9522915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="511" mass="59032" checksum="761B175EB1F22B45" modified="2023-02-22" version="1">MSRTVPNCNRSFLIESLLENKRIDNRTFYQSRDLQVNFGLTFGSCFVQLGNTIIYASTEATLDEPRITRPSEGRFKVIINIGAGGKEKWLRNIERSQPTEAILTTRLLEKIINRINVLDLESLCLVTGKMVWCICTKLVLLNFDGNLIEAASIATIASLMHFKRPDATVSPDNGDIIVHSYEERNPIPLTLFHYPLCVTFQFMDRTHLKKILTENQEILPEQHEHLVRKATQLLICDPTEEEEDFLHNVLIICANVYKEIVAIQSIGPLSLRSFSQRLLRSCTDKAFERVRFVTNYLKQTLEMHVNTSGQKQQPFERYGFYEAMLNGDLCIIRDYDRHPVLGDEQHNDHHHNNGENDNEILEKIHNIDIGFGGPSKWAIQINEPLDMDDDDDYEDKEHEEQPKIEIRTAQLTDPRMENNDDYDMEQKKSTNRNKKTNNMNKQKWTVVDKKKAATDSDIRTTIKKFNEKTKKEKRAIIAAANVADDDDEESATVQLQWEFSKKSGKNSKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9C2</accession>
    <name>A0A922I9C2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_000822</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9C2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037340980" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="21"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="255"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="14">
        <location>
            <begin position="525"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9526760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="750" mass="87093" checksum="58252AE4DD387FAF" modified="2023-02-22" version="1">MNLLSPVLLVIITFSTIIESVDKSNFKTCEQSVEAVDQPKNKVVVQMNPFRLDVYSMGELVMVVNQRGLFNFEHFRHKPQEASETDPNTDCNENCWEETFKGSTDSKPNGPMSIGMDVTLIGFEHVYGIPEHADSFALKDTKGNSDPYRLFNSDVFEYELYSPMTLYGAYPLMIAHSSAPKTVGLFWLNPSETWIDIESSNTGIGGLLTNLVSDSKPNKLTHWISETGLIDMFFLLGPNAANVMHQNAQLFGTTRLPPIYSIGYHQCRWNYFSDQEVMDVDEKADIYDIPMDAIWLDIEYTDGRSKKYFTHDPVMFKNWQSMIQNLTAKGRRLITIIDPHLKRESGYPIYDEASSQGLLTKDAKEDKDFEGWCWPGSSVWPDYLNPIVRDWWADKFDPKLFPGFEGGIVDYWNDMNEPSVFSGPEITAPRDMRHMDNVEHREIHNIYGYLMTKSTYDESEEMMIRWYQASIFHPFYRAHAHLDTKRREPWLFSDFTRQSIRQSIRIRYSYLPYMYQLFYENEQTGMPPFRPLWMQFPTDSKTLSIDTSHMLGSNLLFAPVLDKEAKQLDIYLPSEQHKQTFWLDVFAHHVYQGGQEYRFEVDINSIPIFQRSGTIIPKRERPRRSAVLAVNDPISLQIFLNSNGSASGFIYLDDGQTFDYQRRNAFISGRFNYSKRTLTYTFDKGDPDSNRAWLERVTIVGYPSKPNRIQIIAAEELSSQLAFKYDQQKHLLVIRKPAVMFGQNWQIKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9H7</accession>
    <name>A0A922I9H7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">2 iron, 2 sulfur cluster binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FDX1L</name>
        <name evidence="9" type="ORF">DERF_000908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9H7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="8">
        <location>
            <begin position="345"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9526850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="460" mass="52858" checksum="C934CCBA57402B96" modified="2023-02-22" version="1">MYRFEILDTLMEFKLTLDTYFVSLIVIGLLLSIMSLILSILVNERCSTNLWNKVCLKQNNNDNKTLNSYRHIYVIHVVYFHRKSSIDFKKTKVMITFFVGTTEKISIQITPKFFRPNMYNETSKDYCVMKFLLFRNSEIKSVKNIAITHDDHKDGAEFYVSMISIQNTKQENGFICCIEQRIKSMPKEKCEQSPFPASPQSNMRLEGGFATPNCIRFLDLVPPMYLSFNLLFRECIDTNNDENNYVIGIYAAIRWFFVVFGSTGVIYGIFYQILAGKPIQMFCKLLSNSSFNARRFFQIINLNLNNKLISSPRNISFTSTLQTDDTSNNNNAAEDDNDDSVAEKIRVHYITNKGEKITVEGTAGDNVMYLAQKNSIDIEGACEASLACCTCHVYVRDDYFDKIPEASEEEEDLLDMAPFLKSNSRLSCQIILKKDLQDIQVTLPPATRNFYVDGKKPSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9J1</accession>
    <name>A0A922I9J1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000819</name>
        <name evidence="2" type="ORF">HUG17_8553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7641084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9J1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="190" mass="21589" checksum="6FD0CA4188D70F01" modified="2023-02-22" version="1">MKRTTSENVAKKDNQQTNSEDPDDPNQSAENEEEESFSLTKSAIDDLPSTAVQSIHLEVPEGQPSLVENVDEEAFLWKEYKMKWSKVRKQRKSFGPTSSRQQPPPVVGKQRSITKQQQQQTPQRIATNSGNVIVANNNKQQQPPTPGPKRNSSQQTIKTVEQNRKVVNQANSVVKSKERRDNVKKNKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9X9</accession>
    <name>A0A922I9X9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001134</name>
        <name evidence="2" type="ORF">HUG17_4366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9X9"/>
    <dbReference type="OrthoDB" id="10564828at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="364" mass="42574" checksum="4DA355139EB596CE" modified="2023-02-22" version="1">MDNEQQPDTNRLLNLIINTYGFVGIQLKPIKLNEIRSASNFIINILINIFIVHVFQSEIFYSGRSEFLTTLNYYMINQFHKLNKNVIFPLIYSGYILSYFANGHQFIQCLQSTTYSSSIQFSQNQSILVLMVATILSNIFCFIGVEKFQKSSIFNIISLEIFYFYESVTWILLYYHQIVNLNALRQIRDRYLESSLSSSSSSGHKRTISNYLIKCKNLFINVKQLADLNTRIQSILSYLLCLHILDSSSFLILSTTDLAAFNLESSYKCLIELPIRISLWIGLCMANKIVIMEFDRIENSIQKSLRSITTGLKRKKIFKYKEMEIFRESFQLIMFDFFIIDFALFMDWIIFIAGYVTIIYQTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAC7</accession>
    <name>A0A922IAC7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylinositol 4-kinase beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PI4KB_1</name>
        <name evidence="3" type="ORF">DERF_001870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAC7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIK helical" evidence="2">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="492" mass="55917" checksum="4FC3C63532BD2ABB" modified="2023-02-22" version="1">MNIANSQQSLFVTKNGSIDTTTDRQMDDGESKNKSKEKSETEMMICRPQTPMQQSWLLRLFESELFNMNIAITYLFNSKESGVLSYLGNRMFTFPPDDVDFFLPQLIVLYIHNNNIADAIHPYLIHRCRHSVYASTKCIWLLNAFCPETQTSTITPMLHSRKNKSLGHRLRKSILNEEFRLSTAAKADANLSNDMNNSNYLNHSLANAKIGHNHLRTHYRSFSDAMTKSQLSGTNLNQTVSTIGCIHHQQNQKNRFLRIPSTTTNVIMKNSNPNEQDNNLKQAFPSCLCAALRIKPEYEFIRCLMNIGLKMQSVPSKEIKSQLLISELSTLNIQLPARVWIPTYTKHSHMIVRIPPHAAVVLNSKDKAPYLIYFEICECDDIEKSPVPVKQALNNSRNSLNGSSNSINFLMMTNHNHGGNFNLNQQQKCPLESQSSSQTHSTSIIRQTKSEENLIEFSIKHGTTATLNNNLDQKFQFHVKILATAKATLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB36</accession>
    <name>A0A922IB36_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Down syndrome cell adhesion molecule-like protein Dscam2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_002189</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:nervous system development"/>
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    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
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    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
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    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1302"/>
            <end position="1330"/>
        </location>
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            <end position="984"/>
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            <end position="1109"/>
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        </location>
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        </location>
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    <sequence length="1586" mass="175707" checksum="B45181CB1026A218" modified="2023-02-22" version="1">MKTKVVEQRFVIEVYDEFVTAGNSALLRCHIPAFMRDLLDIIGWIEGSSNYILPDTTAFVSSSSSSSSSSLSSSLSSSSSSSITHRQNSDKYRILYNGELLINKVEPADALKSFRCQVKHRLTNEKFLSSNSGRLFVSGMYQVNQHHALPLIQPPRIIDTNRVIITEEGSTAEIVCLAQGYPEPTYTWYKNADLISDRIITESSSSTLSGLMSNNYLIPRFRILTNSILIEKVSQNDAGLYRCIVNNSIGSELAETQLIVRSPLNVQIGLPIIRIELGNSLTLNCTVSGGPIKAIEWLHNGRPISNMLASSNGVGLSSSSSSSLSSSGIGTIGSSSSSSSGGNVGGGFRIRLISREVLHISKVTRNDRGMYQCVAFNDFDSAQAQVQLQLGDNAPQLLSVFSEQTLQPGQPLSLKCIASGNPIPQVLWHVYDKLPIPDHLARYRIGDYVTRDSLLVSYVNISSILPEDGGLYTCQAINDVATIQHTARINVYGRPTIRRMPNMTSVAGESISITCPVGGYPIDSIVWERDSVRLPYNHRQKVFTNGTLTVNELERVTDEGIYTCIARNKDDIRSSAKTSFSLKVFVRPVIEPFKFPQSLHQSQRYNLLCTVVKGDPPIKVEWYKDGKKLTIGSLPHTNIIHVTDYSVTLAFESVQPDHRGNYTCVASNGAGSSSHSATMVIHVPPRWRIEPTDVTVVKGRNAIIDCDTDAYPEPVITWSRAEGLDINNELPSNFKPINSNGHYRSYENGSLVIHNSHKSDTGYYMCAASNGIGPGISKVIKITVNVAATFETKFRTETVHRGLEARIKCSANGDKPVTISWFKDKAPLMTTEDGRYDLIETIMNEGIKSELLIRNADRRDGGLYTCLASNSFGHDDTNIQLIVQEPPDPPGDIKIIERDGRSIRIQWSTPYSGNSPLTHYIVQHKPESEKLSSHYYNLTLVASENFVTLNGLQPVTTYQVRIIAINDLGQSEPSDVMFVQTDEETPGGPPLHLKAVALTSTSIKVSWKTPRKELQFGFIRGYYIGYRIIQSASSLDLSTSSSSSSGSNPTSQQSDFIYKTLEVKGKDNVEECIISELKRASRYEIVVQAFNSKGAGPSSEPVHVKTLEFDPPTAPTLQVTEVTFNFIRYILHYKRESSDWRELKLSNINTFTHENLRCGTRYQYYLVGFNSAGKGDPSQVVSARTDGTSPVAPDKNSLLSVNYTMVTIYLDSFHDGGCKINNFEVMYKTDRLHNWTPLTMSDQRTIVLNDLLPGHKYQIRVTAYNEAGSTEAEYHFITPMSSLQNDQAIILMGSRSTSSVPFYADVLVVVPSVISFVVIVVLLSLVYIIFTRKPRHTNNIYGNFNDQNKFTTEGNESVIMGELEAKYANNLNGGFNTNTDLKGYQIAGNGGGCVATMNQNVVHFQSPYAMSNIHEKTGNEERYPLNHLNMSPMKAANYSIEHDGIYATVKRTPRPPRSDVHIYQFPRGSTMATTTAVATTNDIINLDSESFDSPTPNNGGCPISNNNINNIGGGMESSTTSTINQHTANNHSNNQNTANWRTTTANTTIVQRFDPKEHHHQQHQETMAHMKKLTEIQYGHKSLFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBN2</accession>
    <name>A0A922IBN2_DERFA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBN2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="112" mass="12567" checksum="61612EF2A0765B39" modified="2023-02-22" version="1">MNGRNCKNKNQKCSHCSVCDQMNSGDNLPTTIGESGMRPILISNKRLSAPCVFSARHLYLIREFGRGFRISSIFLNVNINVDMLIESTIFVLTPPLGSLSIFNTYIEHEESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICN1</accession>
    <name>A0A922ICN1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein acetyllysine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SIRT6</name>
        <name evidence="10" type="ORF">DERF_002948</name>
        <name evidence="9" type="ORF">HUG17_4992</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the sirtuin family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="1"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICN1"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046969">
        <property type="term" value="F:histone H3K9 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000038">
        <property type="entry name" value="NAD-dependent protein deacetylase sirtuin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF12">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7641947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9529039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="319" mass="36188" checksum="A854DD0743F48B3F" modified="2023-02-22" version="1">MSANYASGLSEYKNKGTCGTKELIDSDKKLARNTKILAEWIRESKHCVLFCGAGISTAAGIPDFRGPNGIWTLEKRGQKPDESKVKSFDQCIPTFSHRAIITMINKGFVKHVVSQNIDGLFLKADIDRENLSELHGNYFVDECIECHSRFIRNRPSPTMGCKFTGDKCGQCDGLIHDTILDWEQELPDDEFDRAQIESEKCDLAICLGTSLQIEPANLLPLEVLKKSEIQSENTDVYDPNDDRLNKLVIINLQRTKFDRHADLIIHHYVDKVMEIICQQLMIQVGPYESALDPTKSSHDLIPWNRKDFKPTNKSRNESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICP6</accession>
    <name>A0A922ICP6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc ion binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Hr96_4</name>
        <name evidence="12" type="ORF">DERF_002269</name>
        <name evidence="11" type="ORF">HUG17_10232</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICP6"/>
    <dbReference type="OrthoDB" id="10511563at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF283">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="9">
        <location>
            <begin position="9"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="10">
        <location>
            <begin position="309"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7636262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9528317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="630" mass="73903" checksum="8EEC2A7B62767D70" modified="2023-02-22" version="1">MRRKSERIIRFCVVCGDKAKGMNFNALTCQSCKAFFRRNALSNKELKCSFENHCQIDKVTRKFCSSCRLRKCFNSGMKKEYILTDEEKRLVREKIIQNRHRREQQLKGITDNNNSNYHHHSLGSSTIPILSPFNNDDDNTNNVMNATVTSSILKPYPYNTLDREPANPFYTSAAKRFSPVNSEHTSDVYMMSPCSSTSIFSEQEPSMYINHHHDTIHGNIHFDSRDLDESMKNLQSLNIQQTPYKTGPGNVINLDVNYQQQSTMNFGAEKIDDTRRTENRSIEPKRPEMNEENCDDYLRYYLQKPNNSDDEFMIEAMNEFHERIAMNIFFTCDFKMIFSANDRLLLKELCTACTWLHNPYKRMLIIRNQHYLDDSPHDCTLVDSYLYRIIRMSKRLTSFTSLHLDDQVQLLTFGMIEIIALYSMLCFDPEFQGWSFIDDHHKMTIKVNIDCITPCCIKYDYKTSVKNFYNIFSHEWKTDYTIFHLLTAIILFTERPGLRDSAKIRERKSLYTQLLKNYLNLKYTENTDAKWAFDRMFLTVKAMQLVQTDLTLHLVASTAGKKFSPLLGQLMAQHLTQQQWQEDDKKPDCNINRLSNRSRIISLNKSATTTHSDSNQKTFRTVEHDNFCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ID45</accession>
    <name>A0A922ID45_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ID45"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="381" mass="43734" checksum="12AF20A5B3E8D789" modified="2023-02-22" version="1">MASTIIANKQIHEAYYIRTPLKVFIDLQNFFVSFDIIGHSKTSNDNNNTVAIKDQQSQNSEIDHHLQQQQQQQQQLLSTDTLLEGNHRFNKHNNNNNNHQNRKHNQDKGHYHHHNNIDKNIDDFIDETTNNENFDSVNLKRFKKEKQSNIQPLVALDAHVTENDNHDKGNNDNNNLINDSKITTNNCQLLNIHLAKQQQNNGDDVERKLISSDYSHHHKRSSIDIITRETIAAFEQNVQQESIDNGHDGNSCRRKNSIETNGHHHQTDQTQAKTFTNQSTINHYSPASMFDVKFKSYHNSNNNNNNQDNLFVSTSTNNNIGKNNFSHFINCSPNNNSFNSPTTTSTSTILNGSHGEKNSNNNCKLQLYTIGRIRIMDHHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDW4</accession>
    <name>A0A922IDW4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDW4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="91" mass="10342" checksum="11A8249A2F415630" modified="2023-02-22" version="1">MDSSKHKVVDSIKTHYIIITEGLDDIHNGRPPFDQISDQSSNDDYSGETMDDESEQNANDNDGVVDDENIRDKKVQDIIRMVQSSINNMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEM9</accession>
    <name>A0A922IEM9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">JNK_SAPK-associated protein-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RILPL1</name>
        <name evidence="5" type="ORF">DERF_003227</name>
        <name evidence="4" type="ORF">HUG17_5234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEM9"/>
    <dbReference type="OrthoDB" id="10069524at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RH1" evidence="3">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7642189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9529337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="331" mass="39147" checksum="72B216A250A70501" modified="2023-02-22" version="1">MQNSTKSNTNELELCEYIDLSISVESIYESASEIGEHFKKLIQLFGAETFEILISCVVRVLENLEDVTVQRNNCLKLVDKLHKQIDELQKDHQKRIQEQLKFQMEIEDIDELWRKENGKLEQYVKYLKNENNRLNSMKTSENLSHSLMNLKPENEINIEHSSICHQKEINNAQLDKLKTKIKILNNEIELKNEENDDLKRKLVNLDLENRNIRKIISSLINNIIDSNGEMSKNDQHNDTNNNDDEWRERINILEEKLIVIKQQLESKQNDIIEMAEEVQPSESEQIKMEDLPVQGPIPKEPDEKLYWSPRNNQNRSKIWSFFPKFTKSFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF31</accession>
    <name>A0A922IF31_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_004112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF31"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF43">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9530299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="149" mass="16910" checksum="165728827138385B" modified="2023-02-22" version="1">MVTMEMDMKNGSSHHGMMMYFHTEIGGDYILFKSWKPQDGKEMAWACLATVLFTIFYESFKVLRAKIQQQISNFDSGNKYTNMYHILQSILHGVQYLLSYCLMLIAMTYQLYLIFAIVIGAIIGNFVFAPLSTFETNSGSADFGDPCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFC5</accession>
    <name>A0A922IFC5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YtxH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_003639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFC5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9529772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9674" checksum="BD0445D6D69B77B1" modified="2023-02-22" version="1">MDKRKYTIMAAVTAAVFGAIGYYYYQKRDSIDEALKKTADTIKNQADVVKQKTDNAQKNIQEAMKELEKNIPDKSQKTPKLSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFN7</accession>
    <name>A0A922IFN7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFN7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="96" mass="11414" checksum="EF073D0DC4D42004" modified="2023-02-22" version="1">MYQQFYETVYQIIQQQQQQQKNKPRTNWGVISSTLSLIVLIVLLPFKVNCNCIIIKLLVDSRGNNGFILKASNFYPEIRRYFEEIFCFVSFDMYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFR2</accession>
    <name>A0A922IFR2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_004067</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFR2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000271">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="40"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="15">
        <location>
            <begin position="696"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="554"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="752"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="11">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9530248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="778" mass="88155" checksum="936120CC1DDBC5BC" modified="2023-02-22" version="1">MANNEPHQTNVNDKRLFNPTDATMEFKMTMEDICLEAGYYLHKKPLGEGGFGKVRLATHLRTNQKVAIKMMNKQKLGQDLQRVRIEVEALKVLQHDNIAKMLQIIETDTDIYLVLEYCSGGELFDYLISKRRLTETEVRIIMKDLFKVLLYIHNRGFAHRDLKPENILFDHNHRIKLIDFGLAANSSKNKAALAFLQTCCGSPAYAAPELLRGLTYSGPAVDVWSAGVLLYSLIVGQLPFDDENMNNLYKKIQIGRFMMPQWLSADVRDLISAMLRTNPAERITVAKALDHRWIRKGFTALSPSVPPPISQRCPLSPQSIDQKIFSYLEQLFPQMSEVELRGRLKLFGYVTATYLLLKHDPQSIKAVQELLQSRMKPLAQQQQELSTIVHHQPPPARIAAIKRKLQLDCDINHNQEQQTPSSSGGAGTMEPVAKKIARENLSTPKKPVLLNGIQQHSTTPKTPNIPLLAERKQMLVNSANATKYSPASIRVAATRLTPQQARKIKSPKLKKPVMNDENCSTIKNQSIKSPLTNNNNGVTTVKSPLRDMRNQVLSPNSSINDNKQTIQSIKQSPRKTTMVTPTKSSTSSSTKKSLLRRLMASATPTAKSHHSSPRKLDASTPSNNITMTSYKEPQECLDHLTLTLRSKGVECKQKKYVPESSTIRTMNRNQTFIKRKRTFIIRQQRRPSFTLKCFFTDRIHSSLKFELEICRFNGLCVIHRKRLNGDAWNYKKICELILQLSNEQQLAALNSRSNSGNKTMTQQQQQPSPCVIETETRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFT7</accession>
    <name>A0A922IFT7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_002517</name>
        <name evidence="6" type="ORF">HUG17_10483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFT7"/>
    <dbReference type="OrthoDB" id="294380at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7636513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9528584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="190" mass="22034" checksum="43EB9D5548FC5E49" modified="2023-02-22" version="1">MSVQKIIIVGDKNVDKISFKNKLMNLQHDSNVSTANRFLSWTINQQPLKVEFKIVEPDELQAVRDSFYRSANGFICLFDVNDEQSLTTVKKMREQILDVRSQTRIILVGIKNGDRDAKKLRKIPKTDSKRLAKGWKAEYFETTVDGNQNVENCLNILMKAIIENKHTRLVSGRTSIKNTLDRFKYYNCFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IHA8</accession>
    <name>A0A922IHA8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IHA8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7384" checksum="0CB103BA3D9E8F2A" modified="2023-02-22" version="1">MADGGQILEYHHHQMQIISIGSKKKFRTNKNPMKPNVDNVTFINDDQQLHCDCVKQAQCCWPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KRN7</accession>
    <name>A0A922KRN7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G-protein coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Pgr15l_5</name>
        <name evidence="12" type="ORF">DERF_015861</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KRN7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="35"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="312"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9491126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="521" mass="60809" checksum="EF25F0A56B1F8F65" modified="2023-02-22" version="1">MMRKHPMDITKEFQEQINTIVKDAYRQEHIYYGIACFIIVLISFFGNLLVCRICLQKCTKTNTLILSLAISDILMTIFNIPFNFFRIANFSWSFGSSMCFIVNFLQYVVVYISSYTMAIIAIQRYQSLSGFRHHFNHNYPSSSSSVVINNNNRHNPTTTTTTTTLIIHKQETITRTKSINSNNNDNDHDIEINNEIMINKDQHNRNIFNQIHQSFIQFKNLLSFYCCHCWKYCSTTTTTKTTTKTSNQSTNIMNNDGFTRRTIYILIIITWLSSALISLLFTYSSEVVAKEDIAYILHLFLLKNPDFSIPTNNNYDNNQTNNSYSNELNGQNPVASVDNHPHFQSSSSSSSSSLSPLNFDHKTMKRCRNPINENVKNFLLENFSIKADLLLTIIVFITQYFIPLAIVGYLYIEIGKIIHRQGKLCDDKGNARARIRQRKKFRRILMLIFMVAAFAICWLPLHIFHILTDAGWLQYNYRIFMVVSFIHPFCVFVHFYFPLHLFIRFFLFVSIFIHQIKIQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KS69</accession>
    <name>A0A922KS69_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014047</name>
        <name evidence="1" type="ORF">HUG17_3995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KS69"/>
    <dbReference type="OrthoDB" id="10599580at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7639962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="9186" checksum="A70A9A22EC46989D" modified="2023-02-22" version="1">MNTDRPIGFAIDDIDRSQHQQVNIENIRLTWIDRIWRFFYSKEEFEAYLIEKELKKQKKRERKLAREQQAQMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZ80</accession>
    <name>A0A922KZ80_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Low-density lipoprotein receptor-related protein 2-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_011255</name>
        <name evidence="5" type="ORF">HUG17_7134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZ80"/>
    <dbReference type="OrthoDB" id="6511229at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324737" evidence="4">
        <location>
            <begin position="20"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7636928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9506530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="190" mass="21226" checksum="3F2360A33FADED70" modified="2023-02-22" version="1">MIKSAVSLILTMTVISVMAMPSIHIETSSESLTAGGDESSRTTYDWGKHTGTYDYDKHTRTTFDWGKYTSTTDSSVETTTNGDHDHNNDDDNNDEDRHRCGSGKYSCAGTIGMCIDISQICDSKIDCPNADDEDKNVCQFHQRPNRRTANKINRFSGTGFQFHIGTLKIDSKSKVKMFNQDSDNTETRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZP0</accession>
    <name>A0A922KZP0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZP0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="105" mass="12409" checksum="9157EBE91DDDDD61" modified="2023-02-22" version="1">MAKTVFSQMIENTAVVGCCKYKILFINTMMHHLKQQSIQHREKIISLYIERYLSRMTTKNVEMDKSIKKKEKIPSSSSSYKSVENQSHFLSKYIIQMDDDDHHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0H0</accession>
    <name>A0A922L0H0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-associating domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0H0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RA"/>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21298">
        <property type="entry name" value="GH01721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21298:SF2">
        <property type="entry name" value="GH01721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="149"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="249"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="399"/>
            <end position="437"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="37"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="399"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9501841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="442" mass="50172" checksum="F8628E8F39C77C1A" modified="2023-02-22" version="1">MLKYVSTPMPLSYSTSPSSSSASNNPTMFDVDLKRQSSSSTSSDSISLNSSDSISNGSSSIMNDSIESPITHHHHHSNHLLVPVVNHHHHHHHHRSWSSSSSSTSSLPSLITDNVQLSLPTKSINNNDDHQNKIVSSSPTSTSSNTIDRKFVIKIFTRVLCTDVEYKTLSISNHTTSQEIVQIILKKFRLNHLDPNLFYLTLEAWIKQTGIPIRSVMALDDDACPALLQSCYRQKDLKFTLVMRRGENVRIHNQCKHGPSTVNILISERTNVEELTHLVTGILDLPTIDKQYELYVYSPSCKIEQKLSPTDRPLAIRMEWPNQDFNRFEIRPSSCRIQHHHQYIDNNNNNNSSNDSRLIMADFRKNFKSEFTMNLLGAATTTTNHNSMAIATENRNHYHHHNHHYPHYRSHPQLQLPQHQHSSSSSSTTTTTTTTTGKVLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A922L0K4_DERFA</name>
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        <name evidence="2" type="ORF">DERF_009194</name>
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    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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            <taxon>Astigmata</taxon>
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            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0K4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="341" mass="38996" checksum="0991D7A36881D19C" modified="2023-02-22" version="1">MLTYNQNKNFQNQNQLAVVPKQNYLVTTPEETESETIQQEQHPSTSDTNTSYFARKIKNEPTNDSDCESIIGLYCLEKQSLMANKIKKINDNKENLLLPITVNGMINSQKQKFILDTGSNINIITPKMCKILNISITNHVETIKTIGTQTKTTHICNTKVIIGEIDTELEFFVCEHPHDMILLSRSAIFEFNLHIGAGHQNKNEIIIYQKSIKQNPQKTAMKEETKKIIGKTESIKETIKEFNQASAKNEDDIDKIKEKKACINFKNETTTTRQANSYSEKDQSEIDQEKSKLLEIGPIKTKSNSTYCLHRPLSKVMVPSFKITKFRRHKRSTISSPPQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0T1</accession>
    <name>A0A922L0T1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_015961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0T1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9491230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="31387" checksum="C39B4FBB4E9F1FBA" modified="2023-02-22" version="1">MSTNSSGSSSGSTSQKIVKSNRSPIGNRNNRNNHRNRLQNNNPNNQMAQIKELLHLIPFAAQFLQQNAALVRQNLAVGSLAMVQDGEIKNLNRINDQFIHDNDNLHEDQRIDRQYIRQLQSNEQTFRMWATIFSVLFIGLAFYYWNQTNQMQQDTRRQIEIENKFAQLTGLIRNDKHYHKEQKFLEIIKQREQEIQMLRNRRHKSDKMTEAKINDNDFEHQNYDDDTMNIDDDDDMINRNIEQIQADVIDQIEKELNKMRNKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0V3</accession>
    <name>A0A922L0V3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein hunchback</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_009429</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Gap class segmentation protein that controls development of head structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the hunchback C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0V3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040034">
        <property type="term" value="P:regulation of development, heterochronic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035282">
        <property type="term" value="P:segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001301">
        <property type="entry name" value="Blast:Protein hunchback"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002883">
        <property type="entry name" value="Hunchback-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24392:SF49">
        <property type="entry name" value="PROTEIN HUNCHBACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24392">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0302">Gap protein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="546"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="636"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="748"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="877"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="555"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9510939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113194" checksum="C09A76EF0DC804E8" modified="2023-02-22" version="1" fragment="single">MSNPPTSMLSVNDNNSALIDTNNRSWSMMLGSPSLMPLTQPATSTTMESDEENPIADLMSLYSLPATSSSTMSQSDQHLHSMLLMAAMHHQQQQSLASIPTNVATSSGLVTTPTSELVEQQSHQNRLPLINTTGSSSINPAAYQHPILMMRMMMGNPSFLDHLTAPATSTSSGSILSPPNSSESTTECKEAAETTALMSPGIEEPSTTTTTIKSSKSSAKPKCAKRRQRVVNGTGKSRQLTKCYSINRRLVESTVSTTSIASNVDQESLSDNRSTNPIYRCHLCPYTGNSKLHFNAHMNTHFDHRCPHCDYTSRTEGRLKRHIRDFHSETPPETWTGSGRLLDESLEGAELIFDPDGCMEMSAGGNGPNPARNRKYRCKQCGYVAMDKHDFWEHSKDHIKSDRMLACPKCNFVTEYKHHLEYHLRNHFGSKPFKCAKCNYSCVNKSMLNSHMKSHSNIYQYRCDDCTYATKYCHSLKLHLRKYKHQPATVLNLDGTPNPYPVIDVYGTRRGPRPKKPIASYTTSKSIRSKVIKKNNESNKCKVATQPKVDKLKNMATSSSSVDLNNKTRPLENTASQSINKSNDHHDNENDDNEQAQITYLRCNYCSFQTESKPEFSNHMLNHVVKEKLSLLNNKRKHLQQQQQHQSINDHSEDQKQPDQNGDKLVSNDLALDLSKQESQDQLQMKSSQDNPFSSLLQNFLEHQQQSQSEQADIRLPVTTTRQFIHKKRKGQARKLLPPSATTLDLISESESVSSLPSLSPSSFDSSPTPTKEPDDDEDESIRSDDIVVDEQMIDQDDHNMDDESQLSETSIMDDLPLLTNTSLTNDQIQLFDFYNHQQQQQQNGTDIQHPLPPTPIKSPEGDDQAMLMQLLSTSASNTCSATPSSSSSMSLSSSSSSSKINDSKAMAAIISKGVGSSASSSSSSSSCSKLPDAMTATTISSSSNGESIQSIDCLASCSTSNQEADTIATNLNSATAAAALALATTSSSTPNESLTNVNSLITKMHSVTFLMQEILLEMWSIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1A9</accession>
    <name>A0A922L1A9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_014458</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Lysosome membrane</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
            <orientation evidence="9">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1A9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029382">
        <property type="entry name" value="NCU-G1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31981:SF1">
        <property type="entry name" value="GLYCOSYLATED LYSOSOMAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15065">
        <property type="entry name" value="NCU-G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036882352" evidence="12">
        <location>
            <begin position="21"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9493722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="388" mass="44072" checksum="2CFA2090BE6CEA19" modified="2023-02-22" version="1">MANRIFFVFIFAVFGTIVQSKRILFYEQNPGCNIVECNDTHVVHITSEVDDDKNQSTYHNLWIFTNDYKPTIILFETEPKAKLSIDWLKFFQHENNSIIFKNGSVLNINFTEPRDNQSSILAIFSNENSSIGNFRFHLKSSAHSGREQLLPKLIYSNAGNLLQFEINDLFIPESIKQNNTRLQLCANLTTILGGHRLNSQIEKFTGMDDEYTPGVFQRYLYQMETIDKVDNNNQTRSSFIGWKPVAYFDHKQQIATSLKVISPSIENMTTIPLSSSALNGYFQSPTSSYTINKLANFRFNSEDDNEFDLTINGTSIEFSLSLSLIALSETQFSTSMTIIIVCILIGFGLPFILLIGFIMFTMSKRLLSLFVGSGSNNYNLQHNSESSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1H2</accession>
    <name>A0A922L1H2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1H2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="250" mass="27678" checksum="1D917FE4D23B781E" modified="2023-02-22" version="1">MLKIYQPQSSLVITIWTKMIRLFLLITLLLSIITIVNGLQQSSTTVTSSSSDDDSDQMTDQMKQMRRNEVSKALLLLKKHSIVGSNAKIVLKNNGRHLLVDPSERIRIVSSHLSKKSSSSSSSSSPKSSKSFKSLNHKKESHNKIEKQRTKKSSRTNRKASTTNNASSSSSSSNSKDQLSKASRSIPSISVESVQRNIMRRAASKSPTVIDSLMGQHMLRDITKIVTTIIHNKQASSLVELSDLITETLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2K7</accession>
    <name>A0A922L2K7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TAF12</name>
        <name evidence="10" type="ORF">DERF_006948</name>
        <name evidence="9" type="ORF">HUG17_1465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2K7"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="8">
        <location>
            <begin position="185"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7645927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9516193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="340" mass="36289" checksum="9FAEF95532C16E10" modified="2023-02-22" version="1">MSSSHQNDGAQANANIPISVSLNPGVGLRQSTHQQPAGATTFILNPSPSTTTAAAHQQSTMIHSGNFGYQQQQQQPPINSMIGAPIMNTQQPQFHPNQSQPMVMVKTEILANQNNTGSFTTMPPVTTAALLQQTNTFTAKSSVATPNGQQKIDNEAIDKNNKSIQNNESKSPVPPPPPPVVALDKQRLKELVEQVDPNEQLEEEVEDVLLSLADDFIESLVSQACMLAKHRKSNHLDVKDVQLALDMNWNMWIPGFGVDGVVGVYSGGAGSSSSSNVGQQQQQQISAAGSGTPHISGSNSVGSGNSAVAGMAMNRGPKKCLITEAHKQRLALIKKVMKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L306</accession>
    <name>A0A922L306_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ molecular chaperone y domain, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dnajc4_1</name>
        <name evidence="3" type="ORF">DERF_007331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L306"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052763">
        <property type="entry name" value="DnaJ_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="51"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9516598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="269" mass="32264" checksum="AE481F2E8019009F" modified="2023-02-22" version="1">MSFFVTNVGENFIKILSPYLNSHCCLTTGHYHARSLWTTKPFHYVQKQQENYYDILGLKRDCSQDQIRTAYLDLCKKFHPDKSAKNNASEQQIIKDTARFQKINEAYNCLCKADTRNQYDLSLNFGLGDNPFIKRPTKGYYYHHPPPMNHNDPYHHRYYNHQSPFSDRATYNYYNHIRRETMRQEHERYSQFHREMFGSKFTGFMLLTLVITTILQIRFYILWKESVKNRRSIIMEDLNNTISATNKHGLRSRIHLQRNVIDQKQDKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L473</accession>
    <name>A0A922L473_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L473"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="105" mass="11247" checksum="84A36E09F5951AA8" modified="2023-02-22" version="1">MRTADADADAAANGAKITSPINQNSGDSIDQSFEQYQKSLQQQQQQQQRNSSTGTTASNNNNNTQNSTAQSPTKYLFSAITGASNNNNNNNTVVVLPLVKQILVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4Y2</accession>
    <name>A0A922L4Y2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008610</name>
        <name evidence="2" type="ORF">HUG17_2687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4Y2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7638654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9518006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="255" mass="30486" checksum="6D1F81B6AD280CDC" modified="2023-02-22" version="1">MNSVLMNGRQTRQRIKKLIENYDKKIHDDHHHDDDAMATFGLNYFHPEQRTKMMKILLKYSIQIDELIVDIDLVEKNASWLNDIFLLNKRIINHIELLESIDLPIGDDKCDELCIDFRNQMLMRLTKLQRKMIWTFVKFLKHIIDTKLERNQLTNQTLLNNVVEYLDNVLQERIRPNFEFIIDIWNQIFDNDDSELNESNHDDSKMSELSDCYISASSSPSLDSIMNYDDNDDEREFSQKFSWPSEDDGMDFEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5D7</accession>
    <name>A0A922L5D7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5D7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8270" checksum="DDA716ABC26AADF2" modified="2023-02-22" version="1">MATTASMCLEFASITHSPYSVNFIRYIEAKACACFTIIIINQPVFVYKSDRVHKLVRIKIMLIMVDIIFQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L619</accession>
    <name>A0A922L619_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adapter molecule crk-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_005302</name>
        <name evidence="8" type="ORF">HUG17_3653</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L619"/>
    <dbReference type="OrthoDB" id="9204160at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11758">
        <property type="entry name" value="SH3_CRK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035457">
        <property type="entry name" value="CRK_SH3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="12"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="106"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="296"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7639620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9521666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="359" mass="41260" checksum="3E6FF1D73B585365" modified="2023-02-22" version="1">MTTFDPYDQNSWFFGQLTRNQAIEILEFERDKGVFLVRYSHSVAGDLVLSVSEENKISHYIINKIDVNGESKFKIGENTFHDMPSLLTYYKHHYLDTTALIRAAKKKLEYVRAKFDFLGKDKEDLPFKKNEILTIISKEEDQWWRARNERGQIGSIPVPYVESIDEEEYLSEKEKFDESSSEFDGKNITNINSINDMMMTNNHHHNNRHSNELSSLEPPPTLSSSASSSLSTTTTSMMDPSLNTNNSNLVPIQQESSLLLSSTNNDSNQKIDNQQQQQTNISFNNNKKSTTNMNRKLPAKAIVIQQRIPNAYDKKALKLEKGDIITVTNTNLNGQWEGELNGRQGHFPFNYIKFLDEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L627</accession>
    <name>A0A922L627_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Intraflagellar transport protein 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">IFT52</name>
        <name evidence="4" type="ORF">DERF_007513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L627"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23683">
        <property type="entry name" value="IFT52_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039975">
        <property type="entry name" value="IFT52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055460">
        <property type="entry name" value="IFT52_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055458">
        <property type="entry name" value="IFT52_GIFT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048643">
        <property type="entry name" value="Itf52_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969:SF7">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12969">
        <property type="entry name" value="NGD5/OSM-6/IFT52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23352">
        <property type="entry name" value="IFT52_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23355">
        <property type="entry name" value="IFT52_GIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21178">
        <property type="entry name" value="Itf52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IFT52 GIFT" evidence="3">
        <location>
            <begin position="9"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="IFT52 central" evidence="2">
        <location>
            <begin position="275"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 52 C-terminal" evidence="1">
        <location>
            <begin position="366"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9516794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="436" mass="50218" checksum="D5AFE5C110B16EAA" modified="2023-02-22" version="1">MVTGNSQQILVDYSKRPDLNDQINGSIDIKFIIKRLKLKGWKININKESLTEDLINKHRILVLFMPQLKFADFEFTALKQYLENGDGKILVLLEEGGERKSSSNINYFIEEYGTSVNNDKVIRTSFYKYYNPKEVLIQDGVINRSLINHALQFNLIQSQNVSQSSLSYLYPFGATLNVAKPSLPVLSSGKTSFPPCRPTCSFYEHEGDNNREGGRMIIFGSGHGFTDKYINKENNVILFDLFLNYLQDKQFKLNMIDSLNPEINDYHVVPDLESLCNDPMLYLEESEELPIDYSTLFSRKIKKISNLSLATINGTFNELQIEKRTLQVIKPHFETPLPGLQPAVYMPIFRAHTKPELELFDLDNEFASVQSKLAKLANKCNNNDVEYFICESGLIFGLDMANLKEKNVCKHILYMVATFEYDYYDDDDDDDDNFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6K5</accession>
    <name>A0A922L6K5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6K5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7269" checksum="0F5918466AE8DDD8" modified="2023-02-22" version="1">MHRIAAIPQIIITQITKNNNHHVHLIILNQVITSPGLRRGKCIFGLYYMDRYCWSFISTTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7M0</accession>
    <name>A0A922L7M0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylulose kinase</fullName>
            <ecNumber evidence="4">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_000372</name>
        <name evidence="7" type="ORF">HUG17_8187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="4"/>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7M0"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000118">
        <property type="entry name" value="Xylulose kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="5">
        <location>
            <begin position="139"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="6">
        <location>
            <begin position="304"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7640718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9526271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="539" mass="60323" checksum="9F6E82BD5F61C611" modified="2023-02-22" version="1">MESIKQSNQKLWLGFDLSTQQLKSIAINEELIIVYEAFVHFDNDLPEFRTNGGIYSDAKAHTATAPVLMWIKAIDLILDRLRLNGLIDFGQVIGISGCGQQHGSVYWKHGSERILMNLDPTRFLHEQLNQCFTIKDSPIWIDSSTSVECKELEKSIGSAHRLAQLTGSRAYERFTGNQISKIIKHRYDAYSQTERISLVSSFLASLFIGRYAPIDLSDGSGMNLLDINRKQWSLDCIRAVSLNQENDLMKKLGHEVVPTTQLIGTISDYFVQRYGFDPDCYITAFTGDNSASLAGMCLGSNDIAVSLGTSDTIFFTLSSPKPSIEGHILCNPIDHNLYMGMIVSKNGSRTRRRIRDDCADSNWSKFNELLDSVPRGNFGNIGFYFDFQEISPTIIGDFRFNYYGNEVLNFAPEIEIRACVEGQFLRLKIHTENLGFKTDKSTRILATGGASTNPSIIKVLADVFNATVFTDSMPNSGALGSALLAKYSQEKSIKSFDEMVEKLRATFKIAAKPSLDANDIYSALAVKYRQLEDRLTRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7T4</accession>
    <name>A0A922L7T4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7T4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="101" mass="10858" checksum="DF041E2B7328109C" modified="2023-02-22" version="1">MYPSINVVTGDQPSIAGSSHNNTGQSVSSTIVSALSNHNLHRQQQPNLSPFSSSSISRLNSSPVSLMQITSQQQQQPQQRSTSTTIRKNSSINSTDSSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L828</accession>
    <name>A0A922L828_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L828"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="254" mass="30224" checksum="B79D6381D8B9DAEA" modified="2023-02-22" version="1">MEQRFNIYVDEFYEITEKFCCFVWAQCECELLVAHECNETFAYHLNYKMNNDFGSFCQPILTLDEYRLNKFFTKCFMFDTANSKNFWYWSGLGTIVILITEYSCPEILATIWKWFLTVSGGLASIPYLILSMMLIIDQIDCGRYPYKPVYGPPVECTMEQKEAFDYCEIKALRYYGTKIDDFYINSLGFCCFVWYTLQCEIDVSRGCNNTYAMELKQSTINRFESFCHDQPSYEQYTSIFRSCFWHKVGYTFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8I5</accession>
    <name>A0A922L8I5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8I5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="353" mass="40299" checksum="B71FEE7A65384A3F" modified="2023-02-22" version="1">MIRTRTKVLRKLTKFQMIKKSTPQSILKNNEKYEKEMMKSSSMTMKFIPISDTDTPSRHICCRCKHQRIVHNGVGSKKIQLQTTATRKDEEIIQSINDGKITLHSFLLLSPHIQGRIRREWLRRNNRNIAATVDAAAADGDDDDDDDNDGISPLIASNRSTSSTNMMLTNKLKFQKMLNLLDDHDSPITTSTATTTINNNNNKTYKKKSLEKTIKTRIPICKSRVMIKTKHQSIDDDQAQSKKIKPKLTITKKIIPKHSYNLRCIASRAPTANKNDNSSSITNADCRLPIVKTKYQRSTVKLPNIMTRIKVKNTNNHNTHTSTKMATTRSIVTRAKTKTTTTLLKRIKTRILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8P7</accession>
    <name>A0A922L8P7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RPL9</name>
        <name evidence="8" type="ORF">DERF_007995</name>
        <name evidence="7" type="ORF">HUG17_2280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8P7"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000005">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="6">
        <location>
            <begin position="96"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7646742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9517317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="187" mass="21220" checksum="7C0581956E4A355A" modified="2023-02-22" version="1">MKTIQASQIVTIPENVNVSVKNRIVRVKGPRGILIRQFKQQLDIAMVGKKKLRVQKWFGNRKELATVRTICSHIENMIVGVTKGYLYKMRTVYAHFPINVTTSEKNSVVEIRNFLGEKYIRRVEMASGVTCVNSTAQKDELILEGNDIEAVSRSAALIHQSTLVKNKDIRKFLDGIYVSEKTNVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8T1</accession>
    <name>A0A922L8T1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">ADP-ribosylation factor-like protein 8B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ARL8B</name>
        <name evidence="13" type="ORF">DERF_005550</name>
        <name evidence="12" type="ORF">HUG17_3472</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8T1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008089">
        <property type="term" value="P:anterograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000247">
        <property type="entry name" value="ADP-ribosylation factor-like GTPase 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7639439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9521937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="185" mass="21023" checksum="15EB4D5C4E7622C7" modified="2023-02-22" version="1">MFAIFQRFLDWLRSLFWKEELELTLVGLQYSGKSTFVSVIATGQFSEDMIPTVGFNMRKVTKGNVSIKIWDIGGQPRFRSMWEKYCRGVQAIIYMVDAADHSKIDASKTELHGLLSKPQLEGIPVLVLGNKKDLSGALDEKQLIDQMDLGSIPDREICCYSISCKDKTNIDITLQWLINHSKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9M4</accession>
    <name>A0A922L9M4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9M4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="8437" checksum="5CACAF5C586AA3EA" modified="2023-02-22" version="1">MGCRIRFLRFRRHQRNRSQSDLYYRLSMLCHLNYAIDFVLLDFRAQVRDDHFDYHHHHHHEVKIDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9P5</accession>
    <name>A0A922L9P5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L22, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MRPL22</name>
        <name evidence="7" type="ORF">DERF_001730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9P5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9527724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="233" mass="28233" checksum="1DC7983842A91267" modified="2023-02-22" version="1">MMMNNLIRSRIWPIYNQLYNARILLPNVGFPHQQQLFESTYSKYDTWTYQHDQEIHQDRLYPKPKRWPRYNEIIHSPEEGPVERYYCHHRENIKYSPKKMYFVASFIRGMSIDEAIKQLSYVKLKGGAIVKEILQEAQEIAVREHNFEFKSNMWIAESFCSKGVVYKGFRKHARMRFGEIRYFHCHYYVKLVEGEPPEHYYPSQGPYVDKMSIEQRLEQHVGKLRQRRIDFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA14</accession>
    <name>A0A922LA14_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA polymerase</fullName>
            <ecNumber evidence="14">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_002866</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="14"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA14"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF42">
        <property type="entry name" value="DNA POLYMERASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="9 14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="16">
        <location>
            <begin position="69"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="13">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9528956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="435" mass="50299" checksum="1B5DAD8A067C1BF2" modified="2023-02-22" version="1">MNFNIFSTGLYWTKIEKENLFRFFKFCHWTVYFHFADGIDTKNGSTCVNIEYDKNKFQFETNKYNMSDNPNKDICDMLIKLGEHERDVNGIIYKYHAYRKAAKALEAYGKRVESGAEAQKLSGIGPKIAAKINDFLQNGCDEDIQGSSKEIEQETSPTSERKSKKIKKDDKKDTSSNHHNNKSNIEASSTDDDLIEESFDKIYGMTKIDVMYLKIKGIKTIGDLRNNITIAELNEAQQICLEHYDDLRLKISRKEIKKFEKLISQSLKKLSNVNVEIEICGQFRRRIEECDKIDVLIIDMKTKSTDSDAERKLKKSMKIIGKTLLAEHIIKKSLALDGSYFAGIVNLEQSSPYRLMNLHVVPKDQYVGVLFHLTGSEQFWERIRLHCINQGFILSSRTLCRIGQTLVPGLPIKIKSEEELFDYIEYPYVEPKDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA75</accession>
    <name>A0A922LA75_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA75"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="132"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="329" mass="37618" checksum="5F25A817F81E5428" modified="2023-02-22" version="1">MRILEEIMKLEYVSRNVQGFINLFEGKVDEINKDQDSVVINDFLKALLLTAMDRKKFSHVIRSIQNDNKLDYDNLVQKLLQSETTEVPKIDTVCPVKKVKCFKCNKFGHYANKFKRLTVVYSGSNQKLNCCFILDSGASAHCCNNRDLFLNLIEDETVLSTISGQRYSAKSSVIKDYNLLCNTSGTIMFNFGNGYGCVQIEKVYFTPNFDLNVLSIPLLQKQGFAINFPANEKRCEVYRGNDRIIEVDQDNDLYYVKYTSVKDKIVCFTAHEKFGHPGKSIQKRLNINENESCKDCLENKMVSSPHKFKIGANITKKLEHVAPLVSKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAS5</accession>
    <name>A0A922LAS5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_001043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAS5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035498">
        <property type="term" value="P:carnosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9526992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="411" mass="48142" checksum="08C5F074D7CFA547" modified="2023-02-22" version="1">MSDDDHHHHHLDDDNNYESISDQIQSVSNETMLSEKENNESNNEDDTVVDEELEEQQHFFDIINTFRFYKSYNMKKVQKRIDFVGTMSTKYQQLLQNYSKHLTKVQHCIVHNYEIIKVIIGDAAKIFRNHVFLKDNRKESNHSLIMKLEKDLDISRIDSILNQIVREWCHEGATERESCFQPILNTIEEYFPSLVNRNQIRILVPGAGLGRLPYEIAKRGYSCQGNEFSLMMLFVANFILNKIDSTDMFTFYPWISHFSNNLQSDHQTIPIKFPDVNPATISKDVDFSMVAGSFTEIFNNQQQHKNDQFDCIVTCFFLDTAQNIINYVETIDNILKSDGGLWINFGPLLYHYADSSQDSSIEPSYEIVKEIIESFGFKFLQEKTNQTCYYTRNPNSLVSYEYHSIFFVCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB21</accession>
    <name>A0A922LB21_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB21"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="92" mass="10959" checksum="DFB1A5CA576351BE" modified="2023-02-22" version="1" fragment="single">DPTSNQRKLLYNPTMIKKLLYNFSSIDRKSRRRRHQCLDNSCNPYIGIYPLQFFDYYDVINVILTQPPLIISIKVKVEFHRKKSICNHSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBK5</accession>
    <name>A0A922LBK5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBK5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="147" mass="16914" checksum="CDB6FA9A8EC490E5" modified="2023-02-22" version="1">MKQKKSIFLSLLTLIIIIIIINIRSSISIVNNNNNHDHQNETLILKWCPAYCRCQQEPIKVAKKLPAIWLSSSTLSSKYQFEIKQQQQQQQKQSKIKDSIRFRIDCGHQKINDLKQLLLESNNSLIHNGNDDDGTILGQPIHVINSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBX1</accession>
    <name>A0A922LBX1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBX1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8917" checksum="0DC69E12C9611F39" modified="2023-02-22" version="1">MSKYTNHYGLPYNYFIFFLMNLMNRIKLKRMWNNFKQDILEQQQQPQFSWFNKNNVFIPLIIPIGYLLHNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCI5</accession>
    <name>A0A922LCI5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCI5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7854" checksum="9C5B45E116EB4BE8" modified="2023-02-22" version="1">MAISKLDDLFDFLPPLLLRLLTLLEFELSDNSIFDNRVFPLLIEIDSIIVFHQIIPSTSIRVTIQVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCL5</accession>
    <name>A0A922LCL5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCL5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="91" mass="10348" checksum="E727DF949E0AF445" modified="2023-02-22" version="1">MNKIESKSIIGDGCIMTILEHCVCLRFVHFTTTTTTTVKNPCGNARNPIECKLCLLCINLTRTTTTTTTKFKDYASFDRFAFVMNEREKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCU5</accession>
    <name>A0A922LCU5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="21">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">ATP2A2_1</name>
        <name evidence="23" type="ORF">DERF_004025</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Derf</strain>
            <tissue evidence="23">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Derf</strain>
            <tissue evidence="23">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="20">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18 21">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="21"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCU5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000143">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 21" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 21" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16 21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="833"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="927"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="955"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH9530202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1005" mass="110983" checksum="131A782BAAF2B6F2" modified="2023-02-22" version="1">MELAHTKTSQEVLDYFGADKERGLSLSQVKENQNKYGPNELPAEEGKSIWQLVLEQFDDLLVKILLLAAIISFILAFFEEDEDTITAFVEPFVILLILIANAVVGVWQERNAEDAIEALKEYEPEMGKVIRSDKQGVQKIRAKEIVPGDLVEVSVGDKVPADIRLIKIFSTTLRVDQSILTGESVSVIKHTDMIPDPRAVNQDKKNICFSGTNIAAGKAMGIVIATGLDTAIGKIRTEMAETEEVKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRFFLIKNAEGGNPELEEFEVTGSTYEPIGEVFQRGQRVKCSDFEAMFELATICVMCNDSSIDFNEYKQQFEKVGEATETALVVLAEKMNPWEFEKRGLSRRDAALVVNHNVKKMWNKEHTLEFSRDRKSMSSYCIPKANTKLGNDPKMFVKGAPEGVLDRCTHVRVGDRKVPMTAAIKNKILETTRAYGTGRDTLRCLGLATIDHPPKPEMMDLADSSKFAQYEQQMTLVGVVGMLDPPRREVLDAIQQCRKAGIRVIVITGDNKATAEAICRRIGVFGEDEDTTGKSYSGREFDDLSVSEQRAACRRSRLFSRVEPAHKSKIVEYLQADGEISAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMERPPRKANESLITGWLFFRYMAVAYVGFATVGAAAWWYMVAPDGPHLTYYQLSHHLQCITDPDNFRGVDCNIFHDPHPMTMALSVLVTIEMFNALNSLSENQSLFAMPPWTNVWLIAAITLSMTLHFVVLYVDILSVVFSLCPLTILEWWAVLKISFPVILLDEVLKYFARNFIDVTASTDSGSKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-07-10" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A5X5X4</accession>
    <name>A5X5X4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Allergen</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NPC2_7</name>
        <name evidence="11" type="ORF">DERF_011017</name>
        <name evidence="10" type="ORF">HUG17_5823</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2006-05" db="EMBL/GenBank/DDBJ databases">
            <title>Cloning and characterization of a new allergen from Dermatophagoides farinae.</title>
            <authorList>
                <person name="Reginald K."/>
                <person name="Tan C.L."/>
                <person name="Chew F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2006-06" db="EMBL/GenBank/DDBJ databases">
            <title>Characterization of a new allergen from Dermatophagoides farinae.</title>
            <authorList>
                <person name="Reginald K."/>
                <person name="Tan C.L."/>
                <person name="Chew F.T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="5">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="6">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="DQ643992">
        <property type="protein sequence ID" value="ABG35122.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ677263">
        <property type="protein sequence ID" value="ABG76195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A5X5X4"/>
    <dbReference type="SMR" id="A5X5X4"/>
    <dbReference type="Allergome" id="3614">
        <property type="allergen name" value="Der f 22"/>
    </dbReference>
    <dbReference type="Allergome" id="3615">
        <property type="allergen name" value="Der f 22.0101"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6349224at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000001">
        <property type="entry name" value="NPC intracellular cholesterol transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007635503" evidence="6">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="7">
        <location>
            <begin position="27"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABG35122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABG76195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7643461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9506275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="155" mass="16896" checksum="6FAFA6DCAF5864DB" modified="2007-07-10" version="1">MNRFLIVCMALFCLAAAVQADETNVQYKDCGHNEIKSFFVTGGNPNQKSCVIHKHSKNQLRISFVANENTGNKINTRFICNLGGIELGWPGIDGTDACQGHGLSCPLTKGQTYNYHLDFNLGDDVPTANVTATVRLENGHGGDLLCGRMHISLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HFL8</accession>
    <name>A0A922HFL8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Negative regulation of GTP binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ARHGAP18_1</name>
        <name evidence="4" type="ORF">DERF_015909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HFL8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF1">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN CONUNDRUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="401"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9491177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="713" mass="80901" checksum="599225AE52CB8302" modified="2023-02-22" version="1">MFDSSSSSSSMKINTANNLARITYIDDDSSYDDDDDGVDICIDSLDLNVFDIDNDGKTLLENNKTIKKLNVFKNDDYSDDDDDNEIEKLPVINEDPLEQQQQQPFQQNPQLCINNDRMIITTATNVSSPSINDDDVNSMQTSSSKLMGKKRISSKLNSNAHRLRRFFIGNGPRSSSISNHVSNNDGRSVRIKYFKYNASYRKAQRGKHRQPIIYQLLEPIPVRKEEFPSSIININNNNNNNNNHGHQQKIDQSKSSKMPTNQFLMEQASLIYEDFGVQFINRNHKYLIAVSLALEVEMFVVVLELAFQQQQSLTYCEDFTKNLAGTVQELALRVLQTDVNRLQQQLFRLSPLSMNCESINIVADTNSSSYIIPMPNFSKNRKTFPSLISKNENRSIIIFGGNLTTLHVRDNERNKKDLDVPSILKHMIDYLGDNGVQEEGIFRVPGTKNRLNKLEEELTDLYMNYYKLNKPDNSKEINTIFERYNVHDVASLLKLFIRRLSPPLLTNELMDIFLMVPKIPNIFVSIKILNLLMLTLNDTHRNSLNALLILSNKVVRFMNYNLISLDGIATLLAANLFDCGSLSYNRNNPNQTSPAMNGVNQKRPSISTATTTTIESMMIGSPIQGAGGGGVGVGGSPKQSSIDHHRTSVSSQLVNEISMEMATQLERTQNSLFVLKLLINLQPILFHLPPYLERQIHEKVEEKKVQINQLFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HG01</accession>
    <name>A0A922HG01_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PiggyBac transposable element-derived protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HG01"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052638">
        <property type="entry name" value="PiggyBac_TE-derived"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47055:SF3">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="1">
        <location>
            <begin position="121"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="588" mass="69327" checksum="4308ABEE8C835503" modified="2023-02-22" version="1">MPRKQVKSLKHLREIINSQNWINNIDSDENECLDIVELPPNQVDQLSDLEDLDDDIINDEEPDDVPGDIEIHYQQKKKKSTKNNSFVSKWQKIEPKYSKTYPTVEIQERKNRLIEELKGKTPVECFEKLFDEFIISDIVKHSLIYSRQNNDHNFHVSNECIKKFIGILLFSGYHSVPQERLYWSEDEDFDINFIRKCMTRNRYMEIKKYIHFSDNSELLSIPSEERDKLFKIRPLLEKLNQNFLKFGVFSKFLSIDEQMVRYFGHHYLKQFIRAKPIRFGFKQWAICCSETGYCYRMDVYEGKSTTNTKETGVTGLGASVVAKMVSILDQPEQHEIFFDSFFTGFSLMKYLNDINVRATGTCRFDRMNKCPLTKDKEMKKKSRGTYDYQFDTKNEILAITWMDNSCVKLLSNHETIEPLSWAKRWSRSEKKEITISQPKLINQYNKYMGGVDKMDWNVQKYRIKIRGKKWYFPLVTNAIDVALVNSYVLYCMANDQISLLDYRRTVARAYLTLSSDLSDPKQQGRKALPKSSLTRVPVDIRLSGNHVIERTEMGRQRKCAICKANARKECKKCNVGLHMECFIKWHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HH81</accession>
    <name>A0A922HH81_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HH81"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="115" mass="13286" checksum="3C03F71C0A8A8652" modified="2023-02-22" version="1">MDRRVRELGLSLEFDWNLNPTILHVWSHVFVEWPVVSPGRHGHACLEHGNFLFPDALSLQQSAHPGGQDRPIGIDPLNRHRWPYPNRVEDLCAALEVRAWSDRKTKQFGHLPPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HHR7</accession>
    <name>A0A922HHR7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HHR7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="458" mass="52323" checksum="FB33C642639EA5A9" modified="2023-02-22" version="1">MNKKTSSYLDDDDDGDDDDCNDNGQIKKFYNNNKTTILSNNVIALQSQNDDDNQIDYNHNNHKDGNDLDANVKKTSNNNLDDNDNNRQRQQLRQSLSKNQKKKKKVKKLNNFVDKFWNRMRPIVPTPVIINASPPPASSSSSSSPSSHLRTATAVKNESEFFSQNSNNDPGKRNGISTIQNGGDGGNAENFYDAIDCAMMPSPSSSSPSLLKKSSSIKKYSQNDHTSRMEYIKQRNELEKLRFLLSQTSSPTSKYQTLFDNDFQTIKNGQHQHQDEQKQQTDKNGNRKDLDCIQPNTVKKFVNLFETKFGDTTGDGHHQQQKSTNSSSSLLFRRKICQRSLSSSSSLLLLLKCEPKQRNNDGKIMMNNYDNNDDDDAEYKKLFANFDETNILKSESNIDDIQQQQQQKQQCNVSYSSPIVHIYMHTRSSFDDLLNVVAIYHFHHRFKSHTKSFHSDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HK22</accession>
    <name>A0A922HK22_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_015865</name>
        <name evidence="13" type="ORF">HUG17_3852</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HK22"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000011">
        <property type="entry name" value="small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7639819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9491130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="88" mass="9853" checksum="2A430570FFF126DF" modified="2023-02-22" version="1">MAQTLPLNPKPFLNGLTGKPIIVKLKWGMEYKGFLVSVDAYMNLQLANTEEYIDGACTGNLGEVLVRCNNVLYIRGLEEEEEDGEMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKU4</accession>
    <name>A0A922HKU4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKU4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="189" mass="21675" checksum="8EB4C8C14B9F7858" modified="2023-02-22" version="1">MESVVIQLFEQLLVLSQQRINDWSKIDQLQGLWNTYRLSCLDPSYDGLELFLHEFQSKIDELDEQLKNGEQIESLSMLDKIIEKLNLDIDDSDEKIRLTMQNCQMDKLVRKKIIRFLKQKYKSSNFTIDNETSTMSTTTTIDGQESETQITPNPSAPPLTTTIEIVESNPIVQMDSPPPSPLAITDHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HME8</accession>
    <name>A0A922HME8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HME8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7328" checksum="4AD9722992C47798" modified="2023-02-22" version="1">MPELLLSMEFSFLSSSSLPSSSIWNFHLYRFIDMSFTANIIKRISSKKKEKKMKPTSADYCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNA9</accession>
    <name>A0A922HNA9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal 40S subunit protein S27A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Ubiquitin-40s ribosomal protein s27a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RPS27A</name>
        <name evidence="9" type="ORF">DERF_014081</name>
        <name evidence="8" type="ORF">HUG17_4027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNA9"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7639994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9493325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="155" mass="17359" checksum="A0B7613E28DBEB0E" modified="2023-02-22" version="1">MHLFVKGLSGTLILSAKPTDTVARIKSIIEISEGVEAIKQRLSYGGQPLEDSETLESYGIENDSTIFVTLGLLGGAKKRKKKNYTTPKKNKHKKKKVKLAVLKFYKVDDNGKITRLRRECENKECGAGVFMANHADRHYCGRCGLTLVYNKPEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNJ1</accession>
    <name>A0A922HNJ1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9496955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNJ1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9496955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="476" mass="55031" checksum="2B423D5F7B99B34F" modified="2023-02-22" version="1">MASKLIFLLVIFSFVVPIFGYHYKIKFFHPSYGNEDLLKDFRQDFMIKQKFVYGPMYHLKRLCHDTMDQRKNGIEKINSIYGIVSKRDGDVNQLIVEARKIIIHEAESDVFKYFGKKIDEIKWNNTINLNKVLRYEFGCKKDEFMIIEKCQYMGNNEISLVLKKTSISKNLISLFDKDPSSGERLNKKILFPKIRVSTILPISSPTTSTITTMSSSSTTTTTLSSITTTTSSSTTTTTSTTTTTRKPNMSTKLSKIKSNFQNDKILDEKNISNLKPKCGYPKIFFHSNEMTMQSDGVMNNYDIDKNVLDWNVLMKELVSEIGKVMKENTNEIKAEMIAERKIIINNDNRIGYWSITLDILINLLATIPFFLIGKFYKLIDKNNEEMKEQERKCNDDPLVILEIEDEGSESSSIRKYVSLHKEQTNIELQFEDEINPPDILDQTVSISYENDTFKLTKIENVFNGFKPIKKIEKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPA5</accession>
    <name>A0A922HPA5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_014519</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPA5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="14">
        <location>
            <begin position="95"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9493790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="362" mass="41867" checksum="3F05C4FAA0E7E2E4" modified="2023-02-22" version="1" fragment="single">QQQQQQQQQTNKNSSTIMGFTRTELKSTITDTDDNLVAEKDVISAVATVDPDEFDWRKQQLKWQNILLLGIWHIAAIGFYVYACIYSFKLQTVYLAVAIGMMSGIGTSAGSHRLWSHRAYKARWPLKIWLLIFQAMTMNGSALSYARDHRTHHKYSDTAGDPKNPTRGLFYSHIGWWLVKKTDAVIDGGRQLDFTDLYNEHPWISFGLVVVIRIVIVLHHLFTVNSLAHFFGYRPYDFRIRPADHRFVNYISFGEGIHNYHHVFPFDFRINERSQWELFNPPGMFIELNRLFGLAYDCKVASQSVINGVVRRRGVQPIRDEQKNLLFRIGNSIFDWTIGMLVGAWAAYPMIIFKLLTGRTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ46</accession>
    <name>A0A922HQ46_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_014992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ46"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="604"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9494296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="698" mass="79651" checksum="885CB75BC877283C" modified="2023-02-22" version="1">MDDEDVLKMLIEDGYDDDDDINFEIDSEAERRLLEGDTISSVNSSPTTEIDKDIKCEKNSSSNQSIEIAYHLKSNQSTNDGDTKNQTESNQNRQLLKRPYNDLSSNGNNSNVNNNSRNQSRFKRPRYPNKNSSINIQNEFFNIGKNMAFRFPSRRPSNSSTVQKSGPIYRFPSTTPSPSLLPRPQPLSNMPIDPILSADFFNNQNNDNFFQRPFSSCNSVMSPGYNGFPSAIIPNPFNPPPINIMPFLTNRSPFINDHQTPNESYIGFPTSNVFLEFFLRKNYLFFSKFFHKFITQPPLISNNNIQNPRFNFPDHSNRHFNHNINNSIHPITTSSNHHGNSLLPDPPLLRPVRNLTVLNQSNFQSKPNNQQQKRPNFLHTSNNASNVNNNPKIMINNQKTNVIKTSVQNQNLKSLTSDNSYNETLTNPSTNCMPKSTTSNQYHLSIAATITTKETSTTKDQRSKPILRKKKKKEVNKQTQPKQNQIVIAEKVEEIKGSFGIDEEYMRKMEEQKRLREKIAQEKAEKRKIFQTVCSGQTISSQHSSGNINSKNLEQSTINPQIMQIKNVSPIKTPTPIAKTSSLDKTATSKTTAQTIKPSTSIQISGLAIDVRESLLRKITRPFGMVESIVFIEQQQQQNHHESKCAIVKFKQSNDAKKFMDNCHTDPTILTQTLMSDKLPTLSFINNNWFVFNFFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQB0</accession>
    <name>A0A922HQB0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DCTN6</name>
        <name evidence="8" type="ORF">DERF_013795</name>
        <name evidence="7" type="ORF">HUG17_0883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQB0"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04646">
        <property type="entry name" value="LbH_Dynactin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7645345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9497840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="189" mass="20996" checksum="D33C37675414DEED" modified="2023-02-22" version="1">MSINKETVKISYSSIICTEHTRIEGDVIIGMKNVIHPTAKIIAKCGPIIIGDYNLIEENVCIINQTPGHTMTIGNHNVFEVGSNISTLQIGDHNVMESKCNVGLRTRITNGCVIGAMCTINYDEILPENTVIYGTRCERRLQQEKPSIQLSQIEFLGKILPNYQRIEKPNYRLPTTIQSSSTTTTTNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQX6</accession>
    <name>A0A922HQX6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TIMM10</name>
        <name evidence="16" type="ORF">DERF_013786</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQX6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9497831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="99" mass="11511" checksum="D10FC8201999AA2C" modified="2023-02-22" version="1">MATPQFNLDPSKMQIINELEVEMVADMYNRMTRACRLKCIVRKYKDSELSKGESVCIDRCVAKYLDIHDKIGKKLNSLSRMDEEAAKKLQLEQQVQQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRN8</accession>
    <name>A0A922HRN8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_013682</name>
        <name evidence="10" type="ORF">HUG17_0969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRN8"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7645431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9497719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="470" mass="52041" checksum="A3604ADBB7C949C1" modified="2023-02-22" version="1">MSMLCRRLFQVNTTNGLPAACVNYASARFVSNPSESTDLKGIMAKKIVEHQRRVKEFRAAFGNNVIGEIAIDQVYGGMRGLKALVTETSYLDPETGISFRGYSIPECREKLPQAPGGEEPLPEGLYWLLLTGDIPNKQQVETISKQFAAHADLPSHVVTMLNNFPSNLHPMSQFSAAITACNTESLFAKAYGEGVNKATYWEYVYEDAIRLIAKLPTIAATIYRNLYRDGSSIGAIDPNKDWSANFTTMLGFNDQVFTDLMRLYLTIHSDHEGGNVSAHAVHLVGSALSDPYLSFAAGMNGLAGPLHGLANQEVLVWLTKLQKELGDNVSDEKMSEFVWKTLKSGQVVPGYGHAVLRKTDPRYTVQREFALKHLPDYPMFKLVAQIYKTVPPILLELGKVKNPWPNVDAHSGVLLQYYGLKEMQYYTVLFGVSRALGVMASLVWDRALGLPIERPKSMTTEGLQKLVGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSC4</accession>
    <name>A0A922HSC4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSC4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="75" mass="9235" checksum="E20B56F61469BED0" modified="2023-02-22" version="1">MIIDIQQLKTNSTKRKKNETKRRNNEKKQHLKKEVGQKYLPEERNKEMSTGKKQKKTFDICNVRRRRRRRLFFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTX5</accession>
    <name>A0A922HTX5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ubiquitin conjugation factor E4 B</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase E4 B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin fusion degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">UBE4B</name>
        <name evidence="20" type="ORF">DERF_011097</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTX5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16658">
        <property type="entry name" value="RING-Ubox_UBE4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000060">
        <property type="entry name" value="ubiquitin conjugation factor E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="19">
        <location>
            <begin position="1138"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1202"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="1207"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH9506359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1229" mass="143029" checksum="771F5076E58E33A2" modified="2023-02-22" version="1">MDQSNDQSPSPSNVPGNSSGENDNPIINSEISSSSTSSHLANTIMPEIYVPQTSRELTPEELRRKRLSRLAGAGAYHNNNNNPAGQQQQQQQRHQVQSSINVAASSTIMTTSANLLPQLAESSLLQQQQPLNCNSSTKTTANNNKKRNDTLNHHLHQQQGVNNPANTEQGNESSLKYNVNLDFVSDKRSSSYPEPPSAMDVDCTPHNDKMNPNIGGSDARIEKMDVDNIEERRENLKRQRDNSFESKSDIVLDSFEESNSLSLTIFNIISKTFNVEISNENNGNNDQLIHSPVTINLQEFKTKIKPTDDYKNIIQFILMEIVTNLINQPVSFDDSLAYFNKFKPENFESIIQSTFKIKKNNDFEAVNFMSYRNKYILALSYVLDSFNRANKEEKLTLEKYETPIIRDLLASIKNQCINFVALIMNQSESDSYLINYFLQLLYSQKLHPDFINSFIVNTYNHYSPTLFAAIFEPILQNLWLDMNSYCSFIYDNHKLPLQILNQICNVSVGKSNYPIGELLTNSQTINWLLPATISESNGREFSKIAYMSPFLRLSVFAEDDPKIVDKYYPSKNGHDVVKQTTIDLQNTLDYIRRDLLYPIFHSLLLNHKSRARTVEFFTEALLRNSTRSRLHLDEKSVASDGFFTNLTSVLQLLSVKIKREKIDPLFPMNQNNPLAIKKDDSRIKFNQAEAEKWLEQEMAKPDFAWNEVTFSTQCFFQTLYAHHISVIPCIRKHMRRLRTIRELNRFIEAHQTDQSNRLRRYKEQMLRYHKSKLCAEAGLLDERFLGRCMIFYNQFIHFLLKLINCDNEYDLELPLPQNVPPIFASYPDWYLEDLADFLIFIIQHCSTILEPPNPYYDSANFECLILFIIVVISDQYLVRALMKFYTDVEITGTSNEFYDKFTIRYHISIIFKSFWTNQKQQFAIINEADNGKNFVKFINMLMNDTTFLLDEALVSLKRIHEIKEDMKNPENWNRQTREQRETRERQLAFDERQCRSFLILAVENVDMLHYLTKTVQKPFEAVELIDRLAAMLNFNLQQLCGKKCKSLKVPNPEKYGWDPKYLLDKITDIYLHLKSKKFYQAIANDERSYSHELFKDAASKMERIHIKSQHKIESFLLIISEVEKILEVKKQMEIDFSDAPENYKDPLMDTIMDDPVILPSGNIMDRSVIIRHLLNASTDPFNRQPLNEDMLVPNDKLRQEIKEWKQQKIRNAKHEKKNAETDTDETEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUF7</accession>
    <name>A0A922HUF7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Paf1 complex component, variant 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Rna polymerase-associated protein leo1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LEO1</name>
        <name evidence="3" type="ORF">DERF_011380</name>
        <name evidence="2" type="ORF">HUG17_10661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000006">
        <property type="protein sequence ID" value="KAH7640181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUF7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7640181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="549" mass="62521" checksum="576C750CC62AAF9A" modified="2023-02-22" version="1">MSDYRNYSSDDGSCDDIGLPKTPGAPLNANHSDSEKDEESNHSNQNDDSDVASNSGQSDDEEVNRSDEPNDDDSNAENYSSDKKSISSRDESEAEQKSSESDSDNDEKSPIDSKRDKVSEDDDDDDGHSNESSGRRKRRSSSSEESDQEEEEQTNKVTKKRKSVIDSSSDGDSGGDDDAKINKPNTEDLFGELSDEDDDQQTDRVSTNKQDEKSNLDDDEDDEGNEQNRYQSEIDTNINEIFGHGDDDERANNSMDEEQDVPIPETRIEVEIPRITANLGDSIHFVKLPNFLSIDTHPYDPQWYEDEIDEDEVHDDEGRARLKLKVENTIRWRNVTDDDCQMQSRESNARVVQWSDGSMSLHLGDEIFDIQTLNLLPGENNHLYIRQGTGLQGQSVFKTKLTFRPFSTESVTHRKLTMSLADRSQKTQKICVLPNVGKDPEAHRSEMIKKEEVKLKASIRKENKTKRVKDRTYTRGLSNPYLDHDDEDDESISIAKIKNQYKRGPNYPNTQFSDEEEESENDDSDLDIFEKKKSAEKRKIVFESDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWJ2</accession>
    <name>A0A922HWJ2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ORC4</name>
        <name evidence="5" type="ORF">DERF_011150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Interacts with POLQ.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWJ2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="160"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9506417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="585" mass="67844" checksum="A98E3E49836C711C" modified="2023-02-22" version="1">MGLVDDDEALFDNMIETRRRSCRILTKGLEASDETLTTPTNGRRRQQQQQQQMTKTKNNKDERSSKSKIAKKSKNETQNCNSNCNQKMNKKKKKKLSLNAVVDVEKPNDDKNLVNDNVTEKTHSSYCCIDDGGQNGLFNSYNDEIIYINKMIENLLKTSEANSLIVCGDAGVGKTKLIETCLTSFPVLSSSSSLSKSSSSSSSLNHHKNNDANFKVNNFNHLKVALFKFDGAIHGKDDLATIRLIGRCLNRFLDQQQQDSNDLDLTDDERDLMFDDLELSERVNNSIPKIMSQFRNLTENYQNFRSIIVLDNFDVFCRKQQTLLYNLLDLTQHGRSILVIGITRRLDYIELLEKRVRSRLTQRVVHLVSPFKQYDLYKTCCMSRIQRLCQENPTLETNFIANKSLIESELVRSFAINPNFNEINRIVFEYSFYHEPDDRNDNNFEMDNKENNKKTKLLSLITDPQIIAISRLKKNDLIFLMILLRHLRNEDVKIFTCADLFNWSIGCTLLRKTRMGLIIKSINNLINSDMIIFESDCYSRRKTSKQNIACVNKWTKLVPNVSEQHLEQFIKYFEHILPQAIKRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWM9</accession>
    <name>A0A922HWM9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Histone-Lysine N-Methyltransferase ash1l</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ASH1L_2</name>
        <name evidence="16" type="ORF">DERF_011207</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19174">
        <property type="entry name" value="SET_ASH1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000113">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46147">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE ASH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46147:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE ASH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AWS" evidence="15">
        <location>
            <begin position="2800"/>
            <end position="2851"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="12">
        <location>
            <begin position="2854"/>
            <end position="2970"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="13">
        <location>
            <begin position="2978"/>
            <end position="2994"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="14">
        <location>
            <begin position="3618"/>
            <end position="3739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
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            <begin position="169"/>
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            <begin position="270"/>
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            <begin position="582"/>
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            <begin position="2543"/>
            <end position="2554"/>
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            <end position="2586"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <end position="3794"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
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        <source>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9506477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="3859" mass="426396" checksum="9A773C989EA46420" modified="2023-02-22" version="1">MSSTLLTTEPDKSRQQQQQQQILVSTKDSNPKATLSTNHLINIAKTTLAAAAIGANNQQQQNLDTKNNKCDTSNNELSNNQEQSSKKRKNEKISKSKSLNSSTKDSIMSECNIVSSIVPGQGENGTSDLHHHHHHHHHRRHHQHHHHTVVQKTEKLIIETRKLSVVESTVQCTTTTTSPSHHHHHHGHHRRHHHKQNQHNRHNHYPRNNLRKGRHHRHHHKNHGHHHHHHHQKSKSLSSLKTNVLTTKTSTSSSSDLKCHHYKSLSMPISQTSTNSDLLSNNETGQQQQQIQSLKLSSSSSSKKSQKKKHSSQQQKQTLQNLQTISGDEISRKTKEAATELANETTINNRESSGFFEQPTTNCDSLSSSCSSSSNSSSKHSNGSSSSSSSSSTTSSSSSSSCSSDNSDEDDNDTNSKAIKEAQRSVKLKHCHHHHHHQKKKKKKTKSCSGSRSSKCSRNSSRSTSSSSGSSSLEESGDDDDDESKSCSSSNGSSSSSSSSSSTTTTSSSSFTSRSGSSCSQSSALSNNKGIEDVLTKISVAGMTIDNAISESLVEQQQQQQQQQTATTAFIHIFRGYHFATTTQQQQQQQQQQSSMKTTTTESSSSFQFQHSTMQQLAQTTETTNVQKLTKVNSTCSLSNPNTPDCSNSMIESPMSVDSQKYGISTTSTTSTSTTTTTTTTSMVKKRDPAEERQRLRSYRIAHHQQSQNRILPSQKSSTSTVCAVSCSISTLTTSTVSSSTSVNAVSNIKTSSSSSSSFSSSSSSSSSISTSTTTNLIQNTNSAISKSISTNNKTTMMAADSTSSETSSTTIMTTNNNNKKEQIQRTMVNKIVQQQQTVHQQQNLSNSIKSSSSSSSSKLLSSANILSSLASSSSTSATASVSTIANNANKFIQVTSQTAAAVAAGNNFLNPSFFLPGTTPTFSTGFHSAAANFPAFHSAFMPTIFNPQLSLNNIQLPVTATTASNNNNKTINPANTQFISNRQNPFFPLHANQSHHHQQQQQQQQSQLTIFTSPPLSTGSATAAAALSPFSFPAAMQHSTLLSNTPQFSPSSSATTAVSAATATAPLLMPKSTLNFPFPGTDPSSAAAAAAAAHSLMMFGLTSAKSSATGSLLSNTASSNAMTSTTTTTTSPPFILPRIVQTTSSQHNLTTANAANTTVIAKSLPQQHHNKSNKDKLLNIKQTTNSISSSIQDVTRTNFGTGPAITILPNTVSPNHPHHQAAHHSATNQQHSPLSTIISPQTLLLLQSPLQSSSSSSLSSSSAQVATNSFSNNNQLVHHYVQHSSSVASMITSNSTTKSLTTIKPSITTTTTTTATINIVGSQAAKMSQPSSSILTTTSATKTASASTAATIKPLTATNTNSLILAPNSALNPHLPYTLFSQPSPGLMQPISIQAPPPPAPSSVFGTPLLLSVISPTGRSGPPPHHHPQPHQQQQFHRSNLSSPVIIANAPTTTTTTTTATTPITLIQKNSESKNQNSIKSRQSELKNIQPKIEKLAPKTAQLSIKLPESKKSLSSSSTECNIPTTTSNIITSKTSTPVTVTTITSQQSQSLSSSSTNEISTNKPQQSSTQLQSDILVMKSPQSDEFESLVRSVKDTIDSFNAASSGLSDVDDNDNNNNSQQQQQQQHHSPKQQLKQSNKHTSLPPPPAPPPPVLKQHQTGDNLLKSSALDQPLVFPISTKQSPKTNDVKNIQKEMDRKPSAAPLQSKSIDDDGHQALVIGNDKTILDLEKKKNNHKEMTVIHNNNTNVGKSSKKKKHRKEKLRSSKSISSSANDYKKHKSKQNKKRNSSSSSNNNGKKGFSILSTGLDGGKNSSTSSLTTASLFDPILMNKIDSIIHWLKCLHLTGTNGPTIDHHALHPLFRQCTYTKSSIGKITKSSRLIASHHQRRSTNLTLKTITTATSNIGKDNNIIIINNGLNKNSSSDDNQRLLPLKKRQHRPDEQEPSSSSSSSSPNQFSSATSVSGGGGGGGKQKNKSKSKTANSSTSVDLITPSPPSTTVVNTSSKSVKSVGCGHPRPIIPAKIFPLLSSSIINNNNSYGSNIRKISKESVPPSNVPNMNKDNVAAENVTNSSSSSSSYKINKQRESKTTTTQPPLRQSSLDLELKLSKQHAIPNDTTTVLDKHVGSTISSSNRRSGTITTIMSQSNSSQAKRQQIQSSTTSIVATASSSLSSSSSSLSTEQKTAESIVDLLSNQQQQSIETGRIVGVGVTKRTKIQSTTRNNTAIYRDYIEQQPVSSSDKNYLVNNECDCQNVNDLKSSSLSKVTNVDLDEADADDEFDGTDDENENKTTTITNDDNDNRSNCGNKKKKKCETKRKQELQAKSVDKNLLKHEIKNTNINIKSKNIQHLFSTKDEDLNNSSENMSRQSINAAGGGGGGNNNRTSKLSSSATINETNTVKSKTQMNNKKSGLANNNKNKEIAQTANTTVVVVDTKKNDSKTNEAQKTIANNNKKKRRRVINKTGFTKPRKRNKTVVNTKNKNQNSMNPIMMAEVNDNETMMKKIVKSKSQTTKNKMKKSSESSLSSSSSSSSWSSSESDASKSNKKKSNKKNTKQKSSNFSDSDSTSIHSFPTGQSTTATTSSTSSQEDDDPDYPIYMVTAPSNKQNNRHKKVYPIKSNPFIRPIPSKKYYQAGLYSEEFIQLHSDEYFASKTNDNSTTTNNDNDRSFSNVLVKTDDDKSKTTTSTSESDDNNNRNDAQKSIDNKTWPKPILPFPPICLPSSFNSSKDGEIDSTKSKQHNNDSIPRKFLPQDPSFRQDFHLSFDIWYQYKYNPFPLLMSSANYRRVRQNVFVDVKPVATDSQQSCSCTMPRSPNESACGTDCINRMMYQECWPQTCPAKDKCSNQRIQRHHWSPGLERFMTRHRGWGIRTTEKIQKGEFILEYIGEIVSDRLFLKRMNERYNNDQHHYCLKIEPGVVIDGYRVGNEGRFVNHSCEPNCEMQKWAVNGYYRICMFALRDIESMEELFYDYNFHNFNVETKQICHCGSLKCRGFINGKNSLNPKLTGNSNEAAGSIQMDVDVASEEPTISTEETKPLIEFPYAFLKSYSRLPPNDPLGRSFLFVRRATKKIKVPVSIVKNGKNLRKQDIISQQENVVEISYDPIMLKRKMEPLSYTKKQKILKDLLFMRRNFEKTRRFYLALQNYLDNNQDNDQKNLYRIRYTSDNNGNGSDSESSTSRLLSSNCSIKTRGISRVGNDPNTKILKLTQIYSNICREIGLFILNKVYSTIFKGYHYDKNGIPKNGGEDYVNNDNNNHGAVKRKRNKINEHENAINNSLISFTPLIDQIRTGKLIQIDAFERNIISHIKEQLQEFRLDITNGNSKLKKLKLTKNGYNTATTTNGKRSKSPSESTNTLDNDDFTFIRISCDEIDSMESDAYKLLSDKLKEKHSIIKDIVDTENDSSAALCNGSKNIFGEKFKGTKLTEMNRKRMNKFIGVLESNEPIRISEHFSLPRIVESFIPKKLKKENDGNSETTSDSLIQQHLQIKEKNNEEVIRCICGILREEGQMIQCDKCEIWQHFDCVQQFSEVNLNENEYVCEVCQPRPVPKDIPLPNNLPNFDMPFPMNYYLTLESPIEKGLRIRLGDCVYIYRQSPNPVTSKQLSGKKNAEQQIDGEHFIETIRTAADNAIKTRSHPFERQQCIIIRVQHLAIIKNTGQRILFGHHYIWPSETYHEPTRKFYPNELLRSPLCEWAAMEEVRKTCMVLDPSTYTKGRPIGYDQKDVFICEMRVDRGAKSFSRIPKSAHFPVNIKSYAFEMYPEKLKIKRTYSPHQVPEPVAKKTKSNRKDNHHGNKFDENIDQQDDNTRSSTTSAIITKVPEIDEKTKKYKMIRLWKLTNKLNEQAYYQELLKEQQQQKPESEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX58</accession>
    <name>A0A922HX58_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX58"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="7558" checksum="AE9D5D7A7038CCAC" modified="2023-02-22" version="1">MVSLKAGMFLLSRCSFNSSQWMLEWMLLWLIFIWFMSTLSIYYDHNMDFSFGFFMLDMWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX93</accession>
    <name>A0A922HX93_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 4V2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CYP4V2_3</name>
        <name evidence="12" type="ORF">DERF_006985</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX93"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9516231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="535" mass="61617" checksum="4F6F61F0D28472E5" modified="2023-02-22" version="1">MYCILISTFSPLTLILSSVGIFMLITHIWQRYRRFRKIAKQIDQLPGPKVSSNLFGHLSLVWKSASHSANYLQQIFNLLVGITKIYQQEGEGFMRLWVGPTQPVVIIFNAECAEGILTSNSNIDKSREYDFAIPWLGLGLFTSTGDKWRLHRKMLTPAFHFRILESFIPIIQKQQAIMMKLIKERISDPKSNSIVDDIKPLITNCALDIICETAMGVSIDAQTDLTSKYSKSVRKVLDLFTQRLLSPWLWNEFFFGLSPTAREQRETIKFLHDFTNTVIQRKRKEIVDRMANGGGDLATTMNEIGTKRVLAFLDSLLTQNLRDPQSLTDEDIRSEVDTFMSAGQDTSSATVQFALQLIGHHPELQEKIHEELDTIYGDDADREIQFEDLRQMKYLEKCIKETLRIFPPVLFIARNIREEFQIKGQTLPIGTTVMVLFYQLHRDPKWFPNPEKFDPERFSFEQMNGRHAFSYTPFSAGPRNCIGQRFAMQTAKALLSSILRKYRIESMVPMEKVELAFGSTVGPKNKITLKFEPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXC8</accession>
    <name>A0A922HXC8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_009159</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXC8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.930">
        <property type="entry name" value="Mammalian shaker kv1.2 potassium channel- beta subunit complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9510642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="332" mass="36520" checksum="644B2D6EDE4AA23C" modified="2023-02-22" version="1">MVAPSKLEFTKDAINVIDAIATLSFYSDLILQSLAASVQLANADILDFFSIIRILRLFKLTRHSRGLKILVHTFRASAKELFLLVFFLVLGIVIFASLVYYAERLQANPRNDFKSIPEGLWWAIVTMTTVGYGDMVPQTYAGMLVGALCALAGVLTIALPVPVIVSNFTMFYSHTQAREKLPRQRRRVVNVADPIQPTSTTTSPAPPQSSTHHSWTNTAYNAINKQSSSSSSPPPPPLSSSLIKSNSTTTSITTTTTTSATTTFVTTMATTMITTTNNSLVAEKRRRRRSSQQQSNIKENKISELSYVKHDDATAITTADNNTVIHHHKGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXW1</accession>
    <name>A0A922HXW1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GOSR1</name>
        <name evidence="12" type="ORF">DERF_010078</name>
        <name evidence="11" type="ORF">HUG17_0117</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXW1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7644579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9511631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="270" mass="32004" checksum="667FCC71B07FF6E8" modified="2023-02-22" version="1">MTIDNNTNNNGPVKQWEELRRLARQYETDIDTKLVSLSKLMSLRNDRKYYPSSSSTKVAGVRFHQNKQQLQQQQQDDDEEPLISSKETFDHLTFEIDSLINTLQNVNSQMDQCIQQLPNNNSILYTLQRHQDILNDYRKEFYKLRTNIGEQLNRDLLFLKQNQTKNDYNNDDYHGQLNRKTDFLHKEHDHIRNSEIMIDDQINIAIRTRDTLRNQRSTMKAIQTQLTTLANKFPMINNVIHRIGIKKRKDSIILAIVIAICIFLLLLWIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ01</accession>
    <name>A0A922HZ01_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ01"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7569" checksum="BFE262EF25F7A139" modified="2023-02-22" version="1">MIIFKIDKKNNRNILMVILQCIDTNFLTSSQDLVTLIKFNRKICQIQDVCVLVSDSLSCLGHIQND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I057</accession>
    <name>A0A922I057_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NARS2</name>
        <name evidence="10" type="ORF">DERF_007338</name>
        <name evidence="9" type="ORF">HUG17_1746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I057"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="166"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7646208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9516607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="489" mass="57073" checksum="0423DFE916B69C8E" modified="2023-02-22" version="1">MILSINCIRFRFQQTFYICRKYCHNNIRSVETIKTILEHGQPSDVHRYKVYGWIRGKVQKKKTKWFLQLDDGSSAERLQIIIPASLMEQCDRSRIQNGASLECIGRLLKSLGHQQSLDFLCDQFTVIGECPPDDYQIAHLKTGMEFDLLREQIHLRPRVRYFQSILRIRNELSRAIHKFMADNQFIEVQVPLITANDCEGGGECFTLKPANWPITNPEKLYFDRPTYLTVSGQLHLEAMASSLSRVYCLSSVFRAEKSMSPKHLSEFLMLELEQAFLFDLKTLMSIVEKLFRYLLVEIEKNCPKDLELLLEKNQHHKYYDKLKSCKFLQISYGEACQMLSSKYPKLNADSIMNFNAEMERSLLEICDHQPIFVTNFPMEIKPFYMKTTDDGQMAECFDLLTPICGEVCGGSLRENRYDRLYEQIKLKNVIKNNANNNHQLEWYLDLRRFGSVPTGGFGFGFDRFLQTVCGVANIKDVVPFPRWPYHCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I058</accession>
    <name>A0A922I058_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_008545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I058"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="68"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9517929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="170" mass="19945" checksum="7B854A7973B346DB" modified="2023-02-22" version="1">MSSQMIRQLVPISRNLFTRRLLMPNVFIKRNFLPSRRGYDPFADIQRSFDSFFREMERSFFPTMNQLRTPLSRALPMETIEDGQRMFKIEIDLPDFKPENGEVKIDAKCEITDGSSKQFKQINYSYSLPDDVDLDRVRSLLKTDGRLVIEAPLPALEAPKENREIPIKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0H8</accession>
    <name>A0A922I0H8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="15">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PLCB2</name>
        <name evidence="23" type="ORF">DERF_007161</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Derf</strain>
            <tissue evidence="23">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Derf</strain>
            <tissue evidence="23">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 15 18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-(acyl)-sphingosylphosphoethanolamine = an N-(acyl)-sphingosyl-1,3-cyclic phosphate + ethanolamine</text>
            <dbReference type="Rhea" id="RHEA:60648"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:143891"/>
            <dbReference type="ChEBI" id="CHEBI:143892"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="17">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="15"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000084">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000005">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF149">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08703">
        <property type="entry name" value="PLC-beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 15 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15 18" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="22">
        <location>
            <begin position="633"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="752"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="495"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1227"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH9516422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1304" mass="150046" checksum="60F9DD5C982E22E0" modified="2023-02-22" version="1">MANAKSGVHVMQLKPISVPKSLIDGCKFVKWDEDTAIGVPVILKVDKKGFFLYWTDQNGETELLEISSIRDTRTGKYAKTPKNVCLFDIDFQHYNYNNDNDNQLQDGKLKESINIGPQEVTLEDKTLTVVYGTDFVNVNFINFCTYSKEIAQEWTNEILKIAYNLLAINASVYTFLEKAHTKLFLMSDRDRKLPVKYIMKMFANHKDDRKKIEKALESCSLSSAKNDTISLEKFDMNTFFDFYKYLIGRNEVLEIFEKICGDHTFGDIKVMTVEQFVQFLNKEQRDPRLNEILYPYANRSRGMDLIEQYEPDIQIAQKGFLSFDGFLRYLMSDDNAIIPSEKFDLNSDMDQPLSHYFINSSHNTYLTGHQLTGRSSVEIYRQCLLGGCRCIELDCWNGRSDDEPIITHGYTVVTDVPLKEVLEAIAESAFKTSHYPVILSFENHCSNKQQLAKMAKYCRQIFGEMLLTEPLPSHPLKPGVPLPSPNLLLKKIIIKDKKEHKHSRRKSKNMASNHEESNISTATSFDEVRPENTNQASIGGSNKQQNQQQQSSSSTSQQKTTDLETNVNENHSNDMNSSSDLTNKNYSCDMEDPESGDSSSDDDDVMNEEQSISTDLPVAKETTDSPFIYRSEMSQLVIYVQPIQFRAFDMAEKRNRSFEVSSFDETQSTSLLKEQPVDFVNYNKRQLSRIYPRGTRVNSSNFLPQVFWNSGCQMVALNFQTLDLGMQLNLGIFEYNGRNGYLLKPDFMRRQDRRFDPFTESTVDGIIAGTVSIKIISGQFLSDKRVGTYVEVDMYGLPADTVRRKRTKIVPNNALNPIYDEEPFVFKKVVLPDLACLRIAAFEENGKFLGTRILPFVGLRPGYRHISLRSESMQPVTLQTLFVHITVKDYIPDGLSELADALANPIAYQVEKHAKQLLSLIDEGDDVGEEPYDTTVNKPNLAYCSDSRCGEEITTMINRQSSQAEISLHSSLMMKGDSINKMELNGASKPSSKVCSPTHKMSLIRQDTLNRKMRIDDDLNVEKLSSSLESNTALLDAEPIEKLKKTKNIQKICTKIDRDILTLQKRFEKLREKIKENYIQEEDKLTPFSDKNKKLNNISKSVKKIGSRKQPSNSDGKISETEWKIKIKELQKTFSINIFNSFMEQYKEEFKAFENRYEQLCIALDKAMEDSQNSQKQYLTSLHDKEVAALMKRLDLQNKEELTVLSKCHKDKNELARIKRELQQKLIDQAVQERQRLQILLDKRKIELVEKHKKQERKLQEEKKRMLEEKQQECNQKSEHMQAQFNQCGESFFVKMFGIEECQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1E8</accession>
    <name>A0A922I1E8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor expression-enhancing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">REEP6</name>
        <name evidence="8" type="ORF">DERF_010480</name>
        <name evidence="7" type="ORF">HUG17_9880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1E8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7643189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9512071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="183" mass="21718" checksum="1AD000C723D11912" modified="2023-02-22" version="1">MAEIYQKTMDEVEKFLHQPGSKVDVYMEMIEKSTGIKRMYIAKGVMILFLLYMIFGYFAQLICNFVGFIYPAYVSIKALETRNKDDDTRWLTYWVVFAFFSVIEFFSDFIFSWFPFYWLAKVLFLVWCYLPIEKNGTDYVYNKILRPIFLKNNPGIDNLAKRVMNEAKAASKSLFTTNRCPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1P1</accession>
    <name>A0A922I1P1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004551</name>
        <name evidence="2" type="ORF">HUG17_0622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1P1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="16"/>
            <end position="49"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7645084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9520867.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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    </evidence>
    <sequence length="108" mass="12142" checksum="F55193D6DDA63A67" modified="2023-02-22" version="1">MVPKQRLNGNVMMQVAGNTQDDDNNDCNGGGGQFRVPKSIPHQRKETEPIMSNDGIVGIMRYGIAKNFNNSHLNKKIKSSPLLNQQRFPMKFQYYTKGSEFLGGPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I248</accession>
    <name>A0A922I248_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004533</name>
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    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I248"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="507"/>
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        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9520849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="582" mass="61161" checksum="BCCFAE4E162ECCA3" modified="2023-02-22" version="1">MAADSISTTTKNPVSPVSPMTVVAVSSSSPELNVNQQQQQQQQQQHQQQQQQQQQQPNDTSLMGTDDVSITSSMMDQMSPFSNEFRRRIEVAVAKAKHLQQQQQHQQQQQQQQKCGGEDVVGTTTSASSTSSSSTSSTNDNEAISSVTVTSGGGGGGGGERSIVTENNNGAGDNGIVVVHTSSESPMDQQSNDSSSSSSTTSMSGSSLASVLSNGSTTTTTRTTTTCNNNGNGNGDGDGQRNDAKSVLTLMMPSPSNHLLSSSNTPTSSTSNMMNTINGNNGSMLKGHHTHHHNHHGHHNHNHHNNHQLLNNNNQQQQQQQQHLHNQVMSPGVLSPTIAKWMSNHGTVPLSHHHHHDHHSSSPTVAAAAAAVLITGGGGGNHSHHPHPHPHGHHPQSHHLHHSSHHHHAHQHQSMIQSANMIHHGHVATGANINGSVGGGNIGSSGNSHSPLSINVSAHQMSEDASALSSKLIMASMAAANSHHNHHHQTSITSSCLGTATAAGFLPLTGAGPPPPPPPPPPQSLSSIVTSGGAGPNTSTAAGHLHHHHHHHHHHHGESTYLSPLDSAATKHHASNLSTQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I327</accession>
    <name>A0A922I327_DERFA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">DERF_004777</name>
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    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
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            <taxon>Pyroglyphidae</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I327"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="109" mass="13058" checksum="60257C3438E55579" modified="2023-02-22" version="1" fragment="single">MSNSDNEMFDGWMMNKYWPRLNWPIFPMLNTQIKFMESMNEIFNVVVTIANYGPQTTQTPRNIDILTISILNLKIKFHHHDDDGDLYYCLTNIFRYYSVVVYVYKNTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3I8</accession>
    <name>A0A922I3I8_DERFA</name>
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        <submittedName>
            <fullName evidence="5">Single-stranded DNA-binding protein 2</fullName>
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    </protein>
    <gene>
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        <name evidence="5" type="ORF">DERF_008576</name>
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    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3I8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008116">
        <property type="entry name" value="SSDP_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF12">
        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
        <property type="entry name" value="SINGLE STRANDED DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04503">
        <property type="entry name" value="SSDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01743">
        <property type="entry name" value="SSDNABINDING"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9517967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="287" mass="31673" checksum="CB7D5F0C32E1EE89" modified="2023-02-22" version="1">MYAKGKGTTVPSDAQAREKLALYVYEYLLHVGAQKAAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAKAFHDYGFVNSGYTVNGIAAHNPTAPSPLNQIPNDGMPGGPMPPAGFFTNSHMRPSPPQQPVSQPSPHSQPPPPPPHSQMMQNQQFMSPRYPPGGPRGPGGVRMPQQVDFNPSGGVPGQPLMPNNMDPSRQGEGDFVGWQPGPGGMNSMNPRLNHPRGQPMGPMAPGGYGRYETTTTKLNGSWTWTRWTNATRYGYATWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3P9</accession>
    <name>A0A922I3P9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3P9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7802" checksum="399768096FB79750" modified="2023-02-22" version="1">MPIQSMMIFRNNELEEIQMIAPKKGRFDQGRKDIDDIIKTIGDLVGDSIMVKKGQLLITPNEKQTKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3Q9</accession>
    <name>A0A922I3Q9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rapamycin-insensitive companion of mTOR-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_008579</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="4">
        <location>
            <begin position="90"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="3">
        <location>
            <begin position="729"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="5">
        <location>
            <begin position="1154"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1416"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1504"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1826"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1511"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1525"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1566"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1585"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1829"/>
            <end position="1851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9517973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2025" mass="228937" checksum="D9C21EFB5A3C3945" modified="2023-02-22" version="1">MIKINRSNRHWNRSQRRRYHENDFDIQFDWNRPLNQSCYVILYHISSKDSIKNKNKLLAYLNLFTKYCLYRYGKLDANEQATKHGQSSEISSSSFLCDTEILCCLRVGLFNEVAEVRAASLRAIRFFVQNRKTLHHLIDINLHHLIARSLDIVLENRIERIQAMRLLRHIMAIEPNIFPIALGRCLCSIAHDNYVEKDMLLRVCWATISELTIVNAVTSARSGCINILVRCALNAITGLNLSECDGDIYGGGGGGAGKNQRNTMNNPNNLVMSSGNGIVTNFTIPFTNIALSEVIISSFLYLYNYPETRRLLQPNGSDLFYFISPFTDLYSFFHASKAAQEQRNLNAIHLDDNNYDPHHPHHHDDRTKFPFDFDLPIKDNKPVHNVRIGLNKQKQQQQQQSNASYEQRTLRYLSCKNAILSILRSWPGCFFMCRVVKMNRFYNTTNRLEYNSEWVNMSRKLARIFFEEKKLSINDPTLKINGYDTLNPLESLVSLLHLPYTEIHRHLLELLYELFGLKLPECADDFDESIRCVYFNYQTRPQQQQQTSSRVAMQTNKNYLPDEWQLYDGFIAKEAEDILPSLAGGRLNFIINHQALLLQSLIEFGILEALLNVILESNDGATINLSTIMLGELLHLSGKYLPQSSYAHRCQSLPTLVAASVSNSRERRNRALMTMTTLNRIQDIKKQGPRPTSLFLEQQIFFYNSMNTSLPSSSNILVGRKKSGSISKMQDENVLLSIKNSYVLKKDSFRDWNWDLIIDIFKQPYDIMLKLDDKEVRSFCSRLLEFFSPSKRQFSSISKNSCLSSSSSSSTTSETMVTTPTTLKMMHGHNNEILYSENPRQICLAAIYFIDFLLQADENRASDYLNIFINDLDQCLKNIANKSPSSDEILIPSRLLSTLSQKYFLLLGRFTHYRLGRNWLKKTHIYQNLIDLIHISTNEIYAKLIISSFDYSEKDFPRNILSKVLTSSNESSRIYSTKLLRLLLQALDILDEACTENMNYLQKVLEHRPALQNLGDKGITNTLDRELDRWRNHFHLRYVRLVEDCLNECFTCHQKSVTGKYGRRPDRRNFSQLRCSSMTAHLVPHFYGQLAKTCEGLQIIIQHSLCEEMLTIIHTQMNRYICMMTAEQNDVINNNNNNDNYNENRDNNNSEYNILRMKAALWAIGHIGSTDIGLDYLIRCDGNILKSITMLVERSTLLSLRATGFYIICLFGSTLFGAKQLSRFGWSAIQHSHHDCFPIDQQHFENFHLFPMAAAAAVIRNQPIESNEMTTTNATVAAAAAAATTKSIISIPSGYFSLFVDNDNSTTTTTTNLLSSSQNTNNPLMNSNPCQFSISSNSSSSSSSYLSILPTTSGGQHTTTSIRNNKQIGSMEKLLKQQDLSSTLSSTSFGVESNTSSLASLSITNPYNTIMTINNNNKNNRLRSSSDCNSSTNHTTTNATTATNVSLFDKKKSKPECQDSGILNQSNDALNRSNMNVVTKHEQRNRKISAPCFPIVSSSSSSLMIMNNNNDDGHDDKIRHDSYESAPTNNSESRSASFTEYSTTSSQSNTLVRQPYDDTINDRNETSGNSLSPSSNVAIAQSQLTTTTTTTRPTPVPIITNNNNNNRQQTPIVIVNDDDPYPSPMDAYGYAQLIAIQKCRLQSLSGNMFFNHSGGGGGVGGVVVGSSSFSNNSIPDSFPKSIDSVNTDTFSIDLFQSKNSTNDTFQKLSNSTNARMSISPIQSKCIFSIDYTNPNHHSKLINNQLSITDSMVGSGINDGKQRSLSDSSQISGQSECEMIAENVSMNCQQWNEKSNFMCLCLPKNLSLIFHLEEVIVSLHNNNNNHRATTTKTTTTTTTTTKVKSSGPSMKTSSSNANHIAAKCLLCCKDFGIKITYPTLLINGKCEPPSSEVDMKSDSEMLTDVNNTNSLDLNVHRDEVLRLVSDLHVVMFAKQSEQGLLSLKQKFPKIFENFCLYSDVCLQMERNDYKATARRFLHELFMETNVDQFYQHADAIMKKYEHLKPIELSSSSLLSSSSTTTTTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I486</accession>
    <name>A0A922I486_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Voltage-dependent calcium channel subunit alpha-2/delta-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CACNA2D4_2</name>
        <name evidence="19" type="ORF">DERF_004598</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000007">
        <property type="entry name" value="Calcium voltage-gated channel auxiliary subunit alpha2delta 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF37">
        <property type="entry name" value="STOLID, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="3" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038077404" evidence="17">
        <location>
            <begin position="25"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="18">
        <location>
            <begin position="256"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="490"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9520918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1305" mass="151593" checksum="8EBF194ECAF94024" modified="2023-02-22" version="1">MNITVIIMMMIMIILQIMISGTKCAIDEFILDEEIIRNMVKTFGRELSSVGTEQTCLGRIEENFQRFNQEVQWFDGNKMMDDMRNDVMYMFNWKKHSVERIANESERIASNHTYDKNMEIDYYNVKGVEIKDNNHYLRSLDSGSRPIKLTRNTNFDNAYVNLDHSAIHVPVNVYDKSPDVVNDIKWSEHLTQFFKNNLAFDPSLSWQFFGSAKGFLRLYPATSWRERDSYSDKPLIDFYDCRMRPWYIKGAASPKDIVILLDTSGSMTGVRKSIGQNVVEYILDTLTDDDYVAALKFSKTVQPIHSCLDTLVQANRKNIKEIKQGLSDVKTNELVDFTAALSQAFTILQRFNRSGDGSQCNQAIMLITDGAPGTYEDVFRQFNWPNIPVRVFTYLIGQDVTSHSEVYWMACHNRGYYTHVMNRAEVHEQVQKYIPVMSRPIVLSGERVFSWTPIYAPTYETELNENTWKNKQNYEKINRLRAQARYAHEELDQSLNNADTDDDNDDIDETIDNTEESEDTLMTNNGNRKRKRHHQSIDDLAINENDDGNVVSIPYKQIPFRIQQQYQHQHQQQQQNQKNMKKKSVSLYTTLATPVFDTRNYTNITKRILIKNVYQDAEIETIRIANLLGVAGVDIPIKEIEKLTPSFKLGVNGYSFMITNNGYLLNHPDLRPLFDGFLKPFYHSVDMSEVELANNTLGPREPDPYIESIRGNMINRTHGWKKVAVKVHIDEMKRVITRVNHYTHGMIGHTPFSLAIALPEPYGSYRLTSQVDLRMKYREENFTHYFRGNQWRVHPEWAYCDNPHQITGQPQQSFSTPEESILQFLTNDLEKQNFRWRTSSIRPKVYETILCDKDLIQSLVLDANLTDIPTERCSSNPNYRDEQRIKTFGIVSTFVATRSGLTRFKDYRSKDEIKMLDDLPFYHKHDRAIEETYYKRTVDFYTNNKDAFVYFVDFDAGEQHERRVAATHSRYDSNFLVTATHALFIGNLKHSSPVAVVGIQFRYDTLHEFFLNTTNKFNVPCTHLDVDCYLIDNNAFIVLSNHKTNDVGKFFGQIDGDILEELVTSGIYQRVHLYDYQAICLDAEIVSGPSSNPYLYSIFALVAKMLKSFITWLGLLYMNILYGNDVWSMAEKTYNVRQDNWMEMGLPFGSEYTMITDLDDNQTIARPCDKEFDLYEMINFSTDGQSKDIVCGENPKCSRNFLAHYIPHTNLLLIISVNNPTCNCQKKKLSIEPIEIKYDDEKQCQLLKTEKYRRRPAGCYNYHPQEKEIRQCGRAYTLSSTTTWLLLLLLSSSSSLSLILSIDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4H1</accession>
    <name>A0A922I4H1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mpv17-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_007903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4H1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF8">
        <property type="entry name" value="MPV17-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9517220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="22084" checksum="03FD925C006C34B0" modified="2023-02-22" version="1">MLLRNISRVLYSPKYLFWTNTATGVLFFGTGDLMVQKFIDKRSKIDTNRNVNSCIAGIYMGSISHFWYGFLDRIFPGTNRKMIIKKLLSEAIIGPPFAASLFIVVGKLAHKSMEQIINDAKENFKYLLMADWCFYIPLQFFNFYYLPTKYRVLYVSMLSLVYDSILVYVLHRNNQQPTIPKKNIEMNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5D2</accession>
    <name>A0A922I5D2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5D2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9518266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="7534" checksum="939EECFCE7A5A138" modified="2023-02-22" version="1">MNNADNDVCSAGLTMTVLPAAKAGAAVFANINVGLFHGIMIAQTPNGIRMVIVIRSSPQAVGMVSPLILSTIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5Y5</accession>
    <name>A0A922I5Y5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5Y5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="312" mass="35629" checksum="7F4081ACFB55E192" modified="2023-02-22" version="1">MNDTITMINNECLMTNNHGNQQQQQQQSESDQCSLIENVIVGRSNEPISSTNNNHHQPLLIAMDMEYHHQQQQQQQFHHHHHHQQPSPHPHSFIVTNNGSNSTILPPSTAAQSSTATHHQQQQHLNGTYHHLHHHHHHQQQQQPTTVNGYYYHHHQQHPTSTITGAATTTLQPPPPPPPPSSSSSPQPPSTTHQQQPAPPPSSTTPQSSISECENEFIYESSSSSSSTTTASNSNYDNTSNYQSSTPTKQLDHTAAYNHQDPNVVTNGYHHHHHHHHHNHHHHHNHHHHQQQQQQQQQEMAEYHDVSSRFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6L2</accession>
    <name>A0A922I6L2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc-finger associated domain (Zf-AD)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ZKSCAN7_1</name>
        <name evidence="12" type="ORF">DERF_008846</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6L2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="502"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="616"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="408"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9518255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="708" mass="82307" checksum="6316EBCAEC551D80" modified="2023-02-22" version="1">MEESRNDLLKFFIQYNDESVPQIMQIPSQLSEKSSEKFIEQLKQFINLLLHFRYMSMYMKKHLDSMMDDKSVEPSTQLAKSLVYELSEDIQFCSEKFAQLIDSSSFFDFVHKRERFYLENMDSYFPFKRDNCQSGNKMTVFNEHHNQNDSIAVELIPNDIVVINHEHDSTHNSNDDSASILTDQSHHQINLLYSNPSQSSSSQPQDVHATLLDGLLSSADNQQHHSTDNLSQTQATKRPPNDDGDKRRQSKRSRSSTKVSTIEQEDDHSTGSIGTTATDLLLVEFHCQFEGCRYRSKSLSQVKDHENRRHVQQVQPCQYEGCKAVFNGKEELDSHMSNEHLNLKLQCEIDGCEQLFPNVSRLRQHIKDEHRPSTICTNPDDATDHFTCRNCGKSFARRKYLHKHIKRMHDNVEKASKKKSTTKGKKPKSVSEDLPYSPTSGSNEADDNDDDDDDDGDDHDHDDGGGSSNDKDDDTIEIGDDNCDNEKQELLSKSKKKSTSIFECSNESCAETFTEKSKLNQHVREKHRIEYLTCKFCDKLCPTRNSLTNHIWIMHEEGEYRCPFENCDFTSKFRRNLLNHKKLRHQRHRKCPICGELIIASRFQRHKSSLHKIKNYTCSWPDCGKAFADNSALKNHVRIHLNFKRFKCKWPDCGYASEQRFTVITHIRVCHFKLPRTKKKQMELNIVQDEQTQNPYDYLETCREDICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6W8</accession>
    <name>A0A922I6W8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Positive regulation of invadopodium disassembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NAV2_1</name>
        <name evidence="6" type="ORF">DERF_000213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nav/unc-53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057568">
        <property type="entry name" value="CortBP2_NAV1-like_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039041">
        <property type="entry name" value="Nav/unc-53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057126">
        <property type="entry name" value="NAV1-like_ubiquitin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784:SF28">
        <property type="entry name" value="PROTEIN SICKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12784">
        <property type="entry name" value="STEERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25408">
        <property type="entry name" value="AAA_lid_NAV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23092">
        <property type="entry name" value="Ubiquitin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="1365"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="529"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="680"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="816"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1022"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1079"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1176"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1218"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1667"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1112"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="981"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1027"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1081"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1176"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1227"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1682"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1694"/>
            <end position="1706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9526096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1763" mass="198785" checksum="3B94520BC3FA7E96" modified="2023-02-22" version="1">MSLYCTLPRRNRRSSTSIISSVNPTLLTTNIRDNANIMMNNDLLSSRGWICGGLVSSTTSFAKPQSFSTNTTNDTSSSSSMIPPRPYGNVGEQSCNGHSIETGSIMAPISPQSDYLNFYNTLNYKNQDSLCSNQTSLPTSTSFNGHLSSWTSFNDHYYSSRVENHNFHPIAITPPTETSDTVTFTESVTSTFDEYSSNSGPSTKLYYACDSIQLPSQSSLNNNNKSSLTRPRTMPNFYGTIDEDGLDPDDDEDEDEEDLQSSNEDFITGASVDAYGCSVEDITEVDEDQDSEEDYFDELERQQRERVARMFDLSIPSNSKSHHNHNHHHHHHTGTNILSFNRYSSFRSRSRQSLRNLSMRLSKFYRPKILSSSSSSSFVDDEKFRNNNNRATTTTQTSTPLLNSRKNNYFCYRPTITNDYVEDQSSSLPTSAFNGKNNHDKNNKIKRRLQENFNHHNRLKTFWKDKIWREFLMLKSSWNSTTSSSPSSSTLPSMINSRVGVRRNSINDFNYRHQKCSTIIDNHKLANGMQQQTHTLSTPSTTSSSSSSSSSSSTTSSSFSSPLNRYFERYFSSSRFASMRERISMKKFRSINRSNISLQPNYNCSTMVIDGNNLYDYQNVHHSSSSSSLMKMMANGQRSNINDTFRLQPQQPEKSSMTAGIIKKRPLSMTYDLVRFTKPIETNDDDDDDDETMNSTQQQQNQHNDHNNENKQQQQQQQQQHRYLHGSQDKAHMVAAFEQSLSSMTTRLQQLSSTSELKDCELERLRKTIDVLKKQGGSLVGHAKSATIMNPLGINGNDGYNSMIQILSKYKEKNSHAVNGDGVDDVDNDDDDDDDDLSNDLMNDGDDLITVDKHDQQNNHAQSNQHHRHHHGHRSLKNAKNLLIRRHTFNNSLVNNIKATTNAYCSSFSTTLKTSSLQRNPKNLNHNLSTKSSLSISPSPIRINDTNHNLTNDTTVLATGHIIDGDKFQRYLSNESVNSISSCGAATDSSIANGKTKKKSKLKLTGSNTSWIRSSFSRAFKKKSSSKTRDSSQHGRDVASDVEMTSGTGQSEPEGDVHSVPSSPLMSIRSRAKSAGVNMYNDRNASRSTNHPQSLSESKAFESDTMAETSDLEEMKDLRKQLREKEMQLTDMRLESLTSAHQLENLKEIVNQMRAEMMNLKQDNDRLQRLVHHKSLASSQSSMTSAIGSHGSSTLPPSAITLGNSGLVAPMEDSNSFESVDMDMSPLHSSNTTNSNDESPKLVTLGSGSHTLATLTITTKTNWDQLDTLIKKCFKDHLIRVDSSLALGITVDSLACYRVGTEKILRNFYPFNHHHKPTVPELLPFGYLVNENHINLQFKTTIDSLAFDTLTPKSVLNEFISMLIENRRLIFSGPSGTGKTYLAHKLAEYMAIKQMDSSSVAIYSRAVPNIGGANCVPPSGAITTFNVDHKNAKELRAYLTNIAEQCQLEVALTPLPTVIILDNLHHSIDSLEDIFNDLDKISIAKSPYIIGTINQSVHHHQTMPMFQRHNFHWIMLSVNSEAVRGYLNRFLRRKLLETESRLALSQQKIQPEVVQIIEWIPKVYSHLNKFLENYFGENISIGSRLFTSCPIDLNGSQAWFTDLWNYSILPFIIENLREHVRQNDGKLKGKIAIHSFIDPTDWIVTNYPWSSNSEWSDHLNRLRPEDVEDDKQQHHQLPPPSMNQKTLITNSRPSSSNNNYHTNDNNQCSSNGLVSEQFNKSSVKDIKDPFLQMLLKLKEASEYSSQDIGTNNQNLAEQTITRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I719</accession>
    <name>A0A922I719_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I719"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="451" mass="50487" checksum="3C868F66893A2353" modified="2023-02-22" version="1">MSNELKTIKISLSDRERNFCEDDQHRSETNLKDLILFTKENELDEQKPLDEEKFAKLSAINISCLELGGLTLSSSAIKLLGDCGAQKLQCLRIYDCLNVNDEAIKLFGQRFGKTIAHLEMLGNTGVTDVGLKALISSIGNLEVLHLDNAIGLLAEHRETITNMRHVWSRINGDELEKLSQFTAKYAQYLRHLDITFANTKEKTPEFIRLLENLTGLTKLSITCTANVAIEKELAQLLTKLSVNLTTVNICVWMGDGDVLIDAIGKLPKLVQLTLNGRSPMRHIDFRINKTLVPMANLKDLKNCRLILKNHSKTLLDKFATHLPKLETLELEGLDIDDQALSNLSGLDNLTFLDIVSPTITDTGMAALIPKLPNLTFLRINDFGTDKIWNKTLDSIIGEASRRQQVPIEIVFTESCKLDLESRRNSLPKNLTVSKRNSTHLLSFPGSTPRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I745</accession>
    <name>A0A922I745_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GPN2</name>
        <name evidence="10" type="ORF">DERF_006215</name>
        <name evidence="9" type="ORF">HUG17_3005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimers with GPN1 or GPN3. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I745"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7638972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9522650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="319" mass="37452" checksum="559DF9003AADD0E7" modified="2023-02-22" version="1">MTENESLFGQLIIGPAGSGKTTYCHVISQHLLNHLNREVIIVNLDPDNETFPYQCHLNIHEMIRMTEVMQNENLGPNGSFLYCMDFLYKNIDWLYQRINEEFSKCKQRIQSTMINNSEKIDSQRRRRQRRPYILFDCPGQIELYTNYPVFKNLIHHLLDTNLDPEQSEKRREKFPLNMRLVAINVVDSHYANDPSKFITVVLNCLISMLHIETPFINVLSKIDLIERYGETDFRLDFYCELTDLNRLVERISDDQRLVRYKKLTEAIASIIENYAIVSFVPLNINDMETISKVITLVDRANGFYMADLSSNQDGFNYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I864</accession>
    <name>A0A922I864_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I864"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="126" mass="15073" checksum="01DAA953D77F7982" modified="2023-02-22" version="1">MQIFSAIDNRLQMTNENLLKFFVEGKRRKIANEIMFLFPHLFNSTENYKQWEYMGCEIVKDQLLTLEFLTPNNYKNIDIFRAQPFIIFKEEDSNICKYEYGGPKYMIFNLAKDCVKELNIAPHQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I899</accession>
    <name>A0A922I899_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA repair and recombination protein RAD54-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein okra</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RAD54L_1</name>
        <name evidence="19" type="ORF">DERF_006110</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Involved in mitotic DNA repair and meiotic recombination. Functions in the recombinational DNA repair pathway. Essential for interhomolog gene conversion (GC), but may have a less important role in intersister GC than spn-A/Rad51. In the presence of DNA, spn-A/Rad51 enhances the ATPase activity of okr/Rad54.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts (via N-terminus) with spn-A/Rad51.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I899"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="176"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="527"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9522546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="770" mass="88261" checksum="1CCF5FE0DF7A2FE3" modified="2023-02-22" version="1">MLRSKVPSIVAKRKLLGQTDNDENQSFIKCVGSNDDDDVRHNPKRSCNTGRTALISIRNSFTFRPNLKLVDDIIRERQSHDDHIREILNRPFRIPLKNYTGSYRSLGIKLSGPRRPLFDPGAPNALILYEPPPINAQEKLTKKDYQVHVVVDPVLCNVLRPHQREGVKFMWDCVTGVRINDQFGCIMADEMGLGKTLQCITLCWTLLRQGPEARATIDKAVIVAPSSLVKNWYNEINKWLGCRINALAIDGGSKEEIDRKLGSFIQTIGRRCCQPILIISYETFRLHTDILHSGDIGLVICDEGHRLKNQENQTYIALNQIRAKRRVLLSGTPIQNDLLEYFSLVQFVCPGLLGTSAEFRRHYENPILKGRDADATENDRLRGQERLNELIRLVNKIMIRRTSNILSKYLPVKIEQIVCCQLTELQRQIYKEFLNSKELAKVIRDDVKHSTGSRGGGGNASLVAITFLKKLCNSPQLAYDMIMENKEKKRDGKNAADLDFLLKHFPNDFNSLRGRQIEPTLSGKLKILDTLLAYIRHETNDKVVLVSNYTQTLDLFEKLCRARNYRYVRLDGTMSIKKRGKIVETFNDPNSMDFIFMLSSKAGGCGLNLIGANRLVMYDPDWNPANDGQAMARVWRDGQLKQCYIYRLLSTGTIEEKIFQRQTHKRALSTCVIDNAEEEEVERHFSLSELKELFRLELNTKSDTHDKLNCKMCKIIGQQPPADANCTDDLTVWYHCPDKRNLVDQILKRVWDQGITYCMHQKSHIQKDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I976</accession>
    <name>A0A922I976_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vesicle-fusing ATPase</fullName>
            <ecNumber evidence="3">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">VPS4</name>
        <name evidence="17" type="ORF">DERF_001295</name>
        <name evidence="16" type="ORF">HUG17_4499</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I976"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MIT" evidence="15">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="141"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7641455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9527269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="419" mass="47341" checksum="238FD08D4C73EA94" modified="2023-02-22" version="1">MTTLQKAIDLVTQATEEDKAKNYEEALRLYKHACEYFMHAIKYEAQTDKAKDSIRQKVFQYIEHNPTNGTKTKDDSDEDDDKEEDKEKKKLMAQLEGAMVIEKPNIRWDDVAGLKMAKEALKEAVILPIRFPNLFTGKRKPWKGILLFGPPGTGKSYLAKAVATEASNSTFISVSSSNLVSKWLGESEKLVKNLFELARENKPSIIFIDEIDSLCSSRSDNESESARRIKTEFLIQMQGVGKDMENILVLGATNIPWVLDSAIRRRFEKRIYIPLPDEEARYVMLKMNIGDTPNSLSEQDLRALADRTERFSGADISVLVRDALMQPVRKVQSATHFKRCRGPNPRNPNEIVNDLLTPCLPEESGAIKMSWTDVASDKLLEPLVSMSDMLKSLANAKPTVNEADLDKLQDFMQDFGQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9X6</accession>
    <name>A0A922I9X6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9X6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010463">
        <property type="entry name" value="DUF1057"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47533:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47533">
        <property type="entry name" value="PROTEIN CBG21859"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06342">
        <property type="entry name" value="DUF1057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="322" mass="37697" checksum="CFD28DEA056023EC" modified="2023-02-22" version="1">MIVKSNPDSIIGFESSYQQKQRQPQLELEHNEPQHQQQQQQYPYPVKYVTINTCSSLYRQWSKTKKSLYKRAIDGLDLLVEYADTIDQCHTDDDDDVNMITILALHGAPGSHEDFEPFIQYFGSKKIRFIAPNYPDQCTKVFRHSAEEKFEYIKDFLRAINVNSSIYPTVRLLCDQTDVQIKAVAFFNPVGHRRIQAMRPAWFTEGSVKIYQNKFGRTVYQIFGKGFIKATGTVTVRPDSMNNVMLSAQTMRYSNYKQLEKYLRKLKENQIPTLWVCGDNDRLVEKEIFYEMIEIMDGNDEYNWQKYDCNGKMLTQCKSIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA07</accession>
    <name>A0A922IA07_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tmed6p</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Transmembrane emp24 domain-containing protein 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TMED6</name>
        <name evidence="13" type="ORF">DERF_006268</name>
        <name evidence="12" type="ORF">HUG17_2977</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA07"/>
    <dbReference type="OrthoDB" id="10037706at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276966" evidence="10">
        <location>
            <begin position="33"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7638944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9522704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="243" mass="27973" checksum="DE11D01DD58318DF" modified="2023-02-22" version="1">MLPNHYLIIKLFHHIVAILIFQIILHSSSIEAENHNFELNAENLGTAFEFKIHIDAGKEDCFYQYIEQGSSLYIAFQVMRGGDSMAGFYVNGPKGETIMPYQWKQHAEIDDSTVPQSGYYSLCIDNKPSSFQSKLVSLYLASLKRDEWEKYIQELSEVDVTSNNATALLRNVQWNINEMMKHLEHSKQQHSYDGYLAESNNRYVQNWSILQCAVIIACSIVQVIFVRKLFESNNEFGKGKVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA31</accession>
    <name>A0A922IA31_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA31"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7551" checksum="AFC93F751186C5E5" modified="2023-02-22" version="1">MNGVFPTTTTTTTTGSSMKKKSENLKSVLSSLFHKTADCRHSRHHYQHSRGCCEKKKQKSKIVNTPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAF1</accession>
    <name>A0A922IAF1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RFX7</name>
        <name evidence="4" type="ORF">DERF_000554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000422">
        <property type="entry name" value="DNA-binding protein RFX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF21">
        <property type="entry name" value="RFX-TYPE WINGED-HELIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18326">
        <property type="entry name" value="RFX5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="365"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="874"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1335"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="878"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1031"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1154"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1168"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9526470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1668" mass="183707" checksum="89E367ED1E314269" modified="2023-02-22" version="1">MTTLVFDSTTTTTSTSTAYSSSSASSSSTSFSSDNDRNNNNNNDGNDNNVLLMKPLIKQQTLSSSSSTITTTKTTTTTTTTTVVPMLSLTSSSSSSSSISMQQQPHPLQTSSLQTTATTLSSQHHLHLLVASSQQQQQHQRQNYVHLPTTHNLLRIKLDQYKTQQQQRQQQHQQNLSMSSTIHVVGGHHQNLTITPTTSPSSSSSSSSSITNSIKLNVVKEEEDDEDVEEKMLKDNNNRKDGGQSNSRISNGQMKSTTSSLSSLSSGGANFINNNIKEYISETSKNKIADIIADIRKFNDIEKLYLYLQLPDGGNHHDHHPNGIDNVVGVVVGNDGTISSSNNGKKKTMNNSPFGKKADSEVIQTYAWIQSHLEEDISVSIPKHEVYEEYRSYCEANHFEKLCVADFGKAMKHIFPQVKPRRLGQRGNSKYCYSGLRKKIILTAPELPALETSDDNINIGDSYESSIIGNSVRKNNVMVNDIVWNIIHEWVEKTFNRKFKTSIDFARYLIETQNIKSDLDKMLSISNNNVNGNCFSTPQPPPPPALNLMAEQNTKIDLVSETTTTTTTANKSITNGKKISLNPIGSKLKSIMNDNNKKKYSSTEKGATTTTTLSTPQQQQIIDNSSIDNTTMMNCSKISTINTAITTSATNATTTTANNNDATLIQSLINRNSLTTLQQPPKTTATVVTNHIPEMVPVCNAKTVKILLGPNPQHHQQQQQQQLPTSTTLQTIPSQTCFMIDPQQNHHQQPQQLTLNTTNGVESFKYKPIQPKPVNFDSMSRFRPMTSVGNVPTTIAFIHNDQLINTNNGKPTAATLVFNCNSAINVSGNVNGNIVKSEDDNNLASNTKSTDKNHKRQIDNVEKEITFPLASKKRHVETTTTTTTTSTTNSDNMEPKRSSIITATDICDLKVNELETEALNEYLNNISSDSVIDNNIPLQQQQQQSNHQNIKNVNRENIVHIRRLLENHLAKVVPGNQQTASNYYNNNNNNNNQTLQNKNMLQNLLMSNKDSDHMSKHQSSSSSSNPVIYNQQQQQQQQQQQQQLSSPNSSRNAFIFQPISPRNTPTIPENSTLEMNMYSNGNNITSMSSATSQYKQHIQQTAGNATSISAGPSQPSSEANSPFVSPRNTPVSLPRSRNNSGQSAYSAYGAASQRQTPASLQNFDSGVSSISSSPFISPQSTPIPTTSLQRINQNQSNNLRNVSSQAVRVRHSSGPGGPISNRTTQLASLMNYNRSNSLSPMIISDNFFGQQSTMNNFNNLPSFNLSSQTSSKLLSGDDQIQSSPSSFVDNQKFSSVVTQTDPTFLINNQQQQQQQQQTKDHHSLSSDLFINSSFHHHQHQQQQSSTNQSTRQRHFSNPYGGVSTFSCSTTMNKNNNNDDDDDFSFNNSSLSSMSTTTTTNDFLSKSLFNRSQSVPLHPNMFEVANNFDSIVTDSGGDVDECLKSQSTTNEFINITNNNIQLLQHQHHPSSVSNNVLMAERTIANNNHISKSYPATPICTDMNFKFSDDNQLTTNYNLVQINDDDLLQSTLDDLLSNNDQDVIQSGQDLIVSSVQPGVVGGSLPSNGNRIDCSSPSSSSMMNKESNELIINNNDNNGDCGNNGNVTGVFNDDLLIDDTEQFQTLDAFHDCDNDFTNIDLVDHQNIVVSAAASVAATDASAYGGDNDFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAV8</accession>
    <name>A0A922IAV8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Preli domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PRELID1</name>
        <name evidence="3" type="ORF">DERF_006079</name>
        <name evidence="2" type="ORF">HUG17_3080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAV8"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7639047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9522513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="225" mass="26224" checksum="BF31EC4E508288A1" modified="2023-02-22" version="1">MTYFHHMQTFNYGWEQVAIAFWNRYPNPYSKHVLTEDVIHRRVIRDGRLFTKRLLMKTNSAPKWTERFLPAKHVFIIEESIIDSKTKTLTTYTRNIGLQHLLTLEEKVVYKTDHEHQQQTICERQAWINSAFYGLSSAIQRLGLERYKQNIKKAYKGFNLTLESIFDSAVRNRPISDCNSNSQLSIPTINPIFKERLRQSATKASEFAKSNIPTVIAATDSGDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAX9</accession>
    <name>A0A922IAX9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">sulfiredoxin</fullName>
            <ecNumber evidence="2">1.8.98.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SRXN1</name>
        <name evidence="11" type="ORF">DERF_000153</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17545"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="Rhea" id="RHEA-COMP:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
            <dbReference type="ChEBI" id="CHEBI:61974"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.8.98.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfiredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.2" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAX9"/>
    <dbReference type="OrthoDB" id="10023328at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032542">
        <property type="term" value="F:sulfiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16395">
        <property type="entry name" value="Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1530.10:FF:000001">
        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016692">
        <property type="entry name" value="Sulfiredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348:SF2">
        <property type="entry name" value="SULFIREDOXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="10">
        <location>
            <begin position="63"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9526034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="158" mass="18265" checksum="CF788DCB60DB6277" modified="2023-02-22" version="1">MKLQNCSYIITKIIREKSYLLVDEFYIKNHLFITSRYRLIKRTMSSSNSENRSIHSAQINEIHDVPMSVIHRPIPPVLDENKVQSLMQTFKDNPEQIPPIDVLWIKGRNGGDHYFSFGGCHRFDAAKRLGLQTIRSKLVKSTADDLRIYMGSSTPDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBD8</accession>
    <name>A0A922IBD8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GOLGA7</name>
        <name evidence="8" type="ORF">DERF_001004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBD8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002178">
        <property type="term" value="C:palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="7">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9526950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="151" mass="17655" checksum="906539A7B33389CD" modified="2023-02-22" version="1">MDHQAKPSSTTNTVKKIFIQRDYSQGTNIRFDTTFPKEFRDDKDNKDKDFKNKIDIKTYTDFIITLNTMYGEAEQMNAKVCMESCFACLTAYLTYLCFDTYFDKCLKKISAYIDEQNDIVFHPRGLHVTDPIERGLRVIEISTTISNNNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICT2</accession>
    <name>A0A922ICT2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICT2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="51" mass="5875" checksum="AE6E84A8C7412B21" modified="2023-02-22" version="1">MAPKRHHHKLQMVALESTGFHCKWFSVILLLAGLLSESIGPNNRTKLLYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICV6</accession>
    <name>A0A922ICV6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICV6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="127" mass="13374" checksum="72C763CECAB2C9BC" modified="2023-02-22" version="1">MLTRNMAITPLRCFMSPGLLLLTLIVLESFLLLSFQVNEAQAFKKLKAKKILKKISPILTLLTYLKTKKKIIPLPVPLPVPLPIVKKEPTYPCPEYGGGYSGGYGGGGFGGGGYGGGFGGGGGGNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICX8</accession>
    <name>A0A922ICX8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M-phase phosphoprotein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MPHOSPH6</name>
        <name evidence="3" type="ORF">DERF_001073</name>
        <name evidence="2" type="ORF">HUG17_4319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICX8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019324">
        <property type="entry name" value="MPP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582:SF0">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="138" mass="16281" checksum="0878620C7B10D176" modified="2023-02-22" version="1">MKRNSSGLSKNLLQMKFMQRSKENYENAEKAEQQRRHEQQQSSSRQQELLELCQKEGDKFLATNSFIFCENLEYGRMSFKGMNPEIEQLMRIKHSQHENDDGNESTMETKKTAKDEADVSDDEMTNVLTRRKKKRHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE21</accession>
    <name>A0A922IE21_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE21"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037318332" evidence="1">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="147" mass="17342" checksum="E348EEC45699E960" modified="2023-02-22" version="1">MNVHCVLCVMLKSIFTAFFEIMRSINNVAMIIPELNLIKSLRKVIISQKKFLFLAPLHVHMCLRDDNVQQACKILDNEKNVGFTSPLFIQLYMNIERINGGVNCYVRQVEKVALDPKYYCIVMYNNLNHCLWTKYHWELVVTKNKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE97</accession>
    <name>A0A922IE97_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_003762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE97"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036757923" evidence="2">
        <location>
            <begin position="18"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9529906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="181" mass="19298" checksum="E6A0992F9CB70697" modified="2023-02-22" version="1">MFSISFFAFSIIGLVSASYGGGGGGGGGGGHYDHSVDAAVKSKHSVSLYPVHSSHDPGKTPVVDINSGPLPLTLRFNSHSSNINAIQKHFSHPGQVQKQNAIDEPDLLIQNIKKPVIQEVREVIAPYRHRTQEVRPVRERIETLIAKGQDGMIGGGGGGGGSHGYEQAKQVSYPQEGYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEF2</accession>
    <name>A0A922IEF2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEF2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913">
        <property type="entry name" value="EPM2A-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45913:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR II-I REPEAT DOMAIN-CONTAINING PROTEIN 2A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="86" mass="10134" checksum="015A0ABCCF4A4C28" modified="2023-02-22" version="1">MTQQESGELELIEMQEDQALQLKYKSTSITEFWKFVPESKYPELKKAACRIISIFGTTYTCESFYSTLKFVKSKHRSMLTNQHLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEH4</accession>
    <name>A0A922IEH4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_003308</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEH4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="7"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="48"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9529423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="115" mass="12798" checksum="78E0FE6202A700B6" modified="2023-02-22" version="1">MMMITKEEILNLIQIARNSLVYSYCPYSHFPVACALLCHDDTIYTGCNVENAAYFGSICAERTAIVKAVSSGHRKFRAIAITSNLMNDICAPCGNCRQFMVEFGKDLIVILANHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF29</accession>
    <name>A0A922IF29_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HIG1 domain member 2A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Hig1 domain family member 2a-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HIGD2A</name>
        <name evidence="8" type="ORF">DERF_003635</name>
        <name evidence="7" type="ORF">HUG17_5535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF29"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF18">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7642490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9529768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="105" mass="11828" checksum="AEA276FDEE943528" modified="2023-02-22" version="1">MEQKKSTATDDEMSALEWIELQKTIDDYSKTETFFQKAKRRTLENPIAPLGFLGACGFLTYGLRALNRGDSRQQQLMMRGRVIAQAIGIGSIMIGLWLAARNESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF34</accession>
    <name>A0A922IF34_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Suppressor of fused homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_003912</name>
        <name evidence="5" type="ORF">HUG17_5768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUFU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF34"/>
    <dbReference type="OrthoDB" id="10038834at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.230">
        <property type="entry name" value="Sufu, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020941">
        <property type="entry name" value="SUFU-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024314">
        <property type="entry name" value="SUFU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038489">
        <property type="entry name" value="SUFU_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037181">
        <property type="entry name" value="SUFU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007768">
        <property type="entry name" value="Suppressor_of_fused"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016591">
        <property type="entry name" value="Suppressor_of_fused_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10928">
        <property type="entry name" value="SUPPRESSOR OF FUSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10928:SF2">
        <property type="entry name" value="SUPPRESSOR OF FUSED HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05076">
        <property type="entry name" value="SUFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12470">
        <property type="entry name" value="SUFU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011844">
        <property type="entry name" value="Suppressor_of_fused_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103359">
        <property type="entry name" value="Suppressor of Fused, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Suppressor of fused-like" evidence="3">
        <location>
            <begin position="77"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Suppressor of fused C-terminal" evidence="4">
        <location>
            <begin position="267"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR011844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7642721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9530075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="489" mass="54481" checksum="9B6CE9D89B7156EE" modified="2023-02-22" version="1">MEIRNNIPFNYSPNEFITAANGQSPMSLMTRPPPPSTVMVPMIPPGLQALYNCCARIYPDQPNPLQVTAVIKFWLGGPDPLDYISLYFNKGDEENGIPPHWHYISFGLSDLHGDGRVHRVSDANTPSGFGFELTFRLKKEPDETSPPTWPAAVMQALAKYVFQTGNILCAGDHVSWHCSLDNSESRIQHMLMTEDSQLGTVSTVFGSVTFIQIVGVCLEELQAAQQWNGLGIIDLMKSVPSVGGTYLITDMRRGETIFEIDPELREAVDDGIATQGSNLSGVSARCSFVTAKGDIDDNSQNEDNGKEKAKEEDEEETKTTKEDNAIQDMADNINIVENNRATSRHSSMSVSHDRNSRMSYASETGNNEPFELTQTKHFDAIHLKFNYEAGVLLPLALRGRLKHGRHFTYKNIQGDLAITFVTTAVAGSFVNSEQPYALHGPWLQVLIPDDHIDIILSELENVEYLDKESLPITYEWEKINLSITLQPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KT04</accession>
    <name>A0A922KT04_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">EIF2AK1</name>
        <name evidence="15" type="ORF">DERF_014430</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KT04"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1032"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="225"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="339"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="652"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="976"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1069"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="983"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1072"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1084"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1167"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9493693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1193" mass="135187" checksum="606DF4526936E1E4" modified="2023-02-22" version="1">MDCKIHISDDFLVPITLDIYDSCQPFHLRFQMDLNNNNNHHLNQSPSQIQINNHELIQRLPQAQPILDFDDGTMETATEKVPSIDSLPIEWINQLENDDKIDQETTTAAAVTTVKDNNKVVRRNQNRAQNLLLLALIQNSIEKNNGKDLVNKLFDDLKKFTSQTFQWRKNRKLFDNLSKRIEHKIFEHLSFITTKTIRAIDSNQPRPLLFDSRNYYDEDRYAKEFQELERIGGGGNGKVNKVQHRVDKQQYAVKIIHLKQGQLDKLNREPIIYAQLSHLNVVEYKTSWIQNCSSTMVNVNDGHDHNDEPTTTSTGNNNLLGDDLIEIISSKSINDTKMKEKSKFFRSSNSSSSSSSSSSLSSSVKDNGTKMVKNVGKQTDENKRETFLFIQMELCGQNLRDYIENRNKSFKTIDNLNLSVELKWFAQILAGVRHIHDKQLIHRDLKPSNILFTLDGKLLKICDFGLSSWSLNAYYKPVQSSSSLSINNDHHLQTSLSFGMGTPSYAAPEQLKQSKYDHCVDIYSLGIILFELIYPYGSGMEKSLMLDKLKIQRILPSEFNENDLYKMFGKLILAMTERNPAKRIKTIGVIERKLSSIHFQLKRKPSNRKSQLTLQQTQKQEIIRLKREKKQDTERIAALEKEIQILKAEINNNNKNHNNNGDDLCEKSSSSSSSLTKNQHPPIVAVNSGISCSNSEANIDKITAAIGIVYDNIWQYTKNHMIIVYKAVKTSYDATNHRLYLHDGQMISLEKSYPSFFSKSDENLKQVWNEMSTDENGEYMRRFISLGLFADQQSQFALNFMISSDGKKFRNILFRGSLGTIKSEQRKYPQTSHQSIIIISSGKSDHFASLLITIGHNSESNTVQVNWDVEMNRPIGYLCFSLSQRNAFRLQEQQRHCNTTTFLLQAVHYGFIAENTVYLVGTKYEEQYVIYTDKMVLEKRNHESRFWIKKLQDFFHCQSPPSQFVKESDSIPKEPWPIVGAGQQPSTTIKPFQRGQKPTQPPTVLSGQGDQQQQHQLQELPELPELSKSDKFYRLLTLVIFTVKNILMLIILFVVFYIVKQRERKAGIVVDGRGGGGIGGSGGSRFSSSMSSSSNLSSTSSSSFSSRASSRGSSTAGSTLLSGMSSSSRMTSGVRSKFSPSKMGGGKRKKVSPFSKMGGKGKRKIGSSAVGSSFASSAASSAASKMMKKRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KUE5</accession>
    <name>A0A922KUE5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="15">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ATP8B2</name>
        <name evidence="19" type="ORF">DERF_013015</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">Derf</strain>
            <tissue evidence="19">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="15"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9496996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KUE5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140345">
        <property type="term" value="F:phosphatidylcholine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000025">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000188">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF190">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="923"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1011"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1036"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1079"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="859"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1174"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1174"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1184"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1208"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="669"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="807"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="813"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="833"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="836"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="837"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KAH9496996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1256" mass="143525" checksum="D06B61D195439801" modified="2023-02-22" version="1" fragment="single">NERIIRANDPVFNSKFHYAKNYIKTSKYTLLTFLPLNLFVQFQRLANFYFLCLLILQLIPFISSLTPITTAVPLIFVLLITAIKDAIDDIQKHRSDNQVNNRLSKVLRNGKLIDERWFKVQVGDIILIENDNFVAADLLLLSTSEPNGLCYVETAELDGETNLKCRQALPETAELSDNIDRLAEFCGEINCEAPNNNLTKFEGVLKWRDDKFSLDNDKMLLRGCRLRNTKWCFGVVIFAGRDTKLMQNSGKTIFKRTSLDRLLNLLILGIVLFLIIMCLFCTIACGVWETLTGQYFRIYLPWDHVVPPNPTSGATIISILVFFSYAIVLNTVVPISLYVSVEIIRFFHSLWINWDIKMYYEPMDTPAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCTIMGIHYGDIIDDRGEPIEITEHTPAVDFSANSLYEKKFKFYDSKLLNEVNEGNEDVHEFFRLLAVCHTVMCEEKDGNLEYQAQSPDEAALTSAARNFGFVFRSRTPTSITIIELGQIQTYELLDILDFNNVRKRMSVIVRQNGQIKLYCKGADSMIFERMDPSCEMIKETTMEHLNKFASEGLRTLCLASKIIDENFYQSWKYRLQEASCSLENREEKVDACYEEIEQNLILLGATAIEDKLQDGVPQTIANLALAGIKLWVLTGDKQETAINIGYSCQLLSDDMADVFVIEGWEFDQVKGELMACRDIMKMVAKQQQQKNSNMNCDVSVITFEDDTTNIHPSCNNINNNNNKMNALNSLATTYNVTRLNPNPDSMNDSTEFALHLERLFLEVASTCKAVICCRVTPLQKALVVDLVKRYKKAVTLAIGDGANDVSMIKTAHIGVGISGQEGMQAVLSSDFSIAQFRYLERLLLVHGRWSYLRMCKFLQYFFYKNFSFTLCNLWYAFFCGFSAQTLFDPVFISFYNVFYTSLPVLAMGIFDQDVDDIFSVHFPLLYTPGIIDLLFNKLIFLKSVAHGIITSFVLFFVSYGTFKNAVGPEGINLDGHQIFGTVVSTILVIVVTAQIALDTSYWTVFNHIVIWGSLAFYFSLTLLINSNFIGNQYLGCFRMTLSSGQFWFTMFIILIILLFPVIAVRFYNITVHPTLSDRCRIKQRYLRKKALVHSYDPYIRRKSSALRSRRSIRSGYAFAHQEGFGHLITSGKIMRGKTQSYNLNVPNNHRMTTTTTTTSTSNTMNSKANLTTSSNHHHRHNQQHHHHHRHDQQQQQPHQSTINQLNRAKVTPISYNKQPPDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVM6</accession>
    <name>A0A922KVM6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA-directed DNA polymerase from mobile element jockey</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_012970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9496949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVM6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09077">
        <property type="entry name" value="R1-I-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038124329" description="RNA-directed DNA polymerase from mobile element jockey" evidence="1">
        <location>
            <begin position="23"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="502"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="929"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9496949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1201" mass="137265" checksum="10A7C97CDDB23862" modified="2023-02-22" version="1">MIGSESGWWNFFFVLFYCNGQSQNVQHSRAGTQQILINADLYKSSILCIQEPYTYSDNVCGLTGYNVLSSANPKAVIATVLPNALLIQQFTTVNFACVLFNDQQPFLLISAYLSPNAPLEKDNTPSTTDVSLEEDLDHLSRIISHYSSIPIIVTGDFNGWHPAWGSVASNQRGEAIFNFISSNQLIIINDGITPTREVENSATFIDITFVNNKAIQLISNWRVLDETTHSDHNLISFQILNSKPSPESSLTRIFKTKNINWDSFNLLAYKEINPYYERSRCLRTAEEVNDFVDAMTNTVITICKRTLPPNKPGKRVIYWYNEELKLKHQQCKRLRRKWKRSNNQFLKEAYLNHYIACLKEYKNQLIMTKRNSIRQFFSVQDSSSVWKQVYKWCKTPKNLNQSLKTIKTDNGWTNTPIETASHLLNKFFPDDPPDNHDQFLISTSAQYPQSTSNDVPFTAEEVYDAILTENDNKSPGEDGISANIIKHLNNLFPTLFLNIYNACLKLGTFPDRWKVSTVKVIPKPGSNLQTAKAFRPISLLSVMGKILEKLLYKRLLFWTYQHPTGLSDHQYGFRPQRSTEDAINIIISHRKEILTNNKYGLFVSLDVAGAFDSAWWSLIILSLIDLNIPKNIINIFRSYFSNRKAKLTICGESAEKLLSRGCPQGAKCSPLLWNILYDNLLKLHLPTGCYLQAFADDAFLVVSHENLNICEDRTNKALEKIAKWGENNKIEFNPRKTQAMLITKKRKTREIDIQMKGTKIEIVKHMKYLGVIIENKNKWNQHLDLIANKSRRLYHQILRTTGKEWGLSSDVLRTIYISAIEPILTYSCSSWNSILDLKTKRAKLLSIQRSFAISIIKGYKSISAEAALVLANIEPIDLKIRYCSSRYLLKKGIPDNEHLSQITFQLRAPFSYRPHPALTTNFSVTNCRRPHQINIFTDGSKLEEQTGCAFVALRNDLVIHIDKKRLANECSVFQAELLAILSATEWCIDKNFDARIHCDSQAAIKAVCSRNTSDALALNIQKSIQTAGIHICIIWVKAHVGNAGNEMADQLAKEATKGESIYYHLDPISYGLRFLKLIMTKDWNIAWKTAIKGRTTAAFFPSIEDRRNCHFLPNYVQTQFLTGHGRFAAYLERRKIHLSDRCICGERQTAEHVLLHCPATFNSRALVEARIGSLKSLEMNKKNFQYLLEYMTDAYKILPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KW71</accession>
    <name>A0A922KW71_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Elongation factor-like GTPase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">EFTUD1_2</name>
        <name evidence="2" type="ORF">DERF_014059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KW71"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor EFG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="126" mass="14585" checksum="D3B070477477F947" modified="2023-02-22" version="1">MAGKMYAVIGRRNGRILHADVQEGSQIFTVNAVLPVIESFNFVNEIRKQTSGKAIPQLSFSHWEVIDLDPFWTPTTEEEYKLYGEKADTENRALRYVNAVRRRKGLHVEEKIVEHAEKQRTLTKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KXQ0</accession>
    <name>A0A922KXQ0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">dTCF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TCF7L2</name>
        <name evidence="15" type="ORF">DERF_012018</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Segment polarity protein. Functions together with arm to transduce the Wingless (Wg) signal in embryos and in developing adult tissues. Acts as a transcriptional activator, but in the absence of arm, it binds to gro and acts as a transcriptional repressor of wg-responsive genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Binds to the beta-catenin homolog arm or to gro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCF/LEF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KXQ0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990907">
        <property type="term" value="C:beta-catenin-TCF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007500">
        <property type="term" value="P:mesodermal cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072091">
        <property type="term" value="P:regulation of stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007435">
        <property type="term" value="P:salivary gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035277">
        <property type="term" value="P:spiracle morphogenesis, open tracheal system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21996">
        <property type="entry name" value="HMG-box_TCF7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000001">
        <property type="entry name" value="transcription factor 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024940">
        <property type="entry name" value="TCF/LEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373:SF38">
        <property type="entry name" value="PROTEIN PANGOLIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373">
        <property type="entry name" value="TRANSCRIPTION FACTOR 7 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="370"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="370"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="141"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="224"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="304"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="515"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="570"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="224"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="593"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9501152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="690" mass="74644" checksum="F42744EB5E6F69D5" modified="2023-02-22" version="1">MASMAAAASHHHTATGSPLSPFATMMPHSHHPQIDAASRHLPQPPPAHMGIPPVHIETKAVSISAWMDFDLSNIARNHSLYNLSGHGQYSHSVLSDLTQQLQWPNPAMYQLQSAAFRSPYPLSSVPSATFPGFAVRTPPIMPPHPASLSGHHHHHPHHPHHPTFPPHPSFLPTTSNNIQPNNVNTMTTTTTNNGSTNKSNRSSSSTLSLGKNNGFPFFHGINGSSSSSSSISPTLANNNNNNNTTTTTNRMSSSSLSSSTLTNENSSVNRSHNRHHINNNNNMDMDNGHNFNSKLLNTVSQQQCNVNGNGSKLVNNNNHKNSQTNNHSISSSSSSLNGGGGGQSSLQQQLQQQKQQQEQEEREREQKMHIKKPLNAFMIYMKEMRAKVIAESTLKESAAINQILGKRWHDLGRAEQEKYYDKARQERELHMELHPGWTAKDNYAINGKRKKKKRERNADGERGALKKCRARYGLDQQNHWCKPCRRKKKCIRYLEAARAVAAAAAAVAAAAINGNTSRSDTNESDNFGSISSVEAPTPESKTTNESDHLPSPLFYPSSAHTHHMYPNSVATVTSSSLPSPIGSRMSSLLTPNSPLTTASSFSSSSGIGSSLSSASSTTSTSSFSSLVTSSSSSSSTSSSGSSNVPPRNSPFSIEQLARPHCPQIAVITQLPTPPSSTDSTAGTPAMLWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYH2</accession>
    <name>A0A922KYH2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYH2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="223" mass="24323" checksum="44A762A7EF1BC8CD" modified="2023-02-22" version="1">MNSTSNNNNKCPTTMTIKLFRIQMMMTFLMMLMIMIIIHNNNNNFVNCQISTSSSKTTTTTTTSKTPIYNDYGGYKKNNAYGYGGSSAGGGGGGNGHYGGYYQGASQNGGGLGGLIDVDVHNLNNGGKHVGVHVPIFYTMDLDKDPYRKNLGLSILDGLIKVRVNDDPSYNKSPYSSSSSYGRPSSPYSSSYGRPSLEALLLSGKKKFKEIELYELLAQHLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L044</accession>
    <name>A0A922L044_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L044"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="70" mass="8416" checksum="2106E4B450642734" modified="2023-02-22" version="1">MNCFFICYFEQEDYSEHRIDELLANELKSMYGSKVTTVLIVLMRDGLVTRYFKKAWGLQRKSKRISRVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0D0</accession>
    <name>A0A922L0D0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0D0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8274" checksum="E53ABBE466064998" modified="2023-02-22" version="1">MYHFVLFGGNKQIQGPQIGCFLSGAFDAAAAALFDRPRLINFLIVRLVQWRCAWDTNNQTDEQKKIQISTYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0T0</accession>
    <name>A0A922L0T0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPL29</name>
        <name evidence="7" type="ORF">DERF_013666</name>
        <name evidence="6" type="ORF">HUG17_0984</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0T0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7645446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9497702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="8270" checksum="1AEE22C10E9B6E4C" modified="2023-02-22" version="1">MAKSKNHTNHNQNRKDHRNGIHRPKKMRKQSMKGVDQKLLRNMRFSRKHNKSREELLQLEAQLRQAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0Y3</accession>
    <name>A0A922L0Y3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leukocyte elastase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SERPINB1_3</name>
        <name evidence="7" type="ORF">DERF_009499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0Y3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00172">
        <property type="entry name" value="serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="6">
        <location>
            <begin position="12"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9511014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="373" mass="42007" checksum="4B1B88F7393FED1E" modified="2023-02-22" version="1">MANDNHNNQLVMKLTKNLHESGKNLVLSPFSLTTAIAMVLAGANTHTRTELVQFLFGTKVTNNEDSKLMLDNFTKDLQVFIQANQNVLNNANMLYSNKNLQMKDTYVDLLIKKFMAVAKQLDFHDTNAALAEINGAVKKATKDMIPTLLDQIDPETRAILINAIHFKGLWKYPFNKEATFDSDFRKSDGTVIKVKMMSQKKNFAYYQCEDTGLKALAIPYTAGSISMVILLPAEGKTIESVLETMQNDNNLSQILNKMDTLDVQLMMPKFRIESTHHLIPHLVRLDVKSIFTNEADLSSISSEKLFVSDVIQKAVIEVNEEGTEAAAATAIMMMRCCVMLDEIFFTVDRPFVYMLISDDRKHVLFTGVCENPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2A7</accession>
    <name>A0A922L2A7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_010179</name>
        <name evidence="2" type="ORF">HUG17_0188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2A7"/>
    <dbReference type="OrthoDB" id="6512971at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7644650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="141" mass="16417" checksum="584208C7652BB2FE" modified="2023-02-22" version="1">MSKLLQERLRFRLLRAVLFVSNVTSLIINVLILIFGLDFIKAFIRVPDATDPTVRTFAIIECCLCTIAIIGIIMRNFYTFTVYTVLLIVYLVCAAIFTRVPVGWFFLLGFILVSLAVLFDYLLWLNRKQLKQMKRENPYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2A8</accession>
    <name>A0A922L2A8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_010613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2A8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9505841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="499" mass="55865" checksum="584A37C64C89867D" modified="2023-02-22" version="1">MTGNKMGSREFVRIKSSSMLIQPTPSSSTTKQQQQQQQQQQSSNNNPKIRISSSSSSTTRKEKKSSNLSRSKMATNEIVNVGGGGGGSDIVVGCNADNGDGDVIDDNDDDDIDVGLPQFEMMKFKNKNPTSIDHYHHLKHSKQRTNQHSSDNNSHDDDVGDVISNKCDPFSLSSSTSPSRSSAHSYKSHPNAIILKQRHQKNQESSSIERRNENQKFPVICNNIHDDDNRRLSEQMPQLTTPLAQRKKSSSTMIVTTSPIKSPVPKSSLTNITTLSLQQHNSSNDHNNGNDMNKSSSLSTTKKLKNSSISPSPSPSSSSRRRSNVHDQSKQTKRNLQCEQTSPSSSTTINSKTNRQNNSDSCHGGCHCQQRQQQQQQECYDQKNNKINNKQSDSNYEQCTATKHSMKKKSKIKQITMIDDDYCGEMNPNLNQIKNSDCNNQQQQQQQQQPPLSQQQHEPLSQVLVTLKDQNKNLIKEVEDLRIKLEDAEGKKIENQSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2J4</accession>
    <name>A0A922L2J4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2J4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9512002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="8754" checksum="93CE1DF0E6E8E50A" modified="2023-02-22" version="1">MIQYTVYPLGPCGRLLGACKPLVDGLYLGPCGRLLGACKPLVEGLYLGPCGRLLGACKPLVEGLYLGACIFPTDIGDGLKGVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2R1</accession>
    <name>A0A922L2R1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Translocon-associated protein subunit beta</fullName>
            <shortName evidence="11">TRAP-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Signal sequence receptor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SSR2</name>
        <name evidence="14" type="ORF">DERF_011059</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TRAP-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2R1"/>
    <dbReference type="OrthoDB" id="5860827at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008856">
        <property type="entry name" value="TRAP_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861:SF3">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05753">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016400">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037816446" description="Translocon-associated protein subunit beta" evidence="13">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9506321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="197" mass="22438" checksum="69F800819CD9F9C9" modified="2023-02-22" version="1">MLTMTRNIPFILFVLISWTLMVSTDEQNSDRARLLAEKQVLNKYLVENKDILINYNIFNVGSSSAINVKLSDNTFSLAHFDIVGGSLKFTIPRIAPQSNTTHTVVVRPKEGIWGRFNFTAGELIYSSEGSNELQYGYTSEPGDGYIVSLKEFDKRFSPHYYDWAAFLIISMATVLLPYLLWNGSKNKYEKLSARKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2S0</accession>
    <name>A0A922L2S0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal RNA adenine dimethylase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RRNAD1</name>
        <name evidence="2" type="ORF">DERF_011089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2S0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF2">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 25B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="110"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="436" mass="50443" checksum="2D7D70F12CF81574" modified="2023-02-22" version="1">MDSYVLDFYLNNHWNKLPAKWSECLNKLNLFDIPWLLGISNNQSKCTIVLPLTLFCLRSLSTTIRMVRSKPFHEQLFLSSNLKQSQERHQFSENLSTDLDHIIARGIKAKKRHEIQQLCKLISTVMNKFGNNLDIIDFGSGKCHLSRILGLCYGFKVFCIEAKSENLNGAIKRENKVLRALKKYKRFDVVEEENMPIKANCFLTKENRIDELFGDKITRPHLLLGLHACGSLSNLILEEFATNPNSHCLVLACCCYMNSELFRFPMSQLLKENSQFTLSISAKELACHAIEKFLNDFSQKELDSLKVHGYRACLEVLLERYAPHMRYKSMKNVKITEQMSFKEYVTRATSGLDISIPESIFESNVDGKIIDNFINQTDQVILFYSLRLLLAPLIELYILMDYRHYLCEQNPVQNTYLIPLFSPSISPRNFILIAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3C2</accession>
    <name>A0A922L3C2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynactin subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DCTN2</name>
        <name evidence="6" type="ORF">DERF_011698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3C2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9506996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="361" mass="41748" checksum="1E3F555E51623BF7" modified="2023-02-22" version="1">MMNSTSKYANLPFIASGERDVYETDDLPESDRILQQQQQQQPDSSIEIIPSNSVDAFNKFAVADSIQKSSSLESKESNVSLVEKYKQIQLEIENLQHSIQSNEQSTADDSSFMPKDIENLFTQLANLHDVCFKKLDTSQLIKDVRREQQQPDDQPIVYELYRKPDKEDIVELARMNALEQRLKKIESTIGLNEIIKDSSSSHPLLNNYLKDQSIMDIVINLSNKIVQLDYQSLDRLDARLQLIVDRLQQINEKKSTLTELDKEDRLNELYNCYVKINENRPLLPNILERLQVLNDLQDQASRFANTMTAMETMQNEIKTSLDHNNQNIKNLTEMFGKLSTIQNVVDDFQNRLDKITTKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3K5</accession>
    <name>A0A922L3K5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear pore complex protein Nup88-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NUP88_1</name>
        <name evidence="9" type="ORF">DERF_012576</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3K5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="570"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9501753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="733" mass="84134" checksum="EB002698C0BED25B" modified="2023-02-22" version="1">MAQASSTENNQLEKLVESIKKQKFDRNIVANLSCYYHDRLIVWNEDDQCLYECSLDDRYNITDIQIVTLSSLPTFTVNWICSNPMENYMAIYGTGGCMIVELPKNWSLSRCRTVAPKTITSFSLAERMFLTNRNLKLQCLRWHPISKRHLIILTNDNRLRLFDVFNEFEPIKTVDLGNDYNSGVYSGALGENAVSFDFGPSLSQYHDYNNSLSMTMTELIDIYSIFVLKENGDVLLLYLNLKDLSTFHCQHPPLKMRPAAEDNYGSEACSILCLDCVPPIIIIGTCSGLLYHCLAIENDPVNPDNNDDDDDNCDNDSSYQISTSKSMIIIPETVLNVFETIELSFPLATYQTMDNGLDDAGVDSISTALNLIADPKDGQRYYCQHSYGVHCVMVPFFKQIVNPTINNEFYDDKAIVEYLICTRPTIDDRKSQQQSKDCPTFPLGIGLTIKYGFTSITVILNTGELINKRLSNIVLTDFDDDDQIEFGFQSNLNESSPTIEHQQQAKKPNFSEHIQRLLSKTTSLPLIKSSKTDSKVGMAELEMLLNSIDVLRIEYLDKYLVAAKAINKRKTVLNNEIEVQLNQLDRHSKEKDEMLKKYVELTEKYDKIQEMTNFLTERLENIITLVQKQRPEMSNAELKLSEQLTEELQHLNEYREQFELIRQKRRYQDMQIQKYSLQQSSVIYDDDNDDDDGPPESQLQSPIQIKNIKQMLAKQSKEISELIAIINTLKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3M5</accession>
    <name>A0A922L3M5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3M5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="81" mass="9555" checksum="006B829A2F3DD12E" modified="2023-02-22" version="1">MILGNKGDDSTEDIIQQRIPHQTRRHQQKTEDQYQQRRSRSHQKLPEVNRCSLFISNALESLQNLDKKTIQQNIIVSLPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3N9</accession>
    <name>A0A922L3N9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division cycle protein 27 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CDC27_3</name>
        <name evidence="10" type="ORF">DERF_009102</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000018">
        <property type="entry name" value="Cell division cycle protein 27 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="588"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="622"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="656"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="9">
        <location>
            <begin position="1206"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="864"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1044"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1139"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="865"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1044"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1075"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9510580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1311" mass="148995" checksum="8AE5FB3B7AD71670" modified="2023-02-22" version="1">MFIQEPIKATIFFALENYSYADAIFLSERLYAEVNTEENLFILATAYYRSGKYNIAHSILTHNKYNPHKSPKCHFLRAKCCFHLGKIEEAANILLEPINVGPLSDQIFPKEDLIRIYGENASFVAQLLGQLFNKLEDTKAAVHYYTLSLKLNPFLWYSTEKLLQIDSSKVDTDKLINLDDLDLKFSCGTNPLINLFNSSQIDMIPSSDHVSTRTSTNNDHNKTSNEDTSHYFVTPEIRKPSSNNSKNQIELSTPYAILKQSPLSNKVDVITPESDGQWKMMTCLAPTKNIARNGHKFNTQNPTNPSSQFLIETSNLGSNRNHNNQTESSGHSFGVLCLDQESVNLLNRNNNVITNTKVDSKHGCLGSKESNQQDAQLLIDNNEQSLVVNPVTANNSPSKLTRRSSRLINSDTLSIKENSTSAKKIVVDRRDTPVKRCHGTISFDKSQKIVRQNNNENDSTLQDISFDVTKTGINAERSSANGLLELIKKITIACKRLFEYRCSEAIECFKKLPLNHYNTGFVFSMIGRCHFEIGAHDDAINCFKTCRQIEPYRLQGLETYSTALWHLQKELELSCLSQELIQFDKFAPETWCVAGNCFSLQKDYEISIKFLKRAIQVDPNFSYAYTLLGHELISADELNNAMSCFVNATRIDPRHYNAWFGIGLIYYKQEKYDLAYQNYKRSLDISSNNPILVCHLALTLFHLKKSRDAIHLLNEASKVDTQNVIIKYNRALIRFHMEEYDQSLVELEELKTMVPKESCIFFLIGKIHKIRGETHLALLNFSWAVHIDPKGSAIQYKEFTEPDQTFSEEFIIHTEIDTSLEMSLTPTTTPFAERSIYITGTINFSNISSEQSIDMTEINKLFDDHEVDEEEDPERDEEEDPERDEEEDPERDEEEDPERDEEEDPERDDEEIDSEYPIIHIHFIVGDSTDKEFEDILNQLNALGNTIDQELSQKGTKTKKFSSNLIDDGHHHHIIMQQSSLIETTSSPYPSPKNHHHHHPYAIHSYHHHPVDDDDDDSTNHQILTIVVSIRTDSPNFDDDSTFSDSISLIPSKQSSTSFGGSKSSMINQRKTNPSGHSSQSVNSSSGSSSCCVEIHQTNNVIDHHHQQLMNHMVKSMNENPDKSPIHKQPQQQQQIFLDQNDKTNNGDDDSTVCDGGGGGRDDSSKTVNDTIVDNKHEQNDIHNDKMDFDEKMRKGMAKIHEANVRKLYLKVFVEGNSSKCLLADERMTVGRICQQMAQKNHISLGINYYGSMFIKKSQSSFAILKPSLRFFKLNVTFRVLVEASSSMGCEFIISSKSVSVKSSSCDSNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3U7</accession>
    <name>A0A922L3U7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TNK2</name>
        <name evidence="15" type="ORF">DERF_006733</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3U7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.680.10:FF:000001">
        <property type="entry name" value="activated CDC42 kinase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000080">
        <property type="entry name" value="Putative activated CDC42 kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.680.10">
        <property type="entry name" value="Cdc42-like binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055175">
        <property type="entry name" value="ACK/TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015116">
        <property type="entry name" value="Cdc42-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037085">
        <property type="entry name" value="Cdc42-bd-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09027">
        <property type="entry name" value="GTPase_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22931">
        <property type="entry name" value="SAM_TNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="138"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="408"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="643"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="842"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="886"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="893"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9515965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="930" mass="106110" checksum="65CD6113FE4DD160" modified="2023-02-22" version="1">MGEVDDFDPLYQLLKEVQLEHFYQAIKSIDVTKVEHFDNVVFDDLINVRVGMGAPAARRLLEAAKKRNNNNNKWKKNLFQIILPNAKLKDHLNHNNNIERLKTFNNVDSSVDDDDTKNFDQENRDNSGLTCLISSKDIKLLDKIGDGSFGVVMRAQWTRTTNQENHMNTMNKTTKYVAVKVLKQQEILSRALEDFTKEVNAMHQLKHENLIRLYGIVLSTPMMMVTELAEQGSLRTKLIRTQGKIPLSILVNYSIQIGKGMDYLETKRLIHRDLATRNIFITLNDIIKIGDFGLMRAVPFDEDYYTMSDNMKVPFPWCALESLKYRQFSHSSDTWMYGVTLWEIFSFGQEPWAGLNGSQIIRKLEQNERLPPPDSCSQRIYQVMMLCWNHEPKERPTFTAIVRFFKMEQPFKLKALQEFDGNSKSTFDSTKKTMLKLYRGDEIEIIEGNPENYWWKGQNQRTFEIGYFPRSAAKDMRSLKTNDISKPLKNSFIHTGHMDPTGKKSWGNPEFIEKMYLENPIEPQDLIGFESSPSDETIAAVILETRNGRKNLDKLIKEGKIEKISNLNDLDVSNNLNHNDDNHNEQKEGVLIDFENDVNHVLTSAATMMNIVNENNNNRPPTSINNELAEIKFNTQEILGLYNQKPPPPPLPLLKNQLDNNNRINLSSEDDSDLLTMSICEPLEQQKQEQQREESPMNGSILDLNNKNNLYSKYYMPPFDANNGQLSQQQQQQQPYSKTRYYSAVCTTTGICECNNSTIPNQNLTIDPPTTNKPSCQCCQFDLSCGPCLPISSQFTPSVSMNFITPQPNCMIATNDLQQRSTTNNISSSFYNSHTLACTDETTLAPLSPPPPPPPPLPSTNTTKSTFQTKICKDFIDELEANFSRTKVEHSDSTAAATSGSTIVYPTINPPPKSYKTRRPAPPPPVQKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4A5</accession>
    <name>A0A922L4A5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Paired domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_007240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4A5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000013">
        <property type="entry name" value="Paired box 8 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF43">
        <property type="entry name" value="PAIRED BOX POX-NEURO PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="9">
        <location>
            <begin position="5"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9516505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="430" mass="48181" checksum="F708CE9DB01D4E90" modified="2023-02-22" version="1">MPHTGQAGINQLGGVFVNGRPLPLHVRHRIIELALLGVRPCDISRQLLVSHGCVSKILTRFYETGSIKPGTNHLRGGKNNRSANNNGTSSNSNSTPNIVKRILRLRHENPALFAWEIRELLRKELNQTENNDNNNVDVTDASIIQSTTSSNRSSYLSSLPGTSSMHHHQQQPSSSSSIIRSNVQPVTNFGHQEIMGPSSSASTLSSTNVSLNVINSSTIVQSLYQSTSSHWNTIIAHYQQQQQQQQQQHQQYPEPIYKEQAIQQREQPNRSKRKFKTYLIDEILKNDDDNNTETGVVDDNDDDNNNNNNRIESCTIDPSIVTERNNSNMIKLSGNPSSSSSTSSTLARNIKTFESITIPAEHQQQGCSNKNIQSNSNVYYNYLYQTLICKQQQQQQCSSKRELSNEKSMNSQLELSNSSTSSKNELNDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4I9</accession>
    <name>A0A922L4I9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4I9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019174">
        <property type="entry name" value="NADH_DH_b-subcmplx_su6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21106">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21106:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09782">
        <property type="entry name" value="NDUF_B6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9518053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="24324" checksum="ADAB50F6FF77A2D8" modified="2023-02-22" version="1">MGGHDHGDAVKKTSISEEEIRKILIRAKVQVPSESPKFAHSLSSGVLHTSIKGAYNNERARLGPNFNETDRQWRVKYLQSQNLHPSEPFEVPELSKVHYNPIRRFYRWPLDQVEKLLCNYMEKHYAITARKLIGGTLIGYFTILTLWYQLNYNVPNWEYKKGFRIFYTREVVLPGDSRWPMPNPRTQSWQHYDLDFHQRKAFRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4L9</accession>
    <name>A0A922L4L9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">ACOT13</name>
        <name evidence="23" type="ORF">DERF_007568</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Derf</strain>
            <tissue evidence="23">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">Derf</strain>
            <tissue evidence="23">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20809">
        <property type="entry name" value="C1_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01243">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000751">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001209">
        <property type="entry name" value="Serine/threonine-protein kinase MRCK beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057529">
        <property type="entry name" value="MRCK/ROCK_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF66">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GENGHIS KHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25346">
        <property type="entry name" value="PH_MRCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="100"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="22">
        <location>
            <begin position="366"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="19">
        <location>
            <begin position="845"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="17">
        <location>
            <begin position="913"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="21">
        <location>
            <begin position="1087"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="20">
        <location>
            <begin position="1423"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="474"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH9516850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1475" mass="170034" checksum="61CA3B7C72FE01E4" modified="2023-02-22" version="1">MSDNNNDDNNNMNQSPLTLTDRFERLSKLFATTTSLTSTIIDNKSYNYEFLIDLLIAVYTDIQRNVKSTRDKNSSAQKFSNLVKPLVDYINQLQLSVNDFEQIKIIGKGAFGQVSLVKSKHNEKMYAMKVLNKVEMTKRAEKACYKEERDILVNSSNDWFTKLYYAFQDSENLYLIMDYYIGGDFLTLLMKYDDTLPEDMCRFYAAEIILGISTLHDLGYIHRDIKPPNILIDSHGHIRLGDFGSCVRASTVKSDSSAPVGTPDYVSPEILDVIEGKNRNDCPYSYETDWWSLGIVLFELFYGQTPFYAESLVETYFKIMNHKTHFIFPVNAEVTDEAKDLISNLVTDRYSRYKNIQNFKDHPWFTGIEWDEIRYQTPPYHPQFSGPDDTSNFDISDIKPLNSPTAAMKTNKDVYVELSFVGFTSTLPKIIKTESQSNHKIENEIAAIITNNDENLEKGDNDDRLEQLSLENRLKTIQQEYGEMSQLLAEVKKEKNALSNKLRIKEGELDEHIEKNSQLRQQLRNYEKMKRQNLEEISSLQAELETQKILRKQDQIILKNHEEKIESLENQLQRDSESTHSFTNEKQCYLKKITDLEQQILLLEEENVSMKDQNNDLKKSYKELCCDLLNLDNQNLLFEHELKELVESVTERQRCSDSLDKMIEMLDFNIRKYKFLQEKNNRIGDNNTQIVTGNKSIHNTNTSWQERRSARVDKQELLTLQLELKSEILEKQKIHSELIKLQQDFDNVNMQLIDSKNEILRLKKQAKSMNQYGENNRNHLGFKNNHLMMGNDNVEDVSSRSFLKDFVIDMKAISSPISSNVGRKQTSVMSPDSSNENYDYHNKFGHSFIIRTFITPIKCYVCTSLMIGLVRQGYVCEVCGYACHVDCVDSGSSCPFDETKQRPVGIDPQKGIGTAYEGFVKIPKPRGGVRKGWIRMFVVVCDFKLFLYDIINTSDSSNLSLAYANMSNDSNYNTLINTPSISASTIIDMRDEYFSVSDVNESDVIHASAKDVPCIFRITTSMIGDNRDGLQKFTQLMLVDKESEKNKWIEALTELHRIIRRNKISHRNMLRCYHLLNTLQINSLRHIHNIHCCTMLDETRLLIGCEDCLLCCDLDIHSYHRLNQSKKFSQISYVHSEQLIVTLSGKQKQIKLIPIRALDNDGIDWIKISETKNASAFTVAFDNSVAYVCVAVRKTLSIFEITHKKSRYIFHHEIQMPVNIQTLNTCKDNLVAIGTSSNFVVYHVNRSEQPLYLVNQDSPDLIYLIQNSIDPFLCQPIGENEWLLVFAHYGVYVDDHGKRTRCLELQYPSQPIAASILRSESKQTSYLLIFALTHIDVFDINEIRWVQTINIKATRPLQTFADNILFCKTNALDLPNLIQITMKDDNLIRVSGDNIKAFTLTNLNQKNIQSQSQDYKKNMKIKISAPTDFSHISHLGPGSGPFSANLIDLNDMKEKKFDHSSKDSLSKSHTSLQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4T8</accession>
    <name>A0A922L4T8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mRNA-decapping enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_008489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4T8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09804">
        <property type="entry name" value="Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031953">
        <property type="entry name" value="mRNA_decap_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16741">
        <property type="entry name" value="mRNA_decap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA-decapping enzyme C-terminal" evidence="7">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9517871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="502" mass="57104" checksum="70DA277148DF3DF7" modified="2023-02-22" version="1">MVDLNEDSINLRALKRIDDNIREIIICAGQVAVYYFDFNREDWERKNIEGTLFFVRRSIVPEYAFVVINRLNTINFLQKITKDLEINVQSPYLMYKNINKDIYCIWFYDANQCIVLNENIDQVRNLIKKTSDTPSKLMNGQSHTPKSRQQLASTGTTPNNNQQQASEIMKLFFNNNNNNNNTNTNDNQQSQQGSLGIFGDSALPPPDLMKQRWLQNQSTENHIDNVSSEQQQQQQKSDDDLVKPIAQRRSVNLKELFESQLVLQETSNTSMKENSQHIAADDNNSQSLIDKPQSSTPKTVKQTPNKNELLMSSSPSMNSATFMTDDLKKKSLTSLPTSNANPSSSNSMSDGIYTAKPQQLIGDDILQDEPQQIMHNVIPAIHPSLFPIPMNFEPGFQQALLPAFHAQPPPQPPLPQQVSNHHHLANCITNVFEIQQDHNPIIGHQQQQQQQPITQNTGRTSISKPDMYLTMEQLKKALIHCLTNDADFLHAIHTAYVENIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4X1</accession>
    <name>A0A922L4X1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kynurenine 3-monooxygenase</fullName>
            <ecNumber evidence="10">1.14.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Kynurenine 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_010338</name>
        <name evidence="14" type="ORF">HUG17_0306</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:20545"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the aromatic-ring hydroxylase family. KMO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.9" evidence="10"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4X1"/>
    <dbReference type="OrthoDB" id="10053569at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004502">
        <property type="term" value="F:kynurenine 3-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070189">
        <property type="term" value="P:kynurenine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000129">
        <property type="entry name" value="Kynurenine 3-monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01971">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027545">
        <property type="entry name" value="Kynurenine_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46028:SF2">
        <property type="entry name" value="KYNURENINE 3-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0274">FAD</keyword>
    <keyword evidence="2 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="13">
        <location>
            <begin position="58"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7644768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9511915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="536" mass="62474" checksum="0E9719D4D02B870A" modified="2023-02-22" version="1">MLPDNEYIVNNNNHHYESTTIINDKKITNGNGIIVADKNHQDHQHHHNYQNGQRKNHVRVAVVGGGLVGSMISCFLARRGYQVDLYEMRNDPRKSEHVVGKSINLALSERGRSALRSLGLEKEIMEKYSIKMYSRMIHDLNGQKRIIPYGTRPDQYILSVSRRFLNELLLSKAEKYENVHIHFEHKLLQANLKQGHLTFQAMIDNNNNNVDNDNAFNDKQGKQQQSPHQHSKQVESNSDIILGCDGAYSAVRRHMIKLLLLDYSQKYIEHGYLELCIPPTKSGDYAMEPNHLHIWPRGEFMMIALPNLDRSFTVTLFMQFKIFERLTDETKLLNFFEKYFSDSIPLLTKDGLIQTFFSTKPSPLISIKCKPYNYEDKVLLMGDAAHAMVPFYGQGMNCGFEDCIELDELIEQHGNDKLDSVLDIFTEKRVDNCHAIIDLAMYNYVEMRDLVNKRSFLIRKTFDNMMHRLFPKIWTPLYSMVTFSRTPYHRCIEDKRWQDAMIDRILKFFFIIFGLLMFLIAAKLFDSNPTLKTKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L584</accession>
    <name>A0A922L584_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L584"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="127" mass="14092" checksum="FB33C63982EB953D" modified="2023-02-22" version="1">MIDSYNRLMIFDPKPYFIRAKPSNCRYIFVALVMAYLRCDRKSIFLSIITPRTLASSLKTRSCPLMLMAGIGTGRIFLEIGTTVVFSDAKVNLFSLHQLVAIVNNCLMDIAKSSGFLLTTTAVISSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5P4</accession>
    <name>A0A922L5P4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5P4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9518050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="104" mass="12365" checksum="303B5FDF8E791E9D" modified="2023-02-22" version="1">MNQSRMIQSNHICEIGKQFSFTDTCVYSNNNNNYRLPPTELINACNPELYQHQQQQQQQQQQGMIFEQMIIMAALIFVHSNRIQSSEFDKFPIFQISLHFNIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L658</accession>
    <name>A0A922L658_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General transcription and DNA repair factor IIH helicase subunit XPD</fullName>
            <ecNumber evidence="20">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">CXPD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">DNA 5'-3' helicase XPD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">DNA excision repair protein ERCC-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">DNA repair protein complementing XP-D cells</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Xeroderma pigmentosum group D-complementing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">ERCC2</name>
        <name evidence="29" type="ORF">DERF_007601</name>
        <name evidence="28" type="ORF">HUG17_1965</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">Derf</strain>
            <tissue evidence="29">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">JKM2019</strain>
            <tissue evidence="28">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="29" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="29">Derf</strain>
            <tissue evidence="29">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="20"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L658"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035315">
        <property type="term" value="P:hair cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000001">
        <property type="entry name" value="DNA repair helicase (Rad3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.20:FF:000001">
        <property type="entry name" value="DNA repair helicase rad15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 29" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="27">
        <location>
            <begin position="7"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00078828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00081072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00081188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00082576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KAH7646427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="KAH9516884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="761" mass="87334" checksum="82D4295FCFC5199B" modified="2023-02-22" version="1">MRLKIDGLDVYFPYNYIYPEQYSYMCHLKKCLDAKGHGVLEMPSGTGKTTSLLSLIVAYLKQHPNSLKKLIYCSRTIPEIEKVVEELRKLHEYYIEVNNDDALVGLCLTSRKNLCIHPIASKEKEGKAVDGLCFSMTASHKRQRNRDDSSKLCSFFEKFENEGREFVFPNGIYNIDDLKDLGRKMGYCPYFLARGALSYANVIVYSYYYLLDPKIAKLVSKELTKSSVIVFDEAHNIDNVCIESMSVTINKKILQKCQSNITTLQEEIQKIKEVDENKLETEYNRLVEGLREAYIAQKTDTFLANPILPGDILNEALPGNIRKAENFIRFLKYLLEYMKLRLRIQHVVKESPAAFLKDIHNKMTIDRKPLRFCSERIQSLIRTLEVNNITDFTPLTLLCNFATLVSTYLRGFTIIIEPFEDRTPNVPNPILHFSCLDASLAIKPVFERFQSVIITSGTLSPIEMYPKMLDFNPIVAATFTMSLHRQCICPLIVTKGNDQVPMTSKFETRNDMSVIRNYGILLVEMSAIVPDGIVCFFTSYIYMEQIIASWYEQGIIDSIQKNKLLFIETQDASETSLALNNYVRACENGRGAVLLSVARGKISEGIDFDHHKGRCVIMFGIPFVYTQSRILKARLEYLCDNYQIKESDFLTFDAMRHAAQCVGRAVRGKTDYGIMCFADKRFAREDKLKKLPKWIQSNMSKGVLNLSIEESTQITRKFLKQMAQPFSKEDQLGVSLLTYEQIKDENNQKKILSRVEINVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L666</accession>
    <name>A0A922L666_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_004408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L666"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9520718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="21185" checksum="B5FCBEAF4346C69E" modified="2023-02-22" version="1">MIFSYIVCLSGITNHWKKMRVSVLEIWAQLENVTNLKVTSQYEYHMKFKCNNCGTETENFMTFSDDNKVPLMGGKSFVNLIFKCKTCSRPSNVSVIEGSIRPYLAEDSLNFKPFVEFDCRGCDPLLFEPIDHFQCTNMDNTTEFNEVDLSELNWADYDERSNESVGIYDFKYRFTTVKKSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6G2</accession>
    <name>A0A922L6G2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LRRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_010075</name>
        <name evidence="8" type="ORF">HUG17_0114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6G2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052286">
        <property type="entry name" value="Wnt_signaling_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24364">
        <property type="entry name" value="LP06937P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24364:SF18">
        <property type="entry name" value="LP06937P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038277016" description="LRRCT domain-containing protein" evidence="6">
        <location>
            <begin position="32"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="7">
        <location>
            <begin position="309"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7644576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9511628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="570" mass="67528" checksum="F4E3714D6A85F108" modified="2023-02-22" version="1">MARIIIIIKWWSYFSSLFLLLLFDNFYLCQTTTTTATTNSSSLCPEQFENKCYCGHLDYYHHNNHNTYPLSRYFGKNRNTFITNCTDTNFNDSIILSLVPYETEILIFNGNNFSKLTGQQYQMNMNMNNTKSSRYDKLLMVDLSRNGIKQIDRNAFNHLQTIETLILNDNPIDFNHNVDDDGKLIFNKLIKLEELHLRNVTIDHRSSSPLISAIFNKQLKQLKIINLESNQIVQIDNGDNDRLFCSTPQLRRILLRDNRLEKFHQNLSCLTELSSIDISNNQIKHVDNQTIESLLSSTSLLYHINISENPFHCDCQLRDFYRFIRQQSQQNIVDHDNHYHKPTFDWIEEYQCHNNNGSLMNKYLDDLNENDFICDNKSSSSSSKMMMMTMMENDNEISMINIIGTEPSMNEMEKKLAIERYRFYVTLSYLVLTFLLLLLTILIIVLIYTNRNYIQTICSFCLADCCNYNNKNDYTALDKNDQPQQQQQQQQQQRRRQSSSRIGEWWQRIQKRSSSRSTTKIFVNDRQHRNYCDDHHDDNFGKNNHRFFIRHNNSSHNHHDHPMDIAEEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6V9</accession>
    <name>A0A922L6V9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_006130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6V9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF23">
        <property type="entry name" value="BCDNA.GH07066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="208"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="709"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9522566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1012" mass="118223" checksum="9D48F5136C60F6FF" modified="2023-02-22" version="1">MFTMLVMISDWFLHYIQNFFKQNIANQSDSNVVDGNNGNLMSTNSSSQTSYENIISLTFYYAWHVITRKIDHNYPDVRKNVLKSESVTRAIEHVSCDQYMKIQTTKHPEQQQQIKQNIRHKDVKDHNDYKQCIRQNRRRAYELFEELSSCISSSLLRIAGWILYRLLSRMFNSVQFSKAQIEQIRQRQKIFNNHKKQQQQQQQTELPILYLPLHRSYLDCILITFILSMNGLSPPLIAISEHFSIPFFRNLIRGLGAFFIRKKSNKNNIKRSMKNNATIDHQHDDNDNDPIHEAILRSYIIENLRQGNSLEFFLEDSRTSTGKVLMPNLHLLSIVLDALAEGSVQQVCIVPVSISYEKSIEGANLVVREQMELQPQRSSNSSSSASSFITTMMKIWSILRSNYGTVRVDFGKPFILDEYINQCMAQQQIQRQLQIEQKMIMKTNDIADTNVVTNDSDNIESNFPIPQTIDYGVTMADCVACPPSSKHVLYDAYRDSSLMSTHLVSFLLLNKYRSKGTTIDQLSLDMDWLRQIICRDKQQNLSIAGDSHILIKQAIQLLRQEELIQTEKVQIIYLKPSNKLQPLLHLQHYSNYCSSLFIFESVLAISLHSFVQQTEISSLIYDPSTFVSNLSINKREFFQRCRTICSLLQNEFIFIKSCQSLDQMLAKTFIDSFCKRDIFILNPNKPTGLTLPMSDVANHLYPQHHHHQNQNVTNHSSSLSSTSSSFNRLNRWLSPTRRRQRRRNRLFKNLDVTLQNECILEVDEDRLIDADDEHDEIINVVDCIKDHQYHKHLSSSNDDDDDDNENHHHHHLPQEFYIRLTEKNCQLLSLYRSILEPYVQTYWFVADRIANHYQNSDSTESATKLMNDSKCINHQQQHSNVKNHNNKPIIMENDIINIDEKIFLKMLISSAKQMAHNGYIYYECASIQTLKNALKFFASFDKDVWMAADSNNNNNHHHHHNNDNVKQQQVQRKDHNQYSWQKYSMNINHGRIKTIAELLRIFIRNLVQPKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7X4</accession>
    <name>A0A922L7X4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7X4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7562" checksum="FD8A22D1160D024D" modified="2023-02-22" version="1">MFPIYDIQDLIPLIVLMIDDFDDDDDDDYDQKKTLNEFLERLHFYFKSKLILLTIVCRDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L849</accession>
    <name>A0A922L849_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_000281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the vasopressin/oxytocin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L849"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005185">
        <property type="term" value="F:neurohypophyseal hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.9.10">
        <property type="entry name" value="Neurohypophysial hormone domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000981">
        <property type="entry name" value="Neurhyp_horm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036387">
        <property type="entry name" value="Neurhyp_horm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11681:SF5">
        <property type="entry name" value="ISOTOCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11681">
        <property type="entry name" value="NEUROPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00184">
        <property type="entry name" value="Hormone_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00831">
        <property type="entry name" value="NEUROPHYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00003">
        <property type="entry name" value="NH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49606">
        <property type="entry name" value="Neurophysin II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037058394" evidence="3">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9526179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="145" mass="15564" checksum="FD14B61746189765" modified="2023-02-22" version="1">MFRRESFSMMKIILVLCLIWICLFNDVRGCFITNCPRAGKRSIMTESNLGSNHLARECTRCGPSLSGRCYGPNICCSPLTGCNVGGFTAARCSLEAYHPILCTNPGAVCGPNGKGVCALNATCCTNDGCFIDKSCTQLSNDSNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9P0</accession>
    <name>A0A922L9P0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9P0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="566" mass="63882" checksum="3F456310A5DF3C33" modified="2023-02-22" version="1">MARRKKFYGKTTIPNIKHVISSSSSSLPETSGQNIVKSSNEQHINLELFQLLYFYDNLVQLMLLNQKECEQIQKDNEWINQNMKIVFRKIVEKNDVQSKMNDFPNKFMTWKNLKKSITTTFNITNNAKHLNVDQQMALPAAMTKSKINVNRKLHKNIEKLSRLAKKKSCAFSMNKPRTLTIISDDDDESDSDISSTTSESSSSESLIIEKKDSTKNVEQLVINCDPFNCMPSTSNGNGHQIRKSISTINATDTSSPNVLAMRIAGNQYIRPIIPNIDQLMLVNNQYQQQTSTLINNKLPIFGQIMINDNRIPVSQSSISNEQVLPTLSTDIRPKQPFTGKVLLFNSRPILVQNGDQVQLPVISNNSQHAPLPILVENFPQPNNKNGSSSTDQSTWGSTKKSPPEIIKIEDSDDEDDNHNKVASKSKCIEKKSNESHEQQQQQCNHQSYAVQHQGKSSKQILHSSVNHPDGELINVSMQTLRKNITETETNLANKRHCNAAANDNNFFLQTTTKCLPTPGLVNQNDSKSIKISIHKQKSTKRSKNSKAALLLHRNSYKGNEMNENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAB7</accession>
    <name>A0A922LAB7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAB7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8220" checksum="A39DA234DF7A8041" modified="2023-02-22" version="1">MKPFLCYINQLVPLLLNIFMSTIFLTVITLKMGKKGIGSLTKNYDRSSSWTIKHRFLFGAFVFSKKRIDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB95</accession>
    <name>A0A922LB95_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB95"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="581" mass="67437" checksum="7DFA56011C03F584" modified="2023-02-22" version="1">MEDLFRMFRASKTHLQPSNKQQMINYKNDLNVDKSINRIGQSSITSIKIPIQSTTSSSSWMDSDRNGFNKWPFINSNQCTHVSFEKWEEIWRTNIKGRAPKLEGIVFVNPNFARLYFVPSIAFHCEFYEYNEYPEYNQQLLSHKGTDYHDKWMKTMIQPTSCFVSIHCCNVAEIIDRYCIRCPHLSRISFHYYHLDEEVFNFISQHLPRLVSINLENSIGLNGKFIAKLGTMSRLLHLNLSGCDINERTLHCILDNCTILESLNISNNCLITGHCLRHSTVKNLKRLNLQDCWRLTPERLIEMVQPCLPNLVEILCNSGINDQSLIAITSKCSNLNHLDISFEEFTYYDEAGLDCLSDAGFCSIARLIHLRILSLRHVGRISDNSLNEIICSCKGLMQIVLNLRHRHKLTDARALRNLGTCTDLFYFEAVHNHFIAKNSIEHLSSLISSLQVLILRGDEFIKDDEAASLLKKCRNLRFINLDGCIDIGETTLASCIVHARKLLRMENENENSIKIFQASLVMTSVERSMLNSFVNEFPMNIRIRACDYRRNKVHFNEFDGQEIVECQLKEKFFPFYWHDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBC6</accession>
    <name>A0A922LBC6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBC6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="7884" checksum="31FD94602AB3A7FC" modified="2023-02-22" version="1">MPYFLRGFAVDVVFDADVVAIVPAIIGTVDVDGPIATTCPINCTNRNLLDKTIATLEWSFTRMTAHMFFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LC80</accession>
    <name>A0A922LC80_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LC80"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9525910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="75" mass="9244" checksum="3FDA912CBA7D7379" modified="2023-02-22" version="1">MRSSTSYTMEQSSSSSSWPNEFFVFLKEGKIKELFFYYRLYSVRIRILFYLLLYSHCDAKCQMKLKFKREERKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCD2</accession>
    <name>A0A922LCD2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_000282</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCD2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="11">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9526180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="193" mass="23368" checksum="9DFAA446D941B4AB" modified="2023-02-22" version="1">MSTRIFNNNNNNNNDDDNDTIKNNNQCRICYSDQDEIDNKLISPCHCTGTIKYIHYVCLVNCIIANNRFVCDICQCQPNGIKVRFVQRSFWEFIRSNIDICNEFFIILIWFLLIQIFLFVNYKDFDGTNSINTQQMNQQQQQQHDNHNYESDIRYWHHLFIQFSFMILYTLYVCTIYQKWIKQNLRIQIVQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HG30</accession>
    <name>A0A922HG30_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_016025</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the repulsive guidance molecule (RGM) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HG30"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040287">
        <property type="entry name" value="RGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009496">
        <property type="entry name" value="RGM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010536">
        <property type="entry name" value="RGM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428:SF6">
        <property type="entry name" value="REPULSIVE GUIDANCE MOLECULE B HOMOLOG DRAG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31428">
        <property type="entry name" value="RGM DOMAIN FAMILY MEMBER DRAG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06534">
        <property type="entry name" value="RGM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06535">
        <property type="entry name" value="RGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037136622" evidence="10">
        <location>
            <begin position="25"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Repulsive guidance molecule N-terminal" evidence="12">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Repulsive guidance molecule C-terminal" evidence="11">
        <location>
            <begin position="291"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="478"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="496"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9491296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="746" mass="86101" checksum="22B492B036C955BD" modified="2023-02-22" version="1">MFSKLFKSFHYFILISMLCLCVNSQPLLSSSSSNEQSLISMTSDPCTEKIGHCSFSSLDRMSCPEIKELKQCLDNLKQICRGSIHYHSFSSLVDRKSTEHCRVKNNNHRNRHRQRNKLQHHQLSSSSTQRPPIRSMFPESSWHQQLSTSNEAMVKSGPVHHRKNPISLDSLVNIPSSPVIATQVKFNNNKSSKPEYFQYCLQAAYNYTIGMNILPNKKNLVEHRPFMRHQRYKRQNDRVTDIMYHHLQPQRERQQRPQMNDLNSRLNETTAQLASKLIFKPVHPMKPSLTCIIFGDPHLRTFDSQYQTCNCLGARSMLEHPLFDVQITNTRILDQFNSTGVTKVNVLVRRFNPCMISNELIYETDSLAQASPAGTFTDGSVYNFNNMVYINTSMKDMVVTIHLEHIGARVYISQFIHTKFLNVVIKFLTSKSNLVRQDLVLNAINPISLCKSGCHHRELINIENELKRANIGLESTAQQNSHYSQSMPNFVNNLDAQEDNDNNDYYDSSNDDFDDDDDYDHEEDISDDDYDYDGDTHRKRRRIQKRDANFHENNDGDSHAINNGQQRPLNKKPKRKKDGRKKNRITTTSTTESPKKKARKSQRNRLRSALEKYPIQNNDLFSISKLRLDDSGYMNVGVITSESTDENMVLQDCYEKNLIGYYRLACLYDTMIKGAASTLPFVFASSFDEPKFTTLNNHLAYTNHSSNMIHDQSGSSTIWSNHCSFLTIICLIIVSQYCSLFLFDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKG2</accession>
    <name>A0A922HKG2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_015037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKG2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9662" checksum="26438EF46573C340" modified="2023-02-22" version="1">MTKFPFANIYVCFVPFVFVVKIDLRQVHGTKQTLTITQESRESTEFYHSKLSSPKIVTNHQAHHLRNVSFHLEIIEFNQIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLJ7</accession>
    <name>A0A922HLJ7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Replication factor C subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RFC4</name>
        <name evidence="7" type="ORF">DERF_013192</name>
        <name evidence="6" type="ORF">HUG17_6169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLJ7"/>
    <dbReference type="OrthoDB" id="10249205at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="52"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7643807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9497187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="345" mass="38868" checksum="41EE2A7080B754BF" modified="2023-02-22" version="1">MDNDSSKDSQSTPVNKFKTWVEKYRPSRLDDIVYQNEIVNSLKSIIASNACNLPNFLFYGPPGTGKTSTIIALSKQLFGVEHYKNRVLELNASDERGIQVIRDKVKSFAQRTISNNNQVAAIKIIVLDECDSMTKDAQSALRRIMEKYSATTRFCLICNYVSKIIDPIISRCTVYRFKPLKTDLVKATLLKVGHQEGFKVSDKTLDILIEISEGDLRKAITLIQTLSLINDGGDDDEISSDDICEIAGQVPIKRIEHFFNICRNSKSYSQLLTEIKQIIHAGYSATQFLCQLQEWLAMSDECLLNDGQKSRICWQIGIADKRLLDGCDEFLQLLQVGSCIMQTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMB9</accession>
    <name>A0A922HMB9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_013476</name>
        <name evidence="2" type="ORF">HUG17_1138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMB9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038276917" evidence="1">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7645600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="195" mass="21644" checksum="9325B9736389C4FD" modified="2023-02-22" version="1">MNKFISISFAFIVLFGIVSIQACVYDSDCGPSARCINSACQNVSDCITSVDCLKYGIYYECSSGRCIPSKHKICRSDADCKKNWIHKQCVNNNNIVNYSTMNKIISISFAFIVLFGIVSIQACVYDSDCGANARCINGVCQGVSDCITSVDCLKYGIYYECSAGRCIPSKHKICRSDADCKKNWVHKHCVNYRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMQ0</accession>
    <name>A0A922HMQ0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMQ0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7486" checksum="14D44615CF364D7B" modified="2023-02-22" version="1">MIENDDILNVSLANHDNNRFLSGINCGSGGGGSSSNSSSHHHHQLETLIFIFEEKKEEYSETNLESHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN35</accession>
    <name>A0A922HN35_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">COP9 signalosome complex subunit 7b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">COPS7B</name>
        <name evidence="10" type="ORF">DERF_013712</name>
        <name evidence="9" type="ORF">HUG17_0950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN35"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041481">
        <property type="entry name" value="CSN7_helixI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18392">
        <property type="entry name" value="CSN7a_helixI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7645412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9497752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="291" mass="33658" checksum="1DF2E6A96E1CADF4" modified="2023-02-22" version="1">MEAEYNISGNDKQNKSEAGSNVHLRKYVTLAEMATEPQNLIDIIRQALESPSIHVFGELLDVANIKALVGSEYEPYVNLLNIFAFGTYQDYRKQKNDNPNKLPDLSEQMIIKLRHLSIVSLARCRRHIPYQILMQELELDNIRQLEDMIIEVIYANVIKGTMDQRNNRLEIDQTIARDVREEDFQTITNVLNEWCRTCENILSNIEHQIQTANNFKEESIRSKQALETKIQSVRKNIKQSNNDTDDAMMTDVNTVYIQDVGGQKTKPCIQSCRSIKSSYKGSTNKSWRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN83</accession>
    <name>A0A922HN83_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_014841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN83"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11410">
        <property type="entry name" value="bHLH_O_HES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="65"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9494130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="337" mass="38515" checksum="96A8E790FEDFE6EB" modified="2023-02-22" version="1">MTKIAYIRATNRQQQQQSSLSMPIKSMNQSIILQPSIPSMMMNHQQHFNTNPNVLLGLDQQQQNGVRISKPLMEKRRRARINQCLSQLKTIVVDSAGQYTQNNKCKLEKADILELTVNYVKQLHQEHMEQKQQSTGKIDDDQYMAGYSECVRQMCEYLTKNQSKISYESVKEFLQQSLSITYQNHNHQRSQTTATTTTTTTTTFVTPPSPAPSSESLSSSSSSSNHGCSPPTSISSNSNSIIKSSSLTTTIITDNNYRKRKRFPESDTDAEITDDDSDGVIDDDDDDDDDDFGYGSDYHQQHENHPLNLKIMKHDDSQQPRRQQDCFDDDENVWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPB7</accession>
    <name>A0A922HPB7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPB7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="270" mass="31652" checksum="2625A455BE2D2EED" modified="2023-02-22" version="1">MAIFFCWKWLVKDECLHIAANDTGNSDLANLMYLVFGIKTFQKYKSTKNLPTDLKKSVDLLIEQYAMAKIVEKGSEYNKIISNAKHRINKRFDNWSRYQLKKSNFINSNGTFVPDNYEFPIFDDNVNAFLLNRNLIVTFKTLISMLQRSVLVGGTQSYKTLHKFIEIHSNYDEEDLHLETLSVSIQEHLTILINSFKDYCSDYFPDIPSNNIWIKGAFSVEIEKEEMLNLSEQEVDNLIEISCDTDLKKVFETAPLINFWLRCQKERYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPY7</accession>
    <name>A0A922HPY7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Fabp5p</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Fabp5p, variant 3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Group 13 mite allergen-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FABP5_6</name>
        <name evidence="5" type="ORF">DERF_013661</name>
        <name evidence="4" type="ORF">HUG17_0989</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPY7"/>
    <dbReference type="OrthoDB" id="412780at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14651">
        <property type="entry name" value="Lipocalin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7645451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9497695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9497696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9497697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="205" mass="22752" checksum="4AFB1E98247B9E1A" modified="2023-02-22" version="1">MASSKLKTFSFILYGVVTFLLLCAVLILIFKDDKSNCPKQKISSAEISNLLNDTLSTASSEPAVNNKNPEPIKEYNFVGEYELVSSDNFDEFLSELGIGYFTRLAATAASSRYFITKDGDSYTLKTVSTFGNSAITFKDGVPFDEDRLDGQTVKSTMQIKGNKWIQKQEGEGPDVHIIREFSPEQVKVTSIVNDVASVRIYKKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRP8</accession>
    <name>A0A922HRP8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">28S ribosomal protein S36, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_011166</name>
        <name evidence="5" type="ORF">HUG17_5938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRP8"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7643576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9506433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9233" checksum="1C24C0F5E34BD86E" modified="2023-02-22" version="1">MSTVAKAWKVIKPHVPLIHFKKGGHPTNQTHGSMAAVSATTTTTTTKTTTTTMSLMDDTQLPARFQRKPISELEMQLIETGGVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS43</accession>
    <name>A0A922HS43_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_012486</name>
        <name evidence="16" type="ORF">HUG17_8901</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS43"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="15">
        <location>
            <begin position="67"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7637797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9501653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="367" mass="43849" checksum="7479F57DC3CF7FB1" modified="2023-02-22" version="1">MTRILCHQQLIMMNNNKVIKTYSEESVKPYRWKWNWWFVISLTIGHIGALIGIYLAIMYAQIKTLVFYFILIQFGATGIICGAHRLWTHRAYRAHFLLRIFLMICQTLALQLSILQWCLFHRVHHKYSDTDADPHNAKRGFFYSHMGWIFTDRHPEYLEKSQKIDITDLENDAVVWFQHRFYVPLVLLITFMIPTFVPCFLWNESFINATCLNLFRIALSLHQTALVNSAAHIWGSKPYDERIKPTENRFTTYVTMGEAYHNYHHAFPWDYSASEFRWDVNYNPMTAFIDLCAWLNLAWDRKKVDRKMIEERLRKYGNQQLMNVFDRQPKNLLLDTLFGLLTLFWALWVLLALRFLIHSSFMIQIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSB1</accession>
    <name>A0A922HSB1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">3'-5' RNA helicase ythdc2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">YTHDC2</name>
        <name evidence="9" type="ORF">DERF_012509</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF213">
        <property type="entry name" value="3'-5' RNA HELICASE YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="5" id="KW-1053">Target membrane</keyword>
    <keyword evidence="4" id="KW-0800">Toxin</keyword>
    <feature type="domain" description="Cullin family profile" evidence="8">
        <location>
            <begin position="429"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1255"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9501681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1952" mass="229308" checksum="8574A6812B59F8F0" modified="2023-02-22" version="1">MIIGLKMSLYLVEKLRKHYDIVCRNDQECLQLRNQILELFRSSRKYRNDEFQSINILVNRILKRLSIAAVIAVWIISCQSVLKYWASCLPNYKDDNYVLDYLLQCWFRFQHSINSFYAMTISIQRFAYQLVKHQTINLLISMFVDNFLINHQEILFESIWQAIQNQKQNSNHQNDRVKQIFQLMIYIDGQSKNPIIYCRCFGFPYLKRLKTVYRNESKKLINENIKVDDRFDLIGYLRFVKSVINEELALARHYSFSIDLIRMEAKLLYSELIGQYQDVICDFDQFYEWIESKRWSDLQNLFNMIRFNENILQKLAKNFGEYVRLKSTTFIKLIDWKSNQYNWKSTFEFVHDCHELFRYCHEIVEKVFQNDSTIFRSLNTAYLFYLNSNNAFTCIISLLIHFVSIINLDDPNFPINVDRQTLIKSAFDLLMFIEDKSAIIHYNRRFLCQRILFGLSIDSVVQDINRIANLFDIIINPYSPSSCNVRILLKDYLRSHQSIADKMEVFLLNASLWHLDRFPSEQMFKIPIEFITIYETFKNQFQQNNSKKLLMLNPIYCSALVHYSNLENRQFHFIVTLKQLSILLVFNEFDICNYEQLEKTTELESDQLKTTLNVFIKYKLLLVANTNDQDESKDLSRQIFIFNDQFKGIEIMTSSITTKFSEQNTNFIDWIKLEQLSLGYDIQKIVAIYESVSNASNSTKQFDGGNRIMDKYLVIEAAIVRTLKWLVCVANLETLQQNIRQKLPYTPYEPIITDTDEFRNIINSLQQRGYLHCMEDGRIFDRLTDSEEFEIVIRVCDMDLVTLDKFVKNIDSFLSARLLNILAEKFSDDKIKAIQMPDCLSSNQLKCLCESLLGNSDNNQFSIMSDWFYPYAGNISFIRSTKKNGLNGGTYSNVYNSRRSIRLNFQSMQSIKDLLLKFSINKLKKQTSRSADQQQQQQQHQHHQQRFGNNNFNLFTYFDTKPIVPKFIHKQCNDGSSINIVNNEIENRWLTPPSSSSSSSSLPLWFGTSKIQILNGLSKNDCLDLLIQINNDCSQKQQPCRIVYLQSSTIMTFGWHWQSNKWLMINGIQLVTRLCWKASITSLNNSIIFFEIDTFIRALTRDLDMSLLTHLIIDVNDLTSLFFNLFLLYLKENMENLDHLNMIFLTQDSKRSQKMIDYFGPNVFYNNMADRNLTNYNMAKLQYFFLDDLQPMSITSTSSLENLNQIQQVTTTSIHENHSELIIFECWTENVEINKMIEFFQMFPWQINYQCKRIEGITPLITAIVRGNHTNVYQLLKMGANPCLASRNGLEPIQWAINFRQQQTFQLLFVHLYTMNVSFDLHIRRYLNFPHRPLSMTNPINNQSYHSKVNYNLILQLLYNMIKQLYHNHWTTMNQRSSIGSILIMLPSYNHVSTLRKLIISSMIEIQIEFTIFCLYPNVPNNELDAGIEISSSSSNHIRVILSTFNVDSILFKDVYFIINTGNRLMKMPNSFSDSTLFRMVPNPTENIETKFILANNQTFPVIIWNLYRRDEFFDYEIDSIENPISIHSNDSLYHCIFAAKFFKFKNIGCLMDIFDRMILPPNKEIIYRALNFMQNINVLDTNENMTTLGRMLIDISIEPHYAKMIIVSILLRCLDPILTIVCALSSPKSLYQQLQFLDENNQQQDEFHSIHPGTNNLQTRLSKNSDHLNLVYAFQKWQEICRLNAKSYCSMNQTFSKTAKIMNQNEFKESFATFEMIYSLRTKILGQLRAIGLVKGKGLMNIRYLNSNSENFSLILAAVTGGQLFDHFAQIIDSYSRQCHSSNPNEILYMEPNSILNLSSSNNIESMNDALILFDRKIQCGQISYIQNCTIINPLTFIIFVDDNSIDYNRDRNCIEFMNGQFEFHNDDDDDGSGNNLEKLFVIRQRWQQLIRKRLENMQQVFNEDDENFLENMINLITVADESYGFGPHPNIGRAPQVMSTYFCSTIRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSF8</accession>
    <name>A0A922HSF8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSF8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="6945" checksum="88BF4A6C33510302" modified="2023-02-22" version="1">MKIHEKTTPLLCGDYSHLFPPFHHPKHCPVICSTSTLDVEEVKGQMISLQHRGHHHHNGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTH4</accession>
    <name>A0A922HTH4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTH4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9505932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7742" checksum="C6FA88E42B36323F" modified="2023-02-22" version="1">MAQLQRKILVQITSSSSATIHSVIFQKHPPPTQNNQQRQQQLNPETKKENWKIGNSFFVVVVIVTGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU10</accession>
    <name>A0A922HU10_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="4 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">G6PD_2</name>
        <name evidence="15" type="ORF">DERF_012407</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15842"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="4 11"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU10"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="13">
        <location>
            <begin position="84"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="266"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="564"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9501566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="596" mass="68902" checksum="F2EE8ADBA7E7F59C" modified="2023-02-22" version="1">MAETINGDEMNNCNKQKMIESSPVAKKTSACIYHNPCLGGNNMMMNGVNVGSNNCLEDDHCSQEIIKLIKESLNYETGDHYTFIVFGASGDLATKKIYPALWALYRDESMPLKTGIVGYARSSMTIQKLYEHIGRHIKLRDEDERELFQQFLLHNFYVQGEYDDDNGFIKLMKHVQELEDNANGLHANRLFYLALPPNIFESTTKLIKQHCWNTKGWKRIIIEKPFGYDYDSSQQLSRHLQSLYDEDEIYRIDHYLGKEMVQNLIVLRFGNRIFAPIWNHEHISSIQITFKEPFGTMGRGGYFDRFGIIRDVMQNHLLQILCLVAMEKPVSTNAEDIRDEKVKVLRAMRTLSLDDIVLGQYIGNPNLDGEGRLSYRDDPTVPNESLTATFALARCQINNERWDGVPFFLRCGKALNERKTEIRIQFCDVPDNIFHDQCTRNELVIRIQPNEAVYIKFMTKEPGMTFRLSETELDLTYQNRYKDSRLPDAYERLLMDVFGGSQMHFVRPDELSEAWRIFTPLLHEIEMKKIVPAPYYYGTCGCKQADDFCVANGFKFDGTYTWPQSSRSSSSTTKIKKTSNIKTNDDDDDLNKKNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUW7</accession>
    <name>A0A922HUW7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUW7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="118" mass="14159" checksum="9DB3C234CAD1299E" modified="2023-02-22" version="1">MSEEIILNELHRFLRDVNHELLKLKELHNIVEADRILYNENRQQLDECLNRSCALFQLWTPLDRMIYQIDNPEYEIINIQRSINRKLRKIFRLTQAINGVLAESLLMLTAQVQTQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV32</accession>
    <name>A0A922HV32_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV32"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="189" mass="21271" checksum="2CCF5071C8DA4454" modified="2023-02-22" version="1">MISDCSSSPSSSTSSWRLYSMDKINSSIANNKTDKMIISINNIWPKMNNENRQRRSIINDDGQNDDNHVIGGGQLPQLRRLQSTSESSSSSTASLMKTSIAINRCSPKTFETCLSMMQEVMENSSLAFPINSRDLDITCRKLKSGDYCAEKYIRSCAGNRQRHLYQDIVQGSKNVIRLLCQQGRTQQCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV99</accession>
    <name>A0A922HV99_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoporin Nup43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NUP43</name>
        <name evidence="6" type="ORF">DERF_010574</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV99"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22652">
        <property type="entry name" value="NUCLEOPORIN NUP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22652:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9505802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="327" mass="37499" checksum="7A4012D12A620DFF" modified="2023-02-22" version="1">MMMMNIEYVSCKISAICWLHDDQFIRQSIDSNELFWLCGTHLSASKNFLTIYSKQEPINDQQRAGIVQLKNFRQLVNANVVGLANYDKRSSFYSLSNGQISLLQYDRESGFQTVHDWFNDDISDHKTTAIIVNNQSELISCGLDGRLMFFDIHSRITSKSRPLTLNSLHCMDKISDNEFICGTTSGHLKIFDRRNENVVLNMANEMSIITAVKRNINNPHIVACGNDLGLLYIWDLRNSGHRPMQPISVHGAEINCLKYIPNERNTIMTSSLDGQLIKWNISNDFEIDTVEAIIDNKKNTYPINCFDIYKNQIVFADDNEVLYLTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVR4</accession>
    <name>A0A922HVR4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exosome RNA helicase MTR4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SKIV2L2_5</name>
        <name evidence="6" type="ORF">DERF_009124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVR4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent RNA helicase Ski2/MTR4 C-terminal" evidence="5">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9510603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="167" mass="19421" checksum="50AC2E1F666AC16D" modified="2023-02-22" version="1">MRQTKEMMKKITSSSLIDELKCRKRVLRRLDYCTPEDVILIKGRVALKLLGFADELLLTEMLFDGFFNDLNVYQIAALLSCMRTEILPKLSEELSKPLKTMQEFAKKIATVSKETKLEIDEKVYIEKFRPNLMDVIYSWTKGKSFSEISKMTDAFEGSIIRCMRQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVW7</accession>
    <name>A0A922HVW7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVW7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="418" mass="48900" checksum="259A4BC581374350" modified="2023-02-22" version="1" fragment="single">MWSLDLVIHSLGCVYLYTYNEMQTEIYETRPLNLHKSISLYKKESAKLSKKKYKSPYGIKRKSCFDGLGVNIFQISPPDPFHDIVEWFEPRISQILLKSASVSRTQIKNKIQQINWINGPVKVKEDFSLKGKGTQKFEFLVRMMEIFPEWIEFPPEIYLSLRKCRLQFHITQKAISSVHEAHKNIFELDSKNQKLQNFMTKFVNSIYLQKKFSENLPTYVKSEELKLTNGKKYHYIGIEKILKTHIIDDNLIRNIFDENQENLSEYVRKNGYQNKLRIVLSGDDFGVSNPIGGAERKLFALYMDTDNAKIYNTKANQLPLVLLCERSHITDLNELFSPVKRDLKRLMDNGITVQYNGIERKLEICLAYVLADNLGVCEMLGMKRNFSKGFICRYCGLTYNEMQTEIYETRSLNLHKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW56</accession>
    <name>A0A922HW56_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_010949</name>
        <name evidence="10" type="ORF">HUG17_9478</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7642787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW56"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02049">
        <property type="entry name" value="PROTEINF36A"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7642787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9506207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="114" mass="12851" checksum="C4F2B163A53492FF" modified="2023-02-22" version="1">MTIDENVIEGLQDDQDGKQIMLFGTDITKIPCFKNSLLTGIYAGFGCGIASFLATSRVLQSTNISILSFVLVTYGYWFNCRIKWAKDNFNCRQAEGTFAEEIESIKSRKKKMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWI9</accession>
    <name>A0A922HWI9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">limulus clotting factor C</fullName>
            <ecNumber evidence="13">3.4.21.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">KLKB1</name>
        <name evidence="17" type="ORF">DERF_009336</name>
        <name evidence="16" type="ORF">HUG17_7268</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Selective cleavage of 103-Arg-|-Ser-104 and 124-Ile-|-Ile-125 bonds in Limulus clotting factor B to form activated factor B. Cleavage of -Pro-Arg-|-Xaa- bonds in synthetic substrates.</text>
            <dbReference type="EC" id="3.4.21.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.84" evidence="13"/>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWI9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042381">
        <property type="term" value="P:hemolymph coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051487">
        <property type="entry name" value="Ser/Thr_Proteases_Immune/Dev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24256">
        <property type="entry name" value="TRYPTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0353">Hemolymph clotting</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324687" description="limulus clotting factor C" evidence="14">
        <location>
            <begin position="23"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="15">
        <location>
            <begin position="54"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7637062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9510836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="298" mass="33820" checksum="8EA5705D47ED051C" modified="2023-02-22" version="1">MKFLIIFLCLALGQFITINCSGLELVQPGQSSVRSDPSKLRICNSDFAIDLKRIYGGEDAKPMEFPYQASLQVRYLNSHVCGATLITNRWILCAAHCFSRNSYPYSWQIKLGEHDLRKKDSTERLLKVDKIIIHKKYDRNNQLYDIALLRLEKPIDFSRERHLKTICLAKETDVAKNNYECVATGWGRGNKGRVVTDVLQKLPQPVHNSTTCQQIWKGVGWPITRNHICIGDLRGGKGVCNGDSGGPIQCRLKNGDWVQFGIASWTISDCVSRNFAAVFTSVSGYRNWIIETIRKNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWK7</accession>
    <name>A0A922HWK7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myosin light polypeptide 6</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Nonmuscle myosin essential light chain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MYL6_1</name>
        <name evidence="5" type="ORF">DERF_009367</name>
        <name evidence="4" type="ORF">HUG17_7296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWK7"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF49">
        <property type="entry name" value="FI08416P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7637090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9510866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="155" mass="17657" checksum="1EFFF1B89A37D244" modified="2023-02-22" version="1">MGGHTTDHVQYDQAQLEEIFQIFDTKGDGCIAIDQIGEVLRAMGQNPTEADIHRCCEPLREQQRDQRITFEVFMPIYQQISKNKDRYSFDDIVEGLRHFDTDGSGTIGAAELRHLLTALGEKLTEDEVEQLIDSTMIDDEGRINYETFVKAIMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWU6</accession>
    <name>A0A922HWU6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium voltage-gated channel sub A member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">KCNA2</name>
        <name evidence="16" type="ORF">DERF_011832</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWU6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000002">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000028">
        <property type="entry name" value="Potassium voltage-gated channel subfamily a member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000053">
        <property type="entry name" value="potassium voltage-gated channel subfamily A member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003972">
        <property type="entry name" value="K_chnl_volt-dep_Kv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF113">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01496">
        <property type="entry name" value="SHAKERCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="15">
        <location>
            <begin position="218"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="645"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="810"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="882"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1014"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="679"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="747"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="810"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="842"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="892"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="917"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="950"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="976"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1027"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9507133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1069" mass="119023" checksum="FD4E527B1E348DFE" modified="2023-02-22" version="1">MAFCSAYGTYGLGVPGTPQYASDRSNYLPGSSIGPGQTGGMIPMFLQAPPPDRATGSSSGVGGGGGGVGSSTFASFHHHHHHLHPNQQHIHQQSQQPHQQHQHQHPLSSSSSNIVQQQLQLTARSSSIQNLVPSIPKSAQDDSGGVGGIGGGASGGMGIGGLGGMAGDYDPYHHPGGLQYHEDNELLAGCEQQQDLLQLAGGFGSRFEPLLHRHDLCERVTINISGLVFETQLRTLQQFPNTLLGDPAKRIRYYDPHTNEYFFDRNRQVFDAILYYYQSGGRLRRPVNVPLDIFAEEVKFFELGEAAFNKFREDEGFVKEKEKPLPKNEFKRKIWLLFEYPESSQWARVVAIISVVIIILSILIFCLETLPEYKHYKIFNTTTNMTRVVEDEVPSYTEPFFIIETICIIWFSIEILIRFFACPSKITFLKDIMNAIDFFAIVPYFVTLATMIAKQPEDDELQKLQMLHGNTDSKSQSSSLAILRVIRLVRVFRIFKLSRHSKGLQILGMTLKASMKELALLIFFLLIGVVLFSSAVYYAEADSERSNFKSIPDAFWWAVVTMTTVGYGDMRPVCVWGKFVGSLCAIAGVLTIALPVPVIVSNFNYFYHRENDQEDLESTNFNHVRCCPYLPGYVGTNRLRRTSYSDSNITHNNNDDDEDDDDDDGDIIGDIDGIRINDNDDDDDGGNDKNNDDDDDDNDHHNSDNHHHHHHYTSKNDLIDTGNTKQQQQQQLKKPFYHRSLSSKSTQQFQDNSNDQQQQQQPLLLMASNTIKSPSSLSSSSLSNRFPTKPTIAETCDYEKQLQLMIQRTNSVRHASSSNSNRRRSSNQSTSPLSAATSSSAIGTYQQHQNHPYSYSPYPTTMFPTTISSPIPITAATIATTTGGGGIIIDPNGSSTLRSPISETGGINLTRTASFHRQQSQQQQQQQSYRRRSSTRSPQSNYSSPESPTKNKLNNTNFLNLITISNTSSSSSSSPPLLPPGCQAPPSPSLRLHYIDNNRNLRSPSIEKIIPTTTKQSITLTPPQPQQPSSTATTTTTTTATKSAKKSRVYLKAKHTMINIIAFMFSIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXL9</accession>
    <name>A0A922HXL9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXL9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="152" mass="17496" checksum="842DE9DF8CC2E25D" modified="2023-02-22" version="1">MNIKGAAAAAQLLHLIPSGDEDYLAMKNRSICSEEDRLLFEDSLMQSMYRRLNQPIPVSHRSVAAFREIPFNALKHSIITFAFLQAFLQNDHLTVINRNWLTISLANLVRLILRKNQITEIGLLAFDNLRSLRFLDLRHNHLGIFLMVHFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXT0</accession>
    <name>A0A922HXT0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXT0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7573" checksum="A0C446F1CA2CE2A7" modified="2023-02-22" version="1">MLIAAAIRQTNITLNMTKALNLKKKDHICSPNSHHFVKTFICPCNNNGHFIVSKKKYVHFRVQNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXV7</accession>
    <name>A0A922HXV7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ZDHHC14_2</name>
        <name evidence="13" type="ORF">DERF_010177</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXV7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="203"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="422"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="631"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="698"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="747"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9511743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="768" mass="86549" checksum="BFD744C2FA481DAA" modified="2023-02-22" version="1">MTQNNNKSSSSTSPPISSTVAAAAAMGVVINNNDNNTMTTTTTTTTNNNNNNNNNNSSPTIIATTAASTSMATTNVRRVRRYRIFPGRNRFFCDGRIIMAKQISVFYFTVTLLVGTCVSFFIFDSPYLSNKISPLVPIVAACLFLFVLFSLFRTSFTDPGILPRATPAEAADVEQQIVPNQSNSSTMRPPPRTKEVMINNQTIKLKYCFTCKIFRPPRASHCSLCDNCVERFDHHCPWVGNCVGKRNYRFFYMFIVSLAFLCIYVFSCIITHFILLSKTMTFVEAVKQSPVSVVEMIICFFSVWSILGLAGFHTYLIMSNLTTNEDIKGSFSKRNHVSVTNPYSLGSIFRNCYSILCSPIGPSLIHRRSYVYCEESIITTTASNNNSNHQTQSPQSSKQSQSIRFPGPVAYPLQPTAAFISGQQQQQQQLQAPGMASYYHHHQQQQQQQQPPSMNKSPQIISHQLKQQSNGQSQYYVPMMKNMSISQQLHSDLHGQVYLGHDIDELDKQQQQQQQRYGLQPNYYHQQQQPQPINDNSHNSIVMMAEPYQIDHHNHHHETANAIDSLNYPHSTCQQACYYQKQSSSSPSIRQQTNIAQLQQQSDYHNYTTTMVIDPYYPNLLKKNNSSSIIINDNDDNDDHDHNNHDYCNYPSTQTQSQQWNNNNNNNNNNNSQISKSTTATSCSHHHHHHHHHHQHHPSNSSKSSTGSSVGGGGSITGTYQSRSNNHQQKRSQGTTTTVKGGNVVGQTINTRSQQIKSQSNSNDNGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ29</accession>
    <name>A0A922HZ29_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-processing factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PRP6 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">U5 snRNP-associated 102 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PRPF6</name>
        <name evidence="15" type="ORF">DERF_008007</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000054">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000058">
        <property type="entry name" value="Pre-mRNA processing factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:003529">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23774">
        <property type="entry name" value="TPR_GEMI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Gem-associated protein 5 TPR" evidence="14">
        <location>
            <begin position="1633"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="13">
        <location>
            <begin position="1817"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="2492"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="580"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1827"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1899"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="580"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1831"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1858"/>
            <end position="1871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9517329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2724" mass="312007" checksum="C1AB35EEBF9DEB18" modified="2023-02-22" version="1">MSKISYSVMKKLKLDRLLKRQANFDQVIVFDEEFELKYNHHGNRNYWLTFVDFCSTYKYDPNGSCLKTATYKDIVNKVNEWLLQLPQYRHRDRLTPGQPIWTIINCETLYAKISISFSENGEITRKRVMQFSKWPLNDELFMNLYCEGNTMTQNFEQIFNGRYIVVLLRVWMTKQPYFPLMLILPPPTIAIKDYWPQKITVDDIVNHNHNNNNEHKKVKKTAEFRRKLRRTLSIENSSGGSSSSSSHHHHHNHSEPKECLEKIQEITKRINGDIISKQIHGRILNVITFPCYYNKENHLNVSDEPIQVGGKIPNGHIVNMIRVFYVWKPICEYDNEISTQIPKELIGIIDFVPRCISGGGFIKYPRFETQTDIIDKATMWMTKNSQYKFLNFSSIDIKLKSMTSIDSGEMTFARNTGDFVRIIRLCYLKPYLPNNYDSCNENISDIINWKPSAPIYLQCKNIVSINNSLKELQQQMNDYLLKARKNDYHNSANYQYYTGGEIERWRFICVDSVAIFISNISNSGDSRNRRHIIMADCDKSFHAITISSNHASMNRNMLNGINIFYDIGLYGRRPKSNMTLSLNDTDNNDKLNGNSVSQSDNIDNSNMKNGDGDHKRERQKNRSDSALTSATTTTTDQTEENDLLKIQNEIIVDENVDEQEIENPKVEFSFGTFWNWFLPSCSDVWSSSSSLNPEIFLAYGAKSFLFLADIIVQKSKKRSTNNDTKKWKIHYREIVNVFGTKAKSQHFDVFRSNSSYITTVVFDKTFSMIKHGSSKNMNQKIYATSCAMIFLGNSDGVGALYDCHRRITLLQNLPFSAISRQCCKTVAQKKILSAAWLHYQSEGPIVYYSLDTHIIVWKVKKNEVKILHDNNEDCQNSRFNSGQLQIACLASLPAECCPSSSDKNEHKLAIGYMGGKIVIIGFDSMTGDQTTSLTIFAENGHNDDICSLSFSSYSLSSHQSYRQGLLCSVSRDSVLKVWSCSNQNEIAEHRIVSNYHGSNQKASGSSQTNTANWFTAGFMPRSCVKHSNVAYEIVLTNSSGDLLTFTLPEKGLNSKLRIGKTNRTFQSKTVSKNQPMNHTFIIFSIAMDLEHKIAITNSLDYKLILWNLSTRTSETVFYSFSNGALAIDCCQSDKRIAIAFGSNIFVLDFTREATTNDDEDDDNHHYDIQVQRLQLSSKTRFFNVIWNRKYYERLGRLIIATLDGELIHYDLNSKDIVFKSSKVNTRDTSKIYSIIWLDTLLLDENQNDHQSSPVVLTLHQSGKILVNYLSNNNDNNSHRAQENFDKYLVGVPENQKIKRTALLTSDEQKYLLMGNDDGTVDVFCRIVEPPVDDKAFRHLYRFRSFNRPCLSIEYCSRTNYLAITALHEKYINCYRLDDLDNNTLPCVSSSNIDGEDDDNDDSKLVVKTVPIKCRLKGHEDRVSFTCWSPFNRIEDIDEKILLASASYDTTCIIWNIAKRIPLKRFFGHKSLIYSIKWCHFNADFLFSGSEDNFFFWNWTIQPDFSNATDKQNVKINSLRSLLENNINNGEDSGETTNDAIANVPDEASFDSTISSLSSEISKLKNLANTKTLGNKSSSSSLSVPIKALFSLNNQIENNSSKYEHLEDIKWLIQLKKSTTAVTIPPNKLDRILLYGQFEHIERLLELEIENHKKNKNLEGQYVLSLFLNARSCVEKLLEQNECDPILAMIASSFSRKLYENCIRNILGESSSSNNSRVQQIQLNSKMKWTNYSKELCALIRICCLNEFHVSIDSLLAQNLFREAIILSVIHLASDTFVNKLFYQWHEYRLKQNNYEGAIKCLISGGHYCQLNKCKNFATGFTTRSDIGPARDATDVPDDRHALSKSKLASKKPGKDNEQDIEDDEEDLNDANYDEFNGYGGSLFSKDPYDKDDEEADRIYDSIDKRMDEKRKEYREKKLRRELEQYRQERPKIQQQFSDLKRDLARISADEWNSIPDVGDARNKKMRNPRAEKFTPVPDSILAHNVSLSNETVTSIDPLSGLKTVISGTSTGLLSSAPSHLDLKKIGQARNTLMDIKLNQASDSVSGQTVVDPKGYLTDLQSMIPSVGADISDIKKARLLLKSVRETNPNHAPAWIASARLEEITGKLQTARNLIMKGCEQCENSEDIWIEAARLQPPDLAKSVIAQGVRKLGNSSVRLWIKAAELEKEVKAKKKIFRKALEHIPNSVRLWKEAVELEEPEDARILLTRAVECCPTSVDLWLALARLEVYENARKVLNKARENIPTDKQIWFTAAKLEEAQGNLSMVQKIIDRALNSLQANGVEINREHWVQDAIETEKSGSKATAQAIVKSVIDFGIDEEDREHGWLEDAENLANSEAFECARAVYANALKVFPKNENIWLQAAFFEKNHGTKESLESLLELAVVNCPQAEVLWLMAAKSKWLGGDVQASRQILSRAFDVNQNKEEIWLAAVKLESENAEYDRARKILEKAREKNSTPRVYMKSAKLEWQLGNLSRAIELLEMAINHWDDYPKIWMMLGQIHQQTGRTNEAREIYQRGLKSNNSNVALWILLARLEESEGALIKARSVLEKGRLKNPKNDLLWLEAVRVEIRAGNKEIALPMLSKALQECPQSGMLWAEAIFMENRQQRKSRSVDALKRCEHDVHVLLACSLLFWCERKMTKAREWFKRTLKLDPDLGDAWAYAYKFEILHGSQEQQMELKKRCIQAEPRHGEHWCQVSKDIKNWRLKIGDILEIVANELPIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZD2</accession>
    <name>A0A922HZD2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZD2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="348" mass="41030" checksum="8A11AFB3060100D3" modified="2023-02-22" version="1">MAIKAAVRIQRQQIVPEQQFYGEDFILIDHHNCHHDGQQQINTGNRNSFICRIIELEKTIFCLMFHLIETYYRPIINQLPLSNNKNSNKSTIDINRQLDRTTTGKEWYCEYRMPSKRIYGLQKAYKRQFDKKFDRAAILLSDNCYLQFHRNHIDWQLVFAPISGFPCCRQSNTTLAKQLDFDSLFDIEDAITQSAYLLANARQHSQLIDNLILNNAETNNGSNDIENDGKQPYRPSSQYELIMKDDYDDFTRLVKMIEKLVKIKSEQMKECLMISEHQNKPKESLGLLDAWLFFKRKSRSFDQTENEHCHEYDVSQVQNLIEDLRKEIASWEELIDVINILKCSPSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZY0</accession>
    <name>A0A922HZY0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZY0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052729">
        <property type="entry name" value="Acyl/Acetyltrans_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH/HolE_GNAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47237:SF1">
        <property type="entry name" value="SLL0310 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="344" mass="39081" checksum="E2EF1F7B9981A757" modified="2023-02-22" version="1">MEHHNLSSLMTTKNDKIRFRVRQMTNEDVPTVLEIWAKNNLHEGTHTIQSFMIQDPEGFIVAEQINDSDDLDGNPSQTIGNASIIGMCVGIFVHPTIAFIGMYGVQPELHGRGIGLAMWRKMLDHVGSLNAGLYAVPEHLTMYRDRAGFHQPDDRMLIIYESDESDQLNVDILVPSIPETKIQRITTEWYSKVIDYDAQVHGYIRAKLLPHVFTEEGSIAFVASDTTGQRIFGYGCMRTNNIGKAMIGPLYANNGAVAELLMRYLFSRLSTPFGKGLLYMTLDSNHGGQLIADKLCLKQQEKIQRFFRFQPYEGADWNREFKSFDFLSNITLLASSKLNRWRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0F5</accession>
    <name>A0A922I0F5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">EIF3I</name>
        <name evidence="10" type="ORF">DERF_007476</name>
        <name evidence="9" type="ORF">HUG17_1854</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0F5"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7646316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9516757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="328" mass="36897" checksum="334A90257C015089" modified="2023-02-22" version="1">MKPLSLNGHERSITKIRYNLEGDLLFSSSKDNTPNVWYTINGERLGTFDGHTGAVWCIDPKWDSTKVTTGSGDCTLCIWDCETGGRLNVVKTETSVRSALFSYSGHLILYSTDQQMNKPAELNIIDTRIVDENDGITNVFSFTLPSKSKALSSLWGMLDQSFICGMENGKLAKWDLRQPDDPLLETEPHKAQINDLQYNKDQTLFVSASKDNTAKLFDPFTLEHMKTYVTERPVNSASISPIFDHVAVGGGQEAMEVTRTASESGKFESRFFHLIFEEEFARLKGHFGPIQSLAFHPDGRSFATGAEDGYIRIQSFDDGYFNFKMEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0N4</accession>
    <name>A0A922I0N4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrator complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">INTS4</name>
        <name evidence="6" type="ORF">DERF_007594</name>
        <name evidence="5" type="ORF">HUG17_1959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0N4"/>
    <dbReference type="OrthoDB" id="18190at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056235">
        <property type="entry name" value="INTS4_8HBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057412">
        <property type="entry name" value="INTS4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20938:SF0">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24493">
        <property type="entry name" value="INTS4_8HBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25458">
        <property type="entry name" value="INTS4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTS4 8 helical bundle" evidence="3">
        <location>
            <begin position="467"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Integrator complex subunit 4/Protein SIEL C-terminal Ig-like" evidence="4">
        <location>
            <begin position="690"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7646421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9516877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="844" mass="96201" checksum="5F9CD76FB88C97A8" modified="2023-02-22" version="1">MSVEFPDFLHSIQKRLQQAENNYLTINECLINLSNLITSHDSTALQNFQSEVGSIIKILRDFSHYHDPRVRSTALSSLVILHENNIELDISLYGEFNDLLNDEYETARITAMRLIQLLSCQYKDCLVCLEDGEQIRIVDDAFAKICSMMNDYSIAVRVEAAKLLGKFNDISLNFLHQTLDKKLMSDLRKKKSAHQRHRETLEAGEWSSGRKWTDDSASEVIYPETVTLMSIGSCGAFIHGLEDEFYDVRMASLESLCKLAQIYPTFANQSLDFLVDMFNDEIQEIRLKAIQCLTKISGKNITLREDQIDIILAVLEDYSIGIREALHLMLSNCKLASNVALRSTINSLKENLKRYPCDRESIWNCFRKLGQNNVYLTLSLISELLLTHPFFRLTDNPLDDPEYVAILILIFNAAQDCPIMIELLEKHTRKHYIYLKGSYPHLVPSLSHLFDKTANNDLKVDMENCDQFFLKIFQRLHNLVRVDRCSVNVQMSALSNAISDLHKLSLLHSSIEPACKFYSTYLQCQISLRKIVSNSNWINTFLMSALQSSVFRSSLQQLLSSTFSMLNCFHRLQPKHIIAIQQTRIKAMALQLIAIIHGSNVSALGLCDAFLSEMTTLKKLSAEHNVQLNEIINNMFDAIASLNQPRPGTVGRILQPIFLNSSTSKICDLSNILDDNVLQDFKKITMTKAEILEPIEQMNSSLKFTAGLVLEVPFTANLEHVKDIKNIRIKIQYPDQQIQLIQPKLNEFRIKTEREDDINDYKLVTKICISSYGVWSGPSLIEINLLLDFRDISSSSLATTQIYSSLLTKSSGIKSTRSEDNLVIEICKPVKLMIHPTKPKRCVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0U2</accession>
    <name>A0A922I0U2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_007628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0U2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9516915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="335" mass="38265" checksum="5F8CB9EDB3FB085F" modified="2023-02-22" version="1">MDDSTFYYGLSFLLLLISFIALFWSFFSALFLPTQWLTPVGKVILITGCDSGIGLEAAKYLHSKGSIIIATVLSISSPGALELKTKLNDDRICLIELDLDDITDSDRPIKKIQKFLDDRKYELHALINNAGICVVGEFDFQTFKQIEKQINVNFLGTINLIKYLLPIIIKSQGRIINLSSVNAIVPFPGVSVYSATKKAIETFTESLSIELKKFNIKTVCLRLGDYAKLTNIMVNHKKIMQDQLESFDESKRQLYDGYFQKYHESVMKNFGMFSPKSFASSSLFDDFEEAVYAVNPRTHIISAKFTYKLLIYFLYYVPFNIRCFLFNKFNSVTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1U0</accession>
    <name>A0A922I1U0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/arginine repetitive matrix protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SRRM2_1</name>
        <name evidence="9" type="ORF">DERF_007246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1U0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21373">
        <property type="entry name" value="cwf21_SRRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9516511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="132" mass="15764" checksum="B0D6053608196DC3" modified="2023-02-22" version="1">MYNGIGLQTARGSGTNGYVQRNLSFVHVSKPKIDYKTEEEIRRFESEYLKAPNREILEHHRKRKIEVQCLELEEKLEKKGLSEDEIQKRVDEYRQELQKKMLKALENRQEFIEEILNSKGTEPRILSKIRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I211</accession>
    <name>A0A922I211_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I211"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="7030" checksum="C46D68BC2477A4F1" modified="2023-02-22" version="1">MKQQQVNPNDDDDDFRPIIGLDLTSSYSCHQQFLIDRSSYTMWPKRQLLYDNDDDDDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2T3</accession>
    <name>A0A922I2T3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2T3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="66" mass="7413" checksum="86150D6F6428D362" modified="2023-02-22" version="1">MGNENVKIESQFDGETETKRIDSPATAISQVPVPVSRTISVYDGKVKTLNFRLFSVLYVEDGIFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2V5</accession>
    <name>A0A922I2V5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2V5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9521011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="124" mass="13502" checksum="851B365E824B417C" modified="2023-02-22" version="1">MSLSVTGYAFTLCKCLHCVLALGINLAFNATKLSRAFILIFSTNITIYSSSSKVEAAYKETHSVKKESSSTNNNNQVSTMENSPSDNDKLIDVPTFIGSNASAVDQFGIQSAFYELNCIKLNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2V7</accession>
    <name>A0A922I2V7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005061</name>
        <name evidence="1" type="ORF">DERF_008181</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2V7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="6637" checksum="9A5A833C84F663CB" modified="2023-02-22" version="1">MIIHSGYGLLPVSVAFERPDTSCHLPYGSQLIHAGSFLLLGQSAKSCASAQYGHTGCGSRQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I369</accession>
    <name>A0A922I369_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">B3GALT1_3</name>
        <name evidence="11" type="ORF">DERF_008419</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I369"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF349">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE BRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9517787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="282" mass="33476" checksum="236882B472D47BEF" modified="2023-02-22" version="1">MTPGFFQRIQYEFQSIRCEPIVYHNPNHRHQHRHQSLIHWIKFRLRGNRSRLLLITCVTIIILLLMYIGGIFVHPFETIFDGENFHYPLYMKDFRYFIENVKQNSANNALKPIHNYSYDYHLNPKFKCQQNFDNMGTNSTSSLYSNNPITLLLVIKSATCNFLLRNIIRQTWGNEQRFSDVQIRTVFMLGKCSSSVNQFRCPNTFHHYPNIVFTKKSQKFRSIFAFNQTVDCQQLIDIENQFYNDLVQADFIDSYYNNTKKNYGLNTMDSTELPSSAVYFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4W3</accession>
    <name>A0A922I4W3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_004936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4W3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="220"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="265"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
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            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9521263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1047" mass="123320" checksum="5E0C6F5D29D49BD7" modified="2023-02-22" version="1">MSISEIYSSIRKICDKVDYDNNANCFNKASGQLDYILTNDLDLSKKFSESFVPAFEREIIRTKKSLDDAQRFKQFSSLLKNLTDISFTNKAMNNINMAIISTPMEEDNLLFHCFSQRSTLHSNQDDYESSLKDLDHALGIRLSYTLVERKVDILNRLNRSSEAYRMVADIIDENEKILTSDKLKQYKKLKKQLRKFKSPHEIDNGQQSSMVKCLDVKIDQRVRIKKIQCDRYDFQTNTDIAANTEILSEQPMVISFTADFLHDYCHNCRKKVTNTFWPCFYCTEVVFCTKKCAEQALQAFHQHECGLLTTMRDKLGNQSITVYRDFIQLPHLNLALHRDELQTFSLQSCLEQLAQQTTQGLDISKANQWFFISQRELYQRIVRRKPWRRSVELCNAIILFMIYCYKMNIDIQQFEQKELIEIIEHFAISIVRTQLNEYSWQQKEHQDRQQIASFQCLFGSHINHECDPNAEWTFDGQKFVVKTIKNIAANESITITYGVPKEYSLFKRQRYLQNLYIMCACSRCLEETRDSCFAIRCENCNGPIPFDMDEFLNDWCMICERRYESPSIMTLVQKQFQTLQRAIRLISSINNQKAWLGNIEELMGSLASYVYLESQLFICLVSKLCDRYIELEMWPQAIEWYQWFVNVAALHIAKNKENDIIYYYNLKKWSNAYLNYLEQNVQAGKTNITIDYLQTAIYLFAEQRKILESLRQMNRFEVIDSIQLKNMTRSLAQDLQCKDYRLKLVCMEICKAKEDTLANGDEIVKDLSVEKIEFDKLKPDMYNYAHELSASISLEKRIEKDKHIPNSYHCHLIHIIGSYHYRMLFFVTNDDIDSERRYKLVKMDFTDSTIFGPNAINLLHSNLIRSQQLTHIGWFSDHFRWEEKIQCFNNRWTFCDKIFIAKCKPNSIRAIYQFVPFKIESNVRHLYFSVRATAEQLVEQSNDGFYGMLALIEHVDGTDEIIRLKFRYESESWSLRVEDYRSTKTIKSVTIMLACYGYSGIASFTDVRLTSESAGLDPLFSAYDICSWCSFQPNDHQVKEIESIIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5F5</accession>
    <name>A0A922I5F5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Krueppel-like factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KLF5_2</name>
        <name evidence="2" type="ORF">DERF_005324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5F5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="787"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="850" mass="93728" checksum="C074D694319F98EE" modified="2023-02-22" version="1">MSILYDHLFSSSSSLQNYSTNNSNSNNNNNNNNSKLMNKMMLMTMMDNHSIHHHHNNHHYHNNQTTTTTTTTTPPSSSPPPIINNNDTIITTQSSSSSLSPYFINGNNLPIIKSEINESSSSASFSPLSYRSSITDEADQIVPDCTATATTIMTMTNNRHNQLQHHQQQHPYHHHHIYNHQHTNNNHHYNHHHHHHHPHQHHHFNPYQQTHHQHHHHPYNASISPNSLWSSTISPTTTMNNIIEEKQPTISLQQQQQQQQTLSSFHHHHHPQQQQQQPINYIEQSSSKSSSSSSPKSIDSNYNNHFNDNNNDNQQQQQQQKSSLSISISVNMDHRSTNNNSNVGYQQQQQQQQQQPSTFATATTTTTNTPDSMHFKAQILDNANIESSATYIYDNNNFMQPPLPPPTTVTNNMMIMSPSTAIMNPILSIESNPSSSYEQFVQTIGNQHHHHHHNHLNQQQHQQSLMMNGNPRTTTTTSSSSSYPLSLSSSSSITNNITGYGIATNWNNDTGSTDTTIYQHHHHQQQHYPIEASTSSSSSSDISGYNQQQYGSSSFGTTITTTSMYTNTFSTPTSSIKSQLSLSSSSSSSSSPSTTTTTTSRYMPPTPPSSEPGSPGSSASSSSSSTSTSTTTQTTNNHNQQSIHHQLNKSTSPSLSVHTINNSNQTISPAYHMDNNCVKNTVVLAQFSSSSSSSPSQVSSIPSSSTSRNSSSTNTTTTTTEAAAAKITTKTTITEKSKTVHLNRNGTTAAIRTTIVNGNQRQQGTGQSSSSSSVKALSHRMFGAGTSGILSTTATSGSSSSSSTNGVPGSRFNIENTSPTTIIITPQPRYNRRNNPELEKRRIHRCDYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6A2</accession>
    <name>A0A922I6A2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Polyprenal reductase</fullName>
            <ecNumber evidence="2 9">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SRD5A3_1</name>
        <name evidence="12" type="ORF">DERF_005158</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8 9">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="2 9"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6A2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160198">
        <property type="term" value="F:polyprenal reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102389">
        <property type="term" value="F:polyprenol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="206"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9521505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="356" mass="41331" checksum="2888D8F3EC821BC7" modified="2023-02-22" version="1">MAFQLSGKNDHPSSSTAAVPSAEQMQKESKKKLMHNIFYFGFIIAGLRFASSMLNDGSAIMMITLNTGLILFWNILSIGIIISGTITLNGLQSKRIPEFIRSLVLYGKFKSLKQQQSNDNDSMIKRWPTYYRLLSILDAIIRMLEVPKYWFRHFYIISFLINSALIIRMFCCSIQFETIILIGLQWLQSLRRLYETFYVSIYSGNTINLVHYIVGIFFYITIGLATFNDCHLVQSSNSSSSSSMIAVFIFFTSSAIQYQSHRILAKLRSSKAKQNNDYYIPRGGLFEYISCPHYMTEILIYICLWLQSSRSYLWSTMVMFVIANQTIASLMSYRWYRKRFNDRYPTTIKALIPFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6E6</accession>
    <name>A0A922I6E6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6E6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="130" mass="14891" checksum="AC7C09A238ED0316" modified="2023-02-22" version="1">MDGMIIQDNELPDGNFKLVDSLVALGGRLDGINVFDMMEQTINDNKTIKILKKKQEKNTNDKLRCVRCWYVYLLDYVLRCIHWNNMIIGGGRFCISRNGSQIRIRSAMANQGIQNGNTNRPGKNGIDQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7S1</accession>
    <name>A0A922I7S1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TAF11_1</name>
        <name evidence="7" type="ORF">DERF_000622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7S1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9526546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="183" mass="21314" checksum="6DD3CDBF360EAD76" modified="2023-02-22" version="1">MDEMHTTAPMASMTWNDKMMILLENFNHEQFSRYEMCRRSKFSKSVMKKFIRSITDVMINDKTAIALAGIAKVYVGELIETDYQQKIGENGPLTPKHLRESFRQLNRNNQRRVSSPSLSEFHVFDSSVCHHENKANKTNKTDTKKKSAYKISLNQSKSDNKCCEEQIMQNSCKHEQQQQKKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8C0</accession>
    <name>A0A922I8C0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_000304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8C0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005173">
        <property type="entry name" value="DMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF118">
        <property type="entry name" value="DM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03474">
        <property type="entry name" value="DMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="8">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="6">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="703"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9526205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="724" mass="79596" checksum="C49398ACB1979CEE" modified="2023-02-22" version="1">MLRMNPETQLANNNGDYNHRIPSPPLSNDEEDEEVEVDDRIQSTTMQIKSSSNIILDNEDELDDGDNVDDDGDVDDDDDDDEDNVDAENEISISKSVRNRRKSTKQIDNSSGLRKPKCARCRNHGMISWLKGHKRHCHFKDCRCAKCNLIAERQRIMAAQVALKRRQAAEDAIAIGLRAMATGAQAVNGYLPQGPIFGLEITEPETKRSKYCQDSTPPPEIKESEIAADIPIVSKSCVEKTKQPSPSITSKGNSNIGSNGKRNTIKAQSGKSSNVRCSKSDSTIINRQENEMIMADIVTPVNRAKLLDENLSLLTDVAEDYRSGRASPISTLTRLFPEQKLQVIELVWQATEQSMIKSIEHFLSIDEAAALKHNLMQKDHNLKNIITHQSMPQSLPYDYNKATAFYSHPSWNTHLVPPSISTASTLPMTAASISTRTTTTALPSLPLATPSPLLLSSHNTLPIHGNNNHHHHHLHSFPFNPMFNSPFFPFPMNTAAIPVSLLPPLPHSIDTGRNQHHHNDSCFNCDDSSTSFSSKTSNKIMPQHMMGSTSTLYGITPIVTKSNCNKLNMRSSHGSTSTSANDERIFNVLASTSPMIHSENSTTSPTSLSRSCGQLLTPVLPSIMMPMSHTSGSLLPLVADSSNSSPPLLSANTTTTNNLPSMMNHLLFDPFHRHLAHKAQLPKTTMMDSNSLADTFRSNRMHASASNNSDAVDLTKTVSSSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8K9</accession>
    <name>A0A922I8K9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat-containing protein 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">WDR54</name>
        <name evidence="3" type="ORF">DERF_000991</name>
        <name evidence="2" type="ORF">HUG17_4244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8K9"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049546">
        <property type="entry name" value="WDR54_beta_prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21031">
        <property type="entry name" value="WDR54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WD repeat-containing protein 54 beta-propeller" evidence="1">
        <location>
            <begin position="78"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="332" mass="37636" checksum="85A178C399F6F611" modified="2023-02-22" version="1">MYSQLNPIIIRLTTSACFDNLSIESSKDDKNTKLAVHDDRKMSVISIDNGANVIESSMIDLSNNGKFNTLQMIRLLRLQDKIYLISLSSKTLKIYSTDSGCTLLFDHNINDVDTKDLLAINSIERISKDVFCFVTQNRIRMFAINSSNCFVEKEFHQDLKSSTTSQIDKFISIGQSQFALFENLAKITIWKLNEKNLSFTRITAFNIHPNTKLTCIQVYKNLLLIGTVSGQIQIVNIKDGQLLGEIQAHIKCVTSMDVATNIGYLISGSEDSYARLFRLEQINENEFRAEFLQQFIAPNEMIFGTKFLNPNGSFLAISTFESNQIKIFKISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8M8</accession>
    <name>A0A922I8M8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Der f 1 allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_005079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8M8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037000113" description="Der f 1 allergen" evidence="3">
        <location>
            <begin position="22"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="5">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="118"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9521418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38269" checksum="4CF6777AF6DD6D18" modified="2023-02-22" version="1">MKFALTFVILLVFSIYHNNNASPTSIRTFEEFKRQFNKQYQSIEHEEIARKNFQETLRYVQANQDKAVINEYADLSAEEFADGYLMNVQDVQDLEAEMDAHKEYFDDPDCELHGDFNPPKEFDLRPHLTPIKKQIKNCGCCWALSTISCVETAYLAQKNVSLQLSTQELVNCAKEHGCKKGTVLDGIEYIMANGTTTEEACPFISEESTCDQSKKPRYEISNWCYFKPVEDDIRKNLVLRRTSVSVSMNIKNLKAFVHYDGSFVIRENSFPSIGNKSYHAVNIVGFGTKDDIDHWIVRNSWGEKWGDKGYFYVERDINLWGIKDWAFTTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8U0</accession>
    <name>A0A922I8U0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication factor A protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RFA1</name>
        <name evidence="2" type="ORF">DERF_000559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8U0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication factor A C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="106" mass="12902" checksum="F6B115AF62540B11" modified="2023-02-22" version="1">MMLNIEIADWSGSIWLVAFYDLCEILLQKSIEELVKLYQDNIRCYRKLLIQKLLYHTFNFRIKSRRELYEGEYRIRHILESVLPDDDDKSIHETYIKSIKFLNENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8W0</accession>
    <name>A0A922I8W0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">POMGNT1_1</name>
        <name evidence="22" type="ORF">DERF_000587</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">Derf</strain>
            <tissue evidence="22">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1-&gt;2)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54128"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:13802"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="ChEBI" id="CHEBI:138067"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with DAG1 (via O-linked mannose moiety). Interacts (via transmembrane domain) with FKTN; the interaction is direct and is required for normal location in Golgi membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8W0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047223">
        <property type="term" value="F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13937">
        <property type="entry name" value="PANDER_GnT-1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000038">
        <property type="entry name" value="protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052463">
        <property type="entry name" value="O-linked_mannose_GnT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039474">
        <property type="entry name" value="POMGNT1_PANDER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396:SF1">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52031">
        <property type="entry name" value="GG_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0430">Lectin</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="ILEI/PANDER" evidence="21">
        <location>
            <begin position="145"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF15711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KAH9526505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="714" mass="82119" checksum="BEDA90D2C4425C92" modified="2023-02-22" version="1">MCITRQNFGYFFLILCKFIFLVVLIATVIVNILFIIDTTNRLRNNQQTIFSQINPLADGGGASADSSATNFLSFDTSIVDGQQRTNFIPYDQSNNNIGDNDDKANKAGQIASRHLELEILSSQSRVYVMVDGTTILDDSDETKGRGIHVLVLHQSTGSIMAQRLFDTYSPHEDESMSLFLNLITDGRIIVFAIKDEGTFQMKQAARDLLKRMGSKRSHQIGWRDMWCFVVRKNTQDGDKSESSSNVFGEAYAKSPDFNSWAAPVMLQATVPLVPSDQSECKQWSDTEENRRRRSFCSRIEGYGSVCNCNDPAMIDFSSLSRVSHDEKSEYERISRVPVSIVASNRPQYLYRMLRTLLSARGCNPSMITIFIDGYFEEPLEVTKLFGLRGIQHTPIGIKNARISQHYKASLTATFNLFPDAEYAIILEEDLDVSPDFFSYFGQTMPLLEQDPSLYCVSAWNDQGYEHTSQDPSLLYRVETMPGLGWILSRKLYKDELETRWPTPEKLWDWDMWMRLPDIRHDRECIVPDVSRTYHFGSSGINMNSYFQDVYFKKHAFNTLPYVRMRNLDSLKKDNYERMIEKMIKAARLVDHSKDPCENDFIPSSLSSSSSLINLSWNDTDSYVNSGNNAAHHQTYVIYIKQMNSRDFQTWLHVAKCFRIWDLDARGYHKSMWRFFWHRHHVLVIGVPHSPYSHLKPANIMPISVNDTTQNPIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I953</accession>
    <name>A0A922I953_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Coiled-coil domain-containing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CCDC12</name>
        <name evidence="4" type="ORF">DERF_001267</name>
        <name evidence="3" type="ORF">HUG17_4475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I953"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7641431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9527236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="169" mass="19449" checksum="4CF9CB2DF8E60226" modified="2023-02-22" version="1">MSDTEESMIGSMEEEALKRKQRLDELRNKRKNSETNQSESNAKNSIQLPKPKFRNYNPSDESLKENSLPKARPENVKDQLTDELEIAKSNDALVDDIDLTKLAPKKIDWDLKRNIAKKLDKLERKTQIAIAELIRIRLKSSKIEDLDQATEDLESANRNIDLADDDIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9Q2</accession>
    <name>A0A922I9Q2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9Q2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="158" mass="18515" checksum="BE32B848CB496E92" modified="2023-02-22" version="1">MGAVPGMNRQRSKTKKSSKNKSKRQRRRQQRQQQSSSVKIMEKIKVKNKNILKGKIKDDDNSSINIIDSNDLSRRMLEILAKRKSKRLKRGDYSGVKLNEIQQKEEFENQNVSINKNVDNENLNNGRMNGKEYIVVVCDNDDNQQQQQQQRQHLQGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA93</accession>
    <name>A0A922IA93_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA93"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="524" mass="60763" checksum="14F0E00DC613E965" modified="2023-02-22" version="1" fragment="single">MFFESDFRPSAPFITVVATFIIFIVLICLVRLFISPYILMTVYDDCNFLNYQHQYVLRLLFAGISSTYEPETTTVTVRIDHSIRRCRDIPFMPEIMDRATLYKGLHCAKIFIRTCERYQDIKCVTLYHNGRGSILVDSVELQDVDQANSIIATFEPFPFGREKLTEIEDDIRPTSNVTCLETYYFIYASLNIIYALNAFTFMSKCSQPGAECRLQMIFVLGLISCGLSCAAFILLILPFRYVIKVYYHNNMGRGFCKLARFVYLLIVLLIGFMTAGFACELSTKNQFHRVNEANHLFRADTFWLVTTGFSVFLYFCVVCMAIPLAICINYIQLPSDQHWRQQLQDTWARAQRHGHGHKQRRRPVANNRNRWHSYRSDEAQSLVTSRNQPDNKGYEDDRRITTTTDTSTDMDSYYNMLIKRKNEIKSISTFVKPGLLAGGIRRHFKRQQRQTPVGATIAYGHDNLTLGKYHKPTNDKPRPIENKKQPARNDSLHQFSSAGEDYYQLMLKHQKVRSVSQYKALANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAG2</accession>
    <name>A0A922IAG2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAG2"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="148"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="371" mass="42036" checksum="E69348D2D0F59D2A" modified="2023-02-22" version="1">MISTKYSLKMTSIKISISLATILVAVVSAKKPNPLPSIPANSSVLNRVRPIPSVSTTTIVLPTRLPTSSTPTVPVSSPSTSASPSLSVPEIQSIPAQSAPAVSIQAPPQPSGDQVPQVVITAEQATLLDRFMGPYKHRRNIRILYDADFQYRCLDAMNRKRLWHENTPPLVLGDNFTQYTIDRAWSILSDIAEGKREIVKGPYAFGESFFWYYDPKRYRAVEEAINTWYDEERHYDYSEPRFSARTGGFTQLVWRGSREATCVKIEFETPQNYKTLIVANFWPPGNVKGEFSANVMPLRSTRPDMVEPPSHKNKRPWPRPPYRPTTEPPSYPTHPLFNHGVYEVPQSKIKNQHVEEDPHKIVEETLKTINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAK8</accession>
    <name>A0A922IAK8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAK8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="58" mass="7084" checksum="ED8E71922D5BB1F9" modified="2023-02-22" version="1" fragment="single">MLLLNVIYMDNAAKYWHQQQQYIDLFDHRQIDCNFKEYSVVFFATISPSAIFENLFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB53</accession>
    <name>A0A922IB53_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Paired amphipathic helix protein Sin3b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Histone deacetylase complex subunit Sin3b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcriptional corepressor Sin3b</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SIN3A</name>
        <name evidence="17" type="ORF">DERF_000247</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the SIN3B complex, which includes SIN3B, HDAC2 or HDAC1, PHF12 and MORF4L1. Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SUDS3 enhances the interaction with HDAC1 to form a complex. Interacts with CRY1, HCFC1, MAD3, MAD4, MAEL, REST, RNF220 and SETDB1. Interacts with C6orf89. Interacts with MYT1L.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000005">
        <property type="entry name" value="SIN3 transcription regulator family member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="16">
        <location>
            <begin position="987"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="258"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="495"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="730"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1195"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1533"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1608"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="305"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1201"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1217"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1534"/>
            <end position="1551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1553"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1611"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1659"/>
            <end position="1673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9526139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1910" mass="214494" checksum="8D708BC8F09064C4" modified="2023-02-22" version="1">MNTANVTANSIVNVGAVGATQPPLTANITTIKTHQPTALLHQPNTISLPATIITAATNETTSRLNNTSTSNQTPPTQQQPTSATVTSNHGIQIQTVNAVANTTSIMHPVTITGVTTAGPSSVVCTATILPTGATVSTAGGHSQVTAIPVGPNTVLKAQPTMTTIPIGQRFQATNVAIGTSAGPPPPTGTPINALFIHQDPVTAQKNLSNSSAHTNMVTTSNHPHQQSHATIQQNSTTTATVINTSNVSVTGVPGTTTVTLQPISSHSNSQQHHTTAPIFVQTGPNTNPNSNTATPNSAIFHQIGQHHPNSSSQPTPSSQPQQPTNLSTINLSTSSVQPSSQPSATTPSQSAPQQFQRLKVEDALSYLDQVKFKFNDRPQVYNDFLDIMKEFKSQSIDTPGVIQRVSNLFKGHPELIVGFNTFLPPGYKIEIHSNDQVNVSMPNSTNVVLMSNTPITPSTHQQQSISAATTPVGHAIVASSQNIHQIPSNLVRSPSIASSNQSLHHGGPPSHHPLNTFVNSVPPRNETTNLASLSSTTALPHSTSQNASSFNQNRIESSTTSHNHRSSSGHIDSNSRGQTTNIHHHLANAGQQNAGSVPGSGPVEFNHAINYVNKIKNRFLDQPEIYKQFLDILQSYQKEQDNSGQKILTESEVFSKVSKLFENQPDLLQEFSQFLPDAHNSSGSSTVGAVGPHTLLQNQATNATSHHHQHHHMNNNNNNIIIIQNSANPTTSSMNQYGQHHQANLEHSSSNYTHQPSSQTIPISHEQHNSMTSKKTISVINTNSVLPNRTSIANTNTPNAFPNTFHRTPKRSISNNQIEQSNSTHVTFKRSKLAPFRESATSEAGKYMGDLVEYAFFDKLRLAMNSPYNYETFLRCLILFNNEIVNRSELAQLVHPLFSQCPDLYKRFKEMLNIKEGSLAMNSVNLQNHNLYYNLYNNPYMNNLSNSSYHTNSYANSSIGHLEGLSNRIASFRDRRDNEFAEVDFASCKRYGVSYRTIPKSSAKQECSGRTPLCREVLNDTLASFPSWSEDSTFVSSRKTQYEEYVYRCEDERYELDLIIETNLSTIRVLESVQRKMEIMSPEEKSNFKLDDTLGGSSHVIHINSIRRIYGENSVNVIEGIKNSPANVIPLVLRRLISKDEEWRDAQKQFNRNWREQNEKYYLKSLDHQGISFKQNDIKFLRSKSLLTEIENIAEERSDQNEQQSSQNEQWSSQHSTSNGNMNDTCQSDDRKSDTLQMPHMIFVYPDKSMIDVACNLIIHHVKRQTSIHKEDKRKIKQLMRHFIPDLFATPRGELSDDEIEDEPKNEKTKTLLENIKLEKDSDLSKNEKVEIKPQPMFNSNPDEEYSLFFVNNFWYLFFRLHNILCERLSKMHKRAQQIAAEEVKENQTRNSSPSILLRLRNNLNVKVENYFATLVDMIKQVLDGNLDSTQYEDNLREMFSIHAYIAFTLDKVVQNIVRQFQHIVVDDCSQQCTELYLEACKSGSAGGLCITAHQRAEAEYLYQKNIEQIIPDDNRYKIVIYKGEGKITIDLLESNDDEDEDSTNDGDEDSNIPQSSRTLRSTTKNMSAKEREKCLMNEQQKVNELVVEKFRTNPPFLKKYVRKHKGSFDPITQMNSDSNEVEQQSPKPNEESNSTSNSSDKETNTNRPNSTNDEKMANKNTISDSNQSTITTRGDDENQLSTTNTSTNNDKDKTKNTTEANNECEFDIHRFKSLIFVQNETVLYRKNIDKPRMSHKKISQSKFKRFNKWYSDWVDANCTESNKYKYEKWLLEQDTTDFRLNQSDNEDNDKTNQKQPLIEKKSNIDIKLEKEVSNNDVNKQAKNDENLKTEISVKISEQTTTSSSIEQQQQASITTTMTTINVIDSTKKSSNEDSTNGTRSESNKVIQKVKFDSESVIPYRIYYKYLFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB78</accession>
    <name>A0A922IB78_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calcium/calmodulin-dependent protein kinase type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CAMK1_1</name>
        <name evidence="10" type="ORF">DERF_000933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB78"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14083">
        <property type="entry name" value="STKc_CaMKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000026">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="79"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="396"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9526875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="467" mass="52882" checksum="E5C7DF286CA3F4A6" modified="2023-02-22" version="1">MPLFGKVKDQQQQSSSSSTTTTMNKVNENENTKTNSNSNNKNNNPNSNPNGQQTTATTTTTTTTMTGKMNPMPRVEDKYELKDLLGTGAFSQVYLAQNHHDPCQMVAIKCIDKKALKGKEDSLDNEIKVLRKLKHKNIVQLVETFEDRNKVYLVMELVTGGELFDRIVEKGSYTEKDASLLIKQILEAVDYMHSQGVVHRDLKPENLLYYSQSEDSKIMISDFGLSKMEESGVMATACGTPGYVAPEVLAQKPYGKSVDVWSIGVIAYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDDISDSAKDFIRHLICVDVSKRFTCKDALLHPWISGNTASEINIHSSVSEQLKKNFAKTKWKQAYNATAVIRQMRKLAMCNNSSTTITMTTTNHHNDITSNITHHDHHHHHQHHSHNPHPHNHPNQHSHHSHHPHHHHNEDEELFSNTGDIATVNEEQEKQQLDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICD2</accession>
    <name>A0A922ICD2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICD2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="305" mass="32126" checksum="981A95C65464D639" modified="2023-02-22" version="1">MASSFAYGINVELNIAGMCKVFDCEYEDDDVGGGGGGGGGDWEFDGGSNVCDRICICNAESLPKTFPQNLHRCLLAGSSLPSLPLRKLSSSLLSVVERPFRRNEPPDIVFCNACSVCFCNNSNVFGSLNDAGSDESTLGGLIIGGNGASGFVSFRSSNDEMSLRVGFEFVIDSLSRSLLAACCCCCSLVDDESFRSDCDDGIGPPVNNGVNDSKKAFISGIEVAKDDGAVVVVDGIGDVIINSLAIGQCPDNTFNGLVAHSVAAHPIMIDADVEVRDVYDEEVIVDADLVEKFIKISLAKSTKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICN4</accession>
    <name>A0A922ICN4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICN4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="87" mass="9719" checksum="2ACDA33EB6ED1B04" modified="2023-02-22" version="1">MVRMMAEDVDGYGSGPILNPFIFAPHPKKNQYCCSNHRVVIFGYRHSPILGLNISIPCGCNDRSDLHHISTKKKQLATIIFSCNSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICS0</accession>
    <name>A0A922ICS0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Inosine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_002615</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:27738"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27750"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:13233"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICS0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="16">
        <location>
            <begin position="70"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9528695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="336" mass="37145" checksum="3046977C540ABFB5" modified="2023-02-22" version="1">MDHLLLNIKSYLAKSKSPIKSKNHHHQHHNHNHQQQNSPDLSLHENRFITHEEIDETVKYLKSKVSIEPTIGIICGSGLGGLADLITEPVSVEYKDIPHFPVSTVHGHAGTLVFGHLGKASVVCMKGRIHAYEGYSLARCTFPIRVMKGLGVETLIATNAAGGLNEHFNVTDIMMIKDHIFFPGFSGNNPLRGPNDDRFGIRFPAMNTCYDQELMRLAEEAVDKLKINKHFQKGVYAMVGGPNFETVAEAKLLRMVGSDAVGMSTVHETMVAHHSGMRVIAFSLITNKIVMGYDSDDKANHEEVLAAAKERSKDFENLIQEIVASIPNGHIVANDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ID52</accession>
    <name>A0A922ID52_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4460 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_003226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ID52"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028031">
        <property type="entry name" value="DUF4460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027989">
        <property type="entry name" value="DUF4461"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027986">
        <property type="entry name" value="TCAIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596:SF1">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14687">
        <property type="entry name" value="DUF4460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14688">
        <property type="entry name" value="DUF4461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4460" evidence="2">
        <location>
            <begin position="45"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4461" evidence="3">
        <location>
            <begin position="214"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9529336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="91564" checksum="36A81DEDD5438E7C" modified="2023-02-22" version="1">MRSVLNLLWTIHSRHFNHFYNHHHHHHHHFIYENICKRCIHSALRMTSQEVATALRPFIFTVHPDRFWNHPKEKNTNEISLKRLNEFLGDKNDGKTTSIGEETITFYILNKEGSRSNEKSALNKFEKVDIKLNSKENVSTTVHRILSQCSLPTDYLKKISQEPIKRNNNPSRNNNSYNDEWPTFYRRRGNEYFYSKDIFDDLEAELFRSNMEINLSKWLKENHSLAMKKLEASQPIRIELTRLKQELIDELKLINLEWNCDWTASHIRGALKNLSILSKQYPEDFKKLHSKTVVFSRHNCVSFKGQVILSIEDVRNNWLYLIRSIKSYDFYVQNIPHAEKKLSGLLQDITIKQPEYNLWNAKKYFNQLERFIRSVQSYNYDRNFPSNWPASLAEHQLIVESDSGPLMLSPTGDFIVPASCPISLLIKFIMENLHKANRLIDKEEFNLEHERVIRKECIETFQMKHLDKDVNITPEQMIDFCRRILNDKQEFEDYLKNAHIQKKIKEFETEINNILVQFKKDPAVQNGIVHFNDLIELSSIRRLFRSKNRSVFTLLKYLFYLSSVWILLNNGHNIMRFYRSYSQSKCLIPLPDILQNAFVPANECNFCLNLTRIDRVHSITPEIFSKRTEFHSLDEVFRMDPLRSNFTKGTKPWYIGWSNCDYRIANEIRSHYMKPYFLPVDSESIRTDWIFMGTPDNGAHMHIDHVGRPSWQAQIKGTKRWFLEPPLECYPECLDLTIDVKQGDIIVLDTNIWYHKTLIIGDEISLTIGAEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDM9</accession>
    <name>A0A922IDM9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_002836</name>
        <name evidence="13" type="ORF">HUG17_4925</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDM9"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000021">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002634">
        <property type="entry name" value="PRK02304.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="51"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7641880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9528928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="190" mass="21522" checksum="69BD5151670AAE98" modified="2023-02-22" version="1">MNDQKHNQPNDGDDIQKRLDRIKMNVKSFPDFPKSGIIFRDIFPLFHDPSLIDDVLYILKHHIKNNIKNYDTIIGLESRGFLIGPLLAYELRVPFVPIRKAGKLPGKVESIAYELEYGSDKFEIQIDSVKPNSNCIIVDDLLATGGSARSAVELIRKCGSNIVNVIVLIELIDLKGRLQYPEPTFSLVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDV1</accession>
    <name>A0A922IDV1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_003513</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts on the folding of rhodopsin RH1 and RH2 (but not RH3) and is required for visual transduction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDV1"/>
    <dbReference type="OrthoDB" id="10064525at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000019">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF559">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038170570" description="Peptidyl-prolyl cis-trans isomerase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="32"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9529639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="201" mass="22167" checksum="35EDBEDBD94F9B89" modified="2023-02-22" version="1">MMYRPIILCVLFLAFSSIYTKAYEVNVTDKVTFTIAIGNETAGKIVLGLFGELAPKTVENFVTLASEDGYQSKSYNGSLFHRIIANFMIQGGDITSEDGSGSISIYGEYFDDENFVLNHGQPGLISMANAGKNTNGCQFFITLVPTPWLDGHHTVFGKVLDGMDFIFRIGSLPTDSNDRPVQDIRIIDTKTEKVNVQTTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE44</accession>
    <name>A0A922IE44_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE44"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037392124" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10584" checksum="B22BB958922E542A" modified="2023-02-22" version="1">MNHKFTSFSRLLHLFVLAIKTFFFHFCSQNFSAGTALNQNPHSHRFGSFKCSHIYLIAEESSSHLQPTIRVPENFLVHELVLEDRMDLCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE92</accession>
    <name>A0A922IE92_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE92"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="118" mass="13757" checksum="139F41C2969D91DE" modified="2023-02-22" version="1" fragment="single">NKQKKTFAVPKENPVCVKIDRSKKEEKYVVFSIMPNKNGWLIYNKKIGCFEIQIINTTCGGKHLIDKIVSNGKKQKQCFPFIPFETTNSVKKETKNSVFVICRQQQQQQKTLFLFLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF13</accession>
    <name>A0A922IF13_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Y+L amino acid transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SLC7A6_3</name>
        <name evidence="6" type="ORF">DERF_003440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF13"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000095">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000056">
        <property type="entry name" value="Y+L amino acid transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF240">
        <property type="entry name" value="LD25378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
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            <begin position="341"/>
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        </location>
    </feature>
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            <begin position="376"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9529562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="438" mass="47747" checksum="96B4FDB4B4AAF672" modified="2023-02-22" version="1">MSESGNGKSPQQQVALKKQLGLINGVAIIVGIIVGSGIFVSPRGVLQEAGSVGFSLVVWVLCGLLSTIGAVCYAELGTSIPKSGGDYAYIREAFGPLPSFLFLWVALLIINPCSNAIAAMTFANYILQSIYPVCAPPPNAVRLIAASVIILLTFVNCYNVKWATRVQNSFTFAKVLALIIIIVCGIIQLVKGNDRNLAYPASFEGTTTSPELKSPFKNLPRAIYISLPLVTIIYLLANISYFTVLTPHELLTSNAVAVTFGDRVLGSFSWIMPFSVAMSTFGGLNGGIFASSRLFFVGARYGHLPKSLAMINLKYYTPIPSLIFLGFLSLLYLTTTQVYTLINYTAFIESLAVAASVGALLWLRWKRPHMERPIKVNILLPILFFITCLFLVVLPFYVSPYETGIGALITLSGIPIYLVTIAWKNKPKMYQRLVGKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF45</accession>
    <name>A0A922IF45_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF45"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
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        <location>
            <begin position="127"/>
            <end position="203"/>
        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="443"/>
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        </location>
    </feature>
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            <begin position="179"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="466"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="627" mass="71010" checksum="42C229FC33DCDF61" modified="2023-02-22" version="1">MMKLSSLSLFINSRTMPFILLFYIQIIFQLFFIQTMIIIPTVHARMGLMNKLRILALLSLVKKIDVVPFPFPIPIPIHIDGKEEIVFMNSMPSNGHLSQPSYSTSSSSSSSSSGYGYSASELSPVSISPNNGNHLRYGDRISTNNRPALGNHPGQTTTYRMRKEFRHRQPPQWYREINKNQNKQTTDAKSLDQSSSTTIVQDPNADNVNLKDIKIIFIPIKNLQQQMNQQQNGNPNTETTIIESDMKQLTDEIKEQLKSNNNQPKTIIDKPNTDNRTTMDPSTTVTTMPPTTSTVSVNKTETEAPIITDKQIVSSPKSIDAEEIMIDDHDDDYERRQLPPSSSSSSKNVVENQYTVDAPSIDQTSKPETFTKFVRMNQPTTPTIYQLPPPPPTTETPTYQASSAPFPIPSLESEWLKQNSYVPRARYYKAPELKILHHLKSNQDEQHHQYLPPSSHSSSLPQPPSITNQWSSSGPQTDPSHPIQFLYSVSHANNVPVPSFPTISPSSSSSSSASLNYNSLTLQRPHIQPLQIQSSMARFHRYPIVDNFGLEAFHRHRHQQQQQQQYRRRPLMMSQRHPLIIKNNAIDDIQQWPITSTWTQRMQPSSSSSSSSSSSSLLSRFSKRLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGN0</accession>
    <name>A0A922IGN0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S phase cyclin A-associated protein in the endoplasmic reticulum</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_003380</name>
        <name evidence="5" type="ORF">HUG17_5335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGN0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032446">
        <property type="entry name" value="SCAPER_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31434:SF2">
        <property type="entry name" value="S PHASE CYCLIN A-ASSOCIATED PROTEIN IN THE ENDOPLASMIC RETICULUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16501">
        <property type="entry name" value="SCAPER_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S phase cyclin A-associated protein in the endoplasmic reticulum N-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="390"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7642290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9529499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1137" mass="132882" checksum="7DC614F20C965305" modified="2023-02-22" version="1">MVKLESINRTRSASLGRTRNFERRSRYWTFLFDHLNRIIDEIYQNCEEDESIDECREVILNLQNHIRDFESLIEWLKLNKDLESTPQRPSSVSWEVRKRLPEKSLFSCYLNDEKTKGFNQNNEELKEKIDAVKNNNDEDTISHSQIDESLLTKSDTFETLLSNYDNGNGLMSSVHSDNQSDMKHVIKKDTVSNTGQNHRYSMPNISSSKLDDDGFQVVRYRQRNKVTELKIIDHNDNSTSKHNANLFVHHNDRMDSGNMIGDNRAPCRVLKLHEKFSSPSRRRPVGDTLKKQEEKQAKAQEAREKLLEKRAEKFKDIFKKVEEIKAQKEEQQMQLRLSMEMRLQRAGKKRQEQINKIVRKAHDEDEKVSEILFINSLEADTKKHEIFSKEKVYESRLQDLQEERQRKLEEKASKEKAFEERRKAIEAEKQARIEKLKEQRKLKVMKIQRQFQEKEKERLELAFQKELDRKSKISALNALHAAEKEELQKKILAKQEESKRRHEENMEQIRQKALELSVKKSSSTSDEALVCVPYDTVKMCALCKIIIKSEVYLFGHLRGKRHNDAIIEQNEGKIPSPEELENFNLKFIIDAQTLGDGNDDFLKSFQDCDSEKLKQAKKKSKKLKQKLANRAMDFEKTFDLEKDVRISEVENISKDSKQKLAKIIKDLGALNSNDRISGQWPIDMIRSFERFLFELDKLFKKDSSHILYFYRSGGLLLFTKILSRILNSSAERPTSLTDNANNKLIALYRRLCQSDFRICRYFFRSQNIITVQEIFYHRINLCVNSNNNNSNVMSFPYDSVVGSLCELFSTSFDQIFAYYSCNYDNDDETTRFIRTHLKEIINYLVLIGVVDKLSMILTSFRGSINELPQQSLFIKQIITFSSSLAKLLNLSSSDDFHAIAYGVNLQHDGTQFMLTLKVTQLCGTVSLLYGFLLHSGAPVRDENVPPIVPDHTLNVTLEIIRFFNYLILLDINLIQSILGSEGLSLQIRHICSYLIWYCSHHLSNSDLLNEVILLIGNFVVLNNDNQTLLQSGQRPTVVQQLCSLPFDYFSDNRLKQILFPTLIVCCYNNNDNLNILKQEMSTTMLSKFIDQEIVNNQLDQLDSDRRENNIISKKWSLTIRFPKHKWIEAKSYFERFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KUJ2</accession>
    <name>A0A922KUJ2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein KRI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">KRI1</name>
        <name evidence="6" type="ORF">DERF_013081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KUJ2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="5">
        <location>
            <begin position="497"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="576"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="350"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="642"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9497071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="734" mass="86134" checksum="A9DE2D14EA72EF40" modified="2023-02-22" version="1">MTSFQKEKLFDSDHDDDENNKLFSNDHPSPSSSTSTLVINTENSYAQKYDDWRRKEELQKLKDKYGDNLDIMSEIDDDDSGAGSNSSNESTSDDDDDDSSESLSEDPFDDDFFAVYSALKNKESKIYDKNFKFFTKEDDKEDKESKTSPKQEEKKLTLQKYHEKLIEEKKGITEEDESMMMMNNESNDEQQQPEGYYEELYNIRKDIKNMFKEKSDQNDDDDGDDLFSIKNSDKTLKKKETKPKSMPEFWADDQKLDEDEKFLKQYVLNGGYVSVTLDSKNRLDRYKNVDSHFKVVDQDTSPTEQPEKFSVAENIRKTLEVPKFHYEEPDATIIKRYPRNINSIRDTTVVNDKKSKRAEARERKKMEKEQELKRLRKMKREEIEKKVETLKSVSGNDRLDLKDIDLNVIIDDENDFDADKYDEKMKLLFGDDYYNNSNAESDSTKPVFNYVPEIDDELDEEMNAEINNNGNRKKRKKNKREIKQHKDIMADDDIGLYDDIVGGDLATRFRYRMVEPNDFGLTDEEILLADDKELNRWCSLKKMTQYRSKEHEQYDRKVYQQKSQNLELKRKILKSIYGDNPNNDDNDNESNIMSKSKSKRTLYPIANQSSDDNDEKVKIDDHDPSANGSDTKIDTVEIKTTTNKRKRKRRNHNKTKHPESLSSDKVIEQQQQQQKQSSNGGIEQQLVKKSRKRRRSNKKQNDSNGTTNEIAGVSVQRLKAYGLSNREMKRMRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KUT7</accession>
    <name>A0A922KUT7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoside diphosphate-linked moiety X motif 19, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NUDT19_3</name>
        <name evidence="8" type="ORF">DERF_013225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KUT7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9497221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="234" mass="27257" checksum="7C4D8C65ED1B9BB5" modified="2023-02-22" version="1">MDLGLRISAIRETFEEAVLTSKSLDLDLNEWQKKVRSDAGQFIKLCDTLHMVPNVWALYEWSNWLTPISVGHRRFDTIIYVCCFEQKPPVFVDNAEVTTPIWCIHRILEEHRLEQAFLAPPQVYELSRLLRFPMMDQLYRFMRSRQTLGCQRWLPVFFTYNDGALSLLPGDEQYPVVPALVSNGKQVPEIDGSVHDANREAKSQNRMELMGIKCRTICTIDQAVDMYHQLHILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KV61</accession>
    <name>A0A922KV61_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KV61"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9843" checksum="726A34C3540F0D34" modified="2023-02-22" version="1">MLIPYKDWDNSHLCSPKQQQQQRQRIEKKPQLNYYVEMKITKKKLNSGFRTCICECKLKLMKFETMKNKNDNSPTVTQTTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KXR5</accession>
    <name>A0A922KXR5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KXR5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="101" mass="11769" checksum="B705D77622BBA354" modified="2023-02-22" version="1">MKIFFVLIHLNIMVILNQKHVLRLFKYLLIVVRIVCSGTNIGKIMLDSRNGKSKLTQPVQNRENNKSKLTRPVQNRENNKSKLTRPVQNSKFKIQKITNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY32</accession>
    <name>A0A922KY32_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005162</name>
        <name evidence="1" type="ORF">DERF_015760</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY32"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9491022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="131" mass="13936" checksum="FB65A7E9A86F5831" modified="2023-02-22" version="1">MTKRALRLRTRVVIIEEEWLPSPSSPTSVVASSASSISVVPLSIVFDVDVSNSLVTWNAVITPPSRMNTNSDLMFGTTIRLGLVDANVVAEADVFNDFGSNIGVCAAFLRLRPRFDGVVGVADGGEDVPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY91</accession>
    <name>A0A922KY91_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY91"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="81" mass="9186" checksum="160A95BE716F6CB8" modified="2023-02-22" version="1">MESIMPKTTTTTTVVVAVPLLDMVKPQPPPPLSSIKVNHQTSKMNTGKPKNKMTKRKLLVVQDFESIYEWREEARKTCLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZ52</accession>
    <name>A0A922KZ52_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZ52"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="404"/>
            <end position="424"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="628"/>
            <end position="648"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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        <location>
            <begin position="803"/>
            <end position="830"/>
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            <begin position="1210"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <name>A0A922L028_DERFA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">DERF_013068</name>
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    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
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            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAH9497057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="9060" checksum="178EA9D86234BE97" modified="2023-02-22" version="1">MLLSSSIIDRYHYQPKKKCSMNILYNREYILHNSTFKWDPNKSDYHHHQIRMYMNTDYLNDDMNLKCFTEDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1T7</accession>
    <name>A0A922L1T7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
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            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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            <taxon>Dermatophagoides</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494322.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="115" mass="12946" checksum="AA7B2CE9DE404DAA" modified="2023-02-22" version="1">MENNNIDENNNNDNNGDSMKETINSSSSEPSPNTIQSLMMYGNNGGESLFVSQPSPSSSSLTDSLMAQFEENSRLTNLKRMGYVSSIAHTNHYVTINNDDDENMDYGRRRYKRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L250</accession>
    <name>A0A922L250_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010524</name>
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    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
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            <taxon>Arachnida</taxon>
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            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L250"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9512124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="79" mass="9220" checksum="53CE0C3EF4D287E7" modified="2023-02-22" version="1">MADWLTDASMSSRMAPSPIPMTDDNRRQLESWCRTLNQKLMENPIELISNYALMALLREKYDPGRVIDALLEDLQWLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2C2</accession>
    <name>A0A922L2C2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger, AN1-type domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZFAND2B</name>
        <name evidence="9" type="ORF">DERF_010220</name>
        <name evidence="8" type="ORF">HUG17_0223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2C2"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7644685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9511792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="268" mass="30485" checksum="363C9B59B3B05728" modified="2023-02-22" version="1">MEFPDLGKHCALKECNRLDFLPIKCSSCEKIYCSEHYMYQAHHCESNRIQDHQVPICPMCNCPVPLKFGESLDEKVGEHIDRNCDGKSNSKTKVYKNRCSVDGCKQKELMELECDKCGLNHCLRHRHPADHDCRGRNNKTKSIHPLVAKYDKSNKQNNSSITVPIKSHTIPQSLNSFTQKSLSTIDQFKTNVVRTFQRNTVGSNSMIPASHTINSNINHLQGDLTEEEALNIAIAESLSVNTQSQQPQQQQQQSVNNRTNNQENCQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3K9</accession>
    <name>A0A922L3K9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid synthase</fullName>
            <ecNumber evidence="5">1.1.1.100</ecNumber>
            <ecNumber evidence="2">1.3.1.39</ecNumber>
            <ecNumber evidence="6">2.3.1.41</ecNumber>
            <ecNumber evidence="4">2.3.1.85</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="68" type="ORF">DERF_012586</name>
    </gene>
    <organism evidence="68 69">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="68" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="68">Derf</strain>
            <tissue evidence="68">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="68" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="68">Derf</strain>
            <tissue evidence="68">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="32">Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>(2E)-butenoyl-[ACP] + NADPH + H(+) = butanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:41813"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="62">
            <text>(2E)-decenoyl-[ACP] + NADPH + H(+) = decanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41864"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="62">
            <dbReference type="Rhea" id="RHEA:41865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>(2E)-dodecenoyl-[ACP] + NADPH + H(+) = dodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="46">
            <dbReference type="Rhea" id="RHEA:41881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>(2E)-hexadecenoyl-[ACP] + NADPH + H(+) = hexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41912"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="41">
            <dbReference type="Rhea" id="RHEA:41913"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>(2E)-hexenoyl-[ACP] + NADPH + H(+) = hexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41832"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:41833"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="55">
            <text>(2E)-octadecenoyl-[ACP] + NADPH + H(+) = octadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41928"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="Rhea" id="RHEA-COMP:9656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
            <dbReference type="ChEBI" id="CHEBI:78495"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="55">
            <dbReference type="Rhea" id="RHEA:41929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="48">
            <text>(2E)-octenoyl-[ACP] + NADPH + H(+) = octanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41848"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="48">
            <dbReference type="Rhea" id="RHEA:41849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="57">
            <text>(2E)-tetradecenoyl-[ACP] + NADPH + H(+) = tetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41896"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="57">
            <dbReference type="Rhea" id="RHEA:41897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(3R)-hydroxybutanoyl-[ACP] = (2E)-butenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41808"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="Rhea" id="RHEA-COMP:9627"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
            <dbReference type="ChEBI" id="CHEBI:78453"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:41809"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41860"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="Rhea" id="RHEA-COMP:9639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
            <dbReference type="ChEBI" id="CHEBI:78467"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:41861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(3R)-hydroxydodecanoyl-[ACP] = (2E)-dodecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41876"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="Rhea" id="RHEA-COMP:9643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
            <dbReference type="ChEBI" id="CHEBI:78472"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:41877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41908"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="Rhea" id="RHEA-COMP:9651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
            <dbReference type="ChEBI" id="CHEBI:78481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41909"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(3R)-hydroxyhexanoyl-[ACP] = (2E)-hexenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41828"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="Rhea" id="RHEA-COMP:9631"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
            <dbReference type="ChEBI" id="CHEBI:78458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41829"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41924"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="Rhea" id="RHEA-COMP:9655"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
            <dbReference type="ChEBI" id="CHEBI:78489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:41925"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(3R)-hydroxyoctanoyl-[ACP] = (2E)-octenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41844"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="Rhea" id="RHEA-COMP:9635"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
            <dbReference type="ChEBI" id="CHEBI:78462"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:41892"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="Rhea" id="RHEA-COMP:9647"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
            <dbReference type="ChEBI" id="CHEBI:78475"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41893"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>3-oxobutanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxybutanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41804"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9626"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="ChEBI" id="CHEBI:78451"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="43">
            <dbReference type="Rhea" id="RHEA:41805"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>3-oxodecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41856"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
            <dbReference type="ChEBI" id="CHEBI:78466"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:41857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="58">
            <text>3-oxododecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxydodecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41872"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9642"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
            <dbReference type="ChEBI" id="CHEBI:78470"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="58">
            <dbReference type="Rhea" id="RHEA:41873"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="59">
            <text>3-oxohexadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9650"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
            <dbReference type="ChEBI" id="CHEBI:78480"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="59">
            <dbReference type="Rhea" id="RHEA:41905"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="50">
            <text>3-oxohexanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41824"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9630"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
            <dbReference type="ChEBI" id="CHEBI:78457"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="50">
            <dbReference type="Rhea" id="RHEA:41825"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>3-oxooctadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41920"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9654"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
            <dbReference type="ChEBI" id="CHEBI:78488"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:41921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="60">
            <text>3-oxooctanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41840"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
            <dbReference type="ChEBI" id="CHEBI:78461"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="60">
            <dbReference type="Rhea" id="RHEA:41841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="54">
            <text>3-oxotetradecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:41888"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9646"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
            <dbReference type="ChEBI" id="CHEBI:78474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="54">
            <dbReference type="Rhea" id="RHEA:41889"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="36">
            <dbReference type="Rhea" id="RHEA:17399"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:13098"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="51">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.39"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="51">
            <dbReference type="Rhea" id="RHEA:22566"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="49">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="49">
            <dbReference type="Rhea" id="RHEA:22837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.85"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>acetyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxobutanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41800"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:41801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="61">
            <text>butanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41820"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9628"/>
            <dbReference type="Rhea" id="RHEA-COMP:9629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78454"/>
            <dbReference type="ChEBI" id="CHEBI:78456"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="61">
            <dbReference type="Rhea" id="RHEA:41821"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="56">
            <text>decanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxododecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41868"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9641"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78468"/>
            <dbReference type="ChEBI" id="CHEBI:78469"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="56">
            <dbReference type="Rhea" id="RHEA:41869"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>dodecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxotetradecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41884"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9645"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:65264"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78473"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:41885"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="53">
            <text>hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41932"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="53">
            <dbReference type="Rhea" id="RHEA:41933"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>hexadecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9653"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78483"/>
            <dbReference type="ChEBI" id="CHEBI:78487"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:41917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>hexanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9633"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78459"/>
            <dbReference type="ChEBI" id="CHEBI:78460"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:41837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="52">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="52">
            <dbReference type="Rhea" id="RHEA:41789"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="63">
            <text>octanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxodecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41852"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78464"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="63">
            <dbReference type="Rhea" id="RHEA:41853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30123"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:30124"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>tetradecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexadecanoyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:41900"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9648"/>
            <dbReference type="Rhea" id="RHEA-COMP:9649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78477"/>
            <dbReference type="ChEBI" id="CHEBI:78478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:41901"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="64">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="68">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="5"/>
    <dbReference type="EC" id="1.3.1.39" evidence="2"/>
    <dbReference type="EC" id="2.3.1.41" evidence="6"/>
    <dbReference type="EC" id="2.3.1.85" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08954">
        <property type="entry name" value="KR_1_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000013">
        <property type="entry name" value="Fatty acid synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049391">
        <property type="entry name" value="FAS_pseudo-KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF7">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21149">
        <property type="entry name" value="FAS_pseudo-KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="21" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="22" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="69" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="66">
        <location>
            <begin position="11"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="67">
        <location>
            <begin position="865"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="65">
        <location>
            <begin position="2125"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="64">
        <location>
            <begin position="865"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="64">
        <location>
            <begin position="999"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00023399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00023401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00023402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00023442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00044883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00047300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00047394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00047400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00047440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00047451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00047500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00047578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00047810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00047897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00047953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="ARBA" id="ARBA00047961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="ARBA" id="ARBA00048051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="ARBA" id="ARBA00048281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="ARBA" id="ARBA00048289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="48">
        <source>
            <dbReference type="ARBA" id="ARBA00048420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="49">
        <source>
            <dbReference type="ARBA" id="ARBA00048506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="50">
        <source>
            <dbReference type="ARBA" id="ARBA00048571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="51">
        <source>
            <dbReference type="ARBA" id="ARBA00048650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="52">
        <source>
            <dbReference type="ARBA" id="ARBA00048691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="53">
        <source>
            <dbReference type="ARBA" id="ARBA00048704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="54">
        <source>
            <dbReference type="ARBA" id="ARBA00048935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="55">
        <source>
            <dbReference type="ARBA" id="ARBA00049019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="56">
        <source>
            <dbReference type="ARBA" id="ARBA00049109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="57">
        <source>
            <dbReference type="ARBA" id="ARBA00049171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="58">
        <source>
            <dbReference type="ARBA" id="ARBA00049263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="59">
        <source>
            <dbReference type="ARBA" id="ARBA00049414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="60">
        <source>
            <dbReference type="ARBA" id="ARBA00049422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="61">
        <source>
            <dbReference type="ARBA" id="ARBA00049449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="62">
        <source>
            <dbReference type="ARBA" id="ARBA00049521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="63">
        <source>
            <dbReference type="ARBA" id="ARBA00049533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="64">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="65">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="66">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="67">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="68">
        <source>
            <dbReference type="EMBL" id="KAH9501768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="69">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2527" mass="282527" checksum="9B3AA2B378A5363B" modified="2023-02-22" version="1">MPHKILQNFIDDDIVISGISGRFPESENIDELKENLYNNVDMVTEDDRRWPVGFYGLPGRNGKLKDLSKLDAQFFGIHGKQARNMDPQARILLELTYEAIVDAGINPQTLRGTRTGVFIGSSTSEVEEALVEDVERANGYALTGCSRSMFSNRISFTFDFQGPSYTMDTACSSSFMALHQAISALKTNDCDQAIVGGTNLCIRPVTSVQFNRLNMLSSDGKCQHLDNSANGYVRSESCSVIFLQRKTAAKRVYATVLHVKTNTDGNKPEGVTYPSWRSQMTIMRETVEEAGIDPAEVRYVEAHGTGTPVGDPVETKAIAQVFCPDHRKEPLLIGSVKSNLGHAEPASGLNSLAKVLLTFQNKMIPANLHFKTPNTNIPELMDGRIKPVIENTPFKDGIVAVNSFGFGGVNVHVLLKPHVKELDPIKSSIVTEIPRLICVSGRNEESVNHIFDFIERNPDKVNPEFLALLNDVAMTEENSGMNSRGFMIADKHPDGETTLPREIGRVQEKRPVWFVYSGMGSQWTSMAQGLMTVDIFRQSIEKSAQILKKLDIDLMNILLSKDEKVLDTTVAPFVAIAAVQIALTDLLRALRIEPDGIVGHSVGELGCAYADGAFTHEQMILSAYWRGRCVEMANLPKGLMAAVGLTWEEAKSRCPSGVVPACHNSQDSVTISGKYDETKKFVEQLKSENIFAREVKSCNVAFHCFFMEQIAPTLLKKLEPIIPDPKLRSSRWLSSSFPEDRWNDEMAKYSSASYYVNNLTSPVLFHEVVQKIPANAIVIEIAPHSLLQPIIKRTLGSEISYLGLMKRNNNDQQLSLFLNSTGKMYNLGLNPNITVLYPKIEYPVSRNIQSLSPLIKWDHSQSWLVLLYPEYFNPSNKADHSVKIDLNENSEKFYADHCIDGRILFPATGYLYIAWQMLAKFKGQVCEQTPVIFENVSLHRATILHEETPVKFEIHLMESSGEFTICENDMIVVSGKIQLSEGSPVKLQDVLAEKPIGQTIRLTGKEVYKELRLRGYDYGKNFQGIVEADSREGRLQFSNWIVLADNMLQVGILGQNNRGLYLPVRFQSVRCDPKILYEAVEKSDGVLTVINDHRINSIIAPGLEIQGLKVNLAPRRINSQIPMLEKCHFTAYNQMDVFDPQIHSKLNEYNNVLKFVSNQLIDHLKLSSVEKFPVKIEESLLKSYLESSDEYPLLSILRQLLMGQNFNDIINQIDFTSDPLWTAHESFINVPIHVIIENHMTARLNIAEVNPTNRPLISIVKQSVESSGYPINVDYTILTTNPQELSEEIEQVTWNPKERLSIASDSTDLIIYKDSYLQSPFADQSIDYSVMIESMYQSIKDGGFLMAIFRSKPTTAENLLLTLKKLKNLYADHIDQFKLKAEKLGFELISERSDDLTSCVLLWRKIDHPIPANGQAVIHVTTSNYDKWVEELKTKMVEYQKRNVGENIWLIANDNPANGVVGLVKCLRQEPGGDRIRCILDTDIKDHTLPKFSTFDDTQGFYSNILKKDLVMNVYRQNRFGSFRHYELDNVDTKVATEHAYLNVAIRGDLSTMQKSMGNLYTVYYAPLNFRDVMLATGKLPPDALPGDLALQDCILGLEFAGRDQQGARVMGMVPSKGLATSVLIQDQDFVWPIPDEWTMEQASTVPVVYSTAYYALIVRGELEPGEIVLIHSGSGGVGQAAIAISLSMGCTVFTTVGSQEKREYLKQRFPQLTDRNIANSRDTSFEQHILRQTNGYGVDLVLNSLAEEKLEASVRCVAQHGRFLEIGKYDLSQNNPLGMAAFLKNIAFHGILLDALMDRDSPSPLIEAHKKTVSKLVLDGIATGVVRPLKSNLFDMDSTEQAFRFMATGKHIGKVVIKIRQEEKLKAVRPTVQPVMAIARTVLYETKSYIITGGLGGFGLELARWLIERGARNLVLVSRSGVRQQYQRYCIEQFELSGVKVHISTANIVTMDGVNQLFKEASSMAPIGGIFHLAMVLSDGFIENQTGESFEKVCASKVRGTQILDAVSRKVCTELDYFVTFSSISCGRGNAGQTNYGFANSSMERICELRRASGLHGLAVQWGAIGDVGVVSEQMGGNNVVIGGTLPQRMPSCLSVLDRFLQMTEVAVYCSHVRAQRNNEKSSSSSAGSGQDILKTIANILGIKQLENLPPNTSLSELGMDSLMAVEVKQFLERNFEVILSVQELRSLTIKNLMEIGGLNQATKEDSKVKSSTNTTPSKVMALSMPVLKLPTEKFIKLNDNGKGRPIFFLPPIEGNFELLKQLAQKCSNPVFGLNWTAALRDCSSVDQASDYFVRLTTDIVDDCSTINLVGYSFGAIIAFDLALKLQSNQSQVSLTMLDASPINIGSTIHAYRDRVYNVNDDEHSKQTESLIFLLGQLTRIDSKQLRQHLMAMNDKQQQLRKVAEILAENGLIQSSDISDTMVAIETFISKLIMMAEYKPEQKFTGNVMLIRAEETLVKSGELDDDYGCSKTITGKCECHKFPGNHQTFITDNVDRISELIQKKFDLKHFFLIMHEKFYYFKLKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3W5</accession>
    <name>A0A922L3W5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3W5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9510805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="188" mass="20101" checksum="909F0A9631F02BD5" modified="2023-02-22" version="1" fragment="single">LNGSTYDGSMMTTLGGVGHNIAESIQRLREPCLFITAVGQDQPGQMIISSAATAINDNNNRAMADTTTNIRSLKQLPTPSCTVIIDAQGECRMVVGDFRANQCIDKNFVSRFETQLKQTSIVIIDANIPTETMNYVCQLCRQAKIPGLGPVVDNGGCGGVFSGIVSNPLVVPLPIDLCNDQNENGIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3X6</accession>
    <name>A0A922L3X6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">G-protein coupled receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">GPRMGL2_1</name>
        <name evidence="20" type="ORF">DERF_007718</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">Derf</strain>
            <tissue evidence="20">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3X6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15293">
        <property type="entry name" value="7tmC_GPR158-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043458">
        <property type="entry name" value="GPR158/179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054714">
        <property type="entry name" value="GPR158_179_extracellular"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 158-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32546:SF16">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR CG31760-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22572">
        <property type="entry name" value="GPR158_179_EC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="19">
        <location>
            <begin position="264"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KAH9517016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="596" mass="69689" checksum="D958CB75AA89D3F8" modified="2023-02-22" version="1">MNKLESIYSRFHHQQINLLLLHEKQHYIRHSLTNNEQFRRVEKCIDLLARILGDYEPFLDRFQLLNQTIMQTPLIESKISSLSIAWNDESSSTSSSFDDIKLQFFQCNETMPTLNNNNNNSSSSRKKCHVISVLESMQVISKWFSSKLLQKLKEKPINEPKEWRTTLNLYGTHKCHNENSECIFISGLGMYRGGYQCRCKIGFHSTVTNLGPKFNGTLMERSYQDKQDGKSPAYDYMFKCEHCQPGCDQCQDNSPCLSSYNYAFRISLLTITILCIIFTFILALNIYRYRRLKVIKVASPIFLCITLLGCASMYIETIMIFPVMNTTTCVLTKWTRNFGFCLTYSSLLLKTWRVSLTYRVKSAHKIKLTDKQLLQWLFPILLVMVIYLGAWTISDTPKPNYIVDWNNLKFKQCDYSWWDHSLTIGEFLFLLWGIKVCYNVRNAQSLFDEAKYITWAIYNITIVNMVVILIHIFILPDSGPDIKYFFGFLRTQLSTTTTVILIFGPKFYRVIKGEGDLWNPRARCMMADTFAFNNGIGLAHEETTDLYQENDDLKREIQKLAAQLELMKLCQMEFRNRHLNNHLKFSRIQQQQSQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L450</accession>
    <name>A0A922L450_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ACP7_3</name>
        <name evidence="7" type="ORF">DERF_008261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L450"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038170502" description="Purple acid phosphatase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="6">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="128"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="5">
        <location>
            <begin position="377"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9517603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="452" mass="53261" checksum="631F006F2D191C26" modified="2023-02-22" version="1">MNKISMITILLAATCCCLSLVHGIEQVHISLGTNATEMIVTWTEPQKHTDIDIDAVVYYGRASSSFDQAAIAKSEYFKDDETKYTTFRALLTGLESDTQYHYKIQLDDKESSIFAFKTLKLDENWLPRFAIYGDLGYVNEQSLPYLKKDVEKNMFDVIFHIGDIAYDLHDENGEVGNNFMRSIESIASKIPYMTCPGNHERHSNFSHYDSRFSMIGDRSQPNHQDSLDKRINNHFHSMEIGPATIIMFSTEYYYYTYYGWEQIERQYRFLEKELIRANENRNKRPWIIVMGHRPLYCLKMGDSSCDHQTMERPEIRQGIRMHDQGERQYGLEDLFHKYGVDIQFYGHEHFYARMFPIYKYQMYKGKQSDNPYDHADGPIHITTGSAGNKEIHPLFNHLKEWVAHHFYDYGYTRLIFENQYRIRLQQVSDDQHGKVLDEIEIIKSSPQPHWMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5J5</accession>
    <name>A0A922L5J5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_004469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5J5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052976">
        <property type="entry name" value="Scoloptoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933">
        <property type="entry name" value="FI18007P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22933:SF43">
        <property type="entry name" value="LP10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-2" evidence="2">
        <location>
            <begin position="823"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="38"/>
            <end position="53"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="319"/>
            <end position="328"/>
        </location>
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    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9520779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="879" mass="99297" checksum="A1FF660F11D00873" modified="2023-02-22" version="1">MAPSIIDDDNDDASTTTSPTTTTTTTLSDNENSGQQQDSDSIINGSESSSLLSMPQRARIIRRQRRRMKVRRSNEFDVLTPSDLAMLRLNNKRKLLKKVIKLRKKHIIKEQQQQQQNANRLNNSMIDDSIIMDDITIESTFNQQPSMMNRLDYHQSTSTSFPPPPTTTTMITTDTAVEIPATADMATTMVSPSLLPKQDDNTDTSSSSSTGQMMNIGGLFIEQPNNSIQQQKQQQQQQSSSIESTSSPSTASISAADLLHTEESTSSQSFQHYMPPLFLPQTTTKAFFKRIGLFTNSGYGRSLQSNNDDDNKEITMPMTTTTTTTTTTESPIIIDVNERRQQQQQQDQDDNMIDNNNNGNSINITNAGDDDDDDGREIESINNNDDDSKEILTNSDNNHSSSSSSDGGSSTTMIMNEPFVNVYEYPQVNSNLELIVDNQTRDDKDILDVKSSPEYYQLVDGDVDVVALIPPESESESKQQQLQPNNSSVERIDSFVLLDGKSDNDESIKNRYQPEKSSSSSSSESLTTSTPSTIMDDSEETRGKNSEESTLIKDLWQVNRRNRNKYKTNGSQSDDVTNSTTIPTTALLFERYANQQQQQTINKRPLRIPKLLLPKVNRPAMYSLNGYVPKPSIQRTQMALSEPYSRKNKTRRTRNRQNNTMRKRQKSKKSQRRRNNNNHQSSTLSNRMNWDHSSTIRIQQTLRNNKLTGKNHPNIDDNDDDYSDEDDNINYNDGQQQQQRYDDMIETSETINSHQNHNSLIPSSTGRHRNHQQQQQPSSRNDNDKLPKKSTKSRKPIGIAGATLMHHQHQSTKASLSTIPKTSFECGDKRSDGVYADEETGCQVWHICQNGQMHSFLCPIGTVFNSKNGVCDWWYNVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
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    <name>A0A922L5P8_DERFA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="1" type="ORF">DERF_004594</name>
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    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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        </lineage>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAH9520914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KAH9520914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="10154" checksum="CC3BA98E4B91A43B" modified="2023-02-22" version="1">MNLKSCNFFLLTNHLKFDENFVSFLLHVTKETKSKNDNVERPIWKILLPWIKSWHCSENKTKCNNQRREIKWYAIRYPKVVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5T5</accession>
    <name>A0A922L5T5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">DERF_005045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Astigmata</taxon>
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            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAH9521381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="153" mass="16651" checksum="0772F64AB47DEF71" modified="2023-02-22" version="1">MAQTKRKGRSPNDDMERGMKQPRDHANVTSLGKASTQGTSKQPNEPLITIDDTSDSGDDAATFSSIPESNADKKILTTTITNVEPAQLALKEFMDVNGTIKDSTKLRVIAALQTVSAFQQEVLTRIVKMMAAQRYLNLGNVESIVGNVQNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L671</accession>
    <name>A0A922L671_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group xiia secretory phospholipase a2-like protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">DERF_007642</name>
        <name evidence="2" type="ORF">HUG17_2006</name>
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    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L671"/>
    <dbReference type="OrthoDB" id="3935740at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010711">
        <property type="entry name" value="PLA2G12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824">
        <property type="entry name" value="GROUP XII SECRETORY PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12824:SF8">
        <property type="entry name" value="GXIVSPLA2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06951">
        <property type="entry name" value="PLA2G12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038277017" evidence="1">
        <location>
            <begin position="23"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7646468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9516929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="191" mass="21422" checksum="88D919986CB7BE52" modified="2023-02-22" version="1">MEKFSLFIVTLLSFNQIIPGEAFLEGFAHSISQMNEQLTKFMEGLQESVDSWADKVLDNAKTEECFYICPKGQDPIPKPNYTHTPIGCVTFGMQVKAEDLPSKSMKICCDQQQICYHRCNSTKIECDNGFQKCLHDQCIEISHDNKQVVVCETATKLLLMGILSFGCKTFKDAQRESCICPPVDTSATGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6A3</accession>
    <name>A0A922L6A3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6A3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="90" mass="9843" checksum="2C863C004E2F410C" modified="2023-02-22" version="1">MYSVMDEFQKKTFVAHLLTSNQINSESSELSTVVVLFESESNGELRISKNDDRPVCGERGGGANDANTDDDDDDDDGKPTTTLPLIKSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6Z9</accession>
    <name>A0A922L6Z9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Bromodomain adjacent to zinc finger domain protein 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BAZ2B_1</name>
        <name evidence="17" type="ORF">DERF_008458</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WAL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15545">
        <property type="entry name" value="PHD_BAZ2A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000199">
        <property type="entry name" value="Bromodomain adjacent to zinc finger domain 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915:SF2">
        <property type="entry name" value="TOUTATIS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MBD" evidence="16">
        <location>
            <begin position="884"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="15">
        <location>
            <begin position="1203"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="2138"/>
            <end position="2188"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="2192"/>
            <end position="2239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="288"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="480"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="596"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1008"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1408"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1600"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1704"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1981"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2242"/>
            <end position="2381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1079"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1481"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="303"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="548"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="596"/>
            <end position="610"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="632"/>
            <end position="647"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="667"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
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        <location>
            <begin position="1409"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1420"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1602"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1635"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1728"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1747"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1758"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1987"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1998"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2010"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="2242"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2268"/>
            <end position="2289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2290"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2310"/>
            <end position="2349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2350"/>
            <end position="2364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2366"/>
            <end position="2381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9517829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2409" mass="271753" checksum="A9C7C1D3E3C744A5" modified="2023-02-22" version="1">MILYVCKEFYAISTFQMLYILKLIEINTIVFGQSVLDGNTKVFITINHNHNQQRKPQQQRQQKDHSSLVSTTTTSFTNNNNNDDDDDVGNDLAVNVIASSSSSSITSTITTTTTTTAAEIVKNIQQPPPSLSSSITTTTTTSSFLLSSSSLPLPSYYCSTNLFTNNIAQQQQQQPITTLSPSSTFSYKNNNNSTSKFLSPSPSSSSSSHQSVKRSILYEHLLKELSPTPLASSSNALQNHSNLNINNNNNETFEFFLPISSASSSFLNNNKPNSVQNDQYLSSIINDTKKSTKRKTQRKQKQHQQQQQQRNNNRSSMKNRVNRNNKNSDGLINNNSNSGRNKRKSKKQELLLQQQQQQEDSILESLPIQVVAALLLNQQQQQQHHHHQHNNLTATTNLDQNNSLFLSNSSNLNNFIIGNDINSIGTSSSSTTTTTTTTLTTTTTNTKTIVSDNIKELIKIDNIMNLSTKQSPMPIALTTKTTANNSNKNNNNNSNEDDSSIPLNLCVKKSSSSSSSTSSSSLSSNNSNNNNNVSSLQHNNFGSNNNKLHLHHQHHHHHQQQQLQQPDSHTLNLVKNLAQLQQQQNSQQQLQFNNSLLSQQQQQHQQPQQQQKKRGRKPKSTLMAYGDPQPHPTQTHHQPLLQQQQTPPTLPLPDFSGFGNLLAAFNQQQAHLQQQQQQQQQQPRKRGRPPTLSPPHNAHQNSLANSKLATNQQATSAFHQNTYPFNLFNTPAANDGIIPNFPGLNALSLAAAAALAGGGQLANHQLFNNAVNQFSILQKLNPNLLNANLFANLKNPMELAAAAAAVTANSNDIVNNKHSSASSSSSSSSKFVDPALLLQKELNDQMQANFLSSLPAAVAKNLIGDQSGGSNTSMNKSSFAHKSNSSDKQLRISLNHGFQRFTYITGFSKSGTIEGDVIYIAPCKKKIKSYQDLIKYLSKNNVVNLSRENFSFDPNVIIGQFIPNIAQLPSDVILSENQMKVHLEELSKIRNLDLSATSITAVPPQQTIAQSNQNNSSSNHIIPEKKKRVRDSGGTRNVYDSIKGFNTRSKTAAVVHQNNDIKNNELEPSVTITIQNPMLERKQRELKEKEEEELRKIKENQEKLLELQKQEQLKISAEIEHERVSQHQMFIHALNELKSSEDRDSKKEELSSEKVALQERKLLKRVLEVELLKELKKPVEDMMLKDHKNLPIFNRIPGQKLTGKAFADLLMVYEFLYNFGETIGFDVDSLPTLNSLMMALLNLDSEAEEELMSIVNHLVICAIEDPGMPNNMTTLMGQKLKDATVTEHNVTEILRLYFLAFSNAVREEDEPNRVECKIHERLCSGISFIALDAIVKLDILVFLCNELLCNQAIVKQIDDSIESVTVFKKDKWGIENDIRKFRLVKMRRERIIEEEKAKQLLLQQEKDNANTNQSATTMAENGGENNVTNTGENTTGTGENSTVISDNDESNTNVSAATLSNSVTTINLPPIEFDDDVNMTNEEIDKKIERLNKQCNQMNNKMHKALNAYRVFPLGQDRYRRTYWVLPNCGGVFVEGMESGEPEELANNVWTEEEIEMENALKNAINDEPMEDLTTGDGEIKSELDKQSMNGDNDVEQTDTMSIKEENDDRDNAYKDVPSTDDEKKPIVDGQQVKPEMEPKMEKDDALKTESNENEMTTTNQMDKKDELSESEQIDVNNAQQIDHITVDDVRWFDLDLDFECDQSVEQPPIIDESTTVKEKDDEETAEEKETNEQEKDDQNQENKKEEEDDDEEEEEIAEIKEEPMSEMEKALTTFMSQDTLDCLFKRTEMNIDCAILKDCLLRILSSFARSATITKFPNSEVIETDIIVCPTLQKRIQLWKVLQYETPRKVPREYQFGWWRITDGAQLKSMIELLHSNALREKNLQKHLIKHLNYATISCRNSIANLDVSDYDRDASDWREFGAPTENRCPHRSCMGKNYCHEVALRKDLQVLELIEAFEEKILSCSMQIRNWKPSNKLSSADFKSKLNQNKSSKTNKNGKNRKNHKNNNNHNENSDCSNDSIQENGTNGCTLVISTENNGDYDLLRVQKEKLLEIEATIERRYLKPPLGFKNNQALQFTTDNGNGGDDYNEYANDDNATAGLIRWRDAAREAKCCSQIAMGLHFLENCIAWDKSIMRASCQFCGSGENEAQLLLCDLCDKGYHMYCFKPKMETVPAGDWFCYDCQNKNTIDKVCIVCGKKGKLLNCDTCAKAFHPNCIDPPVNKQIKGRWICHMCMRKNKRNSSSKSSKKSSSKESSSANDDRNHDSNIMGNNSNTRESSSKRMSNGNAKDKGEKETANKKERKPKKKQDKEKDNKDNKDKDEDHHLEKEKSEKNEKMSNKKSMEKECSNNSNANNNGNNMAGTMEQQQQQSLATNSSSIKNDEIALCKQITDEIMKHETSWPFFGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L704</accession>
    <name>A0A922L704_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cadherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">hmr-1_2</name>
        <name evidence="16" type="ORF">DERF_006280</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000058">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000092">
        <property type="entry name" value="Protocadherin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056370">
        <property type="entry name" value="Shg-like_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF438">
        <property type="entry name" value="CADHERIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24811">
        <property type="entry name" value="Ig_Shg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="322"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="434"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="574"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="772"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="886"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="13">
        <location>
            <begin position="1386"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1716"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="13">
        <location>
            <begin position="1778"/>
            <end position="1902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="138"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="281"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="553"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1022"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="282"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1744"/>
            <end position="1753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9522716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1902" mass="220008" checksum="0DAAAED20123439E" modified="2023-02-22" version="1">MKIFLVRLGHRIHLDHHHHHPYPTTNRSRFRNKNKNRITGTTATTTTTVIDDRNNDPIDYDDDDDDRYHHHHSYHRQPNHSTIISLPTTTTTAKSSNPSILTSNTNSYYIKALITPSISPPPSSPTTTIANNVKQLTMNHHHHHQRPSSRFTPLSYNDTKQQQEKISKQRPPSSSSSTSTELLNSNNKKKKKNNKMKTKTKKKPIPMNDSKIFFYNNNEQQQWPMIPTFEIEINEEDDHSLPKRLLQAFNVNVLFITLTNDDNTNIIIDQEHFIRYFLSPYIDDDDDDDDNDDYDDDDDDVDDVNFDNSDNDDMNDVDDNGDNDHYSTIKTGKMTGSSSTKRFQFQQKHQQQQQQQGNKRKKQMQQTDYLDSFTINHTNGEISVLKPLDYDYPNGQPTYKLNAYAQNIQTKQQLGFANIFIHLRNINDNEPFFQQNFYEANIMENGPTNMSIIQMNAIDYDDYYDRDQILQYSIINNHYNNHGQSLFYIDPNNGLIMANVCCFDREHRANYTIIVSAMDSGGLKANTTVNINIMDQNDCPPRFIQNEWHIELDENDDDDGDNQTDQSSTTTTTTTRTRTRNSTNNSFQSKMLLKLTVNDCDLPENNYFTYKIIEEKWSSKPIISITDDQYYQGQQNEFITGHYFSIEPSSSMMMTNDNDNGDQYKQHGRLLMNKTTGIYGTETSALLLLNKPLDYEIPNHRFIMLKISVTDIDHHSDMVDGNGGEGIINVNDEKMTKQQPQPVDNLMTKQHTDICYIYITIRDINDNKPKFLKNFLNITIPESFPVGSIVAKFHAIDPDRNHTDDLSKSIENIDIYYSLDEQTNQRKYFQIDTETGTVRLNRKLDRETIAVHIVKIIATDLDDPPLTSIATLVINVDDVNDNAPFIINTTILSIRENQHPQQRLGAIYAFDRDDYSKGNGPPFTFRIDPNATEMIQQKFRLEYIHNDNDDDDDGHAILFSRQTFDREQQKQYQIPIIVNDSGYPSLSSTSIVTITIDDINDNDMKDGWKNVYVFYIDQQQQQQHGKQRKIKTNDKNVNDDDDDDDDDGNVDESPITATNQAKSLYRPIELGQINVEDPDDWDVGDKKFSWLEEPPSSMATATSSSNVKNDFYIDSNRGQVIARRKLSQGLHKLKFQVFDRRYQHMVQSTMNIMSKSLSFDVIINSGSLRITKPMDVIEFIKIWDWNQRRKITSHKERLELCLKHLFDCDWLAIVSIKSNAKHSSLDIRYAARKNDQYLSAVYLNSMARIAGHRIRMETNLTISQFGINECMMSEQEENPRQHQCIESSNGCMTETLIDWTNPYELIDANFTSFIGINIVTKIKCQCFYDHLLTYLVDYKFDCDIDQTLCQPPSSLSSSPMCYQHDRINLFTRSLMTSITNLNFRSTNIRSFKSDGVIWLDPLPICSHSKNVFSVQISTTDPNGIIFYYGPIISSSSSSSSMYEAGIEQSDETDFMFLELVNGSPRLLFDFGSGIQEITINIENGHLNDGNWHQLDIQFDSNSVHLMFDACIHHFHVERSSSLNNDDDLYHYHHQQQQQHYKSSSSSSSRYYMDIDRIILMEKCQNYSIITKFQHVLNVNSPLQLGGIELLTTKSMNVSKMMLKNQEQKSKFTSTDFNDDDDDDPEKSILPPFIMSAIFNQPLPSMESSSSILHSSSYHHHYYHHKPPAPPSPSSSTIRKRIVGFNGCMKNVIFNNHIYDLINVHHSYNTQIGCHSSQSLCAFLDKKCLNNGYCDGSYNHVKCYCPRGFYGEQCEQIDRPILFLQKSFLQLSLKPMNSDLMQQQSTFDRTEFYHTDYDNGFVTKIDFYFRTRQWQNQIIKLIGQANNVRTYCLIEIREARIVFRFNLHPSGIKSSEHRLSIDSFLVNDGRWHHVRAIRLGQSAQLILDNGGIGKIVRYFPPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L772</accession>
    <name>A0A922L772_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L772"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9515892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7571" checksum="CD524BA2BA36CF37" modified="2023-02-22" version="1">MAHNRIKTDIADPLFFILNSRIAMKQNNPIERSINLNQKFIVIKMLMPVIDSMVHIVKFYRLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7N4</accession>
    <name>A0A922L7N4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">microsomal epoxide hydrolase</fullName>
            <ecNumber evidence="4">3.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EPHX1_1</name>
        <name evidence="11" type="ORF">DERF_005932</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol</text>
            <dbReference type="Rhea" id="RHEA:55764"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:139161"/>
            <dbReference type="ChEBI" id="CHEBI:139164"/>
            <dbReference type="EC" id="3.3.2.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.9" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7N4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033961">
        <property type="term" value="F:cis-stilbene-oxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="10">
        <location>
            <begin position="63"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="460"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9522353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="490" mass="57210" checksum="5A3ABDDC14168CA0" modified="2023-02-22" version="1">MGCCCKVTTLFLLIVAGFSLYQFYPCLFKCHDKPNFDTFKVDDWFGRVMLKANQKIPKDPVDIKSFRLNVSDADLNDLHDRLKRSRFIDHLQDTHFQYGFNSDYLRVVQQYWQNSYQWRKHEQQINSYPQFTTQIEGLNIHFFHVKPKTTAKVKTIFPILLVHGWPGSFYEYLKSIPMLTEPDSNGYAYEIILPSIPGYGYSEQPHKPGFNIPAAARIFVKLMKRLGHEKFITHGGDWGSAISLAISTIYPENVRGLHLVGNFFQPSTFGDFRRMLMAYLMPKYYFGTDDWQRQWEKTFPFCQKFKSMLLETGYMHIQATKPDTVAAGLADSPIGMAAYLLEKFSAWTHANYMELSDGGLVDKFTMDELLTNVMIYWTSGNIAASQRFYLENMQNFKFMQTLTQAQVKVPSAIIEPTHDLMRAPRKFIEHLHENLLQFTDSNVGGHFLAFEEPNIVVKDIRQFSKKLLEFEQQKRKEEEQEQQQKKHDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8D4</accession>
    <name>A0A922L8D4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8D4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="95" mass="10686" checksum="2A2E17B4B13AACE5" modified="2023-02-22" version="1">MIEEYTDILLIYNDHISNNNPGTSINNQQKQITGPFRTSKQNNITSNLLHIIRNGIRFCVVGLITSFICMGIVTPESVGTLILHPHNACNNSREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8I6</accession>
    <name>A0A922L8I6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">COG3</name>
        <name evidence="12" type="ORF">DERF_005274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8I6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="58"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="220"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9521637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="751" mass="87557" checksum="CD3DE9550721E7E6" modified="2023-02-22" version="1">MNSNFLDRWERDDADSLAPLSTNQQKFIDRLIDLIKFYKRYNDLENEIHIQSDERFRKINEHHRLCMQLTELVGEILASLNRLDEEYSSVIDKTKSFYSSCDTLLQQQQNLLVAIEAINEKLSYFEDLETMSKKFSSPTMLTLNESLIPLLHRLDECIEFMSTNIDNYLEANKYLIDYRRFQTSALNTIRTHVINTLKQTETQVMPENDTVLTSNESVFTLYYGKFQLNAHRIKTLMQQIENRTKQSETFNQFLNDCHQCYFQIRDSLITPVLTLAMDEMIQTSGRNFCSLIRSSAKLYTHICRDEYQLYFQFFTQVDHSLGEFLDQLCMSLYDKLRPIIIHLEHLESLSEICSLIKFEFIEENLHQDELESFVKAMQQLLQDTQERLVYRCNVHVEKNILNYSPASGDLAYPEKLEMMKSISETLETNNVQNNTNEQEQTSKSSTGVMKRSDSVSSIISSISDISFVRGYHHPSESSRTVSSRAIVDLHGMWYPTVRSSIMCLSKLYRSLDKLTFQGLSQEVLLACIESLESALLQIKQRKGPIDGYLFIIKYLLIIREQITPFQIDTSIKEVYLDFTRTKTAVIDLLQKRENLFSLTTNNALLKLIFESSPQVSEKVIDSQKAVDNKIKEKCEEFIMFSYEYLTADVRNFIVNTKFDFTANQQQPSPTPSEIQLEQLKLKLQESIQSYLDRKESLAKSMSLYLANVETEAIIFKQINNKIQELFEQLSRILQSKFPTFERSDLPGLLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L921</accession>
    <name>A0A922L921_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Activating signal cointegrator 1 complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ASCC1_2</name>
        <name evidence="2" type="ORF">DERF_001110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L921"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="234" mass="27827" checksum="2A90157EE30A36BB" modified="2023-02-22" version="1">MIMRQASTMVKNRFTHLITIPFVNDDFIQAYLDFKHRILEDNPDIDEILFQNPKKLHMTISCLSLDDQQRLTMARELFTKQCSDYVEKFPEILDNKIQIKGVDIMNENPRKTNVLYAKIENENLQNFANNIADVMVSNGFLYTGDRHANLSGRQNVKLHLTLMNSSFLFRRKDFSLKKRKPMKQRYFDSTEILNNYRDHFFMEIPMPPVQLNELHRINEFGYYNVVESIHLLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9F9</accession>
    <name>A0A922L9F9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9F9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8334" checksum="B67814DD8D449B4C" modified="2023-02-22" version="1">MINDNYQRPGLRPPGRKKSCPKLSPPRNEFSQSPPGKPLKHSIRLISKRWLAANAIGCFARFPLLSFIDDDADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA78</accession>
    <name>A0A922LA78_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1449"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1514"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1607"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1716"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1848"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1949"/>
            <end position="1974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2087"/>
            <end position="2107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2344"/>
            <end position="2373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1319"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1522"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1577"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1769"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1797"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1808"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1858"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1905"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1957"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2087"/>
            <end position="2098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2353"/>
            <end position="2367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2373" mass="262849" checksum="084687CCDDD1ADB2" modified="2023-02-22" version="1">MFSKYSNIRISKNSSSAVENVSLNLTKESFYPPLSFIQKSDPHRSFISARFEITDDCETSPLSSTLVGCCSSGSECCCSPSPLVPTKEALTSCSNLNSSFQSNFYDSHNKFIMTTDVTPTMAMTTCTNEQSPSSITARFSDPLGSPPTVSSGFSDDYYYGPSSGEFSSSANGDSMSINPPPLSCNDNNYWALISKNDNFQLKLESRENFVCFIGSDFVLRQQKQIQSSSNKKNKDDHQAVLIYASGSFHLKDLDSKFGITSYIDITFVNELRVRSRSFIRLNIDDEIRFGFGPDIYQLKHLPLNQINCNHSPHIQRVNINKDDENHYRSTTPLTTMKNDNINEFIVLGNEHDNVSVNNDDNKQLKQNSISNPLASPTAFKQSPMNKLFRISIRKNDKKSDPVKRGSKKNAIQASTSTASSASSSSSSKSSSSHNKLSPSSFSLMSSSSSSSSQSSTPVTLTNYTQQPTSSSSSMFMSAMKMVKARFKKKSSSATVSAKDKKESVFICSGNDDITFIRYRHNFEKNHPPIHQQNKIEPCSISAPESPNQSRHHVYHSHTYQNTEFLRKLSDDYPFTSHSGFPFITDEHEYDEVTPDLNLDNDADDDEEVPSCCSDVSEQQWTCESKASTNVDDNNQHFNHNHHTLCPSTPLQLLQPNSPSLKTKHTSVMNTATSVQQDCGLYLENHHHDIIDTDEYNASHSHECFDVENHTSTQAISTLSTIHHLPHLNSEDRLNNNSSLDSNIVHFEYLKNLKNNKFESNTSSDIKMDSCEKSINSSTILFDDEKRTKLHQQESNDESFCQNNVIISPLSSSSSHQQETATMTTIETTTVTFGSTSSLLLYTSPKQSSVTSTTSTINNHIQCSDCNVQHRVDYICQNKLERQKDKIVFSGDDGKCRGSSINFSYSASAVGEKEQVNSANKTLFNFEQWLPLTTTTVETATATASVNETTLKHRNNIEQHLNQLNNKSIHKHSGRQQLVVVPVDSDSGAVTDADTNDLYDIDDIGHLRRGQRRPSSSSSSSTKITSSFDHYHTGNLLASTSSGQSSLGTSTTLANLNNHNESQSSSLEHDVEFDYQQQHGNCTKTPQPQSLPVFMQQPRSRHSIGGMAFVIDFNDNVSHNKTHYSTCNNYNKGQKDNRRPSPLLFNNPNTNVNCMSDVEQQMTNVSPHTGNSNTATNDITITATSVKRLSNVTSVPPTALNKTNIAYVFDVNDMNDKQKPSIELSNDSGHTQYHSSSSMKKSDTYDKKINKLLANDMNNDKDNLVKNDYQKNPNNHCSVTIPLSSTTEINEMSKNIETNSNRIISGVEMIDDDKSRHSDATLQQSTSRRSAQLSESAVYLINRMFEHNNYQHNPHHHRSNSTNSHGCYDLGDDVDFDNHHRPEEYFDGGEHYGHIPHANNVKPSIKTSATKTTKPHLIAKSPNSHSIEYDDDSLSLMNSIKDRSHTLAVQSHRSSLHRHTPKSSVSDSADTMTCMDKQLIDSNINIVDDDGELSDTGTYVIDIDELTGEKLRRKSENVMNSKKTIHKSSTKKKSAQPKHQLADDDDEIRIKSSDGDLGVGSGPIARCNDGEGGNGETNSDEFGYEEDDDDDEDKLEVARKQIDELFSNYEKQKKNSSHQPLKKDATFTRSKRRSSCSEVNSSSTYHNDKSCRPNQMIGVQQSTQLFNVIDDTVVHSKNTGDKSKKRISSELMSAFKRINSKLEKTARLGKLSLLSSSSTSCTPLVGTDNTNTNDDNHHSTKSVSAQSKLPIKCRSAPSTPLLDDRKHSANNRLCSRNINGKSRISSAIPNNEYSSSTERIDNDDRQQRARSGSITSSNSASSSLRFNRAFALRRARLGMDTCGVEISEQSANKAKESQKINSSKTTKLSSPVSFKRNDGGRFSLRVPGARIPFNTCNQSTKGSRKPPSSSTTVVPPTNRKVLKQSPVSSKIPTLKSYSASSSVCSSIENLSNGPVKGKAKDSKSLSSIDHRNQSQRRVIPHSDNEIQFDAECSSCDDGEILTYPALPFTRFGRRSLRFMPSSGCNENSTPWLKSLSNKSVDSNADIVNKRNKAEIQPQPINQGSYSLFGGSRRTSSANSYCSESESQNYSSAIEPSSPSIVDPRTARPIVPPFQVGKRFFSTKPHRMAQFDKDFNTIIHGHHSASANPSPMRQLSADPNLMTHSVTECLLSDRSSIDGKRQEIKSNEISAASTAIASSINARIFSISPLDSLVISAIINSRTLIDEILPQVNTNGNGPDSSKSNQIRNNYNHDSSNISRDLSNILKNLKKVEQIFDVFSMVVEPYTNESKIVELHKTDGPIITNASDTDTSGSDDGTNGSVVIANCTSTETSINRSRRSPFIIPTQQSSAKAFSQSPPSSESLSQSRSGFFIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAG6</accession>
    <name>A0A922LAG6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAG6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7832" checksum="EF0C459AEA908C12" modified="2023-02-22" version="1">MGVVAAATDDHQFKSNCPLSPNGSRILSKYKTRQMDRFRLFTEFFLEYDNIESLMEVLINDNMATFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAQ2</accession>
    <name>A0A922LAQ2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SURF1_2</name>
        <name evidence="7" type="ORF">DERF_004973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAQ2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9521305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="210" mass="24769" checksum="47C29C733C2CEAC1" modified="2023-02-22" version="1">MNALSLNFRLFGGKTIYIHMISSFRSIKPQLHHVQCYRHFNAKNKPPPNNNKYKKQNWTIMDNMIQAARNVWIVPFSLAIYNGIKQYKNDRQKSDSTLTIEDLDKIPPVELPNEPEEIQRLMYRKVKLRGYFEHDKEFLLSQRTNLQLSDNTNISPFNRSGYHVLTPFVLENGRRVLVNRGWISEFRKKPESRQSGQIQGIVEFQCLCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBT7</accession>
    <name>A0A922LBT7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">dCTP pyrophosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">DCTPP1_1</name>
        <name evidence="1" type="ORF">DERF_003795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBT7"/>
    <dbReference type="OrthoDB" id="411123at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047840">
        <property type="term" value="F:dCTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006253">
        <property type="term" value="P:dCTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052555">
        <property type="entry name" value="dCTP_Pyrophosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46523">
        <property type="entry name" value="DCTP PYROPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46523:SF1">
        <property type="entry name" value="DCTP PYROPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="129" mass="14920" checksum="9C7156DC9AB0A08C" modified="2023-02-22" version="1">MDDKFDGFKFESSTISLEDIRQQVIRKTKSNVNQNPRNSFLDLVDSVSKISSQFRKQTDDDCQVGLPKWTNENRKSLAMAINETVENLVRLSNDCHIDLANAVVMKMEQNDRKYPVKKVYGLAKKYDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCL4</accession>
    <name>A0A922LCL4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_000700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCL4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="71"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9526630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="343" mass="40470" checksum="F4DE9D64CD0D87E7" modified="2023-02-22" version="1">MSKDVEHSNKTRAIESETTRLRYFRTNNRDIKISKLDPKQGIQQEIDQALEYRKSNQLRNDHQRELLDKGYRLRNIIGSGSYAHVFRAKDLRQSCDVAIKLIELDKCSRHYKDVCLRNEIYVIRELSHENIVHFYEAFNTSLAYIMVMELVDAGTFADLLKKNGPISDDRARRLFKGVFFGVDYMHQKFIAHRDLKLENILINKYGQPKISDFSLSVIWDGRRLVTDWCGTPPYFSPEILQGIPYNPLAYDIWSLGVCLFIMTNDTLPFMFVDYQEMLQKQLNRDWKFRTRYERNISDDLKQLIRAMLDPDNNNRIKITDLIQTRWFRGGGGAVIDTRQQICY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HH59</accession>
    <name>A0A922HH59_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014232</name>
        <name evidence="2" type="ORF">HUG17_4133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7640100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HH59"/>
    <dbReference type="OrthoDB" id="434989at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF127">
        <property type="entry name" value="SPECKLE TARGETED PIP5K1A-REGULATED POLY(A) POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="1">
        <location>
            <begin position="223"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7640100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="544" mass="63426" checksum="82E79FB23BBE97DB" modified="2023-02-22" version="1">MYGSIVFWPSLLNDKLIWKTSALLGRKFTTFNQMIVHNKRLARRSLLVEDGTANLRHLWLKDDENLNGQLFDSRAESIIRWRIDSNGSIQGGPHSKRFFLVQFCDDQHYVNGCQYLQSKYGTTIHNNVCFLTNDRRTWPKVSNDKIKIFIQPDILSNCSIDRYRIFRADNNHLIGQFDDYLLKPATSMRYKQWFERQKIKPSDSRITHLISKVMQGQHLIPISQHRIRFLICQQLEQLFQSKLSKRTSSNQFRLIPFGSDVSGFGMEDSDLDLCLVEDGGQHKVHTHRSVRILRSLSSTMESTIKINNRLHVKHFKQIQRIFRAFVPIIKCRSRLMPSLNVDVSVDTECNSGVQMAAYLHYCSHSCPSVRGLILLLKFWAKHHGIIHSNPGEWFSSFQLTILVIAYLQSERIILTINDWENQIYSSQTAIEKRDADVSDQILQHVHGFFQFVIEYNFWTQAIDLRTGQIDLAKPLTSKTSACYVINPFLTHLNITKTVSDAELERFLCFCKQSLQLMQRNDFQCIDLFTGRIDDRLYAYTNINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HHJ2</accession>
    <name>A0A922HHJ2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HHJ2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="135" mass="15478" checksum="5732E4523FDC59AF" modified="2023-02-22" version="1">MCTWLVQYCYIHCHTTPMTTKTWPSTTGTGLARRIFWPDFDLPTDISSVCLHARPPDEHRESITDQRIQTVGNDTGQTTFARTGKIRLQCTGTCILSGTNISMVGPHVREYRIKMRIAFNHFEFGKNSRLDHLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HK57</accession>
    <name>A0A922HK57_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HK57"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="107" mass="12542" checksum="9228B43545A277E3" modified="2023-02-22" version="1">MSGSNDFALMMTCHMWSESNVRWPIVGNHNHNNDDDDGWLVGYLVTSTLLIDYVFDIYNQWSSIELIGQFQLMSAMHHRSIKFQLDNKEEEGKKLQREIASAYRHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HM65</accession>
    <name>A0A922HM65_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPS6</name>
        <name evidence="7" type="ORF">DERF_013419</name>
        <name evidence="6" type="ORF">HUG17_6009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HM65"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7643647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9497427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="246" mass="28289" checksum="F93612C3C3B3B93B" modified="2023-02-22" version="1">MKLNIADPQTSAQKLIEIDDDHKLRIFYDKRMGQEVEADSIGDEWKGYVFRITGGNDKQGFPMKQGVLTNGRVRLLLSTGHSCYRPRRTGERKRKSVRGCIVDSNLSVLSLIIVKRGAQEIEGLTNVTIPRRLGPKRASKIRKLFNLSKDDDVRQYVVRRPLTQKEGKPQRTKAPKIQRLITPRLLQRKRRRMALKRRRSEKRKEQANEYARLLAERQKEAKQAKDEARRRRSSASSGAKASVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMA1</accession>
    <name>A0A922HMA1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_014530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMA1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF35">
        <property type="entry name" value="FEZ FAMILY ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="406"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9493802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="436" mass="51249" checksum="73618F8F742486A1" modified="2023-02-22" version="1">MNSSTQPSICITSSNNQNLADYLVEIPYNEFQQLQQQSMISGHNVDHLNYSIQQQPLQMNSNSNYIIYPNTSPIMMTTITTTTNGSNNLSIPGSVQQQQQQRTCSAMTKVNMNHMNMNKNPNCQFQRQQQQQYHHHHSIYPSNYSSTTMIHPNNTMNINESNYEPNDEFEIRKTCSLQLKELLKSTLEKMYSTNSQNCQLFLSKIDSLEKRLMNRLQTIETKLANCSRLFDSLNEDFMEHQQISTTTTTFPLKTITQKWHDKYTIIPDEIQDNDDDNLTESNSNQRKVNFKFPCPKCSFGFDEKHLLDRHIRTHVPGRDHVCEHCGNLFSSKYKLNCHKVRHTNDSRFKIKCPQCDYSSVDKQTLKRHILIHSDEKNFHCNHCERRFRTNEALKDHQIIHLDQSPFRCQHCTSRFRRSDYLKMHILKVHSSKEKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNM9</accession>
    <name>A0A922HNM9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNM9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="367" mass="44181" checksum="89229772DDB3531A" modified="2023-02-22" version="1">MSIIRWFIMEMFPYKNLDCMSVYLHRTKDIRLMIKNDGQSSSCDSARLINKLICYQILELIRYGFIYAMPLSHKQRIVMFDIFYLYNMSNLMNILAIIVTILGIYLLKKLYYELPERLSTMINWIVFKKDCRYFIHKNHKQNNVCCYIRGKLNESIMQNQIFVICLDLFTLYSLYIAINFIVYTERDYFLVMDQYYESSIWMIIARYVKIVLRITILFINVIVFDCANIMMAHCYMFIIYLFVFISYTFFLKLDQINQILNIVQQRTKIKMNPIEYRKTLLYFFHLHGHTLDHMNRVGSYESDLFTGYLIANLPMNLLLIITTFFLRKNQLIEQKGLYFFCTLVILQQIIGFFIVHLLCTIYTIKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQJ0</accession>
    <name>A0A922HQJ0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein lin-7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LIN7C</name>
        <name evidence="18" type="ORF">DERF_012688</name>
        <name evidence="17" type="ORF">HUG17_8734</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
            <tissue evidence="17">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">Derf</strain>
            <tissue evidence="18">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic density membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the lin-7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQJ0"/>
    <dbReference type="OrthoDB" id="10056216at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097025">
        <property type="term" value="C:MPP7-DLG1-LIN7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06796">
        <property type="entry name" value="PDZ_Lin-7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000039">
        <property type="entry name" value="Lin-7 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017365">
        <property type="entry name" value="LIN7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051109">
        <property type="entry name" value="MAM_complex_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14063">
        <property type="entry name" value="PROTEIN LIN-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038039">
        <property type="entry name" value="Lin-7_homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 14" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="8 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <keyword evidence="5 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="L27" evidence="16">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="15">
        <location>
            <begin position="98"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH7637630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KAH9501879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="201" mass="22733" checksum="E5A5DB5BE82B26DD" modified="2023-02-22" version="1">MASDRLNLENDVKKACELIDKLQKVEYNAWLSSNSSLEKLVTLKKIFESDFFNAVREVYERVYETVDITGSPDIRASATAKATIAVFAASEGHAHPRIVELPKTDEGLGFNVMGGREQNTPIYISRIIPDGVADRHGGLKRGDQLISVNGVNVENESHEKVVELLKSAIDKVTLVVRYSPKVLEEMEMRFDKQRMRHRKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQN4</accession>
    <name>A0A922HQN4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQN4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9505866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="164" mass="17603" checksum="186D761EE8F8FF77" modified="2023-02-22" version="1">MLTNGQIATTTTTTQSPPPSSSSSSSQLVNKDELYDAQLEMMNGNNNNSSSSNGIDIVNHTATTNGFVYANNNVVPSTTTKLSSSSSSTTNMSTNISSSPSTAASGIVSVSVEQQTQTDMIDPYPLNTSCLQQQQEMINIPNCNNTDPSSMPRFHNQRFHHHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HR55</accession>
    <name>A0A922HR55_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chitin-binding domain type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Cpap3-a1</name>
        <name evidence="9" type="ORF">DERF_011919</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HR55"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037426387" evidence="7">
        <location>
            <begin position="24"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
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            <begin position="194"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
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            <begin position="250"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
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            <begin position="500"/>
            <end position="552"/>
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    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="650"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="800"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="929"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1135"/>
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        <location>
            <begin position="82"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="305"/>
            <end position="502"/>
        </location>
    </feature>
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            <begin position="555"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="705"/>
            <end position="804"/>
        </location>
    </feature>
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        </location>
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            <begin position="82"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
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        </location>
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            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="636"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="719"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="786"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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            <begin position="856"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
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            <begin position="1059"/>
            <end position="1072"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9501051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1136" mass="128067" checksum="E3ACE8278B740813" modified="2023-02-22" version="1">MKAIIALSIIIIIVSFVPNDVDAGKFKCPQPFGYYEHENCWQFYQCSWYTPHVITCPPFTQWDQRILTCRWLTDCERPSFFPTTTRRPTTTTRRPTTTTSRPTTTTRRPTTTTSRPTTTTRRPTTTTRAPTTTLKPTTTTRAPTTTLRPTTTTSRPTTTTRRPTTTTRAPTTTLRQTTTTTRASTTTRKSDNSRFECPKANGRFKHKECYKYYQCTQWNAIEMTCPKSTQFDENQQDCVPIYDCPRPALGYSCPEPAGYFPHENCWMFYQCGNGIGYEMVCPKGTQWNQAILTCDHLSDCERPDIGGTTTTSNHNQTTTTMPTTSTPTTIRSTTIKSTTSNDDDDDDDDDETTTMKSTTVQESTTSNNEDDKETTTIESTTSNNDDDDDDNETTTIESTTEQESTTSNDDDDVNETTTMESTTEQETTSNDNDNDDETTTVESTTEQETTTSNDNNNDDETTTVESTTEQETTTFNDNDNDDETTTIESSTESETTTKGGFQCPEPSGYYEHENCWMFYQCGNGIAYEMTCPKGTQWNQTILTCDHLTDCVRPDMDETTTDSNDEETTTIESTTEQETTTSNDNDNDDETTTMESTTEQETTTSNDYDDETTTVESTTEQETTTSNDNDNDDETTTIESSTESETTTEGGFQCPEPSGYYEHENCWMFYQCGNGIAYEMTCPKGTQWNQTILTCDHLTDCVRPDMDETTTDSNDEETTTIESTTEQETTTSNDNDNDDETTTMESTTEQETTTSNDYDDETTTVESTTEQETTTSNDNDNDDETTTIESSTESETTTEGGFQCPEPSGYYEHENCWMFYQCGNGIAYEMTCPKGTQWNQTILTCDHLTDCVRPDMDETTTDSNDEETTTIESTTEQETTTSNDNDNDDETTTVESTTEQESTTSNDNDNDDETTTMESSTESETTTEGGFQCPEPSGYYEHENCWMFYQCGNGIAYEMTCPKGTQWNQTILTCDHLTDCVRPDMDETTTNDVQDNETTTSNNENEEETTTSNNENEEETTTSNNENEEETTTSNNENEEETTTVEITTEIDLTTISDDNNNDDDDQDTETTTENETTTTSHNQFECPESNGYYPHENCWMFYQCGNGIAYEKTCANGTQWNQAILNCDHLTDCVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSB8</accession>
    <name>A0A922HSB8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_011511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSB8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="383"/>
        </location>
    </feature>
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            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="641"/>
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            <begin position="743"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="422"/>
            <end position="435"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="559"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="784" mass="85829" checksum="BB92F056C5207E52" modified="2023-02-22" version="1">MATSSSTMTISSNDENRLIEWLRNNCLKLLTTANLQQQQAHNNNDDDDLIKDNERKSNLSLLHLLNNDNQRKRQSTTMTMNDDNGYDTFNHDNRNIVVSPVRSQDEQHRQLSSSSSSPAIGGTELNPSERLMIMSTSSSSTINNDVTASASSPSMINSIDGNDPILITAINNGDHHHHHNHHHQPSIVVDTHAIIDTNSESARNAVIYVGVILSFYLLAILTIAIQYYIKHQTLDPFSAYIFGGGCSSSSSSSSTSTNRDGRGSNSKSYNKHRDRRMNLNSNLNNNRIMTQKQQRSSPSSSLLSPSSQSIIGASGPNSLAIQCRQQPLSLQRPLNNSLSSPPSSSRLMLFEQMMMTPTTTMRKFETESEQQHEKTGAKNNLDSTIMMTNFLKPSSSSPSTTTAKKSTTFDSHYSRYNDESIKSSSMANDGLSNQIDKGGGSGGGDSQKEGDVLHSSPSSMIIIHHCDNDDDGNGNNNNRQRQISINIQPTIILSNDSNQIEKQNVDIDRQDEHEKLTIDEMVIDDFDDDDESCIYAHDDDDDDDTTEDDDDDSVEEAEQTDSKFRIFSSKKPTATTTTTTASNLTDMIQTKDPLPSSTITTTTTTTSSRRQILKNLFSSFGSLGSSSTPSPPPSSSSTAMVIDHSNSSSVPLSVQSSSITAATATTTNVQPVVKKILIRSVSLRTNDDGSSSSCCPSSSSSLRNNTNFQSITSGSSSTTTIMSHHDLIYDGSSSDKLPKLVRFQQQQQQNSTITSNQSSSSSSSSIVIDNGHHNHNRRYEETHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSI1</accession>
    <name>A0A922HSI1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_011179</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSI1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF27">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 15" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037803811" description="Angiotensin-converting enzyme" evidence="15">
        <location>
            <begin position="31"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="5">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="7">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="5">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="7">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="6">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) (complex) asparagine" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10 12">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9506446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="657" mass="77592" checksum="D1B47100B87B9151" modified="2023-02-22" version="1">MWASSSSSPSLSSQFSWILLSLYILGSTTTIQILKSEVNYDEILLEENEKIRNERQTIVNAHWNLETNITDYNEEYLTKVNKEYDNFRKRQYNTIKQYLTDEHKRNMTESQWRQFERLGFLGFSVLGENEALQLLKWMQGRNLSLEPDLNKIYATSTNESLLKDIWIKWRDQTGKEIRKHFINYIRLGNKAAKELGYKNIVDIWMFDWENGDDIKQQVEQIVNDLMKLYEKIHAYVRYHLAKNYNVSMPIDGTIPAHLLGNLWGQTWGNLLTIFPSMQLKPDLPSLDKEINEKLKNWTVKQMFEMSEKFFISLGMKNMTKIFWEESIIEKRNDVEMVCHASAWDMFVMHDFRIKQCTEKTLEDLVTVHHEMGHIQYFMNYEERPTVYREGANPGFHEAIGDLMALSVITPEHLTKVGLLDKSRIEKNLEDLNLNYLLRVALDKIAFLPFAFVMDKWRWDIFDDDDDQDNDDKRIDHMNRHWWELRLKYQGISPPVKRSEIDFDPGSKYHIPAGVEYVRYFVSHILQFQFYKHLCQNVTEKNKLYQCDFYENKEAGQQLITMLQKGSSDRWQNVLKDFIGTSKMSSDALYEYFAPLNQTLTDFIVKNQIKVGWDAKVDDYFIDGPDSSSASKTQIVTTMQIFIITTTATTLLSIFFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTS7</accession>
    <name>A0A922HTS7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DnaJ homolog subfamily C member 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DNAJC22</name>
        <name evidence="9" type="ORF">DERF_012601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May function as a co-chaperone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTS7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44733">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44733:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="263"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9501787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="347" mass="40371" checksum="6013609406F74781" modified="2023-02-22" version="1">MTPNNNKKRLWLAYLFLLFGGFFGLHQFYLGRYRHGFALCASFGGYFGVGLIREFWRLPEYVAEVNGDHDYMVKLIEKMRQKSKPSFGIVRYFASIVVADILGYLVMGAIPHEWFSVDDTSDNIISRLLNSILVPVAIAIGVHTVGNIGHYCGPIRWPLIAAYMTAPLYFFNLNPVFITSLLATLAFTRYSLQWRRTPQKSISKWLVTLAMFAYLMLWISWFYFNCTVTDKNDEIIKCRVAVGNFFNSPAWLEFRMVLRNLWDFIQIKGISGLWNEIVEALDPQGEKNALKYLDDITAMYRKLARQWHPDKNRIGDERLAQEKFMAIQQAYDLLSSMRQKRLRKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTY5</accession>
    <name>A0A922HTY5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">UBAP1</name>
        <name evidence="3" type="ORF">DERF_010931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTY5"/>
    <dbReference type="OrthoDB" id="2018023at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1920">
        <property type="entry name" value="UBAP1 SOUBA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038870">
        <property type="entry name" value="UBAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042575">
        <property type="entry name" value="UBAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15960">
        <property type="entry name" value="LD44032P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15960:SF5">
        <property type="entry name" value="LD44032P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="531"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="598"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="642" mass="73774" checksum="2225C4FC1701C2EE" modified="2023-02-22" version="1">MHHFRELNNNIDDVPMKFQDRFIQLLNNVSAIDNSDCDDDDDGDDDDDDFDIDQYQVENYKFDSELIAIEMYVLNEKRKAEQLQRLEARKKEFAEMMANQSSVILSSAPPTIMAGCPNTVGPRQQHQVLDESEQPAALTTGNNRRPSGGGSMLYNFVSNEILKPQPSMNNGNNTNNCDQMASSYNDSEMVSNEKCKATTTTKEMDHHPNHPIRTLVNPKEFENDDSSPFDNVELQSIDEFKELNKVFGALNFSTSSSITTTTTTTTTVPQVPRNSPIQHLHHLQPLNQTAEESNNVITHQAPSTAIPFPLNNYTSYHTNYSQMMTTGHYHQHHHNTFSYQQSPIHNMDTNTNTVMATSNNHFYHPHHYYQPATNPFSLATNNNSNNNNNHHHHNTTSFEMKRSSSEKKDFYEPNNRSLSNNMMTTATTTLSSRSKSVSDLTQLSQMPSSTTSVMTTTIGHHHPQYNHHQNANNLYMATNHDRLLYDRSKTPPSRMPNDIGGYHHHHLSNQQSVHRQTTNTLVANDPYDTLSDDQRKFVDRLCQMGFRRDRIARAVKHMDINDDKKIFEYLLVLQQLEDQGYDCYEAEIALHFNNYDKTKAENFLEILKQMLDFGFDRQKSIKALFKTNNDREKAIELLLKMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU65</accession>
    <name>A0A922HU65_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU65"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8565" checksum="EA03BC77EEA3777E" modified="2023-02-22" version="1">MKKENQFLIIQQRQPPKIVDILRSIRKHSLEIKEVKHVITFMIFKTSQFVTINNTHCKTITCFETFSTISKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUX7</accession>
    <name>A0A922HUX7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="13">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="13">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="13">PHB:PPT</shortName>
            <shortName evidence="13">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">COQ2</name>
        <name evidence="15" type="ORF">DERF_009948</name>
        <name evidence="14" type="ORF">HUG17_0027</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
            <tissue evidence="14">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-decaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60721"/>
            <dbReference type="ChEBI" id="CHEBI:84503"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:44565"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>all-trans-nonaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-nonaprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17709"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58391"/>
            <dbReference type="ChEBI" id="CHEBI:84502"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17710"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:44505"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
            <orientation evidence="13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="13"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUX7"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH7644489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9511490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="401" mass="45194" checksum="123E0401CCB7ACCA" modified="2023-02-22" version="1">MLSSYRLVKNRSNFLYRIFCVESFDNQSILYNNNRYRSIEQCPIIKSSPYICDYQRNCFNPLFDISKTFSTINDPKNGFDYLSGTIASQLVDRLPDEVRPYARLMRLDKPTGTWLLLLPCWWSIGLSTTAGSLPSLSLMTLFGIGAVLMRSAGCIVNDIWDRRFDRNVERTRFRPLASEQIQLNEAIALLATLLGSSLLVLIQFDLNSIILGASSLLLVASYPSFKRFTYWPQFILGMTFNWGALLGWSVNTGGMIDLTAVLPLYMAGICWTLIYDTIYAHQDKMDDLVLGLKSTALKFGSKTNRYLNGFTALMTASLISTGVITDQTWPYYLSIGIMSIGLLRINRQLDVDSIQSCAWAFRQNTKIGWILLFGIITGTFLKSPINNCRDDDADADVGDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV65</accession>
    <name>A0A922HV65_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ST7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ST7</name>
        <name evidence="10" type="ORF">DERF_010013</name>
        <name evidence="9" type="ORF">HUG17_0070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ST7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV65"/>
    <dbReference type="OrthoDB" id="5914722at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11557">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007311">
        <property type="entry name" value="ST7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745:SF6">
        <property type="entry name" value="PROTEIN ST7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12745">
        <property type="entry name" value="SUPPRESSION OF TUMORIGENICITY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04184">
        <property type="entry name" value="ST7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7644532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9511562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="594" mass="68655" checksum="FE75B03EF1A6528E" modified="2023-02-22" version="1">MGLILWNVLTPRFYLALTASSFFISILILLFEWWYFAKYGISFIEQILMNILNPLFGINTNNSSNNTVNNNISQQNGTFSGANSQSSIDSNESDDQQQQQPHQQQPQHQQQQQQSSIVDNRHLMQGHISLDSKVWRNPMSLFRGCEYNRLTMAIKREPLTFYDMNLSAQDHQTFFTCDGDQGHKDMEIMLTAWRERDPDVRIRSAHKALESNPDCAPALILLAEEDAKTVWEAEKIFLTALRAAELQYRKSPTSSSSSSPSTTSSSSSPQQSSLSSLTNSSNHHHHHHQNHYQQSTIDAQHRRDLNVLIYIRRRLAMCARKLGKLRESVKMMRDLIKEFPMMNLFNIHENLIEALLEMNAYADVQALLAKYDDISLPKSATICYTSALLKSRNIGEKFSPDSVVKRGLSMAEMNAVEAIHRAVEFNPHVPKYLLESKKLIFPPEHILKRGDSEAIAYAFFHLQHWKRIDGALNLLDCTWKGTFRIIPFPLEKGHLFHPYLTCTECTDRELLPDYHEVSVYPKKSIPFFIRFTASLCTLTAIMTFIFYQYPVQIVFIVQSYLNWLNELSISIMDRLEFMLPNWAFQCYLTKNCWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVD2</accession>
    <name>A0A922HVD2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVD2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="86" mass="9965" checksum="C8E7204AC5EFA66F" modified="2023-02-22" version="1">MKDAMANANETSMDFFFFSPQTTSVHHHHDHRNENRLLYCMHSPFIYDDDDGDGGPYTKSEKVYSYILISDSSTHYSVQFGAKCYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVL4</accession>
    <name>A0A922HVL4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVL4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9570" checksum="01EDC366DC45D5AF" modified="2023-02-22" version="1">MSRLFTSHGRVQKYQIKDHKYGVNFEFFLLSILKLSQRQEKIKNDPVNMINQSMIVFRNMIDKFLSDIRHGGGATTFTSGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWG3</accession>
    <name>A0A922HWG3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_009451</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWG3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099095">
        <property type="term" value="F:ligand-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="748"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="13">
        <location>
            <begin position="208"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="14">
        <location>
            <begin position="424"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="525"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9510963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="778" mass="89637" checksum="C735E87F6EA0A82A" modified="2023-02-22" version="1">MAHIVANNNKVKRQKQQQQPHLIIYNKNKSHKYRSLIFISCWHFIFIIIIIIMLTFFRFIDANNLSPEMLIKNVIKEQLSRQQQLQPHQPQLHHHRHHMRQSISNGQETTTTTTKGILPLASLTLLPSLSITTTTTSTPPTMTSGFSSTTIPVTAKLRKKKQTTIMQSNNNGHKQENNHQSLEGLIMRAKSPISQRMNNIFDVDSFLPQGYDKLMPPKQNGKPTKVRFHVWVLGLDSIDEGSMTYVADIFMSQSWKDNRLVIPDDIEFNVNASNDPRGPYRLLPLTFIDKIWRPDSFFKNAKEVTFQEMTIPNHYIWLYSDNTILYMVKLTLLLSCAMKFQTYPHDTQNCTMKIESLSYTTNDLVFDWEESDPLVVEEHIELPQHDLISKDIDYCTTDYSSGTFACVQVIFTIKRRLGYYIFHTYIPTCLIVIMSWISFWIKPEAVPARVTLCVTSLLTLSTQHAQSQKSLPPVSYIKAIDIFMSSCTVFVFASLMEYALVNILMADELLNGGFGLNWSCEPNTANPNLTTTTRNRSRSNERQQTESKIIQRSRSGTTKEMLNQRYQQQQQQQLNAHFYHHHNAHHHSHHNHPPSCSVRSLSLTRLDLASQVNDFNDDNDDDGDDDVTAAAAADADANARFEYSDDIKTNGSTVSNLRHRIGSIFNYDNNITTKPKIQRSIQKPFCLYGSGFRVGSTSDDSSPKQEKIFHSRKTTFGSRNDLQFNLDQSINQFLLQSKHRRAYTVDHISRWIFPLSFTILNIVYWAYYLNVCNECSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXB6</accession>
    <name>A0A922HXB6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXB6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="105" mass="12207" checksum="4A14C5079D49C4F7" modified="2023-02-22" version="1">MAIKYKISAIGSTSSRQNTLRIAQEFKSKAVYRWHDYNIYKMKVMIVPVVITWDGLVTKIRPKTQYMTWLDHNRFSWNSILATILTSAMVSTDDIDQMMEAIGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXX5</accession>
    <name>A0A922HXX5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HFM1</name>
        <name evidence="14" type="ORF">DERF_009941</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXX5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="53"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="300"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="897"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9511483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1183" mass="137042" checksum="BBA6B82BB0A14D04" modified="2023-02-22" version="1">MCDNSVLIQSANDNEQSLSTVQAKFVAELPEPYRDVFSPRFQRFNKIQSNLLDLIIKTDKSLVICSPTASGKTVLLELTIISELIRLESSNRSHPPYDQLHALYLAPLKAIVEEKCQEWQQRFAKFGLKCFAMTGDTDIVDYQKYLKEQKQQVNILLATPEKFDSIIRTHSESRSLLRLLNLIMIDEIHMLGDRNRGDFLEATITRLKFIRDNNNHIIKVLGELDGDRSKERQRLRFVAISATSPNVEDLSIWLDPRNSLGIRVPADWRPVKLNKLVIGIEPTGAAQTSDYRFDIQITYKLERLIREHSESKPTLVFCSTRRSAEFTAKILATSQNTYFESRQQHIKLFMELSRINENATNIDTLIISKMEFEHFKNTELKTTLAAGVAFYHSGMDPSDRRLLEHLFSMSLIPVLVSTSSLAMGVNLPAHLVVIKNTVQYEAGSQTEYHLSQILQMIGRAGRPQFDTSATAIIVTKQEKKEKYETLLGEETDVESNLFRSLIEHLMIEIVLKTVNNINLAIDWIYSTFLFIRIVQNPQYYRSSIAKGDYDGARPIILEWCQEQMQRLQTLGLITIKGDFFDPTQLARIVTRYSVSIATLEHLIKWSKISYSLEQLLEEMCCCTELSQDVILRTTDKRFLNELNKKNRFKYKDRFRNGSMKTNCLAQAAFESLTIEQCLFDDLQRIIRSGQRVSKCFMEILVYFFRQKPETKTDQQPHWLHFQTSISAARLLQAFWTRLWYDSSYVSRQLPKIGLAFSTILAENGYTSFNRLLESNPRQIEFHLKRKPPFGSMLIEEIKNLPRYQLALTRQSNCSLKFSPFLEDHIESRMQIEFKCLIQQQSLSSSNILKPDKHYFHLIIGCEECDQILAINRLNDRTLMQSTHKQSIILIKTKFDDENESTDQIENEIRKIQQIEEECKNSIGNNIVHCSLRKTSSHTIIAHIISENFAGLDSETKSTIRYPFQQMDLLSTQEFDLLDSFDDDEYEEILAQHNIGKERKQDDSLSTLDSIDINDIQSTSLDGMTESSTSIITTTKKKMPIFNIKIDDVIHDQIEQNIIDENHDEDNDDDESLNYSIFTRFRNRNHSNTENELQKFVSSNLPETKTTTSINNNRKNQSIMNETKVAKIFPVKRKVCLQNPFDYNCKTSMAKLGRFNFNNDDKCEEKVSKYFLTITNNNDNYENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYF6</accession>
    <name>A0A922HYF6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase cytochrome b560 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_007132</name>
        <name evidence="9" type="ORF">HUG17_1597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYF6"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7646059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9516393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="168" mass="18674" checksum="080AE571AFF0EFF4" modified="2023-02-22" version="1">MLITRIITLYSRGQSKNIAAKIGQQIRNDSTFTKEAEKFMAKHAKRGSPQSPYMLGLTYKIQLTSMLSLTHRITGVGLGLIIYGFGIAELLYSNKNYSQLLDSYSSAIPCTSIFKVMCGTALAYHTFNGIRHLCWDMGYGYSLPRLYLTGYAVLGLTALCMVAMMAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYP0</accession>
    <name>A0A922HYP0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYP0"/>
    <dbReference type="OrthoDB" id="10457764at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="123" mass="14581" checksum="5CE784C0A16B3D81" modified="2023-02-22" version="1">MFIFRITTDGYGMAHQMIRVRRDDNIEQLLDIYIDGPPPLSRNWLVIIPNSLILDRPENWHNIRDMVQQLPLYPLVQQELNSIARRIIVVEEIPAAIQHWYRLHGNSPRYGNFRITSSYVRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYR7</accession>
    <name>A0A922HYR7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_010168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NALF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYR7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015275">
        <property type="term" value="F:stretch-activated, monoatomic cation-selective, calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055288">
        <property type="entry name" value="NALCN_aux_factor_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15819:SF11">
        <property type="entry name" value="MID1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15819">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN FAM155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036791484" evidence="8">
        <location>
            <begin position="22"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="603"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="726"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="731"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="743"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9511729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="922" mass="104699" checksum="F60A262AB68FFCCD" modified="2023-02-22" version="1">MNEFWFYWSSMLIIIIEPIKSTTVVSNGNDLIQTNEWPLRFHHSPWLHKEFIVRDQSKINDQYQENVDDFDVDLDTNIYYDTDQYHHHHHPQQQQHDQYYTRDDQKEKIDTCDDPDGDGCNRCFQPSIHCERKLKLKKQLLAEHIPGASLTVDELMSISRVETMTKEENRKTMTFQRCLYLNESLIDEMCHTDRRTMRKDLLENLHLRSCRRFLVERSLSKHLYSLVINSTDCSRILKELLVLDNLVEDLACEYESILHRYDCQAKWSVVWTCRDCKLAYRDWLCSVIIPYHLNGNLIKPCQSVCEQVQQKCPHLHPYGKGQYAGEPVFLCIDPNIPFNKKITPNIPFGDEGQCYNPCDLEPCFNDENEAPVLDCPHAKLSTRLLSTDNDDDLEFIDQFNETSILDYSAEQFNTDDSLLSLDMDMIDNNDDIIDDNNNNLDGQQTTEFSILPTTPSEEIDLGENFFDDDKMIIMTGNSDSQTMKSATTTTMTTKATTILPNDGQQWIDEDDYILTSIQHDEPLSSSSKSSKSKSINNQLTQSFQFIDVEQQAAAAASIIAAEMIGHFHSSSSSSSSPSQNVPEKSSEIVQNHDKQIQFENQKKINLPSQSTLENQQSPKQQEEEQQQEVQTLPPPSSSSSSSSSNLMDKTIELSITTNPSTIDPQTYVQEMYREALSISTTNDPFDSVGSNGGGVGLNEQQLNDELNIVVKDFLESNIVKLIDDGNEHWSKSSSTSKMTAIPTTESSTTTTTTTTTSSSSSIISETLPPTGTESSVDNNDVHQQHSKQQQQQSSDTNQIQMMNGSRKNGETNSGNRLYRHYNSRNKDKNSKPDNIPDKIQIKDQKQIGKNSQRSPRAAAAAAAIERNSGSSLLYITSHSNKAIVSNMVPNKSPNAVKYVRKANIFCPSNRLTRLDNFLRESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYU6</accession>
    <name>A0A922HYU6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">LIM/homeobox protein Lhx8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LHX8</name>
        <name evidence="15" type="ORF">DERF_010207</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYU6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF127">
        <property type="entry name" value="LIM_HOMEOBOX PROTEIN AWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 10" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="13">
        <location>
            <begin position="547"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="914"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="916"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="427"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="481"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="654"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="716"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="763"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="830"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="970"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1203"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="730"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="766"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="794"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="834"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="846"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="987"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1016"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1206"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9511774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1237" mass="137581" checksum="FEC38C5E0E02747D" modified="2023-02-22" version="1">MNREKLTKKSSIFVDRIVEFHCNHHHHHCHQKSDGLKKFKLMINNNHHIIKNKSHNCHHQRTYNHSLKNKKIINHNINNIVVKNLSRKRYNNNRSRVGGGGGGDDGVSDDVFVASDDGVGHRSVTNNHHENKLNDEIFSAFNHHHHSLKIPKKFHRHSTISMFVDDNDDGHHKDEFLKNFNKYPKTTMTLTNHEPSSSLMDINGPILETPQHSHNHHHHPHHHHHQQQQQQQHQSLNFNNHSTDVADVNHFIANNSSNHQQQQYTPAIHYPGGNDLIAATPMSSSYYHHNVLYGSIQPHHHQQQQLQPHTLSPLLPIADDVDMFDHHHHHHNRHTELLSNHHQQQQSISISLNEQQSSKYNDNHHHNQTNNMIGSPMVSTSGELIHSQNFNHHNHHHHHHQNHIHHQQQQQSTVMTITPPPSVLATDMINNGIGNGGGGGGVLPSSPPPSSSSSSTTSTLLRTTTTTTTATMMKNSSTLLLSTSSSYSPSTTIDTSPIGNNNNNNHHHHHHHHNTTFMNGTIINSTIGMMNDSTSTTATPTTTFDKMICFGCHQTLSTSPIIASVSGYHNWHIHCLCCSQCGQSLSQSRSCYIRNGRIYCKDDYCKLMIKCSKCDRTISANDWVRRAGMFVYHLACFACDLCQRQLSTGEKFTLEKQQQQQQQSSSSSSLLSPPNSNSSTTISMGNQQHHHMVIVLYVNFILVSKKVDESSSIVNQTQMDDDNNDDDDHHHHRHQHQQRQHRQNHRGSLITIETQSTQPISNVNLSQQQQQQQHQQQSQQQQSQSINSSSPSSINGNTLMIDNNSNKCTNNNGPAIINDSIIVTTEATTPKNTTNHHHQHQHQRHQQQTLTTLTTSESLDLNTTNNNNNKNGNVQQHNQSTPPSSSSSSSNIHSNSSLSSSSSSNNNNNNNSNSKTKRVRTTFTEDQLSVLQANFQLDSNPDGQDLERIATLTGLSKRVTQVWFQNSRARQKKFMNKSTSSTSSTHHYSHSHHHHHHTSVPSPTLSHSQHHHSHPVIQTANTSHQQEQQSLSRHVTTFDSSISGPTQSLLMNGQQPQQSTSIRSDGNGLWSPGTATTTSSTSSQNGMIGISNDTLSSSGHHGSIADLILGVSSTSSSSLSLSSTTTTTTTTTTTTVDGSKITLWGHSTSTATTKMTTSTPTPPLPPPLPLPMITNGNSIITTASQSLQVKMNNHNSNLCHSELLEQSSSNSTSSSSSSSSPQPQTSVTPNHGSNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZK0</accession>
    <name>A0A922HZK0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TATA-binding protein (TBP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tbp1</name>
        <name evidence="8" type="ORF">DERF_006699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZK0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000005">
        <property type="entry name" value="TATA box-binding protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9515927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="255" mass="29428" checksum="CADDA33E7C74C9EA" modified="2023-02-22" version="1">MCLYFVFNFSKKMDSEFDDCLPDESLITTDFNHIINDDNDEHSFDNQKIDDDGNNQSNELNQPPVQPPQSMINIRLDIDEPVVHNIVATANFNCRLELSKIVTRVRNAEYNPKRFCAVIMRIFEPRTTAMLFASGKIVVTGAKNERLACLACRKYGRIVQKLGYDVKFSEFKVQNIVSTVDMKFPIRLDKLAIYHGQFCTYDPDFFPALIYRMVRPRTVLLIFVSGKLIITGARSRTEMMETMEHIGPVLCSYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZR4</accession>
    <name>A0A922HZR4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribosomal biogenesis protein las1l</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">LAS1L</name>
        <name evidence="1" type="ORF">DERF_007121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZR4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="531" mass="62564" checksum="AA28B9D526C63687" modified="2023-02-22" version="1">MDDSVILLENEDSLPSRSSVNKCLQSFNVQRIRKRKHEDNTSGKSNKKLATMKQLDYQFTPWSQIEELIMARYFIYDSLYLGNTSDYSSEMEFNQSSQIFNRKFNLDAKPENIISEHLHLAHGCICDWIQRCTNLPNRSVQFIMQHLKSIECMVNILLEEFKLEIIQNNVENSNFSILYNLYSIGVINFCNVLSSYSDEIYSIRFLAKNLKCPLWIVQCRHDLAHACSNPPSLKTLKNAITFGLRWMDEYFWSANIHNEMQFRSIGPFPVLDYSPPQHLIYQNMERQKIYHNCWNVVLSPDCTGKRAANILKPIERYMNHDPNSFIGIVVQILISDVSRVSNQIIDLNSFRPLLLRRCSRLFHIVFAYEPEHMLLLLLNLIIDTVTDLQKSENIQLDSSLSIQIGCLWLEQIFKMIVMPLEKKQTSFEKSFLLLPDSKRLLHENQFAWYRLFHKLVKLDPNPILIRVTRIFYEQFLCDDRNIFLISWQKYQQILKLMKISIEIVSKKRLITPPLIRKNPNWNRVFIGACLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZS7</accession>
    <name>A0A922HZS7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZS7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="60" mass="6706" checksum="F825C5CFDE32EFD2" modified="2023-02-22" version="1">MIISSQQPICEFKAQKLSIINAEVALVPPLNQKLSVTMYNDNLLIDKKNGNYNVANESIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0W8</accession>
    <name>A0A922I0W8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0W8"/>
    <dbReference type="OrthoDB" id="6507399at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="197" mass="23572" checksum="C8C701AF01056B67" modified="2023-02-22" version="1">MSRILKTLIYIRDRMTFWAIKTTNEKYDDDDDDDNNDDEDDEAINLDEIEFEGRGMRTERILRAIIRVPIRWFHLNYHARKLERTMNKEHPECPVRVRIVDRLVGNNFIENIFDTGLMVIPCLFLFSFFLWALSQFVARTILEPVSYAIAFISVFIFFIFGIVFVFAAFFGYEFEYIDGKKHPRRKRNPPESYQKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1D5</accession>
    <name>A0A922I1D5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_007913</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1D5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038:SF3">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 20 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="578"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="864"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="167"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="8">
        <location>
            <begin position="780"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="443"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="687"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9517230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1018" mass="117272" checksum="4C061815B0334853" modified="2023-02-22" version="1">MNDNKKFTGFIDQPSSILSSPPTETLHHHQFDESKILQPPMKIFRSTSISISNNNNNDYLQYQQQQQQQQQQQQQKQHRSQLPQLFSGKSWAFERERNSYNYYRSEYPNDHNNHDDGGSEELEEQDEQERLASLEALRYALHHAPFCRNMHTLMSVPNEECFEMIGIPTKCAIRIESFSYENILDNINLEIPKGKIYALLGSANNGKSLLLKCILGRIPVYNSQAIEVFGQRPSLSPLSAICVGYMPQQIALHPELTIKQTLLYYGRLYQLPPSIICQRIQMLNNFFIETNHKNHHHHYSSSSSIQTSVHTLVRDLDQGNLWRLSLMVAIIHSPPLLLLDEPTDNVDPFVRSTVWSYLEKLSEKDGMTIVFTTKHPEELCYAYKAGLMRDGHVYIEDRPEELLRNYHCHTYIQMYNKFCMSNIPRRLRPSIAYYEQTNNDGQGFSGNLTIPPPSQLSYQTTQSQSLGEADNSSHNSNNFHDINHQQQQEQHFDGSGSDITATVANSVDNNKDKNTIHSYDGDDSNYSGDSMDVEDLQRTSLPLPMAQWPIAERRRTAYISHLFNFDFKRLYSLVLKNYFVIIGNIHLIILFYFIFPAMQIILVCFLSSRPFTSINNLPVTIVIAQSHDVNNPRIERLIRYTIDRSIFKPEIIVGDINESIKRIRRGETLAVIVPWLIEQTVIDFKNSSQNNDRTRDENSGGNNYNHDNDDEEEEDNFTYCQKLIYNWRMGFNSTMFGLRLHLDGSNFFINYLINFTLADSMQQLLTNDERMHELMPFDCPQIYHSMKQNHIPISLDIPNFLSRSSPPTNEKNLRLRFIEFILPGTILAIVFAYALVLTSYLFIKEQMAGLQERCLTAGASGIEILISHMISQSVLFFLQELLLIFLMKNMFGIPQRSIRWYGPGSLIWMLGFMGIVAGLFVGVICPRPRSAAFFISGIFMPGFILSGIIWPVESLPRFFYYISLSLPLTQPINSLRSIIFRGLDFRIGKITAGYTISSIYIVILVLSTLIIFKIKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1L9</accession>
    <name>A0A922I1L9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">XKR6_2</name>
        <name evidence="9" type="ORF">DERF_007145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1L9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF10">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="724"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9516406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="816" mass="92661" checksum="DD9B16BB034C3BD6" modified="2023-02-22" version="1">MRLQQQHFTPRTTTVSQQQPPPLSNTSPYVNSSSSLLLKKNNVVELDSSYSTNGSSKSTSSTSAIIIQPNAASSSTSQPDSSSLFLVTGSGEQTARKITSHSNQQEKFSKHPMNSTAISTLQRFQQQQQQLIGTPTGSNRRTTMYRLSSFNESSSSSSPPPPLPTLSSSTNNGGVTNELPLMTPTYESIDVHNLIDSHHSTFHDPTTTSATIAASAAVYVDSSQGTSDGGHEESNGCMSDNPTVTVPDNHRLYPGANGSQHHYYSRTASSIMPMSGIMTPLAFTHHHHHNHNHHYPLASTGGGYLTRSSHYYYHHPDYYYYGSQTNASNTSPPLLYGRDIDGSGSSSLRPLSSFNKDEDFDIFNAIFALISLMSHCCCSGSTFILAYFLWRHEQDMLLFWLTIFATVVPSIIVNVISLKWLLNDNHRQQHEKYHQQQNNNNNNNSNGTTAEPFLLRRPEIGPCGWMFRILLHIILLGPVLRYIELLRYGVKSWSDKRRRVDYQQQNGQKDGGWSTSSSTALPSLSTTLPRPRFQSSIGPGGLPDFEPARKSASHEKSSFNRIDYYLLTVAEDRDTSLLSLFQCLMQCTIQMTLHLHSLISHWYFEHHHHLNNYNHNYTEYVQMTVIFLALFETSWSISSYHRALRRASYDKRNLSAFGTIIQSFWHGLTLASRLLAISLFLHQFGYWLLPIGIGHWGIMTIWIMHQGTHFFDSELGRPNPCQEYMFNMLIGLIYLFIFINLKDEPTRYKYFAFYTVIMVEDFTFAALWFLRIETDYFWSLRSLLFDCRTNIIHCKHSSHAILLLVRTSKWTSIDCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1R7</accession>
    <name>A0A922I1R7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitogen-activated protein kinase kinase kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_007752</name>
        <name evidence="3" type="ORF">HUG17_2082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1R7"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF304">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 13-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="243"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="829"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7646544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9517052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1009" mass="114302" checksum="907DAD1A339A6C7A" modified="2023-02-22" version="1">MSTLKRTLKRGGRDRNNIGSSVLPDDDVQGIFRQLESPHFLNYDEKNQQQSLSTSPKLSPTKETSIIHNYNNGDSPRCDGDTDHSHHHHHQLILDVTQAPVSYSKNSIDHQQRLDSNNDSYNQQDSSGNDRPFIRAHLFRRSFSLDDIVQYQNRISCEHHDHENIDPNMMIDHYGQPYIHHNQSTMDVHLHHIRHSQNPHGKISHHQNWLGGVFGCFKPIIGIISSKGFKDGKHNCEIPYENLKDMQFLGSGAQGSVYVATLNQELVAVKKMRDKCETEIKHLRKLNHKNIVAFKGVCTQSANYCIVMEFCPYGQLYEYLKKCEFMPPAQVIDWSHQIASGMNYLHQHKIIHRDLKSPNVLISHNSVLKISDFGTSRQLSDCSKIMSFAGTVAWMAPEVIRSELCSEKVDIWSFGVVMWELLTLEIPYRDFEQSSIIYGVGNANLSLPLPESFPKGYRLLMQMSWKNKPRNRPSFQQIIAHIEIASREFSDFKLEEFCDKQRQWKEEVRHALSQTRINFNNQHSLSSSSQVAGSPVSQCSDHLRSKNKKKSLNHLDQLDPTAHLDLDEPLQSALQSAMIRKTASLYTDMVKVIESLVERERKLCESENGGSQNGAEFSESARLPRKPLTEKLLEKALNDPIYKSALELSRESSKVTNNDLCDSLFVRALESPIRQRGGSQYGSVKAKLRRRNRRLNQCYSSSSKDISFSMADSQDTTAQEPSIALDDCNDLIAVQIDTANKPNEQDLSITNQSNNQVPMIRGVPQRRTFDSGYGEGQSCVSSPIAEPKKNGYNGNGGNISASSANTSASLSGQRMRARLRRQKAIDRGSCPSSAQSSSRSRPMSSSYHQQLYTANSSTDYEDNDYDDDRSLYSRRSSSVGRIQEFSCHAYGRLRRKTSTTSSSDNNDDDDEDIDDEGNTSSSGNEENDREKAHNIAIIKRKLKASLPPPGRRSATERRPYSGGHHHHHHHHHHHHATSNNKYLTSTVKQQHTMTTLNDKVGDLSPKIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1V2</accession>
    <name>A0A922I1V2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1V2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="129" mass="14548" checksum="4CDD6EC1052E194D" modified="2023-02-22" version="1">MPKEQQTTEQENTIIKGCQTDLAPTSNSCVQMYMMPGNLYRSSTNMSHRLSPVTANSARIWPNLEYQTIKNVAVASDINYRFTGDIHHDQFIDSTYGHCPGIDHNATLRAHHAQQRMADLRDSAKPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I292</accession>
    <name>A0A922I292_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3">5.1.99.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">APOA1BP</name>
        <name evidence="11" type="ORF">DERF_008731</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I292"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="10">
        <location>
            <begin position="47"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9518134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="297" mass="33352" checksum="3CD9FAFF354B5048" modified="2023-02-22" version="1">MKMKFLRRIDQKFVWSCHSNSTTDMLMKRFLFNDSICRIKFLSQTEAINFDQELFNEYQFSVDQLMELAGLSVASAIYKSGSLDPIYKPPGQILVVCGPGNNGGDGLVAARHLKLFVSNQTAELNGCTGYNPVIIYPKQGKGQLFVNLVNQCKRMDIEFIDNVDKLDSYKLIVDALFGFSFKPPLRAESRPILENLSRIDHQNKRLISIDIPSGWHVEHGPSSSSSSENDTNGQSLTPIIKPDCLISLTAPKKCAQHFRGSLHWLGGRFVPQSLAQKYQLNLPEYSDAEQCLLLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2D0</accession>
    <name>A0A922I2D0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">UBE2E3</name>
        <name evidence="10" type="ORF">DERF_006915</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2D0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23793">
        <property type="entry name" value="UBCc_UBE2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000003">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="102"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9516155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="249" mass="27204" checksum="DD96B4FCA244F1E3" modified="2023-02-22" version="1">MSDDRIDPYSQQQQQSQRYKRQRTASATETSSSSSSNSNQELRAGSAAVLTTPSASTSSGSRTTRTTMATNNHHHHHSTTSTSSSSTNDNAATASNKQNGDSTKDGNSNKTKPLTKALSTSAKSAGPKGDNLYEWVSTILGPPGSVYEGGVFFLDIHFSSEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGNIATQYINHREEHDRIARLWTKRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2I2</accession>
    <name>A0A922I2I2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2I2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="102" mass="11046" checksum="DE57EB35BE2AE359" modified="2023-02-22" version="1">MICVTKVPGQLGMKIVDTISGTAINRSSYALLSLLLLADESLELVVDLSFFIIVDLFLPPPPPPLGPTPCCSNALARLFKLTLLRPSCICNRLNFIAVRYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2K2</accession>
    <name>A0A922I2K2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_008889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2K2"/>
    <dbReference type="OrthoDB" id="6356248at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF4">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="938"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1008"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1170"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="964"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1171"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9518299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1189" mass="136363" checksum="B36AE34F5919CE29" modified="2023-02-22" version="1">MIHHRHQQVCFGYDDDIHSITSNRHDLANSDEMIQNSRQYSASTADLFISQNYPANIEDGIIIENINQNTNSYQHNQSVANMVVTKDSKRLARIFLDTSQFDQQQQLQHSTEIMNNGFDCNANIYTEPTVVNTTLTNQRPPPPIPSNFSESHPSMNHAMNNSGTDSLTIVGQDIAITLRQGQLTQTLLTNSTTSPLVNSNTVNEILPTNPRQQSHVLKQQQQVVFYPNRMEFLPLCDLLFNIISLAAYFCDVVFDSVTAYTLYLNRQFTWLGVSLFLILMTAIISHILSYRWCRRDVDEQYGNNDQKQNQRCSSANPIMLHPDRWKDNSSQIMTFIHLLQCGVLWRYFKLFAPVNLATVKREVSELCILRMVHAFFQAGPMLLLQTYLVWRKPSLNMITDLNIISIFLSLFSICWALSSFNKNIRPDKIHRLVLTWFGVIFQFFWRVGTITSRIVALTVYAVLYEQWVFVVIFLHWFSMLLWLLTPHMLQHLDHQVDGTNNQKCNRKKKLLGAASLAWIYVFCFVNMEDNHSRYRMLAFYLMMFAENILLLSISMFFDNRLSTIHGYRSLAICLVIGSFIFGIIFMCIYYRYFHIRNLKNSIQCSTAPSGATIDFENCPSSQPDQISMKEKSLLDQLIMNQTQTLAINHKDMDPKLLPFAMNTIPFLNHQSQSLRNNLNQMNVDGNSTTINDKNIAGVFNCRLNPALKRKKKKPSTIPPLPQEMLINGIDAGDRSTNKLPLKNTLESISENGAMNKSSSQIQRPALDSWKPGFHSKNFIKQIQRPLTNSSVLMRSYRQSPAETCWRKPDLSGRSWSISPAAMMKIGESSKFGSSVIQTKDSVSFQQQPTAKFTDKLDFALMNQLKFESNEMMNSKKIVRPKPIVQHSINIDSISEMNIDINHTANLQTSNYGNFSNDKQHQEVIYNYYEYLNSLKSSKKDLSGSSDNNPDMFNMLHQRPPVPGRESRNKMKEDQGGHQSANNYEEGKKSLINNYTGKNQAFKTTILTSSLKQQPQHHRHSTRKKRFHQGAKNSKNRIKSNQKYRPRSTNLSTTSYSSSEFSSKSDFSSGEDGDIESDVNHHTDVQQKYNGINRTKLHLPSTLTNQNAYLTNLYDQVNQDYDNVIATDDLHNVQSECQAHLDSGYGQIAATNFNELNFVSSTVNKYSPYFHHSNSIRPQQQTAKKHNTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I306</accession>
    <name>A0A922I306_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I306"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7351" checksum="33F61B241C79092D" modified="2023-02-22" version="1">MIEVLQSSSLEFKLIYGLQLNEIIQIGCEVQARPTADVSFQWRFEKHTNLANFIVINETNSEHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I311</accession>
    <name>A0A922I311_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_007808</name>
        <name evidence="11" type="ORF">HUG17_2128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I311"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="10">
        <location>
            <begin position="55"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7646590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9517111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="352" mass="39965" checksum="FA14FC8DAA68182D" modified="2023-02-22" version="1">MSWFSALRSNGQQTTSARQHYEDEQYQEEIVAQFYLPYPKLECECSDYHDDIRLSAGVASVQGWRVNQEDAHICDLEFDSDNQLALFAIFDGHNGPEIARYAAKQLPQLIKNNSCYKKKDYGKALEEVFMQFDSSLLNNSVNNELIKISHQHELCYGRIKRRQTSPLLAMVTGSTAVVALLCKQNGQLHVANIGDSRCVIYVKNKTRPMTLDHKPTDMKELKRIEMAGSRVINGRINSGLNLSRAFGDYMLKANGSLGQKEQALIAWPDITVSNEKIRHNDFIVLACDGIWNSMNEKEACSVVRKYIKRNMKPSKICQEMIRRCISPVRPIDGQNGGDNMTCIVVKFEKDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3T4</accession>
    <name>A0A922I3T4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002711</name>
        <name evidence="1" type="ORF">DERF_004687</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3T4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="7141" checksum="A085CEA80FE46BF4" modified="2023-02-22" version="1">MEIHGYIEKNVKSLHVFILREQETQTLLTWAIHKRRIKRQTFWERTIYSLTLNVDALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I442</accession>
    <name>A0A922I442_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PRKAA1_1</name>
        <name evidence="14" type="ORF">DERF_004833</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I442"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043050">
        <property type="term" value="P:nematode pharyngeal pumping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14336">
        <property type="entry name" value="UBA_AID_AMPKalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000079">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000055">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000136">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049020">
        <property type="entry name" value="PRKAA1/2_AID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21147">
        <property type="entry name" value="AMPK_alpha_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="31"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9521162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="568" mass="64514" checksum="CCEC2097E345AC0D" modified="2023-02-22" version="1">MADKNSQPQPTAAMAINNPQPHSQSVKIGHYILGETLGIGSFGKVKIATHQITDHKVAVKILNRQKIKNLDVVGKIRREIQYLKLFRHPHIIKLYQVISTPTDIFMIMEYVSGRELFDYILKHGKLKESEARRFFQQIISGVDYCHRHMVVHRDLKPENLLLDQNLNVKIADFGLSNMMRDGEFLRTSCGSPNYAAPEVIAGKLYAGPEVDIWSCGVILYALLCGTLPFDDEHMPTLFRKIKCTYQIIYLIFYLIFNPGQFLIPDYLNKSVVTLLCQMIQVDPIKRATIEDIKVHEWFKKDLAAYLFPSPTANDASFIDIEAVNEVCEKFGVTEQEVHDSLLSGDAHDQLAIAYHLIVDNKGIEDEAIKLDLKDLYVSSSPPPYLDSSSPFPKQRQRILSGGGVSGAGVNVSAITSDNRQRTNSVGQQDQKNHKTTPIKKAKWHLGIRSQSKPIDIMNEVYRAMKLLEFEWKVVNQFYVRARRKNPANGKYFKMALQLYQVDYKSFLLDFKSLPDDDEEDKDSVITGPSSLTGNMASTTEFTGHAQYKNHNIMEFFEMCASLIAQLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4W8</accession>
    <name>A0A922I4W8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">XPO4</name>
        <name evidence="9" type="ORF">DERF_008091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4W8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9517415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1152" mass="134059" checksum="B2C509C9C08C7573" modified="2023-02-22" version="1">MSTSEILQQLETCAQILMAPPNNIGLNDRTKAEEVFLNFQKTKTPFTLCREIMEMTQNQFVLFQVGACLKCAIIREWSLLGVEQSSALFNYLFDYVNRRPLDQYVVEEMMLVNAIILKRIDLEEKRTNNAESSKDQNETSKTMIASLFVIIKNPAAAVQMRINACTAIIRILSEYSTLSYNSDYGLSWHSHLNVKRSFEKLKLKEIFSGAIEVLYGQIKMAEETRRSNDNIKLSAKLIRICEMVLTWNMESFSLITGYFVKARDRIESQVFNPPSDWLKFIIEGNLISFFFEMYLSFRSIDPNLLHSSLTCLTQLSTMVSIRHDMTLRVKFSETFMQNTISLCNMIMDVISLHEVQFLSNLFNSICIYLRSHVVIDDCNPTLTKQFIDVMIKFTCKVLLESVKIKTHFDEDDFDKCNQSIEYLMNSVMIIVNLNHYDRRMQQEIQGPNISGDQNGQITLQELCSWTKPLFETYLRVHLSEPEGLLPLSCFKDDDEIQEFEEDDINKFREQMVAIGSIAQVDLRSSIDTITQLMIMKLQQFEACITAMDMKVEDKTLQWIRISEDIHWILMISTYIFTSFAESEIPTEVIELSIKASADIQTTMGALQNGDFTRPNIDPIVRYFIVILKLVQMEKQLLENHMIQWVSPQVSYTLTYFLSRTLNIYLVPPEYESDHSQMSLTLNSCFGADSQNVKNLINFFLDHMETKFLTMSSETQVLELSSEGLRLFCKFRDRIKLLNECASLQRLLQRFPVDPNFRKLNSAVRRNMYNVFIVVFAGHPDAVIDPLIHLYQTFRQHLRAGQRELIQEEFLNIVDFTMGISSGTTSYTYNVIWQKFLRPFYNELPEVLKVMHKCSIVVQAILELLFHLSSCFCIYFSEEDNLVFYKTAVAIFTQYASYTKDTYSLDATRLEEIQAEFIWILKFLNDLSNQDIFLFFTNPSMTSSLNQTIGQVVITSLNIIMPLMNDQLLENQQLCALYYKLLEFISQDTDRFKGFPIKLFESYLKCVEYAFRANNISNEIKAIGFKILVQLGYQTAASPEPSEEIMKFLRPFFQIIVEFIFCELVRNNDLILRDAVAMALYSLVRCFRQSYQNIIRELMRCINDPPIEDRICTTLFTIIEEVGLDSRYNAARLTFKKQFSEFINQLHTMLTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I539</accession>
    <name>A0A922I539_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I539"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7152" checksum="A1C2D837B585F681" modified="2023-02-22" version="1">MMMIKGADGRIEKEQLLKSQTEAEEFCKSKVTGYHHTTDAQQDHHRLPDYTHQGYDADDAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5H9</accession>
    <name>A0A922I5H9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5H9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="94" mass="10223" checksum="EA5F6CAFCBDC183C" modified="2023-02-22" version="1">MKTKKLNKNKMSSPTSPSTTSTSTTIRRTYSNSSANSGSINFFDTVNEETDDDDDDDDADNGNKTSTTTTTTTKINMDDSSDPINIVKALEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6D8</accession>
    <name>A0A922I6D8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6D8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="6760" checksum="2B67A98A058E3714" modified="2023-02-22" version="1">MFLSPSPSNAAPKSYGPLRILSTRSAAYVRFGSGWWPPKSGRGSQRMAASALAPSSCTMIRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6R0</accession>
    <name>A0A922I6R0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6R0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="179" mass="19439" checksum="CEEA8338558EFB69" modified="2023-02-22" version="1">MINLDCGTVLTSPTAMNETTTYPTLRMTNSLPLTISNVGDGLSSSSSSSATSSSSSSALFNHSSSSSSSSKPLSSAITTITKNVCTQQQSNNYGNIHKKFNIINKNDVNCNQKTKTFVTENVQTNNNILNNHNDDNGKKLTTVVGCNEFPLNHLKKFHCYHNNDNDNDDDDDDATFSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I711</accession>
    <name>A0A922I711_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="13">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MCM6</name>
        <name evidence="15" type="ORF">DERF_000276</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I711"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="333"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9526174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="806" mass="91217" checksum="76F16F8A049E6A3A" modified="2023-02-22" version="1">MDVSEHRTAQVSQVKDEFAEKVQKLFKSFLLEYVNESESNVSNVKPKYYDETLALIKPERNTLFVDYRDIINYNQNLANDLKTDFYRFYPYLCRALNFISVFYGIAERTKLRSLRAIKCSQLVKIVGQVVRTHSVHPELISGTFECMDCGTEIPNVEQQFKYTLPTICQNPMCNNRSKFRLLLHKSRFADFQKLRIQELQADLPRGSIPRSIDVIIRGGDRVECVQPGDRADFIGCLISVPDVAQLIAGSAGLIKSDSGATGDGVRGLKALGVREMTHKLAFMACSVILEGSELPIQLEERQKFESDHMEQNFVMFKENDLHRIEEMSQDKNLFNNLAKSVFPSIFGNDDIKKGIILQMFGGTPKITEENTNLRGDINICIVGDPSTAKSQFLKIVSNFAPTRAVYTSGKASTAAGLTAAVVRDDDGGFVIEAGALMLADQGICCIDEFDKMDIRDQVAIHEAMEQQTISITKAGVKATLNARASILAAANPINGTYDRAKSLRKNLSFSLPIMSRFDLFFVLLDECNETVDYAIADRIIDQHLQCSGNKPSNNDDTVYTLDEVRMYIKFAKQFKPKMILESEKYLVETYKHLRLNGCGETGGGVFKSNKQSWRITVRQLESLIRLSEAIARLHCSNIVEVKHIKEASRLLNKSIVRIDQPDISLLDDTTMSQSEQTDSNVVDSQSQNESISCLKISYEMYQTITNLLVIKLQREEARIEAGESEGFRKSQLIEWYLEQIENEIETQVELIQRKMICEKIIDKLITVDHILIELKSPVSQEMENEQEKVEPDNILVVHPDYVIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7A4</accession>
    <name>A0A922I7A4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7A4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037893577" evidence="1">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="84" mass="9233" checksum="C8275B4071EEE680" modified="2023-02-22" version="1">MGFYMFLTSVLNMEIFLININAHNYGACSNKYITPAGNKVVYRRFGTFKLGYVLCSSTATSDMTSSLADAISPQMGCVKLQSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7W7</accession>
    <name>A0A922I7W7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_003600</name>
        <name evidence="7" type="ORF">DERF_003984</name>
        <name evidence="4" type="ORF">DERF_004706</name>
        <name evidence="5" type="ORF">DERF_005173</name>
        <name evidence="3" type="ORF">DERF_014011</name>
        <name evidence="1" type="ORF">DERF_014272</name>
        <name evidence="2" type="ORF">DERF_014872</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9498087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7W7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9498087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9521028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9521522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9529733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9530160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="133" mass="14608" checksum="9E09A566171E919D" modified="2023-02-22" version="1">MKVKLRDFGRSSGSPTLFIGNQAKLERIRWYPKDGELCLGKTKPEETLVEVCSDSDVQIDRQTWDSRRFLTQSHPVKLMIRGLGVETTSTYSQTLNGRAAMIALKVSDVGLPGAVIGADLGGSSKYSSENLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7Y1</accession>
    <name>A0A922I7Y1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_000705</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7Y1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08554">
        <property type="entry name" value="Cyt_b561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF0">
        <property type="entry name" value="LD36721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="70"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9526639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="406" mass="45694" checksum="CBA9E960BF71C316" modified="2023-02-22" version="1">MQQQQSTSTTIPPSPTTTPTTTASDTKVKVERTTSRSGDPKEKIKISAKLNENELKKDSKSQMNCGLYFILQMLALVTLILMVIWFIENFGGLSFQTSNEDNSSSGGSNWDQFLNLHPIFMVFGLVYVLANSLLFLTSSQSLRFARILISLVIIIVGSIGLLITIYWHMNENYQHFDSLHSWLGLMTWIFLLTYLVYGFNVYVSNVNDDRRRVRMIRHLRMIGIATLLMAGATCLLGISQNLIVRSMNKPKTTIFAADDDQKQNQTSTTTMATTTSIEDGQLDDQLVFQANLIGNTIGMFLLCYILSMIYLMARMRYEPWSMRKREQIEKQLRATVEKAMAKLDDEDNNNAASRTSINNDGKSGKKGVRNSKSKTKTSKTSFSKTETTTTTKQASSLTPTTTTTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7Z1</accession>
    <name>A0A922I7Z1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBX domain-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">UBXN7</name>
        <name evidence="4" type="ORF">DERF_001108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7Z1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14345">
        <property type="entry name" value="UBA_UBXD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000079">
        <property type="entry name" value="UBX domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054109">
        <property type="entry name" value="UBA_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22566">
        <property type="entry name" value="UBA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="362"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9527062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="444" mass="50909" checksum="C8BA1C6C3A7113EE" modified="2023-02-22" version="1">MENQTEQDSLLTQFINITGADESIAKNALEACNWNVELAMDMFLDSNLAQTAAATTTTTSSSSSSAAAANNQSNNSSAANIITEEVRPPIPPVRQVLVEDYPRNMYASSSSGFDGFRNFQEESRWQEQQLNDEPEQSIDSSNRRRTFDDLFRPPLDLIYRGSFDMAKYEGQRSNKWLLVNIQNPKEFSCQVLNRDVWSNSAVKDIINEHFIFWQTYHDTQQGQNFISFYQVHQFPYISIIDPRTGEKIIFWHEIDTVTFCEKVTQFLNEHPSPTGKSQTSSSSSVVANNPSISYENFQKPSPYEESEREQIEAAIKASLQDMEVHNNDDDDDDDDCKIVKNDSMIEQQQPKQDDWRNYLGSDESNKMEIVIRYPNGNKEKVMFPSDSKLKALFLYVTEHGYNMNEYDLITNFPKKNLSSSYNDTATLENVGIHSRDTLYVQTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I851</accession>
    <name>A0A922I851_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_006005</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the paired homeobox family. Unc-4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I851"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000102">
        <property type="entry name" value="Aristaless related homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46799:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN UNC-4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="222"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="224"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="370"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="665"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="734"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="552"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="813"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9522435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="825" mass="89339" checksum="6B749CD117D024DC" modified="2023-02-22" version="1">MGMGVLPAPDFIDHHTRHHHHNNNHHHHHHQQQQQQQQQHNHQFNHHHNQLITKLNMINNHPFKQQHQQSQRDQLIASVSAFESAALAAAAAAAAAAVASSSTPSSPPLQSLQQNLNTSMNNGNIDQDDHHIDNDDCDDNNDDDDDDDDDDLMSIKVDEEDKDELFENEQTTTTQSTAAAMTHHRSLMPHTMSTRHLYDPNMHHRHHHHFNHHGHSDDFPKRKQRRYRTTFTSFQLEELEKAFARTHYPDVFTREELAMRVDLTEARVQVWFQNRRAKWRKQEKTTTTTTSTTSTIVGSINAGSNGGSIVQIFGNNNNNGSNNNIHSPSTHHQSLYHQTNIIAHPYSVGGGGANTSHIIPTSISSPLHGLSGSTSLNNSSSGGGSHSVSPLHLAPPSLPPLSHSSTNHTSTLVPPSVTSSSSSSSSSSSSTTTASLHTTNSDQSSLSMHSSPISASSSTSLHHQFFGSNTAAAAAAAAAALSAAYRKQAIANMLQQQPTTPTSSAALLEHSIKSCMSNYANNNSMLAPNPFGFPAANAFAMRELSLAYPHLFPPLPPPPPPPPQHPSSPAATSIQSPFGNISPFFTPYAATNSFQSLLATLSSSSSTSSNLPIKNKSLYDDVETKLSMQFPTTTMGTPGNPTLNPLLDLPTNSMAHTIDSLFHHHHHHHQNNQNHSSSSPTSSSIDNDNHTRSIKSPLINRNINDNGGSSSSSSVIIKSSKTTASSLMILTGSDDSQTDISEHSPNTPPPSTTTTTTKTNNDNDHHHHISSRSPSPLLCNNNNKNKKTLDETNQSSSNLKNDTNVSLMNSGKSSSSSSAATTATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I890</accession>
    <name>A0A922I890_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I890"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039679">
        <property type="entry name" value="NRBF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14964">
        <property type="entry name" value="NUCLEAR RECEPTOR BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14964:SF2">
        <property type="entry name" value="NUCLEAR RECEPTOR-BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140361">
        <property type="entry name" value="MIT domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="292" mass="33635" checksum="78A47E12EE8950A9" modified="2023-02-22" version="1">MNGKSFKSGKLNCENFHKFFNYNHPITPKKAHRSHRKAEYYSRCHQFSKAIFHYTKAIQYLEYSIQTTRCDNIRSSLTVQRSYCFNQIDHLERRLQSRLTNKLTNRKENLQTVLSNPNSSSSSSSLDQYSNRHRSKNRGDETATMANRITSESDDMDLCNMLKRQESLLEQLSFTLKNHNQSSQKSTPSSSPGSGCSFNSVKIDGQTPPISIVNELQTMNEKMKSIYLNMVETIEKSKQETKTLQKENQSLRKELNSIKNDPNKSKNVSNNRTSTISSFPELPPLEPPTLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8G3</accession>
    <name>A0A922I8G3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_000952</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8G3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="236"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9526894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="325" mass="37534" checksum="97D7A10C89C45AD0" modified="2023-02-22" version="1">MAYHYLKYYLPISKMEFNYHQQQQFDHFAASSSYGCYAEYGEYSYHHHHQPAHQPPAAAAEIQPIQFVCHENNLQFKQSLSNEYETYQSIPSLSPQSQSLSYTDSYYYPSSAEHSPYNESEESNSPFGQIDNLDSILNEIANAENIDDILLAKNEDDLYNLLETSEHECDSQIISVNSETSPKRKLSIDSSGYSSFEYDSETLSPSITTITTATTATSPETKEKKRRNRRCKHTKEERALRKKDQNKKAAIKYREKKKVETETIEQIVEQLEHKRDGLSIQFRKIETEFNVILPLAKAAFQMDPIRAPKLQQLLARLQQNGFTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I913</accession>
    <name>A0A922I913_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor ap-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_000519</name>
        <name evidence="8" type="ORF">HUG17_8307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bZIP family. Jun subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I913"/>
    <dbReference type="OrthoDB" id="2187714at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050946">
        <property type="entry name" value="AP-1_TF_bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462">
        <property type="entry name" value="JUN TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11462:SF35">
        <property type="entry name" value="TRANSCRIPTION FACTOR JRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="142"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7640838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9526423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="215" mass="24806" checksum="06108327CC1D1875" modified="2023-02-22" version="1">MSCNEDIRRLKNKLSLDFNQPRSSKKQKACQLTTPDLDKLALSTPQMAEYLKTIPTIGPLPTFTRNVNADDEEKQRMLEMWSNQAQMNFATTNNEIETNTSTATNIGSDHKSKNIKKESESTAGKNNAKNNKGFQPINMEDQEQAKLERKRLRNRIAASKCRQRKLERIHCLQKKVDEYNNKINALQRFETLLKDVNNQLSVQITKHRDLGCNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9M9</accession>
    <name>A0A922I9M9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9M9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="127" mass="13826" checksum="91660A180BA73725" modified="2023-02-22" version="1">MTSTTTFYHHHHHHPPTPSSSSSSSSRNYSSSSKYSAYSSSSSPSSSSSSSTSGSPSSNIKYNNLYSISPTTSLLSSSSSSSYQYKTRSSYDLNNYRPSSYLSSSYSSTYSPKSSYLASKFSGKYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9T8</accession>
    <name>A0A922I9T8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcyclin-binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_001618</name>
        <name evidence="5" type="ORF">HUG17_4714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9T8"/>
    <dbReference type="OrthoDB" id="164025at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052289">
        <property type="entry name" value="Calcyclin-binding_UBL-bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164:SF3">
        <property type="entry name" value="CALCYCLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164">
        <property type="entry name" value="CALICYLIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="68"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="3">
        <location>
            <begin position="143"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7641669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9527611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="220" mass="25377" checksum="06EB34777B54B90C" modified="2023-02-22" version="1">MASLNKLVQDLGEQIKELDRLKGEAQLDCNRQFIQNEINRLSLVKLNHEKELAKLTSNFGQSDQLGVIAVTNYMWDQSNEHIKIYIELDKTEKVDNGEIRLEFLSDTKFTCIFGKFRFTLGRLFKPLDQAKSKVIISKSNKLVITLYKAKSEHWSSLQSTTGTSPKLMDDKKDIDSGDPEKSLMNLMKKMYDEGDDEMKRTIAKSWYESQHKQGMPDFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9U2</accession>
    <name>A0A922I9U2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc ion binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">Hr96_2</name>
        <name evidence="12" type="ORF">DERF_000916</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9U2"/>
    <dbReference type="OrthoDB" id="6352325at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF283">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="387"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9526858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="624" mass="72966" checksum="72E757D71B502F79" modified="2023-02-22" version="1">MDFPLKNKICGVCGDKALGYNFNALTCESCKAFFRRNALRNKNFRCSTGGNCKMTARTRKNCRQCRLKKCFEIGMRKDWILTEHYKKLNIHRKHRRRHDIRPNSSEQQQPKTSTSDDGGSDDDEQSSPTNIIIIPLLMDNNNDSSMDCLVQNDDLIKFINKKCETKNHSTMGSSNIITDNGHEWPTNQCYNDHDVVGNMSMINDNKKDIFGTKNCNLNEIKYESKNEKNVKQVIGIVTNDNNNSSHSNSNDVLNDNNKQYCDGKKYFLMNDDQFECFENSNCLRNKNSTTTTTTAAYSINNDDDDDNNSNGHEMFDNLEKAAPIIELSSCSNYIWHISDFAYRHAIRLEHTLNPLDHQTSSVTNINPDDEQERQKQLFELNPLEQEKLDEVNHYLRTLYDLGDNPENKKIIRHVQDGLKYLEMSMKNLIITVKNIPPFKRMCQEDQIQLLKASAIDIKWIINLRFFDESRKSCLLPNPDAEDRHSFIVFDDDYLQQTYGEEMIARLRNLFISFRYDWRNDDSILNLLSMMILFYPERSNLIHRDYIAVQFQTYSHLLRKYLQVKYSSICEGRSIYLKLLTGIQEIRYLNEQFLDLMLKIDMKLIGPLTLELYDLNLSKKNKLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA40</accession>
    <name>A0A922IA40_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Complexed with cef1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CWC15</name>
        <name evidence="15" type="ORF">DERF_001044</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA40"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106018">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13210">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000135">
        <property type="entry name" value="Myotubularin related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="14">
        <location>
            <begin position="126"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="13">
        <location>
            <begin position="676"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="592"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="9">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="336"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9526993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="735" mass="85551" checksum="D118AAB1BB2D63C9" modified="2023-02-22" version="1">MEFIRTPKVENVRFLYRYPTVSNSSSTGTLYLTATHLIFVDPGLQRETWILHSLIASVEKLPITTIGSPLLMRCKHFLCITFVIPKEKEAHDIYQSLIQLSQPNRIEQLYCFHYTASNEFFTIDDGWNKISLEKEYERMGCPNNNWKLSTLNKNYELCKTYPQCLFLPSTADDYIIRGSARFRSKSRLPVLSYLYTNKASICRCAQPLSGFNARCIEDEKLLDHIRRTNPQSPLLYVVDTRPRINAMVNKAQGKGYENEMYYENIKFHFFGIENIHVMRGSLQKLIDACELRVPSMNSFLTGVEGSGWLRHVKSILETSVFIANAVHNGISIVIHCSDGWDRTAQTCSIASIILDPFYRTIDGFQTLIEKDWLAFGHKFTDRCGHFNGDNREMAPVFTQFLDVIWQIMQQHPCAFEFNERFLININDFVYNVQFGTFVRNCERERNESRLSKRTFSAWGYLDAHRIEYVNPLYQPMDSMLTISVAPQFIKFWRGLYNRFETGVHPRDFLEDILRAKYHHIDQMRKHITFLENYLAQKQQQQQQQQPKENGGEPQKFRPLGSIDLDEIDRPLKVVEQCMQRLVMQHEQNLKDQQQQCIDEDEKSKSSLDTNENRTVDNQSPIPRPNSLKLGNNNIQDDEHNETEEDCLSMPLEQVVQDCSIISLNWQSFQNLKNCSCSTPLEPYSTRLHCFACGHIFCVRCLGERCTIPCHQPIVSFKSVCRNCFKRITKSNSIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAG9</accession>
    <name>A0A922IAG9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAG9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037320016" evidence="2">
        <location>
            <begin position="25"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9527914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="220" mass="23770" checksum="171D0F5CC50C3682" modified="2023-02-22" version="1">MSTESFSLTLLMMASSMMMVIICASSSPSSSSSIGEDIEQQQPQLAGQQCAPSDIQCNEVSNPSTMMMTQRSNPSSIQLVEPSIFSMPSSLSLSQNPASALLVPTANIGSNNFGDGEQQSQQQSSMRIQEPIDLDWLMNRIPQQPHQTSFLLSGSSPITAPKLIRAFIVSNGKGDGSSSISSSLSSSQSVDRRVARTPLLNMANRFGKRDKLRMSNRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB79</accession>
    <name>A0A922IB79_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein TEX261</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_002245</name>
        <name evidence="8" type="ORF">HUG17_10211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB79"/>
    <dbReference type="OrthoDB" id="28257at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7636241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9528289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="199" mass="23128" checksum="B773C4AA67E84C9B" modified="2023-02-22" version="1">MWFFILLSWLGIVVLLLFFVLSLATGLYYLAELIEEYTTVSCKIIRQLNLFIIAIYVGLFLFENLPSYLIICGLLSHLNNMVILKTFPFFQLSSPSFIFFIVMLVINHYLAFTYFAQVNLYFVQVLSYFTVCLWIIPFAFFVSLSANDNVLPTSIENRNSDDHDLISHYFSRKGTRPGLLSIFNYAKESILPQQVKKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IC66</accession>
    <name>A0A922IC66_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inhibitor of DNA binding 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ID3</name>
        <name evidence="9" type="ORF">DERF_001623</name>
        <name evidence="8" type="ORF">HUG17_4719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IC66"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026052">
        <property type="entry name" value="DNA-bd_prot-inh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723">
        <property type="entry name" value="DNA-BINDING PROTEIN INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723:SF17">
        <property type="entry name" value="PROTEIN EXTRA-MACROCHAETAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7641674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9527616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="80" mass="8955" checksum="3C51FCD59F06FCA6" modified="2023-02-22" version="1">MAPASVNQTNEISRMLNKLRTLVPGISPEQKMSKLEIMQHVIDYINDLETVLDQQSNGPDGQEDANKAKGTLHQLRQLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDB2</accession>
    <name>A0A922IDB2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003793</name>
        <name evidence="1" type="ORF">HUG17_5663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDB2"/>
    <dbReference type="OrthoDB" id="6499621at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7642616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="247" mass="29864" checksum="63C2D9DD8949E59F" modified="2023-02-22" version="1">MPRNNTSISESNLIESIIDVCDDYDNNDDQSKNKWNCQMMINDPDSMSAANIILYQIRLQSTANSLNLLIPISSIRDERSKYLLETKLHFKPNEHYWQRDLDWNNVITIGQWEDPTLLTLYDQLYRKIVSIRFRIHEDVNHFRRRINRDRFTLVPWDEWEICQRVGACQWNHYKHTFQQAKYRWPQYVFNIAYVMRGNSSPFDDPDVEEDHKRKDRIMVEFVIRIHKQYKSLRMEQIKKKTSVSSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IET8</accession>
    <name>A0A922IET8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MRTO4</name>
        <name evidence="7" type="ORF">DERF_003973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IET8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000005">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000004">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="126"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9530149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="233" mass="27384" checksum="2B117722F0A5253D" modified="2023-02-22" version="1">MPKSKRNRLVSLTVTKKKNFSNLKERLVKDVQECADKYKRCFVFRVENMRNAKLKELRNDLRQSRFFFGKNKVMSIGLGRTKSDEYRENLHCITRLLSGQCGLLFSNQNQDEIFKFFDTYRHRDYARTGDTATETVELYEGPLEQFAHNLEPYLRQLGMPTTLQKGVVTLLKDFQVCQKGQPLTSEQARILKLLDNQMAEFHMTIDAMWCNDGKFEIFNRQKLIAKSNDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IEW2</accession>
    <name>A0A922IEW2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_001391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IEW2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037563838" evidence="3">
        <location>
            <begin position="25"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9527373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="651" mass="70799" checksum="01C2F4D18968DBC8" modified="2023-02-22" version="1">MAKVLITLLLFLFGTLLMTTFTMAFQSNYPFNDLPFHTTTLIDETSSNDLFELDHSLSMMNHSNCQEIWCELQPNPYNNYYDDIIIGYGEEKRDTGFWLEPPPDDILFIPPPPMPAALQAFFSSMENETMREFIIGEDPIEGVRCNFCKLFSDPKVYQDDDGIGSMYPSSSSSSKSNETFISLFYALIFSLVFVILCIICLLIRYKKFRIFSNYACPVWSSSNGVIGHHKSSSSSSTSPSDTCLSPVVNEKSPQSIIMDASLASLGKKSTISTTGKYWKRVPNNVSGNVLFMDDRRGLRSLGGSSTGISDHPYSDAASCTSSPVYAELDPAVAGCATNQPMIGPLIRSSFGTPTYGGGGYSSSNTYTEVPEGIGHRHRHHLDQRHHALSSNLLSDSSTYDNAAYLSASSQPFIQSGGYNSRSLRRLAAQRSAAINAAAASNQISTPLLSNQQYPPYHPSGNHHRHGFFPTGGRPMKKTRTNGAAPSAINYYKYGNTVSSRQSMMNHYVSNNHETTMLTNETDLSSIIGHNENDVTLFSSFMHNSIPNSNGLEIIGQRNTSASSSQYTEMPLIPASSTFSSQMNAYRGTMSETHSNNDLNSAASSSTTSGGEQRNTGGGTSTNSTGSSVTGSSSTSMKRPLPPVPGTGGIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF67</accession>
    <name>A0A922IF67_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_003245</name>
        <name evidence="10" type="ORF">HUG17_5248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF67"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7642203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9529356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="242" mass="26883" checksum="AC6F23E53F9D9EBD" modified="2023-02-22" version="1">MSTNVNLSSDLNNYLKSSGSSITNHQSQTTSKSIKEWFGGAGSDMKKGWFSYQPLRTSPSDEELNNVGISSPVQNGTSRSNSWFRNLFVSNEPEPKGWFPTLTRTQRIIGFITCFFMGITCFSISAMYIPILLFAARKFSILFTFGSLFIVASFAILLGPMNHLMHQFSKERLPFTAAYFGSLIATLYFALQVQSTILTSIFAIIQVIALIWYVVTYIPGGQTGLMFFSKMAASTVSKTLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG58</accession>
    <name>A0A922IG58_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_002807</name>
        <name evidence="3" type="ORF">HUG17_4915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG58"/>
    <dbReference type="OrthoDB" id="6514152at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7641870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9528899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="372" mass="43366" checksum="B2B2C236654DB389" modified="2023-02-22" version="1">MHYLNIETLPLILYFGSVSLLSLMYGVLKFFQKYQHRRRNKQERNDVDDNEEKHTIKRDRKCSLQQLEQQQSEKKSRFTKWFWNMFIKLRLTNNNHKHVYFPSEQEKRFGIASQTAQQQQQQNTNSYVDITGHDQELTNSTHANITPTSSKVDLSSLESNNPDDDRSSIVTGGVKSRKHPHYQQNSLSQSSCLLEESGSLTRVVITEIEQHQFQRNREIDELNQQQHQKHLEQPDEKNTCIKFQNQNKLTENEKMVVKKIPLHVINNNKLNAAFDFLENETDSDPIYDVPSSRSLINLIDVTEVNLPAKQQQRGHNNNGEIIAYYHTSTPNLLSIKSGVNIKTNANDFHGDYHYDDDEESIYDTPKSRSFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG78</accession>
    <name>A0A922IG78_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division cycle- protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CDC25_1</name>
        <name evidence="5" type="ORF">DERF_004089</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG78"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF99">
        <property type="entry name" value="RASGEF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="447"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="691"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="699"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="754"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9530271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="818" mass="95593" checksum="0FD9E982A1C4D954" modified="2023-02-22" version="1">MSIFNHNNDDNDKMKKKHNGHIHFNLEVDDDDDNDNVVSDDQIDNENNRRHSQDNQKSGWVKKFRFSSLKKNKNKKTIPSEEQNGIIENKTKKNKSNDEIAIKKQKLKLVKYLSTEEPIMKNKIQIDDNERELLATLNPANNIDVNKYFRIPESKINDKLWRIPYGFQLPKINRFGEGVNDGCMIGLNLPKIQSKQRFKTWQQLIECSDEALYQFSHPTTTSGSGRRIYNRQKNRRRGSILQPRPVFLMPNPEMDCLLANNQDKNNKLREWSSELTLDVRHGGCCGEELLDSNFRQNILDNVSIDDLSNMLYPELKLSFNVNGMMTDSEMRYIQAVSNRRRQSLVPPTFSGGDPTAMTFRRQSYGGGQLWSTEVERQQQHECYQDKVALINPEFRHRRQSNRMNSLATQLSIFSDLTITTTTDTDDENSENSTNDNFIEFDPESEEQIILFANELTIIVRKYFNSIKSSEIIHFFLNVTNAMKTCSQIKGLLHFQNRIVRLIATYILQHEQLEQRVRSILFFIRVIGHLQILNNWHSVNLITKSLQCPPVVRLKDTWRKITFVHPEDYCNFIEISEDLEAGNQWLAYETAGRFLPIFDDTIAMIKERCGLMIVQIQQYRFHQSWKNHARVDDHDLINWINQEVGDILKDCGGAQQHLDYRDDDKQERPQRKESIDRKKPLAFWHRIFNRRGHGKADGPMGDDDDNRQQDNDEDVLDVDDDVHQTRLLKGSKNELTNVVRRRRTSKSNRKISVGQLANNNGHSQSSTSSIPSCKQFWTWTDFYKLRQSDREMIKQQIVRTMVNIQKKAFIQSSSVIAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGI2</accession>
    <name>A0A922IGI2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_003224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGI2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46901:SF2">
        <property type="entry name" value="GH04942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="3">
        <location>
            <begin position="83"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9529334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="468" mass="53390" checksum="C3EB5AF498FDA0EE" modified="2023-02-22" version="1">MAAIMVDYDCNDDGEIYPLPRLKCSTFQRHISNHKYWCGIIFLILIATNIEAANYDNVDIILSENIPCLGSWRYPSNCSGFNCDYKATWQYFDESDEIVFTISTKNRNKWTGIGFSDNTYMSNSDAVLGLVEESGRFFLMDSFLKAYEAPPLDYQQNLYNMSAWRENGLTTLRFSRPRQTGDARDYQFSDTDCPYFMFPVMGGVFNAVNKRIRKHESTPIISDERICVHSCQIMSPTISTTIMTTTSTTTFPPSTSNQQNKNNNNNNKESSILPGSDLDTAADKIKIYQAEIKFLNLMDNNKPPTSEVLKMVEHNLHLELKPYFDRVKKIEINELKMDPNNNVAIIDLSISQDDKNEKEDIRALTSALNSIMKDGQIGRWNIDSNHLVVTPKEDKANGWMNLFLASFNRFNEEEQRWIIIGAGLSALLLLALIQLLCMFCSCGCGCGCRKKKSEQEDYLDEKASFKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGU0</accession>
    <name>A0A922IGU0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Hexosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_003593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGU0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF379">
        <property type="entry name" value="HEXOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9529724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="63512" checksum="D32855F69490F9C6" modified="2023-02-22" version="1">MATYQLLPTSSSSSSSTSSLHSHQSQAPVQQRKALSFTILILMVATATLITIIRFTVNPNLNGQTFVQPTNAFAIYRAQMLAVKQQQQQQQQDNHQKRPSLEYSTSDRQPDRPGKQIPTGSQIDGHKFNTVLSRDNPTSIQVVNLDKNINMKSEHVNEKTKPMPLQSSFLNSNNANIIPSSSLVQDLKLNSNPIQPYSVSPSSKSVTSLMADQRFEKDYRDDPVTMSTTGLNLKKSRPKPKAIFDRNDLAETERMSIDKEDGCGEENGAYADLLVLVNSAVFNFDARSAIRETWGKFAVERGAYFYFLLGSTEEQQIQELVEAEDFKYGDILQGAFYDDYYNLTLKTITMMRWVSQKCSKIRYVLKVDDDMMMNMQHACDFTEINPNFHKVIIGKLAKKWKPHRYKSSKWYVPYEAYNQTYFPNFVTGPAYFFTGDAAKPLYETSVNKTIPFYLEDVYMTGIVAETAGIKRYNHAMMRNVHLKLDSCTYPKIMTSHKHKPNEIRELWKSLYSGQKCIKTNTVTRTTPKSKIIITNNTNIGSKSDPSSSLVAKNPSKSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IH45</accession>
    <name>A0A922IH45_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Hepatocyte nuclear factor 4-alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HNF4A</name>
        <name evidence="15" type="ORF">DERF_003343</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IH45"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06960">
        <property type="entry name" value="NR_DBD_HNF4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06931">
        <property type="entry name" value="NR_LBD_HNF4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000026">
        <property type="entry name" value="Hepatocyte nuclear factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000012">
        <property type="entry name" value="Hepatocyte nuclear factor 4, alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049636">
        <property type="entry name" value="HNF4-like_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049635">
        <property type="entry name" value="HNF4_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="259"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="352"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="200"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="648"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="707"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="200"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="655"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9529458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="732" mass="81984" checksum="FFE240C75C75AEB2" modified="2023-02-22" version="1">MLTHTQGPACRFMYASTNATYSGNNIQSPYNYFPIDFNAPQPPSLMFRSPQQDLSDTTGNFFCNGPVDYSGLNNLNSNINSSMESINEHDDAMVSSQSSPEYMANATNNNIDYNSGPIYYNLSNEDIWNNPSLSTVSVNNNDDCMDIVDSVGNNNNNNNKKTDISGCEKMDNARMIQQQKIKDEIRNNYIDSTCDSINSNANNNNNMTTNTNGLTSTDNNQSNNMANMNGNGNGNNQPTTNNENNNNNNNSGHQHIQNSQICAICGDRATGKHYGAFSCDGCKGFFRRSVRKNHLYTCRFNRNCVIDKDKRNQCRYCRLKKCFRADMRKEAVQNERDRITCRRPSYEDTKTTSGTSLAVLLKAEMSSRKNCSPPTDTNFQSKKIANIEDIGNSMTQQLLILVEWAKCIPAFTELNIDDQVALLKAHAGEHLLLGLSKRSLVLKDVLLLGNDHIIPRLTPDQEITRIGCRILDEIVAVMKDVNIDDNEFACLKAIVFFDPAVKNLKDSARVKIVRHQIQICLEDYVNDRQYNSRGRFGELLLILPSLQSITWQLIEQIQFAKALGKLSIDHLIQEMLLSSSTNLAPTTPAASNINSAQNNLPPPPPTDPLQWQRNHLWQGAYPRQTFPEPNMSNMVSNMSQVVNVIMSQEPSENRQQSSLGQQQAPQIQSPLSSNQPTMANGAQMLGQVENIMQQINRQEQSGLINTDDLRSAPPPPVQTFKSEITDTEINPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KTP4</accession>
    <name>A0A922KTP4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructokinase</fullName>
            <ecNumber evidence="4">2.7.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">DERF_014113</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KTP4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000002">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="15">
        <location>
            <begin position="33"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="15">
        <location>
            <begin position="449"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9493361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="785" mass="88811" checksum="3789E7609A6698C7" modified="2023-02-22" version="1">MSTNNCNRLQSSSNDKSIKSTSNKSKRSSTSSNIAVLTSGGDCQGMNSVLYGLTCRHIDTIMATNNSNDKTELYLVYNGYQGLIDGSSRSIISANLKILHRHLYQGGTIINSSRCREFYHQDGRRKAAYNLLRLNIQNLIIIGGDGSLTGANHLRREWPQFVKELIDKGEFDAKNSNSQLNLIGIIGSIDNDFFGSEMTIGTDSALARVVESIDALKTTAKSHSRAIVVEVMGRNCGYLAISTALATQASYVFIPEYPHRSTDEWQKKLAARLQYERNNGQYYHIVIIAEGACDNNGDSIKSNQIKDYLNKDCNIETRLIILGHLQRGGYTSAFDHLMSMSMGIKAYDMIRMKEVEPTAAEEKETADDKSSSSYCIDEMAKLTRFVRERNWPKVMEYRGVNFINTWENYRNLMSPPSKSALSIFDRPKSSTSTSGYCWAIMICSSNHNSPMPGTNGILFALVRYGQAQNITVIGYRNGLEGLYGNDYQRFEWQDVADITSISGSIIGSQSRSRKSTPRINDENIERIITNLQMNKIKFLCFVGDHQAFDHLQSLNEYRKRFDYLLDMKLCYIPVSAVDFDIDNDTNSNDNDSTIVWSKLGRDSMMNKTIRLICDLIYSTQGTYNQLFMIRINLDMLSSTTFIRSNEFAMAVGAAIIYPKDKSNRMEPPLHPESIKTTAIELRESILQTNENKFVIIHYPLWSKIQSIFMSIIAPFSDRIRLNSIDMTAMQMPTHASPFDRKLGVKLGMECGRYFSNANFETTPLMISTPFLYEARPIKSRIRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KX75</accession>
    <name>A0A922KX75_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KX75"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8664" checksum="03832278CBA66F93" modified="2023-02-22" version="1">MSKPTFFWKARRWWCWWNFDRFILSISESEMKLAQWMLNVIVSRHHRHHISSSSSLLLNKNSSLGHTIQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0C8</accession>
    <name>A0A922L0C8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0C8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="211" mass="23803" checksum="C8977F46146D6A7F" modified="2023-02-22" version="1">MITEEEIPYDDEMLNFSFSDDFTIIMGGGSGGVLVFFCVNYSIFKFIHLVGLIVFAAMFAMMTATSFGARLLSEYPEFFTASAFSKKGPSRTQIESTRFRITIIGRGWSKRVMEQQQNKDDIDVEPEPDETIMVQVSGKDPGYMATSTCLVQSGLTILMESDKIPKGVLTPPSAFRNTQLLKRLRNIDNKKNGNKFAPKLVWKIFDIMMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0F9</accession>
    <name>A0A922L0F9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0F9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="564" mass="63260" checksum="F838F86A44B8963F" modified="2023-02-22" version="1">MFIQDEDDISSTASLTNTNLQSVDNLFLFMLTSFASNTSNIYSQPILTKNSHWIHSSILIIIKQTPQQHSSRTRFSFFFLFFDLKTGAMILPLKNFVEIIAIIIVCIIVENSECSDFIINETITLTTTSPDITTSSSNENLLNDLRNFILNLKQNPLDDGSNVSVDQSPPFTTTEGKIIDEINTEPPLIIPKEVKHPPSIEIEKEFPIIHETDKPPPPPPAIRRGFRRPILRKTTSPPVIEKVTMPPKSNSTETLKIFRGLNRPIPSRKFKPPSSTESVVTETPTISIVNKQPPETRRRRPTFLRRPTTIATTTISPIIETQPPSITTLSEMEQSTTESTTITQKVTEPPPTTTPFFTTVNDNPTITTDDQTPIMTTITTKSPRKTKSRTGKKVPEQTKNVDLVVVSKTNRPISKSNKNCSNDWSCRGAKTCNDDDECNNHNAITTTGATNNGKNDNRKTSRKNSNRSRSRNSKKSKKNGKRISSTSTTKKKAAEQIQIERQPHCEMVVCELPCYIFKSGTDVCPECSCPEANSDRIQFIATSGFEPAFRLSNKRNQSRVFRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0L7</accession>
    <name>A0A922L0L7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_016714</name>
        <name evidence="2" type="ORF">HUG17_1185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000010">
        <property type="protein sequence ID" value="KAH9490516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0L7"/>
    <dbReference type="OrthoDB" id="6490614at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324755" evidence="1">
        <location>
            <begin position="31"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7645647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9490516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="165" mass="18195" checksum="DDD79BBAB66878BC" modified="2023-02-22" version="1">MRIYNTISLKRISIILSTFILLINDQLDYGHTADEQCNCSVEKNGEYCGTQLNELNKENSCPKKMFYCGDTNHNKAAVLLVDCQQGQECDVRTLLSNACLKNIECECPKGLTKGQTYCGDSLTGKDCSPNITFTCPRLSMIFHPSPVDACLYGCKDGVCLSAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2E7</accession>
    <name>A0A922L2E7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_013542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005312">
        <property type="entry name" value="DUF1759"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="539"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="1049"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9497565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1353" mass="157454" checksum="D132C0514C6A73AD" modified="2023-02-22" version="1">MDDKKKQRTNLRSKVTKKHGDAVLNLLDRNETTKAEIIKLIKDLSEVETELLEVDFDEKTFESYNCKCQVLVNYFSETTTTTTASNMERTIKYQRRALPTFDGDIIQFNLFFREFMRIVDGDSTLRMDEKFFALKSMLKGEPLRLVGNLLENGVNYELAKNILKERYQDKQRISNIIIDRIKMLPVINVNDLDGMQRTVDEMGCLYREAIDHGMDSYVIEEVIRPTILSKWYSPEAARHGSTCSGLIDFFVQDVKVYIRNRDLITTNQVNQVSTRPNCIFCRQNHKSIYCNADMTNKDRKDIAMKKKLCFICLQSNHQSGQYHSKKRAGRPNGLIYFNCLVNNKPIRAFIDTGAEITCISKNLFDQLKLQIIKNSIINIRQLDNLTQSLGRVKINLQIGRITRCVEAHVVRNLTTNLLLGLDNSQLFDLNLDLNNNCLKQRDKIVNNVQNSSNQPCQSVNRNQQEYHINQNLNGNQRRRIREMINRYGDVFAQSKSDVGYINHQHHRIDLSNEMPIFLKPYRTSPREQKIIDETVHNLLQQKLIRPSTSPYSFPVTLAEKKGEGKTRMCIDYRKLNDVTITDKQPIPIIDDIIDKLYGKKYFTKFDIANGYWHVPIAHEDIPKTAFSTHNQHLEWLVMPFGLKNAPATFQRAIRGVIMKHQLKNVENYFDDIIVFSDDFEQHLVDIKKVLEACEKENIKLKPSKCHFAEEKIEYLGHCISFNSVQPSKDNIRSIENFPVPCDIKELQRFLGMENVYQKYIPNHAVLRKPLTDLLVKDRPWEWSAECQEAFHEIKNCLTKYPILNIFNPNLPTIIYCDASQAGVGAVLKQKHPDGEELPVAYYSRKLLKHEINYTITELECLSMVESLKKWHCYVDGNPTTIITDHAALQWLKSCKRLNGRLFRWSIRISMYDLIIKYKKGSTNYEADALSRAPVNFVKVNLLTKEELEREQQNMSDVNKFEMVDGLRIRRRKGLEKIVVPSTLRSKILNEAHNRFGHVGTKKMISLISPTYYWPNLICDISNYVKHCETCQKNKRFKEKKFSTLGTLPPSSQPFDLISIDTVLGLGKYGSRKNLVHLVMDHCTRYAWVFPHTSTSMETYIEVVKQMLKVGPIKRILSDRAAAFLSKRYQKFLESNNIKRLLTSTQNPQCNGLNERTNQELMKRLRCKINDPEVKCRNWPTLMEQVVHEYNNSPHEATGFSPAFLLYGILPYEQFKMNNQVTIEEAREIANQHSQEHHRKNEETYNQKFKRPQFQVDDDVLVEIAWHPNNGKLTPVMEGPYKILKIVSESNVEINRPNQPTKRETEVINVNKLRLYHHPGKFKIGAGRCHDSYEGVVSRNEKHNGFSREREQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2J7</accession>
    <name>A0A922L2J7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="8">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_010843</name>
        <name evidence="11" type="ORF">HUG17_9558</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
            <tissue evidence="11">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H. Proline is synthesized from either glutamate or ornithine; both are converted to P5C, and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCR3 is exclusively linked to the biosynthesis of proline from ornithine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodecamer; composed of 5 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7642867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2J7"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="10">
        <location>
            <begin position="181"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH7642867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9506096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="287" mass="31692" checksum="C4C7BCD3DF36EE0D" modified="2023-02-22" version="1">MDTKDLRIIFIGAGNIAQSMAKGLLNCSYVKCEQILAYAPSDRNLKTFQNFGCHTTQNLHQIFFDSQSSDVHYLLFICVKPNIGKDFGFWSSLKDKVQPNQWDKIFIVSVMAGVSLQTIENYLSPSLKHNLARIMPNTAMAINAGTIGLYWKPWNLTQKLWSEKLPELLNKLGKCQQVDNEEQIHSIIGVAGSGIAFIYTVIQAMCDGGVSVGLSRQMSRELVTQTVMGAAKMVTETGMNPIELRDHVCSPAGTTIAGVEMLEQGGINATIINAVKKSTERSRELSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2Y6</accession>
    <name>A0A922L2Y6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2Y6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="91" mass="10736" checksum="86C34AC0CC6ABD73" modified="2023-02-22" version="1">MVDMIISNKKKKFFGSIYIDNETIYDHDEKKKRMLVKKKEPEELKLFERNKEKDSRTYEKKITMSASRNNIVDNKANENSMGAKPYNNGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3A0</accession>
    <name>A0A922L3A0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_012240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3A0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9501393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7702" checksum="E1105A20B4372EE3" modified="2023-02-22" version="1">MFEPDEMMMKRVFFLLLMFAHKQNMQAVRSIQAGSLNLSAFTSYPQQREYILRLLDFLFFPYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3D4</accession>
    <name>A0A922L3D4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Metabotropic glutamate receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GRM1_1</name>
        <name evidence="15" type="ORF">DERF_010277</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15285">
        <property type="entry name" value="7tmC_mGluR_group1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000145">
        <property type="entry name" value="Glutamate receptor, metabotropic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000001">
        <property type="entry name" value="metabotropic glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1092"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1130"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1162"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1200"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1250"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1284"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="1092"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="562"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1348"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1462"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1490"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9511851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1599" mass="182883" checksum="CA100B670A980D80" modified="2023-02-22" version="1">MNKWNIESTTLINTMITIWKQRLTSIDIDVKIFVANFGNKYHHHYYELYEYGYKSYDDHGSNLFGSFTYIGHNNHEYQHQQQQQQQQQQKYYCNDDDLSSMEYNLQQQKCCKFVFGTYVAIIIIVSADHIYQNSQQQQQQQQQHDKRNRCRRFIESMSIYNIKFTSIFVNDCCVVSNNSIICIHFKYSILSSSSSSSSSSLMLLQMEYILLIMLMQLLCYWQHVIRRSQTSSSSSSSVLIIADTELINIEPNNNKTMCLLWYYDSVDSINYNDDDDDDNKCLNRQNNFQQKLKKFSLPSLFSLLWSKDQYQHQPNNSDQYQWQRSSMPIDSCQQQKQQHQLQPLVPTYFSIHINIIIIIIINLIYSIYLKCFQFLYQYHDHKSSLLSQKLYRSSPKRTIYTNKKTNNDHIIIIIIMMAILSLIIYPIPIVRGQHAKQVATIPGQLVIGALFSIREQPTLRAAQTRTCGEVREQYGIHRVEAAFQTIDTINNDTNILPNITLGIEIRDSCWYSAIALEQSIEFIRDAMAASEEKAYGSSSSSSSSSLSSSFFRPGSVYSVHDDDHLLSSTTHNNNDDDNNNNNNNNDDDDDDDDSSSKQPRILGLFPASPFSGSPQRFNVSTPCPKATKKAKNIVGVVGPASSTNTIQVQNLLQLFNIPQIGYSATSKELSGKNFFKFFLRVVPSDHHQAQVVSSLFRYYNWTYISVVYTDGSYGSGLMEIFKTNAQDVGICIAYMESIPPNGDDESLLEFKNAKVVACFCEGSSVRALLQAKRRLNVTTEFMLVGSDGWSDRPDVVKGLEKEAQGSVTVRIYSPIVEEFDDHYFKLNPLANHRNPWFREFWEAKFNCSLRNLTGQVIVHPNNVTFTKQCTGDESLQDFVVRRKPRYKQDNKMSFVVKAIWTMAHGLHNMQKSLCKNVTGLCNEMLPVNGSILLWNLNNARFRWKDEIVEFDENGDPPGRYDIINYQELKKGEYDYVQVGEWNSDSNLSIYRPIQWPREREMVIQSNYTEIKVLNKHTSIPESVCSKPCPKGQAKNIQSDSVKCCWICVPCRENEYLTSEEKCKPCKIGTWPNENLTGCTPIPIEFIRWTDTWSLVAMTISLIGFIITLFTMIVFIKHNDTPMVKASTRELSYIIMFGMFLCHSTTFALIAKPTKLTCYITRILPGLSFAIMYGSLVTKTNRIARILAGSKKRIITKKPRFMSATAQVVITWLLVSVEVGIIITILVREPADKMLKYPTLDRVVLTCNTKVLGISAPLGFDFVLIGFCTLYAIKTRNVPENFNEAKFIGFTMYTTLVIWIAFVPIYYNSDENLYIILFKPEKNNRSYFTTAKNVRCHIGYMQAATSTTTSTIQSQPTATSAVSRHSSHSASDFSLESPRNHSIDVCYRKPVSEISTVHNQYYTTPSYSGTHLNHTKIPQRRNGHVKKGFFSRLRISKQDKIAANVAEHIRAVRAAEALDRQTARGRRFHATSQSFSEKHEEPTTTTTTATSMIGNEPTTTRQEDTVGILSRQDTATRRIRIIHLLRRTFGEELEKLPQFSALVNCLKYECSHTFTECAVQTGNGGNGNNGMDTLRRRLTSIPADVNLLQQQQHENGFSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3P9</accession>
    <name>A0A922L3P9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3P9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9515830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="100" mass="11656" checksum="899196CBA72DF801" modified="2023-02-22" version="1">MNSELKKNPHKCYPESIRRLEIEKISFNSRDTITILILPEDILYSIEQIHFPNSIQCECKTIIAYKLLNVMINPAMAIYDNHRKDIGIPKIINNDQEQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3U3</accession>
    <name>A0A922L3U3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-associated and pleckstrin y domains-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RAPH1_1</name>
        <name evidence="3" type="ORF">DERF_008011</name>
        <name evidence="2" type="ORF">HUG17_2294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3U3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7646756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="248" mass="28395" checksum="047DDF6150881D5A" modified="2023-02-22" version="1">MKQENHYMSISPHLLQKHQQMIQRHQQQQQQQQPPVNYCPSNTIYAGNNNSNYNDNNVPYHLPEDLFLKNMERVMQKKWHVAQMLQQDQTATPGQVLGFRDSAYLPPPPPPPTDNSYPNIIPPPPPSSNHHYNQSYNHHHQQQQQYSLATANHYHPLPYHHQMANNQPKSVQFSDNGPIIMNMENISSASSTTTTPMTSPIHHQPNYNMTAVGGQNHQMIGRSKIPPPPPKRSESTQLTVVTTCPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4C6</accession>
    <name>A0A922L4C6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Teneurin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TENM2_3</name>
        <name evidence="8" type="ORF">DERF_008082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000013">
        <property type="entry name" value="Teneurin transmembrane protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057627">
        <property type="entry name" value="FN-plug_TEN1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056822">
        <property type="entry name" value="TEN_NHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056820">
        <property type="entry name" value="TEN_TTR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057629">
        <property type="entry name" value="Teneurin1-4_GBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF69">
        <property type="entry name" value="TENEURIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24329">
        <property type="entry name" value="FN-plug_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23093">
        <property type="entry name" value="GBD_Tenm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25021">
        <property type="entry name" value="TEN_NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25020">
        <property type="entry name" value="TTR_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="496"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1760"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1762"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9517406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2978" mass="341388" checksum="EF6F55931B650564" modified="2023-02-22" version="1">MAEDLLSSTNRLVVSHNNHHHHLSSSPQHQHHQQQQHYSAIMHTYANPFQTCNISSSGGGYSTEDTTGPIIPSDLNTMRPSQLLKNSFAGSGPAPASLQSNHSGGVDHHDNHNSLVSSSSYVIQRLLSYFRAEHKQQPPNDDDDDDDNDNINLRNRCCCGTDSSSSSSWLRSFSTITLIILIFILIIVIIFLTALHKENITDNTTATTFRMKPQNIGDINRVPCVVIDDMDHQQQHSTSHLPTVTSNQYGSQHFNHDHDLFVSNCPRYFPRDSSQYKEINLFHNQNRPPHTMSISSSPSPSMPISLRLTPFSSWSIWFNQIESSSLHINFQFYAPIHTRLALVANKNEPPSLTMHQIFQVISDDEDTLLVEDSISNSNHIKRDSQLAMMQFEHKFDQGSWYLSLINDFDIIIPLVVNISIIQNQTLQQQPQAINCMNNCNNHGYCSGDGRCHCFPGFIGTDCSDNVCPIFCNGHGQYLQGSCHCESGWKGRECTLRSNECEIADCNGNGLCIDGSCHCRPGFKGNDCEQVDCIDPECSGHGICMDGNCFCKAGFAGTNCSEMDRKLYKFLPNCSGHGVYDFENDLCICHNHYSGSDCSKLSCSLNCGQNGLCHEGRCHCNDGWYGSNCQYKKCDIRCLEHGKCYNGTCHCQNGWMGKHCTLNGCPNTCSKHGQCVPIATANNRDDFDVVDDDHNDSDDNAIEWRCKCDSGWHGYDCSAPQETNCNDEIDNDNDGLVDCADSECCHHEQCGHQSLMCITSPDPLDILLRKQPPSPTSSFFQKVLFLIEDGSVQSYAQKDVYSPKRAAVIRGQVVSKEFNGLIGIRVSVVNDLKYGFTLTRSDGWFDILVNGGGIITLQFQRNPFYPIKKSIYVEWNDITVIQNPIVMYLGPSQSPSHSSSTTINNDQHHHHHGNEFRGFSFNSRIPFVFHNLFSHSDFGESNWRKWITRRGFYNESKPSDSDSSSTSQSYRCLEHHYEHMRPMIRDHHDLFQSSKFFPTPNNEPICDKDNCIIAEMQTVHEKIRIGTTRLFVVYQSSQSSGYSSTMDIQLTTDNVPKSLRFLLLRILIEGNIHEKIFESDSNIRYTFTWNKQNVYKQKVYGFAQAKIYVGYYYHDCPHILWTAFTTKLLGYVMEISEIGQWNLEIHNRYNPYDGHFQRGDGQFLSFKNNPRLPLVIEPVAGLDSHPRSFACLNPSECNTDIGSSRFFSLVTMTNSADGSVFVGDSNLIRRITPDGQIYTVYKLRTSTNRQNFEYHIAYNSIDQYLYIADPERFQIIRVPIQEKYEPNQEITMPEAEIVVGTGEQCFPHDQSSCDDGKTGVEVQLIYPKDLAFANDGSLFFSDGNVIRILDTNGYVRRVVGQFAKRQWKPISCQSMHSSDHIKLKWPTSLAIHPLDGSLFFVDNHVLFKLNQNMQVSILSGYSSFCLEDSDTIGHNKNNDTIDCDGPSLNAQTMSLCGDEFLFGSIAFAPNGVLYVADISRRNENRIFAYMHDGSLRHVAGFRQKKSRHQVQCPVEKCIDMAGENCTCLITDYESNDDSTIEPKIALKARLNSISAITITGDGTVYLADEGQLRLYSMKSYLPQMDDQNEIKILFPNTAEMYVFNKYGQHIRTRSITTGRTLYSFVYNHENSLGKLTQVIDSSGHKILFIRDQTGSLHMIESTSNALKCRITINKQGLLESFMNGGNISVNFDYYNNGLIRSREESLTGKSYFYRYDRNGRIRHFIQPNGALINIYSSSIDHDQHHHLTAIEMPLFIMTKYHHQQQQQQQKQQQQQTTSSSNNFDKQHFLPIGQQQITDLIIGDNSMMIKFSQHGTMFELTSLNDGSLRLNTSRQIYAHLNGKISKLSMDMLAIQAQLFPFISKFTLAQMNHGRDQQLQTSLDMEIDYNLRLKSSFIDSVEKLIKINDNLTMKIEYDWNANREIYYNQSQRPILFLQYDDYGRPIQWIPNIKEHWQAHSVTYDKLGKLDTWQNGQHTQHYQRDRVGRLTELRQNDHQIRYSYPSSSMDMTTTDQLNNPGFSLPSSIILKSGHKYIVDLDNVGRIQSIITPKGARHNVSINVVLGAYRFSYCPPPPSTQIADINTNIHISPSRHCFHIYLDEKWQSLMRILPYDMGKIIHHYKSKISFTKDQAKDFLRLNQENNNNNNNNNNIITIDRMIHGRGLIERWYDEKNQRTVRGIWINNQMEFAIQYKYSRSSSSLLKHQSYLFSSNIHSSIAQFSYSYRYDNQMRLRSIQSKLGSITLPNCDFTYDSKGQIESIGNFRYFEHSYNETLIGDGIALLVRRYDPIKQRRIRHNSLTVSDKEVFRSDFIYDANGLLIQTRTFMHHLGANKLRIQNYTYDMDGQLIEMQGREHWRFVYDPNGNLITFLYMGNRVDIEYDWADRIRNFIKSQHNSAITGGGGGGVAGGTTPYVSDLRGFITQRGDEYLYYNNLGQLLQAITPNRYEVNYAYDYLGRLILRRDHQKNVTQYFYGNPSKPYLVTHAFNNANGAVLSLIYDDIDDSLIMIRLNNENFYVVCDQTQTPSLIFDHRGQVVKEIHRSPYGYVLFDSNPNLFVPVDFYGGIADPLTNLIHFNGHQQQQQRLYDTLIGRWLTPNVDQLLEKNLIKFPRFVNMYQFKQNDPINNNNNNNDQYRYSGLKDWNNHGGGVEIMSLSQIQTSLLQYTSSLVNQDIGHQPQFDNNNNPILLTQFTSMFENIHIPNLKSSTISSLQTLLLDQVQKFSTFQSNYYSKQLTQNDWTDEQNGRELITMKNALFGQGIVLSLMIKPNAISAVAGHQSTDILCVHFSHSITDNLLRESLNILVNGSHLLDINLIMAGQDHYYLVKDLADNDNLRPLMAKFKQYQSRLNLTVQEIHHNDDKRMMIEVRIYQPSVIWNIRFGTTVAEERERVLMMARKYAIQQRIEHERIQIVHHHHHHGNGNGGYSQWNEQEKQFLMNVRNEENLLYNSIGLLRADYQYSLNELAEDPDNIVLKKRSAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5H5</accession>
    <name>A0A922L5H5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5H5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="154" mass="18607" checksum="1A9C2845935746CB" modified="2023-02-22" version="1">MEFRKQKLPKKFVAKNLMNIRRQKQQQQQQQQRNNMMKTRNKINNNDLRIGAFVQPGNFTLGNLLENLFMPFDDHNEYESLEFIQQMNDLKTPREKDDEQIENLYKIMNESETIIADTIEKQMIKESIMDENYDDEIEKIIDKIQKHSKIHDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5P7</accession>
    <name>A0A922L5P7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5P7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7073" checksum="784764A2630F657A" modified="2023-02-22" version="1">MTCNMVANNQNKKKFVMLLADPHHPLPSSSLLLLQFAKTNKIQNANNFHLLLLIVIGIVFDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6H1</accession>
    <name>A0A922L6H1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6H1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="127" mass="13289" checksum="D1F2108044FB0608" modified="2023-02-22" version="1">MVIAALCDANVNTVKYLATSNGMNNTIDGNHVSANWNGPTIAFTGACPTTLDPRPPEPHLSVYQCHDCVSGGPVHRARQLDMCHGAESHCGLAGGGWHQVYDQTAGGVTGSRSDAQNSELPVLTCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6I7</accession>
    <name>A0A922L6I7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007982</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6I7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9313" checksum="C6DA49FE46D7272A" modified="2023-02-22" version="1">MIVLEIHNETILVRYVYPINMNIDSNDRIHILGFCSYVSLIISNTTFNPIEIVFVPYCCCLNSSSNNKRSTNDCGLFAFCAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6T9</accession>
    <name>A0A922L6T9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6T9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="278" mass="32906" checksum="8BDAE2A565CDFE2F" modified="2023-02-22" version="1">MKKFRNGGKLTGKNMKTILTRTKLDLNDLLEKIRKQRSDLSKQFTTTNQNNNENIDNHHHHLELNAKPSIRLFQKPWLKRKNVQSQRENQPSKQQMTDFYYERYTDSDFTRQDDVDQNCLYDINDEKNSLFYQNLNEYPDYCGQTSRYIPYLSVIPFYTQYSNHELNRLITVGPSIQLQSSKSKDRKKKVSKKKSTSHRISNDDSSLMEDNDNPSLRLNLDNNDINSININMDNENMPKTFQRESLIIMNNDDVNNEDDDSNSNQKIRMPEKYSILDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7K2</accession>
    <name>A0A922L7K2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SUPT16H</name>
        <name evidence="16" type="ORF">DERF_005851</name>
        <name evidence="15" type="ORF">HUG17_3227</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7K2"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01091">
        <property type="entry name" value="CDC68-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000003">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000005">
        <property type="entry name" value="SPT16 homolog, facilitates chromatin-remodeling subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033825">
        <property type="entry name" value="Spt16_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="12">
        <location>
            <begin position="11"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="13">
        <location>
            <begin position="546"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="14">
        <location>
            <begin position="824"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="945"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="946"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1002"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1052"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1076"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7639194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9522263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1089" mass="125257" checksum="CBFB49059A697573" modified="2023-02-22" version="1">MSQSQSLSISIDKDAFFRRIRLLYNAWKNGHDEESYANLVKCDAIMVSIGQENEVLYCKSSAIQTWLFGYEMTDVIMVFCKRSIFILASKKKVDFLKTIESGKENEESVPPVTLLVRDKSDKDASNFEKLLNSIENSSTGKNLGAFIRDKFPGEFTVEWQKRLDGKKFNVIDISIPIAYIMATKDDHEINLITKSAMLTCELYTKYLKEELTRIIDEDRKVRHIKLTEGVEQASQNKKYIKNVDTSQVELCYPAIIQSGGQYNLKFSASSDSKILHFGTITCSVGLRYRQYCSNIVRTLLVNPTEEQKKHYEFLLTVQEVILDRLKPGANLADIYQTAVDMVAKYDRKLVDKFTRNCGFIMGIEFRESSLQIAPKSMAIVKRGMVFNVSLGLANLENREAPDEQSKIYALFIGDTVLVKDDKQPATILTQSKKKLKNIAIIIKDDDDEEEEEEEQEDKMDDVVKDALQSRGRRTAVIDTKLRSEATDIEKRRQHQRELAVSLNEEARARLAQKSGHKGEERARKSTISYRSTQQMPQEREIQELKIYVDKRFETIILPIFGIPVPFHISTIKNISQSIEGDYTYLRINFFTPGTTITKQESSMFASNANLTFLKELTYRSTNLKEAGEISAPSSNLNTAFRLIKEVQKKFKTREAEEREMEGIVKQDQLILSNSKTNPRLKDLYIKPNIIAKRIHGTLEAHQNGFRFTSIRGDKIDIMYNNIKHAFFQPCDGEMLILLHFHLKNPIMFGKKKQTDVQFYTEVGEITTDLGKHQHMHDRDDLAAEQAEREMRQKLKSAFQLFCDKVQAMTKQEVDFDLPFRDLGYYGVPNRSNVLLQPTSGCLVNLTDWPPFVITLEDVELVHFERVQFHLKNFDMVFVFKDYFRKVATVNSVPMNMLDHVKEWLNSCDIRYTEGIQSLNWAKIMKTITDDPEDFFENGGWSFLDANDSDEGEAAEELDEEDDAYDPSESEFDDNEESESEYSDESISEDESSDERSLSSSEESGKDWSELEEEAAKADRNLGEFVDDYTAKKRKVMSKGSGGGKSEKPSSNNHHRPHNNHHHSNNSMKRRADDHHSKHSNSHNNKKRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7N0</accession>
    <name>A0A922L7N0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7N0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037253401" evidence="2">
        <location>
            <begin position="23"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="576" mass="62005" checksum="DCA255984CDC3B9F" modified="2023-02-22" version="1">MKLTTTLLLILTLSWLSIYVDANPRFKRDNRDDVLKQAEELIEKGEDVLEKLPDSDLKDEIAEKLATMKHYKHELENAKNPIKIAHFELELLTMFKKFKTLLYEADEIIKSLTTTTTEPTTSTTTEPTTTTTEPTTTTTTTEPTTTTTTEPTTTTTTTEPTTTTTEPTTTTTEPTTTTTTTEPTTTTTEQTTTTTTTTEPTTTTTEPTTTKTTTEPTTTTTTEPTTTTTEPTTTTTEQTTTTTTTTEPTTTTTEPTTTTTTTEPTTTTTTEPTTTTTEPTTTTTTTEPTTTTTTTNDNHGTHNRQPQLRNRQPQLTKPTTSTPKPTTSTPKPTTSTPKPTTSTPKPTTSTPKPTTSTPKPTTSSPKPTTTSPKPTTSTPKPTTPTPEPTTKTPEPTTKTPEPTTPTPEPTTKTPEPTTPTPEPTTTTPEPTTPTPEPTTPTTEPTSPSPKPTSPSPKPTSPSPKPTSPSPKPTSQSPKPTSPSPKPTSPSPKPTSPSPKPTSPSPKPTTNRTTPSPKPTSPSPTDTQVRNRHHQVQTDITKSETDKPKSETDITKSETDKPKSETDITKSETDNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7R3</accession>
    <name>A0A922L7R3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding protein Nova-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NOVA1_2</name>
        <name evidence="5" type="ORF">DERF_007212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7R3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09031">
        <property type="entry name" value="KH-I_NOVA_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047274">
        <property type="entry name" value="KH-I_NOVA_rpt3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9516477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="238" mass="25194" checksum="40120FF5FD3C6135" modified="2023-02-22" version="1">MGLTTGTPTNNCGIQMNQNTLFSQGGVPGLDQSCSNVPQPSGNGGNNLFGPVGSVGNSLSAMGITHGSFTHNSSPAGRQDRLHMPDGSVFETFRSSPSLSSPGNNNSNVHPSMSINNNSFGIGALHSPNSMRKSPTPTDQSDLTQNKLELEVSDNIIGAILGHGGKLLVELQRSSGANIQISKKGIFAPGTRNRIVTISGSQNAIQSARVLIEHQINEEESKRSNQQQHPQQITNFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7W9</accession>
    <name>A0A922L7W9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7W9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="271" mass="31162" checksum="2AF790A12BC0DAE8" modified="2023-02-22" version="1">MGSICSRKSFIGIEDDQKRNAKTMEKFSELSSSIYNSRQGSSSSSSSRSTSKSLSISKTKIIQQPSIQLTSCPRLPHSKPLIPTIRIDKKKMVQILEEENVFRRVVSKIGFNTLKQNHRAQTKHRKSESAIKQQFSKSMCKKILSETIKRRIIESSGGIKSYRNDEYNAKLTTNSKNSLRTKSTTSNPSSPASFKSDISIQSRSLINRKQIGKVKHFPLYIESNAWQLKEKFISKQKKLKRNLYENDREKQYSWFVTNDKKIPTKQTTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8Y7</accession>
    <name>A0A922L8Y7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_008234</name>
        <name evidence="3" type="ORF">HUG17_2417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8Y7"/>
    <dbReference type="OrthoDB" id="6522495at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038277032" evidence="2">
        <location>
            <begin position="16"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7638384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9517572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="545" mass="62987" checksum="B3377268CE4D502B" modified="2023-02-22" version="1">MNFYLSTALFALVYCSMIDIQVSSLHHANISPLKTIFDVNESKPLLNKIVLDGFFEPNLDVSNNDDESETTTTKVTGSEQLKDLKVCVSLTPGYSSTRKNLVNYECQARICTTGDFDPIVDLSNDDNGYHFERPMFDWKTELNHLLLTNSSCDAERKFCKFNLDINVGNFVQEMERSGMKEMKISCNVADFIRINNDELGRDNRYHYVSGQADAFVKVFKGNRIHQTCNRTSDCGENMVCNPNSSKDQSSMSNNGYCECPNESIQIQVERQSGTDVRLNTYVLVIDHHYDELVCAKKRNLNESCQYDQQCSSLDPNSYCRPIYSPRGFATRSSICDCQFGFVEDRRAQSGKCVNVYSTRDDEQEEKKGPPDYRLSNYPTIVPKGVYVWWIIRPNNSNYTNRITSTYRFLWQRYTHQRYITQLLMAVMLFIPFFVLLISSTYLHYYRRMLGKRQYKPTLHAMNSISIPPSIASNEHISHKSNNSDMKKQNIHPISMSQGSEFDNKSIQHTTYNHHNGNNGQGQKKMDKMELIKNDQLNQFYQIQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9A8</accession>
    <name>A0A922L9A8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/potassium-transporting ATPase subunit beta-1-interacting protein</fullName>
            <shortName evidence="7">Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_008548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NKAIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9A8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008516">
        <property type="entry name" value="Na/K-Atpase_Interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13084:SF6">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13084">
        <property type="entry name" value="T-CELL LYMPHOMA BREAKPOINT-ASSOCIATED TARGET 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05640">
        <property type="entry name" value="NKAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="252"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9517932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="475" mass="53442" checksum="913D97F857D621CD" modified="2023-02-22" version="1">MSVRIIIKIFLTLQLLLLIFRQMIDFAGIQWLMILVNALAIIITITGFFGHLLIYASFQIFLIIYNIYVICVYARFITLDTITDTFGTGDMSSLSLSSATTTTNLYKSIIDDHQSNYPIVHTSPLLPSTQLLSFDINSRSFWYIIVSNHISNIQAHLNHYNQQQQQQQNHNINNHNHESLVDLCVQYIEIAIASLHIFISILAIGLILLKYKLERDKFLRNNDKTTPPLPPYTINPQMNHYMSFTPTTITTTKSSLYNQKTNSVRRSSKRRRSTRSLHTQKSKSNSLGALNNIRANSSGSLRSTISKHGHHRKSATSLLMMNNNNNNVADASFISSNNTTIGSRSGAKSSHSNYGQIINNNNNNNNNGLYGTIISTPVNKPTVPLRNQQRQHQNLQHQQQYSYRHSIYGGGCGGGGQQNSISSVGQSNYGPKFVTSDSETDNYYHTFTPAYLNNGLANPLYGKRNSYMDSSETAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA16</accession>
    <name>A0A922LA16_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA16"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="104" mass="11648" checksum="D1C378B42612BF22" modified="2023-02-22" version="1">MHIVHMILNIYVDVDSIATTTTKEKDEKKIDDDHSIGLINLRKKNGPNSRPHSKIEIAVVLANCGPGKEGNMLYSSIDSVNNFHSLLTFVIFKMAKHLESKNCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAY2</accession>
    <name>A0A922LAY2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">POU2F1_1</name>
        <name evidence="11" type="ORF">DERF_001211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAY2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF76">
        <property type="entry name" value="PROTEIN NUBBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="10">
        <location>
            <begin position="612"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="762"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="764"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="257"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="492"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="725"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="821"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="919"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1048"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="528"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="574"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="823"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="938"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1059"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9527172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1072" mass="115460" checksum="AF643743CEE9F0BA" modified="2023-02-22" version="1">MLMAQHHIDPQQFISGHHNNININNNNGNNQQMSNGGHHHLNYNNNNQPQLTQAAFAAATAALATAAAAAGMTVNQLIAQLMAQANQQQMFLQQVQADLLQQQCKQQQQQHPQQLQQHLMSISSPPPPSSLTTATTMNISTSSTTTTTMASTNVQHCSPTTQSSTLTAAAAANCLFPQLLAAAASSTTSPTISAASTSTTTAMNSPQQLLPSMATIQQLQAQLLLQNQGLFPPNILAQGLQNLAATSAAAAFLNSPVSKGSIPSPSAPSPTLTGGTINHHSHHHHHHDDHKSPSNSLEHRLNLLSSTSPNPSSSNLIHHNNHPLSQHSIPHHHHLNSPGSLLQTLQTCQTPLISGQSINNNNNTSNISSNTIGYECSISSPSRASEAINISSISNNNNSSNNNNNNVGQLSPTQLLQQYHKNVSSLTTGSNNLLIMNDTNKQQQQQQQSNHHQNNQSNGNDQLIIMSKQQQQQSSSSSSSIDNTNIIDSIGSTISHSHHHSNNHHNHNHHHHHHHHGTNTQSNRSIRSPSTSQTSTSSSSSTTAGHHSHNHHHPHQTLCKAASTMPSAVLMNNQQSTGQSGQQQQRANSNNNTNNNSGTGTGNNSISELNPDEMTDLEELEQFAKTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQRWLEDADASLNNPGGSVLGNGGNNGGVGGANGGSIASGLLSGSGSLQPGNGNGHGISGISGTGSSTNGSSSGCAIPSVDSLSGRRRKKRTSIETSTRVALERAFLQNPKPTSEEITMLGNSLCMEKEVVRVWFCNRRQKEKRINPPTTTSSASSGAASNSPGPSSPLSLVFGGQNFLDEQDDDDYIDYDDDDDDDDEDYDATNDGLKNNLHFTGHFSNLNHQSRFQSIKSEDDFQQDITMNKLSKQRDNSSLKTGNNNGRRKQSQHSINHNRHSNSVSPTTTATTTIPLDQLELNQQQQQHNLVDSIIISTIKNENDDDDDDQDHNDQDDNDDDDDELITSNGRGKCNDEITIQQNNNVNMMMMMAAAAAAAATSAGNIQQSSPNNNLQQQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB77</accession>
    <name>A0A922LB77_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB77"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="480" mass="56854" checksum="490F068B0BCEC3E4" modified="2023-02-22" version="1">MKELFQSTLKTIKNSSSKLIREKYRSTIDWNKFLFAILRLILLIIVLINLAFHSIYWINYSNQHSFENDRENHLVMAVFITIFLINLILMILTFNDSIKTLIVCVVIAFIDQWFITRVSLKHGLYRLLIGYHSFLINMLTYACFIVYSIIRLVKLNDDYNAQTAKNRAIDHNFQERKMSSFSKKIIHLIVILCTFSGINCWNDSEEQEQLSKLIHSFNQSMSIRNELLGINKTYYDIVETNHMELLGRPEPDLRPIIDSFLKNLQEIQTKLKDFHKRFHWLREKMMLKSINRRFNCLEYEDEIIALNDSITMVIDQLTPYRIKNAALPSSGFDSQILNQKLFKFKEDYPSYSDMEIIRREFITLDKKIKIFLEDPTKQSQLIEFLENSFQHSERINQELDRIRQETFVQARTRAQHIPVIIDYNLVFISRMHRDVWNISRMYLDKIKSGADLSSASQTIRLENLGLMLAIILMIITNSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBE2</accession>
    <name>A0A922LBE2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBE2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34410">
        <property type="entry name" value="INTRON-ENCODED HOMING ENDONUCLEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34410:SF2">
        <property type="entry name" value="RRNA INTRON-ENCODED HOMING ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="233" mass="25582" checksum="DD3350F8BCFB138E" modified="2023-02-22" version="1">MDNCGNSRANTCRKASSSWWSAFIRPRPKVATPYNEEVVTKNNNTGFAYMRSRNWNEYNLNPLTRINWRASLVPAAAVIPAPIAYIKVVVVKKLVVGSQLMHGGPLDGGYCHAEQNIALSHVLKAGINCLNTVAWNNGIGPWFCSVGLRNRAKAFVKNVFINQERKLEVRRRSDTALVLTINDANQQSAKVNCMTWLAASGKPKFFGSRGSMVAKLKLKGIDGRAPPGVEPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCP3</accession>
    <name>A0A922LCP3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCP3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="8743" checksum="A3616BA31CDC0B9F" modified="2023-02-22" version="1">MLPFIVYICQWINHVYRRSFAGEDWIDTCQPSWPVVHKKWRRSLSLIALLFAAIKSLRNRLAREQSLIIWSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HGQ3</accession>
    <name>A0A922HGQ3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Solute-binding protein family 3/N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_014124</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HGQ3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052192">
        <property type="entry name" value="Insect_Ionotropic_Sensory_Rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643">
        <property type="entry name" value="IONOTROPIC RECEPTOR 20A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42643:SF24">
        <property type="entry name" value="IONOTROPIC RECEPTOR 60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Solute-binding protein family 3/N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9493371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="456" mass="53430" checksum="9B3C3D756BD8F77F" modified="2023-02-22" version="1">MDNLANMEFSVEYTIYPPFIGLNEHGSTTTMKGVDFYLLIELSRQLNFTFRLINLTDNWYERLMANQSLVDIIIGGFHLNYERSKLYKNLYPYFMDQTSIMTRQSKNHESYQHDRLLDPFDDYIWLAILFSLILLPLWTLITVHCNSINSDSILDSCSIWLYILLKQNVLSRLKRESSPTIIVSAVWIWATFMLSNFYAGCLLSMISIPINNRIDSLQELSDYCQQEKNMVVLMENNTTTMKIVHMMADKPLFAPMIAHEQLVDQQTEAISLILDESMAKMNGKSYAFLQYYTILKIIQQSFSPIKHRLHVAKASEQSSIHTSPTCFLFRSQFSYVRQFDRITIQLFSSGIYQSWLDNEFRTARMYIFATTLIKKLSYRQDDGENNQNDDGNFNDDDDDDNDSFRHLTLSQLMICFHLYMMAMAMAILVAIVEFLWFKKKQKTKQKIVFVLIKLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HHK7</accession>
    <name>A0A922HHK7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HHK7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="47" mass="5318" checksum="252CA63626BAD7A5" modified="2023-02-22" version="1">MAKDMITVNLFIDMLMISKKAHNNNSVTHTSSKEKRRSSIGKKNPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HHM2</accession>
    <name>A0A922HHM2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HHM2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="10055" checksum="7F8797233B0C97C6" modified="2023-02-22" version="1">MTNPLLGDSYISQVKKTQGPKFIETKKDIQRNFHGKPFIYFHSWVDIFFGGQQNRTFPPFPFTALAWIRTFVVQMTFPQRKVNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HJL5</accession>
    <name>A0A922HJL5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HJL5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="9513" checksum="3DF9C11AB49D0135" modified="2023-02-22" version="1">MTSSVRFIDHRLIMTNNLIAAYEFGCNHPKQNHLLTLNGNGKNHVPDSRATGLLLFFFKRQTVEIIIVENLIVMSSVVAAAIAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKA2</accession>
    <name>A0A922HKA2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKA2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="104" mass="11948" checksum="45BF23F424F888D5" modified="2023-02-22" version="1">MNFVVVVVVVALKKILKFQNALDNKKNEIIINQSIIDRLISCDSLLLLLLLLFLLLLLWFLPSFSSPFFCLYFTLSTGYDIIIDYMFVCAFFCCCCCCCCCDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HL44</accession>
    <name>A0A922HL44_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_016710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000010">
        <property type="protein sequence ID" value="KAH9490512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HL44"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9490512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7665" checksum="513C343DBD13F1F8" modified="2023-02-22" version="1">MSICSILLLNLLRIKIKEKEGGGQLLSLTVYRYISLEMKKKSELMQQVRFDFYTWKSSILIFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HME0</accession>
    <name>A0A922HME0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MAN1A2</name>
        <name evidence="9" type="ORF">DERF_014166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HME0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF6">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE IA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9493418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="444" mass="50218" checksum="9B9BDF4E0516026F" modified="2023-02-22" version="1">MAIGHNSASPLLSSTQQRLSPPPTTMMMMIHPRSVLRIREKYLLLAIIIIFMVISLIGMAYLPELKTSKVYLQYIKPADSLGPQLLGLIPPNDNDDNFNEIGGMQMVNDGHNNNYQQQQQTAILPPPPRGRFDDEKRLSEKIQQHFSQQQKTVIPKPNIPKSSPTSSPIVQSNSLDNHHDNVNNQHLVALYEPIRRQSNWTRIQLPNGEDGDPEIRKKRDKIKQMMIVAWDSYKKYAWGENELKPIKKTGHAPGVFGKTKLGATIVDGMDTLYIMGLMDRFEDGRQWIAENLDFNNIGSEISVFETIIRYVGGLLTCYAFTKDEMFLQKAVNITQRMLPAFDTPTGLPHALIKPALGTSRNYAWASQSNSILSEVGTLSLEFYYLTALTGDQIYYNKIDRIQTILDSLPKPNGLYPNYINPKTGKFGQKHISLGALGDSFYEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNB6</accession>
    <name>A0A922HNB6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 134-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_013856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNB6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026321">
        <property type="entry name" value="CC134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14735">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14735:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15002">
        <property type="entry name" value="ERK-JNK_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037365135" description="Coiled-coil domain-containing protein 134-like" evidence="2">
        <location>
            <begin position="24"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="28426" checksum="9DCDC6B2E0B1F730" modified="2023-02-22" version="1">MLFMYFPLLSTIISFIIIAIVSSSTITLSDNNNNNDDNGEINFNLSTKENIELYFRIKRKQQLNAVQTLLNYDRYDRQYQMVDKLFEKIFTIIDESQQQVINNSNYNIGDQLPLNQTEIVRNILQVIDNCAFFANIVLKLPDISRRLLDKRNGKSNDWAQSYRWCLNFTTNSNIVDDLSLKMFNLAAQQLNIVEKEADFLNPYEKKNQKSRTSSNSIIKDPVDKKKKNSKTKSSKGPRMSRIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNR5</accession>
    <name>A0A922HNR5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_013063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNR5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="252"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9497050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="549" mass="64951" checksum="33CB128799F119D6" modified="2023-02-22" version="1">MSLTTEEKQRLWHLFQACDTDSDGLVNQNDVRLLSSRSEFSDYNIEEIIDIFNTVNNDNDENCIMTFEDFIEKKLAHERLSQMSETTSISSGFTNTSTDESITDAAAIEYGKRYFNHRHHRQRQYDDNLNKYKNNLRFCDEIDSTLSKSMDNLQLDDGGVVDFHGNSDAITRRVFTAIPMGRKNHHHHHQHRNIITDHRAAAAALAANKFIVDINRFKSNKYLLPEEIERFDMSDDAKKKFELIRQDYFNCLNELSEENENICEELDRTRKERNYLREKIDILREEYGENLRKHREQWLCERQKLEQKITNLETYVTKIQHQQTSISSWPLMMMTNNPLLSDVINDNNPNESAQDYLYSENFKLHQLANKISELALFLSEILSNLRKSEIDIMVANYRAAGIVKNVTNPLHRNDIDEENDIMQCYERAMVNRSMIEREAIDFVRNIDKEILVQYLSPLEFQKLFNKNNNNRQSTTSTTTMDFQEFQNILSDLLIKLKDDLRNVNKTLDHHHHHHHHIQHNAQNDEQNDKLSIDTYSTYLQQHDYNNYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNZ0</accession>
    <name>A0A922HNZ0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_011968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNZ0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000011">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="10">
        <location>
            <begin position="108"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9501099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="360" mass="40362" checksum="E8B5BA7A2064BE9A" modified="2023-02-22" version="1">MNSNKSIGLLAKYMAIKQPENYVQTMYVWIDGHQNIRAKTRTLNFVPKSVTELPIWTTDGHSTYITETNAEIYLSPIRMYNDPFRGGNNKLIFCETLYEDFTATQSNTRHSCNAVMDMAADQEPWFGIEQEYSLLDGTDRNKPLGWPTGGFPGPQGPYYCGVGANRVFGRDIVEAHYRACMYSGVKIAGENAEVMPSQWEFQVGPCKGISIGDDLWMARFLLHRVAEDFHVAVTFDPKLIPGDWNGAGAHTNFSTKAMREKGGLAEIEAACKRLEKNHAKHIVKYDPSGGADNARRLTGKHETSSMDKFTYGVANRGASVRIPRQVADDGYGYLEDRRPASNMDPYVVCEQLVRTICLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQH8</accession>
    <name>A0A922HQH8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09077">
        <property type="entry name" value="R1-I-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="605"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9502140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1284" mass="147339" checksum="3A90624F6D5DEBB7" modified="2023-02-22" version="1">MGGKIILDYSMVHVEDMSPLRQCYRCYGFNHKAEKCQLKPEEQLCFHCGGRHNYNICPNQHCPPRCANCMKTGVKENINHNSVSKSCPDRICVAQINCNKSPSALTQFLKFCDERNIDIAIISEPPLRNNLPSINKKFNPMYAINSNRPTTNNRRVTRRSSRINQSTSTSQQSNSDQQQPVRACIITFNPALPSIIISHLSNTDYIVANINDIIIASVYCEPNTSINDTLNCITQTVNHANNKKCIIAGDFNAKSLYWGSDTTDDRGQEIMSTIAHLNLNILNEGNKPTFDTVRGQRRILSFIDLSLVNNNIIDHIYDWKVHDNVHLSDHRPITFIITDQYINNQYDRSTTRWNTSNIDWNSWSTNIEQQLDDHNITPAIINNINDHNELDIVVIRITNFIQHACDQHCGKYRNKRTRPAKWTNNQSLKDIINKQKSIYRKIRRCHNPFAIERLKNEYLIARQQYRDLAQSLKDDEFNRYLNGYGPENCYQKVCRLLKNNDNMVARTIEGTYNPIDSTTKLVASLFPDDDFNDNDEQQVIRQHTNKWLSKNKSSNGIPPVSILELNNVVHKFQDGKAPGFDGISPKIVKSFWLFFPDIMLAIYNGCLRLNYVPYLWKSSIIRILPKPGRDDYSKTNAYRPIGLISVLGKVLERIMSIRITNHLINNGHMSHHQYGFMAGKSTDHALLNLHNDIDTAISKFKHVCLISLDIRGAFDHTWHPFVIDQMIKYRTPKYLVQLINAYQNNRRITVSYGGVTCNKTTNRGTVQGSILGPLMWNLVVNDLLCKNFGFDVKIQAYADDVTMVVACDCINYMSIKINKILEMAACWGRKCKLTFSESKTKIMYVSKRIARPIYSPVRMNGSVIDPVKEIKILGIIFDHKLDYRPHIKHVVSKATRVNKSITGIARKSYGLSPAVLRMIYHSITEPILSYGGIVTNKATKYQHIHKIFRQLVTPIAQQATKAYRTSSFISVTALADFPPIELYINFRATVATARVTGKYLYNDQQVQVDINDNHNDDPSKRIATIIREPSVLPPTRIIIKSIKTARGIGSAYMIFSSTNITRINHFRLPLYCTIQQADLFTISKVFNMIQENHIHHTVYIVTNNISTAQHIGRRDRKNRQRLANELIDMALTNVIVAWNKIDKNEQWYQKLKIYAKRTANNRTREYDYQRMPLKTDLAPTSNSCVQMYMMPGNLYRSSTNMSHRLSPVTANSARIWPNLEYQTIKNVAVASDINYRFTGDIHHDQFIDSTYGHCPGIDHNATLRAHHAQQRMADLRDSAKPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQV1</accession>
    <name>A0A922HQV1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">IARS2</name>
        <name evidence="11" type="ORF">DERF_010730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQV1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="9">
        <location>
            <begin position="69"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="10">
        <location>
            <begin position="749"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9505968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1030" mass="120838" checksum="947570D294F00D1E" modified="2023-02-22" version="1">MFTYHTESSIIIRLLFRIIRINHRRFVLSSQCLNKSYTQTLNLPQSNFPMKHSRKLELNLEQQNVKFEDLFGISSQQRKCGKFLLHDGPPYANGDAHFGHAINRILKDIINKRKLLENFYVDFRPGWDCHGLPIELKAIPNNSDSRRLNPLEIRDRARRLAFNAIDRQRQAFNQWFLSANWSGIYRTMDLEYSIRELHAFYDMYRKGLIFRDRMPVYWSPSTRTALAEAELQYQTDHLSRAAFIRYPVVDQHYDALIWTTTPWTLLANEAIAFGERMNYCLIRIDGDNNQRPLLIARENLVTIQEMFKDCRIQIVQESISEFQNFRYQDPINGQCKSFLPSTLVTSSKGTGLIHIAPNHGQEDFKLMRQFFCKQPNSDNNHLMSKESIVDDDGRLRLPNNGGQSISIIDDNQASKYVLQNLLPKECVLYEHDYLHSYPYDWRSSKPVIIKPSDQWFLNMDELRDKCLAALSDVRLYPELLRKEMINQLSTRPNWCLSRQRKYGVPIPVFFDRKTTLPVLNDEIFQTLMKKFIQEGSLDIWWQQSPSELLAECPDRSLDLVNLEKSEDILDIWFDSGCSWLAVLGPDEIADLYLEGVDQIRGWFQSSLITSVALRGHAPYRSIIIHGFALDRDGYKMSKSLGNVINPMDIVNGNAFESNQQQTPTKKRKNSGDCGVDGLRLWIARNACTHNDVHVDLKEFQDDILTILNRFRNTYRFILGYLTKYSPSDHSFLIDYNNHHHHQSLPLIDQHLLYQTWIFDQKARKCYNEYRLGDLIEMMIHFFNYEFSTFYLSRIKDRLYCDSTESMDVRSIMTVLYYVYHTVGFHMAPILPHLIIECQQYWPFVHQAVIGNNNNNRMMKENLEQSELLLKQFQFIQSIIACINEWATSKHRLIDLDCHLSISANHPNVREMFATFQRFQPESSINDDGMECRSDLVECLQVARVSYGIDDNDKSTVNDQYYHGECLELRDKIPSSSNTAIESNHNGCQLRIYLKQTKNHQCPRCRRFTVINVHQNNLCLRCNFQMLHHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRH2</accession>
    <name>A0A922HRH2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9500999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRH2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9500999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8936" checksum="47BEBCA3AEFAB109" modified="2023-02-22" version="1">MLTRYLKTCDVHDLSIYHLSNEDNHNHKRSTSNKMNEIFYFCMNQDDDDFIKTIGNNDTRHEMKQLTLNKTKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRZ5</accession>
    <name>A0A922HRZ5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Myo20</name>
        <name evidence="9" type="ORF">DERF_010918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRZ5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF498">
        <property type="entry name" value="DACHS, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="85"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="916"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9506176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1100" mass="125277" checksum="82869CAB549695B2" modified="2023-02-22" version="1">MATAAALGVNKVFILDRYFAELNKYWQNECLHQQDKPKSNYNYNPYQQQQQQQQQQQPYKSNVNVGDRKLIINNHHHYHQSSTDNINDLIHLEAPITEDSLIRSLHTRFLSNEYFTNIGPVLIALNPYRELNNPLTLDSAHRNDNCYALYRIVHEAVRQQTETGYPQVIILSGISGSGKTYASMTILRQLFNLVGGGPETDAFKHLAAAFTVLRSLGSACTGENTESSRIGNFIEVQITDGAIYRTKIHCYFLDQSRVVKTIVNGGAERNYHIFYQMLLGLSLNEKTKLYLDGYNVDDFRYLNNDDNSDHHNHHNGLNSQSIQNHVNRFEAWKSCLSVLGIPFMDVARVLAAILLLGNIQFDNGGGGGVGQMIVDQQTDGLSFNKKELHAVASLLGVSTAQLHKGLAQRTYCSRDKGQILVSTRNAESFYVTRDSLAKALYTRTVATIIRRANSSKRLTSTCGTASSESNDSTHNNNHHHQQHLETASSHHAASSIGSACGKSYKSMAILQNAIRYSSMEGFIGILDMFGFEDARPSRLEQLCINLCAETMQHFYNTHIFKSSIESCRDEGIKPDLEIDYVDNVPCIDLISSLRTGLFSLIDYESINNGTAESIVAKQSSLHGSNSRYLEMTNLYENDPTLRLRSFGIRHFCGNVIYDTSDFIESNSDRLPDDVVAIFHKSQCSFGFASHLFGAELRCLKNRGTQPLGIHFRISPIHTPSMMTPQSDTNSIEPTTTFTQDFHNRLDNLLRILVHARPHFIRCIKINDCEQCDHFDRFTIMRQIRALQVLETVNLMAEGLPHRMRFKAFISRYRLLVHSSYVRQKEDTMLDDCRVILDHFDQIHRLNSSNTNRATAALTSWTLGRKHVFLSESARQQLEIARNGRRNAAATTIQALWHGHRLRRQWPYIKQVQMQQQQQQQRRCYQKPLDHHHQANHKVSRPPRPQPISFSTPPLSLTSEPQTLNLTGSNHIKSMNMYDFNLIKQTCLLLGIDPDTPPPVPSSRLYTVMNNQKFSFPQTRSLRMDFIDPMNHLKISKGQKVIVLGFSPYKRGCFTVEYSKGLRFDIPQHLVEQQPEFNVSNTITTHQSHHNHRQNYLGFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS30</accession>
    <name>A0A922HS30_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bax inhibitor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMBIM6</name>
        <name evidence="7" type="ORF">DERF_012542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS30"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034620">
        <property type="term" value="P:cellular response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033119">
        <property type="term" value="P:negative regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10430">
        <property type="entry name" value="BI-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF32">
        <property type="entry name" value="BAX INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9501718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="237" mass="26988" checksum="153E37CB37C168BC" modified="2023-02-22" version="1">MNAFDTFMSSLDRRLEPQVQTHLKKVYSTLAISVLSASIGGYVHLYTSLSNVIGGFLNFIFMTGLLIALYSTPDNGKNQPLRLNYLLGFSFFSGFGLGSLIEHSLYINPSILPTAFMATALIFACFTISAIYGDRRKTLFYGGILFSGLSLLTYMSLINLFFRSQLMFKAYVYIAFAIMCAFVIYDTAFIIEKRLRGDTDYIGHSILLFMDLISIFRHLLILLTEKERNDRRKRNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HS52</accession>
    <name>A0A922HS52_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Semaphorin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Sema-2a_1</name>
        <name evidence="1" type="ORF">DERF_011050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HS52"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7365" checksum="9CB3A9B54BD35A68" modified="2023-02-22" version="1">MDIHSSGAFIVITNIDSDSIIICTDIYSHISFDHIREFSCGHLYYRTLYIDPRRELLYIGAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSW0</accession>
    <name>A0A922HSW0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_011796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSW0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9507093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="257" mass="29432" checksum="BD373193FB40AECE" modified="2023-02-22" version="1">MRPTIEQRSNNDDEGGGGGGGDGSNRHLYDDNSSPKLRQNSIDPLLINNGNNNKQRNNILSSFRFQLPPLSALLRPSSSSTTHHHHCHRQHHLNRDYQPNDNNNKLSSCKSSSSSSSLSSMAMIITFFIMIIIIIATISFNSFNHLRNRIDQLEQKYSLLESRIISNHQWQPQSIDDDDDDDNSIVAQESFDQLISDIIDEWQLRQHKNEIDFIIEDDNDIDAAAADDDTKQKLKKFHNRFEQLVQMVSTDCFSFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HT63</accession>
    <name>A0A922HT63_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_010585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HT63"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13952">
        <property type="entry name" value="7tm_classB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="682"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="397"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9505814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="746" mass="86588" checksum="1533455458DE9BDA" modified="2023-02-22" version="1">MISAHHNHNDIIIIDDDDDDHHHVMTNISELFNQNIIDTLSNEAPLSLDFHVKFPSSFAVLVNYGVHGHKTKLYSSWIHNDRCKTNEIWDPFNNQCRRLYCRDGNHKFQDDNCVYNKDDPKPVIEFLDSLSKFINITLDFSTIKRIDKNWIVHNGDNIINEFRNKFAAKWGMNMNHLVNISIEYLHENSLSINFLILDNRKNIIIFNNLSHRIIFNQSEQYELQNIWMTAVAIHSIVSELKNFCLNITDMPLWYWNSEFAFITRDDQTYLYVNGTGRLYQTGQYTGSILYVGDVNDMDAMNHHMDDDNDDTIESMAKFSTNAVVCEQTLIDYDCPRILLSRDEYEFINGIDLYSHNIHYEHYELSDNNSIYVCIKNSTKSYDYYYDIYAKNLDTMIESILSTTLMFISIIMLTLLLITFIRFDQIRRSINGFNSINLAISLEMMQLLFLSNQFIQNCRIVAVLFHFFILSTISWSSVIAYEMYRVFITTKLVTRTLSNRSQNKIRLRYGLVGYISTFSIIIVANVGDIFNLEPIKGDYGRLELTEVCWMRRTRATIYYFIIPATVAIIYNLLLYVRIVCNIRHDLKSISSLRRITRISSSSSSSSSTHATKSSSSSSTSNSNRMTISVISSDFYDYEKQQQKQKRQQSLSSTTSLISSPSSSPLSSTSRTNTKQFFKNQTSLYVKLGVPLGFTWIIALILIIISQDVKNLILTRIISYVFIIANTSQGIVLFLSHGVYRKLFKRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HTW3</accession>
    <name>A0A922HTW3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_009389</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HTW3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF268">
        <property type="entry name" value="NEUROGENIC PROTEIN BIG BRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9510890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="191" mass="21362" checksum="047D78458F8E90D4" modified="2023-02-22" version="1">MAASTSHKIGGQLHTTESMLLHLLSRLDVARQRAQQARRKRFGRHEPISLATMRYELRTFDLWRSIIAECLASFLYVFLLCATHLTWTGSNFIFGSSTPNWLIIALCSGFTMATLIQCFGHISGGHINPAVTISFLFTKRISPLRAFMYILAHCTGAIAGAALLYGLNHNNNNHPRTPPTTLITILIQKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUY8</accession>
    <name>A0A922HUY8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_011650</name>
        <name evidence="2" type="ORF">HUG17_10051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000003">
        <property type="protein sequence ID" value="KAH7643360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUY8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7643360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="481" mass="57982" checksum="D041233B7490B48C" modified="2023-02-22" version="1">MLNKLRFYDQIRQLIIDDNNEKHWRLYRHEMIILLIEFIRIIGYLFICFKDISLLETLASYDPTVKLIFGNVLHSNMTLHYYQHKIENCRVTALTLAIGILYIIQSQYVIYFNDYRLIGFTSVYDFTVRNMDLYRSCLLFNHHRNQTDDNHWTNRLSFWSFIRSINHHNSNLWQIINIHYLCKQLQLQINFKRFKRIRMPIIPYISGEHKILLVLSVLIIHDYSIITHLICFIVVMNFNVRSFIHHLMIDGDSTLFITFVCIDLVNHFYVCHILVRNSIIYLNMATISQAYLLKRLRFLNHLMFRISTKQLPNKYGLNEFLFQQFRRQLTYICSMIHNSNHTIWANVILFALISNLPINIMATYRILYRPMNMQSLMLHILFVNVQILTIILTLFPMAEQNRLMHRSKRYMPRMQMSLERSNQIGIKIKTLEMYERLTSSKQQFGFSIGRIHIINHKYFFEILMSYVALMLMTFEFFSKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV05</accession>
    <name>A0A922HV05_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV05"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="77" mass="9199" checksum="56A2955A17F80452" modified="2023-02-22" version="1">MRKPKKNAIIEPNKYNLILQTNKYIIPKSGKKIQIPPNTNHRRNCLNLINDDDRKLFRVTRLFIGTDIETNDNYLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV23</accession>
    <name>A0A922HV23_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_010016</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV23"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Nuclear receptor subfamily 2 group E member"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="50"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <end position="256"/>
        </location>
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            <end position="432"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="749"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="388"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
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            <begin position="694"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9511565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="785" mass="85245" checksum="0176CB6BED37E094" modified="2023-02-22" version="1">MDIDSCSDSRSTSPIIITGNNGNHNNSSSSSLILASQQQNSTTSGRILLNIPCKVCHDYSSGKHYGIFACDGCAGFFKRSIRRNRQYICKARGSSANRCLVDKTHRNQCRACRLKKCLREGMNKDAVQEERGPRNSTLRRQVALNMCAQSSSYAAAAALAAAAYAGHHHSHSHSHPHHHNHPLSSHTTTFPYSQSSSSSSTSTAATVPVAQTFPFPSTISSTPSTGSAFGPPLPPLPPPPTSSSAQNFPLIPYGHHPSTLINQHPMAKTTISGTFDPYIRFRATSMNNQNLTTNHHNNNHDNDDCQSQNSKNKLNQKIIPRSDQDDDDDDDGNHGDLDENESNDDDNGNDNKKLKQQKNQRSRKSMKNSNNVNKHETNNIILDHHHGSLSSSSSSSSSSCLSSRSSSLSPSSKNTEIDTVTNNNNNNSTMINNNYHHTPLSINSDHHQYYNSITNYYHRILFDTLAANTNLRMAKQSSTTEEFLSSSSSSNHNNGSSMILPPPPPPPLPPSQSSNINNFDHFLFNLYQNRHHHSLFHQNHSHPFSMINNTQPTTEAVPTTTTTTMAAQRSTILQNNNFLYPLPPPPLPPPLPTPPQSSLPLITSTNNYLQNLYHIHPYTAASVSAAAAAAAFTLPPPPPLSLLPSTAVSLPSITNTSTSSSLSIPVISTSKTSETTTTTTPPPPMINPKSIHKQQQQPDEQFNNQTNNDNNNGDDDKTTTLLFQNFPWFTAAAAAAAAAAAAAAAAAATTTTTTTKNIGNKSKLDDSGTTTTSTSDHQRLSIQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HVX7</accession>
    <name>A0A922HVX7_DERFA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
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            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HVX7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6191" checksum="BE058E8E64E82BF4" modified="2023-02-22" version="1">MNGISSHFSSIARLTSSGTARILLNPRRNTSDTRLAPQRIAAVAQSNAVSPAPNTITCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW44</accession>
    <name>A0A922HW44_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
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            <taxon>Arachnida</taxon>
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            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW44"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6689" checksum="ABFD711EE45AA0EB" modified="2023-02-22" version="1">MIDIDCIVLFIELAYEVYKQNENVLLSNKTLSDSYSGFDTVSDYDGDTLLFVNSGQFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HX61</accession>
    <name>A0A922HX61_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_010491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HX61"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9512084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="309" mass="35860" checksum="D0EB352B6274C9A1" modified="2023-02-22" version="1">MGNQSVVRNNNNNEHKEESSSSNELIDLMIEFHSNRSKADECLNEYFKFLKKTNDEFLEKLRNIQMKNNNNNNEMIDGRILNNQQSSYVAMSSSNKTIPTTTYEKNESRQSKSTTSIYRHMDRNSMANNNNPIENVRSQSNQQKQQQQQQQQQTHSFVRQTTTTKTSSNQTAISNNDNNNNGLKRKSGHQNVVPNDNNDIRLKKTCPPKIPAQQTIVIANNLKMNDKNDSIVVVDDDDDDDDYENSRSSAHIPLYRFRCSHKGCQYVTNKYWQNHQRHHDGEKMYQCPKCSANFLSEPGLHGHFFRNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXN5</accession>
    <name>A0A922HXN5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXN5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7603" checksum="214C4A22ECF2274E" modified="2023-02-22" version="1">MIHCQKESENRNRNNNNKIDNPKLVIHPFSIYFVDFITTCQNQIDFLSAEKKTENFNFARVNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXV0</accession>
    <name>A0A922HXV0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9507077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXV0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9507077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7478" checksum="3C0BE8578E5845A3" modified="2023-02-22" version="1">MASGCFVCNNNTRFEFVKIVQLRPHEIGFAVFFFLTRNKFVQCNGYGYNNDDDDNNKFDRDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HYL3</accession>
    <name>A0A922HYL3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HYL3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="94" mass="10737" checksum="1414E85A7448804D" modified="2023-02-22" version="1">MKKKYYNLHYLIGQSVFFSLPIPIPQSAAAVSSNNLDNYYSKLSPGDCNQINVVDDEDNDVSRLDLVKIHKYNKITDNEKIIHDHGHGSFVFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ23</accession>
    <name>A0A922HZ23_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear receptor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_007279</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ23"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050200">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48092">
        <property type="entry name" value="KNIRPS-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9516544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="364" mass="39492" checksum="5E32981CA0E23E6E" modified="2023-02-22" version="1">MTSFFGRTYNNLSALGECKNNGECVINKKNRTSCKSCRLKKCLMVGMSKSGSRYGRRSNWFKIHCLIQDQQEMSNRMTEQGLSLTGQVKNGSSDVDMKIGDSKDFLAKYKENELRNTSTVVNNFNELTAAAAAAAVAQNNNNNNNSSHSHRISPRLAASPSTTNSEGSLGGHRSVSSPFHPGLFDSAKMANTFTNPYLPAAAAAAAAAAQQQQQQQAINSLPFNANDFQKEFNNLASRFNPGTIPLAPISPLSPLNAAVSRLFLQNNNAANAFSVLGKRFSELQKLQNEQLLLNQAASQFLNPTATALQQAVLKQQPGLNSSIGTVVPSQKDLVEEMTNGLREFYGDTPEQDGPIDLSPLQLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZC2</accession>
    <name>A0A922HZC2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZC2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9512044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="116" mass="13193" checksum="A20C7BD11E93BEE6" modified="2023-02-22" version="1">MKKTRRKKHRRPEQNRQQIQQSMTMTFNDYRSIIIIFITIIVLLLQQQSLLSTANASNIIIMSNSSSSSSSSPLLSSASALMSSSSHYSVQMWISDLSNQSILNCFFFVSTVTMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZS1</accession>
    <name>A0A922HZS1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZS1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="174" mass="20210" checksum="9A4CDB59A2ED5409" modified="2023-02-22" version="1">MFIVKKVYGLTPRTAHLLLNVYFCYNHVWLPRMERITQFQYMERELPSFVALSAITNTPPLELHIEYVANVTLARITGKYRHDDDEIILDKCCYGIGSASGYFDGQLIIRQRTDFQHFVQFLQAICISFIWQSIGSSRTIITHGITIISTIWGNNAYYHNRKNRIAKSIIESTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I020</accession>
    <name>A0A922I020_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I020"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="305" mass="35290" checksum="46EBE4B11741472B" modified="2023-02-22" version="1">MNIISDELKKLAMPLPHKENDGVAVRLSHHVFLFDFWKIDILKSSMSKKKNNISRSIKVSMDQLMSWIENEGIKDEFIIPAYGKLIDKLNDFVHSYGSFSMDFDVFQIIQNKIESIADSSEISSDLRILVTEKFNISKQITPKFLSIKKRRKFDQRSSITKAYNQIRSKQKSLTFCCGKLFKTHTNMHRHIVKTHPDVIIDGNNPQEESTDTSQIQGTSLEYSMFSDIEQSTSSDDVSVKVEIETDPEFCDVLVKADTETDSELNDVLMVSDNEMAQDRMMLKRLIAKQSSNQMIFRWWTILKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1S1</accession>
    <name>A0A922I1S1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">DERF_004592</name>
        <name evidence="25" type="ORF">HUG17_0647</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">Derf</strain>
            <tissue evidence="26">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">JKM2019</strain>
            <tissue evidence="25">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="25" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="25">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="26" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">Derf</strain>
            <tissue evidence="26">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001512">
        <property type="entry name" value="Receptor tyrosine-protein kinase erbB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF564">
        <property type="entry name" value="MACROPHAGE-STIMULATING PROTEIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 25" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 22" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 21 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324697" description="receptor protein-tyrosine kinase" evidence="22">
        <location>
            <begin position="29"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1149"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1301"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="24">
        <location>
            <begin position="73"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="1240"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1527"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1622"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1723"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1827"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1631"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1644"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1678"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="1830"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KAH7645109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KAH9520912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1848" mass="213915" checksum="FA678D7BFE9ACBED" modified="2023-02-22" version="1">MAILNHRLRKIFILYLLLHMTIDPGIDCWSFEKLNFFRPRQPSSLNLMKPEKMKTTTPTNKQLSYIDSENIFHFVLNPNNDTIKNQQFHLINFTISDQSSPSFYTMYRTNENEFFIGSNNIVYRVDLIENTADDDNDENEFKFHLFGQLSLGPYEINRQCMQTIDNNRTNRQQLIDNQIIQIFQFHSTIFVCGTNRCGLCDGVRKDFSKTKIYASSIKNFSGECQVDLQSTTQLPSSRIKMAMKMDNNNAATNYDDYLKPINFISTLNGHHGSLIFFGKHDDIDVLYTAYSNDGRDKSLQLPFITARVLNNNGFHYVRHEGNECSRIKLESQDYQFNFIAGFNYDNFVYFLFMEHHESSNNQQLRLGRLCENDPHPFFSYMEITLKCNDFYSSRVAHLSLALNGDEYLGFKLNSSQEQDAQLLISFNKNSEHDGESLVCQFSMAKISEHFLDGFNRCTLNGRGKWLRKLTNYDTVQCKETTFNNKLSGEQNQCPYTNANRYIDYDIPLDGQPLINIKKDHITSLGSIFINNQYQHLFVGTTNGFLYKFLRKLNKNHELKFNYRLKLDESLLSLQQVSFDIETATFYLLSSHHLYRYPIVSCSLYKTCSTCFQSKSYHTELCYWHNNQCVLKKSIDNNKNLQQPTCDPIVQSFEPKQGPIQGGSIVKFYGKNFGESKSTPNSFIQIKIGHIPCNIIDGNDTFVQCQIARNDSNHEHDATILFYARDMLDFSRRQFLINGEIELNEKFRFSSPIVCGIHPTFGPFAGGTQLLLLGKYLDIGSNVSLKLGDQQCKTLTRGHRYFICDTMPLNNHSVNQLLHPEHKTIQFKIDNFDTNLGKNRDSFSLQSPELIFDNKINNIDTCEDLQLFSKQSNVKPRQRRRRRRIHRNQNQFLMESSSLVDRFLFRFHKLIQENQTIEFDKIFQYKRNPNHIKLDDTNAGGFYSDYSTLNFDGTNFQSILYPELELIFKSIDDSSSSSSSFNLNQKTKHVFTQCNYQHPTKSRSSYLSCYIPPLNSLNVDDSYLPLQAQYILHLDDNIQSNGSVIFHPDPKFYPLNMTTVSESNRSLVLLGENLSTDFPIKIIINGYYHCYPKKRGINHIYCDVDIAGQELDDLIDIPMNVTVTVGSNTTRLGEMVFKPYVSAFNKSKAMMPYIVIGFLIMLTTLLIGLCFIWLYVRDHVKNEKSNFNNNTGYNLIERPLTMSEIETQNLLDESFEEIENGLELREEIQKKNLILIDINRLKLLEPLGEGNYGFVFRGQLDDDENNVVAVKTVKDPKFKCFLLDEVKLMKDFRHQNVMSLKYVTIICPIPPLYSAPSLALVFPLMHRGDLRSYVSDDSNLPCLRDLINYSTQIASGMDYLSQQNFVHRDLAARNCLLDKNNRVKIGDFGLSRRYQEDKTYYRATNNETQLPLRWMALESLTDNCFTTKSDVWSYGVLVWELYTRGRVPYQDEISKSAPQPDTLIRYLSNGYRLPKPWIPDIFWIVNMRCWLPEPEARPTFAEIVDNLCEITRLFIAKRANMDQNCNKLSPPLNGTTTTTTLNSTNPSQFFNNPNQQSPSSTVFTLNTQFNNNNNNNFSLNFEDPFIKNRLTNIFESLRNEYRSTKQLLDDDLYRARYDYCNLKQNDDGHGNFPSNNKNTLRSNHNHQQQRQQSINSGGRQQNSSIQQSSFHHQPEDYDQQITEPSSLQHQQQRQPMHDPLFQKIFGANTTDNENNSRIQSMMISNENDQSPPPYLEATSLPPNTPTTMMMMANQFDYSIPRPQSLPPPPQRQQQQQQQQETIFSAQSPFTTINNNQSNSINENDNNPMMVMKQESDHNKQMIMMRNEFSSRGGGSVGGGGDTLSPTNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2J3</accession>
    <name>A0A922I2J3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Abscission/NoCut checkpoint regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ZFYVE19</name>
        <name evidence="3" type="ORF">DERF_008873</name>
        <name evidence="2" type="ORF">HUG17_4774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2J3"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009838">
        <property type="term" value="P:abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044878">
        <property type="term" value="P:mitotic cytokinesis checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19817">
        <property type="entry name" value="Bbox1_ANCHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044553">
        <property type="entry name" value="Bbox1_ANCHR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9518284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="227" mass="26706" checksum="66EAFF95086DD8CD" modified="2023-02-22" version="1">MDEEIEQRLRGLDETVNELARKNKSKELQKEIELRLAKLNERDPNFYSAQEPPVKLLSIKKHRTAVEEADDLLQQFMQEVSLDEKKNESLIVADKELEQRLEKLATEQAELSINKNRKNPMLKKFKQTGNLIHQLVMRRSLEIRERSLDDGNDDEIPDVIADDDEQLNEVINDDVDWCTTCNEDGVVRCIDCDMDIYCLDCFRELHRDRDMRGHRTQPYQSSQSQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2L8</accession>
    <name>A0A922I2L8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005012</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2L8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17347" checksum="B6D91DA9650F4F66" modified="2023-02-22" version="1">MWSKKITEFMMMMINASNYGQNDDGDIPPIHFKLDYLVKIFSLKNNSTAMDCFYESPIAYDNLIYPAKINLSVTNENDTCFQHQHYYHIYTDGSKFENYVGAAFVVFSVHENRIPFLRKMFRLDNRCSIYQAELLAVVEAINWVVDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2023-06-28" version="2" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3E7</accession>
    <name>A0A922I3E7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="10" mass="1234" checksum="6798E25046C7740B" modified="2023-02-22" version="1">MAERPQIYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3H3</accession>
    <name>A0A922I3H3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3H3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6839" checksum="C644500742627C7A" modified="2023-02-22" version="1" fragment="single">MARFRSYYAQEVLQGRRHLDIGIPVLWFDIVEMKPLLIDQVLTAVMTMMNAESMPVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I476</accession>
    <name>A0A922I476_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I476"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="43" mass="5490" checksum="F929C24F2021C06A" modified="2023-02-22" version="1">MEKKFDQQQQQQQQQQRNRIENSANKLDWPELWYFFPEFVTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4U5</accession>
    <name>A0A922I4U5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Grainyhead-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GRHL2_1</name>
        <name evidence="9" type="ORF">DERF_005197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4U5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="8">
        <location>
            <begin position="778"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9521552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1181" mass="127730" checksum="0B226F0DAC106F2F" modified="2023-02-22" version="1">MLNINGSSADIVQHLGGHHSHNNNNNNNHHHHHHHLYHNNNHHHMNNNNNNHHHQTNGSSTTSITSTTTPVSAITVPASATVQSLYDFYKIPVVVDGIGGVGGGGGGVGKTAGITLITSDGKNITDAAALQEMVWSAVPVSAVSTTDGVLQNATIVTTSGSLAATSAVTSSSSSSSSPSSTSTITTTTNNNQHNDDDHRQQQQQQELSSLNGHNNNNNIQSPQSSPLIVKLEQAKNHLIVTAAGNSLSSDNSGLVVNQNGTVTIAGSGGQQQESQPTTTNNNGQSQTIIVTTTPSQQQSQQQLQNGQQRTTASVLHGTELVHIKTEPTSTTGTILQQTNDNSVVHIKPESTTASTATTTVLQHVNEVVHIKNEPLDTLPPLSSPGQMVDVISANNVDHSRELEPSPPATVISLAPAQPYPPNNNNNNNNNATPTQLTFATSAYDLSGNGQYALQVNANTALAPQYAVTPTATAAARTTNGGTVYLTTDYITYREYYPTNANGIQPQQQPQQIIVTTNPAATAMTAGTATNTGDQQYHTVRQQLVTQQIPQVTIAGNNNYQTTANMVGETETSFLDRYLRQQQQQPVTTQATTTTSMVSNNNNGVGVTQQQPGTIAIQSLQPTTATTSTTNGVVNGYKSNTTAIHSCLTVDLPSPDSGIGDTTTATPRQETTTTTIPQIFEYTGLTAAQQTPTLLPVVTAAAATDLTSVAVVATPTVSSSSSAPSSVTSPTSIGSVANVTTPTAAGTPAAVTKSASRRSWHEYGRNSDIDKIQIPKLFSDIGFKYFLESPISTSQRREDDRVTYINKGQFYGITMEYINDPDKPLKNGTVKSIVMLVFREEKTQDEEVKAWQFWHSRQHSVKQRILDADTKNSSGIVGPIEEVAHNAIAFYWNPLEGQAKVNIAVQCLSTDFSNQKGVKGLPLHLQVDTFDDIREGSTPVHRGYCQIKVFCDKGAERKTRDEERRAAKRKMNATGNIVSDGRKKIEEMYHPTCDRSEFYSMSDLMKPPVLFTPSEDIDKITTGDINFYGHTSTDIGYDTDSGALPSISTNIPLTTLHPCERTDQSLVCDMPIACPPKKIKLERYPSLNDRVLLYAKQENEEVFHPLHLVPPTLVGLAWAIENKYKLEAKNIRNIYKRCKKGITVQMDDDMVKHYSHEDTVLLEVHQIDAETHDITLVEYDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4V5</accession>
    <name>A0A922I4V5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retinol dehydrogenase 11-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_005211</name>
        <name evidence="3" type="ORF">HUG17_3731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4V5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7639698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9521567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="388" mass="44024" checksum="5D462A1112AE6BAA" modified="2023-02-22" version="1">MAPPFINVPSSIQTFTPNTFSLMDNDDDDGSTYEIDHESKYQFKTSAIITCFHSLIDSNILFISLLLITIIISFTALYYVIIVRILLEKIRRDIDDDDIKGKTIIITGANQGIGAMVVRNLANRGARIILLCRDMDKAHEIVNDILMANPIAELSVHHIDLSSQASIRVCVNELLKLEPRIDCLINCASVAFIPGVEPTKSIDGYELHMAINYYGHFLLTFLLNERMKQTAKQYETIGKVINVVSILHRCGKIHMVNLNLDKSYTPFRAYSQSKLALMMAGREMAKQWKSSNIRVYNVDPGFSMTQSHYQNLYPACRKILTIFGWLIGFHSNTKAAEQIVRCVIDKQIVHQSGYYYRNGQHVTPSTRALDDRMAQNLWAHTITVCNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I524</accession>
    <name>A0A922I524_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I524"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="92" mass="11113" checksum="9E4188B9A48EB395" modified="2023-02-22" version="1">MMAMAIDDNNNKNNEKKSILTIMIIKHDDLRDDDKLPKKKNQILFILNNNNHQLDTFMIMMMIIKWLHFNAFYYDMMCIHNYHLTAILQQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5I7</accession>
    <name>A0A922I5I7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5I7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="90" mass="10177" checksum="E8949A87CB1597FB" modified="2023-02-22" version="1">MKKMFHTTKRILSISISLFVVVIIFIIIVVDASIGYKKFLKGLIVGALLSKGKGGGGGNYQDQHHYFYPVSYYPTYSDSYDDSYDSCSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6F3</accession>
    <name>A0A922I6F3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6F3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="79" mass="9054" checksum="D84196BAB8346A8D" modified="2023-02-22" version="1">MKVNYVKNCYYCFWIPTTTTVTNNDNTTILKSTSKEKVLKLVILYLHCLAPITHCICSNNNNTIDSTLIKSIRLNNNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6Q9</accession>
    <name>A0A922I6Q9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dfp2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_005362</name>
        <name evidence="3" type="ORF">HUG17_3605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6Q9"/>
    <dbReference type="OrthoDB" id="6492497at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324709" evidence="2">
        <location>
            <begin position="25"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7639572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9521730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="198" mass="21824" checksum="AC3A7E165D1ECE4F" modified="2023-02-22" version="1">MLFYNRFTYCLLAIAVIAIINVNAQGGFDAMDGQFKEGGSGRERIQAAVQTKHTVEMKPVDIPYEDIEPQVIEVEGGALPLEIHFKSSSSRIRVHQTHEAAGAGEVEQTSSEEEPHRLIHEVKKPIIQEVREIITPYRKVVQEIQPVMEEIHTIVAKGEARRNFDRTQTKTRGGRGSLASPSARAQSAGSSGSSTSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6Z1</accession>
    <name>A0A922I6Z1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GTF2F1</name>
        <name evidence="10" type="ORF">DERF_004830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6Z1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="202"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9521159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="498" mass="57361" checksum="BAA48E2362287CFB" modified="2023-02-22" version="1">MSSDQKEYIVRVPSDTKKQFHVMRFSSALNVDVTKLKNCKLEREIMFKEIKEQQEEELPEFGAGSEFGRKEKEEARRRKFERRKNKQNNSPWILKVGGKHGKKYRGIREGGVTENASYYVFFQASDGMFEAFPVNEWYNFTPFQRYKALSAEEAEEKFIKRDQILNFFQLRNMAKTKEGDKDDSSKKSQRKMKKEFKVSDMDDWYDMSENDDDNFSGDGNDDSDEDTKQRKSRKDKGKKDKRKIKKEDSDEEEPLEDSDEGDYDDKEVDYMSDESSSSESEEEKVGLKGVADESALRDLVVSEEDEEEEEGANKYENQEQNEDANKSIDSDKLKSNKLEKKTGGNDSSSESDFDSENSDIEEPKSALLIQPSKNLNKSSSISTPIPVATSTSSPNKDNNSSNNKSNGLKFKHKLENPMANEHSMAKKMKVKHDSGITEEAVRRYLIRKPMTAADLVQKFKNKTARKEKLTDLLAEILRKINPEIQNIKGKMYLSLKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I726</accession>
    <name>A0A922I726_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADP-ribosylation factor-like protein 6</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Adp ribosylation factor-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARL6</name>
        <name evidence="7" type="ORF">DERF_005530</name>
        <name evidence="6" type="ORF">HUG17_3486</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I726"/>
    <dbReference type="OrthoDB" id="442317at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="129"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7639453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9521916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="266" mass="30141" checksum="6B30484AD50076CB" modified="2023-02-22" version="1">MSSFFGRFLTILGLKRREANVLVVGLDNSGKSTILNYLKRKEDQVEEIVPTVGYTVERLSGIERNRSGIALTAFDMSGQGRYRNLWEHYYDSVEGIIFVVDSTDALRLVVARDELEMLLKHQQVVLDNKSRMNDKQNGVHDDGHDESNKNGPNHEDLSTDMNQSINNDRSTSSKQDIPILFFANKMDLKEALPTVKISQTLGLHQLPHKQWHVQSSNALTGDGVQEGIDWLLVQLANNKKLHNSNSNNNNNNNNNYNQSLKQQPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I743</accession>
    <name>A0A922I743_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_000319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I743"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9526219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="76" mass="9061" checksum="3D6F47B431D7DFF1" modified="2023-02-22" version="1">MPERHILTLFVRNHDDIATTTTSMAMFCQFYFDNIYALYGYNILERSLRSLIWTKLSNKLKIIATQFMFNDMGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I793</accession>
    <name>A0A922I793_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B-cell lymphoma 9 beta-catenin binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_004992</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7668649at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024670">
        <property type="entry name" value="BCL9_beta-catenin-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36911:SF3">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36911">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11502">
        <property type="entry name" value="BCL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B-cell lymphoma 9 beta-catenin binding" evidence="5">
        <location>
            <begin position="832"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="682"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="861"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1336"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1409"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="372"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="792"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="808"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="897"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="958"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1015"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1084"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1112"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1131"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1466"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1494"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1545"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1712"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1753"/>
            <end position="1783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9521324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1783" mass="188059" checksum="ECC70F297C1F94C4" modified="2023-02-22" version="1">MNILDKQSPTASSITTSTITTTTTTTLASSGAVAAASSSTATLTSVTNNNNNNNSGQQLSNNNNSNNNNNSGNSQNCAPGNGGNNHNNNVNNNNNNNGGGNGTTPLQPPPLPPLSQCSSATGGCSSVGQPSTPLTPSSSSSSQDCILSNNQLISSMSKTSVGSGGGGGGGQQGPSSVSSSCSAPHTPLDSLQASINSQSDPSSITTNSGIQRPTNVSTPSSVSFTNNNNTNSAPSTPASMIQGGGCPPSVGSQNNDNLSMTPMIGSPSLNQLTPTGEYTPVSSQSPFANSQQQQQQPNQTNSANTSTTSTQPNLLSSSPLSVHQHQQLSSNLDNQICNNTNNNNNGKNKTINNNGAGTNGGNSNPNKKHCNNRNNNNNANNNNPNGPNNLMSNNNNGIGIMGMGNNFPMNQQQQQPPPPMQPPHSSQMSMNPNSCMGGMALGPNNNNNNMSGMMMGCGSVDNKNQMNHFSSMTPPHNSLSNNNQMPCGGMPNGMSSSSTGPPPPPPGMVNGSISPFDVDCGPKTMSQFPKEFSPELWDGCGPPPPRMPSNCHPSMGGGPPPMNMPPSNMMNVGPNKNMCNMNPNMLPNTGPPPHASNMKTPPMDGGIGNIGGGGGGGGGGQFIQQQNQVFVFNTMMANNAADAVEQRRFPSIIHFHMNQPITKKFMEKNSIKLQSLNRQPNNSWMAGNIRQPRIRGPNASTNGMPPMRGNFASTTNPPCFSPYNHNPPPGPGPGGGGGGGGAGSPGPGQWNPNWPPSGPPPPNNHHHMSGSGNVPPPFSNDMKMGCGVNPMNAPPPMRQCGPPPPPQQYNSNNSGSNFNPQGYPMGCNEDDNLTPQQKQHRENKLAILANIQQKFLQQEANQNPNNRLGPPPPPQNAQSLGSNPDHFVPGMMDPMMTSGNSNQQSMMYPLHHSHPPPHHHQHHSDPQMSFKQENIDPHNHTMNPRGHAPPPGMNTSDMNFNPNFCPNPMMNNNSNNDPWLKSGSGSNFPPMIDETKPFTSTTTTTTTSNSRRKGSQQQQNANHLSPISQQGPINSPNQSCINQSPSNRVPPPPYNPSLHRSMSSPHPGSPAAMSLPSPRMASDSGRQTNYTPGSVRSGPSTPVVVDGPLINSPKSNSRANSSPGNSKKAKQQQQQQQQQQQQQQQTIDNDLNMFGAKSEHPLMPVPSPQQIDYINTFEGQELTIQKQPNAHFQETNDMMVSGGGGGNDLLNNDLFVNDFMCGPNQQSNNPPPPMSMNNPRFPSGPCNFDSRYQDNMRFNGGPMMDNYNRPSPHGMCGSQTGGPPQFNPNDPNSIRFPNCDMKSSRMSGSNGPDMGTFPPPSNSMCDIDFANSIPPINDGMSGSFSNGGGPPGPGGPNFNDSPSVDNNSINSLQSLQKMAPPFEVTGPNSKSGPMGVGAPTGMMAQPNQMMGQNQKGGRIPGNYDQPFGPGPGMSQIPPCSDLNDSNNYGGPPHMVQSANMPPMNYPQNSFSQSPNPSMPSNMMPGSDPQYGGSMHSSNGPFSPLPMNTPTHSMVDQNSSNGPSPIPPMMQPGPGSQGNFGPRMPPSSNVSRPMNPSNNHGQRYNSPNIQVKPDAPNTIQYLPSRPQGPTTTPPNRPPNLDFLQQSLNMGSNKSSGPPPPPNSYYPPNSTGSMAPNRPNMNFGGPRGPSLMRPQNMNTAAGPPVSGPPPQPGNMCAGNDMMFNRPPGSANHQMTNGPNRMPPPPPNANFGPNGPTPGPPPPVNGPIAPPGQKPGGNNGPVLHPDSFDKFDNDSAYAQQYHNFQQQLYATNTRNSANNPRMSSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7M3</accession>
    <name>A0A922I7M3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_006504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7M3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037893935" evidence="3">
        <location>
            <begin position="26"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9522950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="421" mass="48032" checksum="F0F4C48B28286EB0" modified="2023-02-22" version="1">MLLASKTSLILFLIGLLNQNRTSESLYPYKLSNNNNNHNPYYARSLTENLLASLAGMTSTTANNHLLNGHHYDKNSIIYTNQYVSDPFRLLTMKQMPFITAQSSPSSWMYQLPFATGSAQCDQSLMLEPEFHRCRSNAAVYWHQGLANPQYQQSSSSSSSSSSSSSSVSTKHTCCFLWDLVDCMEEAIRRRCSYSFDIFRRNRVDYVARIQSNPLCYNHLYGSFSCMQENWILLLAFIILAIFIAVTICVACWTLVCRKKWRNKNDKGSDYNANVLPTAIGGSSGYVDYDLERRDTQQQLNRSRRRSSPRTSTRRVSNGHGRNVESNTRIKHIDSDVDDNDDGVNMDQMSASHTQASPPFKDYEPPRRFHFHQHRSQSPPVAATTTRHHYSISNKHRTRSPSATDYSPRPTSVVSVRQIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8C3</accession>
    <name>A0A922I8C3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPS25</name>
        <name evidence="7" type="ORF">DERF_001298</name>
        <name evidence="6" type="ORF">HUG17_4502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8C3"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000166">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7641458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9527272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="136" mass="15182" checksum="12F6AC6114753693" modified="2023-02-22" version="1">MPPKQDKGKKDPKGGKSKKEGSGGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKFVKEVPSYKLITPSLVSERLKVRASLAKRALSELHGKGLIRLIEKHHSQMIFTRNTKADDAADVEEVEEQPTTKGRKGKQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8D1</accession>
    <name>A0A922I8D1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8D1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="179" mass="20283" checksum="0213D7ED52AE8F56" modified="2023-02-22" version="1" fragment="single">MTNYCLAVLNEQDEVTKENAVVWDHNITVDSVVKQLSLAVFFNLIMELFRDSDEQIETTTIIGKVINKASSTNSELVVLGWICHFLDSELVVLGGIDLNLNNFIEKIQFAMSKFFVLKNHIKLQRFISNTKIGRIITIHNTSDRNSKIIHIYFQALGQKNPSSILEHAMSPLRGHPSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8Q6</accession>
    <name>A0A922I8Q6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gamma-tubulin complex component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TUBGCP2</name>
        <name evidence="9" type="ORF">DERF_005677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="342"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="819"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="985"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="972"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="977"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9522074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1359" mass="155167" checksum="73DBDF45598E467C" modified="2023-02-22" version="1">MDHRRQQHQQQQQQQQPSNMNRKFNSHQQQRYSTLSSQSPTSSSTATIHQSSSSNMNKYELENSVSELFRLFNVSEAKNFNRETIAERFEKGLNRQSSKPFSIFYNRLSDNPKFVEQYNPLKCQNSREVDPFVRFMVRVREDKNMSNFMNNYNDIVQSKSKFCPNSTTKNNQISTQIYRRTNQTSPRVSRPSSATSALLNMVNQQDFNPLKYQMSAAEHSNNIVKSKTLGARSIEAKSPLRSLQTPKGGHNPSLLASPMITNVDSGQNGQDDTNDISFKSQTSTTVLNSKKTISNHQHNHNQSRKIPPYLSRDFHPCDWPKENDCFNTLGTYPVQEQEQLLLRDLLFVLIGIEGRFIRLLRSQDSSHYKLILDPSTDHFFAVTTQRILKICYHYSTIISFVESRVYGLVNQALVASIHQHLYDYNMTICQMEDSLMKNDLFLQKMFFILLPYFSTFALLKEICAKLYKNKSVGGAVLTLLHEKTKSIQGMDNNALELCLMLTKSAAIPYFDIMKTWIYYGEIGDPRKEFFIEDTHSHQSVGVMGGGTYYAGTSGNSHQNGRSATDGLNNSSSIQSQNQSHHHNDTDLVESDDEYDDDFGKFNDKYWDVRYRINSSKTPCFLRKYEQVIYKTGKYVSIINKVKQLFLKSSKVIPIPQSIFQQQNQQQQHQMHNLGATTTVGSSVLQSDAASSFVPKHYGSNAVMNTIGGGNSPFMFMNNPNANNNYYGHHQHHSTNPMMTDNTSFAYSMASSSSSNASNHSGGGGGAPAQPASTMAAIFTPKPEEIYYSFDESTYLAPIQSAYEEASSQLLHILVHESQLVETFNAVRHYMLLSMGDFIVHFMKFASKDLCKRTDSVVQHRLDSMMGMALGISVCHSDRQYLKDDPHVEFVGKSFLKQIYQIMKPFATQEDNSFNTSFANDPSPSSSYLLRCDEDAEDDDDDVALNRSIISSVIEDQEFNANDDSIDSIIRRPPRYLNNKNNSPNSKSMDNKSNTSTLKKKSIVMNEMNACESSKLFCYESLMLKFDVPFPLSLIFTQKSVVCYELLFRYIFLCRYAEMELEETWKDNILNVQLKRCDTLTLLNQLTNSSGKTDQQQDQTNHARLLAKSFKSIHKKAFALRYKMIAFVRNFHYFYAFEVIDPSFSQFISQITKRGSSLDSVIECHEKFLEHCFSSCFLTSLEITTIIIKIFTLCIELSHLLKDSIDAEDQSTMMESSCFFGQSLKSSNQSPTKPTTTSSSISKNLAREFDSAANSEVDEDLIHEKLNKLYFSNRIFGGLSDNHQTKVGGQTTTNTNRSFTIKDIIDKANTEFDSLVSQLLKKIYSDNCEYHMMFPFVARLDYNDFYRFQIMELKNNSFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9B2</accession>
    <name>A0A922I9B2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-glucosidase</fullName>
            <ecNumber evidence="2">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_000648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1027"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="518"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="631"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="834"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="835"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9526573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1283" mass="147901" checksum="7FD38F2078AD0F30" modified="2023-02-22" version="1">MNVTNNLDFVGGGGDDDDDIICIKSSKSSIQTKGVSFLEYVEVSGDNDCDDNNVNKCNINIENNGDDCNVQQTSIIRSSPSSIDMQQSSSSSSIHYHRSINNGQFHYEPLRPPAISSPLESISSTDNSNSSPSSLLSPLVSLDYHHHHHQHHNPHHLANINATMHNPQMTQQYDSNIVNNMIQDRPSVIYKPVRSLIQYWPESHPHIPLSLPQNQYDAHPLDQQQQQQINQSSLLLHQSSICDTQILSMNSNNNINNNNNNVPMLLDHLISKSSSSDSDTNDSGTRLISDSYNDLIISASDTITTATTTNTTTATTTTTTINNNQNNHHVYLTSMNQIDTIVENHEPESMNLSSSSTAMNENNPNDLWIQVQGDLSKNLREKYLQNQSANNLDSVTNNNNNNSSSNNNNNNNSSSNRRKKNFQKFRRIGFERFGFNCPLSHRMTRIIIWSSITVCLSITLLIIWFSFLRYHHHHHHGGLWWLPRWLFGSTTTTNHYYQTRRYQFDQDPYWYHGTTFYEIFPASFKDSDGDGYGDFMGIVERVDYLRSLGINAIRLNSIFAAFDYPRYYDNVLNFYDVDPHLGNFQSFFKMIQVLHSNQIRVILELNPTITSDEHPWSMNRTTEYENYYYHHHSRRKSATTNKKNVKVTPPPPPPAITTTMTQQKKKKTNTNDDDDVHHQHNYHHHHRRFDNLAANDNNGNDDDDDEGTPPGGRWLNWNNEAIPKHMLKVADFWLRYVDGLYLKNLEKIHVDFDGDDDNDNGNDNGDNIALSDSMMKKRREKILLDFLQRLRRIFDYHDQLYAKTNKITEMIKIPKKILICSSHLLSPLLSSVTAAKRRRRRRRQQHQQQHQQQQTMFNGNNYSPSMPLHNNKQNEFRPEFDELDMNDFFDPTESTTISDEEDGYPKILANSHKMLPSSSSISSASKSLNHSLFSSSILNHQQQRNSITTTTTTNFNNKSLIIKSSIRSIYHYFDLVHFELKLQPNRIDNIRDQMNYVFLNRPLDFPPIMWSIGGSTKHKRLVNRMNGTNYSLASLFVLAMMPGTISIFYGDEIGLSNVYDFRSHNVFIGSQLCPMAWSSESPNGNFSLPNVSTSSWLPIHPDYTHINVEKRSEMVKIVAELINFRLDFLYIDDLETKSLNQNQQFSTSSNNQNNKKNLLTKESKSSILNHRINYLFHYIDQTTIVLEQYFDRINPSKSSTMITTVDNHHRLMAGDDIDVLSKYKRYRYVVFANLGNETIVRDFSDKFHFSIIQMATNINRTSEFLIMKSLQLDPGEAMIVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBI7</accession>
    <name>A0A922IBI7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBI7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="207" mass="22893" checksum="3BACCBF35E643631" modified="2023-02-22" version="1">MIVNNGDDRVFSPNIYTISWTVQLPIAVCRDINKQCINRVFKKKPSRIPFNIRASLMIIFDNSAITYYHQAIFTIKQFSCSWCAVRLLLTKSHIQIELVKHLQMISIPIEYILKLAILISECLQQSLLLRTKIHVAVRADVDDDNACIDGQNVAEAADVDDDNASIVTENIDEDSSSLSSSSSAKSVATQTPSLPSASPSPQSSPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBV1</accession>
    <name>A0A922IBV1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_002568</name>
        <name evidence="2" type="ORF">HUG17_10528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBV1"/>
    <dbReference type="OrthoDB" id="6505902at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324717" evidence="1">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7636558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="241" mass="27251" checksum="FEB8EB8521A411C5" modified="2023-02-22" version="1">MKFFIVTILAITGTIVLANENPSPSSTSGKLNMQQVEALLQQIEKDEARLKPNVPNDPTVTVALQQLFTQFRQLTGAYVDVLNAVNKQIGLPKYPKLPGLTRYRRGIRETAPFKQIIENVEQLGTSISEVGQLVTRTVSSISDDSRKTVMKQFQQFTDLWSSQLNEISRMFDPSVMAMYSANELQGRDDNANFVDEVQRQVQQLVKDIQRYVDNFVNSIRNRVTGLSNQVFPGERRPVLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICP2</accession>
    <name>A0A922ICP2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sodium-dependent noradrenaline transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SLC6A2_1</name>
        <name evidence="16" type="ORF">DERF_003003</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICP2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="15">
        <location>
            <begin position="92"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9529096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="396" mass="46076" checksum="4A06B519A46B9B3E" modified="2023-02-22" version="1">MGRFSILVDFWQEPAPINNFTAHIMITSQNRDKVNKYLQNRHIRSEILHSNVETLIENERKALIKADHLFQLINANNKVGNTSEAIAGFWTKYHRYEDINRFMDELSKKSNNLVEKFVLGESYEKRTIYYIRISDSKESEKPVIYIQGGIHAREWISTAVVTYFAQQLVNGVINSDLNTLQLIKKFDFYITPVLNVDGYEYSHIQRRLWRKTRSINGRSISDCRGVDPNRNYDFHWGKKGSSSYLCSETYSGKKAFSEPEIRAEADFIKKKLGKRVKVYIAVHSYNQLWLYPWGHEIKNSPHVEKLSEKAKIATEALYKRYKTRFQYGSSIKFQDVTSGESIDWAHGKASIPYAYQVELRDTGEYGFLLPPDQIRPSGEEITDAFKAMFLSISKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ID47</accession>
    <name>A0A922ID47_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MED12</name>
        <name evidence="11" type="ORF">DERF_003170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021990">
        <property type="entry name" value="Mediator_Med12_LCEWAV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12145">
        <property type="entry name" value="Med12-LCEWAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="10">
        <location>
            <begin position="103"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="760"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="836"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1933"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2090"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2163"/>
            <end position="2230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2242"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2323"/>
            <end position="2448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2477"/>
            <end position="2542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="584"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="847"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1949"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1984"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2003"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2099"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2181"/>
            <end position="2194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2221"/>
            <end position="2230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2242"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2256"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2323"/>
            <end position="2357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2358"/>
            <end position="2379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2418"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2437"/>
            <end position="2448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2477"/>
            <end position="2493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="2500"/>
            <end position="2515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="2522"/>
            <end position="2542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9529279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2542" mass="287962" checksum="4628F5A4CEC34ABC" modified="2023-02-22" version="1">MSTVLISTHLYEKRPLKKPRLGPPDVYPQDPKQKEDELTQQFVKQGYSNRTLQDEHEYGTERNANINTSRFGEYFSAILAKKHELNTFSDTSKKKHVVNKDSALYVTAKTKPYVEGWFKDLASNTKSLAHLSKKVPFFNKKEEIFVWLYEYSVPMIKAQWFLKVSNAHQMAISESNNKSKKRNQMPDPSQEWTASLCKTLKENYMKIMESTNPNMNNAGSTFSSMNNSLNSPPIKIKELLNQWEYYTRLARSLYEEGLLDRHDFLFWLLELFEKIKSIDDPLLTLIAPMLVQYVNEFIHSEFLSRHLAFHCAKKISQLVAHVSSESSVDTDKENVNDHKDPDKISSSNFNTNSKSSLNESTDSVMLISCFKDIIACSKFQELLLALSCVIQVITIECPTALVWHNFDSSSFLDNSNSVSKTALLHGSPLDYLPCEPSNLPIQSTENVKHLRERIRSSENLIRHRSANSEKRWFFRTFEAVSSPDSVGNVVNRLLDVLDSIDKHSFDKVTSSNPLDSLYNIIFNTTIHFDGDNSYGSHNERNRVNSTANKSIQEIIAEDVAVVKLLCEWAVTTKRLGEYRSRIVAKLLERRQNEILQEKDNFNNEVENAEINKNHVDSDNKELTNGWNNNENKSTSIINNDNIPLYQNVLFEFLDQYAPVAEDKTLGIYFSTNAFPNNNCSSDNKQAFHNLVLLFAELIRHDVFSHDVYMRTLISRGHFVNPPNISLIPSSNSNHPIKNTNEDSLTGLLPPNMETVSNGGLMNPLHKSTSSSSLPMFDPLSNNSNLNSNEQLVSNMFSINEDEDKLDEDLDKILQNIKAGQQSKDDQNDILLPDAMESDKEDETNGPNSVNTNSTSLSDLTNNNKNQLSEQINATSRHLLYTLHFPLPQEESFMHECNQRHILLYGVSKTKDEARHIVKKVTKEIQKLFNRKSSLDINDNGKVKKHVIKEGFNFENAIAKFQNLSIFDQHVVTNTCASTVLEMLNGVVVGSANHLPLIESIAFLFDLMEIALNVNGLVEFIVQMLRELVEVESVLKQKCPLLARPYCTSIGLYIVGVLNRYHNYVVASTEDIYQIFDGLWKLVRNVSTPNDCSSAERCIFFYIDDLYSSCAYVLKKYQDIISPISQKIKTMIAIRDDNTKGSLNHPCVMMQYLKNPREKVDSIHIRQLNENASDRYSLVFNAIRCITEANDMDYLNELSVLCAELTASCWLLSNEWFDAIQALCNPKCMNDYISLLTQINIGDRSIYDNLAVFVSILVARRCFSLVDLIYRVFIGSLLIPTVESGEETERKARLCCHLILYLFKYYNSPLAASNSAMNSSFASSSRYSLTSPGPLGLSTVAPTLGSGQKSPFNIKYACDRYLLGGALNSLQLELILTLLKAIMRLGTQEKKGCEKNFKSDKSDFDSFYKPMNNEDEFSDRTYLSQIAKSKIDSTEKPSLSDFAKYVLRQVCLQDWVHDRCLRGFMIQPNSVKKLFDKKISYEDSQCLLNMICYHKQIMPPPVNINEKIDSKQIIHIFQNLDEWSLRISWLQLHLIYENLAINSLSPQSNYEWLDTLAPAIMDYFQQSCQMEPVLNSKNLTIFTSNSSNMKNNMLTFGNNNNNNSNERIWLLKPLISKLPLQSKILRFAANMFDSSNWILYSQNQSGSMSSKSKFGFQGFKNSNNLAGITLNNQNPTTTLLSYQPFVSLLLKCLNSKEDHKELILKSMHSQLLQCINEKLSDDVRSKSFIQEGLQLRLSLVGAIFETIKSSTSLTNDWVVLLAQLISYTIVDPHINYVNFSTVLDMLTSLMHYSHASNVLPEQREETKKLNQNLIKKLKKELNVERIGLGVRMAKQLLPLVKHQAEVIACEAMGSLVDTKGNKIAGFDSIDKKQGFQAAEKQKLSPWDLIEGVKNYVPLSWTWFGAIKMERKPLRMEENFCLLARHDHDIYPASSFYIESPPVPPEDEPPQLQTQPQVSSQPIMSQNPLPPPQLGYNQAHPVIAPNGSNISSVGQPTGPAPPSALMNNIPPQSHSFNPSHQSTMHHQLHQGPPHSNQGPPSNMGPGGFQYHMNPIAMSSNNILHGAIQGPAGPNGTTLPPNVMHSSPIVQQVPTQQPPHMMNSSSNEPTSHMNPQNHPMMMASLNNSSMMPMQMDMMDTPPSGQPNLGRSMPGPGTIPGLRPSMTPSNMPMPPMPTVNTRAQAPKKPKATRKRRNAKNQQAVNIAPMPNQPTPPVRMSNSFDNYNSNQVNSNQNAATNWNYQNQNSQQSNMNSNNQSFYHQSGSGPGPNQTGSSMMIPQQAPNQRFQGQVIQPKERLRAMLHHRHPNPNQFNMNQNEPSVTNVVNSGPMMNNQQPTGQMFSSRHQMPSMMQKTQIRSQGPQPQNNQSMTNQNNMFQQQQQQQPPPPPTQQQLNQINPAPMHHHMQQSSNFRPPPSVQNVQFNNNMQSMDSSMSISANQNYQQPTSNSQQQNMMMRPQMAMNSQQQNQGQFMQQRSQFTNFGGHQVPPQAQQQTQQPQPPPQQQQMMNNWQGNQMGQNHPRAPMTQLQRQLSTPNPGQLQGSYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ID83</accession>
    <name>A0A922ID83_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ID83"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10472" checksum="8E12467D6F9E16DE" modified="2023-02-22" version="1">MNWSGPSHRYNNIVLYDDDESDHYERIVFTDPNGYVVAFLSLIAIHFYFNPIWFKNLNFIFHSHHYSDDDDDKMPTMKSNLHLMIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDC2</accession>
    <name>A0A922IDC2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002554</name>
        <name evidence="1" type="ORF">HUG17_10515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
            <tissue evidence="1">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="1" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDC2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH7636545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="120" mass="14282" checksum="264158124E016210" modified="2023-02-22" version="1">MVWFNVNVLQPSMVQNTRMKMYLFRDHFELLCTEQSPTFIGQCGWQEINGIHVETNRSIITIDRSKRSSSKSKNHDRYRIQFAIANEMRQFLDFVCIICPRMICHYHSNRSDTLQYIVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF56</accession>
    <name>A0A922IF56_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferritin</fullName>
            <ecNumber evidence="6">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FTHL17</name>
        <name evidence="9" type="ORF">DERF_003676</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ferritin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="6"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF56"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01056">
        <property type="entry name" value="Euk_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431:SF75">
        <property type="entry name" value="FERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037195827" description="Ferritin" evidence="7">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="8">
        <location>
            <begin position="43"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601519-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9529813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="218" mass="24861" checksum="DDE734079B885CF8" modified="2023-02-22" version="1">MRSILLSSIFLLIFSGSCLAILDAFTDGLDLGGYSLPRSVNNYELHDSCLIELRKQMNLEKHASLVYKQMAFHFGSIKMARPGFSKIFEHHSTEEHEHSNKFIKYIDLRGATIGSFNITMPHKTSWSKALEAVEDAIELEHFVTNEIIRIHRIAEKTCKDVHLMNFLENDFIEEQISSINKLMKLATLLRSVGGNDGGYGEYLIDRDFFNGKLSLDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG49</accession>
    <name>A0A922IG49_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Atg14-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Dysbindin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DTNBP1_1</name>
        <name evidence="5" type="ORF">DERF_003594</name>
        <name evidence="4" type="ORF">HUG17_5501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dysbindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG49"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007531">
        <property type="entry name" value="Dysbindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16294:SF6">
        <property type="entry name" value="DYNAMIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16294">
        <property type="entry name" value="DYSTROBREVIN BINDING PROTEIN 1 DYSBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7642456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9529725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="451" mass="51653" checksum="23431297C50D2554" modified="2023-02-22" version="1">MASAPIIIPILCLIVIAVFLLLCTYRVIRSLFGCPHQKSSYLFEPVNQKRRSVLPSNPYTIDPSSPASNGSTASPNSVYYKGGMLFYPALASASAPSRSPSPPRDPDDDDHKSDIQDEIIDLDTVDTRIDGESSMADTPSPNSSNTTREDTNNLLTVHSTDSSSPEHLNNFKHIPDDEHDNNRWNNNHFESDILFEMFEHIRDRIQHVQQDLTTSFRELTIGTIVDSPATYPTSLSRDKSNLYDLDVNLYAGADVIEYFQHRWIEIQNETKHNANKAQSVSKHIGQMRSHLKNFNKTTDDLESELDKLAPEIHDSLLEIEHELERSLLLLNKLNEAVICLNKEVIDCDHQQRKDESKQKLDEMLIRRAEDLVIYEAQLRSKYERQEVAILKERQLVFQQAFEEELRLYKEKGLVTESNKLKEPSDGTRLEDISLDIDQDEANELEKFLEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGF8</accession>
    <name>A0A922IGF8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphopantothenoylcysteine decarboxylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_003151</name>
        <name evidence="4" type="ORF">HUG17_5160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGF8"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="3"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7642115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9529259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="190" mass="21200" checksum="BB07062F9BF4EB47" modified="2023-02-22" version="1">MTNILIIVTGSVAAIKLPILVKKLQEKCLANGHLFQIRIVLTEPSLHFFKLVEVENLLPAGSIYRDADEWTTWTKMGDPVLHIELRNWADIGVIAPLDANTMGKLSNGICDNLASCVVRAWDINKKLLYAPAMNAHMWTHRITEKCIRVLNDLGYIQIGPICKKLACGDFGMGAMAEVDQIVAKIMEFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGV4</accession>
    <name>A0A922IGV4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein fam43a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM43A_1</name>
        <name evidence="3" type="ORF">DERF_002992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGV4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF2">
        <property type="entry name" value="FI05246P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="39"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9529083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="354" mass="41634" checksum="B1A42E5F23E01FF2" modified="2023-02-22" version="1">MATMDMEDFILSKSNFPFNITLNSLKFWKKHSSSITINEGEYCQKVTYLGNMLTAWAKGDPSVNRALDTLWNNHDNRKNHQNHTDIQMRLTICNSGLKAETKQYGLTEYWANRITYCCWKQKYPKIFCWVYRHIGRRGKPELRCHAVLCQKEDVAKRMARLLEERLAMALREFLREKLIRQRARMSLMEMPIRKQLLVKGMANFRPPIERSRSAPRLVSILEDAQQEEDEERELLKLFSKEEEEEEDYEDFAEMSSISIDDDDDNGSSGNSGNIRLRKCTKHHIDDDCDCNCDDDENDSAIDSESFKSDEIICINDFQLFLEFHQTKITPNKTKIKNCRRLIIIIENKFPIHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KU57</accession>
    <name>A0A922KU57_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KU57"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="115" mass="14177" checksum="55E206BC4CC1B967" modified="2023-02-22" version="1">MNECEMSLKKKFLFTIPQRSIFTTHIFNNNDNNFFHFFYALNHNQQKKTMFIKRQFVEYIVNEKKKNGYIIVAQFTPISFVYIGQNYYYDDDVIWNHWPYINKKQKRTRTKAILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVQ6</accession>
    <name>A0A922KVQ6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_015814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVQ6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9491078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="168" mass="18467" checksum="2B1DC7530D571F4B" modified="2023-02-22" version="1">MLVLLEPLEFDDVGDVIVFAVNVEIVFDDDDDEDTEEGVDDAEIDGRCEDCLDDDDDDDDESALFALDEEFDDISGDVDCPTGNNISLLFANVCFEDVAEEMVGDDEAENIRLLPATTCCCCCCCDLLESDDDCCDFRIPPVAINDCDPPILLEPIVIVIGDDLFEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVV3</accession>
    <name>A0A922KVV3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine deaminase, tRNA-specific 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ADAT3</name>
        <name evidence="4" type="ORF">DERF_015900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVV3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="155"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9491168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="323" mass="37600" checksum="1C3276A5E4F5A65F" modified="2023-02-22" version="1">MFQSEVILSDIYKDDAISTVKVLVLQLSDKAKMTNIMKFLTTKLPMTQISMNHLKRINSKHDNFQILISPIKDSSCYKNVDIIQKTINEMNEDLREFLLGFDSDNLCLREVAASSPLTRNQFERLSPLWPVNFFENKYIAKCLDGSIFSPDHWKRIHELMIETLNMLNNDSPSCMSSIIVKDNGKRIVTKTISRTNQHPLHHAVIVAISNVAEIHKQAKEQLLKDPDSFQGDNHYYKDDYLCTNYDCFLSQEPCIMCAMALVHSRIRRVFFFESTTISTITNECYDQPYTVQKLHINSNLNHRYEVWKLSKQENYANKKQRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KWF4</accession>
    <name>A0A922KWF4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KWF4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="83" mass="9775" checksum="F2B62C4AD35AADB2" modified="2023-02-22" version="1">MDGDDRIFERIKLISFATCFNVYDDPLNVNVYIIVIDNNYNLSFETKKKQRSDSFPCFKDIELDTKRIERSSLSDQSIDDQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KYR3</accession>
    <name>A0A922KYR3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KYR3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7526" checksum="324438A18B2B4FDE" modified="2023-02-22" version="1">MFIIRKQQQQQLWEEYDYQNVDDVDDDIIVEQCQCLNRISIKTTTTKMPITLSSIWNPFSVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L096</accession>
    <name>A0A922L096_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L096"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="113" mass="13113" checksum="9C3527EAAEE04E18" modified="2023-02-22" version="1">MAHLGMNKDDSRYLEFTMNVTVDFKFQNFNLPLLNIHNQCGYDNQLNLPLSSSRIFVRTIFDHQKFQPMAPYPTALERQPDMSEIPPKQSWKEAASLIILAPDNKQKMNNICP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0Y1</accession>
    <name>A0A922L0Y1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein chibby 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CBY1</name>
        <name evidence="3" type="ORF">DERF_014061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0Y1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028118">
        <property type="entry name" value="Chibby_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14645">
        <property type="entry name" value="Chibby"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="218" mass="25268" checksum="C59D3B7C54E62DE1" modified="2023-02-22" version="1">MPLFSSKFSFKKSQSRRRQSSRPMIVENNEDDSDKSITSNEDDEDDDKRQNVLDKKQSKIIDHEKNTEIIELPKNITNKRRKKQSNNNQLMSPKTKQQAQQGDDSDQMILIINTDHRYRFDPRHGIWNDLKATMMITKTIEDDQLKNSTNSIDNDSEKQIKNLLKSIETLQEENRLLKLKIEILIEMVTETTAELNLSGNNNKSTITATTTATAKTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0Y8</accession>
    <name>A0A922L0Y8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GINS1</name>
        <name evidence="9" type="ORF">DERF_009515</name>
        <name evidence="8" type="ORF">HUG17_7410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0Y8"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="6">
        <location>
            <begin position="65"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="7">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7637204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9511029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="206" mass="24163" checksum="094CD8D45D3AC466" modified="2023-02-22" version="1">MFGEKCVDLIKESTRDSSELIAPYNQMMVNEVFDEMRLISQTLFESLNSDNEQAPTSDEQQSNYDSQNRLLVNKVYLRAFLWNKRCLLAYHHHRLERLKKIRWQLGAILPDEVKCNLSEDEIKWFAAYSRNLSDYMNRLNDNKGIDLTLMRNPPKKLYVQVRCISDYGPLELDDGNTVVLSKDSMHYLPLSKCEKLIHQGVLEQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1T8</accession>
    <name>A0A922L1T8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1T8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="7494" checksum="89D0607E85A54907" modified="2023-02-22" version="1">MHKIIHIMWMTNITNRFRCNITECISSKAIVWCIEICTKWWWKYSIITMKTMTHMMNNIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L271</accession>
    <name>A0A922L271_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MutS protein msh4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MSH4</name>
        <name evidence="9" type="ORF">DERF_012894</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9502100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L271"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein MutS core" evidence="7">
        <location>
            <begin position="378"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="795"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9502100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1087" mass="122843" checksum="1639D9CB1B5A60BA" modified="2023-02-22" version="1">MNSEDNPSFSLNNSSPSSSVGMAREFRSYAQDAAQFKFAHSMPFNNNNSMKLTTTITAVTSSSSSMAVANVLENHNCHLDNDDGPSCGHHSNDNDIDRFSLPSPLVESISSIYSEESRQTLKSPPSFASNDWMRNNLPLSSQSSSRGTLFDISNRINITNPNQSFVPKHNRSYGQNNASYNRSKTLNTSTVSNVGMNASIHFQSEIVMSIVEGRGKAKGEIGIAFIDLKSIPILHVSQFVDNYSSESLRSKCQVHMPVEVIFPHTMSSNNRMMSTLIESFPDIVYRPFNRKFFNEKRGFDIIQTLSYDDCQWIDLQLENKYYCLAACSALFHYLIVVRQIQYAPKSIKIIYQSSLNTMIIDPLTAKILELIINLADPKSWHTLFGTINRTRTKSGYILLRSNILQPTTNLELISKRLDMIEAISSSMEIFNSFENLLDSFGMVDLDQLLVNMVLVPVNSHHQSYDNNRSNDSDLSQSAEVSTSTMSSNTTAGVKSVSAVVIRLIEKKIDYVINMKHVVALVDHLRNLLTKCNPELFAEYIQLLGDPGYEQIKSMIDQVINSEAKCVKSAFGLSVASGKSNTFNSSGSAAMKLERCYAIKDRFNPMLDIARSMYSETIDDIVALTQAYGNLPGIRLNFNTSKGFHMQIKPMKSNDKNKDKHNINRGPILCQQKRLPSIFKDVHVTKNCISFTSDDLTRLNNRIRQSIEEIYLQSDNIITGLIEQIRTKISCLYNLTDIVANIDLVYSFAYQSLCANWVRPQFSSHYTEIIQGTHPVLDNISGGISVPNSIFLSNDLNFHIITGPNMSGKTTFLKQIGLIQILAQIGSFVPAQIDTTFRLCDKIFTRMAMNDNLQMNSSSFMVEIKELHYILNHISPNCLILIDELGRDSSSTPDAYDENAAVVNNKIMESTFPTYWSFCESLLMSQSSFTIFATHFPQLTSLSKYYFNVSNHHFSSEERLENNLICKYPHILRSGRTREQFYGILLAEQSGLDEKIVSYAKMIAQRFRPSSSMFHSPSLRSLFDITDATVDNEIVDILDEELQAKYRIAARLLHFMMTNPQAEINAIMVRDLQIMYEELRQEFLDQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2J6</accession>
    <name>A0A922L2J6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_013678</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2J6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23599">
        <property type="entry name" value="TFP_LU_ECD_Cold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036">
        <property type="entry name" value="CD59 GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036:SF3">
        <property type="entry name" value="PROTEIN SLEEPLESS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036932780" evidence="5">
        <location>
            <begin position="20"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9497715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="291" mass="30837" checksum="4B0DE840436CFA02" modified="2023-02-22" version="1">MKFALIIVLFIVVWDPICGSRFGRPDNYYDIMILINGRALPAQSAINLPNILVTDKQTGREIPLRIGVRKIVTEEENNQGNNGGGNHGDGGGEQNGGDHGGGGGGEQNGGNHGGGGGQAGGNHGGGGGEQNGGNHGGGGGQAGGNHGGGSGQAGGGHTGSNAMVTSYECYVCNNQEDNNGKCIRTVRTCNLDDNSCMTVVRWGSTPYWDPTGQKQYYISKRCTTLAQCQEARENSSRRCDRIWYNDWECVECCTGDRCNYYITLGTSTIHGNMVMIIVSIAAFITIVTYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2S6</accession>
    <name>A0A922L2S6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2S6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9515846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7212" checksum="D600564B10574344" modified="2023-02-22" version="1">MPFSIYLSSSSSSSSVVMTDVRNKTEISVDCFVYDDGGILNLIHIHHFFCFDHGHLILYLRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2Y7</accession>
    <name>A0A922L2Y7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2Y7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="435" mass="51645" checksum="DFE9FBDF618D6ACC" modified="2023-02-22" version="1">MDCFRLIIKNSVAVILLKIANLIWSKTESSISEIIDSGYPYLQYLFLRFKYSWEEYEQQRIPKTFRRFYAAILISLNAWFNIIFLTIYSNTESSIWINLKDIEKIIDCERFDLLVIAFVILFGIGEYTWFCYFRQAITYKMFTHKIIYKNLHFDDTRLATNYRRYIFIHHLFIKISAHLCGAFIITGIIVAYVIDTYIVIQAYINNQITIEKLTLCFFTFPSLAIQFISISTMLLAGTFASSFFVEFLKIRMKQFYIFLKHNESSKNIPKLKFNWNCIHREYVELYDETALFDKSISFALLNMETASKILSITACVFYSRQTKMSPTNTMIMLGISLAFVYTAILYSRLVFPPKYNHHYCRLLLNRMARKSIVKYHNRHKNLIIKSNLFIQTMSDNHFGFHCGQIFFITKFQVVELFMMNLPLIILFYKKICMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L311</accession>
    <name>A0A922L311_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L311"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1218" mass="133666" checksum="009805A5D070B934" modified="2023-02-22" version="1">MKIGDCHLFFYLIHHHYLSDYSAPIAIVDSGNHKKSSSSPSSSSSSSSTSTTTIKTTTTATTKSSSPSPPPTPPLSSGTPPPPFSSVVPSSNVIILNSGGGNFGGNIIAATNNLETTTKSSSTNKKIYTIDPIALKKAEAEKVAAENLAFVAGGGGGGGEDSALKADLKQILQKLIQASETISMRTMKFLSLITVLIVLVTLFTLVISQLNKDETKHEYGIAFPLEENESTQRLQQQLASLPDLINGNVVVGLPSSSSSSSSVLAKNDQSATTTTETVATSTSSFNKNQNQNQLKRQQNDDGQSSLPSSTTTTTTSTMVTKNLDNQTMKTTKDKRNESNSGKDKDDNDDDDDDNDQPSIIVLNNNKDDQTDQSSDQLSDDRSTGSINPKLIFIERLMDLNFQQQPSLAPPPRSPQTGLSSFFDMRNSPLDSDSNKTTTVDNSDDSDNTFDNIRSKWENRIRKFTYPLQNTYSVVLRSSNINNDNNGPTTTTTDNSSDNEKSNKIDPNQPSMSNNNDDNDDDDDDRPSVKFFFHQSIGGGSPFNGFTTSSMPSSPMNNNNNVNVNNSPNSSQTNQLFRMAALTMMSKLFSALRSQAMTPPSPKIMMMMENIPKMATGSADIDHSNDNHEIDLDDDDDDDMDGDNDRTTTETISVPILLGQKSRQSSLSSNSIQDDSSDSDQTIRTTIMYGRPSPPSSLSLPISPPLMMMGPRYYPTSSQHQQSPTITNPLAAIIQAIASQTRNQPNYNRQLESQPITTAAAEQPQRLILLITHRSMPNVIEPSSREESSPTIMFQQSPTNQAQQQPNLAYYSPLSPPLSPILYQYSQAQSQQQPSPLTMAIPQQQVRPHVVEVPVPIYVPVRVRAPIRSSPPQQPAQMISSIKPSIIHRSSSPVSNPSPMAVVYYHGNNNNINEPTKMVVNSEQSNGGRGMAMMMTNANNENAYSQQPLFHTSSSEPSIDFVDQQQQQSSPATVAVNHAVVRILLRPKGPTSLLSSLPPPSHQPQQQQQLLRRFEQPAEFQPEEDQSHPIISHISMPMMQYADSRLQQWRDYQQQQQQQQQQQQQQQQQQYQQIQPHPQSSMTHIILAATTPATRPLLSNNDDNDIGIMEQPEPIHPHHHQQHFITSGSSPSSTPYFYSEQIEQQQSPQQPTTHMESIQQPPPAPHHHLLQTTNVVPQIMTTTNAAATTGGNNGDGGHAAFLILADPNVETMLSHSQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L370</accession>
    <name>A0A922L370_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAH9506846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L370"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF16">
        <property type="entry name" value="UBZ4-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="1 2">
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
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                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
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                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
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                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
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        <source>
            <dbReference type="EMBL" id="KAH9516311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="44" mass="4998" checksum="D97204E2B093A5D0" modified="2023-02-22" version="1">MAKSLKETLGYNTKTITSLFDNNAAIRRQQQKFQPSKLMGYMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3L7</accession>
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    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
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    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="144" mass="17064" checksum="D65AD7BFAE8B76EE" modified="2023-02-22" version="1">MNWLTNIIRWIMSEDGKVTKKILPSVYDRKIILIDLHFVFTQFLSGHGKFNVYLHKIGYRYKSSTLNEITVHQSINPDKLTPIYQTVVKILWLKSLIINIYCGLRSKIGSEIDEDRLVRSSCNHDTSWRKNPIFDDFQIVHYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4D2</accession>
    <name>A0A922L4D2_DERFA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 3">
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
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                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4D2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9506264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="130" mass="14217" checksum="F77588BECE9C9FF5" modified="2023-02-22" version="1">MSTNFSQIISATLPLVDDDNRFLPPSDESLLVVVVAMPALDGLNTLAMYDQPTIFCTLNACIESTTSVQLLHNSGCLWMPSWDCWSTWPPVTLLCSVVAVVVADVRLITPEPPAAVYGCHPDAGRKWYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4I0</accession>
    <name>A0A922L4I0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4I0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="59" mass="6579" checksum="1390685268F3F066" modified="2023-02-22" version="1">MNKSTWNVDSIHSEWNTICNIKYRTDLIRAIIKSLSAPQTVINGNVPGDSSVVKNSAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4T1</accession>
    <name>A0A922L4T1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear pore complex protein Nup153</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">153 kDa nucleoporin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Nucleoporin Nup153</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DERF_008883</name>
        <name evidence="23" type="ORF">HUG17_4765</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">JKM2019</strain>
            <tissue evidence="23">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="24" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NUP153 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6437724at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF23">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="22">
        <location>
            <begin position="626"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="22">
        <location>
            <begin position="712"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="996"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1047"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1288"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1052"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1293"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="1329"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KAH7641720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAH9518293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1338" mass="145264" checksum="F72CAF2C9B1EECB8" modified="2023-02-22" version="1">MSKNDNESRGTIYDKIHNERPTLSSLSEQQKQSEESNNSETATSKSYWTKPPPPTLSSSSGVERSINTGPGYSRSSLYSSVKRLNLFPKRLAGNDSDVIYNSNSFKRFRANNNNIENLTDSIHEPSIRSRVSHVSTPSSTSSVALGYLTSEFGRKQYPKAPLSITGRDSPSLIMNNLNLSSSISNSGRNAMTMNQNRKSTDSYFYTGKTTFGGSNLRKNIHRLSMTPYSPYARVNVKCIEPMVIQRPPSTSGKNISQSTVDEDIPLSSVTQRILDRLDKAAAPISDAKSRISLSTLINNSAKKFNTNRTPKLFDTPTPIFENHDRSHIDSSFKPMKYVLKPSLSSTYEQTTTSAAVDKSIDDDIQKLNQIKQAEKELQKQQEKLQTKTFIEPALRNFASSSSGKITARDVKKGRKIDDVLEMDNSHLKSLANVQPLATMTTGITLKPFSLKSSTSINNNSDKSNTFDIRSTCDTINVPNCSTINNEFSFKFSSPKLVASLSPVAVRPTFQEIGFSSPIQISKSKPVVQSESTTSTTTKSLFDQFKHCIQSTNTWTCPICCIQNDNIDGDKCIACEEPNPNKKSSKDNQLTEETQRPESLNFGDCKKLTQNSSLSSSLPSLNQLFKKDASKNWTCPTCSVSNNIEENRCISCEEPNPHKNKKTSNNQLNNLAKFSFGSVSSDIDTKIVSVDENSSTKTKPSLFDVFKKKQSQDKQQWTCPTCMVPNESNVNRCVSCEEPNPNQPVVSQTKSSTKTSFGFKFGSSNTSFQKDHPSREEGWQCFYCKAMNKSDISGKNVCNECGKIKVMAATKDQVQKFYQTQTFKFGLSTNNTNKDVKAETKFEKQDKTSTDIPTSSSSGGFKFGIPPSSTVSDSLTMTSPFSSSKTTVPFSSSSSSIVKPIVSMRDTSSSLFSFGTTTTNSATDVSFEKTTKPLIDAVPAVPLSSSLSLFNFGTTTTNSATDVSFEKTTKPNTDTATAVPVSSSSNLFVFGVNSSKSATRSENKNGDESSNDNADKNITPFGFNAISSTSSTDMKSSMATGLFNFGGAKQDSSKTSLPSSFSKDTSTSSMPSSSFTFGGACTSVTSTTTTTPTSTLFGKDLKFGSPITVPKIDPGPPIPKITISFAHPGTATTSSTAAGSVGQSTSNTLFSFGSSNITINANPTPPSSIFGSSSMPTSFNFMGTNTSSNNNGSMGTSSLFTFGAKPNNEPQPPLDKPAMVGFNFGASSNPLSFSGASAAATNNNPVMPSFNTATPSSTLFKFGSQDPSNLSFQSFPTSKVESNNLSFTSSVLEPQQQQPDVQQQQPNSLFQFQSSNSVSNMQQRPNQPRTIKKAKRRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L623</accession>
    <name>A0A922L623_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PTPN11</name>
        <name evidence="14" type="ORF">DERF_005315</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L623"/>
    <dbReference type="OrthoDB" id="8815311at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09931">
        <property type="entry name" value="SH2_C-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10340">
        <property type="entry name" value="SH2_N-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000012">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000045">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559:SF3">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="14"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="123"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="250"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="440"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="593"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9521681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="648" mass="74190" checksum="74DC393C3613D899" modified="2023-02-22" version="1">MPMTMPLINSRGRWFHPNIDRVSAEKMLVDRGVDGSFLVRPSSSHPGDFTLSVLSDSAVTHIKIQNTEDDLYDLYGGEKFASLVELVHHYMQNPDQIRERNNRNRIFKLKYPLISEDPTFERWFHGNISPQEAERQILEKGKNGSFLVRTSRKPGDYVLAVRIDDKVSHVKIYCQQSKYDFGGGEKFDSLTDLIEYCKRNPIVETSGTVVNLRSPLNATKITASTIENRVKILSKEDGCDRKDRERKTGFWEEFEYLQQQACKHLYSRKAGEQSENRNKNRYKNILPFDRTRVTLKDVSNDDGNDPASDYINANYIQVEDELTNQPSKKVYIATQGPLANTKNDFWSMVWHEKCYIIVMTTKEIERSKPKCVRYWPDKDQSMRYGKISVKTISEKTMLHHTLREFRIHYDDNEKDSRIVYHYHFMAWPDHGVPSDPGCVLNFLHEVNCKQESIPDSGPIIVHCSAGIGRTGTFIVIDILIDQINHHGLDCEIDIQRTIQIVRTKRSGMVQTIAQYKFVYLAVQHYVNTLQQRIQAEHKSLQAGREYTNIKYTNEVGDKFTSYGIPATAATAASTVMNNNNNNNANAMIIPLSSSTSTTSSSSNLSTTIQQQQNKSCSSQIELQRPPIPPRLNRLTNDCPYGSSSTNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L679</accession>
    <name>A0A922L679_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium voltage-gated channel sub KQT member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KCNQ4_6</name>
        <name evidence="2" type="ORF">DERF_005085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L679"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="431" mass="48884" checksum="CC5FEA5A3BD51A84" modified="2023-02-22" version="1">MINSDSLQTDRSNNNESTLSQPSCESSSFDTSTTLSSNETCCCSCNNNYDDDDNTLSTTITSTTTANQCYCCVTESSESSASTLTLTSPESPSCQLTGGGGGGYCSSNNDDDDENRIDIKVKSFPIDNDDDEKGKQDETTLIFIVDPKSNCHSQSQHKCLRRTTKTTTTTTTTIELDEIIAKETNSGKLMTNDDDKYDSYLELHRWKKISSLMEMDKLTKHYDAGGDGNKDGQQQLRRPFKRRVEFIMDHHHSHYRHHHHHHQQQQHNQHSIDNDSREQLDSDSVVVAVGNDNDSVDDNDNDNQSDSEDSKKMPETEMENCIDLNADDDGDSMESNETTDTKAQIRRESDLLSFLRSSTNSGHQIHRSSAYNAFRASKRSQMHRVSLLGRPIHCRQHRHITNPRYKQLQNDLHNFLERPRGCSPMFYHITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6C7</accession>
    <name>A0A922L6C7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6C7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="6952" checksum="8C08F3C8F407A53D" modified="2023-02-22" version="1">MEVATATTTTTTAFHSFQNVDVSGLNAIGNNNDIMLLKMTTTTTTSKVLQETVVVNESTNIVCPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6U3</accession>
    <name>A0A922L6U3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6U3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="87" mass="9971" checksum="4D17F9A394B30807" modified="2023-02-22" version="1">MKRIIELYCSIVRFFELRIEVHVQDLVLFSLNKTLRQSFAVVIGTTIPIAVIAGIVIDGNNNTGVDGVDDYQHQHYVDDDEDFFLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7H7</accession>
    <name>A0A922L7H7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7H7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="88" mass="10289" checksum="66635380059BAE62" modified="2023-02-22" version="1">MYLKKITPVSNCSTIDFSPSKKKNFFQRNSIWSKKKNICLIHVIYESINYIIISTITTKHVYISLHLLSSGLLSLNSNLLFKLRKQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L845</accession>
    <name>A0A922L845_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">COA3</name>
        <name evidence="10" type="ORF">DERF_004844</name>
        <name evidence="9" type="ORF">HUG17_7783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L845"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="8">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7640316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9521172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="85" mass="9838" checksum="40B5765E2418E1FA" modified="2023-02-22" version="1">MSNNQQSSKMKNEPPIDELQQTFIRKAQMMQQQKLGKVNAIRMRNRLSGAFMAAVVGSIYLYTIMTVKQEKFLDELEEPTDNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9N8</accession>
    <name>A0A922L9N8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9N8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="8046" checksum="CE9DB34D8910BA3D" modified="2023-02-22" version="1">MNFDQFYLLNLYSELMVIGHTYIPAASIIKDTRVIGRQDNDRFIIIIIPEDILYNTQQILHLNHWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9Z6</accession>
    <name>A0A922L9Z6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9Z6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="7182" checksum="0CE9A5316098CF54" modified="2023-02-22" version="1">MEIKRVYIFIQARKSSLVVYVDDILSKHIEIKSLGNVKNFCGLEMRKEKNIFQTSQRGDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA20</accession>
    <name>A0A922LA20_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_000284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052774">
        <property type="entry name" value="Celegans_DevNeuronal_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056953">
        <property type="entry name" value="CUT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47327:SF2">
        <property type="entry name" value="FI18240P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25057">
        <property type="entry name" value="CUT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2025"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="32"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="132"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="226"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="306"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="403"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="496"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="732"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="825"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="914"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="1088"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="1182"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="1272"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="1379"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2130"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2218"/>
            <end position="2242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2133"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2222"/>
            <end position="2242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9526182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2242" mass="255469" checksum="8F7E876E6AD00785" modified="2023-02-22" version="1">MFIIIIRYIKIIIMLPVLLSVITRALVTSDNCFGGIETFEKLAATNFESNTVPMAGVLLQQDNVALTRDCINLCRQQQRCTTFFLDYTQFRCLAYVESSRRHRDHIQTTKNSNLFEKVCLKGISRQEFDHVCGNERLWAFERVKDTFLDGFVEKELTNMVDREECAKACLIEAAFICRSAEFDEVKRICRLSKENRRTQPQAFVYVKDSQRDYIENQCAPAGPASCVYTTKMNTNVFSMDSLQFASSAEDCQLHCDREQSFNCRAYGFINNRCMLSGDDEKTIGKHPLTTMKGATYGERTCVAELCTNGIFTYEKITGHVLRSAITTPVEFPEYSSLGVTSWCRGSCDMAQLNCPAFTINYKNNRCERLDRNTQGRITDLTVSEGESFFEKICLRVPQIMSQCQDKFWAFERVLGYELAPVLYVKTLNFVQSRRDCQEYCLQEREFPCRSALYNDETTECKLSPEDRRTSPGHYYRSRNMKINYLENQCVRIHSSCPYQRTTNAYPTYTDIVETDSIASNEECEKLCNDNRYFLCRSYAYYSSNSQCFLSGDDSVSAGSSFIQHRSNIVYYERQCSKLSTFNANQSSNNGDKVHLVDTTTDEYPIPLTPLTDRIGETSTLSPGIPQLPSSSSSSLPSSLTPDLDSGNVNKEVVIINGTLGGIITTKITRFPESLLPTISPIITSSPRSMGYPGMDSPMNNDQLQSSYDSLQPENVDQMNTRFPINYSSNKKCAPNSRFLFEKVTSFEPIGGHLTLLYTDLQNPGIVTECARRCEHSSLCRAFVIDYYHQTCHGLFENSSVGLLDLRLSMGKDYFEGFCVPNFVHCDKFWPFDRIIDQAVIGARPEEVVRFVSRPECRTRCLEEKKFRCSSASYNSFTHECHLYSETRDSGSLNLQFSKGIDFMENQCVIDVKSCRYHSIERDISIVSVTKSVRGTSTFHCEQACDYEREFNCRSYTYLDNPDGSLVPGGNLCLLSADNRATSHQGSIQFRPRALYAEKDCLYQKSFRPNQEQNTLNQQHHLEPTSLIGPIINYASEPEGLTARRIDPTTPKPNIVHKTHMINQSRFNSDDLQPTVNNMVQLQHIPHRCSLDEYTFEKTFGYDLRYAQRERAPIVSRSGVVNYCKDECIRRGDRCMAFIIEYGSDKNQNCFFLSEAASENRNQLNKLMGTTYNEKICLREKTCDSIWTFERIIGYTMDETADREINSIMFRTACQDLCLLEKSFSCRSLTYDYGRRICRLYHNTRRSKPQSFQRTSDHVDYFENKCTKELSTCQYRDFKDRRSNYVDKLSIAATLVDCQRQCDSEYSFHCKSVNYNAITQDCALSSEDSLSMLNVANNDDIKTTSPIAVSEVVSAASTITEYLHGSIYSEKGNCEQVSVQCNQEDMMLTLNFDSPFMGRVYTKSNPSECFINGNGQLQLQFAIPLDSRCGTYQESTSSYVNEVIVQQHSVIMTDNDRTIRVLCSFEVSDQTITLGNIEQQQQQQKNVPIPNGIDVSTNPNGRSYKDRKSPATFVANTAAPPSIQMRILDPSGRDAQVVSLGDDLILRIELRDQNYSPYAIFARNLYARSSNGESLFLIDNNGCPIDSSIFPALQLDPIDHRSLYSKFKAFRFPSTGVVNFEVQIRFCQEYCEPVKCAQLNGHVDSFGRRRRRSVNSFQELFLHQQPSLKWHSNRINMNDGDNNKKHLNQSQENWTRINLSTNHHGLLNMDQINQSSLKPGNNWTATNEFVQRIRIGFTYPTNNYRYYRNRNNHSIGHDVGDAKKTDEFNIIDEYGNQIFTTPAMHLSGNVNINELDENIDNGNVDSPTTTTTTTIESYIVGSYSKDRTMNDMHNVNSNENENITDNINIATTTTMKMENFNPIVTNAALPLPTSNLAAEVPLSLAIMVDGNVDDDKDNDSIANAAAVTSVHDDDMKMMTTMTILIRRLIMNSIQDDEIHGQNKERENNFNLDMATNDLGHHHHRLRQQNNLKYVDMAAAAIRTTRHGHLETRNNLGAIKHDKTKATTKMKENLPLICMDYCTNTGIIIFITTLIVTIVHLTLGASVYLYITKLKQSKKFIHHHNHVNRKNLMFIRNVVGAPANYQLSNSSSIGFNHCLSPNSTLAYSRNDDCSSLNEDTLTPNAVLAVIDDHDDDHNDSSNRFNDEYTNKTNKQSEQKPLSWFGIDDHQQQQQQHQQQQQNKQQNFGSIRSTFNHGNIFFSGPREQRFFGINNYQFPNHRSSDLNSSSCTTTSTSSLGSTMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA34</accession>
    <name>A0A922LA34_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA34"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006631">
        <property type="entry name" value="DM4_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07841">
        <property type="entry name" value="DM4_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="351" mass="39950" checksum="E9D708ADEB5A158F" modified="2023-02-22" version="1">MLKPISGSNYWIVLAIIVGLTTTLILLPMNAEAASSHRYRRQTDSSSTALTTASSSNAMITLSNLILPTIRAIIQAPVRLIQELISEIRLFLSSHNFTEMLDAKFLRTLLQRLPERIGHYWLTFVEMENECIQRTLCDVADFTTHHVPHWVKQILLIYFTTFNQNVYFEAINNGLIAHNCQAKFSQCDPNSFLSRLSNNMSQSIHTTVEPIRVAFSEFVNVTVSALDSMASTTEPSIHPKPIQETNFIQNGNTADEFEEEFDLNERSGFISTKTEHANNQTRLDNVHQDQPMHAMDQHHNAFASNHQQPPQVIRPPPAGWSPAMSVNRQPQYYQHMIQSSQPMMIQPQQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA73</accession>
    <name>A0A922LA73_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_003060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045217">
        <property type="term" value="P:cell-cell junction maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053243">
        <property type="entry name" value="SJ_maturation_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653:SF1">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47653">
        <property type="entry name" value="PROTEIN BARK BEETLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="516"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="1490"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="7">
        <location>
            <begin position="2450"/>
            <end position="2537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2928"/>
            <end position="2947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="3589"/>
            <end position="3622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="3642"/>
            <end position="3679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2931"/>
            <end position="2942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="3593"/>
            <end position="3607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="3658"/>
            <end position="3671"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1560"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="2527"/>
            <end position="2537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9529166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="3862" mass="439994" checksum="70AA28C4F51475EC" modified="2023-02-22" version="1">MSSSPSTTTTTKTTAKPSTIPTIANIRPCVSADHRHSFHDDGHLQHQTSCFFRQQSSSPVNNEIRHYDDYDYFNAKQSTNKIQIKKFNLKHRNNKINDCSTTKNDNTFNSSKKLPSSLMNTVKKTNTVPQTAIPQLFLPSQSSASTLRSSRRCGNNNPISSQHYNLSNCPDHDSFVTTTTTHASMIIETISNKNDDNNHRLDKFVSKKLKNRQKSTTNIMKQVHEFQSKSNFFNLQSIRSQNHYPSIDRKIYMDSQQKFCKIFHHSSIKKLNMTDKQIFNHSHENTIMSAPSVKLKHCYCSYVFENNLNNTTYSHWLRQPQQSILSKLFFISILLLLSSTQFLNIIIPVISAQSLQQQSSKHYSRYYPPYVIESQSQQQNQNQNQPSSFNQRQGRINDYDDQNKLSSTFDGGEIFGQKILAKQSSYRHDDYTTAKNQKADYEIRSNILIHQNSHLIIEPGVRLAFSPGIGIIVHGSLNATGTSTSKIILTISNGATKLPMINAEGIHHQKPLWPNIRLVDGQRVEQGRLQLKYKGHWHSVCTNSRNWTRNDVEVVCHQLGFTGGHWYRWFKRNNDSRQFMLENPGCHGNEPTVQDCQNWSQRRIGSGVCDFHQDIGISCDNNQDSRNHWRGIEFINSDSRVTSIMSNKMDSRRSNSAIEHVIIEYAGQQSDGKLLPALSSIGSVPPHINHLAIYRSAYTALNITDPINGFEIMNSKFIENRAYGVYVNTSTGRVHLSSVEIEDNGADGVRFVHFDKTDYSSDNFCETPNLGTSQVFPIKYTYRQSASKAPTEECCQEFYSKDWEGQRITVHFPLLMSGVEDYGALNEYLVQPYIPHVGREGSIYIIDGHSGRIIADFFIRNNTKIQSVSSIIGNGPLRICYRPAHYRRVLFTIQVVVDYGREYDVTLSNSRIVANNGRGLWFQDLRSGAVVNRTLISNHDYVAGLNIDRGVGTIIVNNSIISNNIADGVNITNGGGYLHIDRTEIVNNTGRGIAVWFNESINLGAFNYSSHVTRCSVSNNQIGLLIFSGCHFSSTLWHQGAYWNISLNDFFDQREQGLLYHSCIPRPRILKMQLKPLVTNISIGHNRFLSNELHAIHVAPLFFTKLNIAHNEFSGHKKAVLYINSQDHFCVQQFVEDAERFPFSFFNGNANNNDGGHTLMNQRSLALDLWPTVVRIRNNNFHNNRGYYVASIGLLEPESSINVNFSSLSQKILFTRNILHDNIIREPFENLNSRSRVAAVLCVTSSNVLIWRNEFINPSSKYELGVHLGVQYRLVNASLNYWGTSSSSISMRMNFGEYHADKHLDSAAEVYERIFDRKNRYNLAQVEFLPYILIPNALESDRSALSLINDREKILQFFHGNPTGEIGGQVKGQVNLRSGKYFVKHDIYISPEGELVLNPGTVLHFDQSVGIFVQGKFKAKGHKKSDIKFLLASHKSSNYRSKRNVTLPIEVASVINSTMAKFNNRSIAALDQKSPVSFKLKQTSYYSQNIRLSNGTEGLLEVKIGNDWGTVCGYNFDIEDASVACHQLGLVLNERDWRLEKSEFWNSKNSRIILLTNVQCTHLDTDLTKCKAERMSNNDFEGGWCPKGEVGIRCFPEAWAGIRFGMLTQEVILEHITVEKAGLIDYRTRKFGPALQFDFNRFAIRDSIITSNIDSGVGILWNDVISEPNDDRLLTIIDTKIMGNLNHGIVTSTQGIRIENCLIADNKVSGFHYEPNFRREKQEELASWIVKQPIHNRKTSVFIIIPGETASDQSIYLGDIGRQVYVYVPRRPTPISKPFHLLIRTDPGKRIGVMAISPIFLTRSSESLRLYSPLIDSIHASKMMWDIRRNLTTFPFIYPGYRLMLEYSTGELPYGGILLLFTPKQYLRNIPGEPSFVEKSLQEQREMNTMILVNNEFIENGKGISSAHCSMNIDLNGNYCKRYGNETIIVRNNLITKSKGAGLFVNSFAYSSMIPYSLLVNMIEFNEMPQQEYDITYASSVIAEINYTLIENRFVENAEYGSIVLYDHSLYANSDMQQVTVQSMPGFVLSNAIGANYPSNTNLFHWNIHHCTLEGNKNGGVDLKLPYTWLYNENFTHTVVVEDSNFLKNQNFEFVIGGHYARVNITRNKFLDNQCKIGLVSILGMEKLTRVVQNEMNDNYVQRYVIEMNMESHADKFGTVTAMINRNKIRNNRFSGAAIQFTNAEEMSNAYTPETYAIAIRGLQQVNVTRNILTNRNLQFELLAGVKAGSIHNELNARENFWGIGFDPQTIRERIFDFDDWNSFSTTIFSPWLSNDHSDASLVHDQSTIDALSQSSLIPQLLGGRLNQSLVLHARDRPYVVQTDLTIMPDTTLTIRPGVEIEFYPSVGILVLGDLNAIGIENKPILFRPITRNSNHSNILQPKMMNSWTERSKSYGRKRQIPMTEQLVYSKSDHGGVRLCLTETCDPETEIKAEEKMKHQLSWFADSGYPKLASNDRRRHGFMEIYNLTTLQWTPICDPRFTERDAQVVCRQLGFSTLNVFVRRASRSDMDPTLITRVSEWPESLECKGSESNLAECDLRTFSKDSYDRKSTLFENAPLYHSKLLSTNFYRKTHQNQIVDNQTQELLFYMNDDWRSLEERSLIQSTACRHDGDEFVYIFCGEDNNRFNKDDSQLFEHWGGIRFALPEFEEDDSKKFLANNNNNNRKQFQKSAMHYVNIIGAGVLHGEKNAAVQMIQRSIPLEFVTIQNSAYHAVETLAPPESLKIHRLRAENNLGAGLNLLLSGTSTSESSRVPYEPITDGSVFTVPYNAFSMVDICDARKQLRVKEKIIVYYKYDNRPVDCVKIFTSANPLKNIGIRFLQLNLWSKFTETAGKVNTFEEDYIQGKKFAYQTEDIFHNKIHELIDETTDSYVDASLITSMSDSIMIWDGDIFNETTRHLIGEVYSDSTQEFLKRTSINPLWPKTLSRQRRYTTSTRRPPLTTNGPESSAKNILYKSTGFSMSLQLHVSGASGRYGFIAEVTTLPSAYHDERDIQHNITFSDINDNNAGALLYQSVGESVPQLALLNNMFKRNCRNLWGNFSTCEGQTIDLKIQNSPHLYFQNNLITDNRAGGLKISATSFTAVSALNAHLINNLFADNYQKEALYFEGANSYQKVDVDRNYFSRNRSPHRSNMVFGRAIVEFHENVIINNYGDNQLFMAGFAHAQSSSKLQRCTKNFFYNNHAKNERGEQSTIIVSTIGQIYSDNYLVNPDNDFELSTRNRTIINAATYSLKQNLIEPTSFAAVLASAIVQAPYNWWGFNETSAIEARIRDSRDSFYLIPVQFEPFYSGNWSVLSGSCYGGYQKIADTCFVYVGGRMTYDLARKFCGKDNSSMPFIRASNQEELMHYIYLQQPLFNRRRHPVWVQSFDVPIGSCSVLIDGHVRVHDCNDELPFLCERDPEIGISTATLDYWYQEPLGMAVIGISFLTMLLTMACICCWICKSRHRHLEKLERRNSIRASIRSSRSLASMSALNDSQYFTNRKLLSESNPNVNGSINGSINPSYRPIPLHSASGHQRQSQSMQQDHYGESLSSTFPIYTSDHNERLVLAQKRYDDAFKYGQNSRTSNTDIMRSANLQQPTFDMVYDNRAFKQGPTDQSTPMMSPLSFSSREEHHNPTLRTWTPETNSTLDFKVKPALDPQELSQYTESSEDLHKPPPSTSSSTASDLPSPTSGQLSNRPRFYQPRLQQSTMMKSQPIHPPPPPPIRRLIQSRDQRNENRQRRSMDPTMFLHHEDEEPSISHENKDMPMETTFDGELLTFDHHQNEIHNRKEFKKPIYHQTDLDGVNTNYHMGGSQPSLTYGSYAPSTIESESNNPYLETSLDNDSFHGNNFPAIANSKHNISSSTNAATKARLYASQPLETSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAB8</accession>
    <name>A0A922LAB8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Exocyst complex component 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EXOC1</name>
        <name evidence="8" type="ORF">DERF_003192</name>
        <name evidence="7" type="ORF">HUG17_5198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAB8"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="544"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7642153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9529301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="896" mass="105652" checksum="1BE08D5EB1939C53" modified="2023-02-22" version="1">MTSIQQQQQQIINRELFQLNSERLKYLIIVNKPNKKKSKSNYFLAIVVNNINTHFLYLIKKTDQSYKKDKIWQFDEIQQIDSKHESNEPEFEIRFKNKQEFRWIANSQKEKSSFLQSIKQIVNQVPAYFHIKFINISNGQPASALVFNQLEEISTNEKLENGDWNQENDSYQALTNREEADLERLFQLEVENPINNAEALTEKLSRDLANMDSLNIQDIMASEQRVMDLMTILQNTIDETFRLENKIIYYESLLKNVRDIVQKVEKKEAIVQTYNDNNKRLLDEFGQLVTKLDFAKEDEYLLKEYDFNSIASYGRCIEAAMRLQEAIQFEISPTLNSLQGVTEQKRYLNGIASKFLEKLMDQFRSIMTNLSNEYLERSNVMKGNEQVLTEHSKVHNQLFGYGEFIKWIRVFDPKSYASLIVFYTNTFSIVYEKEFSYFFDYLRDRYVYNSKGIGQSSEISKRKSLAINDLKTDFRRGSYASSSNNETTIDNVSIRSSEVSLSEWEEFDSYIEFLLKSIDPVCLVEQHFCNKFFDLDNQNISIPSTPTMTNKSSPSETDVSNHSSSVSEQSMQSKKQDKLRSILAELFKSFENEFISFISHYDKIDGLYSMYFLVRLTSHVLNAQDAGSFLSKAYGNILIQVKRNFDRYMQSIQTEIEEAKDPKRTKIGVLSFVKRFENFAKQTENIIKYGQRRTDIDRWYGILLEKIFHSISRIAKEHQRIYKTPSQIIEIENYHYLQIMLSSLKIACLNNEKKVAKDYYNNALKEYVNINFRRPLEKLNIFFEGVQQKVKQGIKEEEIGYQLAFSKQELRKVIKECNLKDIKKGLEEMYRRVEKHVSDPESTLIQVIWRSMQEEFITQYKYIQEMIKKCYPESNICLMFTIDHVLNIFSEIAQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAI3</accession>
    <name>A0A922LAI3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nck-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NCKAP1</name>
        <name evidence="2" type="ORF">DERF_004798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEM-1/HEM-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAI3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019137">
        <property type="entry name" value="Nck-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093:SF10">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROTEIN HEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12093">
        <property type="entry name" value="NCK-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09735">
        <property type="entry name" value="Nckap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1174" mass="136363" checksum="E46D87F6BAB934E9" modified="2023-02-22" version="1">MRSITISHHKLAEKLTILNDRGIGMLTRIYNIKKTCSDPKLKPQFLLDKSMESIIKHAVRKFPVISDYKSNSQFAVLSQIKENITKSLQLYYLTFVDLLDFKDHVCELLTTMDACQVSLDIRCNFDLTKAYLDLIVTYVSLMILLSRVEDRKAVLGLYNIAFDMINGHTDSHFPRLGQMIVDYEQPIKKLSEEFVPHSKLLQQALISLSEQFLARNITAVDWRNEQLFSLTAKPEQMLNPALTSTTQCLYMSMDAMERYIIFGFLLIHQFLNQQETQRLFMSALKYGWVIVLFRDEILHTHQFVQQYFETHKGYNKRISEVKDTFNHVISKGPHFHRERRKYLRTALKELSLLLSDQPGLLGPKALFVFMALSFARDEVYWLLRHYENPPSRQSGKSKVSPEDLIDRQLPELLFYIEELRGLVRKYSQVIQRYHIQYLYNYDAHLLNEILKNSPTLPEDDCIILDSIHATISNLNESQLESQIFDFRPLRLDWFRLQTYTSISRYPFLITENHNLAQCMNTIVYHTKMIDYLDQMLTETSDLSIFCFCNRSFEDQFRMCLEFPAQTRYIIAFPLICSHFLNCVHELCPEERYHIGDRSINLVNLFLEEMSKEAKNIITTICDEHCIMSDMLMPKHAKMFAEQKKLKQKGARGNAANGPQDPRLVANGLGPNNMYVIKPGTESYRRSREELTTMDKLHMALTELCYAINHTSSIHVWDHTFSPREYLTQNLENRFNKSLVNMTMYNEQTKEIAKPSELLISVRAYMNVLQSIESHVHIDMTRVFNNIMLQQTQTQDSHGDKTITFLYTNWYLEVLLRKVSTDHIVYSPRQKAFVSLVIDPQMPFSAEEYSDINGSNLECQCSVYSFCSVYSIELRALVELIGSYGIDSLTEKIMWHIASQVTELKRIVNRNVETLIELRSHYDQPEQMRELVKKLTDVDSVLKRMTIIGEMMCFRSLLQEALNDVLEERIPFLLGSIKDFHHSANSSMIELMHLDNNNVIKAVDEMASSAGIECKVDSSLVNALRNQKNDIKPEEKYQYACLLMVFIAVSLPKLARMENSIYRPELEAHANNIHCLAKAINGIAGALFTITDTNDIEERLKEFLALASSSLLRLGQETGDKEAIRNRESVYILLDLIVQESPFLTMDLLESCFPYALIRNAYHEVYKHISVNNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAQ4</accession>
    <name>A0A922LAQ4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAQ4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8599" checksum="C383B51AEA6B6B16" modified="2023-02-22" version="1" fragment="single">RLEKKINVIENDNIYNYNLLANGVEIETFDFCVADETFEISESIVLMMMMMISVYLFNVHSKVNDNQLKTVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAS8</accession>
    <name>A0A922LAS8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apoptosis inhibitor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">API5_1</name>
        <name evidence="4" type="ORF">DERF_002735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the API5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAS8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008383">
        <property type="entry name" value="API5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758:SF19">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12758">
        <property type="entry name" value="APOPTOSIS INHIBITOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05918">
        <property type="entry name" value="API5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="528"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9528819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="543" mass="61788" checksum="76F9AD85C8710385" modified="2023-02-22" version="1">MASIDPLDQLYEHYNKLDSAKENIKQFESDYLAVLNAVHGSSQEKQFCSQFISKFFVHFPDHYESAIELLLDLCEDDDPNIRLPAIKELPNICRDRKELVTKICDVLAQLLLSEDPLELNIVNQALITLANYDIKSFLFALFVQILDGEGETRDRVVKFFGTKFRTIKPNLLTKEIEEFILENCKKILIDATKEEFITLMTLLAGLKISKTVHGHNNLLAIVKDQSELNNDFIPNSLDKFLMCVRHGIPYFSQFSPSTEFVQYICLKILPHLAQIEQQQPGLELEVLQALSEIISFVSPTLETSQFEQYQNAVFQCLLGYIPKPPEDLNTSATDLSSTDDLPSTQFSHVECLLYSLHQLCKLNPKYFEANSKANEFKDFKLRLQYLARDQNDCIESNIEYQFINKRFFRISPSYKTSIQLSFKSSKSTTTLHAAASIPTLASDKTDNCGDSSSTADPATITKKRPLITAPEGSETTSSTTVKRERKFYQPPVGKFNKTSPGSFRPRSSFSRDYNTNNQRFNQRQRRGFSGGRVGRGGGGFRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAT4</accession>
    <name>A0A922LAT4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Clusterin-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLUAP1</name>
        <name evidence="9" type="ORF">DERF_002633</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLUAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAT4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019366">
        <property type="entry name" value="Clusterin-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547">
        <property type="entry name" value="CLUSTERIN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547:SF0">
        <property type="entry name" value="CLUSTERIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10234">
        <property type="entry name" value="Cluap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="449"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="205"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9528713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="531" mass="61570" checksum="E673C015961989F7" modified="2023-02-22" version="1">MASSNYHLMRNFISVMRSLGYPRQMSIENFRNPNFPLMADVLVYLLKRFDPKTEIETNVETEEGRLKFVMTASHLMVNKANLDINVKKLYMADVNSVQEMIKLAKLIQEAWITLDQDYRKQGRKDVINEEDENDSDESKQSLIVRNGEEFDRTKLSQYNSFKTSQITSEIYQVATKLYDTIAEHDQNKDQLQKTLGKQLVIDQIESQIRQSIRQLQQDIVDMQQRKQNVDRDNDDINGKIEKKQSELNRNKKRLQTLHAQRPGYQDELEKIEQEIVGLYDDYVTSSRCLYFLEQKLEEFEELERLKIEERNKEIKQMLEQIKIDDFLKTNKDMRINSWNQQNIGTDERSADELAAIVDVDEDAMGRVSDGSDFSDRDINEIPKNDNHKSRRNGRQKANKLSRTNDKKDRLLMANTVVKSQRSPVSISNDNTLDTSNNRSAKTARIFSYGSLLENDDDDDDDDDDDSERSEANAKMSDSEIDLDAIDSEDDDEDSINSTEVDFTKSNETTKIATNSEIKISASNLDKGDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LB16</accession>
    <name>A0A922LB16_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_005260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LB16"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9521620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="71" mass="8103" checksum="89AC8BD3E2ABD5B5" modified="2023-02-22" version="1">MCIKPLTTPTKFGAYSEIIVHSPPTNVMANRHIHGINMATAWNNFLVVNTDIFKRSIIQFDMYGAMKHDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HF73</accession>
    <name>A0A922HF73_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Insulin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_015795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HF73"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Insulin-like" evidence="4">
        <location>
            <begin position="280"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9491059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="463" mass="53368" checksum="5B53C2C3F3448978" modified="2023-02-22" version="1">MNRLDLKLNLIDHHHHYHQNRDHHHHHGLLSSNSTTPVGLLIRSCSDLLQSILINSNNNDESNDEENKIKMDQSSSVIEHTNSMKFFCKSVPSLQTKKTKNNIITFKKQRSFSSSSVLLSSPLSPSLLMNNIETAVKDNCHIMNKRFIRSSSCNNWPAKLLQPMHINNNNNKKVKTLPNRCMALAYGNKKYRSSSSILTIVMLITVIVSIWSSTNKTNMSTVCAASAGIEVGNGNENESPGGGHINIVDDEENRSLHEWDDIFHSRSADDWRQLWHRERHRRCRHDLLAHMELVCQKDIYKLNRRRKKRTNVNDDFYQHETNGKLSLGNLDNNNNSDGKSKNRYLTFIEANTFAQKQLKRFLRKNHHYDNYQSDMDVIHQPYIQMAKKLFDDDNPSSDNQNNSNNNHDHINNDYDNVGGSGLMAVRRRQRGKRGISDECCHGTDGCSWEEYAEYCPANVRLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HH09</accession>
    <name>A0A922HH09_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HH09"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="91" mass="10204" checksum="33C29088AC2478D1" modified="2023-02-22" version="1">MILIPNGLSPLSVDNCLSDSNNTADLARNFWMLRNSFCLAPLVILRCSKSCSVIFIISSYDIWANIDAYLCRQFSPHTKSESELIINSCDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HHG5</accession>
    <name>A0A922HHG5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HHG5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="76" mass="8115" checksum="E5ECDECC26D73AE8" modified="2023-02-22" version="1">MSSTTSSRPPKSSKRTLGSTRYLCRKAACLTNVASMSRSILSSIVRDRLIDKLVDEIGVSASAGSLLLIAAAMKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HIB4</accession>
    <name>A0A922HIB4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HIB4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="76" mass="8031" checksum="FDFD92A986632815" modified="2023-02-22" version="1">MDITINIYEYLPDADADADADADVDDDDLSTTTKTTTCTLSSSSLLEQTNKLFIASCLDNAAAVVIGNDGDVINLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLI8</accession>
    <name>A0A922HLI8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein PTHB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BBS9</name>
        <name evidence="2" type="ORF">DERF_013262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HLI8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028073">
        <property type="entry name" value="PHTB1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026511">
        <property type="entry name" value="PTHB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991">
        <property type="entry name" value="PARATHYROID HORMONE-RESPONSIVE B1 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991:SF0">
        <property type="entry name" value="PROTEIN PTHB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14727">
        <property type="entry name" value="PHTB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTHB1 N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="431" mass="49101" checksum="E17DD46877D409BF" modified="2023-02-22" version="1">MTLFHLREFWTTNLGNDEEFDKCSICVSNIDNEPDGFDKIIIGSFNGILRVFKIILNNDAIKNEQNLFQISDLLLEVDFKNPILQIASGYLLNSANVQLAILHPNKLCVYSISSTTGVTDHGTSYNILLIYELKFNHKATNMLIGPLGQTKGNDIICVQNMESMFEFYENETFSFGYHWNRTGSIRFPMEFTYIPNRDLIVLVDELYAIQCYQYQELAMNSTTNVQNEDGRKVSVSDWSYAFGEPIIDIQTVKLDKWYVVILGEKNLCILRDNGTLFFVKKFDANPSCLCAFANDQKDSIITLIGTQMSNMLVYQNDILRWATKIPFIPVAIRRANLNDIAGSIVLLSDQGQLTVGYLGTNPSLRIIALPSLADSQNNEKIEEELRELKKIINFEQTNNNPAERDNRLANAINLNLIECHKESCGQFDHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HM80</accession>
    <name>A0A922HM80_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_014095</name>
        <name evidence="9" type="ORF">HUG17_4041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7640008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HM80"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7640008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9493343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="219" mass="25120" checksum="31E454A62F4103BE" modified="2023-02-22" version="1">MQGQPQEPDMPSFKCLLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLLFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIKGECAIIMFDVASRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGDPNLEFVAMPALAPPEVRMDEEWQRKLEDDMLKAQNTALPDDDDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMH1</accession>
    <name>A0A922HMH1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMH1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="62" mass="7349" checksum="277F5BF0B1B32F76" modified="2023-02-22" version="1">MKITKTEPLIQTICIVITKHLFIYSNETMMMMTMMIEIMNHYLLVGLVGWFIDIMAIGYFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMI3</accession>
    <name>A0A922HMI3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_013596</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMI3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18416">
        <property type="entry name" value="BTB_Shaw-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000020">
        <property type="entry name" value="Potassium voltage-gated channel protein Shaw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF252">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="BTB" evidence="9">
        <location>
            <begin position="85"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9497619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="434" mass="49256" checksum="1A729823DA473458" modified="2023-02-22" version="1">MFARGLIPTGTGGSIATSGGGNLMMTGTGGHHHHHHHHHPHHHHGGGGGGFYTSNGFTGTGTGSIGTYGASNSGGGGSSSITENNRVILNVGGIRFETYKTTLRKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPTNVCGPLFEEELEFWGLDANQVEPCCWMTYTCHRDTQQTLAILDTLDMDAASLTEEEMSKKFGYEEQYHKGKLTRWQRLKPKIWLLFDEPYSSNAAKGVAIISVFFICVSIFSFCIKTHPNMRVPVIYNRTIKQPPNFRPPYSRYSSIPYEQHKQQQEQQEYSIHPNHHRQRHHHHNNHHKQRQRPSYPHKSSSSSTIAQSSSSSSFSDNKQSDINIDDNNENEDFDDNESKSSSSSSKTWKESWTLDKHKTDAHDAFFYIESICNAWFSFEIATRFLVSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMN0</accession>
    <name>A0A922HMN0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">G-protein coupled receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ser-2</name>
        <name evidence="15" type="ORF">DERF_013645</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMN0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004989">
        <property type="term" value="F:octopamine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002002">
        <property type="entry name" value="Octopmn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF174">
        <property type="entry name" value="TYRAMINE_OCTOPAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00664">
        <property type="entry name" value="OCTOPAMINER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="874"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="348"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="250"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="528"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="582"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="649"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="724"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9497679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="892" mass="101017" checksum="D801979AD305B869" modified="2023-02-22" version="1">MLNTGVGSTSSSTAGNFHHHHHYHHHNYYHQYSPITTTAATTTTTEAAINHNNIWPESPSASSTNFIQTSSSLPPTTSIFLHNPQTYGQYYYQMPTLSSSSTATTKTTATSTTTNSQQQPQQYSTNSYLPSLTLAILLMSSSTLAPFLSSSSFPSSSSMFSSRNNNNHHIRRSATTIQQSSGPSSSSSLSNQFDLPYYSTNSFSIPSSSMPTLPPFSNLIIKNESQSSTTLFITQTPLLLPLDYHHQTITKNENDDNNRFDYDDNIDDYDDDDDVDEDENILAKISNDDNDDIDVEDYSDDDVDDNKNSSIFEQQQQQQSSLSMDNNYTNSITITIILAIITIFTIVGNLMVIYAIFNYRPLHNVQNMFMVSLAVADIAVAVLVMPFNLAYSLLDRWIFGLHLCEMWLTSDVLCCTASDRYQAIHDPINYAQKTYNASCLYIYLYVWILSAIISIPPLIGWNDWPEEFNEETPCKLSEEKSYVIYSSMGSFYIPLFIMTVVYFKIFQATRRRLKDRAKASAIANLGNSSSQPLAPATKSNNTNNNTTKIVSSYEDSSSSTSPKSSYMKTRRYLRCCFEHHRNDHHRSNNDKSMNENNNNNNNSNNGKNKKLRFSRKILKETRIEIESASDDHSRVSSSDAYGITSNVPATYHHDSFSNEDDFDDGNDFDEDDDDNKSIDADIPIGEFEINNRVSNNNGDDDDDEQEQNSENSEMKKSASTSITNQHQHQQQQNSSPNKVFQMESTSINNSAIIIQSDKNLLPSNNNNETTFVIANDIKQQQQQQQLDRRKDNEISQQQQQQQQMIVASSTILNNNNQSSCNVSQQQQSNNNNSTIATKIEQQQQHHRHNMKPLPVSVKKIWEEKQKISLSRERRATRILGIIMGVFVACWYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNC7</accession>
    <name>A0A922HNC7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_013864</name>
        <name evidence="4" type="ORF">HUG17_0810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNC7"/>
    <dbReference type="OrthoDB" id="420022at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000088">
        <property type="entry name" value="Histone H3-like centromeric protein CSE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="3">
        <location>
            <begin position="42"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7645272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9497931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="134" mass="15650" checksum="2974093B8F77C7AD" modified="2023-02-22" version="1">MARHSQNSRRISEPTTPGKSRILRSSLQHSTKSPTQKRRYRPGTVALREIRRYQNSSHNLIPRISFQRLIREIAQSMKNSLRFQPAALEALQEAAESYLVRMFEDANLCAIHARRVTIMPRDINLARRIRGDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNX6</accession>
    <name>A0A922HNX6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNX6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="114" mass="13280" checksum="B7EB4FBC36FFD2D5" modified="2023-02-22" version="1">MKNDTTILGRIYVAEMIIIIYDDDNDDSGMVIMDEKQHNGSFDKIKSFPIYLIGSDFGNGNKKKHWKRIGKKLILFFCWKPQNCSICDIRYYGTIDTIDDCVCVPYSRSYFDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP44</accession>
    <name>A0A922HP44_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP44"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7651" checksum="2FD97F83262F0939" modified="2023-02-22" version="1" fragment="single">MKEKLTFFSHILFIYYCQVLMKLKESDHSHHTIIILFFLLIVHRHVNLYGIIIAVVDDHDQIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPN7</accession>
    <name>A0A922HPN7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AIMP2 thioredoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_013206</name>
        <name evidence="2" type="ORF">HUG17_6156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPN7"/>
    <dbReference type="OrthoDB" id="6503964at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041503">
        <property type="entry name" value="AIMP2_thioredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18569">
        <property type="entry name" value="Thioredoxin_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIMP2 thioredoxin-like" evidence="1">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7643794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="328" mass="38379" checksum="9A3525D14BE56D65" modified="2023-02-22" version="1">MYAITPVYKSIHHFDSNVIQTSMYSMKPYYSGIMENDQQQLSSSSIDLPSGPLPIPTDLDLEKDHDARMALEDLLSRQMLLLCRLNDLERKLIDVNDIQIKQEKFVSKLLKPLTENYEDIVIHFDLDHPPTTLLTVLSFMIKDSPELFLINYHVHSSLHGCSSIIVKQFQMKQQDLNAKLEQINFRFNTLQDNSDRLKRKIIIKFIAKKFYDDNNQMEAIFKSNQPSIKGELNIIQHLCLMISANDSNECDELWKLLQPPNDIQSDRYCIEKLGRYFMGLGERRFFFNHPQPQLIDIIIWSLANRSRALRSLMDAKWYKVIESMLMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQL5</accession>
    <name>A0A922HQL5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EIF3H</name>
        <name evidence="8" type="ORF">DERF_013842</name>
        <name evidence="7" type="ORF">HUG17_0834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
            <tissue evidence="7">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7645296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQL5"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="33"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH7645296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9497898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="339" mass="39294" checksum="4A75E046DD7DD78F" modified="2023-02-22" version="1">MYSHNYRRSQQHHHHQQQQQHKQGPKESPIKCVYIDGLVVLKIIKHCHEEGSSSEAQGVLLGLVFDNVLEVTNCFPFPRSNDDEDNEEAAEYQYTMIRYLKNVNVDHLQVGWYQCSPYGSQLNKIETIDSQYMYQGTIEESIVLLFDPIRAQRGFLSLKAYRLTKAAMNLCKESDFKPETLRQNKMSFEKFFEEIPIIIRNSHLCKALLLEIDEDMPIDAGRQLLDIGGFSVVEKSLQSHIKSVEDLNKQTSTLRNQIIKQHEIARENMNRSLAKMPPMTEDEMAKLLKSFKLTPLQHLENLLNYSQTHNFCQQSSLYSTQNIGKLFMAKALHNNNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQM6</accession>
    <name>A0A922HQM6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial inner membrane protein oxa1l</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">OXA1L</name>
        <name evidence="12" type="ORF">DERF_010619</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQM6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="11">
        <location>
            <begin position="162"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9505848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="431" mass="48453" checksum="522E67846718DAD3" modified="2023-02-22" version="1">MRSILILRTVSSVFNRNGWKNVDKFSSSSLFLSDRNLNHCRPSSSSNVRTFSSSGILNVSLLRSHDKLCFMRKSLIFHPRFNSTTAKTTATAAATTTNNNVASENVIDLTAIDVQKSPLLDNEFISNAVLETSVASLNLGSNYTPVGWCVNYLDFLHSVFPWWGAIAVGTIILRLCLFPLVVSAQKSAAKLNELLPEQAILKEKMNQARISGDSIEFARLSQESMSLYKRKGVNPFKTMLAPFAQAPVFITFFITLRRMANYPVESLKTGGLFWFTDLSVSDPLFALPVITCATLWLTLETSFRSGLNPNQTPLIKYGARVIPLITLAFTFNFPSAILMYWCTNNFISLIQVNLLKVTQVRSFLNIPQIKVKPQQLDVNKKSFTQHFRETMDNAKIKRIMEERNSLDEINFKKAGVGPLQKTFKHDPTARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQX5</accession>
    <name>A0A922HQX5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_011942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQX5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="814"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="896"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="937"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1268" mass="151327" checksum="B4A8CD11265B2E2C" modified="2023-02-22" version="1">MSTILKLIRKNLSLELIRHKYDGKIFELLYNDFDVLKWYNFRMNFSLWDYVNHCITKTIRSFKPAIMITSILWMAMFATIIMIIYPSNSVLIDLAIYEKMLNSNRGDLILIQIVVTFIILELLWIVFLIELLTYCSPLLLFLTIYLPNYERKMDVKMRKILIKFQAFSNFAVTFSYLNVIAIMTIIGVIVPFLCFELYMKSQINFIKFFTSIPFVIIMDMAIIFITERIKRLHNVSVLLIHYSHYSMERMFTNQFCHKYIILYSEIYRINQTAKTVLFALETISKSAIMIAAVFYSRQTKMSIVNTLFIFLMLLIFVFMNFVYSKIACIPSYNERCVQNLLHWLIRSQFHSKFKQIIRWRQSMKANLFVQAMANNRIGFTCGPLFHINKYKFFEMLLMNISWILLFHKQIKNLNLELIRHKYNGKIFELLYEDFKVFKWFNFRMNFSLFDYENRCLSKNFATFKPTIWLTSISWMTIFLSIFMIIYPSNSVLIDLTIYEKMLNSNRSDLILIQIVVTCIILELLWIVFLIELLTYRSQLLSFLTIDMPNYEHKIDIKMRQILIRFQAFANFAITFSYLYVIAIMTIIGVIVSFLCFGLYMKNQINFIKFFTSIPFVHIIDVVIIFITGQLFVSGKWAYFSLIFFKERIKRLHSISLSLIHYSHCSMERIFTNRFCHKYISLYSQIYRLNQTSKIILFALETLSKSAIMIAVVFYSRQTEISIVNTMFIFLLLLTFVFVNVAYSKIACLPSYNERCVQNLHHWLIRSQFHSKFKPIKRWRQSMKANLFVQAMVNNRFGFTCGPLFHINKYKFFELLLMNISWIILFHKQIILNMSLIFKIFKQNLSLLLPMQNHNEIITRMFNEELISTILLTFRLNFPLSDYYYHRVSINFKTFKPAFVITTISWLTISLFSSMIFFPNNQLLITTKHYEEMFKTPALNLLFSQLVIMFMILEYLSFFYMKETLMYRCSLIDLLAVDIPVQEKKFTTKMRQNLIKLFVLINFITTITYLNLIILMFTIGILMNYLYLPFYLDNRITMIQFSTCFLLSMLLVMKVISLAFQLCTSAKLFLLYLLFFTFRIKQLYRISFSIIIASLHSSYLAKKRFWFKFFHEYIILYDRIVRLNRSVKVALLIIELINKSFIISGCVFYSKQTGMSVVNAIFIMCAILTFILTNFAYSRIARIPEYNRKSAQNLLQWLSRSQFHNTKVNVSIKRIIELRQIIKSNLFVQTMTNNQLGFTCGHLFYITKYKYNELILMNISLILMFYKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRN3</accession>
    <name>A0A922HRN3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_013486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRN3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="483" mass="53510" checksum="59AAEFD341F93D8F" modified="2023-02-22" version="1">MLNMKTYVCTGYNKAGTVSANVTLTVLRRLEVTAAAYSGQEVAGIVIGALFIFLLILISIFSVVLRSRKLLHFRTTTTTNNGQSTNSNANSNQTILGSTTVTSNNNNSYHNGANGRILNGHIQTTTTTTPTTVSIPNGTLKRNSSGNANNNHIDNNSSNHILSTATNKNMTNNESNKMNKANLIVAMNHNDDSMKTNNNNSLVHHQYVVMPDNNQIKNSNNDKINIINNQLAEQIEMCDYSSVNTAENVNNNNNQFINQQQLPMSMSIDMKNLTQASCTGGGIRTALYGNHNNVKFSPQERFFHSGHKSPVIFNQQYDDAIISKRNINPNSPFNVKIGTMCNMRSTNPYNTLDSHYNHIQTATIGHHNPSHSMNNNSANIHFNPYTADVNGHHHEIAFFESTIANAHSGGSLLTTTAKNPYGQIQPTTRFSYDVRNNEQMLMNRRIDSSSPYSELILQNMINQNNHSLFDHQRHVAASVAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSA6</accession>
    <name>A0A922HSA6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein bicaudal C 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BICC1_2</name>
        <name evidence="5" type="ORF">DERF_012649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSA6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22421">
        <property type="entry name" value="KH-I_BICC1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047554">
        <property type="entry name" value="BICC1_KH-I_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF69">
        <property type="entry name" value="PROTEIN BICAUDAL C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="139"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="297"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9501838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="700" mass="78268" checksum="F8F816A106A2DF52" modified="2023-02-22" version="1">MPTTSSISSSMLVGSKSNSSSLITTTMITDSSPNTSNSSSSSSSSNGSLESDSLFYEKDLKVDKKILAIMNQGGNDYHPSLSQFLSRISIETNCHVDVSNSLRDRQGNEIPVLKVRACSQKSLEVASALIMERLDPHRDKMTFNIDVPYNDHSYIIGKDGTRIKQLSRMTGCHIHLPDCNKTSNKKSNKLSIAGTDFTAIDKARDQIRKSLPLNIGFKAQIKSGKFVIIDTASAEVQAVKRKYRVDVTFTNVIADTRNPEVTINVKGGRAQLEEIESATRELYQFVTEEKLTNDSHVMFAITIDVSHSHHQYVKGKNNCNLKVIHQRSGAMIIFPSHESNCNQVIIQSRNLLSTVMGWQELMGYLPLLLSFDINFDINGHQSQLQKLEKEFGVGIRTREKLSGHVYTVLIKTQERHSTYLQEIRQRILNFKYMNENNLINENKAVLTLATIDHHHHQQKQQQQQQQQQQQQELAASMALMNFAATYRNSFPPNVLQPMIDNNLKSIKSNHSNCQSVNSNGFHDQSPSCSLCQTSCLNGFLSNDTSLTSLNDSLPFCSSSSTSSFNPFNFRENFELTTGQSNAFGNKLNTFNNQMCNGLSNGGNLHTTTNNNGHQSSSLSGFVNGTIGTSSSTNHNSSWPSLVTTNGIGNNNNHIHQNNDHHHNNNNNDYYYNQLQSNFLKCSTYDETASQMKSYSSVFKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSB6</accession>
    <name>A0A922HSB6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FKBP14</name>
        <name evidence="15" type="ORF">DERF_012662</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 10"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSB6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052273">
        <property type="entry name" value="PPIase_FKBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP7/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46222:SF3">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037357281" description="peptidylprolyl isomerase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="13">
        <location>
            <begin position="50"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9501853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="216" mass="24004" checksum="D17221444E1DC9FA" modified="2023-02-22" version="1">MNSFIKNFFTILFIIGMVIADDNNGGDDVTELKIETLVKSDKCDRSAAKGDMLSMHYKGTLESGIEFDSSYKRGEPFKFQLGVGQVIKGWDEGLLGVCPGERRKLTIPSHLGYGDIGAGELIPPKSTLIFEVECLAIEDGPAPVNIFKEIDLNNDNQLSREELSDYLKKQVPEGAAGTHDLPDQDKLVEDIFQHEDRDKNGFISHEEFSGPKHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSE8</accession>
    <name>A0A922HSE8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HSE8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8447" checksum="0BDD4525188B499C" modified="2023-02-22" version="1">MNNELLISERELSKKNNSYTFDYDVCLFFVFIDGGFDRTWGHFDYVNIDDDDSNILDRIGSGFNGPLIWENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HSP0</accession>
    <name>A0A922HSP0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dumpy</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_012008</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.20.10">
        <property type="entry name" value="Plasmodium vivax P25 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22963">
        <property type="entry name" value="ENDOGLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22963:SF38">
        <property type="entry name" value="LP13770P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00286">
        <property type="entry name" value="PTI"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="2611"/>
            <end position="2638"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="846"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="934"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1605"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1796"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1981"/>
            <end position="2023"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2178"/>
            <end position="2211"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="11">
        <location>
            <begin position="2303"/>
            <end position="2540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9501142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2682" mass="293197" checksum="1E2ED013099AD0E9" modified="2023-02-22" version="1">MGCIRIMRMCLSPIDCPENHICIDGRCKSLCLADKDCAIGEKCFSGHCVLLCRHDNECLTTHEICNANRCQTGCRNNNQCAGHLVCTRNQCIDPCEGSAACGPNAICSVVNHRISCSCPINFVGRPSANVGCMRESISCQSNTDCHDAGLICTNNQCRQVCSANKDCAVDERCVSGRCHIQCTKDRECPTSEICLHNFCNVGCRSDADCASTETCMNNFCMDICASPTACGTNAICSVHNHEKICSCKEDTIGNPFVECVRQFVSCDQQTGGGCGIGQICESSYCFAQCNRDQDCYNNERCLNGICSTICTNHDACPRGFVCEFGQQQCTPGCRQDSECSTTDICINRKCINACHNPTSCGLGAQCIAVNHLAQCSCPAQQTGNPKIECKHIDCLIDIDCNDGEICQNYKCQPGCRSDSGCSSSESCISLQCVDPCMFAEVCGENAICQTIDHQPYCSCPSSNYDGNPTVRCMLKQQEELSCRSSNDCPMDSSCIHQRCIRNNECSKDKDCSIGNICIQGKCFAGCRRDDDCPLDMACQSQQCHNPCNTRGACGNNAICQPFNHHAKCFCSADHIGHPETECLPLPLCRKNDECPIGYLCQSNKCVQSIGCVSDNECRMTEICLNNRCTEGCRSNSDCSFKMACINYLCQNPCSMKTCGPNAICISINHEAVCRCPEGFIGDGYQGCRIQQNDCHVDKDCGIGKICISNRCIIGCRNDDNCPFEKTCYNRKCIDPCSLEQICGVNSLCRPANHKAECFCQPNYIGDAKVHCVESKQKLELYECSDDVGCGPGKVCEHHYCVDIIKQCLYDNNCHPGEICDQGKCISGCRRDSDCTFDRACYNSQCQNPCTIQTPCGSNAHCQPVLHRPQCRCSFGYDGNPYDYCKPMTKLPATRCTNDKQCPLGFICELNICTIGCRVDKSCPSELACIHKQCVDPCDLSDSCGQNTICTTVGHRPRCSCMAGYTGDPNRQCAVSTMLICVQDVDCSIGQICEKSKCIDACRTDDTCSYVTACINQRCQDPCSVYGACGHNDAICQAENHRAVCKCSSSSSIGGGDQNDHLFSACDRQQIILQPTDCLADDDCGFGYICNQGSCIEGCHHNDHCVPNEACINSECRNPCESPNACGLNADCTTNGHRAVCSCHSGFIGDGVSCYPFEEIKQCQSDRDCGHRLICGERSTCVIGCRDSSGCSDEESCINGICQNPCSLYGVCGRNAICQAMNRSAVCSCSVGFKGNPNVLCTDAPPQCFRDNECVVGQICENNQCISGCRQDNNCPEDRICVHGTCQNPCLLPKACGLNAVCQPFNHRARCECIENFRGNPFEHCEPIPDDYCEQDQACSLGKICENNRCIDGCRNDANCRFEESCINKQCQNPCDLFGACGQNAVCKPLNHDRVCTCVSDFTGNPRVSCERVLPPPECFSDFECPTEHICKNQRCTYGCRSTLNCPKDKTCVQEKCINPCKQSGACGRNAICLASSHVAVCSCPAGFIGEPNFECKEIPPECRTDDDCGTERICLKQKCIVGCRMHGNCPMDKACVNGLCQSPCNIGGMCGVNTICRAERHEAQCSCMPLYTGDPLKQCSKLSVECEQNKDCGNGYVCANNECKDINECLQEKMPCGPGASCTNLPGWFKCSCPMPLVGDPYGPFGCRSPQPVCLHDADCKPDQRCNPVTQECYDICSRPGVCGKGAICRGFDYKAECLCQNGYQGNPHVECTIRDSCVSDNDCPGNLKCQIDYCSCPKHLHQLGTFCIAQSFNCSLQSPCPLNQECVFINGGNTHQGTCICPRGFQLSLDGSCKDIDECQQNSNICGSGAICTNLIGSYKCSCPFGGDPYNEGCLTDNFREGCFVDSDCDADKACVETNCVNPCLKENSCGQNAICTVRNHRKECNCRPLFFGDPYSICRKPVECLSDNNCPGNLACMSDQKCGCPLGYERQLDYCIKSSIGCSSTKLCKGNQECILTKGNGFCVCMRGFRLSSNGECQDINECIEQTGLCAANADCHNLPGSYECRCYENHDGDPYREGCRSTPPPLKGCLQDSDCALNKKCNAHLGECYDPCVSREHRLGYKCGLNAICITENHNPECFCPPGGYEGDPFKSCHKKIICGIDYHCPGNLICLDSNTCGCPPNFLQENDYCYMKSLNCTTNNPCPTNEECVYTGSLNGFCVCPHGYEYHPSGECIDLNECLHVHCGSGAVCNNKPGGYECSCPPDTVGDAYVKGCFEIEGCISTADCASDRECDIGSKQCISPCYICGPHTECTAIDHRAICSCPPGRIGEPLDKLVGCYEEPDLPIESRTIPPPSEILVMCLADGVQVSVQLDRFDGLIYVKGHSQDPQCRRLVTSGEGDSIDFKVLFGHCGLIHIDGEASFVLVIQKHPKLITYRARAYHIKCVYNTGEKTVTLGFNVSMITTSGTIANTGPPPTCIMSICTLDGKEINSAEIGDDLILKVDVQPDFIYGGFARSCFAKTMEEEGEFQYEVTDENGCATDPSIFGNWEYDPHKKSLMARFNAFKFPSSNNLRFQCNIRVCFGSCPPVNCDGIDAFGRRRRRRRQIEVDEDDFILTDTFKEGALREEIMVQSNAILTFEKHGLQQSENIVENDSIHVEDIEHVCLPKLGLIISMIITTLLALVAVAVAISCWLMAYRRRPKGVGPLPHPPDFPNPLYTTPDPSLIEPLPDYYPSMQRHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU89</accession>
    <name>A0A922HU89_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DDX20</name>
        <name evidence="11" type="ORF">DERF_011077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU89"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="89"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="298"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9506339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="675" mass="77335" checksum="79A8EA0168FC4F84" modified="2023-02-22" version="1">MDLITDNKSSIAHNLEAKIWRSQDVDLSTYSEQTLNMIEIRTPSNNTNFVLKNSTKNTTFSLMKIHNSIVNDLKRCGFVWPSPIQSTCIPIARLGIDLIAQSKSGTGKTIVFVVCALEMVRQDLQNEIPCPKVLILAPTREIAVQIGDLINSITMKWKNFSCYKAIGGTKVSDDVEQLYHSQIVVGTPGRIVCLLEMNFLKPHSIRLFVLDECDKLMEENFKIQIDKIYNRLPINKQMIVTSATLSTEMTEYLSKYMRDPASIRMNADKPSLIGVAQYTLMIDGHCLDYMNFESKINPLLELLNTIRFNQCFVFLNYQTRVKYLYERLNNEGLSVIHITGDMSQKERLQTIEMFRSQRFKIFISTDLTSRGIDIESVNLVINVDLPINCETYLHRIGRAGRYGSSGLAITIVGRDSNEYGKFATILSQYNLETKRLHLPLSIDLWDNFRRDNVHSSNGLHCSSTTTLKVSPLFKQLQCTYEKLLKEPELIVHCEFKSSNNHIEKKSRKPLSQILEQLNIQKEKHLLSKEINSTTINKMNNPKSIGSDKSESTMIKSSSRTSLSNKHDQTTPESFANQNISNDENISIEEKNVNHLNRKCSTSSDDDKHSFKITSSADEQQHGQQQELRKIFHQTFLNPTTIINPLNSTNHYYENQSHHYQMNYICHYLLNGGRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HU99</accession>
    <name>A0A922HU99_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_011092</name>
        <name evidence="6" type="ORF">HUG17_5878</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HU99"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="13"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7643516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9506354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="300" mass="34559" checksum="38C138FB508B569F" modified="2023-02-22" version="1">MANNEQCKNHDNEDWFVETGVLNSDQCRLTIKIGRKLIEKQSKYQNILAFENEKFGRCLVLDDAIQCTELDECSYQEMISFLPLNIHPNPERVLIIGGGDGGVAREVAKHPLVKHVVQCEIDSEVVEISKKYLPFMGVGFENEKLKLFFQDGYEYVRNHKNEFDVIITDSSDPKGPATTLYQSEYYQALYECLRHDGIICCQAESYWFDLEFIKNLFHKVQQIFPSLAYASTAVASYPSGQIGFLIASKSKTVDFKHAKHQEKFQKIAEKLRYYSPEMHSSAFILPMFVQRQLDQVLNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HW89</accession>
    <name>A0A922HW89_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Electron transfer flavoprotein subunit beta</fullName>
            <shortName evidence="8">Beta-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_009210</name>
        <name evidence="10" type="ORF">HUG17_7163</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.</text>
    </comment>
    <comment type="function">
        <text evidence="8">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer composed of ETFA and ETFB. Identified in a complex that contains ETFA, ETFB and ETFRF1. Interacts with ACADM.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HW89"/>
    <dbReference type="OrthoDB" id="276685at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7636957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9510701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="255" mass="28042" checksum="92DFFC245675FEBB" modified="2023-02-22" version="1">MSLKILVGCKRVIDYAVKIRIRPDNKGVVTQGVKHSLNPFDEIAVEEAVRMKEKKMAKEILAVSIGPQASQDTLRTALAMGCDKALHVNVDEKSAETLLPVQVSKILAKIAEQEKVEMVILGKQAIDDDCNATAQMTAAHLNWPQATNASKIESKDDKTVLVTREIDGGLEEIEYKLPIVISADLRLNEPRYATLPNIMKAKKKPIDKKTPSDLGVDITPKMEILSVQEPAKREAGTKVADVDELLTKLKEAGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWV9</accession>
    <name>A0A922HWV9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 4V2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CYP4V2_5</name>
        <name evidence="12" type="ORF">DERF_010285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWV9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20628">
        <property type="entry name" value="CYP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9511860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="582" mass="67806" checksum="0614933D0FA8A6EE" modified="2023-02-22" version="1">MAIFIGNLNCLLNQYSTTIIESQSWEKLLSITTTSFIVSSSSLIKYMILISLFAFIIISIVRRQYQLVSIVNKIPGPPVNPWVPWLGHAYIVLDLDRCHYQHGTYALIYQMVSSVNKIYQQEGICRMWIGLKPLVLLYRPDDVEVILNSNTLTQKSAEYRFLNSWLGEGLVTSGRQKWRSRRKILTPAFHFRIIEDFLPIINEQSNILVAKLNRLTTNANNDTIEMDVVPIITLCMLDIICETAMGVKLNLQANSNHEYVEALYNISRIFLIRLMRPWLWPNITFNISSYGRLFNRSVEQTKNFTMKVIKERRNEWMKFLSNHNHNDDEHESMVDDFDMIKTSKFFKNSNRLAFLDLLLQHHLVTKKLTLEDLREEVDTFMFAGHDTTSHAISWTLYMLGIHQDIQQKVRDEIDMVFDCSESNIDLSIDEIKQLKYLDCVIKEVQRIYPTAPFIGRDLSEDTKINGYIIPKGTTVGIFTYVLHRDPEIYPEPEKFLPERFLPENCSGRHPFSFIPFSAGPRNCIGQKFAMNEVKIVIAKIIRHFYLRSIDPRDKLVIVGEMILRSINGLKISFIQRKLEQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXS6</accession>
    <name>A0A922HXS6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXS6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="497" mass="58806" checksum="D853D675E6C3E690" modified="2023-02-22" version="1">MDPTNIITNFNSLSISKSSQQRIVGQKFVAENVVKLFHEERLPSHHCFSRSNNHNENDNKHNETNELSLWPCLRHFTWSSLLQQQFGKFLPVDKGYSMFTIDQQENRLQLFSNGSNQGIFIGSIANKIIYSYSDSSNYLYILDEKHRLYFYPVTENSQNYHLKVLIEDIVKFRSNGKQCLALDSDGDLLVWWMIFHHDQSEHFDNIEFRPWKFQQIKEIFGEKFIILDFDCGQSNAVILACSSDYGAQAVHIWRQSFKNENDDYLETIHISYKRNFLEYYCRQPLIITKMPKINNCYNIPSTDIYIFISNNSWYIYNTQTGQQIKTSLRSLPDLYSFYGHYPSSPPSFCHINQQNCLQDPQQISILETFNNPFCYDFKIQIPMMITNQQTIIRTIYLCKAILQQWKPYFNHLFQQNPTLNETSELLLTIGYIEHYYYYKSMYTILLPTSIIHCEQIRQGIQKLEKQHEKPFIPISNTTNMSEDFDLNSIDLSDLIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZD6</accession>
    <name>A0A922HZD6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DC-STAMP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DCST2</name>
        <name evidence="9" type="ORF">DERF_008152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZD6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
        <property type="entry name" value="FYVE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="8">
        <location>
            <begin position="409"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type zinc finger" evidence="7">
        <location>
            <begin position="633"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9517479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="750" mass="88394" checksum="8B62020FCDE52AFB" modified="2023-02-22" version="1">MGAVFSSIFRVPMRIFRRLSIMYDLRNLKIIKMAKAKERLRQQYEKQQEQEEEENQMNDVYPDFVMEKPQKIVKSTKPDGNRMETFVNFLRQIFNVNQIRFLFVLMKSDTKENDISRRFLLFWMGISYTLLYFYIQVYVFEKFQTLTLLLVTVMAITTIILPQFSRWAQSFSLILMPRSVMIVLRGAILSVIAFQIHTVTRFNIERNYKILVTSIQCNVRKTERFASQSKSFGFGDTRGQKSFRFNFVNPFKPFVESVKSYALSISEFFQRTQAYLDKVNAVGNWIADKFTWLPSIDFGITGFLVDNIAKPLGNQVNQITDNIGKQILSWFEIKFHSNYHFYWKSSQPNQTIGSVIADSLNEVVERHSYIQYVMSFVEQLVHFYVFTVFILIFFPPLLYIYKFRRRPSFDNFYITDKLIAYDEEMVASGGTGVGLESIFPLRFVELFMYVRRTDPILTIQELQSALMSFIVDFLLLSYVLTFMLVDFIMVHVVVQFAKIYEFVYELALPEQFPKFLQILNTSSDASSPMKNLIDADTFVQDYQVFRQDIRQCLPIVSDIDWAPYRKCLTYFGLLMLWKTIRPYINRTRSVVCTNLYPKLAQSRVVYLYNHIWFQRMIMDVTMAVMSQDYTKAIRIVWQFVKQNYNIRKLERQRLKREKQKQGAAGLVDTLLGAPNMSPLNNCAICNKSFEQNELIQCPGNNCQVLLCWQCYKTATTEPNYRCKQCDTAYEQFLEDVSEVIDSSMNDELDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZG1</accession>
    <name>A0A922HZG1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZG1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="72" mass="8239" checksum="835F96706C2840FA" modified="2023-02-22" version="1">MLPITIGHSSKFLSINQPTDQRKLPDFGRFCIHQTSPQVFFSFFIKTTSPSTVIDSQQNKLPPQYIQLIQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZY2</accession>
    <name>A0A922HZY2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_009821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZY2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="138"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="234"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="430" mass="49560" checksum="A9C90623F50D0B6B" modified="2023-02-22" version="1">MSIVECNVWPKKIEIVNSNGEILNDSIIGPYDQGTDLTLICLADNDSFNHTSVIWYDENNTEIDSTFYTESNGLWIRNELILKNLTYKHLNAIYICRGRNGHYDIRKHQKYIPTYIQLDVNLRPSQIRIVLTRNSMYPTSKMYDNDSLILIADHPVEFECIATGFHPSIEIRWLLRSKNSQLIDIDLHINAPIIQFLPRIEYDGNLLICSAMNLKMENNSESIAIQPIRVYYKPRLTIIPIGDDRVEEGSDLRLQCRIEANPDVFSEGIIWIQDGQVVWKTLSNDNDYNHNNGIVKATKIFRKLTRAQNGSIYQCMAANEIGQNISEPFVLSIVENQSFIKFVDNIYKNKLFRGTSSSWHILHKNNSNSHWIRLDNNHIMAVSLALSILTLIIIINIIFVIFSSRYCCHSKQIDTINENNALTVVYESSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I003</accession>
    <name>A0A922I003_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I003"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9515993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="88" mass="10155" checksum="AA91D70DC66EB7F3" modified="2023-02-22" version="1">MIDCRQTFKMMLNIGQKLSNKFTVNVIHTISSIYVDSFSCNNIIRMKMDSQIKKSKISCNTIVIYDNGRNRNNEILLSLLLLLLDNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I068</accession>
    <name>A0A922I068_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydroxysteroid dehydrogenase-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HSDL2_2</name>
        <name evidence="11" type="ORF">DERF_008558</name>
        <name evidence="10" type="ORF">HUG17_2652</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I068"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09762">
        <property type="entry name" value="HSDL2_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000301">
        <property type="entry name" value="Hydroxysteroid dehydrogenase like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051935">
        <property type="entry name" value="HSDL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006133">
        <property type="entry name" value="PRK08278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42808:SF3">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="9">
        <location>
            <begin position="324"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7638619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9517944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="417" mass="45547" checksum="E3E5733D9A277C48" modified="2023-02-22" version="1">MLKNTGAFAAKTVFVTGGSRGIGKAIALKMAKDGCNVIIAAKTTDPHPKLEGTIFTAAKEIENNGGNCLPVQCDLRDEENVIRAINQAVDKFGKIDVLVNNASAISLTGTEETTMKKYDLMNQINARGTFMASKYCIPHLKQSSNPHILNLSPPLEMKSRWFAPHVAYSMAKFGMSLCVLGMAEEFKDSGIAVNALWPRTAIWTAAMGMLSGGQQEIAKMCRKIDIMADAAYAITSRDSKSCSGNFFIDEEVLRDEGITDFDPYAIEPGTQLMGDFFIPERLMEGLAGLAGTSEEGKTSMTDNSSSSSDRIMEVLNQARSKMTDKIKDEINAVLVFVVSGRTYLFDSHSTRPLKIEPLQQAPDECDVQMITDEETFIQMAMGKIKPTNAFMSGKLKIKGNLQLAIKAEKIFKAVNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0E9</accession>
    <name>A0A922I0E9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0E9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="172" mass="20229" checksum="A866C6A389730F43" modified="2023-02-22" version="1">MVAKKIDISKELSQPTIRQFFFDDNNKTSPSSSSSQMNHQSIRYFSLSNPKKMLEFLILREMCPLFGDVTNIGRVLNRLIETIYINRSLNAAERRTLDECIENMERINRRRIQISLAIQQFQDLNPRGGQVCNIYRLFVMNIDRVERILQQINELLSQNVQQAQEDSEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0H0</accession>
    <name>A0A922I0H0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_007929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0H0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF12">
        <property type="entry name" value="SUGAR PHOSPHATE EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9517249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="242" mass="26158" checksum="972939E2E8FFDD84" modified="2023-02-22" version="1">MKKLSTPSPPLPPPPTTTTMMMNGQQNDDHHLKVNDKEKAISLWKALLIPGVIEFSICLAFAKSVSYIFLNWLPKFLEENDHLSSSSSAYESIMFDIGGMVGSIIAGLLADKTNSSGLICIGFLILAIPSLFIFEKFSSISQAMNFTLQFIAGFFINGPYALITTAVSTNLACKVPSKSAMATVSAIIDGTGSIGAAIGPAITGPMADRFGWNSIFYLSMIADFIAILCLIRVGYQEIRHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0P2</accession>
    <name>A0A922I0P2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/arginine repetitive matrix protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SRRM2_2</name>
        <name evidence="3" type="ORF">DERF_007247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0P2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029360">
        <property type="entry name" value="SRRM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15230">
        <property type="entry name" value="SRRM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/arginine repetitive matrix protein C-terminal" evidence="2">
        <location>
            <begin position="587"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="651"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9516512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="683" mass="77397" checksum="26C06AE7D01C57EC" modified="2023-02-22" version="1">MENSNTLIAGENKPQAKYNKNVSIIPMIRPIVGSATNPIDDRQQQSSISSQQSYSCNHDSSSQSICCPHQILFNAFSNHIIPFPYCIYNNNNNNSSNSVINNKNSKQLDRSNQSKPLSSAAKRRIRRKRNQMKRFEAILTATAAATAVSILSHQKHYQQPLHIHHNLTNNQRKISKNNGYPLNNNNDDNKNISLSVSNKHLNNTNNNNTINHNDKQYSNNDPFYNCKNASSFKIKSCLSVKETHQLAELNRDRNDKLKAALGISEDFVAGSSMDIIRKAKEQQAAKEEMLKANKDFIQETIRQQSESKGNKNSRNDETDAIKTSKKKIKKESSSDDDDSSDSSSSSSSSSGSESNSSSESESSSESDSESEKSSSDSSNSDSNSSEDESSYDSHRKKSQPSKHRHGSLKHSTFHHRHNRRHSPSQRSRSKSPAVFENKRRSYDNHHRIHRKTNRKDSQSPRRDSPSLSNGRRDDNVKKMSPEHDHHRSSNSRIKSVVSSSHHRVGRHRHNDEREKSPSSRYHRSKYSSRSKSRSPVHSRRTHHSKLSRSRSPSSSSSYSDDEIDDKNYRHQNKNNRKRQRSRSVSISNSSSSDDYAHNSGDSPSLGRRNKKMKKYSRSRSPSIPRRKGSPSFLEKRRITSARKRPVPYRRNGSSASSSGTTPSNNKASIGNVFDLSPPLRYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I0Y9</accession>
    <name>A0A922I0Y9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I0Y9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9518121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="87" mass="9772" checksum="38B3F4123A8EBA81" modified="2023-02-22" version="1">MFSRNIEPQSDAALKLECGSINGEARFPWFRCLLIIFISPTKWLVDWPFPPPVATAVIIEVGELLLLGINNGEELFDDVDKSDLPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I184</accession>
    <name>A0A922I184_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_008847</name>
        <name evidence="10" type="ORF">HUG17_4797</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I184"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051440">
        <property type="entry name" value="Goosecoid-like_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46643:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46643">
        <property type="entry name" value="HOMEOBOX PROTEIN GOOSECOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="186"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="188"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7641752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9518256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="261" mass="29886" checksum="BD9587F84B8D6EC9" modified="2023-02-22" version="1">MTTSSNTSDSRTNSSQTTTATEPRTEMKRSKSFTIDNILHDVDKQPQLKNFHTSSSSSSYPIWLMANWMAISSNTNPYASLRIPTSSSCPTGNTFELTNQRIIFDVLSHNGGGIVASKLGQNQSCTSDDEHKGNESYASNILKDQSYLSDCSNDHQPANHHAHTSESLKSLFPSNTYYHCRNGFYKRKRRHRTIFTEEQLELLEAAFHKTHYPDVLIREQLAARIDLREERIEVWFKNRRAKWRKQQQRLGGPTIDIITND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1E3</accession>
    <name>A0A922I1E3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Corticotropin-releasing factor receptor 2, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CRHR2</name>
        <name evidence="3" type="ORF">DERF_007925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1E3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031139">
        <property type="entry name" value="RPGRIP1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240">
        <property type="entry name" value="RETINITIS PIGMENTOSA GTPASE REGULATOR-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14240:SF5">
        <property type="entry name" value="RPGRIP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="481"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="599" mass="70286" checksum="1BA4D8F74C8747FB" modified="2023-02-22" version="1">MTPFVIVIVNFEWLTPEYMALNSNNQSIDLIEKKENRMLRHKSTPCLLELAKSSTTTTMTTTAAASAAAMNQINYHRHRGNDLQDRYHYLQEQHQQLKRETNDARDQIRKLNTRLSRLLMEKKRLLKNVKSEHEIMIEEQMFELEQQLRQKEQQNERLRERLKLMYHTTIVGDHHQRLKSSPLPAKSIRATSAYSNVRSRTDSGLGFYFRPLNLNQSSSSASKMAQSSRRSRSQTDRSVKFQEPPVEKISENFSTNDEEISLKTAIILIQEAKAEIIRLESIIEQQQRIIDSFNQNDSIITNDPESMMIMTTTTTTTTTTQTATTAATSSPNSDGNDNQTIDSLWLKYQKIVNNKEHFQRISLECQQLFERLYSALKQERQKCDQYRVQLRQQQAEQEMSMAESSTIYQQQSSAIISMEKDKIIETLRKENLILQNSLKQCMDQCISIPNNDDDMKSVNVNQQQMSISINEQIQQIWYDKRNRYEKQIIELNEKIDELNNDLYRQQRNNESLRIRYENLEQLNENDQLKIVHLEEKISRLTEILFRDLDNKIIDDDDGRQNKLNHHHDTTFMNGSTKTRDDYDDDDDVDGVDIIHDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1J9</accession>
    <name>A0A922I1J9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1J9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="534" mass="61346" checksum="DAE20EE072093A63" modified="2023-02-22" version="1">MAKKKSAKKKKQNRNNNNNSNNKNKLNNNNSKNITPSQSSSSSILQLQTNNNDHHDTMNEYDIGDDIYSSPISPSLPPIPTPPPPPPPPPPPSSSSSSSSNQKHFINGTIINDNKFCLNHHRNYEQNVNGINFNVDGDHLQNYNDNNNHVFNTPDSEEDTVSFEIDDNVNQFNGGGCCDGDDVGGPNNNNCNDNDNVINLDCDDEQLERQILSKTANGKYKFYSESQSLIPEHNHQTSKTSSHHSIFNDYSDDCNDFYTIYENHSLYPEQPPPTTTTTTTTKSKQPQQQQTSKKILYHPIQLQNSMFFPVLDTNVDDDDDDDDEDDDDDDNGTGDGNGDTDLKHPFTSDMYDMFFLEHGNCMFQYLRQQEQQQQQQQQHISYEKKQNKKSPINLPILPQAFPRIKFDHHYQQRQQQHFDSYYDYYIPRSESEDNILYRTSPKLRFEDMPSFENHQTHLQQILPPPPPPPPPPPPRKLFELQNQQQQQQQHTMNLPLPATTTTTTLPNSNKKKNKKKKNKNKNKIQQQPATTNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1L4</accession>
    <name>A0A922I1L4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_008773</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1L4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="79"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9518178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="401" mass="45897" checksum="E17987D5FA5482A8" modified="2023-02-22" version="1">MKTSSSSTVTATITTTDSTAITAMIIMATSQLQQQQQQQQQPYNEQQLYDPYPDLTQISAIRFIFIFFYALIMISAALGNLLIIYIVISNRKMRTIVNYYIVNLACCDILISVFVLPTKMLELLAPAEWLALNNTWCTVMSFLQSVMVFASLLTLVATCFERYFAIVHPLKSRMQQGKRRTYRILLAVWLLSSFASLPNLLHGSMAVINVLKSEYGTIARLTCMPTFDDEFRMVYFTILFICLYLIPLALIAFTCFCIARALLRTSILHRQGSLLRQEVNRRKVGKMILVVVVSFTIAWTPYFLISVITQYQKENYFDKHDYYFTMLSINLFGFLHSSINPVIYLTMSARFQKGFMRLLRLVVCCQKPKENVGHTSIPDPGTSSRYSPNGNINNMPKIILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2C9</accession>
    <name>A0A922I2C9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_008437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2C9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278:SF19">
        <property type="entry name" value="OBSCURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23278">
        <property type="entry name" value="SIDESTEP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="835"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="149"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="271"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="437"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="534"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="954"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9517807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1094" mass="122280" checksum="645B3BFBACA27578" modified="2023-02-22" version="1">MTSLSTTSASASSSSSSSSSSSMENVKVMTSFTKDSDGQLQSTEIVELVKINQQFKMALPKDMGTVVVRIREDTRLPSDADMPMRFICKLPCKEQLQSQSQQQLDGAILTAINDSLSSSSLLSGSGGGSSSGGGGGVSTTTSIIYTAVDGGKVALPCNIIPPTIDDHVVLILWYKDDEFEPIYTIDARKDPLEKARIIASPNLIDRVYFNQHNQPAFLQIDPVQTKDAGEYRCRVDFKKARTVNIVIQLKVIVPPEEPIISYKYSQSTSHPLKGLIGPFNEGDRLVLVCTSFGGKPRPTLTWWKDYSIIDDSFEYKSKDVTTNELVIESLARHHLLSIFTCQSSNNNITIASSASITIDLNLKPLEIKIHQISSSLLANNDAKFECKSFGSKPKARLYWMFDNVRYDTTLQGDMQTISIISLPLKRENNGHILSYVPELTLQLGTTTISLNTIQEGNDIYFDCILDANPMPTTPLIWRFNDEILEPRQGIIQSNYSLVLQNVRRHMSGDYKCEATNQHGTRTSNSIILNIRFAPYCKFKSTLAYGLSLFESNALVCEVDSNPMPSSFQWKFEKQIELTTVHSYNYSSLLYYMPNSTHHYGTIECIAKNDVGMQQIPCKYHIIDSGPPNFPFYCQLYNQSIDKITIKCTSENDYQIISNDNVDDDGDGDNDDDDDEQQPKHKQYLSSSEMTIDNQYNHQQQQQQQQQSAKIGQTIFVHPTTHYIAEIYDKHGQLLQNLTLNPPMPFSNISTLINQTRKTSSTSMTMFNFQIDHLIESSNYKIKIYALNTKGTSDHRWINAQTLRKAEKYIYNNSKNFTTDTTGLLFTNYAMNHIKIIMVSVCGSLTIMLIVIVIAISYMSKFCQRIRNNNNNKKKNYGRKLKNGDNFKIHGDKNDDNDNNDDDDEIGLNVMNNHQRNDVCSNVDMNITNGTMINTTTTTLNVGCGGGGAGGIVNDNADNNSGHHHHHHNNNNHHGGGGGGGYGTLDNLAIPTVYTETNVICNEYYSNLLAGFSAKDNKSNMELLSLDLYSMNPAIAHGGHHTGHHHHNHHHHLNNKGPPDLIPTFYYNPSTSTNSDDCTTIADTDRTDLMSSINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2U0</accession>
    <name>A0A922I2U0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exosome complex component 10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">EXOSC10</name>
        <name evidence="13" type="ORF">DERF_008252</name>
        <name evidence="12" type="ORF">HUG17_2425</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7638392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2U0"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="11">
        <location>
            <begin position="497"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="613"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7638392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9517592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="757" mass="88478" checksum="C959C0AEA9FA5EE6" modified="2023-02-22" version="1">MTTSSSVSDTTATDSFTTADFNDKIKETILLAREIMQNSNAKKNEKIQDLIKIQCCNTLKILTKLNQNDLNPNSRDCNFTRTKFDDQQKIAKLIEIDDALIDKTIHYFECAENLKEKKNSVSNLIQVQMNVNQKQNNSRIFIKDFSKNNNGPLLGVNIKRKHSDNNNTGHLESKRNFMFMAASNVKRPQIAYKIKVDNAYSTPFIPKLRRKPNAIVSLEESMKPLPQNEPPANLLSGYNYPKHSYQHPYQYEIENFTISSSFFTKHDSNQFKPPPSIQEKPYKFINKRDELCELVRELKNFKEIAIDLEHHSFRSYQGLTCLLQISTDQTDYIIDVFPLWQDMQLLNEIFTLPSILKVFHSSTYDIIWLQRDLGIYVVNMFDTWVAAKTLGYQHLSLSSLVEQFCQFQMDKRFQLADWRMRPIPDEMLQYARCDTHFLLYIYRKLKQELLNTSDQTGNLLRVVMERSQQMCLKRYEKKLPEINDHVHLVWKNNLRFNQRQMAALKSLYAWRDVIARQEDESTGYVLPNNLLLKICEILPREQQGILACCNPIPPLVRQYINEIHMIIFDARSKVLIDQHSSTTVISQEKTDITIDLTNDLLIDHHSSNPNKMAIDHPDHHDHLSHEHDHVLDDQQPLLRWSKEFGKFISHKQFADNDDPMNGSHTSTSSSSNEIQSITKDMNQHSLIDMFDNDSIDCSKKYQSSTNDKKNQKEKRLPKSKIDVEMEKLFDGYITFYQRYLIKLKQKDEQSQSSSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I375</accession>
    <name>A0A922I375_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_008892</name>
        <name evidence="13" type="ORF">HUG17_4758</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
            <tissue evidence="13">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I375"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH7641713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9518302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="118" mass="12862" checksum="7B976AD83636B7DC" modified="2023-02-22" version="1">MPTLIIRTNVAGSKVPANFTKDMVKIVAQTLGKPESYVVVMVHSDANLNWGGVEEPAAVCTLSSIGKISRDENKKSSAVIQKAIESKLGISTSRQYLVFEDLKKENVGYQSTTFDDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3P8</accession>
    <name>A0A922I3P8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase A catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PKAC1</name>
        <name evidence="8" type="ORF">DERF_008660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3P8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14209">
        <property type="entry name" value="STKc_PKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044109">
        <property type="entry name" value="STKc_PKA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="7">
        <location>
            <begin position="244"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9518057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="296" mass="34311" checksum="753B58BEDB5998E9" modified="2023-02-22" version="1">MLVQRKSGPDAGKHFAMKILDKQKVVRLKQVEHTLNEKKILQAVDFPFLVHLDASFKDNSYLYMVLEYVPGGEMFSHLRKTGRFSEQMARFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYIKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFYADQPIQIYEKIVSGKVRFPSHFSVELKELLRNLLQVDLTKRYGNLKNGVNDIKNHRWFSSTEWIAIYQKKVEAPFLPKCKGPGDTSNFDDYEEEALRISSTEKCAKEFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4I6</accession>
    <name>A0A922I4I6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_004225</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4I6"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="28"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9520521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="376" mass="42775" checksum="B6E3809994825CC2" modified="2023-02-22" version="1">MTGYSRLAQEPTETDKVSSETLCSKYIRIATVVAFYWFVSITMVFLNKQALNQVNAPFFITWFQCLVTGVMLFTFRVLDDWRSSKWMNNKCQESLISDNGVISIMSRFLVIPCYQIRFSVVKRILPLSVVFVAMISFNNLSLQFVGIAFYFVVRSLTPVFNVLFSYIILHKKTSVRSILCCMGIIFGFAMGVDQEQALGTLSAIGVLCGVLASMFVSLNSIFVASMLKVVDQNVALLSYYNSIIAVVLFIPFIMMNNEWHMIIAHLGDHHFWLIMATTGIFGLFISIVTNLQIQYTSPLTHNISGTAKACSQTILATYVYEQHKTFNWWLSNVIVLASSTMYTFVRQQEMKHTFQQHQQPPVNETRTDPEKGQTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I4W6</accession>
    <name>A0A922I4W6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I4W6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9520701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="107" mass="12617" checksum="81209760D6CEA0FD" modified="2023-02-22" version="1">MKKSFSRPYRYHRVPVPVNVVDRNSIHTIITNNDSNSIINNNNNNNGQLIVIDEEDDDIVINYKHRNDDDDHDDNNDEDQHKNNNETITMLHSKSASQYVFYCSYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6F9</accession>
    <name>A0A922I6F9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LHFPL tetraspan subfamily member 6 protein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_005747</name>
        <name evidence="6" type="ORF">HUG17_3327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6F9"/>
    <dbReference type="OrthoDB" id="5873721at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF16">
        <property type="entry name" value="LHFPL TETRASPAN SUBFAMILY MEMBER 6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7639294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9522148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27624" checksum="29AD86E334B44149" modified="2023-02-22" version="1">MLIQDDTNEQKIIESSSYKHPDDIESDHHYHRTTHLLCSFVWWTALSLIASLLIAAGFWLPYWIQGFYDDDNGSQITTITFSPFRRCNFPVINNDGNVNIMFKCIRYEHFDDIPSLSWKLTTLLVGLGVLFSILVALILLFACCMPNALTSSNTCLLVIVQLLIILVIITGCIIYPLGWNDQQQQQQQIQHICGAYNLEKPFELEKCQPSLSIYLLASGLILLIICLMFGICTSRQYRKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6V6</accession>
    <name>A0A922I6V6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RUN and TBC1 domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SGSM3</name>
        <name evidence="9" type="ORF">DERF_004223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small G protein signaling modulator family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6V6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF13">
        <property type="entry name" value="RUN AND TBC1 DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="7">
        <location>
            <begin position="117"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="451"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="RUN" evidence="8">
        <location>
            <begin position="526"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9520518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="716" mass="82451" checksum="015E274B860C5A76" modified="2023-02-22" version="1">MNNSKQTSINDPFSHLHPSLLTPDDITCLVQTSNVDGDHSYDRYGFKIVRSTISKDDRSDSTELDEAQWYTETKSQWISFLESEYRRMAPSSCLDLSQFDSTEIERLPRLNELICLSISDELRPFFWIRFSRALHLKIASKWSFPQLIDLSASEPSLSVHQAAQVLPNNACFTLNSVSNRLRRILQIVHWYQKTDLAHNDNNGDQQFNLSLIGAYLLLICSEEDAFWLLLQITLSVNLDDCIELIGQIMTKCCPIVNTLLRKHEIEFKLVASIWFSSLLAGFVTNAFLLYALWDLYFYEGPVFLIQITIGLLITETRSLESCQDSKEFFNTLSDLPLNSLRSLDKIVYVWKSGKNIVANINLPGKLYNYENQSNADQLLGSIVANQDIKQDELKMKNIKQTALIMKLHEAIVAIGHHFQAYEPDAHYRLDPDYDNVDKVDIKQDMMNRLRPYQHRAKALIDFSSDDPDELAFAKNDIITIINEKDEHCWIGQLNDRFGWFPAKFVELLDERDQDYSIAGDDRVVPFINDLVRGKLSSALKAILAYDLRKSFFLTIHPWTIIEQISTMTTNAGFKSVFSRLVLTKTFRLDEYSRVLSPNDLLYRSIALINRTHNDCPMDIKLRSLICLGLNQYVLHDWFELICVSQPSIIFKSYGSNSFLTSPAWKLIKAELKLLVQFSFHLNIDAEIPNGHEPKSPVTKEGVCDMLVKYHLFSWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I701</accession>
    <name>A0A922I701_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SERine Proteinase INhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SERPINB10</name>
        <name evidence="8" type="ORF">DERF_006183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the serpin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I701"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF211">
        <property type="entry name" value="GH10112P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036712375" evidence="6">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="7">
        <location>
            <begin position="46"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9522617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="407" mass="46697" checksum="AC4ED1725AA8F64A" modified="2023-02-22" version="1">MAICLIKIYLICIMAINVLPKQISSYSNRPIIIPRKFTLVANYFGFNLLNQLNNEQSDDEIRKNILIAPLSLTATLTMLHLATNDGSPANQQLESILAFSMANISPDRHRERESLRKILLKTNDLKNTRALVANQTLKINLDYAQMIQDYFKAEIIINQNPTDFIVNGSTLIEHIPESNEAVMLLDAAFFHGIWLHRFDITNTRPSTFYGANFISYENVPFMRLKAAVAVVPLDEIDAAMIELPFKDQRYALYMILPSRINDDLSLIRRAINPWYIETSIRRMDVYGKIMIELPTFGIEAEYDLRGTLERMGIRDIFHQKMANLSSIMTDQENIFVTDIKHKVRMEFGENGIGPVDSMYTKKRKSKQKSKLNINSKSAALAFDHPFLYFLRHTRTGTILLIGEIHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I756</accession>
    <name>A0A922I756_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COG5</name>
        <name evidence="7" type="ORF">DERF_005569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I756"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9521961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="785" mass="91761" checksum="D0FA7D9A57D8E544" modified="2023-02-22" version="1">MLTNNNKKQSMDPIYSEFLPENFDQQNAIASVNNLPFSEQISKIAAGIEQLKNNINQLTTKNCETFFRRASKLDELYNDLRFIGIKSQNLMKTMELMIMKFESPYQQLNHEIILLSRLQKTCDLLRKMLRIMYLMERIDESNMNNDMTKNESGIFLKEIIKLSQYVNEIDGIIQSDEENLLHKLNCISKDLEKFQQIKSKIIIEADSLLRNGLESLDNNNIGAALQIYHNLRSLDSIVNDLIVEKCRLIEQSLSKLFDDMNMNEMKLTIPSSTRQNNLMKTSIRSNCKCNLENLYIHFHQISTMIKILKKRRDNQTQTLLIEFIDNRDELIRKFWNEIIRIFSASFNKLFHWSPAIKRLIESDYSKILSFFLDYSERIIVDEPEIENEITLRSTIGQFENAYLSNSLSSLFESVNRIFTNVGVIKNQKIDSIPSEKDVDLVIKDISNEIVASNFDSMLLESVCRNIVKTINLFVFKCEQLVSNDGDATQVIGKFTINQRHNSLIIYSLNYFHKQLKNLIINNDKNQSILKKHLIETSSSLKSIDNLILNTFEPFIKSIQDAIEDIILTIHNEKYDINSKIMPSNCSLYMKELQRFIARISRDYFQQYPNDAEIIKERIHQMAAFVIDFFLLQNCLIRPVSAMGRQKIFNDFTQLEEAIIPICDRLGDVGRSFQILKAFKTLLLLSPEELCDAPIVGDPIPYYLVIYFFIANHTTDELKSPHKFKDWSISRYSQWFMAENRNDEERLSIIRNSLNEYIIQAKKSQKKQYFATYHLLSSLMKKTNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I940</accession>
    <name>A0A922I940_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I940"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9526547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9813" checksum="CD535BE3933BF258" modified="2023-02-22" version="1">MDKEEPPVWSLTLKYYCYGHFNMFIVIVGFIFNMITFRHMIEIFCSITNKHNQRLHNHHKFFIDDDDNNLDKVDDASLTASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9Z3</accession>
    <name>A0A922I9Z3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9Z3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037479543" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="11237" checksum="F6EA786C70A9E950" modified="2023-02-22" version="1">MLIWLFMLLLNIHELFEILAISSGITVIRDGILTYNNHHHHHHHHFNLFMSRTMNICFLHVVLKMLYFCFSFEIDNQIKTNQQNNRNLNNVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAC4</accession>
    <name>A0A922IAC4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAC4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7500" checksum="B52BC369A24F58A0" modified="2023-02-22" version="1">MNKSANVYCLLYNNNLDDDDPKFFRILLPFFFILFIGILTVTNFEYEFASMLKKNENNLHNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAC6</accession>
    <name>A0A922IAC6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Slit 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SLIT2_2</name>
        <name evidence="6" type="ORF">DERF_001846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAC6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="5">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9527854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="284" mass="31186" checksum="6BF93EC91D346EC4" modified="2023-02-22" version="1">MLGYIQYRKPDKVNGSPNVYFSKTSEIRHLTCLSSAPEGNTTTTTTTVSILNHHVIAIHSFSILVSTIKATIIFAKIQSFIFGGCRLSIPKQRQGQVYPVSNFDTRSQSISLGESSSRSSSSSSSSSSTSTINKNTVRFGFWNLNDNITVSRSINWIQLPIFSVWVSSVLSLLGLTSSSSSSSLVTGESFIHTNKNRRSTIMMTTITAMHFFTLALLCLFILLGAHYSDALFDIGQSPSFDSNSYGVQLSSCPLECDCQGLTVDCSHRGLSYVPRTFPLEVRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAU1</accession>
    <name>A0A922IAU1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heat shock protein 83</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HSP83_1</name>
        <name evidence="13" type="ORF">DERF_002522</name>
        <name evidence="12" type="ORF">HUG17_10489</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
            <tissue evidence="12">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000010">
        <property type="protein sequence ID" value="KAH7636519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAU1"/>
    <dbReference type="OrthoDB" id="5426351at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="11">
        <location>
            <begin position="31"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="219"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="124"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH7636519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9528592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="730" mass="84587" checksum="FF9D312EA7E6DAB1" modified="2023-02-22" version="1">MPEENQEIETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLIDPSKIANCKDFYIKIIPNKDERTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVADKVTVHSKHNDDEQWVWESSAGGSFTIRPDHDNGEQLARGTKIVLYMKEDQIEYCEERCIKDVVKKHSQFIGYPIKLVVNKEREKEISDDEDEEMKVDETEEKTTEENKDDDGDEPKIEDVTDDDKNDEKKKKKTKKIKEKYTDEEELNKTKPIWMRNPEEITQEEYAEFYKSLTNDWDDHLAVKHFSVEGQLEFRALLFVPKRAPFDLFENRKQKNNIKLYVRRVFIMENCEELIPEYLNFMKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCVELFEELAEDKETYKKFYEQFSKNLKLGIHEDHNNRKKLADLLRFYTSATGDDVCSLKDYVSRMKENQKHIYFITGESREIVSNSAFVERVRKRGYEVIYMVEPIDEYCVQQLKEYDGKQLVSVTKEGLELPEDDEEKKRFEEAKEKFENLCKIMKDILDKKVEKVLVSNRLVSSPCCIVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKNLEINPDHPVIETLRQKAESDKNDKSVKDLVILLYETSLLCSGFSLEDPQTHASRIYRMIKLGLGIDEDEMAIDSNEIDGTIANTIVPDADADANDKSRMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IB74</accession>
    <name>A0A922IB74_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000272</name>
        <name evidence="2" type="ORF">HUG17_8111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IB74"/>
    <dbReference type="OrthoDB" id="8017485at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7640642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="151" mass="17726" checksum="2636EC1468F161C3" modified="2023-02-22" version="1">MDIAALKLFEHVPTLTDNNWPIWKWKVELALKHMEMWPLVNDGDLSQPNDDIKIRSLIGLWVDDSLVPLIKDCKTSHQMWTTLTEHFENEVQPSTSTTKLLSNPEKNSESKSIEKQEPKIRLKCIFCERDGHNEKQCWRKKRLVHKLKPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBJ9</accession>
    <name>A0A922IBJ9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBJ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="91" mass="9983" checksum="5CABF188007AF3DB" modified="2023-02-22" version="1">MVLVNGHLMMAKKKVDKNENENENVNYTQVNRKKTITGVFPTCGDNSGKIGFFFTDGIGGNIVCIGNFNFGCNVDIVDIDCNVCCCCCFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBL2</accession>
    <name>A0A922IBL2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">R3H domain containing 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">R3h domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">R3HDM4</name>
        <name evidence="4" type="ORF">DERF_000477</name>
        <name evidence="3" type="ORF">HUG17_8280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBL2"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="2">
        <location>
            <begin position="76"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH7640811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9526379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="301" mass="33766" checksum="85CEE684A64BCB5B" modified="2023-02-22" version="1">MGVIRNNFNNFENSGAGAGAVGGGDDDWIYISSDGEESFVGQNDSISNQTAAGRSKTPKSKKSPTKPEPTFAALGAKGKSHKKFRRYANANLLNDLGNLINESELDDELSIDDFIPSSSSPSSFTLLMDSCTNQLFNLNDFINCTEDEQSMLLDRVIEFELTKLRNNKRHSSMTNDDKHLDLDDDDDDDVVKEEDSNLCFSRISPTIRKQLLKKHVPLGILASIEQKVINHFRHHPRSLYKTALQCSYQRFLLHACCQYLNLNCRSSTTNGKRLSCVNNGRLQFIQPSKLLSEHLDLSQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ICA2</accession>
    <name>A0A922ICA2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_000773</name>
        <name evidence="2" type="ORF">HUG17_8513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7641044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ICA2"/>
    <dbReference type="OrthoDB" id="6511040at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7641044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9526709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="125" mass="14582" checksum="EBCDCF50EDEE4A7A" modified="2023-02-22" version="1">MNKELMLIQFSKYMTIGTVSIIIGMIIALIGLWIYSEWLIYQQKKNKQLDIVRDKMDGIEMKRLLRQNSQEQSSHKQKCPDIQIVDLSLENDNPEKEKMISSNRSITQIDSNKRISLKSLDGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDX2</accession>
    <name>A0A922IDX2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDX2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8868" checksum="36D1B98479E4BF5C" modified="2023-02-22" version="1">MKINVFHDYSYILLINDDLDLDLAPFKKKEREEVPLLSTTMKSHIAPTGKNLCDKCGGSYATLAALISHKKSCKTSIIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IE06</accession>
    <name>A0A922IE06_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator super domain-containing protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MFSD6</name>
        <name evidence="9" type="ORF">DERF_003315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IE06"/>
    <dbReference type="OrthoDB" id="5989317at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17335">
        <property type="entry name" value="MFS_MFSD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="93"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="695"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="704"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9529430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="742" mass="83887" checksum="8ADBE4FFB6A1709C" modified="2023-02-22" version="1">MSSQFPRGQYEDPSTIMDSSLSGQWTSAQEQQASTSNPEQTQTILIDNSGGGATVTVAASRRQGERLPPFSFITNPTINQILIQINPDLFISKLFYFFFYSAFGSLFPLMAVYFKQLGMNPIQAGTLVGIRPFVEFIAAPFWSSIADRFHKSKVILLFSLGCWIVFTFAMAFIRPPASACVIFNETHHILYTPYSETPEEEVYDDASSLWPTTEENIPNSSVISNSINEFDTLVSYQNFRMKRDVSENIKHKLPPNHVVGKSPLTVEYTLNYNQEKHVTYLSPPFSTVVYKLEDVKEVFFLLLLLIVLLEFLSAPAITLADSATLDYLGEDTDKYGQQRMYGSFGWGITMLLVGMALDNSTKFKDHPCGPHSGERNYVTCFSIFAFLMSCTLLIATKFKFEESPEYSNEIQLNSYENEPGPKPWQNTAPAINIPKEFQDKKRKEEFIDRWKSAVFAQRTRTLPSWVAVLRSMNNSRKLAFLLVTWLMGFGVGLVFTFLFWHLQDLGGTPTLYGYASVINHISEIGAYFFSINLIQRFGHTKVLCFGLLCNTFRFIYISWLDNPWWVLPLELIQGVTHATVWAAACSYMTQNTELELRSSAQGVMQGIYQGLGRGSGSLLGGVIIHRFGSRITFFLYGLICAAFLGLFVHVNYYRKNQGYKFEEEITEDPMIMINDSSALAPHGVPTNPIARSVSRQNVDHPENHLQQSQPANNRMATNLNPSDNDNVASNSYETWDPNAAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IES5</accession>
    <name>A0A922IES5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IES5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="824"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="905"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1042"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9530191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1136" mass="122226" checksum="7D30C5525C191A10" modified="2023-02-22" version="1">MAKCDSLSDDLSAMHHHTQHHPYHYQHHHHLHHHQSYHEPQSKANTYGPNASLSSLSQLSQSIGSASTNQPGPALLPPPQPQPTELNIKEEPRDDSLRTSFATASSKQQPQRQQSDDKHFHFDNNNDNRAMMMPNDMHLHHHHQHTYPHHHSLNSIHHSNNGNNAHHLASHTFNTGSNVITKNNNGHHNRLWSNASAGSLISSSSSASSSPVHPVFGSNGGVGGGGGQCPPTPATPASLASYFTPSTMQSLPLPSSSSSSSSIYSSSQSQELLRHELDSRFLAASIAAAAAAVSTYDGSSSRQLQPPLPPPLTSFNNISGGGPLTPTPHHHLFAHNLKNSPSPSLMMIPPPPAPSTAASTTTTTTTTTLANASPYMSNANSPYPLNNNTTPNRPYEHDHNSSMSSTSSSTLTNYPMANCRKPVSTTMQQPQTVIIKPVASAPNVARSTMKFEQPSSSSSSSQLSLQERKGKIRGASMHVKIAWNIYQDRKYANLNNKGQHSSEERDIKKENTSFIPMMKSHRSSSSISKAKQQQQQHSNANIAPVITHVESTSQPIHSIPQKPAAAPPPPPPQPPSDPVLLSISNYSTTTVKALDPYNGLTTLTRSQSVTTITQQYPTRFPHPGLPSLSAPPNLPALYPPAPIPAPPPPPPQPSHAGSFDMWPRPSPPSPLTSSTSIYGRNQPPIISSNTNDYYSAALSAWAAFNRPHTDHLMSSSAPTLSRTNQSPPPSMDKHVSGQKRKNESSDSKNRPSSNKHQHHNGDIHHHHHHHHHRNETSSGKKSKQTKQQQQQQQQQQHSMENGNLLLPASNYLLGATSRHMDHCSPISPLSSSSSSSSSSLPYHATTSTASTALPNEQQQRYFDLLNAAAAAAATNNGPFPPTPPSTAFLPGRTSVDIASQSQRPTTATATTTTTTTSKAPTPLWPSLGHHHHYPGSTANSSPIVPDPFKSLQDISLRAGLVTPDRESIFSRYSLLNSSGGGASILEKLNKEQIEKLEMLQTNEKKSDNNKSTRSHHSATVHLGLAPNNLSTTAGPSSSAYSPYPPQPQPPPPPLNHHSYLNSWYMPPPPPTASLFGAAAHHQQFAAAAGMFGSSTSMGRHHNPFAASEASTSSSMMNFMKAAGLAESGYGSTTAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF80</accession>
    <name>A0A922IF80_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF80"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="107" mass="12359" checksum="A4158BCF56989240" modified="2023-02-22" version="1">MNLTNEDELMKFIYTTNKLDLFCISETQTTEKSVLIEKKILKESQIAKSATTHNPTTKKNSQINAIFFFKKASVSSIKEKILRWILNEKLPFTTFIFVQCCCSVLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IFH2</accession>
    <name>A0A922IFH2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">tRNA pseudouridine synthase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PUS1_1</name>
        <name evidence="7" type="ORF">DERF_003877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IFH2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9530038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="206" mass="23955" checksum="A3C536138E5415C5" modified="2023-02-22" version="1">MKFLIETMGKAKKWVVCLGYSGRGYYGMQTQRRDNKVVDDLPTIESELLKAFLQTELINENEYHSPSLMYFQRAARTDKGVSALKQIISMNSSADLKLYLPKINEKLPNQIRIFGAKRSTKYFDSKNFCDCRTYSYLMPSFTIGPNLDESYRVSNEMIEKFNSILKQYVGTHNFHNFTSQKKPLDPSAKRYIISFDCSQPFLLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IGJ1</accession>
    <name>A0A922IGJ1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Glyoxalase domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GLOD4</name>
        <name evidence="5" type="ORF">DERF_004028</name>
        <name evidence="4" type="ORF">HUG17_9449</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7638343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IGJ1"/>
    <dbReference type="OrthoDB" id="1545884at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16357">
        <property type="entry name" value="GLOD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043193">
        <property type="entry name" value="GLOD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043194">
        <property type="entry name" value="GLOD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46466:SF1">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21701">
        <property type="entry name" value="GLOD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="136"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7638343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9530205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="298" mass="33949" checksum="EE05C81F6259776C" modified="2023-02-22" version="1">MTRRALHYVLKIGNRAKNVQFFRDLLGMKVLRHEEFHEMCEAQCNGPYDGKWSKTMIGYGPEDEHFVLELTYNYGIGNYKLGNDLQSIRIESKSAYENVNKQKDVVFMHKNPECIVLNSPDGYLFEVFNPDHDRSSITKVSLSTTDTEKSKNYWHGLLGMNLLEGNEKSFIASFGDKDARLEMVLTTGNQPVRHEQAYGRIAFACPESELPEIQERMDANKETILTRLISLDTPGKATVEVVILADPDGHEICFVGQKGFEQLSKVDPKGNDLLEEAMAADKSDEWFEKRGTAKEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KT32</accession>
    <name>A0A922KT32_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KT32"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9491139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="92" mass="10829" checksum="BE2ED4688FD496CC" modified="2023-02-22" version="1" fragment="single">MKMIGQPISIHHHHLKLKKKTRLENCGNIHQTSSSSSSLHHHPHHSMHHHHHHTPSSHHHLHHHHPSNHNIHHHHSNHMTQYHPINTSSNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KTA3</accession>
    <name>A0A922KTA3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_015976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KTA3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9491244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="212" mass="24945" checksum="5F307B3BBC0664DF" modified="2023-02-22" version="1">MFAAHAIKIIQEINELEAKFEQLEKIRKDFAELKKSTEKRIDELNKQHESRMIEVTGQFKKKLNEANGQNVLLNAKLKQSELEKKNYSSLFTITLFILLFLGVAFYQKTKTHENAIQREKEFQRELIVEKFTEKISYLQKLLNKIRDKYKHLTKIIEPLQQSKSKKKNIQPAHNWISNIPISSMMGMMFFNLMTIIIVITFIGLIIKKLTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KWA2</accession>
    <name>A0A922KWA2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 22">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="22">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">DERF_014112</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="24" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="24">Derf</strain>
            <tissue evidence="24">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.</text>
            <dbReference type="EC" id="3.4.15.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="22">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 21 22">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="22"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KWA2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1370.30:FF:000004">
        <property type="entry name" value="Angiotensin-converting enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF27">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 22" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9 18 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14 22" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 22" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 22" id="KW-0645">Protease</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 23" id="KW-0732">Signal</keyword>
    <keyword evidence="7 17 22" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037220057" description="Angiotensin-converting enzyme" evidence="23">
        <location>
            <begin position="29"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="13">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="15">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="13">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="15">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="14">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="19">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18 21">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KAH9493360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="646" mass="75516" checksum="BF1EECE09EFAE18B" modified="2023-02-22" version="1">MTSIRLSVIRLPLFLLLLSTLIGKFANGEEEIPISSTTAATDEPTTTFESRIINTDELIADEDKGREFMLEFDRRMEELNYEIVEANFNFSTNITATNQARLLEVTKKLNREQKEIWKQAIRYDYKTFQDPLLRRQFEKISVLGIPALDEEDSVLFTNITTELTKTYDQASICLADKCGLDLDPDLVKIMARSRDYEKLKEVWIKWREQAGRPNRERYLEYIRLGNKAAIVNGFKTLDDLWLFPWETPNFKQQVANIWNELQPFYQKIHAYVRMRLREFYGQERMPKDGTIPAHILGNMWSQSWGNIYDIVAPYPNRKSLDVTDTMVEQNYTAMDMFRLAEKFFIDLSLIPMPDRFWQLSMFTKPMDRKVACHATAWDFYNRKDFRVKMCTSVNMKDLITVHHEMGHIQYYLQYKDQPVAFREGANPGFHEAVGDLLALSVSTPNHLKKINLLAENDSMANDPEMILNYQLKMALDKLAFLPFGYLMDAYRWDLFSGKIPAEKMNKQWWWYRINYQGISPPISRNETDFDAGAKFHVPAGVEYIRYFVSFIIQFQFHKALCDIAQPDVPLYQCDIDGNHKAGEHLARMLRLGSSVRWPEAMKLMTGSETMTAGPLIEYFQPLFKWLDQQIANETLGWLVDVSNYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY00</accession>
    <name>A0A922KY00_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0462 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY00"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31475">
        <property type="entry name" value="UPF0462 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31475:SF5">
        <property type="entry name" value="UPF0462 PROTEIN C4ORF33 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9501332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="190" mass="22143" checksum="95F7BD6BCBC327F2" modified="2023-02-22" version="1">MTMSSTYSTRIKTTWNNESIAAEQFISISMHYSGEDLIILIHAPFYNDPVLPDWSKKPGTFDKLYEYEVVELFLLNSQNEHYLEIELAPRGQYLLLELNGYRNVTRTPISLKSYDVKIQHDKHWSGRAIVSHDDLPYGIDKFNAYAIHGSGSNRTYLSLFPAPHNNPNYSEPDFHRLELFKPISLFRPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY36</accession>
    <name>A0A922KY36_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_012254</name>
        <name evidence="2" type="ORF">HUG17_9020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000008">
        <property type="protein sequence ID" value="KAH7637916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY36"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7637916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="163" mass="18342" checksum="F26C48C993C1EDFC" modified="2023-02-22" version="1">MNSTTTTIVLCAIIFVMIVFLIDYSEQYPYRNGGGYSNFGYGNNVGMMNRNGGGGTGYYDQNRMMGIGMGQQQSFGRGNYGGSMPMYGHGMTMMGFEQPESKIRILNREKRNSRYNSETHQAPQIVPIMPYQSQNDDMDWFTMFLAMLLLPIRGLFGGVGRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KY78</accession>
    <name>A0A922KY78_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuropeptide Y receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GPR83_7</name>
        <name evidence="12" type="ORF">DERF_015862</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KY78"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="66"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="665"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="669"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9491127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="691" mass="82030" checksum="CCDBC94554E3E422" modified="2023-02-22" version="1" fragment="single">HESTTTTTTMNNISDNQLMNNNNSHVIINDDIDDDEDRLNHLKLLREDIRMLTNDTYRNERIFYGIAYLCIIILSFFGNLLVCKICWQKLTKTNTLIISMAISDLLMTIFNIPFNFFRIVNFSWPFGQIVCFVVNFVQHCAVYISTYTMAIIALQRYYSNKNDNNVDDDHDHDQNNFSTFFQYYRQKYSTVFSCCMAPIRLLKRFYNQHLDKIIRLLFYHQHRNHQKQHNDDQHKNITTITDDSFSMRTIYLFIIIIWIISSLFSWLLTYSSVVVMKKDASYILEILVRGLYEDSSSSSMIENSNDTDNIDDDYGMIINSNNKNRSNFLENFLIDQQQEQNHIYRCRNPINNDIENFIQQTFHIKADLFKTIIVFITQYFIPLSTICYLYIEIGKIIHQQGKLCNVKGNAKTRIRQRKKNRRLLMLILMVMVFAICWLPLHLFHILIDIGLIDYNYRIFMMVHWLAMSSVSYNPFIYCWLNKNFRHTTISIFCFCFKNNNNNNGCNNNNNHNSDHNNRQNLHRILNQNHDNDNNRVIEKKVVDVNTEFDDHGHHCYQNNVITNDDHKNNDDDDDDRIHQDLSLIDNSIEQLQQQNSSINQCEQQIDSINHIFGCFHRQHSNDDHDGGQQQNDGSHRKRFGTYPQQHYQQYRLKTKSLSIRQEKSIENNNLDDDDDDDDYDGESNTMNTSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZR5</accession>
    <name>A0A922KZR5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_012114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZR5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037691169" description="Chitin-binding type-2 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="3">
        <location>
            <begin position="139"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9501256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="407" mass="45582" checksum="4D6697E7914BAB48" modified="2023-02-22" version="1">MKYSIIIIVSISILVSIIGDHIVHCVYGDGTIIVQNFTSKIVDNDESSTSTSDNDNDNDGTENSETFIGSGGLNSALTSSLMFPQQHQQQQQLQQPQLQQPQLSLSMPFTYQTQTFSDNTTNTDKDRTLIIPAPGSSTGFVCPTPFGRFRYELCEYYYVCFFGYPFLIKCHPAKRFDIRVKMCVSWQQAYCQDVIATIGPPAPIPPGEPPMLPTIIPQQPKPFIMQPIRTRPPPIRRPPNGFFRPPPPPPQQFPHISHIPHIPQIPQYPQYPRPPYIPTMSGIPNGMPAMPMIPQLPTVSGVPMLPGIMKDQHQPIMGDMNNNNQQMEFPMNNQIFNGNNQCPPPSSSNRVGKKLVHHHQVDNNNNTLNDTTNLNERSFGLLFGNNNNNNGDDNDGDDGDKNDIIWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L0L1</accession>
    <name>A0A922L0L1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L0L1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964:SF1">
        <property type="entry name" value="RE45066P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33964">
        <property type="entry name" value="RE45066P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037274771" evidence="1">
        <location>
            <begin position="25"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="267" mass="30946" checksum="4683963562A2246B" modified="2023-02-22" version="1">MKPTNVSLLLFIIVCVEYVRICYARHYPKCHLIEMEKCFDKLHQLKDSQHDPSFLLTSHDGLDKICRVLKQDFTECILAYLKKCGTPLHKELSKVISDAILEHMNKICDSNSEFRNDLLEKSPCIHEKILSQPDYQKECNNPFFTTVAWGEMKAHSKQRERSPIDYAVDAGCCAYRQWELCTMPKIRENCEIDSEDILQNVISKLLGGVTNFLCYQDIFNPESETCTSLPTFDEQIAQVNMTYADEQKFSIFSVVKMFLTRVDVTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1J8</accession>
    <name>A0A922L1J8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">DERF_009484</name>
        <name evidence="16" type="ORF">HUG17_7384</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
            <tissue evidence="16">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7637178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1J8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="15">
        <location>
            <begin position="106"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="14">
        <location>
            <begin position="341"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH7637178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9510997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="818" mass="96206" checksum="30ADE423BA5AA93E" modified="2023-02-22" version="1">MQSTNKRQRKSKNQPPPPKILEKLKRNHHHQSHHESLPSSSSFFYTKNSLFFHLIIFILSICIGFFGFSFFIINPNTRQSTFIPFDSNQTFPVYDIFPSSYSNNPYWSSLIPGHYFALRSSRPNSTLVSLMWFRQKLSQNDGGLPIRHLCRQDDKLNTYYWNYNDLHSFGHQTLIDNNLHINTSFIRLNDAIVSRITIIDAFRTKELNSIILYVAAENSNDDNLTLFQDDHNRIWIKVQSIQSENYHLNFRINKGDQILQSFLTTNSSLDRLEQTVKSHLFFYKHDGHTLFVISNSEQENTMYRSNFIAYQVIFNQSIEIDISMFFNDTTESLMSIDDFDYDNEMNKHQQKFQVDFNQKFHFGHQISAEKIHFARTILSNAIGSIGYYYGYSLVDSEQFPIAQPYGPIQLLAVAPSRSVFPRGFLWDEGFQQLLISRWDPKLSMAIIKSWFSLMNENGWIPREVILGDEAISRVPNEYLVQHSSNANPPSLLLSIESLIDRQQFDREWLKEIYPRLFRWYQWFNTTQTGSQKFPFTFRWRGRNSTTKLELNPKTLASGLDDYPRATHPNDDEIHIDLRCWMALASRLMSKISKVLEIDDKFEEYYRILSDNNLLEQLHWSDKYQMFCDKGLHSTNISLKKIHSGNNDDDRSSWVFERQVLTPPHYECVDEFGYISLFPFIMTLLRPDNSKLETILTNIENPEILWTPYGLRSLSQKSSYYKKYNTEHDPPYWRGSIWINMNYLVLKALNHYSKISGPYQTQARQIHSRLKANLVQAIHTEFIRTGYVWEQYQDDNGHGRGAHPFTGWTSLIVLIMADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L2B7</accession>
    <name>A0A922L2B7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L2B7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="312" mass="37469" checksum="A8D8F3FCE4CA0F2B" modified="2023-02-22" version="1">MSLFLYIKVVFRQFKNSLWLLINCLKRLILFVFRRQNQQQLQLQQQHVQNNNSQYDPLDFVVVDKPLINDNATSISSSKTTSSSMMMANDSILNKSDHHHLHQQQQHSKFPNVQSYTEQDIYNYSNYSLTSIKAKQQQQNYSYDLNYSKNRSQNSGTNQTEIDEKEEPDYFQDMVPEFKKPKTIYVNKHDHPMADIHNNDENELNKIERKFRFMQQNQHQQNDPYQMNNNHSSSMLDETKFTNQFGSLDDIDISVNPSQMDMKITSWEEMANEDEELWIDTDQQLETMRRQRREQRLNEHRRQRQLKQLAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3Q8</accession>
    <name>A0A922L3Q8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Teneurin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TENM2_1</name>
        <name evidence="15" type="ORF">DERF_006635</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tenascin family. Teneurin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9515860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008045">
        <property type="term" value="P:motor neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008038">
        <property type="term" value="P:neuron recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000021">
        <property type="entry name" value="Teneurin transmembrane protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000013">
        <property type="entry name" value="Teneurin transmembrane protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057627">
        <property type="entry name" value="FN-plug_TEN1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056822">
        <property type="entry name" value="TEN_NHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056820">
        <property type="entry name" value="TEN_TTR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057629">
        <property type="entry name" value="Teneurin1-4_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032006">
        <property type="entry name" value="TMIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028916">
        <property type="entry name" value="Tox-GHH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF72">
        <property type="entry name" value="TENEURIN-M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24329">
        <property type="entry name" value="FN-plug_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23093">
        <property type="entry name" value="GBD_Tenm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25021">
        <property type="entry name" value="TEN_NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16038">
        <property type="entry name" value="TMIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15636">
        <property type="entry name" value="Tox-GHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25020">
        <property type="entry name" value="TTR_TEN1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2971"/>
            <end position="2993"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="707"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="871"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="226"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1883"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2851"/>
            <end position="2874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2924"/>
            <end position="2943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3135"/>
            <end position="3172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3262"/>
            <end position="3287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3338"/>
            <end position="3560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3588"/>
            <end position="3610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3734"/>
            <end position="3768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="2858"/>
            <end position="2869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3144"/>
            <end position="3169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3269"/>
            <end position="3287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3340"/>
            <end position="3350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="3351"/>
            <end position="3361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3362"/>
            <end position="3372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3385"/>
            <end position="3405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3413"/>
            <end position="3439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3446"/>
            <end position="3519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3535"/>
            <end position="3545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="3546"/>
            <end position="3555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3588"/>
            <end position="3597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3753"/>
            <end position="3768"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="875"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9515860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="3768" mass="422955" checksum="8F0059A374B80F55" modified="2023-02-22" version="1">MIIFTAFYKEYCNRKYEMKMIKLLLFASRADFTFGRSIGRHPMPIPHSEDSETDEYNVIDSDRQYERIGDRGSSTGTTSSSRSSNHNGALVDPLILSQGAHHIHNAHNLFINNNHNKSSQSSSSHTNTMGKQHMPTTVMTTTSAAAVAHPTHYAESAIYRRSRGNGGNGVSGSCLGSPLDSEPPPLIPESQLFISGTNGPNQSVNSLLEQGWKSQHSTLEFGHLNHHHHHQHHLNTQSTPTQPPLSNQNTTILSNLDSTTNTSNATTTTSVHPVNMAPVYESACLMRTASGSLYIPSDNKGAFKPSIQSINEFTIGGTLKKPDRRLPTVGANHSHFSRPLATHLSGSRFRKILSVQWNWKYTAIAFILISMALLIAITYIMSSALSVANMAQNTNCPVMVDDILELNPAAAQQPQPLQPSSSSSTNPGGGGGGGIPIIGIGNNNNFLGRNNFHAGVGVGHSRNPFNNPYPFGTTITTTTTTAATSHHYVPSSISSFTNIQQLGRTYSQRVPSFGYWHLRYHQLEPSLVKFNLSLPSSFSQTNNMGGNSPSVLAIYGNRDKPATHTRYDFVEFIDRVLMATSATASLVIGRQRLKRANEHHSMATMHIIQKEFTKYLDNGIWFLTLYNDAPLYVDVSLDLSLATDELCPFNCRGHGVCIAGHCKCDPGYNGESCDLMTCPVLCSGRGQYLSGECVCNSGWKGKECHIREDECEVPNCNGHGDCIDGTCHCFAGYKGDHCENVDCLDPKCSGHGHCMSGVCICGKGWKGGDCSEPDNEATHCLPDCSGHGNFDLQLQQCICDERWSGSDCSQERCDLDCGTNGHCEDGECVCDEGWSGDKCLTRLCDPRCLEHGQCQNGTCICAKGWNGKHCSLAGCVNDCSEHGECVRQHLTTPNDELLWVCVCEPGYAGLDCSVALESQCGDNIDNDKDGLVDCADPECCQKESVQSFAQKMAFNDSRASVIRGQIVDSGGLGITGVRVGVSTDPFLGFTMTRENGWFDLLVNGGGSVTLHFHREPFKSVQKVVNVPINEIIVLDKISLNLEGQISITNDVDNKKSAICSDHDYDKMKPIVVATWKQPFQNSHSSDQSAVLAESQIVQESIRMPGTGIHLVYHSSRSNGYLSTIELQLTPDKIEPTLRLVYLKISIEGILFEKIFEADPNILYTFAWNRRNVYRQKVYGLANAVIQVGYQYNNCANVIWEMQTVQLAGHDMPISEIGGWNIDVHHRYNFHEGILQKGDGSNVYLKKNSKLLTTSVGDGQQRPLHCSYCNGLAKDQRLLAPVALASAPDGSLYIGDFNLIRRLRPDGTISTVVELSESSVAYKYHLAVGSVDALNHPTIPRNNLEVFVGSGVKCLPGDRTACGDGRSAREAKLSYPKGIVLAPTGELYIADGTNIRMVDTFGIIHTIIGDHYHKSHWKPIPCSGSTPINKLILRWPTQLAISPLDQTLHILDDHMVLKVTNDKRIIIVAGRPSHCPSYIHHRHQTNDSEDKKELSDSKEPLATQVFLETPQAITFGPNGDLYIAESDSQNTNRVRVVSVSDQRISRFAGADINCSCMDVSCKCFSPDDLLAVNAHLSTISSITVTPDGKVHISDQENLRVRTVYSPLPQQNPSTGEYEIVWPETHEVYVFNRHGQHISTKSALTGTLIYSFAYNVNAINGKISSVTDAAGNKIYILRDYSNQVKSIENSQGEKCRLAMNRQGLLASFTTSSNYAIKFNYQGNLDALLTSRTDSWGKSTLYKYDEYGRVIQVVLPTGDVMRLSNRLAFDGTTKLLVTYNDIDLMRLDVGDKYISKNLLQGDEIFTLERLSNINPSTKGSSHKLAMRKRDTSHLEIESMSSPVIADSWSKMSELWPLPSIMRIIYNSENVKRIEWKYFVRRNSPSSMPNKLSGNTGNDPTKKPSLTSIGRKLKFNGNTILSIEYDKDANQQTLFDHSTRPILHMAFDNVARPIKFISNFNLTPVALEYDQFGRLLSWKRGALSLQLSYDLKGRVTSVKHGDGSSTALKYADTTLGPTEIIKDSGSSRYLLQYDANGGLTAIMTPAGHRNELYRQVSLGFYKLLFLPSGFHNPFTIQYDEWGRTITKLLPNNSGRKVMIYNSLGLIQTELCGAEKTEYIYHTGSDLIKSINKASSDNFDYKAEYRHQGSLLKEERIRFNPRTELSNYKLRYKYDGVGHINEVEFELQGRNVETKKLKYSMLTGMEEGVDTFIFKRHSANVVQIGDERLLKTIATDSYGRMVGITFSVWNKELFSQVIQYEPRRSRIAQSRLKYGANYINSNHTYTSSGFLEQVLISGSSSVSNVVARSLFGYDIDGNLKTIQEGDNELKIRRDEAGRARSFGDNGEDLFMIDERGFTISRDSTNKYMLNANGQLTGVMLKDGTQNDLAISYHYDHKNRLMSRFVTSSSNTQNRTQFIYDQTRPSSISHCVIDSRIIGFIYDTNGHLIALTIEGTKYYVASDHLGSPVAVYTGDGVLVKEIIRDVWGKILKDSNPSFWLPIDFRGSIRDPLTGLNHFEDGRVYDASIAQWLTPSWDAFDKDLSNMIHLYRFENNDPVNPAHFVEKMDGSIGSLPMANIESWLQTLGYRLDFIFDEQIETKRHSFMQSPPIITSLNSERKNLIEIFNHLSMIPESKIKLPFNSNPGSFLDMHEISIAIMPSPLSAALISRTPRITTVHSIEIDKNPIINSVLTNVFNGTYSLPFHLVHHSKDEFFFVQPSQNDVHQRMQRDIEQLHKLGSMVNVSKISDSDSSYSTSHLLVNTGNIMLNIRYGASFDEEINRVARLARRKAVQEAWQREIYYLRHSLPGLVKSDWSTEEKKTLLHSGIVREYFGSDIHGIERYPQLADDPTNVRFKRDSSNLLSRKRRNHSRRQQRSSSLLHEKIGSLSRQIIIKMCKQSANMTIKPILILALTFHLLFAKQLIAEAENDDESKQTQMPSSSPTPPPPPPVVICQSPIDLTVDSSWLEQVVFGDFRIWHIMFSCLGILTVIAVLLCCLFRCRIPRTKQEIEADYTRRKITKLINTHLSKIKLEELEFDPSNLLPVLKRVEDLEENRVKKHRSFELRHMNWRQRLKRLFSRKDLSFEEDVDDQKDDIHGVKMSKEEMEKVEKQVESAKIDSTAFNIITDHIAILSNGFESEKDQKKRIKREQKEQKKLEKEKKEKKEMKKLNKESKSQLPTKLIEKDNGKLLELKAAELEKDVNKTNESKSDDIALIMDTVKSEPSTKVDGKSSKLKEIVQSKLMTETTAKKSSKFSLRNTVMGLMSGFLAGGGRSEPKQSEPEPELKTVESSKSSLHEEIVINIGLVGRQTKDDEEIIEREYDNIPEIKVLKESDDAIEDVVDETNIDKNYNEKASKSKSSKSKHKISRMDAIAERNRLQIPEVIISDINVARDSKMKKNSKDLKSKEKEKKISKKKSSRIEAKEHDEKKKKSKDSKQKEIDTQKSKPSKSVLKDKSKKLEKIEKQKSEKEPSKKIEKEKPEKESSKKIEKEKKKIKVKCEKSKKSKELDQKHAKHRDKESKSEVNDQIPPPYPGQSKRVIVFDEQKDKKSSKPKSSKSKLLKSIDEAEIVPTKSSSSTFKLLKKVMEKDKSPRKEKLVELKKQSKIHSSHSDAHDDDERLIHKQLTTVSSSEIEIPVEHVYTDPSTFSQPIQIHHYHHHDKSAGPSTSMFTSQLPVEHVETIEKFAASSPTGDQHRRLIIEKTRNVMFDVGGGHYSRIQSPQHLYPLIEIQPDESQIKMKKKKKVKLSDNVAIAGPKDSNKDKKKDGKSSRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3R0</accession>
    <name>A0A922L3R0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3R0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="153" mass="17309" checksum="8CD1843935E88E48" modified="2023-02-22" version="1">MDKTSEWLLTNEIRLSMAFANSNDSANLADNSPAFGSWLSMWPSKSRQLSSQTVKFSHFSANDMSRSLVIASTQCTKLILTNILTIGGLLIYFANDRFDHLAYNFCSIPNHSCELYFLSIRSLRCYGTSKIQLVSFINYHINFGLCFNPVINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L428</accession>
    <name>A0A922L428_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ADCK3</name>
        <name evidence="7" type="ORF">DERF_010707</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L428"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="293"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9505944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="656" mass="74968" checksum="038A4A8F8BC3EF20" modified="2023-02-22" version="1">MSSNYRIFLHFLTTLDDAINVATGLRGNPHLMNRIRQSLNEQSKINVSKLKKFQHHHHHHHHRNFIDPNSVIDDVTIVAEGLRQYANYVAKHSVKVDPTIKMTPTLDLTTLIPQSQSSVMTAKEQKLKTRPMITPTMNPIEPLAKQNNFRRSISEPTTTGGGSTFRPDYMAQKKSLNEAAALKLSEKSRERKVPANRLSRVLSFGGLAVSMGFSAAEELAKRIVVGAVDNNNNNGKTENSVFATNLFLTKNNAQKIVDTLCQVRGAALKLGQMLSIQDNELLGPELQSIFERVRQSADYMPKSQLEAMVRHELGDNWQSLFSKFDMKPFAAASIGQVHQAQLDDDDGSLVAVKVQYPGVAESIESDIKNVLTIIKYANIFPEGLFIDHIMNYAKVELAWEVDYCREAQCQIRYGDLIREHSYPEENLRVPRVYESLSTRKVLTTELISGIPIDKLDDFNETSDPAVKNSVMERILRLFFRELFVFNYMQTDPNWSNFFYDYTTDTLSLIDFGNCRPFSEQFVMKYREIIEAAIENDRQTILDKSLEIGFLTGYETEMFKNAHADSVLIIGEALRISDRFDFSRQSVIKRINNQLPILLKHRLKPPPEEIYSLHRKLSGLFLLCCKLKVQVNCRAIYDDVVDQMIRLKQQQQHQSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L531</accession>
    <name>A0A922L531_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L531"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9512095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="75" mass="8973" checksum="8B63299A57AE71BA" modified="2023-02-22" version="1">MSHFLTKVPNVGAGSEEYYGHLTFYFWRHLLAPMGIWHYSPDNDYEMFFFTINHLIDSLLKKNHFLCLKNANINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6G6</accession>
    <name>A0A922L6G6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6G6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="102" mass="11848" checksum="CAF6C3DE995C07E1" modified="2023-02-22" version="1">MHLDDEVAKFFISTKIISTFTNLCCNLKMMMMSMNLVNHTVILLSVIIPIVYGYFSLFLLVSSNSLSADFTWYLVDCDQDTCDTLYILAMTFLSRWFYRNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6W1</accession>
    <name>A0A922L6W1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mesoderm induction early response protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MIER3</name>
        <name evidence="13" type="ORF">DERF_008338</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6W1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045787">
        <property type="entry name" value="MIER1/3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF28">
        <property type="entry name" value="ELM2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19426">
        <property type="entry name" value="MIER1_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ELM2" evidence="11">
        <location>
            <begin position="162"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9517694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="605" mass="67264" checksum="CC75B64C5A205613" modified="2023-02-22" version="1">MAEPNANDSNVSSGGGDDGDVGGGGGGGSCGSDSDQDFDPTAEMLVNDFDDEHTLDEEEALCDDFDDDDDDLSNKDEIEKLNQEKDIPIEELLRMYDNNNNNDQSTSDSSNSNNLNSQTMATASSSTATANTAVNNINQLLSDSSDDDSDEDFSVNEDEWRRTIQVGSDFQAVIPEGLKHYDDSIIVGHHHHNNNLLLWKPILSQLNLDDYLIEYAKLSLSNDEDSSSSLNDFELPTGKHFKDDEQALFTLFQCKYDWKKALNLHENDDEPKAPISEPMTPWTEEECRAFESGLRVLGKDFYQIKHSRIPTRSVGEVVSFYYLWKKTERHDIFANKFRIEKKKYSLHPGTTDYMDRFLDEQENVSINMPFNNNSNTLTMSNPNVQINVQQPQQTQNNSSSSNHHSHHHNHHHHSHHHNHHHGMNISLQQQQQQSSSSSSSSSNRQSLHHHSHHAQQTTTPSSSHYHHPHHHHSHHNTNSNNMSLGRTIQVSNEPQTILINDYHVSSNDDKPIVVCTSGGMGSSGSLNRGNYYGSTSGSINESSSSSSPNTTTIVVGKNPVVIDGTWVSSSASSSSSTTTTATNLTPSVSIYKIPHTSSSSSSFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6W8</accession>
    <name>A0A922L6W8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA endoribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SWT1_2</name>
        <name evidence="3" type="ORF">DERF_010434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6W8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="87"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9512018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="442" mass="50994" checksum="4A27708F541E0229" modified="2023-02-22" version="1">MSGSKIEIELMDVDDLCPVQVQKTNTNTKPQAKTDSKHEDGIQINVQSSLSSLLIDSTEKLPNRRILKAKRNFSRVQTKNGDHIHYLILVIDTNVLVEDLNLLKRLIIKFNINNVQIHKIIIPWTVIQELDGLKLDRNNYLVRKVQNVIRFINEQLKLGEHSRLICLEKSFQNQNEKDVFSNNDDLILGFCIQFNKNPQKFLPTLTIEKQWILIALITNDINLQNKAIVHQMNCYSLKELIQKYKSPDKTIQINSKREAANSSDKSKRVKTDISATSFRNPSKRFRTISQSSSVDLVKEFPRKNHLTTVSTKMDLPSPSPMDPMTSGSCKELDSKYALETRLAEFIIAKFKETFGNDLWQSTLGVYSPESATLIDSLRKFKSNWVGVFSDYFRRDKKVIQLVNEMLQSVNNRTAENCEKLLQMIELAFKSQVGQRENKWNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L6Y6</accession>
    <name>A0A922L6Y6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">VPS41_2</name>
        <name evidence="4" type="ORF">DERF_008416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L6Y6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="CHCR" evidence="3">
        <location>
            <begin position="278"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9517784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="560" mass="65875" checksum="9E92FD1D6B94FA61" modified="2023-02-22" version="1">MVEPKNADIFTDISDDILTPNEFLKTVQKTRDIQMIHYREENGYLIIFPRDLIIARPRDEDDSIDWLLSRKKFRKAFQRMKTNRMNNRQCFRHTYESVGQLFIKHLLVEATLDSCEEAGKICHELCLKNWNLWEIHLNLFRQHHCIRVLAKYLPIGLDNQRLLAPHLYEMVLIEFLDQDDSNGFLRTIRSLPLHLYSTDSMIDRLTTKLSSQLQQDHNLLESLAEMYIYECRYQKALFIFLQTGNAKRVFDLIWKHRLLHLVEDRIVELLELDAEETSRLLIANQDLIPCDKVITRLRKHPRLLCAYLDRLIQRDPVACTRYHDLLFDLYAKHIPDRIVPFLRQSNYIQLEKALEVCKKQQLTKAVVFILGRMGNTHEALRIIIDKTDDINAAIDFCKEHGDADLWAELMDISVSKTNLLSKLLREVGTNATDPISLISRIPEGVSIPDLVPSLVQILQDYRLMVTLEDGCRRVLNSDCYQQFSKMYRMRSKAVVVRDHERYCYSCQVPGILTHHHHHNHQAMITTYGEYVLFQCGHLFHTNCLDFTADVNINMLFLFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L830</accession>
    <name>A0A922L830_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_000828</name>
        <name evidence="4" type="ORF">HUG17_8561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7641092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L830"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43264:SF1">
        <property type="entry name" value="INOSINE_URIDINE-PREFERRING NUCLEOSIDE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038277029" description="Inosine/uridine-preferring nucleoside hydrolase domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7641092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9526766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="325" mass="36360" checksum="7C21F8D2E52DC9FC" modified="2023-02-22" version="1">MNKLFVQVVLLIPLVVTTTNAAASTTPVIIDTDCGQYSDDVTAMAIMHSYADQNRAHILAIVANDRYEGIVPVIEAINRYFNRTDIQIGVTKDPNAYDSGRNLTWPDFVIQNYPHPMYGRNDQAENAVSLYRRMLATSADNSVVILSIGFFTNLAHLLDSESDEYSPLSGRRLIQTKVNRMIAMAGNFPNGSEWNIEKQVQASQHVINLWPTSVIFTGAEVGQHLQCGQNIINDTRLANSPIREAWIIQKEQNIPDACFDEVAAFISINGVEPFYKLAYGTMQISSDGKNIWHQSPDNKPTRLAYVKQVASDQQILNVMDPLLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8H6</accession>
    <name>A0A922L8H6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integrin-linked protein kinase pat-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PAT4</name>
        <name evidence="10" type="ORF">DERF_005249</name>
        <name evidence="9" type="ORF">HUG17_3703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8H6"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044231">
        <property type="term" value="C:host cell presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000050">
        <property type="entry name" value="integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000245">
        <property type="entry name" value="Integrin-linked protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF57">
        <property type="entry name" value="INTEGRIN-LINKED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-0401">Integrin</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0528">Neurotoxin</keyword>
    <keyword evidence="5" id="KW-0638">Presynaptic neurotoxin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="6" id="KW-1053">Target membrane</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="193"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7639670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9521607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="453" mass="51437" checksum="84AF121F6191A747" modified="2023-02-22" version="1">MDDIFHWCKDGNALLVRVWLDDIANDMNQGDDHGFSPLHWAAFSGHLPIVEMLIAKGARLNATNMGDDTALHLASAHGHRDVVNLLIKNRADYNLLNEHGNTPLHYACFWGYKDVAEDLINAGAICNIANKYGEIPFDKCKGMLREDLEQLAMRNGQDLSRKFPYKDQAWYGTTKRSRDATLSRFAGLKLEELLLKQKMATTASGETWHGIWQRNKTEICAKFLAVSGEMSSRIPRDFAEEYPRLRIFSHPNVLPVIGCVNSPPNLVVVNQWMPYGSLYKVLHEGSPIVVDTQRALQFAIDIARGMSFLHTLNPLIPRFYLSSKHIMIDEDLTARINMADAKFSFQEKNKFYNPGWMSPEALQKKHSEINIAKSDMWSFAILLWELATRQVPFAEFPPMEIGMKIALEALRVSIPPGISPQMARLIKICMNEDPGKRPSFDQIIPILEKMRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8H8</accession>
    <name>A0A922L8H8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Follistatin- protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FSTL5</name>
        <name evidence="7" type="ORF">DERF_001262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8H8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053019">
        <property type="entry name" value="GATA_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353:SF23">
        <property type="entry name" value="PROTEIN HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353">
        <property type="entry name" value="RAB-GAP/TBC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="56"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="354"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="432"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="734"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="925"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="930"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9527231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1075" mass="122366" checksum="B483F814511739EF" modified="2023-02-22" version="1">MKQTTIHHHHHHHTKHHHHSKITTTTTISLFNFFIHLLLISFTLLLLIGLTESKTHHRRFSCSAQQTERCPIHKHKICGSDGKLYPSRCHLRRAACDTNTLIRPAHPDQCLRDEENDNNNNNNDDDNDNNENSKIFHLNNNDDNNIRSHNNNDDDNNDLDVEIDSLSSSSSSYATAASSSSQSTNNIIDDSSINSINRYDHQKQQHHHHHNHHQKNADNNNDENGDDDDDNDNNDDNGDDDVDDDDEVECRPKQYDLMKEKILEKINDVSLLFTRLDENSDGQITLNELWKHSMIYKSPDSVCLLTDLMQHEDVDDDDKLDYTEFQAAFNKLFSVSMVTLDESLAINKIEAHLGDNVEIRCDINGEPQKPAIKWYRHGVDLATLNLPYIKVFNDGSLYLTDLKLSFSGNYSCQAVNNPTVKQTHIVDVIVDPIVEVSPRFQWTPIGGVASFECRFETFEDDFTVHWFKNDEQLIDGPKVTIINNGTLLQVAALEQIDTGAYTCRITHKNGAFGQSVASLLVQDESVESSADIYDSHPQRLWIFHANGLTIYEGICGQTIHEIDARDIIYQNSLTLCGNGYNNNDQSSSSSSTTMIQCDWSEDIVQLNGLIYIAQPNLNRILVLHELQLSIVQVIATDPQPRRLRIVESSEMGKDPQIWVLCDGNNNNNDYNYYNNDEQRSSNIPKDLIESEWKDLGDYSVSSSSSVGSKFDYLNEKYRKNRKTIQVIRLMHDAGSSPLSSSPGKQSSSQQQQSPQVQSLMHHHIDVIHLQPVDGHFDLVYDFFIPEHYESIFKNEYNKRMKKVMHDSPYAYATHWEERSLIKISINQLEYIHSIRLNDCQPIAASIITRKAGGLLAVQCQTPITHQLNGQLILDQVTDAILLHNSHLNAHKSYLSPDHRYLVSIYHDFANSTQCQHDETGTTTLCPSQYRSSSSSSRKTTRTTNTNTMATNTSTIIVQKINDNGIEFMYDVRTSLDIVNCLFVWKNGNYDLILASATPNREDLLYLSLIDGHVELISGIGRPTEGYHRGMALSEKNRILSITATESVYTVDLVTNRILCESNKHFQKPKTMIWTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8Y2</accession>
    <name>A0A922L8Y2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8Y2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="8891" checksum="665E13DC8CDEA712" modified="2023-02-22" version="1">MLLPQFSISRYTTTTTEYQSFPLPFRLQSLIRGFAEKIIDYRVLKEKFRNHSKFICLAFMYYDNIIATNNRSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L916</accession>
    <name>A0A922L916_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Microtubule-associated protein Bicaudal-D, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BICD1_1</name>
        <name evidence="5" type="ORF">DERF_001096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L916"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034452">
        <property type="term" value="F:dynactin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072393">
        <property type="term" value="P:microtubule anchoring at microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018477">
        <property type="entry name" value="BICD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233">
        <property type="entry name" value="BICAUDAL D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31233:SF6">
        <property type="entry name" value="PROTEIN BICAUDAL D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09730">
        <property type="entry name" value="BicD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="743"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="133"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="365"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="610"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="743"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9527049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="788" mass="92007" checksum="B662895706275667" modified="2023-02-22" version="1">MIMDTNDSIQQRDNEIQNLKERIEQLNEELKTATAEKIQSAQYGLVLLDEKEELQKKYDELESRYDSKNKDFEDLKEVRFIQSNDRRFHFIFCSQALNKLQTIQRVSATSEIEQEEQLLLESAKKEEHFIRTVIELGKELKYAKNELQNVKDDRDKFGQENIKLMERKEINERERKKILDELKESKQRESRLHLELNELEEENISLQKQVSSLKSSQIDFETFKLEIQRLQSEIDILQTQIEECTKLKSIAEKQTKEALEALQLEREQKYAIKKELDKKLNSESYLNINNFVGFTGLKFDYDETENFDGTIGMDDDNDDDGGNGGGNNSALKKLENEFLNSSDNYLTQPPSLEGSLFSEVHINEIKKFERMLEESDSQKHQLNQRLNDTQTMLEKAREELKIQTVKIEKIFEELNNLNLDDSNTTMMDMTDPDLLNIKQLIKSKISSIDLNGYRNELEQMKNSINDYQMKTKQYENDCEILAKMINEFYSNSNQTFEELSLVSEELASLYHHICLINGVTPDRVILNHLQPNFDPNRSIDQLKEKLNKVYGILDDIKTVECNNLLDTVKDQIKVLKMAIDKAIENRNFRQKHDDVNNNEQPTSMVSVQDVDDLQDQIVRLKSLLSTKREQIASLRTVLKTNKQTAEVALANLKSKYETEKAVVTETMTKLRNELKALKEDAATFASLRSMFAARCEDYVSQIDELQRKYKASEEEKKTLNSLLRIAIQQKLALTEKLEELEMDKERQSMGKAQNETRRNPKINMRSLNQRLISKTNNNSNSNNQRRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L917</accession>
    <name>A0A922L917_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine rich repeat containing protein 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_001838</name>
        <name evidence="6" type="ORF">HUG17_6843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000009">
        <property type="protein sequence ID" value="KAH7636637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L917"/>
    <dbReference type="OrthoDB" id="5954366at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF196">
        <property type="entry name" value="RETICULON 4 RECEPTOR LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038277019" evidence="5">
        <location>
            <begin position="36"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7636637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9527846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="649" mass="75746" checksum="08156841AF851604" modified="2023-02-22" version="1">MIAIHRIHHRIVGMFELHLMLLFLIDTGPIDRTMALHGLDDSTISLSWPSPFFSKTAPKLLTDNRRYLRYHNLYSGRGHHYLHRQQIIGRSASSITNDSTVIITSPPRSNQMFADASNSNIINRTIITDHFLSLADSFNVHPQQHVDCPPTELVRPCKCIEHRNDLFFRTLLRCNGSDFKYERRFENILLRLSKRLGNRHSKYFDWLHLTNMDTVRKITKHFFAGIRFRHLIIEDAPHLKHLHPASFKLVTNSLRFFYAYNTGLEPYRTQPMKAPLGLMRNLTEVHIASRKNICPPKEIIFPCECNVRKDQLMPFGIDRQILQIRCINQRGIVYNVTNIFNRLQKLVAMNAMNESSSLRKHHPQWYFDEVILRNVTELALNSFGDVAISELHIEHATRLRFIARHAFPENSTMQKLRISGANFSNERLPETFEAINSLKYLRSLFVWSCTVEYIPEMAFSQNQFYLKEIVLYGNNIKAIGSYAFANLPNLEELRIDGNNIILVDKYAFATNYTSFHPLRLTMVANNLNENSFAFMAMNGAQRPVHLSFAEIGGCYWNMKYLDEQIFAPFLDKSTNRVYIEPECELQCNDCRMKWLIEIPKHAQKRITLLTDSNYRSIYNVTNEGYVPCENGVNLYDNLNQWIIEWNNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L929</accession>
    <name>A0A922L929_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">DERF_005814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L929"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9522222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="51665" checksum="8285C971EBA8ECBA" modified="2023-02-22" version="1">MSISSKRILAVPVLGVGHVNACAGVSLPLLKRGHRVVFFLEKQFAGKISELGFEEIVYEIDYEPDDTAGTNNKTPGEQTAHFLLTKGVLGNKNRLSQIERLADIPWDSDSKRIQIDRHLRNAIQTFKPDLFIVDNHKLQPAIFYSGKPWINVISIVPLLYLNDIESLPPAWSGLSTDSDRKQWPKYREVLNHIFYDKKLNDLIEKMGYKRYPNDFLMPKTESLTIYSFPEEYDYPEIKQCHPDWFNIEVFNKIKKHDNIDIKELVPKEFYDDYLDGYFTGKWIYVSMGSMGSVDLDLMHRLIDALSKTNHKYIVSKGPRHEEYELKRNLWGDRYLPQMKILTVVDLVITHGGNNTVTETFAYGKPMIVMPMFVDQHDNAQRLSEKKLAIKIDPYDFNDEQLIKAIDQILNDEQLKRRLLSASNRIQNSPRHEQLCDKIEEILSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9P3</accession>
    <name>A0A922L9P3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_002476</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9P3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06956">
        <property type="entry name" value="NR_DBD_RXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000052">
        <property type="entry name" value="Ultraspiracle nuclear receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="10">
        <location>
            <begin position="415"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="11">
        <location>
            <begin position="504"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="291"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9528536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="726" mass="82114" checksum="5D572046E714BF29" modified="2023-02-22" version="1">MTSSMMNNHNLSMDIDNGHHQNDVDGHCHGHNIQQQQQQHYQLFCDITALHCSGFNGTINVNNNNSNDDDQRIQQQQSDNHHHHHHHDAKMIVPKLFSSYHHHHHHDIDEENGSSGGNGSYEMISNYHHHHLENSSSSTTATNHMMTNSYAYHHQQQQHHFHHHGHGHHPDTASFQMFYYPYHHHRHHHHTNHLNSLNDTNSTQFYIQNFNNDHHHHHHQSQELSKNVYYQQQQQHSSIQQSETLNWINSQNFQSKFSSSASSAANGIITTTTTATITNGSGPNSVVSSIASISPSSSSTNVFSPYPSTTATTTVPVTSSSSTQSISLFPSSSSSINNNMSSTTTTAATSSSTTTSPQMNNGNGNSNGGNNQIVASSVGSPQSTTNNNNSSSSSTANNNQSGGSYPPNHPLSGSKHLCAICGDRASGKHYGCKGFFKRTVRKDLFYACREERSCIIDKKQRNRCQYCRYQKCLQMGMKREAVQEERQRTKEKNDNEVESTSNYNHDLLLQQIREAEMRIDIKLRKERITDITDAVKQQVAQLFEWARMIPHFSELHLDDQVSLMKSGWNELLIAEFAHRSIEADKVLVLSNGFYINEQAAKSTGIGEVFQRVLTELVSKMREMQMDKTEIGCLRSVVLFNSEMKNLKSVSNVEQYRDKVYAALEEHCKSHYPNQPGRFAKLLLRLPPLRSIGLKCVDHLFVKQLGLLNKNIDDYILENLESPSINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9Q7</accession>
    <name>A0A922L9Q7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Plexin domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PLXDC2</name>
        <name evidence="11" type="ORF">DERF_008914</name>
        <name evidence="10" type="ORF">HUG17_4742</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9Q7"/>
    <dbReference type="OrthoDB" id="6285106at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031152">
        <property type="entry name" value="PLXDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055:SF12">
        <property type="entry name" value="LD40707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055">
        <property type="entry name" value="TUMOR ENDOTHELIAL MARKER 7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038277037" evidence="9">
        <location>
            <begin position="26"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7641697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9518322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="546" mass="62050" checksum="C675AAEC88ED378F" modified="2023-02-22" version="1">MDHLKLASILLLLLIVAQSILHVYCLDNDESETSKLKNTGKKATLVEKKLDAKLIKQSQQQPSLLEPTKALSSSSSYNGRDLINQTTDETTIMTTDDDFDENKAFHEYEEEFHRNNSEAVLKMNFSYFEMEFIQDPAKAMSKWIDVKSFNDSNYKHEVLSNSHRRAAAISLPFNFSFYGHDLTKITVATGGFLYMGEHVHAWLAATQYIAPLMANFDTRNSSRAQILYGFNSTVFVVQWDNVRLQGDPDKEFTFQCSIYSNGDIAFVYKKIPVPIDHINENEHPVKVGVSDAYFIHRQQIFVRRKTIYEYHKIDLRKNEANINIKDNTAIFLKALPTCSQFKDCQSCLTGNSSFSCVWCDAVKRCSDGYDRLRQEWVLHQCDHKATNEVGKCAAPIVPSSPQFPTSSIFNQSTTNGNTNMITPSPTVFHNSNSTAVINEHRGNIPSSDNIDIHSDKKNLTNLEYNTQEQRIGGNMSASNKNRTPTAHSSLAISLFFIISLTLGLSLWIIYAYRNPTSSSGLFLIRWRPSAWRWNTDTRYTAASIHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA05</accession>
    <name>A0A922LA05_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_001808</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042575">
        <property type="term" value="C:DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1671"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="2023"/>
            <end position="2045"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="11">
        <location>
            <begin position="818"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="1332"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="500"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9527813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2071" mass="242254" checksum="84A02E5F5787E0B8" modified="2023-02-22" version="1">MATTKSKIKQTKEDLERLHSELQELKLEVNHPEFQKDKEYLKDRLTKLRDELAGIMALREEWSKQGLSNLPNLETGTACHLLVAEISNMIGGSVITTSFDTVGRTASVPIVTTSSITDLQLFKSKDPIASAPPSFITSQPGPSGVLQGKQSDIFTTAKIFTPKAPSTLKSIFKPILSPIIPKPTVQFQTQHTPITTSQTQLFETIDFTNPIQDGQYQETIVHSPPVYPFQYEQNLESEPRYTRPFNLKWADKVPKFDGSYLNFHSFINTFNHHVHCTDCDESGKLLILREKLDPKSLQLIAGIHEPYYMLAYNILIKHYSETHPLQQKLKAKVEELPEVRMWFQTEKMRENLAVIKDVYYVLEQSESNRSFLETEFYYIIASKFPRDAVKDLMQKFGSKLTVKQYLTNLSMYIDQNEKQQTILSKTNYMSIRSNQRQTFRQPQSSSQNPFSRNMNPNRFNRNQSTRFTKPWSYSISKQRQQYTQPKVTFPDESPNKPLSIKNNPSSSIPQITYNKNLQQDSRDKNTFQNRNQNEIRKCFFCHQDHIPIKCDKPVKEKRKILNSQKRCMRCFSSFHILNDCPLTFTCRLCKGNHNTSICENKEKYPAHKLNHIKKNEVGPTKILVRLNGHQEFALYDPGASHSFLNSEQCKYLNIPIEPYSSVVKQAVTYSKITGKVNIKVNIGEIEEDHTFYVIPKIKQIIIGIDLIDKFKIIRFPYGKMFQYLEDKIIPIKIEENIDEEEIPSMNVIQKEKINSQQPSIQKILEKYSDVFTDIGEIGQIKEDYCYINLKNNVPINLKPYRTSPHDQQLIDKQIEELLQKKLIQPSVSNYSFPIVLADKKDDGKKTRLCVDYRKLNEVTITESYPMPLIQDIENKLLDATIFTTFDISAGFHHIQMAIEDRYKTAFVTMNEHYEWIVMPFGLKNAPAIFQRIIYKILKAYGLTKFAHNYIDDIVVFSKDLKEHVQHLEEILSVFRGENIILKFSKCKFAATEINYLGHKISHNQIEPLYSNTQSIITMKAPNNLKSLRRFIGKLNFYQRFIPNRTELLAPLYKLLKKNEKFVWSDETDSAFKKVIEILSSRLVLHIFDYTKCTILITDASNIGIGAVLKQKETELDEDNTMVTIGYFSKKLHPYQENYSITEKECLAIIEALQHWHHYLYGNEFIIRTDHKPLKFINSHRNPNTRIMNWALKLSQYNYKIEYIAGKENIEADCLSRDPKFQINLLTLEQISEIQGFVSTSPPNCVMYNGLYVRYTNGRRRYYIPESFAKIMVEYFHKIQGHIGQKQTALHYSQNYYTPNQNEIIHEAVHNCSTCLQAKVPRKKLGKLSQIGPARNPFEYIHIDTIGGLTDRGTTNRYFHVAIDAFTRYVWGLYSKTQNANDFIKLYEEVRKDGIPQKIVSDRYPALSSRRFREYLQVNQTDIIYIPVTHPASNGIVERFVQTFVERVRCKKIDYPNISWYRLAEEILEEYNSTIHTVTGYTPYFLLFAEERYNDYLREPIEDIESYRSDAFVKSSMDHKRNQLYYDKRRKNWQFSIGDWVYAKIADDLNRNKLDPRYEGPFEIINRCSDVIYVLNVAGNESNTPTYPIIWRRSKHHVATEYVQAQVDIHLRSPCDTINSTWISPTKKNRSMEFEEQKIKCEEKYQRLVIQTFQKHCIPLKDKKKFKFKRNIIAFAAGVIITVIVMVATIGYAAYIKSQSGINEQSLTENELKKLDHNIHQKMVDQLILMQQEIDRLKHISSNREISSMFYAKFLQIEMLINEVFIMSSDKPISKAIFQLFENISICVDCPSDNWFLEECQFRPHQSPYESILRLYINAVKIDKEYEIIRADPFYLLVNDHLNKSNFCISKYTGSKYAIINKRTKCARNIIFEPINDHQAPFIFHSVNCKNDTNSVEAKWKAVECKAKELITPEEIVQVKSDNDFVYFYCYNQNITVQGMTYPCKNQIYRINRGQNLTINRQTVYFTKMKIDLHHIIHDDINEILNFQAFNSFNSTINLHDLSTMIEKEDTLINKIIYSYIQSYYIYIITIILIILLSITVILIFCQHNKTENYRKIIQEQYRLAAIQSSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LA94</accession>
    <name>A0A922LA94_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LA94"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="52" mass="6236" checksum="AEB76C852F12120A" modified="2023-02-22" version="1">MVLYGKNDHDDGDEELMETRLSRQNYRSTSRYIFMFQNHPFGVITSIEDHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAM6</accession>
    <name>A0A922LAM6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 2 subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EIF2S2_1</name>
        <name evidence="8" type="ORF">DERF_003507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAM6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="7">
        <location>
            <begin position="211"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9529631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="331" mass="38161" checksum="525D31A665C40CF7" modified="2023-02-22" version="1">MADDELDLDLTTKKKKKTKKPYDFTALDDEESSVKTESVNDSNVATETKTNDVPLDDDLDLADFSGLKKKKKKKKPFNLEELENALPSESGEKESPGDEKPDDSQATEAVDDFDLDFSVSKKKKKKKKTTFDLPDQDDFDKENDADADDDLKEDIQFSGGPSKWLDSDRDYTYDELLEMIYNKIKKRILKVNLEVEKNMFYVLHKFFVLVPKKHHLPIFLKFVNRMLHRQSKHLQNFLLTELGTSGSVDANNQLIIKGRFQQKQIESVLRRYIKEYVACQTCRSPETILQKETRLFFLQCESCGSRRSVANIKSGFQAVTGRRSAMRARTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAP6</accession>
    <name>A0A922LAP6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_003561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAP6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9529691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="142" mass="15966" checksum="79A0E3D1DBF96FD0" modified="2023-02-22" version="1">MVGIDSEIAFVILMANFSLSTSVSYCLIFLHSRSIVSGETVMFLAITSPVSSLKIFSIICFWLPVSWSIFRFPKSIKGAKNTCFAKFPEIMKWFFQFHPIGSQCFNQAAFLRTKQDLSSKRPMIKSITDNKRSIGMAPCSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBF1</accession>
    <name>A0A922LBF1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_003333</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBF1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="10">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9529448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="453" mass="51709" checksum="6CC87A58B22F3D57" modified="2023-02-22" version="1">MLKRCWAPCFTLNSGYLALEKGSKLITYYTATIHILFLFYGIYLLMGGQSDAFFSPFFEFSRKDTNILAFLFIAYCIFYLIFCSIGLIHAIHTETRFFFLPWLYFSLFEILFLASFGSFLLYRYYHNKAVSGKLPEGWQRKFDEDGNHVLYYNINTHQATYTDPRLGSAFEVMDYRGIPAMARNKELGPNSTTEDVLEKADLSGEIAIVTGANSGIGFETAKSLALHGAHVIMACRDSSKAHQAIDKIRSCKEEAKLTFLKCDLSSLSSVKQCCDLFSKMNLKLDILILNAAVNELPYTLTENGIETTFQVNHLGHFYMVRFPSNFISFMAYNDSKLCNILTAQYLHRRLCKHNVTVVSCHPGNLVYTNLQRYWWLLRVLYFLFSPFTKSANQGASTVIFCAVTDEIRDIGGLYFNNCQECEPSEKAQDSELADLLADKSNRMIDFAMNFESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBV4</accession>
    <name>A0A922LBV4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">General transcription factor TFIIB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GTF2B_2</name>
        <name evidence="16" type="ORF">DERF_003887</name>
        <name evidence="15" type="ORF">HUG17_5740</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
            <tissue evidence="15">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LBV4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20551">
        <property type="entry name" value="CYCLIN_TFIIB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20552">
        <property type="entry name" value="CYCLIN_TFIIB_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000008">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000019">
        <property type="entry name" value="transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000007">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00782">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="14">
        <location>
            <begin position="5"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH7642693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9530048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="310" mass="33740" checksum="18A6060A8D2D31B3" modified="2023-02-22" version="1">MSRTNKVSCPSHPDAALIEDYRAGDLVCPECGLVVGDRVVDVGSEWRTFSNDKATSDPSRVGAAENPLLEGSDLTTMIGRSSSDAAFNESGQPKYFNRKQMSSSDRALVNTFKEISNMSDKINLTKTIVDRANLLFKQVHDGRTLKGRSNEAIASACLYIACRQEGVPRTFKEICAVSNVSKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLGLSNAVQRAATYIARKAVELDMVPGRSPISVAAAAIYMASQASADKKSQKEIGDIAGVADVTIRQSYKLMIKDAAKLFPADFKFVTPIDQLPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LC10</accession>
    <name>A0A922LC10_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LC10"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="84" mass="9629" checksum="54E16F109CAC1A90" modified="2023-02-22" version="1">MNNEVSKKNNTFTHTHIEYVTKYIKVGLDDPNQSNNNSLVIINGNDTIDNNNRTLLNNLSSSLSTNDQTLFHYDDDLRKKNCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCM1</accession>
    <name>A0A922LCM1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Saccharopine dehydrogenase-like protein oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_000740</name>
        <name evidence="4" type="ORF">HUG17_8490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7641021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCM1"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000178">
        <property type="entry name" value="Saccharopine dehydrogenase-like oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7641021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9526675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="440" mass="49631" checksum="87CE6A740353067E" modified="2023-02-22" version="1">MTSTKEFDVIIFGATGFTGFYVLRELLLSLEQRNHEYQNLKWAIAGRNEQKMSIKLNEVGNELNKNLTDVTKIVADVSNSNSLLEMARRSRLIINCVGPYCHYGRPVVQACVDAGTHHIDISGEPNYIEAMAIDYHHQAKEKGIIILSTCGWDSIPCDLGVHFTKQQFLGRLHSVETFVTTIPGSEGYKINTGTLNSAINGYRTMNQLRAIRRRLYAEVLTKKIPKSRTVLKRKIAPFTRSEISGWNVEFPGSDRSVVQRTQYYNYEHFNEPPLQIQTYFTVGSFTHLIGLIVFAAMFALMTATSFGARLLSEYPEFFTAGAFSKKGPSRTQIESTRFRTTIIGRGWSKRVLEQQQNKDDIDVEPDEEPDETIMVQVSGKDPGYMATSTCLVQAGLTILMESDKIPKGVLTPASAFRNTQLLERLRERDFKIDVVQSIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LDD7</accession>
    <name>A0A922LDD7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_002689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LDD7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9528775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="112" mass="12605" checksum="1BE22817177E1541" modified="2023-02-22" version="1">MLVMCTDSPRVAPVNSHCRVLLSGHHKNIELVNVKNNYARCQQTPSPAQTSLLCRSRSATTNKKYKPDTTSQQEFINTDLSLSISIHPTTNEIITHPTVGSTTSERKWHYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HFD7</accession>
    <name>A0A922HFD7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CNOT11</name>
        <name evidence="10" type="ORF">DERF_015852</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HFD7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15975:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9491117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="864" mass="100632" checksum="A2B18BFFD99A2487" modified="2023-02-22" version="1">MPLDIESFQQILTFLFDESLQSRQFVYIAQAFRYFLQRLKHEQLQQPPSSSSNNGDDGNDEKKEYRFKFEIGRFIVQLLFHHSVLLPKFSQKVIALYLLYDLYNWPVKIYNPFNGIIYDILNISTYKSSAIYFQFIHDFQKFFKEKFQNFQDENLTFFENYFDIIDKFDLLMERRNFIESSSGIEKNLICDYHTNSTILHTKLQVLSKHIKKVIRERLEIRDILRNSDFAKMYDFIERISTQQQHQSLTINHNESRNDNENFDNFSLIDVNINKNNNNTHNVDDNGQQQQQQPQQLLQDPLYSTLCIPKYFMDNFEKPVAVDIYTVFEFPQLPTIAKNYFISLYIIVDELSRQEFLKLSPMDIVSCDFLPQQVSVMKRFRKKFFGENYCFLQHLIFESIYMKQLKQQQQQQQFVECSSSGQNSTSTTMLSSEQPIIMKPITKTEFLSYIEQLMDKSCLYYFPFFPSIKNENEHFDFDDPKEKTNTLLKSLLKSNYDIDVEYFLDNNLVNYYNNQHANHINSSQSFEHFFHHHHHHVNNNDKNNSSLIELPFNVVDGDNNEWQQFSLVNNKDDNNNMNNNNDNGKIDNDGTIIIDSNEIDGNKACNEDENITNLLKKACQQSLTMSEMKSVQSQLKTIPSLSSSLLLLKSILTVVDPTSLPGLVENNPSIAHELLPILIQQSPLKNFLPSTISSSSSSSTLINENKDEIIITMSNIRDYLAALVDMDTSLHSIEVVNKLSTQLLLPEEFTYRYITNCIRTCENIKDRYLQNRLVRLVCVFLTALICKEIIDVRKIFFELQAFCIEFSQIRDAATLFRQLKQLETPPNDSSSTTTTTTMITTTCSNATTAASSSSSSSSAVGDFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HFL1</accession>
    <name>A0A922HFL1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_015896</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HFL1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050457">
        <property type="entry name" value="ZnFinger_BTB_dom_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105">
        <property type="entry name" value="AGAP004733-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46105:SF5">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 44 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="12">
        <location>
            <begin position="118"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="786"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="817"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="526"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="599"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="680"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="898"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="683"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="750"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="920"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1030"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9491164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1054" mass="112357" checksum="6CE2F2F2F28C940C" modified="2023-02-22" version="1">MHTSSLTAPQMETSLESKFSAAFEQQISCSTGSSNKNSLCNGIGGGIGSLSSSSMTTTSKSRHLPSLQSSSSSSSMMGSTNKSNTDQNNGEKTVSFRKGNDLESFESLSSLLANGLFTDLVICCPGRMFKCHRVVMAAASLYIRDALSSFYNNNNDIISLGGSGNGGTGSGGCNNCNTVMILPTEIKMTDMEAILRFIYDGHVEVKVDSIESFLRSARLLNIKGLSNVNIVFNNNGTTTTTTSTTNNEDSISDSGIEVISGAPPSANTTTTAAAAAAAANLLNGHTVGVNSPPPSPPTMMNSSLASLKAMTTPTITPNHHNHHHSHHYEHRNNSNHHNNHHHNHNQSSSSLPNGNHHHHQQQHHNHHINKFLNGMSNQLLLSQYRNNLVVPTSGNKQQRDQSPSLRNESSILGSTTANLTPAHQSSTPKSIYNNGQAAAAAAAFALFNNNIVPPPPPPPPSVNNRFDSSNSSISSSGGGSRRKQKFPTNIHSAQAALALASSLDQMLPQGTSAAALYNTFLNLNSEEDDDDDLDENDDDKRLIIKDDSSNDCNSTIGDNMSTTSIDSKQQSLPFGSIVPSPFAPQVPCMIEVEADPTIIPSFSDYNDQSPSPLQQTQPQSSSSQSSSSQQKRRRTFKPPYSTGSTSGNDNNRMNNENNKRMKLPNSNAVSVALNNSIDVSIKPSSPLMHHHNSNPPSSSSPAGTTVDIVPPKKHNNSVRSSSVPSSEKSQLFSSFSPSIKTTPPGPNHPSASSPSSSTSSASASGGGGGGSSAAAASGGSWVGSKWKCDICNKYYGNKQTLKEHMDYFHSNREEQIYICNICNKEYTWRKSLMKHYRDIHQMRNTPALAEINRQLAALASAKVRTAVANMPMGSGTSPGSAEAAALQSYVSIANFANRKSGHSSKGSSDASEKSNKSESEMDNDNTNDAIGGDDMDDYGNDDLEMDGSVTTDADLPDGDTMSANNDEPMMKLESSTTANDVDDGDNHHNHHQHLNHKNNNEQMNNKSNGDTSSPSSPPSSMMIDEKDSTTIDSSNVPTNLENHSSPASSSSHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HGU7</accession>
    <name>A0A922HGU7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-rRNA-processing protein pno1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PNO1</name>
        <name evidence="7" type="ORF">DERF_014150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HGU7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000048">
        <property type="entry name" value="RNA-binding protein PNO1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PNO1 second type I KH" evidence="6">
        <location>
            <begin position="164"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9493399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="254" mass="29205" checksum="3E49FD7DEDC10B63" modified="2023-02-22" version="1">MADLLDAEMAKIEDYKTEQQQQNHNNEDSEFKVVVGKKSKNKRKLDEMEIDDDNKSLPKLPNFKPVDESSTYSGVEYRKIQVPLNRYKPLKENWLRIFTPIVEHLKLQMRFNIRTKCVEIRTPPGLSDKCNIQKAADFVQAFILGFEIEDALALIRLDEMFIESFEIQDVKRLKGNHLNRAIGRIAGTGGRIKFTIENITKTRIVLADSKIHILGSYNNIRAARTAICNLILGSPPSKVFGNMRQLANRLIEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HH08</accession>
    <name>A0A922HH08_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HH08"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="567" mass="62422" checksum="346F82252C0A4F49" modified="2023-02-22" version="1">MNEEKSLKQQQQQQQQQQQQHQQPTNNDDQKWKRHQFKNLRQKNNPNQSMIMIDMTGNIENLDEPDDDTNEITSILTTATTTAKMMMLQQQQHQQQPQLISDSTTLESTSDVNFGATSPIPTSTATTQQRLYNNRLQQHPPPPLRLKKMSPTFQMYSSGTAIRRTFSIHYDQMIDPSINNSGGSDLLSSSSSSAAAAAAATTSSLPNVNNSGDYRNQKSSTMIKCPSLPNSPLPKSFTLKMATNTTTNTTTTSTTTTTTGKQRRYRLTKRRTMPGRSNSVPFRPEIEQNIKNVDDGDDDDSHCSQTTTTTSSMNATTTSPSTPRSIDTPGSATSTGSSTSSNTSLRKFTYGSMETTSFFHKRFNQTISFLQRQNSSEEAINEQQQHRLQSSPSPSPTAAASTTTTTTTTTTNILRSPLRSNRFLQFSHHKSNSLPANDPTTTTTTSAITTTIATTTAISDLQQHQQQSMMMANLSKTNSTENVLIKQRTIDCSSLSSQITKNDDDDELMTVGKSATTTTTTMSLNVPNIIIIDNDDDNDQFGLGNLGVCDNLYDVGSKTSSIIVGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HHE0</accession>
    <name>A0A922HHE0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HHE0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="69" mass="7968" checksum="A7CAEC6A229B08BA" modified="2023-02-22" version="1">MNTAKTLILINEMNKNEFFDQTVAISEEKIGHFVHSPPPSSSFRSRKSDRQQILNLSENFLSHSITIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HIM1</accession>
    <name>A0A922HIM1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tuftelin-interacting protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TFIP11</name>
        <name evidence="11" type="ORF">DERF_014579</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFP11/STIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HIM1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024933">
        <property type="entry name" value="TFP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017706">
        <property type="entry name" value="TFIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="130"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9493851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="825" mass="96194" checksum="9845804AA6E17705" modified="2023-02-22" version="1">MVDNDNDDDGFIKFEVSDWDLEFGQGNHRPKRMSKNQAIYGIWAESESDDEDGNRRGKKQSNMMDINKTGVSFVKSDQKLQDELKERKPSSSNHEFSKQTQSKKKPSRFSGLGSSSNNADAEFGQWEMYTKGVGSKLLQKMGYQPGKGLGKNLQGIIEPIEAKKRPGTGSIGLYGPETTAKILRKGANDDDDKKQKKDQDETELSTNEKEWKRNDGTKKIKTIKVYEKSTDDIIRDSITKSWTNPTADYLNNMKIIDMTGPQQQILSGLTKLHQSKPAKPKDDYHVTKFNTRFDIPELRNNVERLIMLTEKNLVKRKREYDRNSNQMDNLNEERDRLNQLAIVYQRQLKSIQVIETFVESLEEMKHELSFEKGLEKFENFFTTFSAKDESNIDEQKRLLRSLKFDTLLRSIFGPIIRRELRTWHPFDNFAIDYSGHFDRLRRLMSKSKTFEIILWQHWTPIVSRAIQQISLKLQFESIIAFLEKWQKILPKWLYEYFIANNLLPKMRSEVDEWNPLTDTISIHSWIHPWLPVLLTTTKTTNTSENELNFLFEPIYEIIRSKLANALKNWHPSDCSARLILEPWKNVFTESSMQSFLEMNIVPKLEQSMQQMQINPNQQSLNEWNWTIQWSSLLSTNTIVSILEHTFFPKWLNVLYVWLNSGVANFQEISSWYQGWKTLMGNDLINHIIVKEFLRKALIMMDHAVNLETGLKSFTSYYDPNVGITVNQQQPATTTTTTMMQPPVPPSIVEDKINFRQMIEIKAAEYGILFMPMANRFENGHQIFKFGSSFIYIDNQVIFQNRVQSNGHRLWIPVSLSDLLINSNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HJS6</accession>
    <name>A0A922HJS6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">F5/8 type C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_014713</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036696332" description="F5/8 type C domain-containing protein" evidence="9">
        <location>
            <begin position="29"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="11">
        <location>
            <begin position="106"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="10">
        <location>
            <begin position="1483"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1247"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1259"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9493989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1843" mass="210687" checksum="4E31FD272B03B8C5" modified="2023-02-22" version="1">MLSRNYFATLVIFILILLTIFHCHFVHAKSSSSCKNGNICIHGDCIDNDNGIKNGDSYCKCMPCWHGSHCDQFDDLHEPYFSEKIINLYLKKETIHHHRPIFKAHAYDDDIHNDDCVGLNIENCTCAQIQYEIIEQDEQEIFRINSTTGEIFINKPKLIDNKPLDHYYQQQQQHYKLMIIAMNPNWNELKTIGDYYYRNKNSSRMLTIFVNIQNQLDRIKRQSASSAESDDSSSPSSLSALSSNDDGLELNGINFRLRTVAGETSSLQVGSSIHYKLDIGFPKGSSDLVLDIQTLDSPLSVKRSSLSLYNFSMPYETNDMQFNIPEPKFFLSNKTANVYNRLTLDFGTIKNNGQDRNELSICFSVILFRKPRRAKKKHSLIVGMEHTKGSFTYVAESEITTVSVLNLTLLKNQQKLHLDSAAIFRFDANFQFRSDPVRIELNKTSYEYEPDNRISLGLISVTKFGSNYVTMPSSPHHYIGYRNLSATMQSYTFSTLNMNTVTNNGEKSRLFMKNPDNVISFSFPVYAMNFEENIGRNISFQLDIFVTKRSYFTRIFNMTIVGRNNNERLQSFMIGSAANFTQHDLTKGGLTQLKILSKFRDFKDENVFTDYAITIDGMGTPQLPFIPCSARILYQENGINIPYTNPIMNPFLLDDNDLVAEITFRLPFDSHVKPGEYSIKPEHIQVTSGYETKPLMIMNNQLNILSNENGNNETSSSSSNIELSTNSSVKWSDLIVLGGAAVDVELEFEPNAAFEDFLITISSDMATAADSLPDLKICRFSVIRVAETMPCTCVERETINEKQIVYGYNNRKMSKEENEINTRPYDRARIDFGSISVVNGSNVRQKILTNFAIMIADSGANNGDSEQQQQQQSPKQYPIRVDIISNSASNIQDNIIKSEQINLNISELLPETIAADMSIDLDAELFNETDTFILPGFSTNILIRTLTRPNTIGPLRIEIGGDDDDPNSAISVCGLWIHRIGYNLPCVEANQKAEYAFETFGINKRAVLQLDMITNFGNHRRKSERDERNDNSIEFMAMIRMLDQAENSNQTISIKVIYGHKDITVTKQIIIPNRFPDSLPFIVSGTVLIGHYQRPLETKNELALTVVPNEAGNNSVAHQQQISDHFPITEGARVILAKWNDRREGIGFKIRQRKWIPFRIRIPVYSTGKLSVTIRGQTDENRAYIVLYDLRLVHGGANIPCPLDNEPQIRLNSTVNINQTNLINAELGWFANFGYTYYIDINNNNDNNNNNSEKDQNLDSDNNNDIGNMTNSALNDNDDDADVLTIEVLAELTDHPSLTENDVYRLEFEAHYGNLTNTITTRTEAKIRLSEGEGPNPKLDVNIRYKKRMPVLDRNETFTVMATIRHLPDSNAEPSNPVLRLFTPDFVEISGINWANTRQLPKLKRLADGSTDILFPWILFNEQFIVNFTIQIDPRNIRGYGHKELSIITPFRMMCQHFRVSSDTKFPCSQMKHMNYRTHSTECNNPLGMLDGHIHDDQITASSAIAQRFAPKFARPNSSSSSSWWSPAWRNWRHGHPNQALNNGQNYIQIDFRQKTRLVSIEFKSIKNQRSIHTYHLDYSFDGKVWYQGTNTTKILYNNVDDQNIKAIGESRLQWPIEARLIRIIIDSVSSSKTTKTTTTIMTKKQKIDSNSKGNIHNQYLAVKFELYGCYLKELESSTRPASTESLEFQTHYTDDTTIKNRHISIDPYTNIIYFCDATSNINHYLCYYSDSGGNAWHIVGRSIDSFEGFELATGKFFAIDYDRPAYFYSPDGIIWTPIDYQRFNETVEHPKFQRKMIIPRFSLDDLNKMNVRIGNWRANYQGLNYEDNQYPKALWNKCCGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKG4</accession>
    <name>A0A922HKG4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKG4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9494298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7747" checksum="F9A108FBB93B3053" modified="2023-02-22" version="1">MITLMNDQEIYPKKNIQTDVYIFVVDLFNFLSPRKNMEIMHFCLHFQKNVEIFESPNDDHILID</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HLE1</accession>
    <name>A0A922HLE1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TAF1_1</name>
        <name evidence="12" type="ORF">DERF_013219</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05511">
        <property type="entry name" value="Bromo_TFIID"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1100.10">
        <property type="entry name" value="TAFII-230 TBP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009067">
        <property type="entry name" value="TAF_II_230-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036741">
        <property type="entry name" value="TAFII-230_TBP-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041670">
        <property type="entry name" value="Znf-CCHC_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09247">
        <property type="entry name" value="TBP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15288">
        <property type="entry name" value="zf-CCHC_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47055">
        <property type="entry name" value="TAF(II)230 TBP-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="385"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="507"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="11">
        <location>
            <begin position="2395"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="662"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="762"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="865"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="934"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1194"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1288"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1377"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1516"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1838"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1904"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1959"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2333"/>
            <end position="2361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2576"/>
            <end position="2607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2622"/>
            <end position="2700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="87"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="2100"/>
            <end position="2139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="696"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="790"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="879"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1194"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1292"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1307"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1843"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1904"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1963"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1999"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="2338"/>
            <end position="2353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2580"/>
            <end position="2596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2622"/>
            <end position="2639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="2642"/>
            <end position="2655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="2672"/>
            <end position="2684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="2691"/>
            <end position="2700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9497214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2700" mass="308186" checksum="F9B56447CC14178A" modified="2023-02-22" version="1">MLREESSNQGMSGDSKKRKNDSNADDNDNNDGNALMSSSSSTGRILKIYRTFTDSEGKEYVRIETVRKPAVIDTYVRIRTTKDDAFIKQFASAMDEQQKEEKRKEKRRIQEQLRRMKRNQEREKLANSLRNSFGITTTPNSTMNIGSISGAMPSQPPLIATSTPASLASPFLFNPNLNPMGVGGTPLGTPTTPIDLISSSSSSSKVTKRSSRKDKETNLKLKCGACGSVGHMRTNRACPLYGNPEAGSITFGNGNDLSADDSIGGGGGVIGTNLNQSSTILNEENLVKLDETKLVLSKSVMKQLDLEQQKQQQLELERQQKKAASIKLKIPKDVLKKRKKRSATQDNNDRLDYLQKPDYKSANRRRTDPLVILSDIFEEIWNEMRSMPDSEPFHQPVNVKTVPDYYNIITRPMDLQSIRQNIRNKRYKNREEFLNDVNMIVKNSEIYNGPNHVLSTIARRLMELCVLKIQQKEEELIKLEKVINPLLDEDQTAFSYILKTIVAQKLKTIPDTWSFHKPVNKKTVKNYYDIIKNPMDLDTLEQNATNHVYKTRETFLEHVGLIYENSVRFNGPDSEFTRKAAQIVEVANIELKQYESQLIVLEKAIGDHNITGLDDDMIDDESNMAEEYDDDQQQQSMQPPPAKQARLFQDVDMDENQQDTTDIVADDLQIESGDESDDDDDPESLSGWHDAHHHQQQQQHSFISEQQSSSYHQNVDDFDENYDPSEFLLKSSFAQQSTLYHQQQQQQQKQSFESNRQMAIDDDNIEDDDDNDNDMDHNNQPVVDVSQDLDVSDSDDDDNDGDVAEPNDDDGEEDNDLCRITSVILFGNIDENGELTDDIFDDECRRHLDSLQPHLSSIIPFEDLIEDDDDDDSSQQRQSDNDKRLSDDDDGKGSDSDLDIKSEIAVDYSDINEFVADEEQSFVEDLLNNIIQTNKNDNCDDDDYDDDKNQNLGSQSDGKQKDNQIEIQKDKDGFVIPQQPIRKTDSLTVKSNNIQIEEQQQDHIDGDNEKLCEGSEHQSQTCKKRLDTPLAAMLPSKYADLDVTELFPEFRHNQVLRFSRLFGPGKSSSLPQIWKSVRNKRRNRHIFENKLFIVQQTKTPPIDKNNRDIWEFDACPVEDIPADMIEMDDEIRLMQNDFIDDEHGKNSAGENEDRNKIAEWRYGPARFWYDRMKVPENGDGFDYGFKLKNQDSFIDGDDDNGDENDDNNKDDHCSSATKSKQSPLDNQPLSNDDDDAFHLVTQLNWENEVIWNADEVRQKILAKLNDKHLASGWLPSGHNRTATAFTQQMRGSAAPKSIPIPSSSSFKKNDGKKNAADSYKNDDQDDQWFSIFPIENDDLVYGLWEDSVIWDSEAMDRIPEPPLLVLDRNDENIILEVPNDENPNESNKNQPTKEKKEGIRKSRLLLGKAGVIAEPEILQPPSPPSGEKDPYNISNDEYYAQKTTTDATLKSNVGSNLIQHSIPALELRQPFFPTFLSYQRLRAFHRPSLKRYSHGAIADTLPHGVQPLVKHIKRKAKQREQERQASGGGEMFFMRTPEDLTGKDGDLILTEYSEEHPPLIMQVGMATKIKNYYRRKLGKDSGAPNYKYGETVYCHTSPFLGNLQHGQSQQALENNLFRVPIYEHQLPETDFLVIRTRDNYHIREVETIYTVGQELPLYEVPGPNSKKANNFMRDFLQVFIFRLFWKNNDNPRRIKMEDIKKAFPLHSESSIRKRLKQCADFKRTGMDSNWWVLKSDFRLPSEDEIRAMVSPEACCAYYSMLAAEQRLKDAGYGEKSMFAPDDAEDEDLQVKMDDEVKAAPWNTSRAFVSAMKGKCLLQLTGVADPTGCGEGFSYVRIPNKPQQSKEEQQKEPLPKKTVTGTDADLRRLPLNAAKQLLRKFGVPDDEIKKLSRWEVIDVVRTLSTKQVKQQTGDSNGGQGEDDAMSKFARGNRFSIAEHQERYKEECQRIFDLQNRVLASTEDLSTDEDESEEEEDSEIEELGKNIESMLANKKTINQISRDREEEERRELKKLMLREESSNQGMSGDSKKRKNDSNADDNDNNDGNALMSSSSSTGRILKIYRTFTDSEGKEYVRIETVRKPAVIDTYVRIRTTKDDAFIKQFASAMDEQQKEEKRKEKRRIQEQLRRMKRNQEREKLANSLRNSFGITTTLNSTMNIGSISGAMPSQPPLIATSTPASLASPFLFNPNLNPMGVGGTPLGTPTTPIDLISSSSSKVTKRSSRKDKETNLKLKCGACGSVGHMRTNRACPLYGNPEAGSITFGNGNDLSADDSIGGGGGVIGTNLNQSSTILNEENLVKLDETKLVLSKSVMKQLYLEQQKQQQLELERQQNKAASIKLKKPKDVLKKRKKRSATQDNNDRLDYLQKHYKSANRRRTDPLVILSKIFEEIWNEMRSVPDSEPFHQPVNVKTVPDYYNIITRPMDLQSIRQNIRNERYKNREEFLNDVNMIVKNSQIYNGPNHVLSTIARRLMELCVLKIQQKEEEFIKLEKAICDHNITGLDDMIDDKSNIAEEFDDNQQQQSMKPPPAKQARLFQDDMDENHQDTTDIVAGDLQIESGDESDDDPESLFGWHDVHHHQQQQQHSFISEQQSSSYHQNVDDFDENYDPSEFLLKSSFAQQSSLYHQQQQQKQSFESNRQMAIDDDNIDDDDENDNDMDHNNEPFVDVSQDLDVSDSDDDDDGDVAESNANDGEEDNDLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMF6</accession>
    <name>A0A922HMF6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Low-density lipoprotein receptor domain class A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lrp-1</name>
        <name evidence="12" type="ORF">DERF_013566</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMF6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000005">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037870269" evidence="11">
        <location>
            <begin position="24"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9497589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="400" mass="44929" checksum="0002CBF62F93261F" modified="2023-02-22" version="1">MQIYWTLSLMMMMMILWCSLVHCIGSSIDDIPSAAELFGQEESYHVVECVMPLYFLCQNNNCLPESHLCDGENDCGDNSDEDHDYCAQMKCNVTTEFKCNSGRCVPKASRCDRHPQCRDRSDELNCVYEPCPKGMFSCANHSQCLDMSEVCDGSIDCKDGLASDELHPNPCPANVTCPSSSFKCTGTNVCAQPNWMCDGENDCGDNSDENEENCKNFKCPDDWFRCADNRCILMNNVCNGVIDCKDGLASDERHPDPCPRNVTCPNDFFSCEETNICAHPHWLCDGADDCGDKSDEDIEKCANTPCPEDWFRCSNTQRCIPPNWRCDGSEDCRNGEDEIDCNNDYVHEIFIPENNTLVSYVNHSNNVDLLESISKNLQSINNNDNSSSSNINNQQMLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMR8</accession>
    <name>A0A922HMR8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_014652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMR8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9493927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="68" mass="7634" checksum="EB19D490C9026B2B" modified="2023-02-22" version="1">MHGVETITSNMFVLGKHDNNNKKKYGQKYHHWVTNKQNNDDNIVATTTITTTPLSSSSSSIIIENSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMS9</accession>
    <name>A0A922HMS9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMS9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="720" mass="83934" checksum="2F9B8A51EC0D031E" modified="2023-02-22" version="1">MSSSPPLSSSSSSLSSDESFSKSNILIRDNSVEKPPPPDPERFLSTGLLVWSHRFSDLSSALKMVDNYLVKYDPETDLIIDGDPILPADFCDYIFPIMIGYPNELPIDPKWIKNNINRSMNPGCYLVCARSTSSNCWSSMEQSIKLGVYRTELTTHLTRLDANLLFVMQSACKNDINLNVTQYVDFIDDLDSVRDHFFPHRLSQNMVQVMARSSQACNRQAIRARTHLQKLVDILSREPSDESLSNQSSLEDSSRSSSGGGKEKIKRLLKRHDDLVHIYVEKLLPDLYKVKETFVTKKPKDDRNFYSERFNFFLSKDCFAIILDQNCAFDRLQRKIARESEEKPGPFVRLIRSGAYVAIEGTPRYCNLKNPHHTFYTRSIFLCRLTSFPMVILQEGVKCFDAYYNNDGLDFTYFDSIPINDLLYVDWYQIQIDLKMDQNPRIFKGHIMFWNEMNDILPTLPFTQMKFDPEMAARIQMLCMEEEESRPYRPLIIFTLQQVLYTYYDVLRSRLEILWNLYFRIDDSHIDRLSTAQKLDIVSNGIYFYMKSFNCTYLWTQPNTDTMVKEERNCEITVSSVDVTDMDLAKIGWSHQMFEQFLNLYLGRLYPYQNSIKQWLMDETRRIKRQLIVRPTTLTDKLLYRNGFYQTKIEQFQKEQAQKPRKSFLNMPETIKSSAIYGNNNKKSATGSKKISLQKKSASAKTTTTVMKKQQPEPKNPKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMU2</accession>
    <name>A0A922HMU2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_014750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMU2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF66">
        <property type="entry name" value="TERMINAL URIDYLYLTRANSFERASE TAILOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="8">
        <location>
            <begin position="34"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="7">
        <location>
            <begin position="269"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="602"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9494027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="651" mass="77052" checksum="9918B0BD584BEC46" modified="2023-02-22" version="1">MDDSEFYQQLFSIRDINVDQIWKRLDSEQQITNNDIKECLDKIMFNQEDLSKRKIIRGIFEEMLRQNLIECQVYSFGSTTSGLSSYDSDIDFHVRLFLPNGRIRRLNNKEAEAPLKEMLKIFREKLRCYFHTIFIKASCPIVKLTSFPRNRIKHKIFSCDLNVTNPFGIYNSIFLNFLCQFCPKFQMLTVLLRLWAKNTMLICYEGMNSYTFTMLVLFFFQSEKIFLPIEQLDVNFADHYYETDPDSFKLLIHDKCQALVNDTELSIFNLLLKFFTFYSQFDYYHFVISPRLGCPIRKNEFIDTIINGRYDFKMTNALCLEDPFELERNISKNVSFTKLNQFIQQCEEFKTKDDNFFRNGKNFHKFMTMKNVNLFRMYVPIIPCLCIIRSLLESNDQDLLYNLMVYYGDIITKKFNELYEKKLSIKAIDGYLLIKINEHISAESLKKTLKEYLEKKQKKIIPIIDYTFEMKKKKRKEKIQQQSKRMAVKFDPNIPGPSNISSSIVAKKTSMEIDNDQPKTTDKSNGGKKKLQQQENKILNGVENDDGDDSQETYSELLNFSLVLIPNGENFYYFALKSNRPILIAIQSFLHREICTCQSDRRRKRTENLDKNGNDNNNNNNNNNDSKRKEKKKMKKNKNVQQKPKPKKTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HMV9</accession>
    <name>A0A922HMV9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial ornithine transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_013716</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HMV9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="118"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="216"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9497757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33473" checksum="4B54AC388EA1F477" modified="2023-02-22" version="1">MENESTVDRGHHRDEKQPLNPAIHGAIDLLAGSAGGTANVLVGQPLDTIKVKMQTFPHLYKNTMICFKQTLLKEGVRKGLYAGTLPALLANVAENSVLFCAYGFCQKIVQFATKKDSCNALENATAGFLAAFFSSFTLCPTELIKCKLQALRETGKGSIGAFELTRNILKSEGIPGLFRGLTSTMAREMPGYFFFFGGYEYTKSAMIKYGGQSEELGLMKTTIAGGIGGICLWTSIFPFDVVKSRIQIQSSQESMNKVLLTILRQEGIKGLYNGLTPTLLRTFPSTGALFVAYEYSKLYMTKALLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNE6</accession>
    <name>A0A922HNE6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DiGeorge syndrome critical region protein 14</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Es2 protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DGCR14</name>
        <name evidence="6" type="ORF">DERF_014090</name>
        <name evidence="5" type="ORF">HUG17_4036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
            <tissue evidence="5">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7640003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNE6"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="443"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH7640003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9493336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="497" mass="55949" checksum="492E8E5B8D74E901" modified="2023-02-22" version="1">MDSKTIVPYKDDDDDDKSVEQINDFKLQIISNSSDIDHQTKVKKRKVLDEDEFSRKIGSIIERDFFPDLTKTRLELELQDAIKNNDFEKISRLVRKKIEQNNGKQKNANMTDTPANFCTPASTLNDDEIRFQKIDPRDQEDDEETSDQMNNETNLSLNKFLNKFTSEDSDSFQKLQDKAIKKHLERLEFLNSDSQLNNEIVEQSLELPSIDTQQMIMNANQSTKESQSVANRLVTWKHSNTNTVMFDPEGVKLTKDEIEHFKSRQIIVHENTRFKTNPFQTNVNSQPVNNTNPLQSGKIGVDGKEVNGNKTPSVNGFSFVPSTPCLRPESLANSPLMTWGAIEATPINLKGDTTPLLHSGGGSHFKIPEISEKESIGKELANRILLKKKAAAQENRMNSPFVKGTSNLERLNSMSPAARLLATKKLGVHKNVDNRLQASYSPLMTAATTPTPRRLVTPSPLTLSSSVTPKSDSITKANSNNDSDQKMNKRPKASHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNX1</accession>
    <name>A0A922HNX1_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PSMA1</name>
        <name evidence="9" type="ORF">DERF_013154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNX1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000063">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9497150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="284" mass="32016" checksum="3D8A702A95F29849" modified="2023-02-22" version="1">MFRNQYDNDVTTWSPQGRLHQVEYAMEAVKQGSTAIGLKNRDTFAVLVVLKRTSHELSSYQKKLVQVDDHIGVAIAGLTADGRILTRYMRNECLNEQFTHGQPLLLNRLMADMGLKMQTCTQRYDRRPYGVGLIVAGYDKTGPHIYQTCPSANYFDCKSMAIGSRSQSARTYLEKHLDKIIDCSRDELARHGLLALRECLPNDTQLTTQNVSIGIVGKDFPFRIFEDDDVEQFLSRLTDAEKRGRSTQSQPPAVPARDSMDVDDAQQPPRPADPTVEQRPPGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP00</accession>
    <name>A0A922HP00_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable imidazolonepropionase</fullName>
            <ecNumber evidence="5">3.5.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">AMDHD1</name>
        <name evidence="13" type="ORF">DERF_012125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="5"/>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP00"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000007">
        <property type="entry name" value="Imidazolonepropionase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752:SF1">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="326"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9501267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="439" mass="48939" checksum="D3EA1E97FF52C407" modified="2023-02-22" version="1">MVKPKTAIINCEQIVTICSNNQPFLAGEKQDKIESIERRDHGVGVSIVFDDDGRIMAIDHHDRIDNWLCQNYGNNCWQTIDTIDGIGRSIIPGLIDSHSHPIWAGDRIDEFDRKLRGATYMEIHESGGGINHTVRETIRANESELLQSLLLRINRMISCGTTILECKTGYGLDYECERKMLRVIQQASTMTPIQLVPTFLGAHSIPSGMTADQGVEHVCKMMEKLSHDDPELKIEFFDVFCETGVYDNQQTERILRKAQQLYPESKLAFHGDELSDQNSGCLAARLDACSVSHLEYLNTAGIEAMAAKNIAGIINPTTCYLLKLRKPPVREMIANNVPIVIASDYNPNAMCYSLPMAMNLATIHLGMTMNESLIATTLNAAYALNRSNEYGSLEIGKRGNCLLLNCSDWRHLITEFGNTSSLIHNVIINGKNVSSNSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP48</accession>
    <name>A0A922HP48_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_013167</name>
        <name evidence="2" type="ORF">HUG17_6192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP48"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324678" evidence="1">
        <location>
            <begin position="22"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7643830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9497163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="303" mass="31228" checksum="0F7F9679851E4C20" modified="2023-02-22" version="1">MMCKIIVLTTFLLSIFDLTVAGGGNAGNTRGFSGFSGGGGGGQYGRMMGGFHSSGLGMGNVFHHQQIGGGVMTIDQLGAGRQESFNGLGPELAHLGTGISSAISGGIGAFMGLQGGRSSGGGGGYNAGGGGGGNSGYSGSSRGGGRINAAVFSKQTFETKPVQSQFGPIEPQIIEIEGSDLPVEIVFKSASGRIKVRQEHRMQGAGETEYNQFEEEPHRLVTEVRKPIIQEVREIISPQRKVYQEIEPVIEEIHTIVAEGQGGRGSGGNYGGSNGGGNYGNSGGFMTQQRTTEYAAAKAKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP95</accession>
    <name>A0A922HP95_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP95"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9493775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="74" mass="7988" checksum="0CA7B03A9A1678F1" modified="2023-02-22" version="1">MANDDKTINFIFDSGYCMMVNQEMKKKYVVIPATTTLATEKKRVHVVVFVVVDRSSSSTSASASASASASGKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HPK0</accession>
    <name>A0A922HPK0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_013458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HPK0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9497465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="75" mass="9165" checksum="CB33BA11BFED3EE0" modified="2023-02-22" version="1">MNEQQQQKENFFKFNVDVQMIREYMAIITMMIKPVDYQFLLKKTVFKPDDHNNDVRGLSDFITFLIDYYYGFGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ17</accession>
    <name>A0A922HQ17_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_013668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000038">
        <property type="entry name" value="Myosin-M heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF5">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="1172"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1640"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="413"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="653"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="690"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="735"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="806"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1565"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1696"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="756"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="841"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="879"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1022"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1064"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1579"/>
            <end position="1595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9497705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1725" mass="192044" checksum="1203E2782DFCD663" modified="2023-02-22" version="1">MEKKLNQLTTTTTTTNIQSLRLHGNPMVIDQNAAAYLAYNHHHHFNTVRAARLKSIHGHQNQHLHSMIQRQQPPASSSSTLNGLFTWKRKLKTNKTIGNNGTGTVSGDRTLIARHTNYRHAQHVVSTVPNTSSSRSMATVPPSLARLFVRDAGSPQRSSSSSHPSDSMCVCRGLTGSTFMAPSYFDDDDSQLIAPSKGKHSSVLSMSNDSLLVANSNQQLTNTKHHPTSVAMGKHFHTINERRLTNASKSLDRIASQSSVSQNKQSNQSINQSIGHSGSNNRRSILECNVNPYELVMTNGSNHEPDVSSTAKLSKRNKPKWKSTTVTVKSSHPMWANHTINNNHKTTNMFDACLDCKDKKSTNRLIRNLFSKANSIRIAGQTVYSAIQFADCPHRQLSGLFDQETNLQHLLPTNPLHRTRSSGSLSSSWSFDSNSQSNSDSSLNRTSNASRQRHDVDQRILTLIDEPEPDYDVEDNNSHVCHVEHTDQQLKNSNDIKVDLPRKKSPTNSIKRPKNTPPPPPPPPPPELFSTPLPKLTNCPPSKNESENQQSNIKSSKSNSQEGKSYQNELKERLNQGVKSILKKTNFYSQHSSSLNEMVLAVAVDDNSETDDVSFKEKKHVHFRMKRTSPSSTVGSVGLNRSRSASHIITETIHEEDDEHGGYYDDVSHSPDIDDLPLLTTRSVDDMTDFGEKNSTDFANGCTEPLDSSSSIQNQDEDIIDETGNESLLLAGKENNHSSLPETNSPSPPPVPARRYQQSNDDGNGKSTPAKLSTIMNSPKFHSTGSVRSLLAKKWNFSNSTAATIKRSPNHSLGRRLNFSNLSTNQHDDSLSDSQNDDPKSITSSMKSTDSGCSSLFETSTSRDDDDLTEITESNPIIKSEDQGNCRSERSVNRKSEVDDHIYEELDYCYIDSKAINNASIAKNDNKTKRLFMGTRDEILDYLNGARQRFDVDDNNKLDFDSDHIGSSTSTNNQITAEDIESGYLGNDDSGNSSLCMADDYQESLVYFIKKKSSINPDLSPVVGSSSARRNRVSNISNSSSESSATSGVSVSNLAMDDMDDDGITTSSSSLGSSANSSGYYVVANRIGPTVERNDSGVGHEIGCRTTATKTIYDTAPGVDDDKKDHRICLDCERPSETGTNRSPMTNSNGSAPHYYHTFSYVCNTCQKRRNERKEIISEIVDTELKYGRDLRIILEEFAKPISVAGLLTQQQVDDIFLNLDELIDLNCQLAQILQDAVDVAIEQGDEVKFMSLSFSLPSLMIDSYQQDLTTVNIGHLFNECLLDKIAVFERYCIRQASASLLLNQLEKEKELLRIFLRVSQMENALLRRMNLRSFLVVPVQRVTKYPLLLNRLVKVTPCHYADCDSLRETQMKFEIHLDNINQKTKGSIAATTSRIWRRISNLSSTSMRIRSNDANHNVIEDFGHVKLKKTSLELLKWPQDESRFVLIGRLSFIVERSGTAANSEQLNASCNTGLTIINGCSSPHATVHNSLSNSSTSSSKIWSRTLKFSTAHAVLIVRSSPNPGSEPETLNVETSINQTLLDVAINHSNGDCFDGNDSLRFNSTARRRSSSKSPMRVSGSNSLSLSQQCPSKSKTNSDREAMLILFKEKNGRYTLCRDALNLAMCVIAKATDFDNEGYFEIHELESRESLLLKAETQSEMREWLEQLRTQSQCLGQWRRRRNALPNIMVLRNMDTDMNHNSDEDDNTSLNHSQHERFPSNTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQ94</accession>
    <name>A0A922HQ94_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HQ94"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="65" mass="7076" checksum="3667C5BA024A8CE5" modified="2023-02-22" version="1">MGGFNIDGDGDDNGFGMEFMISDDVDDDDDDDSFDLSLIDDIGFDSTLNTNMNGSRSSNEKTKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRG0</accession>
    <name>A0A922HRG0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9505980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRG0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037646906" evidence="1">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9505980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="247" mass="27861" checksum="61642B9B473EFE25" modified="2023-02-22" version="1">MFKIISIGLMALSLAMIQARSYRSFGTTNKIPFTNGYQRSAAAAALASPIRSGSRIGYSIVGLGQSNYIRPSSAAYRPSSLYSNEPGAALAIRTTHRMVYYDVPNERNYQQQQSSSPIYVDSQPIPITLMMRTYSSPINIQHSHYQGQGGLEETASEDQELRFIHTITKPVVQEVREIISPIRMIYREIQPIDERVETMIARRKNSDDNTIELISLDKGSSLDLSSLFPKYPDNDNKKKQRRASLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRI4</accession>
    <name>A0A922HRI4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">DERF_011069</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRI4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9506331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="161" mass="18730" checksum="CC96C0002146F42B" modified="2023-02-22" version="1">MISIIRSKFSSVQSFILGIYIHPLTNSNSRITANNSSFHRWLSSSSQEFDEKTYEKLANKTLDDLNDRFEQFLDQIDDKNCDITFNNGVLTISLGTNGVYVMNTQTPNRQIWLSSPISGPKRYDYIDGKWIYRHDGKSIQELLQNEMEQLFKDSYQKLKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HRI5</accession>
    <name>A0A922HRI5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">DERF_012119</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">Derf</strain>
            <tissue evidence="15">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HRI5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="187"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="406"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="733"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KAH9501261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1221" mass="144176" checksum="614CDF0ED6411670" modified="2023-02-22" version="1">MIQSKCQFSFCHYYLLTKSIIHLSFWLLLSPSSIKYNDCRLNKHTTADFWQQFHTTLVNIGNFPSVSTSLSKNETILHLNGSKNNDDDDDDNRIQSNQINENCNNLDHHHNQFPGITSSSGNNHQRRRRRQKRHNSIRNNTAISKPWTTIPDRVYCGIVKKLSNQTTLNGVVRPSYYYHRLNEIVTPKRYRLRLRFDFEQKKLFGHLTIQIRIHNKTNQIEMNGRGLKILKATFSTGSIQINTNMIYYCPTTETIVLHFPKQLHRGGANITINYSGNLTNLIREQIIRQSYREYQQISWIDFGPIDARHMIPCWDEPRYKATFDLYLIIPKNTMAISNMNIDRRRSYSHYLDEIHFNTTPLISTYQMTIMMAPKFEITNSEKNHTKVRVRLITTATDSNDSNQWQFALESTEHLLEYFQYYYGHKYPSDKLDLITLESNQGQQTSMEKFGLIYFTHQDLSIKNLTLIGERDLQTVVSMLAHSISHQWLGNMVTFDDWSEFWLFEGLNQFMEKQAMDDVFPQWRSWQQYTADEMSLALRLDSSLNAESIQNSIRNPIEVSMMYPQGVNIYRKTTFLLRMLKQNLDHDIFRLALQKFINKYWTKTGSLKDLPECFLMAIDGIDQKDEKKYHQYRQFQKQIVRIFSNWTEMAGFPVLHVDEQRQNGNTRILLIHQERFVELRQNLSTTKVVWQQKSLWPIPISIVKSFNPFTPTNQALIENERVELRIPGIWSGEWIKLNPVFSNFYRIHYSDEMLNRFIVPIEEKLLPPLDRLNLIDDVFAMIRAGYTSTVTGLKLLQSFENEDNPNIWSVIITMLTDLHLIISNIESDHYRQSIQSNFEYYAQRLLKRMYHRYNNNWYSSVNQRPVGYRMKINQFARNQLRTRILCAMGQFGYENFHHEARIKYESYMENKIRSDLPLEILECVFRSFNSFRLSIDGARAAKTMTSKLQFEDLFKHYNEYDNETKQPEAKHLLSIALGSTNRFEEIRQVIQFALKSSNDDDDDDDVNDYDSRLMLIELARHSHIGRQQVLETIIMDNHYLDFITNKFQTLNQLYEFFRDLIETFTIRSELQPLEQLMANHTRLFDPIKQTLKLSLEKVQIMEQWYRNDIDSIRIFLEQMAEKSSRHDTNGDDNDHNNNNNHAMSMDNIHQPSMIDFSDLSNVNHNDNIDIDIGFDDDDVDVDGRNIVDDNNQLLPSTTAATNNSVIVNDLFDDDKFEGFDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUD2</accession>
    <name>A0A922HUD2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transducin-like enhancer protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TLE1</name>
        <name evidence="9" type="ORF">DERF_011146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUD2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000001">
        <property type="entry name" value="transducin-like enhancer protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005617">
        <property type="entry name" value="Groucho/TLE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF21">
        <property type="entry name" value="PROTEIN GROUCHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03920">
        <property type="entry name" value="TLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01850">
        <property type="entry name" value="GROUCHOFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Groucho/TLE N-terminal Q-rich" evidence="8">
        <location>
            <begin position="9"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="703"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="785"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="227"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="272"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="502"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9506412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="861" mass="92099" checksum="664D24056DEC8409" modified="2023-02-22" version="1" fragment="single">VPQAGQTTFKYTILETCERIKEEFNYLQAQNHSLKMEIEKMAQEKTEMQRHYVMYYEMSYGLNVEMHKQTEIAKRLNTIIVQIMPYLSQEHQTQVATAVERAKQVTMSELGTILSQQSGIAHLLQLEQIRSQQQQQQQQGIPAAAAAASHPNGPGSSSLTSNAITGIGPTSLAQHAAALHSGLPAGSTTAAAAAAVLSAAGIAAPSNSATAGLLALSTGSLNPNGIQSITGTTPTSSTTSGLLPGSLMTSLSSSSNGLNPCSTIPLPPPSSCTPNSTTSSSSLQATNNNNNNNASIKQESIGGSSIRDISDRKINDDNRREDQISPHNGDTLSPRETTLATTTTTNSLPEIRSIKRDRPSSRSSSSNRSTPSGHHKTTTSKNDHGDSKSPTSLNQKSGTPNHNHHNNNNNGTAANNNNSITNGSKTPKPTTSIGPPYPYLPGPPGMMPSDISMAAAAAAAAYSQGLFNNNFGVTTTTTTGSLITGFPRTLLPGTVFDSSTHPSMMKGQQMQQQSSMPGQPIQPQSSISSGGKPAYSYHVDADGQYNPVPFPPDALIGHGIPRHARQMNTLPHGEVVCAVTISNPTKYILTGGKGCVKMWDIINQQQNSKTPVAQLDCLQRENYIRSCKLLPDGRTLIVGGEATTICIWDLNLPTPKIKGELSSSAPACYALAISQDSKFCYSCCSDGNIAVWDLHNQTLVRHFEGHTDGASCIDISPDGQKLISGGLDSTVRTWDLRENRQLNQYDFNSQIFSLGYCPTGEWLAVGMESSNVEVLNVNKAEKYQLHLHESCVLSLKFASCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADNKYIVTGSGDKKASVYEVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUI0</accession>
    <name>A0A922HUI0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Synaptotagmin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SYT2</name>
        <name evidence="14" type="ORF">DERF_011204</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptotagmin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUI0"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08385">
        <property type="entry name" value="C2A_Synaptotagmin-1-5-6-9-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08402">
        <property type="entry name" value="C2B_Synaptotagmin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000007">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000016">
        <property type="entry name" value="Synaptotagmin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF227">
        <property type="entry name" value="SYNAPTOTAGMIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="230"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="363"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9506474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="509" mass="57526" checksum="1EEE7D6C0A2F503C" modified="2023-02-22" version="1">MPPYQLLNPHFSNELLFKRLLSRQIRSSVDHHNDNVAKAANNGGELEFVPGIEFHKPTVELARQLGDINGTTGGGGGAESYSRGQDETVNDFTTTVRSVINSTIKNMAKGTKVESMKESTSFFDEVEKPVENMVKTVAKKTSLPFWVVFLIFLVIMGILAMVFFCCLQRWWRKFRGKEAKGGFMGGKVDLKSVQLLGQTYKEKVQPEMEELTKDMEQNEAGKDDAKEEVKLGRLQFKIDYDFNQSNLAVTVLQAEELPGLDMSGTSDPYVKVYLLPDKKKKFETKVHRKTLNPVFNETFNFKVPYAEITTKTLVFAVYDFDRFSKHDQIGEVKIPLNQIDLAQTIEEWRDLTSVEDAQGQENKLGDICFSLRYVPTAGKLTVVVLEAKNLKKMDVGGLSDPYVKIALMQNGKRLKKKKTSIKKCTLNPYYNESFTFEIPFEQIQKVQLVVTVVDYDRIGTSEPIGKVVLGCNASGTELRHWMDMLASPRRPIAQWHSLKDPDDGGGKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUQ6</accession>
    <name>A0A922HUQ6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_012721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000313" key="2">
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    <evidence type="ECO:0000313" key="3">
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    <sequence length="2070" mass="240768" checksum="9836BE70626709CC" modified="2023-02-22" version="1">MKPSNTDKIELVEEDKPEEITESIEEIETPEGKKTVLKKVKKSKIKVEEEEEMKPEEKTKPKKLKKLKPKTEDDEKAITEEMIDLKPTDEILEEQAPEEEIQPDIESEVEVETKKKLVKKLTKPKEPTADLQEEPEQKEITEETTVTVTEEIIELPDEEGEKPKDETKPDEEKPKKKKVIRRKSKPDGLETKPDEETKIIAEKLIALKPTDEILEEQAPEEEIQPDIESEVGVETKKKLVKKLTKTKEPTADLHEADEKEITEETTVTVTEEIIELPDEEVETKPDKDEEKPKKKKKVKKQITEQVIEVIEIYEVVESIPAIEQVDGQKKKIRKIKKIKKSEDQQPIEYKEEPEDQIILDSEDKPEKVIRKVKKDKKPKEEPDEEVIPEQPSEKEITETTETIETVQEIDTPEGKKKIVKKVKKTRKTDETTPITDKIELVEEEDKQEEITETIEEIETPDGKKTVLKKVKKYKKPKEKPLDEESKISIDYEKLIEENKPIIEKITEQIVESGMIEATKVTETIEMSPEGEKKVVKKIKKVKKPKSEKPEEIKPGTDEIKTTEEKPTQEITDQPSEPELIETIETIEMTPEGEKKILKKIKKIKKSKEQPLDEESKPEIGYEKSIEEDKPIIEDIEQPVESEIIETTEVIETIEETPEGDKKIIKKIKKVKKPKITEEISLKHDQQQPIDEESLEEEIRPKDQSETKRKILKKPKQKESITEVQETGDKEVIEEIKTDFFEEIIELPKDEEQKPETIETTPEGDKKIVKKIKKTKKLKEEKPEEMKPEIKDTKPTEEEKPIQEDRTEQQPKEKEMIETTEVIETIEMTPDGEKKVVKKIKKTKKAKEEKSEDEKPDEKEKAKLEKIIEPGKPEMIETTEIIEADEETPEGDKKIKKVKKLKIEEIKPTEDEKPIIKEMTEKHDESDMVESTEIIETIIEDTSDDKKVVKKTKKIKKPTKTTSDEELVELIDIYEVVESIPAIEQVDGKKKKVHKIKKIKKPEAIKPIEYKEEPEDQVILDSEDKPEKVIRKIKKDKKPKPGDELIPEQPTDTPETTEIIETVQEIYTPEGKKKVVKKTKKTEDTKPTEDEKSVEKEDEPEVVETIEEIETPEGKKTVLKKVKKSKKPKEEKPIQEEITEQPEETEMIETTEVIETIEETPVGEKKIIKKPKEQPLDEKSKPEIDYEKPIEKEEPTPELIETTEVIETIEETPDGERKIVKKIKKAKKPKVTEETVSLKPTDEPIMEESLEDEIRPQDESKIESDTKRKILKKSKRKESISEIPETNEKQVTEEIKTEIFEEIIELPEDEGQKAEVVETTPEDEKKVVKKVKKLKKSDDKKQEEIKPDEDISKTETTESEPIPEHIDEKLKIFDETDIIEEIETTTEPDGKKKATRPKTKKPKHSEEETISEEKLDEPIEPKEHDDMVETIEMIEIYDVVEFTPDIEIIDDSKQKKVQKIKKIKNLKHKEPIDYEEEPEDQVILDAEDKPEKVIRKMKKDKKPKDQRIESEEILDEPKTEEIIETVVEIVTPEGKKKVVKKLKKIEKTDEMKPKEEEEKLEESTEMIEEIETPEGKQTILKKVKKIKKIKKEKPSEEQTKPEIEEEKLIPENIVEEQPDEPEVIETTEAIETIEDTPEGEKKIVKKVKKVKKPKVIEEMIGLKPSDEPTIEEIPEEKIPKSKPDEQSIIELIEIYEVMELTSDVKNVEGKKKKVHKIKKIKKPEDQQPIEYKEEPEDQIILDQYDKPEKVIRKVKKDIKPKEEPDEEVTPEQPSESETTEIIETVQEIDTPEGKKKVVKKVKKTKKIEEIQAKTDEKPIDKTDEVMESIEEIETPEGKKTVLKKVKKSKKPKEEKPFDQKLKPEIEFEKSIMQDEPKMEESVEQPGEEKMIETTEETPDEGQKIVKKIKKVKKTKASEETISLKPSEEPLTEEVPEEEIRLEDESKIDTETKKKIIKKPKQKESITEIPETSDKEVIEEIKTEVFEEIIELPRDDEEKPKGIIESIEITPEGDKKIVKKIKKTKKPKEEKPEEMKPEIKDTKPTEEEVTEQPVETEMIETTKNSRDDRNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HUY2</accession>
    <name>A0A922HUY2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TXNDC17</name>
        <name evidence="4" type="ORF">DERF_011195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HUY2"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="37"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9506465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="171" mass="19182" checksum="D9A9F79F67AF8F7E" modified="2023-02-22" version="1">MISIQLMQNLKRHFFSFKNSFILQTKRMKQISIDDSQKLDNLIKENEDKKLILLFTGTKKANGKSWCPDCVVADPIIESVVKETTEDQNMIFATVMVGDLPSWKSSDNGFRKHPKFAINCVPTLVNVPLNIRLEEGGCADKTLVKKLFEGTLETGVTSKAGTCVDGVCRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HV98</accession>
    <name>A0A922HV98_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PSMD13_1</name>
        <name evidence="3" type="ORF">DERF_009580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HV98"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSD13 N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9511109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="227" mass="26415" checksum="19BF42879EC76311" modified="2023-02-22" version="1">MSQKVSNFLTKQQQSSNASYWVTFDELYNKKLWHQLTIKLLEFIHKEQPRNLVEIYENFISDFETRIKCLSLVEIAVFIVKEISNHEEKLQFLEKIKEKVKNDSLAVILCEILSGQIKLEVNDFKGAKEIIENIDQKIDNEYGITTVHARFFQLASDYYQKIGDHAEYYRNALRYLGCCSTAGIEIQENDEILAQRAFTLSLAAILGQDIFNFGELLLHPILKKLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWA7</accession>
    <name>A0A922HWA7_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U11/U12 small nuclear ribonucleoprotein 35 kDa protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">U1 snRNP-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SNRNP35</name>
        <name evidence="9" type="ORF">DERF_010517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9512117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWA7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000132">
        <property type="entry name" value="Small nuclear ribonucleoprotein U11/U12 subunit 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF6">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 35 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="312"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9512117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="422" mass="47449" checksum="1AF772EC80C00ADB" modified="2023-02-22" version="1">MSYRGERKRRHSSSDHGDDLSSHAPPPPPSSSLLPQRSGGISSSPSSSPEWNRSTSNGGSGGGNHHRRNHHLSSPNDDRIGGGSLSHGHPHHHHHHHHHHHQQQQQQRHRSPSPRSPRSPPPSLSSSKVPPLSSSSSRRARSSSYDPIKVGYPSKQRQRSTSPPFPSSHRHYDNHDNRPHDRALVRAMNSDLRPAKDHRSDPEKTLFIGRLNGTTDENTIRMHFERFGDIRSLFLIRDVLTGDSRRYAFIEFRRAKDADRAYAEGHNTLLDGRRILVDRELGRTEKNWKPRRFGGGFGGQKESGQMRFGGRSTIEHRGFNNNNNSNDHRSGNDRTFRTPLHHRSIAAPYPQQSSSFTSRRTNGIDRYNRYDHPLGAPMHSSSTRSYSNGHTSSSSSSYRHHSTSDHHSGGGGGPIRSNTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWK5</accession>
    <name>A0A922HWK5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_011688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWK5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="69" mass="8028" checksum="332C6EDB34F4CE60" modified="2023-02-22" version="1">MQITTTTTTYLRDGEFFFLASGFIEHLSNGKRMLTMPSACSKNHDEFEQRSNRISYQITKQQQQPPLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWN3</accession>
    <name>A0A922HWN3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_009138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWN3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9510619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="136" mass="16319" checksum="7F3CFEA22C11C6FF" modified="2023-02-22" version="1">MHNYTNYNNYTNKNYTNYKQLHQHHHHHHHKHHHDHDEDKNHKHHRRGQEPQTPPRPRRGQEPQTPPRRGQEPQTPPRPRRGQEPLSPPRRGQEPLSPPRPRRGQEPQTPPRPRRGQEPLSPPRLLKKYRSIGGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HWV1</accession>
    <name>A0A922HWV1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HWV1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="6985" checksum="9D860DBFCA8FD45D" modified="2023-02-22" version="1">MFNLNWTQSSIPNFIDCWLRLCANFSSCSFLQLPIMTNSGLSVDPFSRKMSINLDIDFNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXQ9</accession>
    <name>A0A922HXQ9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GSTK1_3</name>
        <name evidence="4" type="ORF">DERF_009645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXQ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="3">
        <location>
            <begin position="4"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9511174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="221" mass="25350" checksum="98747FD613047229" modified="2023-02-22" version="1">MTIVEFFFDIRSPFSRIQYELLIRQQNHWKSMTQLRMTPVLIRNIFEASGNLSPAMNPAKLAYLTRDLVMLADYYKMKYATPKEFRKIVTESPMANTQLFLAAIQNHSDEATFNRLVGVIFDGFYQESPQQVWQVDVLRQLAMKEGIASDVVEKAINAMESDENRAQLEKNTKRPIELGGFGLPITLVHSDNNNASWVFGSDRMHIIGHLLGEKEPPILRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXX3</accession>
    <name>A0A922HXX3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_010095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXX3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="89" mass="10631" checksum="DC2390783A955970" modified="2023-02-22" version="1">MKKKEKKKIGSQNFHRFSLVYSGSFDLVGFFSVCRYTVLRYFRFLTPLHNHHHHHLFVFKDSFGHLVARNKEKNNLIDRYISASKCIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXZ7</accession>
    <name>A0A922HXZ7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXZ7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="100" mass="11301" checksum="89515DCC0CBF10F2" modified="2023-02-22" version="1">MKRNVSATMVATNRFEQQLHHHQQSHEQMKLFQCSGNDVHHPHHHHRRSHEHHTSIGMVDSAVAATMAPQLPPHPPSSTTSTSSVNKRNKSKIPLLRNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HXZ9</accession>
    <name>A0A922HXZ9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_010130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HXZ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9511691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="84" mass="10253" checksum="F5D33A8C6C52B1C7" modified="2023-02-22" version="1">MKLSLVSTKYMDYLVLYYYLIFDLTKLIYSVKESRTFLHIHFCSLLDRVSHIVIIPNCHHCPIYYFENNFQHITYCCDKMKNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HZ39</accession>
    <name>A0A922HZ39_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HZ39"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="452" mass="53211" checksum="8D9B08B38CC58429" modified="2023-02-22" version="1">MRLDTAVRIVNYPITKMLLKNNIGYIDKLKKSRLKILLQKSSISDDDQQQQQQQDQQQQQRPYQRFCNLQFWLQSFIFLFWLIRGIVILLISDGSVSATILGSVFNLLKIVRIYPELVAFHFAIKDFLCHLIIYGRYKRFRFYQCIIAYCHQIYNPYLNDEQNNLIKQSYIDTIRLYLDEKKLTEICLFIKERFHGHCHIVCGTTVIIGITGCLVFFAINPIDNNFHLFGHSYMLYGLYNLFYPGFCSIWSYYGFMWTSNLLTYFCIVCQILKAKSIQNEKQMKNFKKFSSSKIRSHLLAQSDLFDEIRTMNEFWRSYLSITITVYIILSCLSLYIVALTNVLLSMKIFFIAIFIQPIAIILLLTLTSANLCFKIFQLHKRYYTMLASLHSVRHVNRWKFKLMSSLEIINSKTTGFTLNNQVMIDYKAIGMVIANTTTLFILVAQNLKNNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1A6</accession>
    <name>A0A922I1A6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1A6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="8235" checksum="7B675C7866A04239" modified="2023-02-22" version="1">MIFITPPFNERKIITDLDAVKKNAHLHNTHQHYNLYIPGVCKKKPWKKTQKRKRKRRKKEMKTDHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1E9</accession>
    <name>A0A922I1E9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Chitin binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Cpap3-d1</name>
        <name evidence="9" type="ORF">DERF_007945</name>
        <name evidence="8" type="ORF">HUG17_2238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7646700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1E9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.140.10">
        <property type="entry name" value="Chitin binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002557">
        <property type="entry name" value="Chitin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036508">
        <property type="entry name" value="Chitin-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051940">
        <property type="entry name" value="Chitin_bind-dev_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301">
        <property type="entry name" value="CHITIN BINDING PERITROPHIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23301:SF0">
        <property type="entry name" value="CHITIN-BINDING TYPE-2 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01607">
        <property type="entry name" value="CBM_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00494">
        <property type="entry name" value="ChtBD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57625">
        <property type="entry name" value="Invertebrate chitin-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50940">
        <property type="entry name" value="CHIT_BIND_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5038324713" evidence="6">
        <location>
            <begin position="21"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-2" evidence="7">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7646700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9517267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="234" mass="26434" checksum="EF46D563CEAEDAD8" modified="2023-02-22" version="1">MIIIGLSAILSSLIIVLVNAADSGLEEIPLHCPPDGVFGYPHPKSCDEYFQCTNGTMSHEFCPNGLLFSHTGHVVGMCAYYWNVDCGDKTIPKPMSTPGCPYQFGFFAEDNRQPCNVFYSECAWGIPQRKQCEPYGLFYDERIKGCNWPDQVGCSSESLLQFKCPDDDHSNKFWPYPRYWYNQQAIITCVSGQPRLIQCGENSLVDGNSLTCVEQHKPENEKPLRTTTNHGRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1T3</accession>
    <name>A0A922I1T3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1T3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037691150" evidence="1">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="245" mass="24000" checksum="1B908179626C8394" modified="2023-02-22" version="1">MMFRIIVATLMVAGLASAQMGGRRVFMRAANETNDGKDADMRNYGGAYAPAPVYAAPAAPAYAPPPPPAYAPPPPPAAYAPPPPPPAYAPAVAAPAYAPPAAPAYAPPAAPAYAPPAAPAYDPGICICTSPAPADYAAPPPPPAYAPPPPPPAYAPPPAAPAYAPAAAPAYAPPPPPPAYAPPPPPPAYAPPPPPAPAYAPAAAPAYAPPPPPPPPAYAAPAAPAYAPALPPPPPPAYAAPAAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1U7</accession>
    <name>A0A922I1U7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_007700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1U7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9516998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="93" mass="11136" checksum="CF84B8DB592D699C" modified="2023-02-22" version="1">MDAVDSIEAHLQRDKLRLEKISLKLDSNLYRCGKKIELQYGQQCALDNIDQIPRKLNEMYDRLESLKAKRDEFIQENHTKLEQLEKRSEKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I1X0</accession>
    <name>A0A922I1X0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Early endosome antigen 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EEA1</name>
        <name evidence="9" type="ORF">DERF_004420</name>
        <name evidence="8" type="ORF">HUG17_0531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I1X0"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15730">
        <property type="entry name" value="FYVE_EEA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.390">
        <property type="entry name" value="L1 transposable element, trimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69979">
        <property type="entry name" value="Eea1 homodimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="845"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="190"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="518"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="651"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="711"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7644993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9520729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="896" mass="105244" checksum="A569D827336FE576" modified="2023-02-22" version="1">MAKNTNKLKSLFSGINRTGEQLINSVLNNTNSSINSSESDLINPSLDEKERSLSIASSINGNEMLSTSSSSLATEAEGFLCPQCFAAFPNAEILTEHFSSEHSTFGDQNLSFVNCNHCRMRFTNEYELNQHVDKYHKEKSQKSDEPLIAQLDQSTTKQLTDSFSQVLKSAFNSTNNRQQDMEKMFTMEEFDLLQRQQKALEETKDLLLNELSLLRDSLAKKDEQINRLDRDFQQEKQLLVTQLNEAFQREKTVLENLNTYKDRTANKDDEMNRLRNENENLRTEQQRYKDQLKKITDEKMQQEKLCQKLQNECDSNRKILLDMTSKTSDSLSVMTNEKTELMNKLQQLQLEMDSIKKQNEDSERHIKCLQIKNSDSSEYGKQLEKIEQLRKEELNDHRNTIKQLKSDKLKYQNICRTRIETVRSLLRAEQNTTKQMRTILEQTHKYIDNANQQINQFVHDESKRNNELMEWKNQQIHLLIKEKDEISLKIQHLEGKNCQLNEKNYQLESQINHNEQEQLKLNEKYQKVLEKLKKSQQQTNEHEQMIHTLMDTKSTLEMNVEELKSMMNKQRDEYQQKSDNQIQSLKKISSDMQKIRYAVQDKCLTIKSSLNWLQNSCKDLSENLKDITIPEMKTSVELLENDFTILFVTIKNHYSDKIDALTKQLESLKSENHEITKIILPNKQNELEKMIKSQSSLKSLVESTKNDLFALRTKEQENQKLIERLQQTKQSLLAEIEKERARFDNVQKYHDQVLGEKLKLEIELSTFMEEKRALLERCATAEEQLEATIVEMKQIVKKYEENSKAVQELGEQNQTLQIRLDEANNKLRRSWTDDRMVDKCQNDKCQKLFTTVIRKHHCRSCGNIFCNECSSKQAQMTGHPKPVRVCDHCYQELNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I243</accession>
    <name>A0A922I243_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I243"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="114" mass="12332" checksum="1291393DA42962E8" modified="2023-02-22" version="1">MNFVKKKHHKTLETPYCVHINIAVIVTVFLVLELRLKYQTAAAAVAVAVVSVKIPTKTNKVTKSFLSLTSSFLQSDGQSVIIIGAMCIHFIFELIGVGYGIGGDGVEKTTTAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I2Y2</accession>
    <name>A0A922I2Y2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I2Y2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="434" mass="51250" checksum="FEFBD329D7D17173" modified="2023-02-22" version="1">MKNIHFECCNRSEESGRIHHLGIQLKPIDYRNRKCLIQVMVNILINVIGILYYNQKAVSFWDYDAIKNSQKTAKSLNNFMSLFGNNYIHVFLIINPIVFYCIGPSLNRLMALSPFKNIYRSRKKSIHVLAIMLSTITVNFVGFTIFDGSQNLKKNHTLRTIIFEFFINYYISVSYFIPGLALNYVKFATIEMLKAISATRSERKNIETIIKEIGEMATLNRKISSILSPMFSIFLISTMFDMIVLFMWFSNMGWDFIRIFFASLTTWFYIAYLVRLDNQIIQIFEKISTNLLENNLFECCGHCCNNNRMVEYGYINKKIYFCKQKQRIIECYRLYEEDFRMNIYDFCPVDYQLILDSFLFISEEKNVKTIIKKIGEMATLNRKISTLLSPMFLIFLFSSSLDMIVLFMWFTDDYQFILDSFLFILIFVVISLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I3Z9</accession>
    <name>A0A922I3Z9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I3Z9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037449864" evidence="2">
        <location>
            <begin position="23"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="744" mass="83726" checksum="FC5CF9A5E2E52DEA" modified="2023-02-22" version="1">MFSKKFGCLLAIVFIVVGNVYALLEVPVPVFGQSNLQPPEPGQRNFNGQSNPPEPGRRNFNGGNNYGSPSTDVVLPPNQYRKPDVGSPRTDVVLPNQGTSFVDSMQGDDPVALAQSSFQPPEPGRRNFNGGNNYGSPSTDVVLPPNQYRKPDLGSPRTDVVLPSNQYRKPDLGSPRTDVVLPNQGTSFLDSMQGDDPVVLAQSSFQPPEPGQRYFSGGNNYGSPRTDIVVPSNDQYRRPDLNSPRTDIVVPSNDQYRRPDLNSPRNDYVVPSNDQYRRPDLNSPRTDIVVPSNDQYRRPDLNSPRTDIVLPSNDQYRRPELNSPRNDYVVPSNDQYRRPDLNSPRTDGILPPNNQYRRPELGSPRTDVVVPSNQYNRRARSPVLDMMQGDDPNPIEPGQSNYYRQGDFSKPLEPGQPSLRPYGQSNVIDGVVVVPPAPNNQNNPFNTPRTDRVIPPNYDPNYDRPFDSPSTNPILPPNNPRPFDSPSTNPILPPNKPRPFDSPSTDPIRVVSYPGGLNSPSTDVVVPSLYPTNGPSNPPEPGRTNYFDHNRPHWSCDMTREDQCRLENRANFVQFKRGIAFNSPALVLDVTEAIRTRQSLPRLNPVKSYNAGRLVTRDYFPANNRVACLHFSYAWSGNEDKRMHLIQRNREDKCIFSAHTGSINDRNGEWRDVELQLDLSQGDSAFLIEFSFDIPNRENRYRRQTRIYPIDRINGGDSIIAVRDFKIGYGYCRNNQAFECDLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I435</accession>
    <name>A0A922I435_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">DERF_008276</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I435"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08554">
        <property type="entry name" value="Cyt_b561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF0">
        <property type="entry name" value="LD36721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="515"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="715"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="721"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9517621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="790" mass="88309" checksum="4F2A3782813BF7D0" modified="2023-02-22" version="1">MDVEHELSSSIHKKESIIKIPIITPLSSSSSSSASKMSETFDEPTTIRSLTSDTCEIKTSTTQQQQQQPVAKVATKFKIKYKSLPRTTTITTTKQLEPLLSSKLGFGIPRSNSISFEKTSDETESKSIAETLSITLKPENTINNNKTIQVKSKQTFPEQEMIKFERKPPPPPPLAIIKAAPVVLTKKSPLRPPPPPPPSPSISSKSGGGEKSSIIRRVSSKSKRKSLSSSLKPKRQSSGERRLLKTSSASKKSLKNSTIKINNNTVVPTTATIQQRPKSSSTNKPRSKPSLKSKSKSIKRLTHSMKNMNESLKSVSIKRTNSRRSSLKKQNLNLNNDKTTAAAPPMMMVVKEQQSGPKPALPPPIMSVEKEELIIVRQPSKLSPTTSPLLLEKSSITETMKSDPTAAQTFTTNDDDSTTARSSTSHNDRVTVIREVHKNISGEPVVEKVKAKIVTSTGSKLSDNIAIEKESLIHNCIIYILSQILASILLVLFCSLIIQHFGGFPYEILEHSLNYHPLFMFIALVMVTSRQLTNICRLPLLIGTLVLQLTGTFITIYWHAKKEKSHMQSMHSWFGLMTIILFLTYLAGNIYLYSRHEPKKENERQKFLNRISKSIFYVRMIGLGCLVMASITCLLGLNQFEDIFNGIPSDLEHSTTGNPSSPRLLTNIASIFLIIYVGFMAYLIARQRYRSSETIEFEKQVQMAVDNAMQQMDASGVFNNPDERSRLSLKSDDDVRSLSPEKNNRHRHHRRRRRSRSDVQDSLKSPRISVCENTQKYSTSSSLLKSITIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5C8</accession>
    <name>A0A922I5C8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Desumoylating isopeptidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DESI2</name>
        <name evidence="6" type="ORF">DERF_005281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5C8"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9521645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="308" mass="34688" checksum="FF785804D4651C9E" modified="2023-02-22" version="1">MAQQPVYLNVYDMAAINQYSSSLGIGIYHTGVEIYDSEYAYGGHPFDFSGIFEIEPKDVIALGEETFKFKKSLLIGHTDFQREDVRQIVKEMGKEFKGDKYHLLHKNCNHFSDHFLKYLCGKPLPPWINRLAYLSTCVPFLERCIPKEFLIPIALENSIRGDDNNDNDDDDDVCGYRPDGDSGGGGNDDDDDDEHILKQSTSSTTSSTSTSSSNCFSPISRSPSKSQTSSSSCQQRRQRRTNLVNNFSTTNNNDDYDDVDDGKNNHHHPSTISSSSSSTSNLLNLETIRTKNSPRLDRPNRPFSNLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5D3</accession>
    <name>A0A922I5D3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_004719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5D3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="113" mass="12535" checksum="242556C7B2BAF930" modified="2023-02-22" version="1">MAIGKRKDVSPNAELQTGSKQQNINASSSSSSETSLEKRLIYGSNSQMMQQPIPNDHSTTYNDDDMQFSPILDNRKDKRNLTTTIEKINNNCNDNNSNLSYASDTDVMSAQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5U7</accession>
    <name>A0A922I5U7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methylenetetrahydrofolate reductase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">DERF_005445</name>
        <name evidence="9" type="ORF">HUG17_3554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5U7"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="8">
        <location>
            <begin position="325"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7639521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9521818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="654" mass="75904" checksum="C27D97BA6E06DDBF" modified="2023-02-22" version="1">MLEPQNSIDENDVIVNKQKYLSLAEKIRQRSSQHAYEKYDRFFSVEFFPARTPKGALNWIRLVEQYADGDPLYCDITWHVAGNPGLDSPTSSLTMANVALNYCQLETMLHITCIGLTCEQLGKHLERAKNYGIRNILALRGDRHEDYDINDFQYAADLVRFIRHHYGQFFTVVVAGYPIPHPESRDKHHDRQCLKKKLDAGADYIITQLFFRCEDYVRFVEECHAIGITVPIIPGICAINSYESMLKFAELSAVPIPPELLRRLEPVRSDQQAVQELGIHYLTDLCRQLLATNLFPGIHFYTLNQSSIMKVIKNCGLWRKYSIIRPLPWRQACNYQRIDESIRPIFWANRPKSYIHRTRQWTEFPTTCWLVNFSMDLDPCLVNFPSYLNSNLSADAKKCLSECESIEQIYILFNHYYSLMNWSTSNHDKNNNDFVNGGKSQLSLPWIDKIDGQHIESLYRQYGQYISKGLMVTNYLPAINGQCNDYSIDSMIPWSYGHQANGYIYQKEYIEFFIHIGHLSFLQSLLLDIDHDEISFMLCNRDASIRLTNWSSSAEQFPLVITWIKFINQLRPVYIADIKTFDVWLNETYSLLDTLINETPTITTTSDMDQKNISSKVLAHVRNEFILVCLIDNRFGHSSSSSFSQIFAHLFSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I5V6</accession>
    <name>A0A922I5V6_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_006242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I5V6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9522676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="69" mass="7529" checksum="9C035A20FA287E61" modified="2023-02-22" version="1">MILHGLNTDDSAISRFISYVVGELDVDDDVDDDDCDEFVDVVDFFANIHDPFDLDDGGGCCCCCGRCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I6T2</accession>
    <name>A0A922I6T2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I6T2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="273" mass="31920" checksum="BD7010040F41C2DB" modified="2023-02-22" version="1">MHNIEIDDTMMTININDDDNDCEEDDDDDEQIKIIQQQQQQQSNPDRNNNEKNKCFNIWPSLFRRSTYLKRYKRGHSHSLEKHRSRYYSQSFGSSLNDDNLSLSSSKPISSNVPFPITDKYLTHGSPISPRVKNFNLDMKILVLSRNDNPYLSKQLERSNSLTSNNSSTVTDEQEYFAIDTPHSALHTPIFNRRNYRINNGRSSSSTGQHQHQQQQQQHRSTLSFTFGYDNHRDLEDGKNLHEQLIRSPPPNFPEKLSEFLFTENLIKNLNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I716</accession>
    <name>A0A922I716_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">28S ribosomal protein S6, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">DERF_006044</name>
        <name evidence="4" type="ORF">HUG17_3108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000007">
        <property type="protein sequence ID" value="KAH7639075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I716"/>
    <dbReference type="OrthoDB" id="268530at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7639075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9522478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="150" mass="17517" checksum="2DC2A2B838F4BD75" modified="2023-02-22" version="1">MPAYELVLLIKKLQKPELASCMKRAANFIFDNNGILRKMEYFGLQPLHFRLSSSIPNAKRFNQANFLLYHLDLPQESMKKVFEDCRYDTDIIRAYFVKKESNLPDGYHCTLNDELKPPALRPSVMSLIEEGRKKKVDYNMGDSKNVRQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I733</accession>
    <name>A0A922I733_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ethylmalonyl-CoA decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Enoyl-CoA hydratase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylmalonyl-CoA decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ECHDC1</name>
        <name evidence="14" type="ORF">DERF_000303</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">Derf</strain>
            <tissue evidence="14">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer. Also has methylmalonyl-CoA decarboxylase activity at lower level.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2</text>
            <dbReference type="Rhea" id="RHEA:59540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:85316"/>
            <dbReference type="EC" id="4.1.1.94"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:59541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(2S)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2</text>
            <dbReference type="Rhea" id="RHEA:32131"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="EC" id="4.1.1.94"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:32132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2</text>
            <dbReference type="Rhea" id="RHEA:61340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="EC" id="4.1.1.94"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:61341"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I733"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004492">
        <property type="term" value="F:methyl/ethyl malonyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF27">
        <property type="entry name" value="ETHYLMALONYL-COA DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KAH9526204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="424" mass="47099" checksum="02B8FF2DBC0AC90A" modified="2023-02-22" version="1">MQLYWKLSYGLPAKQLIDSVCGWCLRRNLQIKLVSIIINNNISQNSHHHHRPARKLLNGLHQLNRSQFVIESSIIGLHHRVCRKMSSSSSSSSNYMANVNNNMVNNSNHIHKNGHHNNKSSQLHDDSSTLDNVHIPDDVLTRLPDLSIEHIREQLRQCDPNCNGRLELNMDDSTGIATLCINSPQRKNAFSGFMMAQFSDLLDQLERWKKGQVIIVYGADNFFCSGADLKTIRQNNLSDQCGAYYISQLMHSNLTRLERLPIVSVALIEGKALGGGAEIITACDFRVAIHDARIGFVHARLGVTPGFGGGTRLIRLVGSCTALQLMLSAKLIDAKTANKIGLVQHVLEPGIRGMEALEATKQWYRNEFGSISSFASRAIKSIAATSLCNISTDKALEIEANIFCSVWGREEHMKALASNIKHNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I7N2</accession>
    <name>A0A922I7N2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transducin (Beta)-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TBL3</name>
        <name evidence="7" type="ORF">DERF_005778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I7N2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="413"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="461"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="526"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="568"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="612"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="654"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="6">
        <location>
            <begin position="707"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9522180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="847" mass="97178" checksum="8AB49D3A4D7E912B" modified="2023-02-22" version="1">MKDKKLLKEIFTVEKRFDDIFRGDRIDLDQNGRILIAPCIECLNFIDLKSGQKIYKLSANEQKSQFTIDNGDDGKEECIVTFAYNSVEQNVVIAYTSGLLRHYSLTIIIDDVDKIEINHSLQRTWKSMHIGPIARIRFDTTGTLIATGGSDGTVKLWNLMQKYCTHNLKNHVRAVIQTITFAPRFTTDSYHIFVSGDDYGIHVWNLIDSKHLCVLEGHESKVTEILFTSNHQYFISGSRDKLVIIWNWHTMQKYRTMAVYEAIEAMILVPKRKFAQTLIDDDDNNEQVLVVAGDGGLLTLWDWKNGQQLFAQKQSVLAIHQNHDKDTSSSQQYTQINQLVYHPVSEQIVAISYDKDIVFHDVSTLKPTRQLVGTNDEVLDLKFIGQANRHIAVATNSPKIKVFDLDTSSCSFLIGHNDIVLTLAVFPYDRHLMISSSKDNSIRVWKFDNNDCHRAWCIYQGTGHTHSVTSLATSLLAGNLFFLSGSEDTTLKFWKLPNTETVFDSEQLSIENINDKPTNLRSKYTQSCHEKTINSIDVAPNDQLVATGSQDRTAKLWSLPNLKLISIFRGHRKGIWSVRFSPVDQILATGSADSTIKIWSIGTEQQTCLKTFQGHESSVLKLSFIDEGIQLLSSSSDGNLKIWSLQSNDCLATFDAHEGKVWAMDVTDDERTIVTGGDDSTIAIWMDRTEESKEKEQIRMEESIQNEQTLQNLLQQKHWPKALKMAIRFGHPLRCLTIMKEMLLEYSQTKILVENLVHELRRDQLLTLLDYSVHWNTNSKHWIIAHCVIRACFEQISPEEMEKMPEFQKKITKLLPYCERHLSRIQRLRQMTTFVDFVFEQMKLPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I857</accession>
    <name>A0A922I857_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_000072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9525943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I857"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9525943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="150" mass="16435" checksum="C717197DAB838033" modified="2023-02-22" version="1">MYIRLKFFFAADLNLSRDMQLEDILSQGEEKCIQKPCVQQQQCCPGSVCVDLHSQHSQSPLSLSSSMNNKQRPVTTGTCLPIYGVNEGDSCTDDGDCETGLRCMPQTILITNDDDNNGRLSLPSMHSLSSSSSSSSSLSSSSLQSYHHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I8I0</accession>
    <name>A0A922I8I0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">DERF_000408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Derf</strain>
            <tissue evidence="8">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I8I0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH9526310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="432" mass="48862" checksum="342C25EDA5CACB06" modified="2023-02-22" version="1">MMTTTTLESLSNMDHNNSDLDHDHHTSMAMTTSTISSPLLSSILNTTISNSSKLINKLSTTTLPSSMIINDDEAMMMTIDDNDDHMVNSDDTNILIESWNRSGFQLPDINTLPTPIIILSIIAIVFILWMVIKFIQALWTFFICYMLGFGAKWRPGSDSWAIITGSTDGIGLAYAKAMAKKGYCVFLLSRNQQKLDKVKADILNECPKCPQVKTMAVDFTLDTIYKHISDEIHALNGHVHVLINNVGMAYKYPEYFTKIPNSDQFITNILNCNILSVTRMTHIILPIMEARRSGIIINVASYSALFPTPFLAIYSASKIYMDYFSRALHSEYSDRGIVVQSVLPYYVSTNMIRNPTISFMIPSPDQFVHSALKTVGVETRTYGYFAHNVLAFFQSFIVKFIIGNNLNTKIAYFRMKRLRKGCYKRKGLSHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I957</accession>
    <name>A0A922I957_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_001716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I957"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9527707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="63" mass="7001" checksum="28BBF4F3C176C8B0" modified="2023-02-22" version="1">MQIGSARYRFNFHSLANSVDMNEELAPSSNTTRTARPLITVVNVLCILLPFCVSNDGWLVDCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922I9N8</accession>
    <name>A0A922I9N8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922I9N8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="61" mass="6843" checksum="21F6BB9879FD41E5" modified="2023-02-22" version="1">MLAEELLLAADDWDVLLVVVDVCVGDGDNDMLLEYIAFGFSFLSIIFGYEDIDGNKLDRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IA89</accession>
    <name>A0A922IA89_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PPP2CA</name>
        <name evidence="10" type="ORF">DERF_001131</name>
        <name evidence="9" type="ORF">HUG17_4363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IA89"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="188"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7641319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9527087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="383" mass="42809" checksum="D64E60B55229BA95" modified="2023-02-22" version="1">MSSNSSGDPAASGGSTTTTNTAAVNKSDNESSTTINTVNNNNNNTSSSTTVNQQTAAATTPTSTTTLQISSGAGGDMLQFNKDLDQWIEQLMECKQLTESQVKQLCDKARDILTNESNVQDVKCPVTVCGDVHGQFHDLMELFRIGGRLPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYKDRITILRGNHESRQITQVYGFYDECLRKYGTSNVWKYFTDLFDYLPLTALVDRQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGHDISETFNHTNGLTLVARAHQLVMEGFNWCHDHNVVTIFSAPNYCYRCGNQAAIMELDDTLNYTFLQFDPAPKRGEPHVTRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAD0</accession>
    <name>A0A922IAD0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAD0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="327" mass="36214" checksum="3E9F9AA35B1E4E4E" modified="2023-02-22" version="1">MASTTNVQKEIDLLTNEWKTLRLPHKLKQYRQYEKCLERLKLMASSSSSSAESKESLIEQINQLYIKLDKSVICGVDQCFICGNCNDGGNCSLTTTTTKSTIYQKVTMDKQHEKQLDHQINDHNNNSVIISDDHDVDQLNDSNRLLQTTRARLRSTSPPIMATNKINPNANVIESKKSTLINQIGISDCDRQNVDDVVDNKKCNGIDSKQNSNNSNGDQINDNESSIKILDEELPDDSSPSVGRDCQLSKNLNIESSSSSSTLSLMMPRPFQKLSPSSSSNDSYNGSSSGSTTTTIISGRSPPIISSYKAYKDFINNYTTTTTTTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IAV4</accession>
    <name>A0A922IAV4_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_000924</name>
        <name evidence="6" type="ORF">HUG17_4191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="4">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GcvH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IAV4"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF3">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="77"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7641147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9526866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="183" mass="20951" checksum="C6374C7207D25BB5" modified="2023-02-22" version="1">MKQIFSRSKVFLSCNRLILGQQQKKFLSQITSSNNNTRILWSRIIRPIYSSSAKFLSDRRYSEKHEWVLLDPNDKTVGTVGISQYAQEALGDVVYVQLPEIDSEYNQNDEIGAIESVKAANEIYTPVSGKIVETNKNLEEKPGLINSSCYDEGWLFKIKIKDSKEVDGLMDEQAYEEFQKTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBC7</accession>
    <name>A0A922IBC7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBC7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="241" mass="26743" checksum="C1255D2CF5A05466" modified="2023-02-22" version="1">MNRDDTDLFHFGLLNFDNDAQTNEAIGYPMAAMCVRMSSDQGVLHFTPINVASYVLPRPASRNHNSIVSMILAQCCFEMKKKMPCICGSSNRIMLESADSKENRQQSCTSVSAKFQNYEASLMLFSMLPRYNKSQVSTSELSMTPPIATQVSRSVCDNGQHIVRIDNQVFHCSNKNTENDPSAGSPTETLLRLLLPLDVQVWSTFRPNIATTRMATLARPKTSLKHPIGSSDGRCVQRAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBF9</accession>
    <name>A0A922IBF9_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome biogenesis protein BOP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BOP1</name>
        <name evidence="11" type="ORF">DERF_002862</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBF9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="10">
        <location>
            <begin position="447"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="712"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="804"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="809"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9528952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1115" mass="127770" checksum="457D09E7A6D15590" modified="2023-02-22" version="1">MSIAQNLSSSTFPSHYIDNIDSDQQDINGTTAAISREVPKNETNSKLESLGTTQISPSKNVSHIGEVVTSLPNYTNETTSTTKSTTTATDFQFDQETTNFFNRSGTISSTKSTKSFPPHTPQTTTTIMPSTHSTTTTSSPNKAKTTTTTVKPDTDDVIKKMYVHLFIFIFSAIGKISIADENTSCLEMIENEFNFGEDFSENIQNLILVNLNDDLSCQSFIEYLSLKLRESTHSYWKELDEQGRRRIASHLLPLLKYQILNGTNGPVKSIIEAIGFENIFGPREINCSQQIKQTFDLSHSLSENLIDHLNLSNHKECRQFIKISKNYLFDRVQLINSIVFTIGLFYSIRSLEYLKITLQDISDDDGVEFSSTDDVDDNEDLFAKVTPENGEEANIALENKPDVRSIQNDTEPVFTGENKAVINEYEYDSSDEEDVLNTIGNIPYEWYKDYVHIGYDVDGRKIIKPKNDDQVQEFLNQIDDPNYWRTVKDNLAGQKVVLSDQDVNLVKRIRNAKCPDPTYNQYESFIDFFTYEKMIHPVTNRPEPKAAFIPSLSEKRLVSKLVSAIKKARLKPKPVIKKPKPFEFNYDLWEKDGEKNPRLDRYIPAPKPKPPGHEESYNPPPEYLFTDEEEKEWLEQDPEDRKINFIPRSYSSLRKVPAYPDFIKERFERSLDLYLCPRVRKNRIRVNPEDLIPELPKPSDLQPFPSIQSMVYSGHEANIVCITVEQSSQYMASGDKDGVVKIWEILTGRCFKTLKFSGPISNLSWSPNDSKSIVAIVVENMVYIINIGLGQRQIVQQTEQYFENLNPENNDDDGPSGEEESNIPKRKENPVCHWKRIHQENDAEDWLKGIRLIIKHDFEIKQLAWHAAGEYISTVMPHASNRSIVIHHLSRMKSQVPFKKIKDIIQYVKFHPTKAYFFVATKRTIRIYDLIKQQMTKKLSANCNEISSMAIHPGGDNIIISSMDPRVQWFDLDLSDKPYKTMRYHKKAVRCVDFHRKYPLFASSSDDGTVVVCHGMVYNDLLQNALIVPVKVLKAQNVKKQTEIMQCLFHPNRPWLFAISSNTTKRIRDPSLVTLHMLLFSNSSMASSISSFEYPRMIQRSIASAIFTTRSSAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBN5</accession>
    <name>A0A922IBN5_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Helix loop helix domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Max dimerization protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MXD1</name>
        <name evidence="10" type="ORF">DERF_001338</name>
        <name evidence="9" type="ORF">HUG17_4542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
            <tissue evidence="9">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Derf</strain>
            <tissue evidence="10">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7641498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBN5"/>
    <dbReference type="OrthoDB" id="5920083at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11401">
        <property type="entry name" value="bHLHzip_Mad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF54">
        <property type="entry name" value="MAD-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH7641498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH9527316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="228" mass="26014" checksum="013E31100B2BD864" modified="2023-02-22" version="1">MSIADLLQAAEYIERREREAEHGYATPLQHDPNKRRSKSKKSLGSRTTHNELEKNRRAHLRNCLEKLKEIVPLGPESNRHTTLGLLTKAKAFIKNLEEKDKRHQSTREQLIREQNYLRERLGQLQDNTSFIQYPTIPKRRSISECSSGVSSTSSNSEPETSETTELFESNENAARLLHSFANFKVQIESPDQQNINQWPSTLSTTTTVNECIVGGGVEQSLIINGYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IBY1</accession>
    <name>A0A922IBY1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_001939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9527957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IBY1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9527957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="84" mass="9998" checksum="738FDD219B563E6C" modified="2023-02-22" version="1">MKKDKRLCAIRSSIEQHLHINADIHHQYSNNLCIISVDTNLNQVLTRYRCNREDIKPKKKPNMTKRRNHHYNQETKCGKQTELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ID09</accession>
    <name>A0A922ID09_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glypican-4, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GPC4</name>
        <name evidence="13" type="ORF">DERF_003655</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cell surface proteoglycan.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <topology evidence="1 12">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glypican family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="KAH9529792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ID09"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:regulation of protein localization to membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Glypican"/>
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    <dbReference type="PANTHER" id="PTHR10822:SF30">
        <property type="entry name" value="DALLY-LIKE, ISOFORM A"/>
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        <property type="entry name" value="Glypican"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010260"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9529792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
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    </evidence>
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        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
            <tissue evidence="3">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
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        </location>
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        </location>
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            <begin position="109"/>
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        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KAH9529306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="297" mass="34293" checksum="BC9670B8000DFB1B" modified="2023-02-22" version="1">MTMKRKFFYCLSMTCLLILNFKLLLLFEHDQIVWASPVLVNDNHNNNNNNQTIQVQLFKYNERPLGSMNDHHIGQSRSNNDEETTTILPYFFQHSSILGPSSSSLNITNNSTYYRSNSDSDDNNHPSQPRTDLYTIELTSPSVSQHHHQLQHHSRQAKLDDNIVFNYKCPKQHFIHPCDCLELDKRAEMYDDGSGDSGADDITVNGTPTFEMIEEDPIHPDLIETVVLCKNIRNAQVLTEAIRGFQGHRVNFMVLDGCKLPPFPNNLFKGIHIVWMEILNSTMQFHDNFFQNTRHCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922ID91</accession>
    <name>A0A922ID91_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_002903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922ID91"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="323" mass="34912" checksum="A60F9615DD2B6BBD" modified="2023-02-22" version="1">MVLQQTASTTALPSSGHPHHHHPLPQHSLLNSPQPQQQSSHPHHHHHHQRHQSSTNGVAAGTMSTLGIRCDSVGPSSTQPPPAHLSTYPAHHHPGHVHRHNTTIGSVDCSGLAICVPLLHDGSNAGTTAPSGIVSPPSPTSIAHQQHSRTFAATTSSADLSSSISNSDPNERPSQLANAYLTAAAVAAAQFDSSSVFTNTENGDGSSQSHHPIRSSGHHYRRHHNNHHHPHTTHHQSNGSTRSSQISSLTSPQQQPSVTTSAINVVEDVDQTQQPNIGTNNGHHHFHRTRHYRINPCDAPEDDILSRKKYIRVLFQLAAWPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDF8</accession>
    <name>A0A922IDF8_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_001991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IDF8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9528015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="175" mass="20170" checksum="A1917855BE349D72" modified="2023-02-22" version="1">MKNPNTPFFIMFDHKPTKILTANKINILAIWLVIGSILFYSASKYPLQETFKTVYSHIPGWIEPDDDVGRDIFDLINSRGFEYESHFVETVDGYILQLVRLVNPFTKYNQTRYRPVILSHGVECTGSEFLINNPGYLNSDGTYLEWDENDNLINGSEKITNTLGFTLCSHGYDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IDX0</accession>
    <name>A0A922IDX0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">chs1</name>
        <name evidence="16" type="ORF">DERF_002972</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">Derf</strain>
            <tissue evidence="16">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000139">
        <property type="entry name" value="Chitin synthase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055120">
        <property type="entry name" value="Chs-1/2_IV_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF42">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23000">
        <property type="entry name" value="ChitinSynthase_IV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="643"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1150"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1187"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1210"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1241"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1273"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1507"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1570"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase chs-1/2 N-terminal putative transporter" evidence="15">
        <location>
            <begin position="239"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1699"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="775"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1706"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1716"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1728"/>
            <end position="1738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KAH9529063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1760" mass="204369" checksum="D9D309744ED4AF89" modified="2023-02-22" version="1">MEHSKLSRLNQSKMNSNFILRRKDSPNSISDNDSDPQQSPSPSNKFRHRDSVFVNKNQIEQRRISKGETDDDEDDDDELNRNTQFNMQRQSSSGSQVRFKLNENDISDNEITVQNNIPLKRKPEPIIIDDKNRNDQTMETKLKLRPTLSSSSNRFSQTTPTSANKRISFAQFDHVFKFDHPTTSTSKNEDKNRKASIYDHMKKINIDNQDDDSSDETKTYPWDSFKSIPTQDEDSSSSSNWVKFFLKLFKLLSHAISFLLVLVMAIIAKLFLHLMATMTRVDKSIQICKKNLLDDSYDHSALIPLYTRLELKSDERIAWIWMLFFVLISPDIILFFRSIHSCLFKNYSLPDFYATLMIFLSSTSEVIGISLLVYVVLPSFDTIVGLMITNSLFLIPSLFHFMRAIKMDNPEQRQSISNRIMKILYLIAFIFQIMSIIVWPILLLIKDSKYKSTTIEDNVFDPRRDDIHLSWIIPIACILITFGYWENFLGNNNPDDDSSSKIQNRFIQSLYQIKDNSKRSKFAIYLFVSIWKCLLHLAIMLVIQGLLAIHQPKTTDANDNDVDDDSNMNRMADMMNFMFTNFTQAFRQHPITLVANAGFNYRHPTIDSDPMLPIWIGLIQIAAAFFCYQTINFVCKICIQPLGFGLPITMAMPLTVSLTHSLGQIAINDRCWLPDQWNIFDYTFFNVPYDIFDHKCWINYLFYAIWMMTFISQIIITNHIWISSKERLASTNQLFMLPLYSSAFIDQSLMLNRRRNYDNDIWSSLLNENEADSSMDGRKSPMQEFQRKSSKENDDNDIRIYACATVWHETADELLQMLKSIMRMDKDQCCRSLAVKCLQVKKRDVDFYQFETHLLVDDAFKKGKYYKKNANDLDINEYVQTLIDVLDEAAQNVHQRYITIKPPIIHMTPYGGRIEWILPGRTKLIAHLKDKSRIRHRKRWSQVMYMYYLLGYKIYQQEPDRRDALMKNTYLLALDGDINFQPDAVLLLVDLMRKNSKLGAACGRVHPVGVGPMAWYQKFEYAISHWLQKATEHVFGCVLCSPGCFSLFRASALSDTNVMNRYTTKPTEAIHYVQYDQGEDRWLCTLLLQQGWKVEYSAASDSFTHCPEGFDEFYIQRRRWAPSTMANIIDLLKSYRNTVRANDDISSLYMLYQAGLMLGTILSPGTIFLMLVGAVNNSFGLKNEISFYINIVPVLIFVLAGFFTDNKKQILVAQIFSTFYVMLMLAVLVSTGIEIYDESIFSPSVIFFVGMLTVFIISALIHPQEFTCLIPVVIYMLMIPSMYLLLTLYSIINLNVVVWGTRENPQTVETKQPVQPTPKQSDNFLHDVRQYFRNRSRKLEVLNCVCCGSSRNDDELSLLHEIKDSMHQVRSDMDKMKTQNSVGSNIIRRMSLWNRRRSTIAEPTPDQLEKDPLLADDAQDIIDEDVLLNIANQPISDEVKEAEEISNLRRPRWIHNKHLKNANTHPIDEEEEKFWTLFIEKYLKPLDKNEEHEKKVKSDLINLRNQAFFALSIINIIFVLFVYLMQLHKDIFSFEITLSQTQNGTKTVLIEDEEHDIPIYVTKKIAMDPVGFILILFFGVIIIIQFIGMLLHRMGTLTHLLAFTDLNFFQVRAEDIKEKRQLDQNSLQLVQSIMNDTEESDQDYGHFDMEEFFLPAMLRVMDPDTAYEMIKKMKPNTNVSKKKLGAELSRRSSTFVGRSTFYTMPEENDENTDDNSYDKQHFKENVSDSDSIDMSIFSRGSSPIRKDAPISVESDDSTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IF52</accession>
    <name>A0A922IF52_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Homeobox protein hmx3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HMX3</name>
        <name evidence="13" type="ORF">DERF_003216</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">Derf</strain>
            <tissue evidence="13">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the HMX homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IF52"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000053">
        <property type="entry name" value="H6 family homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051300">
        <property type="entry name" value="HMX_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46110:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HMX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="476"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="478"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="141"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="641"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="641"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KAH9529326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="682" mass="74765" checksum="7BA00A688D82C9F2" modified="2023-02-22" version="1">MAIIDKNGDHHHHHHHHHHRHQQRQRYQHNHLLHNYQPNATDSITSKSSSSLSSPTIPIETVTSTESDQELNKLDSLDIITSKTTTLFNHHSITTPFYHLTDMMNYNGHHHHGSQTPTTSIHHHHNHRNHLEQLDLLNAKNQDNENPESSSSSSSSSSLLLSNSTDSSTMAKSTRINTDKSNNQCHTNNNNLNKSLESQQNGLLQQQQQSKSGNDNKNQRLNFSISNILSKENHNNLVNNLRDNLLAANPLYSRPTNQLSFDPMTSLLSAHFLSGYPLSMSSSLSTLNDQQKSQILPSMLFANANVNAAAAMAAAAGTKNKPSPWYPWSLTMSPTALLSGNTTISDVNFSSMFASNKESKEDHFLQKLNRDSNNKRECSDKSYSPSLFSSSNPGSPFEGNNGNGPLNKCSIIANNSHQQEIELEDDIDYNDSDTCSEKDSPIQRNCLFNSTINNNNGNIDKSSTNDQNSINSLSNKRKKKTRTVFTRSQVFQLESTFDMKRYLSSSERAGLAASLHLTETQVKIWFQNRRNKWKRQLAAEIEAANMAQRMRAVPILYHQQSDGQTTTTSPTPKANNLVSHAHTVADSNSIQALTSYYYSSTHGNGSNSTGGFSLSNSVAAAAAAAAAAAAASSAAIISSSPHLTTTTTSSPNVSTSAVSINSGSSTSTSNSIHRSVTISGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IG28</accession>
    <name>A0A922IG28_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cklf-like marvel transmembrane domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">DERF_003536</name>
        <name evidence="8" type="ORF">HUG17_5459</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
            <tissue evidence="8">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Derf</strain>
            <tissue evidence="9">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000004">
        <property type="protein sequence ID" value="KAH7642414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IG28"/>
    <dbReference type="OrthoDB" id="6258237at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF97">
        <property type="entry name" value="RE01453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="51"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KAH7642414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KAH9529665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="208" mass="23328" checksum="AFFC325E7BD3A3D9" modified="2023-02-22" version="1">MSTSNTSQSPSSNELIYVKRGAPKYSQSGMTIRGKAQSTGVVDDLYFNPQYFCTNPGVIKLIELLFGIVALSCISPPLTWFSRLFTFFLAITFAITLILCFAYLVTLKNVFFPKFDWLTTELSFTIIAAISLFITALIHILYSCREDYRYSLTYFNSYLGTSYFGTYITSGVFGILNSIVYGIGAYFLNKERKYGGNIVAPSGDNDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922IH39</accession>
    <name>A0A922IH39_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hydroxylysine kinase</fullName>
            <ecNumber evidence="8">2.7.1.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_003313</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19049"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57882"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58357"/>
            <dbReference type="EC" id="2.7.1.81"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.81" evidence="8"/>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922IH39"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047992">
        <property type="term" value="F:hydroxylysine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050249">
        <property type="entry name" value="Pseudomonas-type_ThrB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21064:SF1">
        <property type="entry name" value="HYDROXYLYSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="11">
        <location>
            <begin position="67"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9529428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="398" mass="46045" checksum="30147A3CDF547C9E" modified="2023-02-22" version="1">MNFKSSFLPFSTNKLFTTLQMMNMEQQQQQQQQQHGEQNEQTKPPLLGDQDIITLCATYYDIHVERVKELNSYDDRNYIVHTSNGDKFVLKMTNSYDSEQPGLLNGQNNMILFLSSQNFNVPCPIKNIHGDYLARIQLPMNNPVNPAKTFAIRLFTYVDGIILYNVPIERQLLIGCGQFLARIDLALEKFDDKVIRTRKFFWSLANVPKLYDYLNYIKIPSRNELVLKCVKDFEQIIVSSLDSMKQSYLHGDFNEQNIIVRKIDNAYQIYGLIDFGDIFYGPRIYDIAIFIAYVMLLDTDFDCILEAPKFVLQGYCSLISLDNQDINNILICARARIAQSLTLGAYTHSFQPDNEYLLTTAKKGWSILERLCSFDDDQKQLIKHWMDAANISKTTAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KVM7</accession>
    <name>A0A922KVM7_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_005164</name>
        <name evidence="1" type="ORF">DERF_015757</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KVM7"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9491018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9521513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="69" mass="8525" checksum="A090E91958F3EEA0" modified="2023-02-22" version="1">MKCLPLRMIDFSFGLNSKSYRCCRRRRRSRLCLRTFLIHDKWRKEKRKQTISDSDETKTTIMVNYDYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KXM4</accession>
    <name>A0A922KXM4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_011974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000006">
        <property type="protein sequence ID" value="KAH9501107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KXM4"/>
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            <begin position="12"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9501107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="356" mass="41897" checksum="3DE10CD39676A142" modified="2023-02-22" version="1">MNPYHLSRYIKFSLIITIFLFLLYTVIELLIIKQYYIRRYVELHYQYENNLHSISNDVHYHHHHHDDDDEGILIPTNVDEEIPIEEMIIPINTTDNTVVAAGNQTTKQQQRMPKAEAQILPDDIPDESFENPNLTMESDMTHSFGDTTVNNNQVKERFCPIFCFAILTFVSLLLRLRQFIFENNDEFEWFKYRSLTNAERFHHEIKKMDAEQLLDWMTKTDLIEVIISFIETILVFIYTLLLRRYPARIHGHPYVQYQQQQQQQQQLNGRQNNHHPVDHVRIIPNGHAIEMNELSNTDGTDTSMNDQRQINVDNNNDDDDNGNQRLLSTNGQNDHSNRIATTIVMSQSCARNSLIP</sequence>
</entry>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
            <tissue evidence="2">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
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        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
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    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH7636916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9506545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="131" mass="15300" checksum="E7C4F7563CF3213D" modified="2023-02-22" version="1">MTKISNNPNSEQQHHQTSNEESYCNNLHLRRLSLKNVMGKSIHQLNNQIDDHYSLYGGLDQPFQIPRPKLIKLSIRSTSTATPDYDMTDDDGNNNNHIMERPYSYIFPNNYPSNNNEYHNNNKQQSISSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922KZD1</accession>
    <name>A0A922KZD1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
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            <taxon>Pyroglyphidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
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                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000005">
        <property type="protein sequence ID" value="KAH9506635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922KZD1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9506635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="268" mass="32441" checksum="20911EE6D803E3EF" modified="2023-02-22" version="1">MESSQTLMRKKVNKPAINDNDVKEEGDCLKIHQRIERFYRIMRKDFVENIVHLDQLGQQRFNVHDLKRMAAATTLDWQQLQYHFPLLDSKQDVYQYQEIHCLGRSNEQFLFTNGMIKSNKYFDQCIDILCEQYEIFYQLMTECYLTIQLLIQPLHNCNISDHELLMAMIDTFESYRNFAIHQQQSLRSIINGKRSNLITKIATHPQYDDIRQIFFHYEHNKFIRMICDQYGHLYYGYHYVYDQVMKNGNILGTLFRQLYRQTHHKQEL</sequence>
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<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L112</accession>
    <name>A0A922L112_DERFA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
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    <organism evidence="1 2">
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        <name type="common">American house dust mite</name>
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            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9510502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L112"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9510502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="82" mass="9915" checksum="A123CD075043994D" modified="2023-02-22" version="1">MRIVKYKRENCSSDLIIIGLTTYIWFRFSLTSNKITKLIHRMITLINNSMSFNEFPFAIDYDMIKRIIYKMAFFYIPSNNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L113</accession>
    <name>A0A922L113_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Autophagy protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ATG14</name>
        <name evidence="2" type="ORF">DERF_013887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L113"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097629">
        <property type="term" value="C:extrinsic component of omegasome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097632">
        <property type="term" value="C:extrinsic component of phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035032">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035014">
        <property type="term" value="F:phosphatidylinositol 3-kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016240">
        <property type="term" value="P:autophagosome membrane docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13664">
        <property type="entry name" value="BECLIN 1-ASSOCIATED AUTOPHAGY-RELATED KEY REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13664:SF0">
        <property type="entry name" value="BECLIN 1-ASSOCIATED AUTOPHAGY-RELATED KEY REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="592" mass="69935" checksum="7DB7D5362C7F0423" modified="2023-02-22" version="1">MITDDDEMLPGFSRLSLGDDGHVYNSDCDDDGDGNDGNDGYDDNDEIMNVRIQETNHHHHQPYIDISNDHQFNNFLMDQQRKHHNFFVDEQFENQSENRHFKCPICLKEMRKLFCPNCIRNGDFTHSTQNFLERFADKKLKFIKLKEQQLRDCNDVQKFFENNVTKSSMTIKINEIERNIRTIREIMNEKRSIISDMKKLLNKHERERLLYHKKQIDVKNKMNRCKNNHATLSYNLNNFYRKKYSIQDELNTLIRKRLNQLTMYVFPIQENIFTTTTINNQQHFDDDDDDDDDLNIQSINCDKSEALPLLDCAINDDDDDDDDFDDNNDSVVTIKCKNDYNKKKKCESNQTRKQQIIRYKIVDSWINLDENFEAATHNNAIECLDVGDNSFRVDHRRIMSALSYLCYLTNLFALISRIHLPRKILFSELTCKRMKRDQFHRRIAQLNANIVFLCCWYRVDIRNELQPKHSIRNIKLALDVAIDAQTNSDYNHLEIRHNLFRMIHNELFMYDMVKITKKSKTFDTFPTTIDTNDNDDDSNKTTTAVADEQDFDFVENNIPDLKLDDPANNEKQPATGILAALVSSIYKRTTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L1P5</accession>
    <name>A0A922L1P5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">DERF_010143</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Derf</strain>
            <tissue evidence="12">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L1P5"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="338"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="493"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KAH9511704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="537" mass="58887" checksum="17E7C0D2FC6B4E6D" modified="2023-02-22" version="1">MGQAFSEPVTEKESSTEKNDKFLVASSSIQGWRISMEDAHTILLTMPDDPEASFFAVFDGHGGAKVANYASENLHQGLCSHRLYQEGHIDEALKNIFVEFDEMMFNNEKMRDELAGSTAVVVLIKDHQIYCANIGDSRAVASFAGQVDPLSIDHKPTCEDEMNRIVSAGGWVQFNRVNGNLALSRAFGDFVFKRNEKRSATEQIVIAYPDIQTRSLTSDLEFIIMACDGVWDVMTNEEVVEFIRRRIFYRREPVAICEELITRCLAPDCQMGCGIGCDNMTVILICYLDGSTYEEFCDRITNVYQMIPGNIISSTNNDNDHNVTRHIIGPITHLYDFDGDDNDGSGGGGGGVNRPNGNNNDDDDDDDNDDDDDDDNSDENSSHSSISSVDNIGTTMNTSKTITTGNETLTSNTNQTSSSIIVNVDSSTSINGPKLSVLPIDPHPHHHHNHNHPQQQQQQQQQIQNNPNTSIYANNNAHQTSIQSIISPGHMISSTTTTATTSSSLSPNSSSSNHKSPPSSSTISINITSAATSPCHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3M3</accession>
    <name>A0A922L3M3_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat shock protein 60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HSP60A</name>
        <name evidence="11" type="ORF">DERF_007847</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3M3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000019">
        <property type="entry name" value="60 kDa heat shock mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000031">
        <property type="entry name" value="60 kDa heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9517153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="506" mass="54898" checksum="B6B26D3E17F5021E" modified="2023-02-22" version="1">MYRVSRILRTATHHLSRVNGTQTTSAISASHMHESRRGTAKDIKFGADARSQMLQGVDILADAVAVTMGPKGRNVIIEQSWGSPKITKDGVTVAKAVELKDKFQNIGAKLVQDVANNTNEEAGDGTTTATVLARAIAKEGFEKISKGANPIEIRRGVMSAVEHVVDKLKSFSKPVTTPEEISQVATISANGDRKIGDLISDAMKKVGRDGVLTVKDGKTLSDELEVIEGMKFDRGYISPYFLTKGNKVEFQDALLLITEKKISTAQSLIPALEMAVNQRKPLIIIAEDLDGDALTTLIINKIKINLQVAAVKAPGFGDNRKNTLHDIAIATGGIVFGDDANIHKLEEIQHNDFGQIGEVTITKDDTLLLKGKGNKAEIDKRVQQIREDIENTNSEYEKEKFQERLARLSSGVAVLKIGGSSELEVNEKKDRVTDALNATRAAVEEGIVPGGGVAVLRCIKYLDDLKPDNEDQKIGIELVRKALKQPCMQIVQNAGVDASVCCQQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L3V1</accession>
    <name>A0A922L3V1_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Matrix metalloproteinase-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MMP15</name>
        <name evidence="17" type="ORF">DERF_008027</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">Derf</strain>
            <tissue evidence="17">Whole organism</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L3V1"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000002">
        <property type="entry name" value="Matrix metallopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF308">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037755364" evidence="15">
        <location>
            <begin position="30"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="16">
        <location>
            <begin position="122"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="14">
        <location>
            <begin position="323"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="14">
        <location>
            <begin position="372"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="14">
        <location>
            <begin position="419"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="14">
        <location>
            <begin position="467"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KAH9517348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="745" mass="84974" checksum="F00942587BF5F21C" modified="2023-02-22" version="1">MMMMMLNHCNYLVFLALICIIIKQKSAIAKKYSAKISAMHFLENYGYLPEMGDNELNLLDHKELERAIKLMQKFAHIPQTGRMDANTVAVMKSPRCGVPDIVNNVQSSSSSKYHRSKRFAVYGPKWKKMPIKWNLISPSANVSSGQARQIFSRAWNIWAKASDRLKFEESADPKADILIGFYAGEHGDGKRQKFDGPGAKLAHAYAPPNGDVHFDDEENWLDKNGPSLFWTALHEFGHSLGFSHTADEASIMFPYYRDHGENFTLPEIDRAGVQYLYGGGTDLDNTKQHHETVTKSYDDRNKQINDGTTISPTIKSFEHVMCNTNIDAIASIRNEIFVFKNQSFWWVKNDLTLIRHEPIPISQYFIGFPTDIGHVDAVYERRSDQLIMFFVGRQYYLFNSNLYHAGPLPLTDLCLPEHVERIDAIIDWAVNGRAYIFTGSVYWRLNSQENCIEMDYPRDISVWQGIPTNLDAAFTWRFDSVTYFFKGSSYWKFDNRKMRVQNHNPGRIRDFLFRSIDCRRIAIIHQPDEYNHIGQYDSLTNLDSLKKEFPTNVIAIELDLRDWTATRKALEPYADKIDMLVNNAAYAKCTPLGEITEQECDDHYSLNVKAIINVTQCVTVGMKQRRSGSIVNVSSLAGLVGYKDHLVYGSSKAAVDLMTKIMALELGPYNIRVNSINPGVTNTEMAKVGWSDPERRDWMLSRCPLGRFNEPVEIAQAVLFLLNQKSGLINGVNLPIDGGIYTTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L430</accession>
    <name>A0A922L430_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_009500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000004">
        <property type="protein sequence ID" value="KAH9511015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L430"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9511015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="64" mass="7585" checksum="2F409F0A3320AC28" modified="2023-02-22" version="1">MKLSKKVKLNFFVGKDQNLESPNSHILGTIVLKILKKYLYIKGMKVSRLENNDWKKKRFVLHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L4N4</accession>
    <name>A0A922L4N4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_008347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L4N4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9517706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="73" mass="8793" checksum="58706B6467F95F4E" modified="2023-02-22" version="1">MNKMGVRRGVRGSFRGSLRRYGSAEYSRRPYRHHNWVFRNGEWRIAFDDGDEVTLMYAKLEVCLFFLNLYLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5B2</accession>
    <name>A0A922L5B2_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MPC2_1</name>
        <name evidence="11" type="ORF">DERF_004243</name>
        <name evidence="10" type="ORF">HUG17_0404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000001">
        <property type="protein sequence ID" value="KAH7644866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5B2"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KAH7644866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KAH9520539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="120" mass="13642" checksum="8362701F89E5C281" modified="2023-02-22" version="1">MSFIYRSVIRKIDPLVPIKLRPIWEHDAGPKTVFFWSPVIKWGLVIAGISDLSRPVENLSARQTASLAATGLIWSRYSLVIIPKNWGLFSVNFFVAATNIAQLGRIYFHNDRKSIKDSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5D9</accession>
    <name>A0A922L5D9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_008346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5D9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9517705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="535" mass="60994" checksum="B08CE6057645CB2E" modified="2023-02-22" version="1">MAHMYYHVSSSKGTKIYRLHGRNFYADIVWTPSSYDWNRLVFSVKLFKLMSDQYNNHNHNDDDPPMMKPSTERPDFDPEYLLLENVSTFLIMPTDIEVMVFFTTNEFCIINYFTKNCGRRSTRDLFGCDDDDDDDDGYSEFSDGDDSDRPHNMTIVNIMENDQSFNEPSNNNSNTASMTTAKILLDTIKKSTSNETNKQNKRKMSTLTPPMPLPTMATSTSTNSIVKNISTADSIVSSSKFVSTKTTTVMPIFPSKNDDDDDDNGTQPNETNLSRATTAVQRPSITTDNSIVESHEKRNKKDEIEQIIVTTESSSVLCHIITATNDNNNKKNKKISKTTKIPPIHSIATVTSNYDLDSNKPTNSHVIENHVVNKSIHHSSSEKKPNKETHDDVDGDVNEKIFSQEITCDIDCVMLKLKEMKNLDQRKRGMSKNFDNNNDDVDEYLSSSNNYSIKSIINIMIKSDIIHGHFLKNGSFIIGRIIFRALKFVIITSLIIGSIIMLIILSIHRLRFKDFRADIFLYIMLSFFTQKLKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L5Z3</accession>
    <name>A0A922L5Z3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_007414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9516689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L5Z3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9516689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="472" mass="55687" checksum="580EC591F80315D2" modified="2023-02-22" version="1">MHILDSYENSLPKIINHQSIDPIPNTKYKRLICSKVFENKSKCLNGEQPEVFAFDQIISRHNCSFQFELLDDLIILFKANNHHILYRINPRFYDELQPNSFVEEVANRIDSNVRLQKVIRCQFYPYDLGLYSSLTHDRLSIFDTVRQELVQTLPNRQMTYTKKFYQMDWNPLTYVSIALACDNSEALIFDHRTDHTSLSLIVNDPCTKNNESTRCQVVYWSPQDENGLFIGTRAGSIIMYDIRQSRKPLAAHLSSHLYRHPVAHISMSPDHRNIITIHPTYADRNIFRWKIKPNIMNRNQFLKEMPLFVIKRLSHSNVRNSFNDSSFRKNERHKLEDIHFEHMQPYITNEYASLFSRTINGQINNLNYAFEESKKYDDESVLSRNTHFCPKKLSLSSTDDDFDHHPRSTLFYGYGSTNKGDEPFPAIFYKANKVFLVRRLRFTNDEADIQQNFRKIQSFESEDRWSSSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7K6</accession>
    <name>A0A922L7K6_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thr operon leader peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_004302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9520602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7K6"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9520602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="24" mass="2609" checksum="F5F5D21A48811CD9" modified="2023-02-22" version="1">MKFSSTIIITTTTTTSKSTKTQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L7N3</accession>
    <name>A0A922L7N3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_006392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9522834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L7N3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9522834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="277" mass="31998" checksum="CCA03440A0CFB109" modified="2023-02-22" version="1">MAILMALIFENAPFISSSPLPPSLAPSIMRGVYVTPIFHHHQNDQSMINQLLMNDDDDGGDNRIIGWTNYPSSATNTNTFHNDDDGDGDDDDDDLDVDFDGLNNYKEQPLKTSTTTTTNQQQLSPQAVQKRSIQMEKKNNKESLYDWLIKNNNNQNIKNGRMKRSGIADQRLAELLELARLDMIRKLVRDSTTHHSSTSIDEDVAYGLIDPHVIGRRRRRRHYAESVDEQKHRSTTLQNEQLQRKINDNRPVRLLLLSREQQQKNLINHDHHQQRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8B9</accession>
    <name>A0A922L8B9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Ras suppressor protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RSU1</name>
        <name evidence="5" type="ORF">DERF_000472</name>
        <name evidence="4" type="ORF">HUG17_8275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
            <tissue evidence="4">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="5" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000005">
        <property type="protein sequence ID" value="KAH7640806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8B9"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000034">
        <property type="entry name" value="Ras suppressor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF45">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN SHOC-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="41"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH7640806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9526374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="285" mass="33159" checksum="F3B83AAE92A2CAA2" modified="2023-02-22" version="1">MTLGKSGCLHPCHGKNDKIIVKRLDDTHEELHMPDKGIESLQKMPYVFNLVNLRSITLSHNKLRVLSPEIDKLYNLENLNLFNNYISELPVTICNLDKLKCLNVGMNNLHTLPNGFERLHQLEVLDLSYNFLTEHSFTAEFFTLENLRALYLSDNDIEILPTEIGNLKSLQILAIRDNHLISLPEELILLQRLRELLIQNNRIKMLPPELGNMDFNSPRSIIRMEGNPFESDLSDQLKLGVSHVLDYIRSDIYRSRYSRYTMDPGPPQPKNEERYQRKLLRLKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L8R3</accession>
    <name>A0A922L8R3_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_008040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9517362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L8R3"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9517362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="326" mass="36229" checksum="DB83E3F1434FD89C" modified="2023-02-22" version="1">MFRFQFNVFAFIKLSFSIPFIYCWLNESFRKGATKMIIFICCCCCPRIRRQFLMKRRTSEFIPIGGSGVGVRSVGAGAGGGTISGGCVVTIGIASTTSSSTPINTLTTAMATTTTTTTTTKNQQQKNKQNQNQKNDQTTTTMIDQDNSGNVNNSSYDNDNHPDISGCRSSSSCINNNNDHNNNRMKKTHRRKFHKLRSISLRNKNITKSIATTTTTTAAIMSDNIITSCKHDDNDKKENDVKNQCIKQSQQHQLSTLQQQQQQQDINNVQKQQTKSFIVNNNNCDDEEIIDNNSSGNENNSVIIISTNQIVPASKTSTTTIKTTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L945</accession>
    <name>A0A922L945_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA damage-binding protein 1, variant 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DDB1_1</name>
        <name evidence="7" type="ORF">DERF_000911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9526853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L945"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000070">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="15"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="6">
        <location>
            <begin position="400"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="791"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9526853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1148" mass="129397" checksum="4B4E0DABC5EDCD2F" modified="2023-02-22" version="1">MTHNYVVTAQKSTAVFNAISGNFTSPTDLNLILDKLCRIEVHLVTAEGLRSLKEIPLNGRISVIKSFRMPNEDKDLLFIMTLKNNLMILELSRDPKHGDFEVNTRAHGIITEKSDRPSENGTLCDVNAKARIIALRIYDGILNVLKLDFKNRNIKSYNIRVEENTLIDFVFLHGYDKPVLCFIYQEDRSRHLKTYEITEDRELRRGPWLQENIESDSSMLIPVSEPYGGVIVVGQESITHIIDQNQYTAIAPPEIASSNFSCFCKIDTNRFLLGDLSGQLFILILHPNVQVASSSSAPVSPYGLKLISLGETSVSSCLSYLDNNYVFVGSRFGDSQLIKLKHDDNDTRKYIEIMDTYVSLAPIVDILVVDLDKQGQDQLITCSGAYKEGSLRIIRNGIGINELATIDLPGIKGVWQLKVDSIYDNVVAMAFVGQTKLLKLKNEEVEETFITGFDCSQETMYTGNIIADQFEMIVQITANCIRLLSVHDNRITSKWIPPSNITLVSVNDCQIICSSRNKLLYLEVIRSEIKLINEIEMEYEASCLDISSLTEKRSKLCAVGLWKDISVRIMSLPDFKLLHTEKLGGEIIARSTLMAHFDHTSYLFTAIGDGSLLSYILNTETGTLSEKKKVVLGTHPTFLKMFKTNSSSNIFACSDRPAVIYSSNNKLIFSNVNLKEVNHMCTLNSEGYPDSLILTNDSQLLIGQIDQIQKLHIRTIALNETPRRIAYQESTQTFGVITMRYDVQLEDGQMVSSRISASTLAQNITHSRSLPTMVKPTQISNHFYPNELEVYHLLIIDQTTFEVLHAHQFMVNEYATSLVSCKLGNDANHYYIVGTTFMISDDIEPKAGRIIVFQLVDGKLQQVAEKEIKGVPFWLHEFHGKLLAAINTSIRLFEWTSTHELHMESSVFSSTLAIHTKTKGDFVLLGDLLRSFSLFAYSPLGGTFTQLAHDLESAWLSAMEIIDDDTFIGADTNFNLYLAQKDLNVADDPDRSKFLTQCGFFHLGDLVNVMKHGYLVMNYPHEMNNPIINKPILFGTYSGSIGLIAQIPKDYYEFLLKLQKNLASKIKSVGKIDYDFWRTYTNDKKTEPSLNFIDGDLIESFLDLNSTEMAECAEGIMYNMNGQNRTATVDDIIKIVEELRSSLINANH</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922L9G8</accession>
    <name>A0A922L9G8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aggresome assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DLGAP1</name>
        <name evidence="3" type="ORF">DERF_008694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000003">
        <property type="protein sequence ID" value="KAH9518097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922L9G8"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099572">
        <property type="term" value="C:postsynaptic specialization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005026">
        <property type="entry name" value="SAPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353">
        <property type="entry name" value="DISKS LARGE-ASSOCIATED PROTEIN DAP SAP90/PSD-95-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12353:SF31">
        <property type="entry name" value="LD44824P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03359">
        <property type="entry name" value="GKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9518097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="742" mass="85765" checksum="88E935F99B4C0486" modified="2023-02-22" version="1">MNQNDSINDQHHQQSDPALNDDNQIKINLNYNFVSYEDPNHLNELFGHNKGDGDDSKSLDEITFRYEHHRSETFAHFVQFPSSDSKEDSLNYSSSSVYDESDDDHHRKFRRQIYEEDFRVKIIPDVSPTTIVDDKQEEEVQQSKSRKLFPRQLSKCLSSTTNDLHSLFKKLSCLKRISSVVDLTHHKTTETLLKKKPRRLTYQNGKTLTKSDIIHCQQFDQIKESNDAKQQQSSENLEKSSSSSLIVPKLHIEEIAINGDIQIEQTDPVQETSSTRFDSQQTSTKIFDPDHKLDDHQTFIIYSSSEPANDLNNINTHHPEQYTISQSISLSNFHPVPKSKQSSESVDCVEHSSPSNYRSICLPSNHIHLPPAQSPATIINSESEYFSHSTDKNKKSKMIANQQNNHFESQNSQQNQPSYVNISRVNHGYVPYNRYTSEYRRDDSLLRSPVEDLESLYGESFADDWNKSRVKKGQSIEKSIHPNTTETSPTNQIKTTLASSKLFQKINSVDNSESSEDNKSNNNSFDKDWWLREHQPHSHKNHDGQAFMEKIQEQKARIQNKIQQGEKWLANTKDIPEECIGKIRSAIGKANLLLDKKFQQFQKLCEDSINQADGEQFKIQSDDLQGFWDMVMIQVHDVNQSFDELIQFKQNHWKPSPQLDQIDSNSKTMSPKIGSRQPSSNMTTIHNNTSSPRKYDNNNKITANINSPRNEERQRRLMEIKRRGKMTMKQDSDEIRIFAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LAN9</accession>
    <name>A0A922LAN9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">High mobility group</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HMGXB4</name>
        <name evidence="4" type="ORF">DERF_004947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Derf</strain>
            <tissue evidence="4">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000002">
        <property type="protein sequence ID" value="KAH9521275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LAN9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042477">
        <property type="entry name" value="HMGXB4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46584:SF1">
        <property type="entry name" value="HMG DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="308"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="308"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KAH9521275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="514" mass="57938" checksum="9B8DBAE8A5CF52F2" modified="2023-02-22" version="1">METTPAISRSGRVLKKSAKLLEMETETIGKSPRQSGPKPGKISIIGNDLNTTLSDDNIIKNVAPNNIRLKLNLSNHNQQLVQPSKITVVAEPIPITNNQAIITTTTTTPIQIRPNVMPAAKSSPTIGSLIFRVNNDSIKRPHENTVSTADVKRIKPNEPEEKTKSPIQHNIHIQSKDNQSPVVRIIANQQQSLPQQQQQQQQTLFKSTLSPISDKTTMNQDRLLNHKSFTTSTPKINTIIASRQILPRSIQEQRRINQANRARLQMQQQQQLKDELRQKQLDSANIKQQQTENHHNNNNNEETIKTVKKPAVSAYVLWCKENRSHIQSNYPELDFCNLSKKMGGIWHTLPKMEKDKWIRKAQLMTKYGIGFNMGAIYDYDDEDLKPEIVLGSLTLPITKTLDKTYGENFINTETSSIEGEKHYIGTELIDAQSYLSILGDSLMTISSYIQRGIKYNSEIRYCPMAAASTLLDTALVSMSTLASITLSLPNVSVNRKMAKKTIENATYFMPPSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LBY0</accession>
    <name>A0A922LBY0_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">DERF_003943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Derf</strain>
            <tissue evidence="6">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9530109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255">
        <property type="entry name" value="COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24255:SF31">
        <property type="entry name" value="CUBILIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5037962371" description="CUB domain-containing protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="142"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="325"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="464"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="608"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="805"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="947"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="1105"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="1258"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="1421"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="1946"/>
            <end position="2054"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="2075"/>
            <end position="2196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1062"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1536"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1610"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1823"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1917"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2208"/>
            <end position="2249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2332"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1614"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1917"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1927"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2229"/>
            <end position="2241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2332"/>
            <end position="2345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH9530109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="2360" mass="274513" checksum="67140223CB89664D" modified="2023-02-22" version="1">MAKLLTFTARFLVTFLYLQIEPGLCQQQQQIENHQHHHYSSNHQPISFNQQQHPSFILTENFNSLHSQQQTTPTQQITTLKPDDETIQYPKKDSFFNHPTTTESSSSLIIDTYNNNNDDKVGNVVADVPNTKTATTSSTNKCEFWLVSNEGNLTSFGDPSQSVNCVYRITPLNPTVCSVELHFNDFDVTDMRSEQKHKDAEQRQAVEKEFAQLSANRNSCVDNYLEFNNRKRYCHRDWNNRMDVVDIDPNYEKDFVFRLVLDRVVHSSGFNIKYKPLFDTCDKLTAKKLEKSKYENSNTNNNNNDHSIVDPVEMLASSLPSSSYCEKRHTEMEFEIKSANYPKNYSNNLDCVHYVIRKSENVCGLELKFIHFDIEESEGCAYDFFEIDGENFCGRLPNGSRNIFHFDTAVKSISFQTDSQVNGPGFHIKIRQINDCRNAFMPIETPAPASGNIRGGNQGRQQKCSILWHEREGKLSTLKYPDPYPNDLLCAYTIERNPHGHYCSIEMNFIDFDLQNTRDCSGDFFEIQNERYCGHSLRNERKIIPFNPDGYIRFLFKSDSTENGQGFLLNYTQIPCTKQMEDNVVMMNPAESLSKMMHDENSIHTEPCVKIYRDKKFDLISDTIDGHYKDNQNCHFTIKKYSDKVCYLEMHFKMFDLEASQDCQYDYMEIGSAVRLCGTLNQETSRIYVFDKPEMIINFHTDSTNERKGYRIHTEQLECQGDRIIREHYDHHHHHHHHEEPNEGLQSLEQYKFEQQQHYIQPTNDTQLLQQQENFVHQTSEFDPTIPEWKYLQNPSSSSSSSLLCSKTFRQKEFFIDSPNFPDNYPPDLDCLFMIVPYSLDVCKIEINFDSFELQPYDFEKNCLKSDFLDFDNKEQFCGKMTETQSRIYSFRRNETFFIHFHSDSFRTSFDKGFRLYVRQIECSSLLNQPNKLPVKQQKPQQQQNHCSRILMSSSFDIQSPLYPSPYPSNSYCDYRIVKFKAPGVNVCFLEVHFIEFDLQSSTDCNKDYVSFNGIKQCGSIAKDSVRLFPFYDNEFTISFFADPLVSGRGFFLKIRQNECPQTGHNDHGAKRIIKPPPSSSSSSSLIMKDDPFSPYQIYHANQICQQTFGSTYFEFESPNYPQYYLPSLSCVYTIQRRHSRFCKLELYFTDFDIEPSTKCTEDYLIIDNVKYCNTNRPESIMQIPFYEPEKRIYFRSVLFRPRKGFMIQARQIDCDTLILEPKNYDVKQNRQQLPISSSSADINSNKFIFLPSLPSICEICVTEVTGNIQSYDYPNFYPPNVNCTYRITPLPDNCMVQLRFVEFDFDYSPECNQDYLEINGIRYCGHQLKDVSMILMNKRKDDLTIRMVTSSRGAMVKPSFKGFRASYTQLPCLDTQTPSPSISNQIPHIQPATKSIAVENPQTLHPIPTPMIVHNEAIYCDQTFDDKMFEIKSPGYPYRYFDGLDCSYLIRKNSANVCRLKVTFTYFNVVGEDGNCRGDYLDIFSTRFCGILDRYTSKEIPFLQEKLLLHFHTNQQQTANGFHLALEQVDCIPGRPAMPHQKHSKTTTDEQKSITDYSGSKTNPKKLKSPNRKPIMTKNPFDYDDDEIISEFDTRNKATMEVEPHVIYEDSNKPNPTTFPTQQREEQQRKIPIRYYSRNITVINEDKPKIQPLSMMMMTTTSRPSQQRHLDDGHDYITVTTAPMTQQPQQQQQQKYDPPNTQKLCEQTFVDKIFFELKSTDLQMTRMNGGGAICHLHIRKAKTNVCQLDIMFMKYNLNDSSCGHQYLSVDGEKICGHIHETTTKRFWFQRPELYLFVNLMDIGPIDDDTFEIKVRQVECATNVDHGHHHPSSRPMQRPNENSDNHFPIKGQQQSIKSRFKQVSDIVQQIDEQQLYDNRHHHHYNDNNNNNNKPNEYKMQTYEMKQFRIPMIEQQHNHPMDADTNRPEQQQQKPYSSSETSYDPYCDLIENEMNFQIESPRDDSTITRCRYTIRKANDNVCAIDLKFQMFQLNEAMKCEREYLEIDSSRICGAFPVGHERRYHFMPNEYEKVIHFISSKSLNTRGDFRLDVKQIDTDCDKPTPTQKPTLTMPTVCDISVRNYRGHIKSPNYPAPYGDYTKCVYRIQAIGHEYCNVKLRIRDLDIELSSSDSHGGTVKCEKDWLQVDTQKLCGNKMDEQNEYTIPFEMHNGHKVAQIKFTSDAFGNGRGFDIEYKQELCVSEKMKTNLISPGQKGFRPPQIKLVKGDPYSSSPSSGGSSPSSMRPHYPPNYVSKAHMLKTMDRKEFIKMMLMAEQEQMKMKINQKGATEEPKINMLTTMSSLDNDDNMTMSSMITTTINSIPENMVIFTTTMSTNSEDSTENSSNSLITTEPSVTMDDVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCD4</accession>
    <name>A0A922LCD4_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_003106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCD4"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9529212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="86" mass="9496" checksum="FA5691EEED8944FC" modified="2023-02-22" version="1">MDKIEVGPTAISLQLPSKEYTKQPMNDVYNPYCGGKPAKLDNAKPCGTIVNATDMPEMISPFRSSIEYAGTQRSGGNKRYNLRLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LCL2</accession>
    <name>A0A922LCL2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">60S ribosomal protein L27, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MRPL27</name>
        <name evidence="3" type="ORF">DERF_003562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9529692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LCL2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9529692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="228" mass="26523" checksum="321E63B66E837A60" modified="2023-02-22" version="1">MASFLKIKNDLFSKCLRDINYFQSRSAKSPAMTQRGYKKKQRIFSLNKIPGDRVDERMMIGTQKHLKYFPGYNCGINPRDKSLYAITAGTVYYSIERVQLNSNNPLVQQYFVNTIQPYYNKYIHVIPDKLENEFRLCYLINIIMDKRKYTIMAAVTAAVFGAIGYYYYQKRDSIDEAIKKTADTIKQQADVVKQQTDNAQKNIQEAMKELEKNIPDKSQKATKLSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922LD62</accession>
    <name>A0A922LD62_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquinone biosynthesis monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">COQ6</name>
        <name evidence="2" type="ORF">DERF_001999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000001">
        <property type="protein sequence ID" value="KAH9528025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922LD62"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD-binding" evidence="1">
        <location>
            <begin position="117"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="1">
        <location>
            <begin position="394"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9528025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="502" mass="56355" checksum="A6C41EA98D6502A2" modified="2023-02-22" version="1">MFKKIFLSDIGFINSVSKSWPARQSKYCCSHPQHHRWLSNQAVNQENSIIQDDAYDIVINGGGIVGFSMFAAIKSSPFLSAKRVLLIEQQSPPQPSTSVMPEARKFSNRVSAITLSSKEFFEQLKIWDSLSPYAKSIQGMYVWSEHYQNENNRILQALHDLIQSNPNSLQHISYKTSVVDINQDVDVRDSQATTIKLKIVDMEDTQQQQKSIQTRLLIGCDGYKSIVRSKSTLPYFEADLNQMGIVGTLEVETLNNDNHIAFQRFVNDQLVIALLPLDKCHSSLVLSVPKQSLQEWMKLSDQEFISRLNNELIREPKIQSPLDKLASTFNIRQFNYDNAQIRSPATIRSIVTGSRAAFPLGFGTTIPFMVGTIQAKVPLLQALINKDKRVNTAIIGDAAHRVHPLAGQGLNLGLGDASTLFSCLDSKLSAGYELFASRSDSHEALSQALYDFERCRVLKLIPMMTAIHSMQTLFHFTPSVLLPIVNQMDMAKKLIVSFANSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HK63</accession>
    <name>A0A922HK63_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_016696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000010">
        <property type="protein sequence ID" value="KAH9490496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HK63"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9490496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="67" mass="7903" checksum="072D75ECED1BDB89" modified="2023-02-22" version="1">MNEKQMLHYDSRIDYDDDYSTEGTEDRLGGLEWDIFNKSAIYIDLYASKFPIAHQLLDEQKKLSITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKQ9</accession>
    <name>A0A922HKQ9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_015911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKQ9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9491180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="574" mass="65211" checksum="307F75409CD17A2E" modified="2023-02-22" version="1">MNNNIWLFRFSIIFLLYTIFLSSIHFDIINDDNHHHHHHQQQQQQQRSREYFLLPTAQAMKSDEILVAILAAKFLGLFHKDGDYKPKPPPPPPPPPPPPLFAPPIIIGGRKRCKPKKCCRNRLPKFLTESYTIDDGDDLDGYETDFDDNYDDGDDGGGGYEDIGVDINVSGGGGAAAAIGGYDESYGKNFGQPKYHQVPITDTNEYRSLEINNGNANHPHGMSGNNHGHNNNHGHNNNHGHNNNYGQPQQQKRQQIQVYASDDQQLSSPGNGEEYNTVMENGGGVSMVEEEIQPTFDDDPQLSLASKDIITTANDKKRKTFGGYLKSKFRGTKNTILGTNSNSDDTIKMGKSRINEINQKKKSKQPKLRQRKQKSKSRSRHRRRRRRQRQRKKSKSRRKPIEDDNEQKIIHLGEKPSSNLNDMEYGDGQQQQENSEIDEETETEMPTSDDQMNDEIDDAEQQQHMVIEKQKPPLQKEHNKQVQPQTFPLPVPMIRPMNMYPTMQRPPYPPNLVFPPMPPPLPPPPPPPLMMMRPPHSMIPHPSQPLIPPPPPPPPMILNPGQIVGEQHIVYPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKS9</accession>
    <name>A0A922HKS9_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_015012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HKS9"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="424" mass="49126" checksum="14247754953C4991" modified="2023-02-22" version="1">MYHQNPNYIRKYGGGGGPKHPQQQQQQQMNQEMAVGGGGGGMGGVVGGNVNRNYPYQKQMPYNPYYNPQQQQQQPTPPTQSVGKQIPPPSPQTPVVSPGQEMGANTDSSITVIQQQIDFINLRIDRLEQIVYQQQIMIMLQQQQQQNQQSEFPHKSQPSNPSNKSQPINTSSPSQETLPQHPQQHKQEETQQQQQQQQQQQQKQEETQQQQQQQAHPKQTTEKKENQAKLNQSLNHLCELFEKFFDQQLENPTESTQRKLVALPLVMPPGNENTNQNIIRQQQQQQQQQQQQQQQQQRIVAGNQNENINDNTDDENLDVKKLIKRNNSKDDRHRHKNDKSSSRLRLTAGNEQQQQQQQQHHLHQRRESLTKNVIEKVKRIPSDAPTALIAPTDYEHIYSIKNTNARYYEDEQHKLAHANKHIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HKU8</accession>
    <name>A0A922HKU8_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Echinoderm microtubule-associated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">DERF_013036</name>
        <name evidence="6" type="ORF">HUG17_6296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
            <tissue evidence="6">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="SDOV01000002">
        <property type="protein sequence ID" value="KAH7643934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="47802at2759"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000828236">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055439">
        <property type="entry name" value="Beta-prop_EML_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF55">
        <property type="entry name" value="ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE CG42247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23409">
        <property type="entry name" value="Beta-prop_EML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Doublecortin" evidence="5">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Doublecortin" evidence="5">
        <location>
            <begin position="193"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="950"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1283"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KAH7643934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9497019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="1329" mass="150733" checksum="989F4881267424E7" modified="2023-02-22" version="1">MNNHRLPIDFNIGPAPSSTISSKAIREASERKAKKLHFYQNGRPYGSKLTVSIIPGKEFTGLEQFYEFLTEKTRLLNGVHYIFTSNGKLIRSLDELEHDQTYVISCSKNFVHFAYGSSNPSQRLTTGTPTNAVRHKFAREDDLKLLRPLSSKFNNVYAVNHHYHKLNQNINNNCHIEKPQQTTIIHTPNRDIRTVTIVNNKNHDIHSKVILNLKTPKSFDLLLTDLGDAVQLKCPRVMFTSNGQMVNSISQLKHDLAHINLFYIDNEYPHEPLSMYPRSPTPKGYQSPIDNNCYHCNGFPMQQQLETLISHSLLNNNMNTNFSSSVQSNQVISPTINHDTLPFSPEVTNRRINRQTQATNQRKISTPKFDMSTPLFVDRSKQPEHQQCLGPIFGLDQITSDKYNQIQNYVEKLLNDTSIQIQNEGLLVSPSISPQQNLNVQQQQQQQQSKAERNRKNSMKLKKQQTERNSPKRTKSLPRGAMKLNPEPPIISRGPIKQADKKLSRISQIKRPNARIDTSKKKVGNLNKSSDDINYKTNSTFSENDLSFQCQHSKRSLPTLNRSTETINKQKQKQETLTPILKRKAIGSNESLKISQHKTPINNNFIQRQRKAKSPTPCLRLQVPDNNNEIFNTSTMTIRAGKSSENLFSNIKKQPFKLPVKSKSFVLSSSNNNQSSNSTKMKRGPSDLNVGAKAKSSIALNKLRDIEKHLHGTLSTSEYYLELDKVYGYNGKQVQNLVYLNTEELAFFSGVFAILWNHQSGKQRFYTEHEHDICCLRVDPSCEYIATGHDTNSTMMIRIWSIKTLKTVKILTNKCELIDMEFTTNNSLFMLTGGKESNISQWNWRLKINIANTTKSLDNNEQLYGLTVHPTETDIVVTYGKMHLVVWHFKKDRSIDSRTALQMQSKIIKTIHCAAFLQDNSLLTGDSQGNLTIWAPFEVDKVLEFAIKEVKGHESQLTCFKLTKENILISGDRDGAIKTWDVNDNEFRLLNAVKLPSISGSVSAITPPKKLDESMNIYIGTSNNFILKGSAIETEDYQIIFEGHYMAIRTCSLDYNNNIYTASLDRKICKWNDFGLVWKTDSSIQGMSSSVHPAGQVLAVGSATGIIAIFNSGSGEPIQYIQLTTVCIGCMSYDVNGDFLAAGCQDGCLHVIPVRDNGHTYDKVSILKGPSPILTLQWSIDTQFILTSVDDNMYQELILWDLPNTRYIRNVTSFSDNLQWHNVTCSGLEDARGTWDNEKFKDVINICKNYSPNLKCIVTGDENGFIRLFAYPCYDTKASYFQYKQGGGSVTDVKFAPNESFIASCNFNGTVFVWRLIEYPKLSKTMTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN11</accession>
    <name>A0A922HN11_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_013823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN11"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9497874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="442" mass="53389" checksum="7465A9BA1A438CAB" modified="2023-02-22" version="1">MLFYFRHFIYNAMKHIVDEYGTIEYRRLHYADLILYLYWLIRALFISLIYIDPERFPLYRYDYASLYFWDHRRILNKFFVIIVLLLIMGGLLCIKTFYFPKQDDDEFRFQVIYDCIVRNTDQYNKSRDTDENIAMKLSQRFENYQQQFARDHRLLSQITPIAKRMVSFKVWRDSWLEMDRVDKILFEKINKMKLFPYATFKGRSYIVLFILLADCVNYFLHLLYIVYQIFCYELVQNSLWMKITLMIETTIFIYNGFLLFQSAMLLACTIMSTYQAFHSGLSYLNQMFVSILDKSRHHNGKQITRKDVLNLGLIYRQHNKLSYYVLHDDKNTWSKSLYYYALISIPINITLMCELIVEDIPAQTEFVFIVIVVLHVITGVIPFMALAHVSNAFHKIRDHILPMQLKLKRNYLRTKLKYDDLYERLMHGKKIAFTFGYLERST</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN12</accession>
    <name>A0A922HN12_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glyco_18 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Cht11_3</name>
        <name evidence="7" type="ORF">DERF_013802</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">Derf</strain>
            <tissue evidence="7">Whole organism</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000007">
        <property type="protein sequence ID" value="KAH9497847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN12"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF390">
        <property type="entry name" value="CHITINASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036850211" evidence="5">
        <location>
            <begin position="19"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="32"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KAH9497847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="398" mass="46143" checksum="10768ED93C1FE4ED" modified="2023-02-22" version="1">MKLKILIFSLFFFIISSSSPSLSVQQQDQFKFKRVCYLRPEANFPIDRIIEQNLCTHIIIAFVSIGEQSELSYDQNVADFIRICRQSIDSNVMNSNVKLMFSIGAGGWKMASSTDTRRKHFVNSILQFIREYQLDGVDIDWEFPAWPKKLFQYFERNDFIDLLHEIRNGFNQMEHETGKHLILSAAVAAQFVIIQHSYRAKEMAKFVDFINLMTYDYFIYKWYFPYVGHNSPLHSPLLIPFDNGPAKTFTVKWSAEYWTKIGMPKHKIMVGIPTYGKRYILFHEAANFPGAIAIKGEDDMSYSEVCAFLKRNNTIMKYDGVANVPYAYNQREWISFENTESASKKAEWICMNNFGGIMIFSLNADDYRQQCSSSSSSIQLFPIHMAIRDTVINNYGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="3" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HN45</accession>
    <name>A0A922HN45_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">DERF_015981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Derf</strain>
            <tissue evidence="1">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000009">
        <property type="protein sequence ID" value="KAH9491249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HN45"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KAH9491249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="53" mass="5696" checksum="C3BB06EC95132CAF" modified="2023-02-22" version="1">MSASSSSSSSYLSNIIQNKKINYLNSNNYSGAVVDNETAGDNNDQDVYAFLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNE0</accession>
    <name>A0A922HNE0_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">DERF_014923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Derf</strain>
            <tissue evidence="2">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9494220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNE0"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KAH9494220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="100" mass="12258" checksum="CB7B2EC2DCA612D0" modified="2023-02-22" version="1">MIHKIIGKKNTLTPDDEKDYYHHHQDDHDDHDDDDECSKRFDYFGTMFQCNIENEKYYIGCLYYHHKLKNDDAIRIFDDHDFGRWAEFINKIKNTIRTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HNH2</accession>
    <name>A0A922HNH2_DERFA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">DERF_014133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Derf</strain>
            <tissue evidence="3">Whole organism</tissue>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HNH2"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KAH9493381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="295" mass="34495" checksum="3C2325A39FC30772" modified="2023-02-22" version="1">MLVRPKKRREYRNPNIHLIMINNHNDGKQFLIHNDYHSINDDDDHESQGHQYQMIMDTIFFDGNPLGFLCIKSNDMNDNSGMINLQQNPCKTWRQTGPLLRTIDQSITYSGQLYLISKQKQQVLFFDQELLKNISKEFPLSIKSLSDFIICKFRPNSNKQPDETMNATTILTEIETETETTTNKWRISTIIMIVFVFIVLCLWIVYHMMIVRRRRRRNKKRTNSKIAENSKKSISITDKNSENIMNKAIANKIIVQLTPMMKKYFTTTTSITTRSDSSSSNTTTLNKTSPIIKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HP04</accession>
    <name>A0A922HP04_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TSEN2</name>
        <name evidence="5" type="ORF">DERF_014394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Divergent Evolution of Astigmatic Mites and Household Pest Adaptations.</title>
            <authorList>
                <person name="Xiong Q."/>
                <person name="Wan A.T.-Y."/>
                <person name="Liu X.-Y."/>
                <person name="Fung C.S.-H."/>
                <person name="Xiao X."/>
                <person name="Malainual N."/>
                <person name="Hou J."/>
                <person name="Wang L."/>
                <person name="Wang M."/>
                <person name="Yang K."/>
                <person name="Cui Y."/>
                <person name="Leung E."/>
                <person name="Nong W."/>
                <person name="Shin S.-K."/>
                <person name="Au S."/>
                <person name="Jeong K.Y."/>
                <person name="Chew F.T."/>
                <person name="Hui J."/>
                <person name="Leung T.F."/>
                <person name="Tungtrongchitr A."/>
                <person name="Zhong N."/>
                <person name="Liu Z."/>
                <person name="Tsui S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Derf</strain>
            <tissue evidence="5">Whole organism</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="ASGP02000008">
        <property type="protein sequence ID" value="KAH9493655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A922HP04"/>
    <dbReference type="Proteomes" id="UP000790347">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="4">
        <location>
            <begin position="163"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KAH9493655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000790347"/>
        </source>
    </evidence>
    <sequence length="376" mass="43001" checksum="BD00075C08C1E320" modified="2023-02-22" version="1">MIAIGRLIEKEKLISIEHLPTILALNKMGFFGAHSSREIIFKSMIDSTTQNNRQQSQNKPKFTVGFFSLKTVDIPSALTTFIGDTNKLKKNENQNSTTTTKDQKTSFTSMKLNLEEAYFLSYVFGMLKIEKNPKEFYGLDELWQCCCRLSNDDSKSGGDCTKFVTRFAAYYYFRSQGFIVSNGFKFGVDYLLYEEGPPFNHSHYAVIVEYKYDDDDGDQKQNETCKYNEISGLIRISNNSRKELIQCTVIIPATYRSHLSDCGPGCIKYFHINLIHLQRQTLDTWQNNSGGGGEGSKNLLAVEMPTLLIVDWSVGRLFAQSDTNELRTPKQHWKIFLLFSQYFGFVCLLSSEPMSKKIEVHVQLGCTQQQQQLVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2023-02-22" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A922HQE5</accession>
    <name>A0A922HQE5_DERFA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">DERF_013538</name>
        <name evidence="10" type="ORF">HUG17_1090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dermatophagoides farinae</name>
        <name type="common">American house dust mite</name>
        <dbReference type="NCBI Taxonomy" id="6954"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Ecdysozoa</taxon>
            <taxon>Arthropoda</taxon>
            <taxon>Chelicerata</taxon>
            <taxon>Arachnida</taxon>
            <taxon>Acari</taxon>
            <taxon>Acariformes</taxon>
            <taxon>Sarcoptiformes</taxon>
            <taxon>Astigmata</taxon>
            <taxon>Psoroptidia</taxon>
            <taxon>Analgoidea</taxon>
            <taxon>Pyroglyphidae</taxon>
            <taxon>Dermatophagoidinae</taxon>
            <taxon>Dermatophagoides</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2013-05" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yim A.K.Y."/>
                <person name="Chan T.F."/>
                <person name="Ji K.M."/>
                <person name="Liu X.Y."/>
                <person name="Zhou J.W."/>
                <person name="Li R.Q."/>
                <person name="Yang K.Y."/>
                <person name="Li J."/>
                <person name="Li M."/>
                <person name="Law P.T.W."/>
                <person name="Wu Y.L."/>
                <person name="Cai Z.L."/>
                <person name="Qin H."/>
                <person name="Bao Y."/>
                <person name="Leung R.K.K."/>
                <person name="Ng P.K.S."/>
                <person name="Zou J."/>
                <person name="Zhong X.J."/>
                <person name="Ran P.X."/>
                <person name="Zhong N.S."/>
                <person name="Liu Z.G."/>
                <person name="Tsui S.K.W."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Derf</strain>
            <tissue evidence="11">Whole organism</tissue>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2020-06" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Ji K."/>
                <person name="Li J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
            <tissue evidence="10">Whole body</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="journal article" date="2021" name="World Allergy Organ. J." volume="14" first="0" last="0">
            <title>Chromosome-level assembly of Dermatophagoides farinae genome and transcriptome reveals two novel allergens Der f 37 and Der f 39.</title>
            <authorList>
                <person name="Chen J."/>
                <person name="Cai Z."/>
                <person name="Fan D."/>
                <person name="Hu J."/>
                <person name="Hou Y."/>
                <person name="He Y."/>
                <person name="Zhang Z."/>
                <person name="Zhao Z."/>
                <person name="Gao P."/>
                <person name="Hu W."/>
                <person name="Sun J."/>
                <person name="Li J."/>
                <person name="Ji K."/>
            </authorList>
            <dbReference type="PubMed" id="34659625"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">JKM2019</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="journal article" date="2022" name="Res Sq" volume="0" first="0" last="0">
            <title>Comparative Genomics Reveals Insights into the Diverg
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